Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of female gonad development	WT1 ZFPM2	1.46e-05	3	46	2	GO:2000195
GeneOntologyBiologicalProcess	negative regulation of gonad development	WT1 ZFPM2	4.85e-05	5	46	2	GO:1905940
GeneOntologyBiologicalProcess	regulation of female gonad development	WT1 ZFPM2	1.73e-04	9	46	2	GO:2000194
GeneOntologyBiologicalProcess	positive regulation of male gonad development	WT1 ZFPM2	1.73e-04	9	46	2	GO:2000020
GeneOntologyBiologicalProcess	blood vessel development	ADGRB3 WT1 FOXO4 NCL PLG RAPGEF2 GATAD2A DYNC2H1 ZFPM2	1.80e-04	929	46	9	GO:0001568
GeneOntologyBiologicalProcess	vasculature development	ADGRB3 WT1 FOXO4 NCL PLG RAPGEF2 GATAD2A DYNC2H1 ZFPM2	2.46e-04	969	46	9	GO:0001944
GeneOntologyBiologicalProcess	diaphragm development	WT1 MYT1	3.17e-04	12	46	2	GO:0060539
GeneOntologyBiologicalProcess	positive regulation of gonad development	WT1 ZFPM2	3.17e-04	12	46	2	GO:1905941
GeneOntologyBiologicalProcess	regulation of male gonad development	WT1 ZFPM2	3.17e-04	12	46	2	GO:2000018
HumanPheno	Embryonal renal neoplasm	WT1 ZFPM2 SETBP1 BUB1	1.26e-05	49	16	4	HP:0011794
HumanPheno	Nephroblastoma	WT1 ZFPM2 SETBP1 BUB1	1.26e-05	49	16	4	HP:0002667
HumanPheno	Abnormal morphology of female internal genitalia	WT1 FIP1L1 SLC29A3 PLG RASA2 DYNC2H1 ZFPM2 SETBP1 BUB1	5.08e-05	665	16	9	HP:0000008
HumanPheno	Edema	WT1 SLC29A3 PLG PRPF8 RASA2 DYNC2H1 LYST INPPL1 BUB1	7.61e-05	699	16	9	HP:0000969
HumanPheno	Embryonal neoplasm	WT1 ZFPM2 SETBP1 BUB1	1.03e-04	83	16	4	HP:0002898
HumanPheno	Abnormality of the female genitalia	WT1 FIP1L1 SLC29A3 PLG RASA2 DYNC2H1 ZFPM2 SETBP1 BUB1	1.22e-04	741	16	9	HP:0010460
HumanPheno	Abnormal breast morphology	WT1 TNRC6B SLC29A3 RBM28 RASA2 ZFPM2 SETBP1	1.99e-04	441	16	7	HP:0031093
HumanPheno	Abnormality of fluid regulation	WT1 SLC29A3 PLG PRPF8 RASA2 DYNC2H1 LYST INPPL1 BUB1	2.01e-04	789	16	9	HP:0011032
HumanPheno	Abnormal internal genitalia	WT1 TNRC6B FIP1L1 SLC29A3 PLG PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	2.11e-04	1498	16	12	HP:0000812
HumanPheno	Streak ovary	WT1 ZFPM2 SETBP1	2.17e-04	39	16	3	HP:0010464
HumanPheno	Germ cell neoplasia	WT1 ZFPM2 SETBP1	2.17e-04	39	16	3	HP:0100728
HumanPheno	Abnormality of the breast	WT1 TNRC6B SLC29A3 RBM28 RASA2 ZFPM2 SETBP1	2.17e-04	447	16	7	HP:0000769
HumanPheno	Gynecomastia	WT1 SLC29A3 RBM28 ZFPM2	2.47e-04	104	16	4	HP:0000771
HumanPheno	Male breast abnormality	WT1 SLC29A3 RBM28 ZFPM2	2.47e-04	104	16	4	HP:0000770
HumanPheno	Aplasia/Hypoplasia of the diaphragm	WT1 ZFPM2	3.29e-04	9	16	2	HP:0010315
HumanPheno	Delayed puberty	WT1 SLC29A3 RBM28 RASA2 ZFPM2	3.57e-04	212	16	5	HP:0000823
HumanPheno	Kidney cancer	WT1 ZFPM2 SETBP1 BUB1	3.76e-04	116	16	4	HP:0005933
HumanPheno	Delayed skeletal maturation	WT1 SLC29A3 RBM28 RASA2 INPPL1 ZFPM2	4.61e-04	352	16	6	HP:0002750
HumanPheno	Ambiguous genitalia	WT1 DYNC2H1 ZFPM2 BUB1	4.85e-04	124	16	4	HP:0000062
HumanPheno	Testicular gonadoblastoma	WT1 ZFPM2	5.00e-04	11	16	2	HP:0000030
HumanPheno	Vanishing testis	WT1 ZFPM2	5.00e-04	11	16	2	HP:0012870
