WNK1 WNK3

WNK1 WNK3

SPANXN1 SPANXB1

SPANXN1 SPANXB1

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 PCDH15 PCDHGC3

FAT2 CELSR3 NCAN MUC4

NCOR2 RERE

Functional proteomics mapping of a human signaling pathway.

TOM1L2 RLF NCOR2 ZNF106 FLNC ERCC6 AP1G1 PDE4DIP RNF216 SMAD5

Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.

WNK1 WNK3

RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.

GTF2H1 ERCC6

Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.

PLIN4 SENP7

A human MAP kinase interactome.

TOM1L2 ZNF106 FLNC NAP1L5 SIMC1 NFYA WNK1 CCDC88B

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

BPTF NCOR2 FLNC SALL1 MYO9B SF3A1 NFYA ZBTB10 SPEN PRPF39

Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.

NCOR2 SPEN

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients.

MUC4 SMAD5

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TSPOAP1 PDE4DIP OGFOD1 RERE MAPKBP1 SPEN SENP7

Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.

NCOR2 SPEN

Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.

WNK1 WNK3

Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor.

NCOR2 SPEN

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.

WNK1 WNK3

SLC26A9 is a Cl(-) channel regulated by the WNK kinases.

WNK1 WNK3

Human hypertension caused by mutations in WNK kinases.

WNK1 WNK3

Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.

NCOR2 SPEN

WNK kinases sense molecular crowding and rescue cell volume via phase separation.

WNK1 WNK3

Isolation of novel heart-specific genes using the BodyMap database.

PDE4DIP PATJ

Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

EVL FLNC

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

WNK1 WNK3

Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.

NEO1 ROBO3

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.

AP1G1 NCAN

Chromosomal location of three unconventional myosin heavy chain genes in the mouse.

MYO9B NCAN

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.

NCOR2 SPEN

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

CDCA2 KIAA1210 NCOR2 SPEN

Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.

NCOR2 RERE

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

WNK1 WNK3

The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.

NCOR2 SPEN

Interaction network of human early embryonic transcription factors.

RLF BPTF NCOR2 SALL1 RERE SPEN

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

BPTF NCOR2 ERCC6 RAD17

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

WNK1 WNK3

KLHL2 interacts with and ubiquitinates WNK kinases.

WNK1 WNK3

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.

GTF2H1 ERCC6

Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.

MYO9B NCAN

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.

WNK1 WNK3

The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.

SPANXN1 SPANXB1

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

FAT2 CELSR3

TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

NFYA CCNA1

Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis.

SPANXN1 SPANXB1

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

ZNF106 WDR75 AP1G1 SIMC1 RNF216

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

NCOR2 SPEN

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

WNK1 WNK3

Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.

MYO9B NCAN

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

USHBP1 RCHY1 PDE4DIP RERE MAPKBP1 WNK1 SPEN

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

RLF CDCA2 BPTF ERCC6 ZBTB10 SPEN SENP7

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOR2 SALL1 TSPOAP1 PATJ WNK1 SPEN

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.

NEO1 SMAD5

Alternative splice variants encoding unstable protein domains exist in the human brain.

FAT2 MAPKBP1

A genome-wide association study of optic disc parameters.

SALL1 RERE

Phenotypic analysis of mice completely lacking netrin 1.

NEO1 ROBO3

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

FAT2 CELSR3 PCDHGC3

An atlas of combinatorial transcriptional regulation in mouse and man.

NCOR2 GTF2H1 NFYA ZNF200 ZNF407 RERE SPEN SMAD5

A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.

NCOR2 SF3A1

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.

NEO1 ROBO3

Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.

GTF2H1 ERCC6

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RLF CDCA2 NCOR2 FLNC GTF2H1 ERCC6 WDR75 AP1G1 MYO9B ZBTB10

KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).

GTF2H1 ERCC6

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

FAT2 CELSR3 PCDHGC3

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

BPTF NCOR2 SPEN

Human transcription factor protein interaction networks.

RLF CDCA2 BPTF NCOR2 SALL1 NFYA ZBTB10 RERE SPEN SMAD5

Prorenin receptor is critical for nephron progenitors.

