Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	4.52e-05	14	102	3	GO:0015386
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	6.90e-05	16	102	3	GO:0015385
GeneOntologyMolecularFunction	DNA ligase (ATP) activity	LIG3 LIG4	7.73e-05	3	102	2	GO:0003910
GeneOntologyMolecularFunction	DNA ligase activity	LIG3 LIG4	7.73e-05	3	102	2	GO:0003909
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9A9 SLC9A7 SLC9A6	1.18e-04	19	102	3	GO:0022821
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	3.46e-04	27	102	3	GO:0051139
GeneOntologyMolecularFunction	ligase activity, forming phosphoric ester bonds	LIG3 LIG4	5.34e-04	7	102	2	GO:0016886
GeneOntologyBiologicalProcess	medial motor column neuron differentiation	LHX4 LHX3	2.42e-05	2	102	2	GO:0021526
Domain	FERM-adjacent	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	3.17e-11	13	99	6	IPR014847
Domain	FA	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	3.17e-11	13	99	6	SM01195
Domain	FA	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	3.17e-11	13	99	6	PF08736
Domain	Ez/rad/moesin-like	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	9.68e-10	21	99	6	IPR000798
Domain	FERM_CS	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.37e-09	24	99	6	IPR019747
Domain	FERM_C	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	4.02e-09	26	99	6	PF09380
Domain	FERM_C	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	5.15e-09	27	99	6	SM01196
Domain	FERM_PH-like_C	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	5.15e-09	27	99	6	IPR018980
Domain	FERM_N	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	1.88e-08	33	99	6	PF09379
Domain	FERM_N	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	1.88e-08	33	99	6	IPR018979
Domain	Na/H_exchanger_6	SLC9A9 SLC9A7 SLC9A6	1.44e-07	3	99	3	IPR002090
Domain	FERM_M	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	1.50e-07	46	99	6	PF00373
Domain	-	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.21e-07	49	99	6	1.20.80.10
Domain	FERM_central	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.21e-07	49	99	6	IPR019748
Domain	FERM_domain	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.21e-07	49	99	6	IPR000299
Domain	FERM_1	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	PS00660
Domain	FERM_2	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	PS00661
Domain	FERM_3	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	PS50057
Domain	Band_41_domain	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	IPR019749
Domain	B41	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	2.50e-07	50	99	6	IPR014352
Domain	Band_4.1_C	EPB41L3 EPB41 EPB41L1	5.76e-07	4	99	3	IPR008379
Domain	4_1_CTD	EPB41L3 EPB41 EPB41L1	5.76e-07	4	99	3	PF05902
Domain	SAB_dom	EPB41L3 EPB41 EPB41L1	5.76e-07	4	99	3	IPR007477
Domain	SAB	EPB41L3 EPB41 EPB41L1	5.76e-07	4	99	3	PF04382
Domain	NaH_exchanger	SLC9A9 SLC9A7 SLC9A6	1.19e-05	9	99	3	IPR004709
Domain	Cation/H_exchanger_CPA1	SLC9A9 SLC9A7 SLC9A6	2.31e-05	11	99	3	IPR018422
Domain	Na_H_Exchanger	SLC9A9 SLC9A7 SLC9A6	5.04e-05	14	99	3	PF00999
Domain	Cation/H_exchanger	SLC9A9 SLC9A7 SLC9A6	5.04e-05	14	99	3	IPR006153
Domain	Ubiquitin-rel_dom	EPB41L5 EPB41L3 PTPN4 PIK3CD FARP1 EPB41 EPB41L1	5.58e-05	184	99	7	IPR029071
Domain	DNA_ligase_ATP-dep_C	LIG3 LIG4	8.32e-05	3	99	2	IPR012309
Domain	DNA_ligase_ATP-dep_N	LIG3 LIG4	8.32e-05	3	99	2	IPR012308
Domain	DNA_ligase_ATP-dep_cent	LIG3 LIG4	8.32e-05	3	99	2	IPR012310
Domain	-	LIG3 LIG4	8.32e-05	3	99	2	1.10.3260.10
Domain	DNA_LIGASE_A2	LIG3 LIG4	8.32e-05	3	99	2	PS00333
Domain	DNA_LIGASE_A1	LIG3 LIG4	8.32e-05	3	99	2	PS00697
Domain	DNA_LIGASE_A3	LIG3 LIG4	8.32e-05	3	99	2	PS50160
Domain	DNA_ligase_ATP-dep	LIG3 LIG4	8.32e-05	3	99	2	IPR000977
Domain	DNA_ligase_ATP-dep_CS	LIG3 LIG4	8.32e-05	3	99	2	IPR016059
Domain	DNA_ligase_A_C	LIG3 LIG4	8.32e-05	3	99	2	PF04679
Domain	DNA_ligase_A_N	LIG3 LIG4	8.32e-05	3	99	2	PF04675
Domain	DNA_ligase_A_M	LIG3 LIG4	8.32e-05	3	99	2	PF01068
Domain	ARM-type_fold	VPS11 HIP1 USP9X HEATR1 USP9Y AOPEP PIK3CD AP1G2	4.43e-04	339	99	8	IPR016024
