Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

DNHD1 ATRX NAV3 PFKFB2 RFC3 NLRP8 TDRD12

6.04e-037465573.40.50.300
Domain-

PIK3CG PLA2G4B PRF1

9.47e-031485532.60.40.150
DomainAAA

NAV3 RFC3

1.03e-0252552PF00004
DomainATPase_AAA_core

NAV3 RFC3

1.10e-0254552IPR003959
Pubmed

Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.

FCRL1 FCRL3

7.36e-06355233597097
Pubmed

ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.

ATRX CENPC

1.47e-05455215242786
Pubmed

Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.

RFC3 CDC34

1.47e-05455232640224
Pubmed

Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.

FCRL1 FCRL3

2.45e-05555218704934
Pubmed

Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.

FCRL1 FCRL3

2.45e-05555216849395
Pubmed

IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.

FCRL1 FCRL3

2.45e-05555211929751
Pubmed

Identification of a family of Fc receptor homologs with preferential B cell expression.

FCRL1 FCRL3

2.45e-05555211493702
Pubmed

Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome.

APOF DGKA

5.13e-0575528661157
Pubmed

Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse.

APOF DGKA

6.83e-0585529808778
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

JCAD TBKBP1 NIPSNAP1 PFKFB2 RASSF4 ARID1A

7.33e-0544655624255178
Pubmed

The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.

FCRL1 FCRL3

1.60e-041255217273841
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

CCNT2 ATRX CENPC TIMM50 RFC3 ARID1A

1.93e-0453355630554943
Pubmed

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.

PLAA CDC34

2.21e-041455221070969
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

PLAA TIMM50 RFC3 NHP2 CDC34 TBC1D24

2.80e-0457155637167062
Pubmed

Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.

ATRX NHP2

2.90e-041655225416818
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

JCAD PLAA ACO2 NIPSNAP1 CAMSAP3 TIMM50 NAV3 TBC1D24

4.01e-04113955836417873
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ERCC4 RPAP1 ATRX NEMF CAMSAP3 DGKA

5.55e-0465055638777146
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PLAA CENPC ACO2 NIPSNAP1 TIMM50 RFC3 ARID1A NHP2

1.23e-03135355829467282
Pubmed

A COFRADIC protocol to study protein ubiquitination.

TIMM50 PFKFB2 RFC3

1.27e-0313455324816145
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SAAL1 ERCC4 PLAA ATRX DGKA ALS2 HMGXB3

1.54e-03108455711544199
Cytoband1q21-q22

FCRL1 FCRL3

3.51e-04235521q21-q22
ToppCelltumor_Lung-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

SLC9A2 FCRL1 PRF1 WFDC1

3.19e-051465548b2d104fdb0fdb09410450c6c651e1edb00cae44
ToppCellVE-CD8-memory_CD4|VE / Condition, Cell_class and T cell subcluster

GREB1L PRF1 CAMSAP3 ALS2

3.73e-051525549401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCellHealthy-B_cell|Healthy / disease group, cell group and cell class

JCAD FCRL1 CAMSAP3 APOF

3.83e-051535547f82cd61b3f1ebaee3e4bbf68ba858a67c2065e7
ToppCellCOVID-19_Severe-B_cell|COVID-19_Severe / disease group, cell group and cell class

FCRL1 FCRL3 PRF1 NLRP8

3.83e-05153554701a7d92ee7b22277c8462742a530347cc6f061a
ToppCellVE-Treg-naive_CD4|VE / Condition, Cell_class and T cell subcluster

FCRL3 CENPC NIPSNAP1 DGKA

4.13e-051565546501baf73616e702946de9fb13d267e30a68888b
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3|TCGA-Stomach / Sample_Type by Project: Shred V9

FCRL1 FCRL3 PIK3CG NAV3

5.39e-05167554d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBKBP1 CENPC HMGXB3 TBC1D24

5.51e-05168554b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCellfacs-Heart-LV-3m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOXD1 FCRL1 PRF1 DENND1C

