Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coregulator activity

CASP8AP2 NCOA3 MED30 CCDC124 ARID3A NAB1 BRD7 MED12L TRIM21 MAML2 TRIM24

6.68e-065627411GO:0003712
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA3 MED30 CCDC124 BRD7 MED12L TRIM21 MAML2 TRIM24

1.62e-05303748GO:0003713
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C3 AKR1C1

8.09e-054742GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C3 AKR1C1

8.09e-054742GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C3 AKR1C1

8.09e-054742GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C3 AKR1C1

1.35e-045742GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C3 AKR1C1

1.35e-045742GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C3 AKR1C1

1.35e-045742GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C3 AKR1C1

1.35e-045742GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C3 AKR1C1

1.35e-045742GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C3 AKR1C1

1.35e-045742GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C3 AKR1C1

1.35e-045742GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C3 AKR1C1

2.01e-046742GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C3 AKR1C1

2.81e-047742GO:0072582
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

CASP8AP2 NCOA3 MED30 CCDC124 ARID3A RRAGA NAB1 BRD7 MED12L TRIM21 MAML2 PIH1D1 TRIM24

3.06e-0411607413GO:0030674
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C3 AKR1C1

3.74e-048742GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C3 AKR1C1

3.74e-048742GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C3 AKR1C1

3.74e-048742GO:0035671
GeneOntologyMolecularFunctionmolecular adaptor activity

CASP8AP2 NCOA3 MED30 CCDC124 ARID3A RRAGA NAB1 BRD7 MED12L TRIM21 MAML2 PIH1D1 TRIM24 PCM1

4.03e-0413567414GO:0060090
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C3 AKR1C1

4.80e-049742GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C3 AKR1C1

4.80e-049742GO:0070401
GeneOntologyMolecularFunctionGTPase activator activity

RASA1 ARHGAP31 VAV3 SIPA1 TBC1D8B SEC23A

5.90e-04279746GO:0005096
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C3 AKR1C1

5.98e-0410742GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C3 AKR1C1

5.98e-0410742GO:0032052
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1

7.29e-0411742GO:0030283
GeneOntologyMolecularFunctionmodification-dependent protein binding

UBQLN1 BRD7 TRIM24 RAD23A RAD23B

1.01e-03206745GO:0140030
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C3 AKR1C1

1.20e-0314742GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C3 AKR1C1

1.20e-0314742GO:0001758
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

UBQLN1 RAD23A RAD23B

1.37e-0359743GO:0031593
GeneOntologyMolecularFunctionsteroid binding

AKR1C3 SCP2 ATP1A1 AKR1C1

1.51e-03133744GO:0005496
GeneOntologyMolecularFunctionzinc ion binding

CA12 TRAF5 TRIM41 ZMYM2 TRIM21 SLFN11 AGBL2 TRIM24 SEC23A AGBL3

1.60e-038917410GO:0008270
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1

2.47e-0320742GO:0004303
GeneOntologyMolecularFunctionproteasome binding

RAD23A RAD23B

2.47e-0320742GO:0070628
GeneOntologyMolecularFunctioncholesterol transfer activity

SCP2 APOB

3.55e-0324742GO:0120020
GeneOntologyMolecularFunctionDNA damage sensor activity

XRCC3 RAD23B

3.55e-0324742GO:0140612
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C3 AKR1C1

3.55e-0324742GO:0004745
GeneOntologyMolecularFunctionsterol transfer activity

SCP2 APOB

3.85e-0325742GO:0120015
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C3 AKR1C1

4.16e-0326742GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C3 AKR1C1

4.16e-0326742GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C3 AKR1C1

4.48e-0327742GO:0008106
GeneOntologyMolecularFunctionprotein transmembrane transporter activity

SEC61A2 SEC61A1

4.81e-0328742GO:0008320
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1

5.51e-0330742GO:0018455
GeneOntologyMolecularFunctionlysine-acetylated histone binding

BRD7 TRIM24

5.51e-0330742GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

BRD7 TRIM24

5.88e-0331742GO:0140033
GeneOntologyMolecularFunctionmetallocarboxypeptidase activity

AGBL2 AGBL3

5.88e-0331742GO:0004181
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C3 AKR1C1

6.25e-0332742GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1

6.64e-0333742GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1

7.04e-0334742GO:0016628
GeneOntologyMolecularFunctionmacromolecule transmembrane transporter activity

SEC61A2 SEC61A1

7.04e-0334742GO:0022884
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA3 MED30

7.04e-0334742GO:0046966
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C3 SCP2 AKR1C1

7.36e-03107743GO:0033293
GeneOntologyMolecularFunctionubiquitin protein ligase binding

GPI TRAF5 RRAGA CUL7 PACRG

8.28e-03337745GO:0031625
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C3 ATP1A1 AKR1C1

2.30e-0516733GO:0032351
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

AKR1C3 SCP2 APOB ATP1A1 AKR1C1

3.71e-05106735GO:0050810
GeneOntologyBiologicalProcessparturition

NRK AKR1C3 AKR1C1

6.24e-0522733GO:0007567
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C3 SCP2 AKR1C1

6.24e-0522733GO:0042448
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C3 AKR1C1

7.38e-054732GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C3 AKR1C1

7.38e-054732GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C3 AKR1C1

7.38e-054732GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C3 AKR1C1

7.38e-054732GO:0008208
GeneOntologyBiologicalProcessregulation of steroid metabolic process

AKR1C3 SCP2 APOB ATP1A1 AKR1C1

1.17e-04135735GO:0019218
GeneOntologyBiologicalProcesssmall molecule catabolic process

GPI OTC ABAT AKR1C3 SCP2 PFKFB2 ECH1 AKR1C1

1.19e-04421738GO:0044282
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C3 AKR1C1

1.23e-045732GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C3 AKR1C1

1.23e-045732GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C3 AKR1C1

1.23e-045732GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C3 AKR1C1

1.23e-045732GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C3 AKR1C1

1.23e-045732GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C3 AKR1C1

1.23e-045732GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C3 AKR1C1

1.84e-046732GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C3 AKR1C1

1.84e-046732GO:0016095
GeneOntologyBiologicalProcessprotein side chain deglutamylation