Domain	LIM	MICAL1 LHX4 LMCD1 LHX3	4.93e-04	69	99	4	PF00412
Domain	-	MICAL1 LHX4 LMCD1 LHX3	5.21e-04	70	99	4	2.10.110.10
Domain	Znf_LIM	MICAL1 LHX4 LMCD1 LHX3	5.50e-04	71	99	4	IPR001781
Domain	LIM_DOMAIN_1	MICAL1 LHX4 LMCD1 LHX3	5.50e-04	71	99	4	PS00478
Domain	LIM_DOMAIN_2	MICAL1 LHX4 LMCD1 LHX3	5.50e-04	71	99	4	PS50023
Domain	LIM	MICAL1 LHX4 LMCD1 LHX3	5.50e-04	71	99	4	SM00132
Domain	KRAB	ZNF268 ZNF772 ZNF224 ZNF785 ZNF331 ZNF620 ZNF799	2.95e-03	358	99	7	PS50805
Domain	KRAB	ZNF268 ZNF772 ZNF224 ZNF785 ZNF331 ZNF620 ZNF799	2.95e-03	358	99	7	PF01352
Domain	KRAB	ZNF268 ZNF772 ZNF224 ZNF785 ZNF331 ZNF620 ZNF799	3.49e-03	369	99	7	SM00349
Domain	KRAB	ZNF268 ZNF772 ZNF224 ZNF785 ZNF331 ZNF620 ZNF799	3.54e-03	370	99	7	IPR001909
Domain	A/G_cyclase_CS	ADCY3 GUCY2F	3.59e-03	17	99	2	IPR018297
Domain	Nucleotide_cyclase	ADCY3 GUCY2F	4.03e-03	18	99	2	IPR029787
Domain	-	ADCY3 GUCY2F	4.03e-03	18	99	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY3 GUCY2F	4.48e-03	19	99	2	PS00452
Domain	Guanylate_cyc	ADCY3 GUCY2F	4.48e-03	19	99	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY3 GUCY2F	4.48e-03	19	99	2	PS50125
Domain	A/G_cyclase	ADCY3 GUCY2F	4.48e-03	19	99	2	IPR001054
Domain	CYCc	ADCY3 GUCY2F	4.48e-03	19	99	2	SM00044
Domain	RHO	RHOBTB1 RHOBTB2	4.97e-03	20	99	2	PS51420
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A9 SLC9A7 SLC9A6	1.50e-05	9	81	3	M27337
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A9 SLC9A7 SLC9A6	1.50e-05	9	81	3	MM15079
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	DLGAP1 EPB41L5 EPB41L3 EPB41 EPB41L1	1.68e-05	56	81	5	M27616
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	DLGAP1 EPB41L5 EPB41L3 EPB41	3.22e-05	32	81	4	MM15326
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	DLGAP1 EPB41L5 EPB41L3 EPB41 EPB41L1	1.41e-04	87	81	5	M27617
Pubmed	Structural diversity of band 4.1 superfamily members.	EPB41L5 EPB41L3 EPB41 EPB41L1	5.23e-09	8	104	4	7983158
Pubmed	Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.	SLC9A9 SLC9A7 SLC9A6	1.04e-07	4	104	3	21171650
Pubmed	Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.	EPB41L3 EPB41 EPB41L1	1.04e-07	4	104	3	15834631
Pubmed	Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein.	EPB41L3 EPB41 EPB41L1	2.59e-07	5	104	3	12574408
Pubmed	Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation.	SLC9A9 SLC9A7 SLC9A6	2.59e-07	5	104	3	15522866
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	PTPRU EPB41L3 EPB41 EPB41L1	3.52e-07	20	104	4	9828140
Pubmed	New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.	EPB41L3 EPB41 EPB41L1	7.27e-06	13	104	3	16368544
Pubmed	Genes for endosomal pH regulators NHE6 and NHE9 are dysregulated in the substantia nigra in Parkinson's disease.	SLC9A9 SLC9A6	8.86e-06	2	104	2	38945311
Pubmed	A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes.	SLC9A7 SLC9A6	8.86e-06	2	104	2	20364249
Pubmed	Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.	SLC9A7 SLC9A6	8.86e-06	2	104	2	11279194
Pubmed	Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.	LHX4 LHX3	8.86e-06	2	104	2	12684778
Pubmed	Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.	LHX4 LHX3	8.86e-06	2	104	2	38970652
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	8.86e-06	2	104	2	12925892
Pubmed	Protein 4.1 and the control of ion channels.	EPB41 EPB41L1	8.86e-06	2	104	2	19272819
Pubmed	Genes for endosomal NHE6 and NHE9 are misregulated in autism brains.	SLC9A9 SLC9A6	8.86e-06	2	104	2	23508127
Pubmed	The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.	EPB41L3 EPB41	8.86e-06	2	104	2	23109359
Pubmed	DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells.	LIG3 LIG4	8.86e-06	2	104	2	24837021
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	8.86e-06	2	104	2	12895410
Pubmed	Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.	LHX4 LHX3	8.86e-06	2	104	2	15567726
Pubmed	Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.	XCR1 CCR1	8.86e-06	2	104	2	7683036
Pubmed	Low levels of DNA ligases III and IV sufficient for effective NHEJ.	LIG3 LIG4	8.86e-06	2	104	2	17492771