HumanPheno	Ovarian gonadoblastoma	WT1 ZFPM2	5.00e-04	11	16	2	HP:0000149
HumanPheno	Abnormal vagina morphology	WT1 DYNC2H1 ZFPM2 BUB1	5.48e-04	128	16	4	HP:0000142
HumanPheno	Abnormal testis morphology	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	5.86e-04	1129	16	10	HP:0000035
HumanPheno	Abnormality of the gingiva	FIP1L1 SLC29A3 PLG LYST SETBP1	5.98e-04	237	16	5	HP:0000168
HumanPheno	Non-obstructive azoospermia	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	5.99e-04	1132	16	10	HP:0011961
HumanPheno	Uterus didelphys	WT1 DYNC2H1	5.99e-04	12	16	2	HP:0003762
HumanPheno	Abnormal lung development	WT1 DYNC2H1 ZFPM2 SETBP1 BUB1	6.84e-04	244	16	5	HP:4000059
HumanPheno	Pulmonary hypoplasia	WT1 DYNC2H1 ZFPM2 SETBP1	6.89e-04	136	16	4	HP:0002089
HumanPheno	Azoospermia	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	7.22e-04	1157	16	10	HP:0000027
HumanPheno	Renal neoplasm	WT1 ZFPM2 SETBP1 BUB1	7.49e-04	139	16	4	HP:0009726
HumanPheno	Abnormality of the uterus	WT1 PLG DYNC2H1 SETBP1 BUB1	8.52e-04	256	16	5	HP:0000130
HumanPheno	Urinary tract neoplasm	WT1 ZFPM2 SETBP1 BUB1	8.55e-04	144	16	4	HP:0010786
HumanPheno	Hypergonadotropic hypogonadism	WT1 SLC29A3 ZFPM2	9.00e-04	63	16	3	HP:0000815
HumanPheno	Abnormal spermatogenesis	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	9.16e-04	1190	16	10	HP:0008669
HumanPheno	Lateral clavicle hook	DYNC2H1 INPPL1	9.48e-04	15	16	2	HP:0000895
HumanPheno	Abnormality of skeletal maturation	WT1 SLC29A3 RBM28 RASA2 INPPL1 ZFPM2	9.79e-04	405	16	6	HP:0000927
HumanPheno	Genital neoplasm	WT1 ZFPM2 SETBP1 BUB1	9.97e-04	150	16	4	HP:0010787
HumanPheno	Decreased serum testosterone concentration	WT1 RBM28 ZFPM2	1.08e-03	67	16	3	HP:0040171
HumanPheno	Hypoplasia of the vagina	WT1 ZFPM2	1.08e-03	16	16	2	HP:0008726
HumanPheno	Abnormality of the common coagulation pathway	FIP1L1 PLG LYST	1.13e-03	68	16	3	HP:0010990
HumanPheno	Hernia	WT1 TNRC6B SLC29A3 DYNC2H1 ZFPM2 SETBP1 BUB1	1.19e-03	589	16	7	HP:0100790
HumanPheno	Abnormal uterus morphology	WT1 DYNC2H1 SETBP1 BUB1	1.21e-03	158	16	4	HP:0031105
HumanPheno	Primary gonadal insufficiency	WT1 ZFPM2	1.22e-03	17	16	2	HP:0008193
HumanPheno	Female external genitalia in individual with 46,XY karyotype	WT1 ZFPM2	1.22e-03	17	16	2	HP:0008730
HumanPheno	Hypoplastic vertebral bodies	SLC29A3 INPPL1	1.22e-03	17	16	2	HP:0008479
HumanPheno	Decreased circulating androgen concentration	WT1 RBM28 ZFPM2	1.22e-03	70	16	3	HP:0030349
HumanPheno	Micropenis	WT1 SLC29A3 DYNC2H1 ZFPM2 SETBP1	1.24e-03	278	16	5	HP:0000054
HumanPheno	Aplasia/Hypoplasia of the lungs	WT1 DYNC2H1 ZFPM2 SETBP1	1.27e-03	160	16	4	HP:0006703
HumanPheno	Abnormality of the coagulation cascade	WT1 FIP1L1 PLG LYST	1.30e-03	161	16	4	HP:0003256
HumanPheno	Abnormal male internal genitalia morphology	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	1.32e-03	1243	16	10	HP:0000022
HumanPheno	Anterior bulging of the globe	SLC29A3 RASA2 INPPL1 ZFPM2 SETBP1	1.34e-03	283	16	5	HP:0000644
HumanPheno	Proptosis	SLC29A3 RASA2 INPPL1 ZFPM2 SETBP1	1.34e-03	283	16	5	HP:0000520