5.77e-051705542491f3849e34b0ccd06015fa59d15e3d7963c76d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FCRL1 FCRL3 PIK3CG DENND1C

6.18e-0517355462ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCellASK428-Immune-B_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

FCRL1 FCRL3 ZNF805 SNX13

6.32e-05174554b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FCRL1 FCRL3 DGKA DENND1C

6.32e-051745541b2a2129c08bac01fc638692313b196759a1e0d7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FCRL1 FCRL3 DGKA DENND1C

6.32e-051745545bde24eb588dc588efc413811379548120ec0c7f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L MOXD1 DGKA GLP2R

6.75e-0517755496d639407f79669f3990138793d157b94273581c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MOXD1 DGKA GLP2R SORCS1

7.05e-051795549ba8693fba2175bca9ff9735cc04e657abeb9084
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

MOXD1 FCRL1 FCRL3 RFC3

7.05e-051795545be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MOXD1 NAV3 GLP2R SORCS1

7.52e-051825543dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

MOXD1 HMCN2 NAV3 GLP2R

8.01e-05185554fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FCRL1 PIK3CG PRF1 DENND1C

8.35e-051875549d298f43ae81d72091b31aaa6df41046d4aa31c5
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

JCAD CFAP221 CYP39A1 SORCS1

8.35e-051875547e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GREB1L MOXD1 HMCN2 NAV3

8.52e-05188554ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GREB1L MOXD1 HMCN2 NAV3

8.88e-05190554efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_natural_killer_[NK]_(1)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FCRL3 PIK3CG PRF1 DENND1C

9.43e-051935541a22bfc704d8d6d108215f17f03bdf56f46bf8cf
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FCRL3 PIK3CG PRF1 DENND1C

9.62e-05194554b88cb13c4819e6462bb306d2302b737d3848711f
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_lymphoid_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FCRL3 PIK3CG PRF1 DENND1C

9.62e-0519455469f7bedf6f0be338e4317c22125e727fb82000fc
ToppCellPCW_13-14-Immune_Lymphocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FCRL3 PIK3CG PRF1 DENND1C

9.62e-0519455436678999d0c1c5b0aab206fec7a8c36a0f43c56a
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FCRL1 FCRL3 PIK3CG PRF1

9.82e-051955544570644bcf8bbdfcd70f3cd8840eb94d3df383c8
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MOXD1 HMCN2 NAV3 GLP2R

9.82e-05195554ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FCRL1 FCRL3 PIK3CG APOF

1.04e-04198554863765ccc0205dc28864dae85af339c283194c96
ToppCell(2)_B_cell-(24)_B_cell_cycling|(2)_B_cell / shred on Cell_type and subtype

ATRX WFDC1 RFC3 OR2B6

1.06e-04199554d5a9a8a71c4de8cbcef947943f60838731bc640b
ComputationalGenes in the cancer module 18.