Pubmed	Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.	SLC9A9 SLC9A6	8.86e-06	2	104	2	17005858
Pubmed	Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.	LIG3 LIG4	8.86e-06	2	104	2	7760816
Pubmed	Alterations of protein 4.1 family members in ependymomas: a study of 84 cases.	EPB41L3 EPB41	8.86e-06	2	104	2	15731777
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	8.86e-06	2	104	2	8922996
Pubmed	Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.	SLC9A9 SLC9A7 SLC9A6	2.05e-05	18	104	3	24874739
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E HIP1 RHBDF2 SFI1 ITGA5 SH3BP4 POMGNT2 PIK3CD BTBD7 LRP4 AP1G2 IQGAP3 PLK3	2.64e-05	1105	104	13	35748872
Pubmed	DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.	LIG3 LIG4	2.65e-05	3	104	2	11896201
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	2.65e-05	3	104	2	11222756
Pubmed	DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.	LIG3 LIG4	2.65e-05	3	104	2	21655080
Pubmed	Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.	LHX4 LHX3	2.65e-05	3	104	2	10788441
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	2.65e-05	3	104	2	27314390
Pubmed	Protein 4.1 expression in the developing hair cells of the mouse inner ear.	EPB41L3 EPB41	2.65e-05	3	104	2	19853587
Pubmed	Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.	SLC9A9 SLC9A6	2.65e-05	3	104	2	18057008
Pubmed	Altered DNA ligase activity in human disease.	LIG3 LIG4	2.65e-05	3	104	2	31630206
Pubmed	Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.	PDE1C ADCY3	2.65e-05	3	104	2	26942602
Pubmed	Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.	LHX4 LHX3	2.65e-05	3	104	2	18425848
Pubmed	Autosomal Dominant Epilepsy with Auditory Features	MICAL1 RELN	2.65e-05	3	104	2	20301709
Pubmed	Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair.	LIG3 LIG4	2.65e-05	3	104	2	19589734
Pubmed	Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.	EPB41L3 EPB41	2.65e-05	3	104	2	22429617
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	2.65e-05	3	104	2	12426103
Pubmed	Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks.	LIG3 LIG4	2.65e-05	3	104	2	18440984
Pubmed	Human DNA ligases in replication and repair.	LIG3 LIG4	2.65e-05	3	104	2	33087274
Pubmed	Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.	RELN GOLGA8K POMGNT2	5.02e-05	24	104	3	26060116
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	PTPRU EPB41	5.29e-05	4	104	2	9434160
Pubmed	DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.	LIG3 LIG4	5.29e-05	4	104	2	9809069
Pubmed	Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres.	EPB41L3 EPB41	5.29e-05	4	104	2	12542678
Pubmed	Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.	LHX4 LHX3	5.29e-05	4	104	2	22025611
Pubmed	SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.	USP9X SFI1	5.29e-05	4	104	2	31197030
Pubmed	Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).	LIG3 LIG4	5.29e-05	4	104	2	22308491
Pubmed	HELB Is a Feedback Inhibitor of DNA End Resection.	HELB LIG4	5.29e-05	4	104	2	26774285
Pubmed	Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.	RHOBTB1 RHOBTB2	8.80e-05	5	104	2	18835386
Pubmed	Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.	LHX4 LHX3	8.80e-05	5	104	2	15607939
Pubmed	Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.	ITGA5 MX1	8.80e-05	5	104	2	29530483
Pubmed	Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.	XCR1 CCR1	8.80e-05	5	104	2	17135764
Pubmed	Band 4.1 proteins regulate integrin-dependent cell spreading.	EPB41L3 EPB41L1	8.80e-05	5	104	2	22982319
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	USP9X EPB41L5 HEATR1 EPB41L3 AAAS FARP1 EPB41 EPB41L1	1.29e-04	498	104	8	36634849
Pubmed	Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.	LHX4 LHX3	1.32e-04	6	104	2	20534763
Pubmed	DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.	LIG3 LIG4	1.32e-04	6	104	2	21390131
Pubmed	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.	RHOBTB1 RHOBTB2	1.32e-04	6	104	2	22709582
Pubmed	Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.	XCR1 CCR1	1.32e-04	6	104	2	10702689