HumanPheno	Urogenital sinus anomaly	WT1 ZFPM2	1.37e-03	18	16	2	HP:0100779
HumanPheno	Gonadoblastoma	WT1 ZFPM2	1.37e-03	18	16	2	HP:0000150
HumanPheno	Abnormal lip morphology	WT1 TNRC6B SLC29A3 PLG RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	1.38e-03	1249	16	10	HP:0000159
HumanPheno	Short ribs	DYNC2H1 INPPL1 SETBP1	1.44e-03	74	16	3	HP:0000773
HumanPheno	Hypoplastic ribs	DYNC2H1 INPPL1 SETBP1	1.44e-03	74	16	3	HP:0000908
HumanPheno	Hypogonadism	WT1 SLC29A3 RBM28 PRPF8 RASA2 ZFPM2	1.50e-03	439	16	6	HP:0000135
HumanPheno	Functional abnormality of male internal genitalia	WT1 TNRC6B SLC29A3 PRPF8 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	1.57e-03	1269	16	10	HP:0000025
HumanPheno	Hypolipidemia	WT1 RBM28 ZFPM2	1.61e-03	77	16	3	HP:0045014
HumanPheno	Enlarged kidney	WT1 SLC29A3 DYNC2H1	1.68e-03	78	16	3	HP:0000105
HumanPheno	Abnormality of bone mineral density	WT1 SLC29A3 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	1.70e-03	822	16	8	HP:0004348
HumanPheno	Hypoplastic pubic bone	INPPL1 SETBP1	1.70e-03	20	16	2	HP:0003173
HumanPheno	Abnormal bone ossification	WT1 SLC29A3 RASA2 DYNC2H1 INPPL1 ZFPM2 SETBP1 BUB1	1.77e-03	827	16	8	HP:0011849
HumanPheno	Abnormal sex determination	WT1 ZFPM2	1.88e-03	21	16	2	HP:0012244
HumanPheno	Aplasia/Hypoplasia of the pubic bone	INPPL1 SETBP1	1.88e-03	21	16	2	HP:0009104
Domain	Ago_hook	TNRC6B TNRC6C	1.86e-05	3	47	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	1.86e-05	3	47	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	1.86e-05	3	47	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	1.86e-05	3	47	2	PF16608
Domain	Hr1	RTKN2 RHPN2	1.29e-04	7	47	2	SM00742
Domain	UBA-like	TNRC6B TNRC6C N4BP2	5.59e-04	64	47	3	IPR009060
Domain	HR1_rho-bd	RTKN2 RHPN2	1.79e-03	25	47	2	IPR011072
Domain	RRM	TNRC6B NCL TNRC6C RBM28	2.64e-03	230	47	4	PS50102
Domain	Kringle-like	PLG LY75	2.93e-03	32	47	2	IPR013806
Domain	-	TNRC6B NCL TNRC6C RBM28	3.26e-03	244	47	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	TNRC6B NCL TNRC6C RBM28	3.98e-03	258	47	4	IPR012677
Domain	Kinesin_motor_CS	KIF13B KIF2B	4.77e-03	41	47	2	IPR019821
Domain	Kinesin-like_fam	KIF13B KIF2B	5.24e-03	43	47	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF13B KIF2B	5.48e-03	44	47	2	PS00411
Domain	-	KIF13B KIF2B	5.48e-03	44	47	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF13B KIF2B	5.48e-03	44	47	2	IPR001752
Domain	Kinesin	KIF13B KIF2B	5.48e-03	44	47	2	PF00225
Domain	KINESIN_MOTOR_2	KIF13B KIF2B	5.48e-03	44	47	2	PS50067
Domain	KISc	KIF13B KIF2B	5.48e-03	44	47	2	SM00129
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6B TNRC6C	1.25e-04	7	35	2	M46421
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6B TNRC6C	2.13e-04	9	35	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6B TNRC6C	2.13e-04	9	35	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6B TNRC6C	2.66e-04	10	35	2	M48013
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION	WT1 ZFPM2	4.59e-04	13	35	2	M41725