AGBL2 AGBL3

1.84e-046732GO:0035610
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C3 AKR1C1

2.56e-047732GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C3 AKR1C1

2.56e-047732GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C3 AKR1C1

2.56e-047732GO:1900052
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C3 SCP2 AKR1C1

2.57e-0435733GO:0120255
GeneOntologyBiologicalProcessSRP-dependent cotranslational protein targeting to membrane, translocation

SEC61A2 SEC61A1

3.41e-048732GO:0006616
GeneOntologyBiologicalProcesspost-translational protein targeting to membrane, translocation

SEC61A2 SEC61A1

3.41e-048732GO:0031204
GeneOntologyBiologicalProcessprotein deglutamylation

AGBL2 AGBL3

3.41e-048732GO:0035608
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C3 AKR1C1

4.38e-049732GO:0044597
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C3 SCP2 AKR1C1

5.42e-0445733GO:0008207
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C3 AKR1C1

5.46e-0410732GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C3 AKR1C1

5.46e-0410732GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C3 AKR1C1

5.46e-0410732GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C3 AKR1C1

5.46e-0410732GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C3 AKR1C1

5.46e-0410732GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C3 AKR1C1

6.66e-0411732GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C3 AKR1C1

6.66e-0411732GO:0016115
GeneOntologyBiologicalProcesssteroid biosynthetic process

AKR1C3 SCP2 APOB ATP1A1 AKR1C1

8.75e-04209735GO:0006694
GeneOntologyCellularComponentGtr1-Gtr2 GTPase complex

RRAGA RRAGB

7.59e-054752GO:1990131
GeneOntologyCellularComponentSec61 translocon complex

SEC61A2 SEC61A1

1.26e-045752GO:0005784
GeneOntologyCellularComponenttranslocon complex

SEC61A2 SEC61A1

1.89e-046752GO:0071256
DomainSTI1

UBQLN1 RAD23A RAD23B

7.02e-0610743SM00727
DomainSTI1_HS-bd

UBQLN1 RAD23A RAD23B

7.02e-0610743IPR006636
DomainUBIQUITIN_1

UBQLN1 UBLCP1 RAD23A RAD23B

1.36e-0537744PS00299
DomainPlug_translocon

SEC61A2 SEC61A1

1.55e-052742PF10559
DomainSecY_su_dom

SEC61A2 SEC61A1

1.55e-052742IPR023201
DomainRad23

RAD23A RAD23B

1.55e-052742IPR004806
Domain-

RAD23A RAD23B

1.55e-0527421.10.10.540
DomainXPC-binding

RAD23A RAD23B

1.55e-052742PF09280
DomainSecY

SEC61A2 SEC61A1

1.55e-052742PF00344
DomainSECY_1

SEC61A2 SEC61A1

1.55e-052742PS00755
DomainSECY_2

SEC61A2 SEC61A1

1.55e-052742PS00756
Domain-

SEC61A2 SEC61A1

1.55e-0527421.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

1.55e-052742IPR019561
DomainSecY_CS

SEC61A2 SEC61A1

1.55e-052742IPR030659
DomainXPC-bd

RAD23A RAD23B

1.55e-052742IPR015360
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

1.55e-052742IPR002208
DomainUBQ

UBQLN1 UBLCP1 RAD23A RAD23B

2.49e-0543744SM00213
Domainubiquitin

UBQLN1 UBLCP1 RAD23A RAD23B

3.56e-0547744PF00240
DomainUBIQUITIN_2

UBQLN1 UBLCP1 RAD23A RAD23B

6.18e-0554744PS50053
DomainUbiquitin_dom

UBQLN1 UBLCP1 RAD23A RAD23B

8.19e-0558744IPR000626
DomainGtr1_RagA

RRAGA RRAGB

9.24e-054742PF04670
DomainGtr1_RagA

RRAGA RRAGB

9.24e-054742IPR006762
DomainUBA

UBQLN1 RAD23A RAD23B

2.24e-0430743SM00165
DomainUBA

UBQLN1 RAD23A RAD23B

3.88e-0436743PF00627
DomainALDOKETO_REDUCTASE_1

AKR1C3 AKR1C1

6.83e-0410742PS00798
DomainAldo/ket_reductase_CS

AKR1C3 AKR1C1

6.83e-0410742IPR018170
DomainAldo/keto_reductase

AKR1C3 AKR1C1

6.83e-0410742IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1C3 AKR1C1

6.83e-0410742PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C3 AKR1C1

6.83e-0410742PS00063
DomainUBA

UBQLN1 RAD23A RAD23B

7.04e-0444743IPR015940
DomainUBA

UBQLN1 RAD23A RAD23B

8.54e-0447743PS50030
Domain-

AKR1C3 AKR1C1

1.79e-03167423.20.20.100
DomainNADP_OxRdtase_dom

AKR1C3 AKR1C1

2.03e-0317742IPR023210
DomainAldo_ket_red

AKR1C3 AKR1C1

2.03e-0317742PF00248
DomainAldo/ket_red/Kv-b

AKR1C3 AKR1C1

2.03e-0317742IPR001395
DomainUBA-like

UBQLN1 RAD23A RAD23B

2.09e-0364743IPR009060
DomainBBOX

TRIM41 TRIM21 TRIM24

2.59e-0369743SM00336
Domain-

TRIM41 TRIM21 TRIM24

2.81e-03717434.10.45.10
Domainzf-B_box

TRIM41 TRIM21 TRIM24

2.93e-0372743PF00643
DomainPeptidase_M14

AGBL2 AGBL3

3.71e-0323742PF00246
DomainPeptidase_M14

AGBL2 AGBL3

3.71e-0323742IPR000834
DomainZF_BBOX

TRIM41 TRIM21 TRIM24

3.94e-0380743PS50119
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOA3 SATB2 UBQLN1 ARID3A PRRC2C NAB1 SCP2 ZMYM2 SLFN11 ATP1A1 TRIM24 KDM6A PCM1 RAD23A RAD23B

1.40e-081103761534189442
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

GPI CCDC124 PRRC2C NAT10 BRD7 GPATCH2 AKR1C3 APOB ATP1A1 ECH1 TBC1D8B AKR1C1 SDAD1 PCM1 SEC23A RAD23B

3.62e-081371761636244648
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA3 SATB2 ARID3A NAB1 BRD7 ZMYM2 ATP1A1 TRIM24 KDM6A

7.71e-0835176938297188
Pubmed

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.