Pubmed	Endothelial Cyp26b1 restrains murine heart valve growth during development.	HIP1 ITGA5 LRIG1 AOPEP PRKCH	1.35e-04	163	104	5	35364055
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	EPB41L5 EPB41L3 ADCY3 SH3BP4 FARP1 EPB41 EPB41L1	1.43e-04	377	104	7	38117590
Pubmed	DNA repair gene polymorphisms and risk of pancreatic cancer.	LIG3 LIG4	1.84e-04	7	104	2	19147782
Pubmed	Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene.	LHX4 LHX3	1.84e-04	7	104	2	14714741
Pubmed	The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.	PTPRU PRKCH	1.84e-04	7	104	2	11781100
Pubmed	D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N.	EPB41 EPB41L1	1.84e-04	7	104	2	12181426
Pubmed	Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.	RHOBTB1 RHOBTB2	2.45e-04	8	104	2	24923387
Pubmed	β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.	EPB41L3 EPB41	2.45e-04	8	104	2	21181944
Pubmed	Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.	RELN GOLGA8K SOCS4	2.74e-04	42	104	3	24210661
Pubmed	Formation of Rathke's pouch requires dual induction from the diencephalon.	LHX4 LHX3	3.14e-04	9	104	2	9806931
Pubmed	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	ZNF268 ZNF224	3.14e-04	9	104	2	23665872
Pubmed	Analysis of cDNA sequences from mouse testis.	SPTLC2 EPB41L3	3.92e-04	10	104	2	8000140
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	RELN ADCY3	3.92e-04	10	104	2	16615126
Pubmed	Implication of geranylgeranyltransferase I in synapse formation.	FARP1 LRP4	3.92e-04	10	104	2	14622576
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	3.92e-04	10	104	2	9384609
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DLGAP1 EPB41L3 LIG3 PTPN4 PIK3CD GPR45	4.77e-04	329	104	6	17474147
Pubmed	Vax genes ventralize the embryonic eye.	DCT GLUL	4.79e-04	11	104	2	15905411
Pubmed	Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.	LHX4 LHX3	4.79e-04	11	104	2	25668206
Pubmed	Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons.	RELN LHX4	4.79e-04	11	104	2	15703280
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RHBDF2 ST7 RTN4RL1 ADCY3 SH3BP4 ZNF331 PTPN4 AOPEP FARP1 SLC9A7 EPB41 EPB41L1 DOP1A	5.04e-04	1489	104	13	28611215
Pubmed	Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.	XCR1 MX1	5.73e-04	12	104	2	29632368
Pubmed	Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice.	RELN GLUL	5.73e-04	12	104	2	23828756
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	5.73e-04	12	104	2	23861879
Pubmed	Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.	LHX4 LHX3	5.73e-04	12	104	2	8638120
Pubmed	Molecular basis of pituitary dysfunction in mouse and human.	LHX4 LHX3	5.73e-04	12	104	2	11420609
Pubmed	Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.	LHX4 LHX3	5.73e-04	12	104	2	15053981
Pubmed	Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.	RELN RBL1	5.73e-04	12	104	2	24056077
Pubmed	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.	RELN GLUL	6.76e-04	13	104	2	25285789
Pubmed	LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.	LHX4 LHX3	6.76e-04	13	104	2	9865699
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SPTLC2 EPB41L5 EPB41L3 RHOBTB1 FIG4 DNAH17 DOP1A	7.18e-04	493	104	7	15368895
Pubmed	Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.	DLGAP1 SLC9A9 RUNDC3B LRIG1	7.19e-04	134	104	4	24324551
Pubmed	Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.	RELN ADCY3	7.87e-04	14	104	2	22442076
Pubmed	Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus.	RELN ADCY3	7.87e-04	14	104	2	23447624
Pubmed	SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.	ITGA5 SH3BP4	7.87e-04	14	104	2	33761321
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RUNDC3B ST7 ITGA5 SH3BP4 AAAS LRIG1 FIG4	8.16e-04	504	104	7	34432599
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP9Y	9.07e-04	15	104	2	9827704
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	PIEZO2 MRGPRX3	9.07e-04	15	104	2	37541195
Pubmed	Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.	SLC9A9 SLC9A6	9.07e-04	15	104	2	24035762