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6B TNRC6C	4.59e-04	13	35	2	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	TNRC6B TNRC6C	7.96e-04	17	35	2	M27788
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP3K10 KIF13B FIP1L1 FOXO4 RAPGEF2 FGD6 LYST N4BP2 INPPL1	2.36e-06	861	48	9	36931259
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	WT1 DYNC2H1 ZFPM2	3.22e-06	21	48	3	24057671
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6B TNRC6C	5.59e-06	3	48	2	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6B TNRC6C	5.59e-06	3	48	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6B TNRC6C	5.59e-06	3	48	2	31670606
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6B TNRC6C	1.12e-05	4	48	2	21063388
Pubmed	HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.	HOXC6 HOXC10	1.12e-05	4	48	2	34763232
Pubmed	Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.	TNRC6B TNRC6C	1.86e-05	5	48	2	19838187
Pubmed	Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11.	HOXC6 HOXC10	2.79e-05	6	48	2	10391213
Pubmed	The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.	HOXC6 HOXC10	2.79e-05	6	48	2	9242489
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	FIP1L1 HOXC10 PRPF8	2.93e-05	43	48	3	26487511
Pubmed	A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.	HOXC6 HOXC10	3.90e-05	7	48	2	24651482
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6B TNRC6C	3.90e-05	7	48	2	19383768
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6B TNRC6C	3.90e-05	7	48	2	19470757
Pubmed	Hoxc gene collinear expression and epigenetic modifications established during embryogenesis are maintained until after birth.	HOXC6 HOXC10	6.67e-05	9	48	2	24155669
Pubmed	Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes.	HOXC6 HOXC10	6.67e-05	9	48	2	7959778
Pubmed	The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.	TNRC6B PRPF8	8.33e-05	10	48	2	36357400
Pubmed	Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.	WT1 ZFPM2	8.33e-05	10	48	2	19842175
Pubmed	The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.	WT1 ZFPM2	8.33e-05	10	48	2	17540364
Pubmed	Cognate homeo-box loci mapped on homologous human and mouse chromosomes.	HOXC6 HOXC10	1.02e-04	11	48	2	2878432
Pubmed	Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation.	WT1 ZFPM2	1.22e-04	12	48	2	19325248
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KIF13B DYNC2H1 N4BP2 INPPL1 BUB1 SORL1	1.53e-04	588	48	6	38580884
Pubmed	Organization and expression of mouse Hox3 cluster genes.	HOXC6 HOXC10	1.68e-04	14	48	2	8099712
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6B TNRC6C	1.68e-04	14	48	2	19716330
Pubmed	Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.	WT1 ZFPM2	1.68e-04	14	48	2	19301398
Pubmed	Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney.	WT1 HOXC10	1.68e-04	14	48	2	11493536
Pubmed	Transcription factor CHF1/Hey2 regulates coronary vascular maturation.	WT1 ZFPM2	1.68e-04	14	48	2	20619341
Pubmed	The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.	HOXC6 HOXC10	1.68e-04	14	48	2	16790475
Pubmed	Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.	WT1 ZFPM2	1.94e-04	15	48	2	12223418