SEC61A2 APOB SEC61A1

1.00e-0757639565615
Pubmed

Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.

UBQLN1 RAD23A RAD23B

1.00e-07576311827521
Pubmed

Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.

UBQLN1 RAD23A RAD23B

3.49e-07776320059542
Pubmed

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

UBQLN1 PRRC2C UBLCP1 RAD23A RAD23B

3.51e-076676524811749
Pubmed

Human transcription factor protein interaction networks.

NCOA3 SATB2 ARID3A PRRC2C NAT10 BRD7 ZMYM2 EIF3D CUL7 ATP1A1 ECH1 TRIM24 KDM6A SDAD1 PCM1

4.01e-071429761535140242
Pubmed

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.

UBQLN1 RAD23A RAD23B

5.57e-07876325752573
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GPI CRACD CCDC124 PRRC2C NAT10 ZMYM2 SLFN11 EIF3D ATP1A1 PIH1D1 ECH1 PCM1

8.40e-07934761233916271
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA3 ARID3A ZMYM2 TRIM24 KDM6A

1.11e-068376528794006
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

SATB2 AKR1C3 AKR1C1

1.19e-061076336313771
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

AKR1C3 SCP2 APOB AKR1C1

3.50e-064776411208732
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A2 SEC61A1

4.71e-06276218480044
Pubmed

Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins.

RAD23A RAD23B

4.71e-06276227771451
Pubmed

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

AKR1C3 AKR1C1

4.71e-06276216338060
Pubmed

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.

AKR1C3 AKR1C1

4.71e-06276223165153
Pubmed

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death.

AKR1C3 AKR1C1

4.71e-06276234830394
Pubmed

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.

AKR1C3 AKR1C1

4.71e-06276230367463
Pubmed

Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23.

RAD23A RAD23B

4.71e-0627627851894
Pubmed

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

RAD23A RAD23B

4.71e-06276225311859
Pubmed

ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3.

ARID3A AKR1C3

4.71e-06276235257428
Pubmed

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.

RRAGA RRAGB

4.71e-0627629394008
Pubmed

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.

RRAGA RRAGB

4.71e-0627627499430
Pubmed

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.

UBQLN1 UBLCP1 RAD23A RAD23B

6.13e-065476434761751
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOA3 CCDC124 PRRC2C NAT10 BRD7 ZMYM2 TRIM21 SIPA1 PCM1 SEC23A LRRC15

7.68e-06963761128671696
Pubmed

Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.

UBQLN1 RAD23A RAD23B

7.99e-061876316712842
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

SATB2 UBQLN1 ARID3A ZMYM2 TRIM24

8.33e-0612576532891193
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

GPI CASP8AP2 NCOA3 MED30 NAT10 AKR1C3 KDM6A UBLCP1 AKR1C1 RAD23A RAD23B

1.24e-051014761132416067
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C3 AKR1C1

1.41e-05376219320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C3 AKR1C1

1.41e-05376231780644
Pubmed

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.

RAD23A RAD23B

1.41e-05376210915768
Pubmed

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

RAD23A RAD23B

1.41e-05376226998601
Pubmed

Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

RRAGA RRAGB

1.41e-05376225567907
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C3 AKR1C1

1.41e-0537627626489
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C3 AKR1C1

1.41e-05376221232532
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C3 AKR1C1

1.41e-05376213678667
Pubmed

Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.

RAD23A RAD23B

1.41e-05376215336624
Pubmed

FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.

CASP8AP2 NCOA3

1.41e-05376215698540
Pubmed

Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line.

AKR1C3 AKR1C1

1.41e-05376223183084
Pubmed

Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

UBQLN1 RAD23A

1.41e-05376217098253
Pubmed

Cytoplasmic relocation of Daxx induced by Ro52 and FLASH.

CASP8AP2 TRIM21

1.41e-05376220697732
Pubmed

Histone H4K20 Demethylation by Two hHR23 Proteins.

RAD23A RAD23B

1.41e-05376232209475
Pubmed

3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.

RAD23A RAD23B

1.41e-05376210854423
Pubmed

Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23.

RAD23A RAD23B

1.41e-0537628808275
Pubmed

Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

RAD23A RAD23B

1.41e-0537628168482
Pubmed

Involvement of the DNA repair protein hHR23 in p53 degradation.

RAD23A RAD23B

1.41e-05376214645509
Pubmed

XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.

RAD23A RAD23B

1.41e-0537628692695
Pubmed

Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.

RAD23A RAD23B

1.41e-0537629371639
Pubmed

Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.

RAD23A RAD23B

1.41e-0537629372924
Pubmed

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.

RAD23A RAD23B

1.41e-05376222431748
Pubmed

NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23.

RAD23A RAD23B

1.41e-05376222575648
Pubmed

RagA, but not RagB, is essential for embryonic development and adult mice.

RRAGA RRAGB

1.41e-05376224768164
Pubmed

XPC interacts with both HHR23B and HHR23A in vivo.

RAD23A RAD23B

1.41e-0537629164480
Pubmed

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.

RRAGA RRAGB

1.41e-05376231649036
Pubmed

The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.

CCDC66 PCM1

1.41e-05376228235840
Pubmed

Rag GTPases are cardioprotective by regulating lysosomal function.

RRAGA RRAGB

1.41e-05376224980141
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

SEC61A2 TRAF5 UBQLN1 AKR1C3 ZMYM2 ZNF510 PFKFB2 ANKRD40 KDM6A

1.88e-0568676929987050
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

MED30 CCDC124 ARID3A PRRC2C EIF3D SIPA1 TBC1D8B SDAD1 PCM1

2.23e-0570176930196744
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

SATB2 ARID3A TRIM21 EIF3D PRORP TRIM24 RAD23B

2.62e-0539676726687479
Pubmed

Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.