Pubmed	Hippocampals neurogenesis is impaired in mice with a deletion in the coiled coil domain of Talpid3-implications for Joubert syndrome.	RELN ADCY3	9.07e-04	15	104	2	35470378
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L5 EPB41L3 PTPN4 FARP1 EPB41 EPB41L1	3.45e-08	50	69	6	1293
GeneFamily	Erythrocyte membrane protein band 4.1\|FERM domain containing	EPB41L3 EPB41 EPB41L1	2.12e-07	4	69	3	951
GeneFamily	DNA ligases\|Nucleotide excision repair	LIG3 LIG4	4.30e-05	3	69	2	1247
GeneFamily	LIM class homeoboxes	LHX4 LHX3	9.24e-04	12	69	2	522
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	MYO1G HEATR1 USP9Y	9.72e-04	51	69	3	870
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	2.61e-03	20	69	2	390
ToppCell	NS-moderate-d_0-4-Myeloid-Non-resident_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYO1G FSCN3 ITGA5 EPB41L3 DNAH17 CCR1	5.15e-06	187	104	6	fcc32dbc9c5ae6176f154715a3e73aa32d78ad64
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SFI1 HELB PIK3CD PRKCH NLRC3 EPB41	5.47e-06	189	104	6	df30478b288084a1bd48f660409dcc784040897c
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G USP9X SFI1 PTPRU PIEZO2 BTBD7	5.99e-06	192	104	6	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 EPB41L5 RHOBTB1 AOPEP FARP1 EPB41L1	6.35e-06	194	104	6	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRC8E MYO1G SLC9A9 AAAS RHOBTB1	1.47e-05	132	104	5	a1fda8c5287168c4f159203ed27cadfb4ce1b131
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LMCD1 DCT SH3BP4 GUCY2F LRP4	1.52e-05	133	104	5	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	USP9Y DCT GUCY2F PJVK	3.37e-05	78	104	4	87ed71a692416a21c8c11b5adbfe629f7d57ddb4
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4-_Ptgds_(Bmp4)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	USP9Y DCT GUCY2F PJVK	3.37e-05	78	104	4	9545ae56fda3893b82b5efa82082e1f585a5f92a
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE1C HEATR1 DCT FARP1 KIAA1755	5.51e-05	174	104	5	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	XCR1 SLC9A9 SFI1 ADCY3 EPB41	5.82e-05	176	104	5	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	SFI1 HEATR1 ZNF224 AGO3 SLC9A6	5.82e-05	176	104	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIP1 ST7 ADCY3 SH3BP4 SLC9A7	5.98e-05	177	104	5	cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	MMS22L SFI1 ZNF224 AGO3 SLC9A6	5.98e-05	177	104	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIP1 ST7 ADCY3 SH3BP4 SLC9A7	6.14e-05	178	104	5	04bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCell	Immune_cells-Dendritic_cells\|Immune_cells / Lineage and Cell class	SLC9A9 FBXL13 RTN4RL1 SH3BP4 PNCK	6.82e-05	182	104	5	99c7d4f1e7cd745643ba64b59190113bcd4e348e
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G PTPN4 PIK3CD PRKCH NLRC3	6.82e-05	182	104	5	09d0793245d3d77ab5fc384c0b62637f736da50b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RBL1 SFI1 HELB PTPN4 PRKCH	7.00e-05	183	104	5	f2ef110bf29b1a8276ef216238363e542db262c1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C RELN SFI1 PIEZO2 GUCY2F	7.18e-05	184	104	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C RELN SFI1 PIEZO2 GUCY2F	7.18e-05	184	104	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C RELN SFI1 PIEZO2 GUCY2F	7.18e-05	184	104	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 PIEZO2 GLUL LRP4 KIAA1755	7.37e-05	185	104	5	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN LMCD1 RNF215 LIG3 PRKCH	7.37e-05	185	104	5	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 PIEZO2 GLUL LRP4 KIAA1755	7.75e-05	187	104	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 SH3BP4 PIEZO2 LRP4 KIAA1755	7.95e-05	188	104	5	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 SH3BP4 PIEZO2 GLUL KIAA1755	8.15e-05	189	104	5	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN RTN4RL1 PIEZO2 PRKCH	8.35e-05	190	104	5	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN RTN4RL1 PIEZO2 PRKCH	8.35e-05	190	104	5	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN RTN4RL1 PIEZO2 PRKCH	8.35e-05	190	104	5	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 PIEZO2 GLUL LRP4 KIAA1755	8.35e-05	190	104	5	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	SLC9A9 RHBDF2 SPTLC2 EPB41L3 PIK3CD	8.56e-05	191	104	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 PIEZO2 GLUL LRP4 KIAA1755	8.56e-05	191	104	5	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	HELB PIK3CD PRKCH NLRC3 EPB41	8.56e-05	191	104	5	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SFI1 HELB PIK3CD PRKCH NLRC3	8.77e-05	192	104	5	1c0ce299cee9ab5cdea256f3e8c1e5598577a8b6