Pubmed	Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.	WT1 ZFPM2	1.94e-04	15	48	2	23797856
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6B TNRC6C	1.94e-04	15	48	2	21981923
Pubmed	Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.	WT1 ZFPM2	1.94e-04	15	48	2	28195173
Pubmed	Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate.	HOXC6 HOXC10	2.21e-04	16	48	2	17520166
Pubmed	Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.	TNRC6B FCHO2	2.21e-04	16	48	2	32414810
Pubmed	A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.	HOXC6 HOXC10	2.21e-04	16	48	2	31747609
Pubmed	A census of human transcription factors: function, expression and evolution.	WT1 FOXO4 HOXC6 HOXC10 MYT1 ZFPM2 SETBP1	2.34e-04	908	48	7	19274049
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	FIP1L1 RAPGEF2 PRPF8 INPPL1	2.44e-04	220	48	4	24550385
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	FIP1L1 PLG GATAD2A FGD6 INPPL1 ARHGAP44 SORL1	2.47e-04	916	48	7	32203420
Pubmed	Hox patterning of the vertebrate rib cage.	HOXC6 HOXC10	2.50e-04	17	48	2	17626057
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ADGRB3 TNRC6B TNRC6C SETBP1	2.65e-04	225	48	4	12168954
Pubmed	Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.	WT1 HOXC10	3.14e-04	19	48	2	21858105
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ADGRB3 KIF13B TNRC6B NCL RAPGEF2 N4BP2 ARHGAP44	3.34e-04	963	48	7	28671696
Pubmed	Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.	WT1 ZFPM2	3.49e-04	20	48	2	21385577
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	TNRC6B TNRC6C	4.23e-04	22	48	2	22187428
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	WT1 ZFPM2	4.23e-04	22	48	2	25079229
Pubmed	Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.	WT1 ZFPM2	4.23e-04	22	48	2	23987514
Pubmed	WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.	WT1 ZFPM2	4.23e-04	22	48	2	23095882
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	TNRC6B PRPF8	4.63e-04	23	48	2	20696395
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6B TNRC6C	4.63e-04	23	48	2	28811219
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	ADGRB3 TNRC6B PLG FCHO2 RAPGEF2	4.91e-04	475	48	5	31040226
Pubmed	FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.	WT1 ZFPM2	5.05e-04	24	48	2	10892744
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	NCL RBM28 PRPF8	5.06e-04	112	48	3	28416769
Pubmed	A human MAP kinase interactome.	MAP3K10 RTKN2 NCL RAPGEF2 N4BP2	5.45e-04	486	48	5	20936779
Pubmed	Characterization of Staufen 1 ribonucleoprotein complexes.	NCL KIF2B	5.48e-04	25	48	2	15303970
Pubmed	The transcription factor GATA4 is required for follicular development and normal ovarian function.	WT1 ZFPM2	5.93e-04	26	48	2	23769843
Pubmed	Fine mapping of human HOX gene clusters.	HOXC6 HOXC10	5.93e-04	26	48	2	8646877
Pubmed	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.	HOXC6 HOXC10	6.40e-04	27	48	2	20417598
Pubmed	The human HOX gene family.	HOXC6 HOXC10	7.39e-04	29	48	2	2574852