UBQLN1 ECH1 RAD23A RAD23B

2.66e-057876429426014
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

NCOA3 SATB2 BRD7 SLFN11 TRIM24 KDM6A SEC23A

2.70e-0539876735016035
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

GPI PRRC2C NAT10 AKR1C3 ATP1A1 PCM1

2.75e-0526876633024031
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C3 AKR1C1

2.82e-05476220124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C3 AKR1C1

2.82e-05476210500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C3 AKR1C1

2.82e-05476216508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C3 AKR1C1

2.82e-05476219487289
Pubmed

Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.

XRCC3 RAD23B

2.82e-05476218708406
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1

2.82e-05476214967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C3 AKR1C1

2.82e-05476210393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C3 AKR1C1

2.82e-05476215193432
Pubmed

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.

BRD7 TRIM24

2.82e-05476219909775
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C3 AKR1C1

2.82e-05476231479646
Pubmed

Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.

RAD23A RAD23B

2.82e-05476210488153
Pubmed

Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins.

UBQLN1 RAD23A

2.82e-05476215004330
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1

2.82e-05476215222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C3 AKR1C1

2.82e-05476216191478
Pubmed

Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.

UBQLN1 RAD23A

2.82e-05476223823328
Pubmed

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.

RRAGA RRAGB

2.82e-05476233373332
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C3 AKR1C1

2.82e-05476215577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C3 AKR1C1

2.82e-05476210702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C3 AKR1C1

2.82e-05476217034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C3 AKR1C1

2.82e-05476217629694
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C3 AKR1C1

2.82e-05476229764944
Pubmed

Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

RAD23A RAD23B

2.82e-05476210373495
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C3 AKR1C1

2.82e-05476210526179
Pubmed

Genetic factors controlling structure and expression of apolipoproteins B and E in mice.

GPI APOB

2.82e-0547623034900
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C3 AKR1C1

2.82e-05476217888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C3 AKR1C1

2.82e-05476217442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C3 AKR1C1

2.82e-05476228329705
Pubmed

Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain.

NCOA3 TRIM24

2.82e-05476211851396
Pubmed

The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.

SEC61A2 SEC61A1

2.82e-05476210212142
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C3 AKR1C1