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HELB PIK3CD PRKCH NLRC3 EPB41	8.77e-05	192	104	5	69a2b04f03a1b82d067018379f7b8a116e954040
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	SLC9A9 RHBDF2 SPTLC2 EPB41L3 PIK3CD	8.77e-05	192	104	5	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1C RELN PTPRU PIEZO2 FARP1	8.99e-05	193	104	5	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFI1 USP9Y HELB EPB41 MX1	8.99e-05	193	104	5	2901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	SLC9A9 RHBDF2 SPTLC2 EPB41L3 PIK3CD	8.99e-05	193	104	5	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Severe / Disease group, lineage and cell class	SFI1 USP9Y HELB EPB41 MX1	8.99e-05	193	104	5	beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFI1 USP9Y HELB EPB41 MX1	8.99e-05	193	104	5	f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFI1 USP9Y HELB EPB41 MX1	8.99e-05	193	104	5	f8af695457d2a0a911a5ac491742465864ebda37
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SFI1 USP9Y HELB EPB41 MX1	8.99e-05	193	104	5	089aece40130034a89a5213be778f10b0787eeba
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYO1G RHBDF2 EPB41L3 ZNF331 GLUL	9.21e-05	194	104	5	3043f6230fa723037c8cf7123f611ae847b39fd4
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HELB PIK3CD PRKCH NLRC3 EPB41	9.21e-05	194	104	5	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1C RELN PIEZO2 PIK3CD FARP1	9.21e-05	194	104	5	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC9A9 RHBDF2 EPB41L3 GLUL CCR1	9.44e-05	195	104	5	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	OGFR HELB CCR1 MX1 DOP1A	9.67e-05	196	104	5	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LMCD1 AOPEP FARP1 LRP4 KIAA1755	9.90e-05	197	104	5	2e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCell	COVID-19-Myeloid-MoAM1,_IL1R2\|COVID-19 / Condition, Lineage and Cell class	RHBDF2 SPTLC2 GLUL CCR1 MX1	9.90e-05	197	104	5	4a9c61b37c938bb26929593007d713382ae1eb79
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PDE1C RUNDC3B PCDHGA1 ZNF772 RHOBTB2	9.90e-05	197	104	5	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D231\|Adult / Lineage, Cell type, age group and donor	EPB41L3 ADCY3 ZNF331 GLUL SESN2	1.01e-04	198	104	5	79a415e19cedde13a88f5043d71557363f102322
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	MICAL1 EPB41L5 PTPRU EPB41L3 FARP1	1.01e-04	198	104	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LMCD1 AOPEP FARP1 LRP4 KIAA1755	1.01e-04	198	104	5	4a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EPB41L3 PIEZO2 RHOBTB1 GLUL CCR1	1.01e-04	198	104	5	9aaff68107ae4542f904b142d23669f2fcd557ac
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EPB41L3 PIEZO2 RHOBTB1 GLUL CCR1	1.01e-04	198	104	5	5aaf3861c53763cf09bb628c9d2eabb6a7277021
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFI1 USP9Y HELB PRKCH EPB41	1.04e-04	199	104	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	control-CD163+_Monocytes_(Sample_ID1_d7)\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SPTLC2 EPB41L3 GLUL CCR1 MX1	1.04e-04	199	104	5	933201d32eda12a89660bdbae9114a95cc428a38
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LMCD1 PIEZO2 FARP1 LRP4 KIAA1755	1.04e-04	199	104	5	edba1833ef5c4ca122d7c32f97670314e005f93b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RHBDF2 SPTLC2 ITGA5 PRKCH PLK3	1.04e-04	199	104	5	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DLGAP1 PDE1C RELN PTPRU PIEZO2	1.06e-04	200	104	5	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DLGAP1 PDE1C RELN PTPRU PIEZO2	1.06e-04	200	104	5	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	mild-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SPTLC2 EPB41L3 GLUL CCR1 MX1	1.06e-04	200	104	5	82126e25bfd8fba78dc1348fa5ad6a576289a139