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	FIP1L1 NCL PRPF8	7.80e-04	130	48	3	35545047
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	GLYATL1 TNRC6B HOXC6 TNRC6C	8.53e-04	307	48	4	37499664
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	NCL PRPF8	9.01e-04	32	48	2	15848144
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXC6 HOXC10	9.01e-04	32	48	2	37167859
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TNRC6B TNRC6C RAPGEF2 RASA2 ERV3-1 MYT1 ARHGAP44 SETBP1	9.07e-04	1489	48	8	28611215
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FIP1L1 NCL RBM28 PRPF8 N4BP2	9.57e-04	551	48	5	34728620
Pubmed	Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.	WT1 ZFPM2	1.14e-03	36	48	2	19411759
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	TNRC6B FSD1L NCL TNRC6C	1.19e-03	336	48	4	31253590
Pubmed	Epicardial-myocardial signaling directing coronary vasculogenesis.	WT1 ZFPM2	1.20e-03	37	48	2	20299672
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF13B KIF2B	1.20e-03	37	48	2	11416179
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	FIP1L1 NCL GATAD2A PRPF8	1.23e-03	339	48	4	30415952
Pubmed	Identification of 10 murine homeobox genes.	HOXC6 HOXC10	1.27e-03	38	48	2	1683707
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXC6 HOXC10	1.27e-03	38	48	2	15042701
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	RTKN2 SLC29A3	1.27e-03	38	48	2	23273568
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXC6 HOXC10	1.27e-03	38	48	2	11857506
Pubmed	PRC1 sustains the integrity of neural fate in the absence of PRC2 function.	HOXC6 HOXC10	1.27e-03	38	48	2	34994686
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXC6 HOXC10	1.34e-03	39	48	2	33257809
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	NCL TNRC6C RBM28 PRPF8	1.34e-03	347	48	4	16033648
Cytoband	12q13.3	HOXC6 HOXC10	1.32e-03	51	48	2	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3q23	RASA2 NMNAT3	2.01e-03	63	48	2	chr3q23
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B TNRC6C	1.12e-03	25	36	2	775
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF13B KIF2B	3.78e-03	46	36	2	622
GeneFamily	HOXL subclass homeoboxes	HOXC6 HOXC10	4.80e-03	52	36	2	518
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RTKN2 RASA2 FGD6	7.89e-03	206	36	3	682
CoexpressionAtlas	kidney_P3_CapMes_Crym_top-relative-expression-ranked_1000	WT1 SLC29A3 HOXC6 HOXC10 LY75 FGD6 DYNC2H1 LYST SETBP1 BUB1	5.45e-06	749	48	10	gudmap_kidney_P3_CapMes_Crym_1000
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B FCHO2 LY75 RASA2 LYST	1.15e-06	172	48	5	d354424c1f861b6607dfd63b9724f4c237b30275
Disease	platelet reactivity measurement, thrombus formation measurement	N4BP2 SETBP1	5.19e-05	7	47	2	EFO_0004985, EFO_0007615
Disease	Gonadal Dysgenesis, 46,XY	WT1 ZFPM2	6.91e-05	8	47	2	C0018054
Disease	diastolic blood pressure, systolic blood pressure	TNRC6B FIP1L1 RTKN2 GATAD2A DYNC2H1 N4BP2 SETBP1	8.62e-05	670	47	7	EFO_0006335, EFO_0006336
Disease	plasminogen activator inhibitor 1 measurement	PLG ZFPM2 SNX8	8.87e-05	54	47	3	EFO_0004792