2.82e-05476216018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1

2.82e-05476217272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C3 AKR1C1

2.82e-05476219237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C3 AKR1C1

2.82e-05476218667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C3 AKR1C1

2.82e-05476228259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C3 AKR1C1

2.82e-05476221521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C1

2.82e-0547628274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C1

2.82e-05476216511129
InteractionSOX17 interactions

NCOA3 SATB2 ARID3A BRD7 ATP1A1 TRIM24 KDM6A

6.32e-0895757int:SOX17
InteractionLHX1 interactions

SATB2 ARID3A BRD7 TRIM24 KDM6A SDAD1

2.33e-06103756int:LHX1
InteractionCEBPA interactions

NCOA3 SATB2 UBQLN1 ARID3A PRRC2C AK5 NAB1 NAT10 SCP2 ZMYM2 SLFN11 ATP1A1 TRIM24 KDM6A PCM1 RAD23A RAD23B

2.43e-0612457517int:CEBPA
InteractionSOX7 interactions

NCOA3 SATB2 BRD7 TRIM24 KDM6A

1.36e-0582755int:SOX7
InteractionERG interactions

NCOA3 SATB2 ARID3A ZMYM2 TRIM21 TRIM24 KDM6A

1.94e-05223757int:ERG
InteractionFOXI1 interactions

NCOA3 SATB2 BRD7 TRIM24 KDM6A

2.38e-0592755int:FOXI1
InteractionRNF181 interactions

PIGN UBQLN1 PRRC2C TRIM24 UBLCP1 RAD23B

2.92e-05160756int:RNF181
InteractionLHX4 interactions

SATB2 UBQLN1 ARID3A BRD7 TRIM24 KDM6A

3.59e-05166756int:LHX4
InteractionDDX41 interactions

TRIM41 BRD7 TRIM21 SLFN11 PIH1D1 TRIM24

3.59e-05166756int:DDX41
InteractionDUXB interactions

SATB2 ZMYM2 TRIM24

3.88e-0518753int:DUXB
InteractionEGR2 interactions

NCOA3 ARID3A NAB1 BRD7 TRIM24 KDM6A

4.24e-05171756int:EGR2
InteractionPSMD11 interactions

UBQLN1 BRD7 SLFN11 CUL7 ATP1A1 UBLCP1 RAD23A RAD23B

4.97e-05353758int:PSMD11
InteractionAKR1C1 interactions

AKR1C3 TRIM21 AKR1C1

5.39e-0520753int:AKR1C1
InteractionRACK1 interactions

CCDC124 RASA1 PRRC2C BRD7 USP40 TRIM21 SLFN11 CUL7 PIH1D1 SEC61A1 SDAD1

5.59e-057047511int:RACK1
InteractionMED20 interactions

MED30 MED12L SCP2 ECH1 RAD23A RAD23B

5.82e-05181756int:MED20
InteractionPAX6 interactions

NCOA3 SATB2 ARID3A BRD7 ZMYM2 APOB TRIM24 KDM6A

6.41e-05366758int:PAX6
InteractionTBXT interactions

NCOA3 SATB2 ARID3A TRIM24 KDM6A

7.25e-05116755int:TBXT
InteractionHNF4A interactions

NCOA3 SATB2 ARID3A BRD7 ZMYM2 TRIM24 KDM6A

7.34e-05275757int:HNF4A
InteractionZFAND2B interactions

UBQLN1 PRRC2C UBLCP1 RAD23B

7.37e-0560754int:ZFAND2B
InteractionHNF1B interactions

NCOA3 SATB2 ARID3A BRD7 TRIM24 KDM6A

7.62e-05190756int:HNF1B
InteractionCFL1 interactions

ABAT ARHGAP31 NRK TRIM21 EIF3D CUL7 ATP1A1 PIH1D1

8.95e-05384758int:CFL1
InteractionCBX1 interactions

UBQLN1 ZMYM2 TRIM21 CUL7 ECH1 TRIM24 RAD23B

9.79e-05288757int:CBX1
InteractionGATA2 interactions

NCOA3 SATB2 ARID3A BRD7 TRIM24 KDM6A

9.83e-05199756int:GATA2
InteractionHERC2 interactions

MED30 ARID3A NAT10 SLFN11 EIF3D SIPA1 ECH1 PCM1 SEC23A

1.02e-04503759int:HERC2
InteractionSTK17A interactions

GPATCH2 EIF3D SDAD1

1.07e-0425753int:STK17A
InteractionFEV interactions

NCOA3 SATB2 ARID3A BRD7 TRIM24 KDM6A

1.10e-04203756int:FEV
InteractionUBL7 interactions

UBQLN1 TRIM21 RAD23A RAD23B

1.14e-0467754int:UBL7
InteractionTNFRSF11A interactions

TRAF5 TRIM21 VAV3

1.21e-0426753int:TNFRSF11A
InteractionPSPC1 interactions

CCDC124 PRRC2C BRD7 VAV3 SLFN11 EIF3D CUL7 SEC61A1 SDAD1

1.22e-04515759int:PSPC1
InteractionETV4 interactions

NCOA3 ECH1 TRIM24 KDM6A

1.27e-0469754int:ETV4
InteractionEIF5B interactions

GPI BRD7 SLFN11 CUL7 XRCC3 PIH1D1

1.39e-04212756int:EIF5B
InteractionTPI1 interactions

GPI ARID3A AKR1C3 TRIM21 CUL7 PIH1D1 TRIM24

1.45e-04307757int:TPI1
InteractionFOS interactions

NCOA3 ARID3A BRD7 TRIM21 TRIM24 KDM6A LRRC15

1.61e-04312757int:FOS
InteractionRAD23A interactions

TRAF5 UBQLN1 ECH1 ANKRD40 RAD23A RAD23B

1.87e-04224756int:RAD23A
InteractionNFIX interactions

SATB2 ARID3A BRD7 ATP1A1 TRIM24 KDM6A

2.01e-04227756int:NFIX
InteractionANXA5 interactions

GPI ABAT TRIM21 CUL7 TRIM24 LRRC15

2.01e-04227756int:ANXA5
InteractionKLF3 interactions

SATB2 ARID3A ZMYM2 ATP1A1 TRIM24 KDM6A

2.06e-04228756int:KLF3
InteractionFILIP1 interactions

SLFN11 PCM1 RAD23A

2.06e-0431753int:FILIP1
InteractionELF5 interactions

SATB2 BRD7 ZMYM2 TRIM24 KDM6A

2.21e-04147755int:ELF5
InteractionRAD23B interactions

ABAT UBQLN1 SLFN11 UBLCP1 RAD23A RAD23B

2.21e-04231756int:RAD23B
InteractionABAT interactions

GPI ABAT AKR1C3 RAD23B

2.26e-0480754int:ABAT
InteractionNAA40 interactions

GPI CRACD CCDC124 PRRC2C NAT10 ZMYM2 SLFN11 EIF3D ATP1A1 PIH1D1 ECH1 PCM1

2.47e-049787512int:NAA40
InteractionADCK2 interactions

GPI SEC61A2 ATP1A1 SEC61A1

2.60e-0483754int:ADCK2
InteractionCCDC40 interactions

TRAF5 PACRG PCM1

2.73e-0434753int:CCDC40
InteractionTBX4 interactions

NCOA3 SLFN11

2.84e-047752int:TBX4
InteractionPAX2 interactions

NCOA3 SATB2 BRD7 KDM6A

2.85e-0485754int:PAX2
InteractionIRF4 interactions

NCOA3 SATB2 BRD7 KDM6A

2.85e-0485754int:IRF4
InteractionPPIB interactions

UBQLN1 TRIM21 APOB CUL7 PIH1D1 TRIM24 PCM1

2.97e-04345757int:PPIB
InteractionGSC interactions

NCOA3 SATB2 KDM6A LRRC15

3.12e-0487754int:GSC
InteractionSRRM2 interactions

PRRC2C BRD7 SCP2 SLFN11 PFKFB2 CUL7 ATP1A1 PIH1D1

3.16e-04462758int:SRRM2