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DLGAP1 PDE1C RELN PTPRU PIEZO2	1.06e-04	200	104	5	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Severe / Disease, condition lineage and cell class	SFI1 USP9Y HELB EPB41 MX1	1.06e-04	200	104	5	deeed668b129e66156b5f6abe1a07a9bf842a14d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYO1G MICAL1 RHBDF2 ZNF331 PLK3	1.06e-04	200	104	5	74ceebee9af63f8b3ec5857eff1b662752bc3862
Drug	estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A	LHX3 ZNF224 DNAH17 AP1G2 OAZ3 PLK3 MX1 DOP1A	2.67e-06	196	101	8	5955_DN
Drug	Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; PC3; HT_HG-U133A	MICAL1 PDE1C RHBDF2 ZNF268 OGFR LIG3 RHOBTB2 LRP4	2.67e-06	196	101	8	4083_DN
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	HIP1 SPTLC2 ST7 ADCY3 LRIG1 BTBD7 PRKCH OAZ3	2.98e-06	199	101	8	7338_DN
Drug	pay off	PTPRU GUCY2F SLC9A7 SESN2 SLC9A6	6.44e-06	59	101	5	CID000050980
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	1.16e-05	2	101	2	DOID:0070375 (implicated_via_orthology)
Disease	Autosomal dominant epilepsy with auditory features	MICAL1 RELN	3.47e-05	3	101	2	cv:C1838062
Disease	EPILEPSY, FAMILIAL TEMPORAL LOBE, 1	MICAL1 RELN	3.47e-05	3	101	2	600512
Disease	Epilepsy, Familial Temporal Lobe 1	MICAL1 RELN	3.47e-05	3	101	2	C4551957
Disease	Epilepsy, familial temporal lobe, 1	MICAL1 RELN	3.47e-05	3	101	2	cv:C4551957
Disease	inflammatory bowel disease (implicated_via_orthology)	EPB41L3 EPB41 EPB41L1	8.48e-05	25	101	3	DOID:0050589 (implicated_via_orthology)
Disease	Combined pituitary hormone deficiencies, genetic form	LHX4 LHX3	1.15e-04	5	101	2	cv:C4273747
Disease	panhypopituitarism (is_implicated_in)	LHX4 LHX3	2.41e-04	7	101	2	DOID:9410 (is_implicated_in)
Disease	X-12844 measurement	SLC22A25 ZNF799	4.11e-04	9	101	2	EFO_0021339
Disease	plasma trimethylamine N-oxide measurement	FIG4 RHOBTB2	5.13e-04	10	101	2	EFO_0005691
Disease	Drug habituation	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0013170
Disease	Substance-Related Disorders	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0236969
Disease	Drug abuse	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0013146
Disease	Drug Use Disorders	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0013222
Disease	Drug Dependence	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C1510472
Disease	Substance Dependence	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0038580
Disease	Substance Use Disorders	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C0029231
Disease	Prescription Drug Abuse	PDE1C ZNF804A FARP1 PRKCH	6.68e-04	115	101	4	C4316881
Disease	Substance abuse problem	PDE1C ZNF804A FARP1 PRKCH	6.90e-04	116	101	4	C0740858
Disease	Charcot-Marie-Tooth Disease	SPTLC2 FIG4	7.49e-04	12	101	2	C0007959
Disease	dystonia (is_implicated_in)	VPS11 AOPEP	1.03e-03	14	101	2	DOID:543 (is_implicated_in)
Disease	macrophage inflammatory protein 1b measurement	SLC22A25 LIG3 POMGNT2 POLR1E	1.25e-03	136	101	4	EFO_0008219
Disease	Schizoaffective disorder-bipolar type	MYO1G ZNF804A	1.35e-03	16	101	2	EFO_0009965
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PDE1C MMS22L RELN RTN4RL1 ADCY3 LRIG1	1.60e-03	364	101	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	temporal lobe epilepsy (is_marker_for)	RELN GLUL	2.12e-03	20	101	2	DOID:3328 (is_marker_for)
Disease	non-melanoma skin carcinoma	STK35 GUCY2F FARP1 EPB41 EPB41L1	2.21e-03	265	101	5	EFO_0009260
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	PDE1C MMS22L FSCN3 PTPRU ZNF804A ZNF799	2.51e-03	398	101	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	Mood Disorders	RELN ZNF804A ADCY3 GLUL	2.70e-03	168	101	4	C0525045
Disease	Sarcosine measurement	PCDHGA2 PCDHGA1	2.80e-03	23	101	2	EFO_0021668
Disease	antiphospholipid syndrome	PTPRU SH3BP4	3.05e-03	24	101	2	EFO_0002689