Disease	46,XY partial gonadal dysgenesis	WT1 ZFPM2	1.35e-04	11	47	2	C4510744
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	WT1 ZFPM2	1.62e-04	12	47	2	DOID:3827 (implicated_via_orthology)
Disease	breast carcinoma	TNRC6B RTKN2 PLG GATAD2A RASA2 MYT1 ZFPM2 SETBP1	1.87e-04	1019	47	8	EFO_0000305
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	TNRC6B ZFPM2	3.74e-04	18	47	2	EFO_1000649, HP_0000131
Disease	Alzheimer disease, gastroesophageal reflux disease	ADGRB3 GATAD2A RHPN2 SORL1	4.77e-04	228	47	4	EFO_0003948, MONDO_0004975
Disease	Congenital diaphragmatic hernia	WT1 ZFPM2	5.12e-04	21	47	2	C0235833
Disease	TEMPS-A questionnaire	ADGRB3 DYNC2H1	7.28e-04	25	47	2	EFO_0004783
Disease	Myeloid Leukemia, Chronic	WT1 SETBP1	9.81e-04	29	47	2	C0023473
Disease	angina pectoris	PLG FGD6 DYNC2H1	1.05e-03	125	47	3	EFO_0003913
Disease	Tinnitus	TNRC6B FIP1L1 RTKN2	1.18e-03	130	47	3	HP_0000360
Disease	factor VIII measurement, venous thromboembolism	FCHO2 ZFPM2	1.35e-03	34	47	2	EFO_0004286, EFO_0004630
Disease	bone quantitative ultrasound measurement	RHPN2 SETBP1	1.77e-03	39	47	2	EFO_0004514
Disease	Diaphragmatic Hernia	WT1 ZFPM2	1.96e-03	41	47	2	C0019284
Disease	venous thromboembolism, von Willebrand factor measurement	FCHO2 ZFPM2	2.05e-03	42	47	2	EFO_0004286, EFO_0004629

Protein segments in the cluster

Peptide	Gene	Start	Entry
TLGKTLWRGKSNNSE	ERV3-1	371	Q14264
SGAWGVNKIISSLSS	BUB1	511	O43683
KTNESLGTWSTQGCK	ADGRB3	826	O60242
WKLSSISEKSENGGS	FCHO2	736	Q0JRZ9
SGSTDTWNGKTLKIP	ARRDC4	261	Q8NCT1
KAGSTSWTGFQTKAE	RBM28	641	Q9NW13
ISKTIQTLGSWGSLS	RASA2	541	Q15283
QTLGSWGSLSKSKSS	RASA2	546	Q15283
TVSAGKGSATSNWKK	GATAD2A	571	Q86YP4
SNWKKTPLSTGGTLA	GATAD2A	581	Q86YP4
LKGLGEGSKQWSSSA	MAP3K10	576	Q02779
TLGKFDQLGKTNTSW	FSD1L	406	Q9BXM9
SKGGQLWCTTTKAIS	ZFPM2	176	Q8WW38
KGDSNSSAGWKNSIR	FOXO4	141	P98177
TSTASRKANSSVGKW	FIP1L1	281	Q6UN15
LNASSKSKLGSWAET	GLYATL1	141	Q969I3
TAISNASDVWKKGGS	LY75	131	O60449
GKNSTWSGESKTLVL	NCL	476	P19338
WKKESNLTSTLSGGG	HOXC6	196	P09630
KNSKAGSGGKSQITW	DYNC2H1	651	Q8NCM8
TLTKTCSKSQGSWGN	GIMAP2	56	Q9UG22
SIGSSKASGSKQQWT	LYST	2716	Q99698
ENTTGNWLTAKSGRK	HOXC10	256	Q9NYD6
SSQPALASKSQSKWG	DNAJC9-AS1	76	A6NH13
GKDTTISGKGSSQWL	KIF2B	606	Q8N4N8
TWLLKDSLGGNSKTA	KIF13B	311	Q9NQT8
WTLASKRGGNSAQKA	PWWP3A	211	Q2TAK8
GWKTNTRITDSGSKT	RUSC1	276	Q9BVN2
VKDNWGKTSVSQTSS	RTKN2	526	Q8IZC4
GPSKKTSVSNAGQWL	FAM47E	186	Q6ZV65
ESLNKGSGSLWTTKF	SLC29A3	331	Q9BZD2
IGNWSDSKSITTIKG	SORL1	1731	Q92673
KSDSDKISNGSSINW	TNRC6C	1371	Q9HCJ0
LNSSTWGSLKQALKG	SNX8	276	Q9Y5X2
NVTSWFTSKGLGKTL	INPPL1	441	O15357
FQSKASNSWTGKGQA	ST6GALNAC2	51	Q9UJ37
SKTKNGITCQKWSST	PLG	116	P00747
WQQTSKSSGLSSSLQ	ARHGAP44	156	Q17R89
LSWGTNKNRQKSAST	RHPN2	641	Q8IUC4
SGSTTFTKIVNKWNT	PRPF8	1251	Q6P2Q9
KKWRSLGSLSQGSTN	RAPGEF2	926	Q9Y4G8
ASSAAVWKKSQGAGS	ZNF414	281	Q96IQ9
KFWSKSSQLGDTTTG	FGD6	646	Q6ZV73
TLKGVAAGSSSSVKW	WT1	246	P19544
KKGSAGNTWSQLSNN	SETBP1	266	Q9Y6X0
SWKGASVQKSTGSKN	TNRC6B	456	Q9UPQ9
RKTELKSSTWTGSQN	ZNF114	191	Q8NC26
WGTSSQKLKTLGSSN	N4BP2	931	Q86UW6
EGSLNGSSFSWKSLK	MYT1	926	Q01538
GSTWKGKSTQSTEGK	NMNAT3	236	Q96T66