MOXD1 CASP2 PFKFB2 RFC3 ARID1A NHP2 CDC34

9.34e-05451277MODULE_18
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

DNHD1 NAV3 CASP2 ARID1A

1.58e-04148544C0279702
Diseasecitrulline measurement

HMCN2 GLP2R

6.12e-0420542EFO_0009777
Diseaseplatelet crit

LMAN1L JCAD SLC9A2 ATRX NAV3 ARID1A NHP2

1.68e-03952547EFO_0007985
DiseasePapillary Renal Cell Carcinoma

DNHD1 NAV3 CASP2

1.68e-03128543C1306837
DiseaseRenal Cell Carcinoma

DNHD1 NAV3 CASP2

1.68e-03128543C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

DNHD1 NAV3 CASP2

1.68e-03128543C1266043
DiseaseChromophobe Renal Cell Carcinoma

DNHD1 NAV3 CASP2

1.68e-03128543C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

DNHD1 NAV3 CASP2

1.68e-03128543C1266044

Protein segments in the cluster

PeptideGeneStartEntry
LVPDPGCHYDQLIEI

ACO2

326

Q99798
GADELPYLRCPLHTI

PFKFB2

406

O60825
LHPLEPLLDTKCDAY

CCNT2

111

O60583
YLIKACDTPLHPLGR

ALS2

1371

Q96Q42
PVELLLCYLLLHPVD

APOF

21

Q13790
YGLAHCRGLPTDLLL

DNHD1

3336

Q96M86
VLIPTLPPHLLDYCC

DENND1C

246

Q8IV53
LPRGCPLSLEDLLYV

CAMSAP3

281

Q9P1Y5
CEYPLISRILHGPCE

RASSF4

236

Q9H2L5
YPESICLPVLDGLLH

ARID1A

2076

O14497
YCAELIEHPLNISLG

GGT3P

256

A6NGU5
LAYPSCPELHILSFL

OR10W1

6

Q8NGF6
PYVIDHFLCEVPALL

OR2B6

171

P58173
LPYGPALIEHCLLEN

NEMF

191

O60524
GVHRHEEYLPCLLLP

NLRP8

181

Q86W28
HYELLVLTPPVILGD

HMCN2

2841

Q8NDA2
LARYIHCPKPEGDAL

LRRC75A

116

Q8NAA5
FCLLLLLLDPHSPET

LMAN1L

11

Q9HAT1
AYVPRHELCLSDPGL

JCAD

321

Q9P266
LALCPELAPYATILA

HMGXB3

1191

Q12766
PGLVDYTLEPLHVLL

PRF1

336

P14222
RSHNLEVPELLPCGY

NAV3

1991

Q8IVL0
CGLLRDHILPPSSIY

DGKA

321

P23743
PSEPHLCLLDVGYLI

PLA2G4B

606

P0C869
LPLQYICAPDSEHTL

GREB1L

1766

Q9C091
IDGARYHALLIPSCP

GATD1

81

Q8NB37
YICHPEPLLDLVTAC

ATRX

266

P46100
EGLYLHTLLEPTVLP

GLP2R

281

O95838
FGDLLCTLHETPYIL

CENPC

896

Q03188
ELHCEALRGSPPILY

FCRL1

226

Q96LA6
KIFTLPGDCLIYPAH

ETHE1

181

O95571
ELHCESLRGSPPILY

FCRL3

401

Q96P31
DCSLLDPLPKQSYLH

CYP39A1

436

Q9NYL5
LLHCLYDSDPPTLLE

SAAL1

141

Q96ER3
LAGDTLPIEVYCHLP

NHP2

81

Q9NX24
QHVLPPLSCDYDLSL

CASP2

126

P42575
GRLYELLTHCIPPEI

RFC3

276

P40938
CKGDDTLLVPIHAYP

CFAP221

141

Q4G0U5
PKLHLDEDYPCSLVG

NIPSNAP1

96

Q9BPW8
DLCEVLLYLLLPPGD

SNX13

226

Q9Y5W8
HCESNPLLYLLPVLT

TDRD12

461

Q587J7
LHLGFLCEYDALPGI

PM20D2

106

Q8IYS1
ISILLDNYCHPIALP

PIK3CG

516

P48736
CPALPAVVALLLHYS

TBC1D24

131

Q9ULP9
AEPLLCPSGYECHIL

WFDC1

151

Q9HC57
PPYTLVLELTGVLLH

TIMM50

146

Q3ZCQ8
IYETGDVCISILHPP

CDC34

86

P49427
LSLGTPLDPHYVLLE

MOXD1

291

Q6UVY6
YHKLPTIVPESCLLI

SLC9A2

101

Q9UBY0
VCIIPSSDIYPHGLI

PLAA

71

Q9Y263
LPGSEYLTHELLLSC

RPAP1

991

Q9BWH6
LTIIHPLLGCSDPYA

ERCC4

551

Q92889
LRGDPVHCLLPYCSL

SORCS1

511

Q8WY21
PPCTDLDLHYLALRG

TBKBP1

191

A7MCY6
SLGCPVPRPELIYHL

ZNF805

51

Q5CZA5