Disease	mental development measurement	PCDHGA2 PCDHGA1	3.31e-03	25	101	2	EFO_0008230
Disease	Fanconi Anemia	RAD51C MX1	3.31e-03	25	101	2	C0015625

Protein segments in the cluster

Peptide	Gene	Start	Entry
EWKLCRSARHFLHHY	C22orf39	56	Q6P5X5
LWKVCVEHHTFFRLT	EPB41	476	P11171
RTAFIHHREQVWKRC	AAAS	66	Q9NRG9
FSRHRVWSLLKEHKV	ABCA10	561	Q8WWZ4
STHSLCWKLRFRIIH	ANKK1	111	Q8NFD2
CWKLRFRIIHETSLA	ANKK1	116	Q8NFD2
RFAPTKRWHIDTILH	AP1G2	411	O75843
RSVCHRDGHWFLKLL	DLGAP1	786	O14490
AKFAVLWHLTRDLHI	DOP1A	931	Q5JWR5
RLCHEIAHAWFGLAI	AOPEP	476	Q8N6M6
KFVSRVSWHLLHEVL	AGO3	126	Q9H9G7
WVHHKAFHDLRRLTT	RTN4RL1	211	Q86UN2
GHAATIRLIFHWDRK	RAD51C	306	O43502
AFVIVLLAHRLRRWH	PCDHGA2	706	Q9Y5H1
NLWKACVEHHTFFRL	PTPN4	296	P29074
KRLWKVCIEHHTFFR	EPB41L1	361	Q9H4G0
TSAHWHGLLCDRRLF	OAZ3	131	Q9UMX2
ELCFIHHWRDRRHQK	GOLGA8T	476	H3BQL2
ARIHRKGWSFCQKLH	LRIG1	296	Q96JA1
KTTLVRHFVRLWAHG	NLRC3	151	Q7RTR2
ETLLHLHRFCKRMTW	KIAA1755	956	Q5JYT7
KERHLAAVASALWRH	MMS22L	706	Q6ZRQ5
RHFLETHDARTKRLW	KIAA1109	1096	Q2LD37
LHHRWTMSLLEEFFR	PDE1C	386	Q14123
PVFDTVFIRRKHWHR	FAM169B	76	Q8N8A8
RFILKALDRHWHSKC	LHX3	41	Q9UBR4
FILKVLDRHWHSSCL	LHX4	41	Q969G2
RTKFSRHNVLHLWPF	MICAL1	116	Q8TDZ2
FQHCRKLVTLRLWHN	LRRC8E	626	Q6NSJ5
RIHLDWKVLFCHVHL	MRGPRX3	241	Q96LB0
AAVLWKHVRLREHAA	POMGNT2	16	Q8NAT1
LSRKELCLFRKHHWR	LIG3	16	P49916
LCLFRKHHWRDVRQF	LIG3	21	P49916
ITVRWHFGDHFCRLS	GPR45	96	Q9Y5Y3
VRQKFAEHSHFLRTW	IQGAP3	746	Q86VI3
QRVEDLAWHRKHFVC	LMCD1	321	Q9NZU5
GWRREVVHFGKLHLC	RELN	2086	P78509
EGHLLVRHFQFLRWS	PTPRU	1331	Q92729
HWKRAFNATSFLRHI	PNCK	296	Q6P2M8
LHFRVWAKTFLQREH	ITGA5	936	P08648
HLLAFATKRIWIHRR	FAM157B	161	P0CG42
HLWKCAVEHHAFFRL	EPB41L5	311	Q9HCM4
LVKKELCFIHHWRDR	GOLGA8K	471	D6RF30
LCFIHHWRDRRHQKT	GOLGA8K	476	D6RF30
IRHFREFLDSWRKFH	LIG4	36	P49917
QLRHRWDEEKRHCFA	DNAH17	1786	Q9UFH2
FHRRVAVHLVKWLPF	CCR1	316	P32246
WKICVEHHAFFRLFE	FARP1	306	Q9Y4F1
TVHRDWLLYIIHGFC	FIG4	241	Q92562
LVLWFAAFRKLLGHH	GUCY2F	11	P51841
HHGCFLLRFHRNSKW	FSCN3	91	Q9NQT6
FSRHVEKLARTLFLW	ADCY3	856	O60266
HLVKTHFCTWRDIAR	FBXL13	16	Q8NEE6
KWVHRQALHFLCEEF	BTBD7	416	Q9P203
QKCLEWLIHRFHIHL	HEATR1	111	Q9H583
RLAHHRWLLFFHFGK	DNAJC10	361	Q8IXB1
EKCRRFVHPQWKLIH	SLC22A25	86	Q6T423
KWSRHRRLLTPAFHF	CYP4F22	151	Q6NT55
RAAKRLWKVCVEHHT	EPB41L3	371	Q9Y2J2
CRIKHAWARTIHTFQ	HELB	876	Q8NG08
AFVIVLLAHRLRRWH	PCDHGA1	706	Q9Y5H4
VHFAWEHFRPRCKFV	OGFR	271	Q9NZT2
CIWFLDTLIKFRAHR	POLR1E	276	Q9GZS1
DHLWVARFILHRVCE	GLUL	216	P15104
HRLKEISQSCRWLAH	RUNDC3B	76	Q96NL0
LARWKTHHLQCVRKR	SFI1	791	A8K8P3
NLFWRHFRHSEKVHV	SESN2	441	P58004
ILLRHSKNVRFWFAH	USP9X	2076	Q93008
LTIWLFKHRRARFLH	SLC9A6	86	Q92581
LTIWLFKNHRFRFLH	SLC9A9	36	Q8IVB4
AWLNHRKLARSCHDL	SH3BP4	286	Q9P0V3
LRRKIWTCFEFTLVH	RBL1	816	P28749
LCWKFCHVFHKLLRD	HIP1	91	O00291
RLWDTFGDHHKDRRF	RHOBTB2	81	Q9BYZ6
AALISRRHLQFWKSH	RHOBTB2	206	Q9BYZ6
QWLRVLPCKHEFHRD	RNF215	336	Q9Y6U7
PRSDLAFRWHFIKRH	SOCS4	136	Q8WXH5
AFRWHFIKRHTAPIN	SOCS4	141	Q8WXH5
HHRFITEKRVFSSWA	ST6GALNAC6	306	Q969X2
RLWDTFGDHHKDRRF	RHOBTB1	81	O94844
AALISRRHLQFWKSH	RHOBTB1	206	O94844
FFHLAHWKRVEGALN	ST7	446	Q9NRC1
RFRTLWGIHKSFHNI	ACSM1	6	Q08AH1
LCSRKSLAHIWKARH	PLK3	141	Q9H4B4
THLKHVLRQFWFCRL	XCR1	296	P46094
RLCKGLSWREHVESH	STK35	21	Q8TDR2
CFAFEGHKLIAHWFR	VPS11	266	Q9H270
AFIWKSLLIVHERTH	ZNF268	816	Q14587
AAHAWRTLFFLCKGH	TMEM179	86	Q6ZVK1
VRLHAVPCFDIWHKR	PJVK	336	Q0ZLH3
LRYWRIEKCHHATER	SPTLC2	91	O15270
FSWCGRFILHQKLHT	ZNF620	401	Q6ZNG0
LFFHRSILKCHGLWD	PIEZO2	2026	Q9H5I5
FRWGSSLVIHKRIHT	ZNF331	196	Q9NQX6
FRWGSSLVKHERIHT	ZNF331	336	Q9NQX6
FSWLTCFLRHERIHM	ZNF799	541	Q96GE5
RALANRKIGHFLFWH	PIK3CD	636	O00329
RKIGHFLFWHLRSEM	PIK3CD	641	O00329
WKFEIHRCIINNTHR	USP9Y	141	O00507
CVILSRIIFGDHHWK	TTC23L	96	Q6PF05
RIIFGDHHWKCARAL	TTC23L	101	Q6PF05
FVTWHRYHLLCLERD	DCT	216	P40126
EHLWLTRHLRDPFVK	MRM2	31	Q9UI43
FRWASCLLKHQRVHS	ZNF224	381	Q9NZL3
LTIWLFKHRRVRFLH	SLC9A7	86	Q96T83
RLWLSLFLHAGVVHC	RHBDF2	656	Q6PJF5
FRQRASLIRHWKIHT	ZNF772	471	Q68DY9
RKTALEAHRWIHRSC	ZNF785	351	A8K8V0
RFHEHWRFVLQRLVF	TSN	86	Q15631
RLKETHEYWFHKSRR	ZNF804A	581	Q7Z570
FKHLRKWVVTRFFGH	KCNJ1	21	P48048
HAILRHPFFKEIDWA	PRKCH	606	P24723
IALDFHHRRELVFWS	LRP4	471	O75096
IRLFTRLRHEFHKWS	MX1	401	P20591
RWFRRHKVRAHLAEL	MYO1G	741	B0I1T2