InteractionTXNL1 interactions

UBQLN1 PRRC2C PIH1D1 UBLCP1 RAD23A RAD23B

3.24e-04248756int:TXNL1
InteractionCMBL interactions

ABAT AKR1C3 PIH1D1 TRIM24

3.26e-0488754int:CMBL
InteractionCSK interactions

SEC61A2 TRAF5 UBQLN1 RASA1 AKR1C3 ZMYM2 ZNF510 PFKFB2 ATP1A1 ANKRD40 KDM6A

3.26e-048617511int:CSK
InteractionSEM1 interactions

UBQLN1 PRRC2C UBLCP1 RAD23A RAD23B

3.46e-04162755int:SEM1
InteractionAKR1C3 interactions

ABAT AKR1C3 AKR1C1

3.51e-0437753int:AKR1C3
InteractionEIF3A interactions

PRRC2C BRD7 SLFN11 EIF3D ATP1A1 XRCC3 PIH1D1

3.52e-04355757int:EIF3A
InteractionMYLK4 interactions

GPI ATP1A1 UBLCP1 RAD23B

3.55e-0490754int:MYLK4
InteractionCRX interactions

NCOA3 SATB2 ARID3A BRD7 TRIM24 KDM6A

3.68e-04254756int:CRX
InteractionAKR1C4 interactions

AKR1C3 AKR1C1

3.77e-048752int:AKR1C4
InteractionSLC12A1 interactions

USP40 ATP1A1

3.77e-048752int:SLC12A1
InteractionZBTB26 interactions

TRIM41 ZMYM2 RAD23A

3.80e-0438753int:ZBTB26
InteractionPSMA1 interactions

TRAF5 UBQLN1 ATP1A1 PIH1D1 ECH1 SEC23A RAD23A RAD23B

4.07e-04480758int:PSMA1
InteractionPSMC5 interactions

NCOA3 UBQLN1 TRIM21 CUL7 ATP1A1 UBLCP1 RAD23A RAD23B

4.30e-04484758int:PSMC5
InteractionSOX9 interactions

NCOA3 ARID3A BRD7 KDM6A

4.72e-0497754int:SOX9
InteractionTFF1 interactions

NCOA3 UBQLN1 XRCC3

4.77e-0441753int:TFF1
InteractionH3C1 interactions

ARID3A PRRC2C NAT10 BRD7 ZMYM2 SLFN11 TRIM24 DNAH8 KDM6A SDAD1 RAD23B

4.79e-049017511int:H3C1
InteractionCOL27A1 interactions

SLFN11 CUL7

4.84e-049752int:COL27A1
InteractionTLX1 interactions

NCOA3 SATB2 ARID3A BRD7 KDM6A

4.93e-04175755int:TLX1
InteractionISG15 interactions

GPI PRRC2C NAT10 AKR1C3 ATP1A1 PCM1 RAD23A RAD23B

4.93e-04494758int:ISG15
InteractionUBQLN4 interactions

UBQLN1 PRRC2C ZMYM2 UBLCP1 RAD23A RAD23B

5.28e-04272756int:UBQLN4
InteractionTRIM8 interactions

TRAF5 TRIM21 TRIM24 RAD23A

5.30e-04100754int:TRIM8
InteractionSEC61A2 interactions

SEC61A2 APOB SEC61A1

5.49e-0443753int:SEC61A2
InteractionH4C14 interactions

BRD7 TRIM21 CUL7 TRIM24

5.50e-04101754int:H4C14
InteractionPHGDH interactions

BRD7 TRIM21 CUL7 PIH1D1 KDM6A RAD23A RAD23B

5.72e-04385757int:PHGDH
InteractionCC2D2A interactions

ECH1 PCM1 TCTN2

5.88e-0444753int:CC2D2A
InteractionTRAF3 interactions

GPI TRAF5 VAV3 ECH1 TRIM24 RAD23A

5.93e-04278756int:TRAF3
InteractionAKR1D1 interactions

AKR1C3 AKR1C1

6.03e-0410752int:AKR1D1
InteractionLHX2 interactions

SATB2 ARID3A BRD7 TRIM24 KDM6A

6.03e-04183755int:LHX2
InteractionLHX3 interactions

SATB2 ARID3A BRD7 TRIM24 KDM6A

6.34e-04185755int:LHX3
InteractionXRCC5 interactions

NCOA3 BRD7 TRIM21 CUL7 ATP1A1 PIH1D1 TRIM24 RAD23A

6.48e-04515758int:XRCC5
InteractionDDX3X interactions

KIN PRRC2C BRD7 TRIM21 SLFN11 EIF3D CUL7 ATP1A1 PIH1D1

6.80e-04651759int:DDX3X
InteractionSOX2 interactions

GPI NCOA3 SATB2 ARID3A NAT10 BRD7 ZMYM2 SLFN11 CUL7 TRIM24 KDM6A SDAD1 SEC23A RAD23B

6.80e-0414227514int:SOX2
InteractionSUMO1 interactions

CASP8AP2 NCOA3 TRAF5 ZMYM2 CUL7 TRIM24

7.00e-04287756int:SUMO1
InteractionFOXA1 interactions

GPI NCOA3 SATB2 CCDC124 PRORP PIH1D1 KDM6A SDAD1

7.34e-04525758int:FOXA1
InteractionSEZ6L interactions

UBQLN1 TRIM24

7.35e-0411752int:SEZ6L
InteractionKLF15 interactions

NCOA3 ARID3A PRRC2C BRD7 TRIM24 KDM6A

7.39e-04290756int:KLF15
InteractionVCP interactions

UBQLN1 CCDC124 TRIM21 APOB SLFN11 CUL7 ATP1A1 PACRG PIH1D1 SEC61A1 AKR1C1 LRRC15 RAD23A RAD23B

7.44e-0414357514int:VCP
InteractionTLX3 interactions

NCOA3 SATB2 ARID3A BRD7 TRIM24 KDM6A

7.52e-04291756int:TLX3
InteractionPSMD14 interactions

UBQLN1 GPATCH2 ZMYM2 APOB PFKFB2 UBLCP1 RAD23A RAD23B

7.52e-04527758int:PSMD14
Cytoband10p15-p14

KIN AKR1C3 AKR1C1

8.69e-08676310p15-p14
GeneFamilyAldo-keto reductases

AKR1C3 AKR1C1

5.17e-0415412399
GeneFamilyEF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2

RAD23A RAD23B

7.50e-04184121269
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM41 TRIM21 TRIM24

1.30e-039541359
GeneFamilyCyclins|Mediator complex

MED30 MED12L

2.53e-03334121061
GeneFamilyRing finger proteins

TRAF5 TRIM41 TRIM21 TRIM24

3.41e-0327541458
GeneFamilySH2 domain containing

RASA1 VAV3

2.20e-02101412741
CoexpressionFLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DN

CA12 CASP8AP2 TRIM21 ANKRD40

1.93e-0631764M4866
CoexpressionRAF_UP.V1_DN

CA12 ABAT SATB2 GPATCH2 VAV3 KDM6A

2.10e-05193766M2726
CoexpressionGSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_HET_TCONV_UP

CA12 GPI SEC61A2 MED12L VAV3 SEC61A1

2.57e-05200766M5696
CoexpressionFLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP

CA12 NCOA3 ABAT RRAGA AKR1C3 SCP2 ZMYM2 AKR1C1 SEC23A

3.88e-05568769M4023
CoexpressionRB_P130_DN.V1_DN

RASA1 RRAGA NAB1 SEC23A MYORG

4.80e-05136765M2803
CoexpressionOLSSON_E2F3_TARGETS_UP

CA12 AKR1C3 AKR1C1

5.81e-0526763M18325
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

CA12 CASP8AP2 CRACD SATB2 MED30 CCDC66 KIN RASA1 NAT10 BRD7 ZMYM2 XRCC3 TRIM24 KDM6A PCM1

1.91e-0512527315facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_1000

PIGN RASA1 PRRC2C NAB1 GPATCH2 MED12L VAV3 PFKFB2

4.34e-05375738gudmap_developingKidney_e15.5_cortic collect duct_1000_k4
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500_K1