SALL1 SMAD5

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CDCA2 BPTF NCOR2 SALL1 SF3A1 SIMC1 SPEN C1orf174

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

NEO1 SF3A1 NCAN WNK1

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.

SALL1 RERE

SR protein kinases promote splicing of nonconsensus introns.

RLF CELSR3 NSUN5P2 SPEN CCDC88B

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

ARHGAP24 MAN2C1 RNF216 CCDC88B CES2 SENP7 RAD17

Transcriptome analysis of mouse stem cells and early embryos.

BPTF ZNF106 PDE4DIP WNK1 SENP7

Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.

SALL1 SMAD5

MYC multimers shield stalled replication forks from RNA polymerase.

CDCA2 BPTF NCOR2 ZNF106 FLNC GTF2H1 WDR75 SF3A1

E-cadherin is required for intestinal morphogenesis in the mouse.

CHGA MUC4

Large-scale characterization of HeLa cell nuclear phosphoproteins.

EVL BPTF NCOR2 ZNF106 SF3A1 RERE SPEN

Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.

ROBO3 SMAD5

Widespread and dynamic translational control of red blood cell development.

MAN2C1 CDKL3 WNK3

Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.

SALL1 SMAD5

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

BPTF NCOR2

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

BPTF NCOR2 SALL1 PCDH15 SPEN

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NCOR2 SALL1 MYO9B PATJ WNK1 SPEN

Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.

SALL1 SMAD5

Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.

GPC6 SMAD5

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

USHBP1 TSPOAP1 RCHY1 PDE4DIP SYCE1

N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.

CHGA SMAD5

The transcription factor gene Nfib is essential for both lung maturation and brain development.

NEO1 ROBO3

Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.

NEO1 SMAD5

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

NCOR2 SPEN

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RLF NCOR2 SALL1 ZBTB10 RERE

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

NCOR2 ZNF106 ZBTB10

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.

GTF2H1 ERCC6

ARHGAP24 NAP1L5

CDKL3 PCDHGC3 SMAD5

ZNF106 MAPKBP1

FAT2 PCDH15

RLF ZNF106 SALL1 ZNF296 ZBTB10 ZNF200 ZNF407

NCOR2 RERE

NEO1 TSPOAP1 ROBO3

WNK1 WNK3

NEO1 ARHGAP24 USHBP1 CDKL3 GPC6 SENP7

CDCA2 PLIN4 BPTF MYO9B ZNF407 RERE MAPKBP1 PATJ GPC6 WNK1

SALL1 GPC6

NCOR2 SMIM29 NCAN MAPKBP1 CES2

USHBP1

391

nan

16

CCDC88B

556

CDKL3

476

DOP1A

1131

GCSAM

61

BPTF

1246

ERCC6

16

RAD17

656

TSPOAP1

1776

AP1G1

806

ERCC6

16

OGFOD1

396

MUC4

4841

NCOR2

586

FAT2

1126

EVL

121

CES2

396

FLNC

211

NSUN5P2

181

GPR152

346

PCDHGC3

126

PRPF39

41

PCDH15

496

ARHGAP24

1

GPC6

436

CCNA1

31

CCNA1

36

CORO6

251

MAN2C1

216

MAPKBP1

961

CDCA2

671

KIAA1210

896

CELSR3

1056

C1orf174

181

SALL1

91

NFYA

326

NR1D2

271

PLIN4

1151

SENP7

816

SLC6A19

351

TEDC2

181

FER1L5

876

NAP1L5

1

NCAN

506

NEO1

1191

SMIM29

1

SIMC1

351

RNF216

256

RERE

726

SPANXN1

16

SF3A1

341

SMAD5

236

CHGA

156

GTF2H1

321

SPEN

2836

RLF

1811

WDR75

586

PATJ

1321

SYCE1

286

ROBO3

351

nan

91

TAS1R2

241

ZNF200

186

SPANXB1

21

RCHY1

201

ZBTB10

591

ZNF407

2041

WNK1

2226

UGGT2

116

XKR5

491

TOM1L2

171

ZNF106

1201

ZNF296

291

WNK3

1041

MYO9B

1211

PDE4DIP

691