CA12 CASP8AP2 SATB2 MED30 CCDC66 KIN RASA1 NRK BRD7 ZMYM2 TRIM24 KDM6A UBLCP1 PCM1

7.26e-0512417314facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

CA12 CASP8AP2 CRACD MED30 CCDC66 KIN RASA1 NAT10 BRD7 ZMYM2 TRIM24 UBLCP1 PCM1 MYORG

8.33e-0512577314facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRRC2C VAV3 KDM6A PCM1 RYR2

1.28e-05176765749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 NRK VAV3 MAML2 ATP1A1

1.54e-051837652f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

NCOA3 ABAT ZMYM2 LRRC2 LRRC15

1.75e-0518876514bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 MED12L VAV3 MAML2 ATP1A1

1.75e-05188765bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 MED12L VAV3 MAML2 ATP1A1

1.80e-05189765977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 MED12L VAV3 MAML2 ATP1A1

1.85e-05190765e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CA12 SATB2 ARID3A APOB VAV3

1.99e-0519376532eb026d4317c1499d51294d396dfd5f293f9deb
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 MED12L VAV3 MAML2 ATP1A1

2.09e-05195765a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

RASA1 MED12L MAML2 PRORP RYR2

2.09e-051957656687e579582d7a239bee80846de0cf827a6f6a62
DrugBambuterol hydrochloride [81732-46-9]; Down 200; 10uM; PC3; HT_HG-U133A

SEC61A2 ZMYM2 ANKRD40 KDM6A RYR2 LRRC15 RAD23B

4.45e-061987675885_DN
DrugSulconazole nitrate [61318-91-0]; Down 200; 8.6uM; PC3; HT_HG-U133A

SEC61A2 NAB1 ZMYM2 RRAGB XRCC3 KDM6A RAD23B

4.60e-061997676652_DN
Drugalpha-methylcinnamic acid

AKR1C3 AKR1C1

1.10e-052762ctd:C510582
Drugcyclopentanone

AKR1C3 AKR1C1

3.29e-053762ctd:C007201
Drug4-benzoylbenzoic acid

AKR1C3 AKR1C1

3.29e-053762ctd:C058818
Drugcyclopentanol

AKR1C3 AKR1C1

3.29e-053762ctd:C016327
Drugdichloro(4-cymene)ruthenium(II)

AKR1C3 AKR1C1

3.29e-053762ctd:C530610
DrugAzathymine, 6 [932-53-6]; Down 200; 31.4uM; HL60; HT_HG-U133A

NAB1 ZMYM2 ZNF510 ANKRD40 KDM6A PCM1

4.33e-051917662466_DN
DrugIvermectin [70288-86-7]; Up 200; 4.6uM; HL60; HG-U133A

CA12 GPATCH2 SCP2 ZMYM2 SIPA1 ANKRD40

5.14e-051977661367_UP
Drugvinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A

CA12 PIGN AKR1C3 KDM6A PCM1 TCTN2

5.29e-051987667551_DN
DrugPregnanes

AKR1C3 AKR1C1

6.57e-054762ctd:D011278
Drugtetralol

AKR1C3 AKR1C1

6.57e-054762ctd:C019106
Druggliquidone

AKR1C3 AKR1C1

6.57e-054762ctd:C010969
Druggadobenate dimeglumine

CASP8AP2 KY

6.57e-054762CID006918204
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C3 AKR1C1

6.57e-054762ctd:C018156
Drugcloxazolam

AKR1C3 AKR1C1

6.57e-054762ctd:C005522
DrugDBD-H

AKR1C3 AKR1C1

6.57e-054762CID000131382
Drugglycidamide

CA12 TRAF5 USP40 AKR1C3 AKR1C1

7.50e-05130765ctd:C071834
DiseaseNeoplasms, Hormone-Dependent

AKR1C3 AKR1C1

1.91e-053752C0027661
DiseaseAmbiguous Genitalia

AKR1C3 AKR1C1

6.34e-055752C0266362
DiseasePseudohermaphroditism

AKR1C3 AKR1C1

6.34e-055752C0033804
DiseaseHermaphroditism

AKR1C3 AKR1C1

6.34e-055752C0019269
DiseaseIntersex Conditions

AKR1C3 AKR1C1

6.34e-055752C2930618
DiseaseSex Differentiation Disorders

AKR1C3 AKR1C1

6.34e-055752C2930619
DiseaseDisorders of Sex Development

AKR1C3 AKR1C1

1.33e-047752C0036875
Diseasealcohol use disorder (implicated_via_orthology)

RASA1 BRD7 ATP1A1 KDM6A RYR2

1.42e-04195755DOID:1574 (implicated_via_orthology)
DiseaseProstatic Cancer, Castration-Resistant

AKR1C3 TRIM24

2.27e-049752C3658266
DiseaseProstatic Neoplasms, Castration-Resistant

AKR1C3 TRIM24

2.27e-049752C3658267
DiseaseTachyarrhythmia

VAV3 RYR2

9.50e-0418752C0080203
DiseaseTachycardia

VAV3 RYR2

9.50e-0418752C0039231
Diseaseautoimmune disease

ARHGAP31 NAB1 VAV3 UBLCP1

1.00e-03173754EFO_0005140
Diseaseacute lymphoblastic leukemia, response to antineoplastic agent

NCOA3 MAML2

1.06e-0319752EFO_0000220, GO_0097327
Diseasemalignant astrocytoma (is_marker_for)

BRD7 ADGRB1

1.56e-0323752DOID:3069 (is_marker_for)
DiseasePigmented Basal Cell Carcinoma

RASA1 XRCC3

2.31e-0328752C1368275
DiseaseCarcinoma, Basal Cell

RASA1 XRCC3

2.48e-0329752C4721806

Protein segments in the cluster

PeptideGeneStartEntry
NNFPKNQTPVRMRRN

PFKFB2

451

O60825
NMQTTQIKQLFNPRT

AGBL3

841

Q8NEM8
NQLMRQLQRKDPSAF

BRD7

141

Q9NPI1
LQASKQFLQMRRQQP

ADGRB1

136

O14514
SNFNRRQLEMILNKP

AKR1C3

166

P42330
QQNQNVPLLSRKFMV

AADACL4

236

Q5VUY2
FNMQELVLKVRIQNP

ANKRD40

256

Q6AI12
NPNQVSERFQQLMKL

CASP8AP2

1961

Q9UKL3
PLEFLRDQPQFQNMR

RAD23A

231

P54725
LEFLRNQPQFQQMRQ

RAD23B

276

P54727
RQILPVLNIFKNMNG

PACRG

191

Q96M98
IQRFKICPTPNNQFM

RASA1

396

P20936
QRQLLLASENPQQFM

KIN

51

O60870
PRQPQVRQQQRLLQM

MED12L

2051

Q86YW9
TQRRLMNFKQNAAPL

AK5

271

Q9Y6K8
ERPLNLRMPNLQNRQ

NAB1

421

Q13506
LLKPPQSLRQFENNM

KY

326

Q8NBH2
PQPFLEMQQLRLARQ

LMAN1L

261

Q9HAT1
FKNMVPQQALVIRNG

ATP1A1

161

P05023
ALLKLIQQPQNASMF

ABAT

111

P80404
RANRNNLNPAQKLML

KDM6A

481

O15550
SPREMINNFRQVQKF

CA12

266

O43570
ENRKPFNFLPMQINT

PCM1

136

Q15154
MVRNFRCGQPLQNKV

OTC

21

P00480
LLQLQRQPQPFLALM

CUL7

656

Q14999
KLPQFAEIMNQISRN

DNAH8

3816

Q96JB1
QLNRPNKRNAMNKVF

ECH1

71

Q13011
QLFQAMRILDLPKNQ

LRRC2

141

Q9BYS8
MAALTRDPQFQKLQQ

GPI

1

P06744
INMAAVRRFQAQLPQ

LRRC29

191

Q8WV35
IFQLLRNMQLPNGVT

MED30

51

Q96HR3
FSPSLALNIIQNRNM

NAT10

786

Q9H0A0
ALNIIQNRNMGKPAQ

NAT10

791

Q9H0A0
GMNQLTQQRNPKQLL

MAML2

886

Q8IZL2
AQIPILRMNFKQELN

APOB

3431

P04114
NIKFGQRSPNAIPMN

CRACD

46

Q6ZU35
RRNMLQFNLQILPKS

EIF3D

111

O15371
LLNPNMVKNRDRQQA

CCDC66

896

A2RUB6
NSSFLPMKNENPRLN

AGBL2

801

Q5U5Z8
SQVRPMQQARAQLKL

KLHDC7B

386

Q96G42
NAQPILENNIGNRML

GPATCH2

461

Q9NW75
RSPPQEQINMLLNFK

RYR2

1966

Q92736
QENPNMRLSQLKQLL

CCDC124

186

Q96CT7
LQQLQGAARVFMPLQ

NRK

406

Q7Z2Y5
RPNLQLANMVQVIRQ

TRIM41

196

Q8WV44
RQNLPNLMNLIATVF

SEC61A2

236

Q9H9S3
KNRPFMGSISQQNIR

PIH1D1

166

Q9NWS0
MQLPQLNRLTLFGNS

LRRC15

266

Q8TF66
TPKQLRMQLQQRLQG

NCOA3

1166

Q9Y6Q9
LPPRFQRQQEQMKQQ

PRRC2C

671

Q9Y520
LLVNLRAMQNFLNLP

SATB2

411

Q9UPW6
MLPYTPNNQQQLLRK

SIPA1

411

Q96FS4
LQKEMQVIRSNPSFN

SLFN11

741

Q7Z7L1
MSNRNNNKLPSNLPQ

SDAD1

1

Q9NVU7
LAMKLQNLQLQPGNA

SCP2

531

P22307
NQQRLFSLKTMSPQN

PRORP

41

O15091
SNRFLQPVQKIDMNL

SEC23A

226

Q15436
QMVNQQQNKFDLRPL

TRAF5

331

O00463
SNFNRRQLEMILNKP

AKR1C1

166

Q04828
RALQQNFLAMAAQLP

ARID3A

476

Q99856
LQSRGQVMKRPNNIL

RPP38-DT

76

Q8N326
PMERQRNQLAGVKQQ

TEPP

81

Q6URK8
IKPNPLQMAFLAQQA

TRIM24

551

O15164
IKDLPRMNQSQFIQF

TBC1D8B

981

Q0IIM8
RQNLPNLMNLIATIF

SEC61A1

236

P61619
IPNVQQLEMNLRNFA

RRAGA

181

Q7L523
NPRAMQALLQIQQGL

UBQLN1

456

Q9UMX0
LIPNVQQLEMNLRNF

RRAGB

241

Q5VZM2
FQMEPSPRNQRKALN

ARHGAP31

471

Q2M1Z3
QSSLLRKQGLPLMNQ

PIGN

671

O95427
KNLRPNRQLANMVNN

TRIM21

61

P19474
LSKSPQNLNQRMDVF

ZMYM2

1311

Q9UBW7
RNFLMNPQNGLKIRP

UBLCP1

256

Q8WVY7
PLRFSTLFQEQQKMN

ZNF510

26

Q9Y2H8
FQRNDQQIFKMLPPE

USP40

421

Q9NVE5
LGKPVRALNINRMNN

TCTN2

441

Q96GX1
FPHKRLQQLMAQQPR

XRCC3

146

O43542
NLKEINLRPQMSQFL

VAV3

56

Q9UKW4
MLQNPQEKSQAYPRR

MYORG

1

Q6NSJ0