Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	orexin receptor activity	HCRTR1 HCRTR2	3.58e-05	2	120	2	GO:0016499
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS2 NOS3	1.07e-04	3	120	2	GO:0004517
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS2 NOS3	2.13e-04	4	120	2	GO:0034617
GeneOntologyMolecularFunction	NADP binding	FMO3 HSD11B1 NOS2 NOS3	5.29e-04	62	120	4	GO:0050661
GeneOntologyMolecularFunction	gamma-aminobutyric acid:sodium:chloride symporter activity	SLC6A12 SLC6A13	5.29e-04	6	120	2	GO:0005332
GeneOntologyMolecularFunction	netrin receptor activity	UNC5B UNC5D	5.29e-04	6	120	2	GO:0005042
GeneOntologyCellularComponent	external side of plasma membrane	CFH CLEC6A PSG9 CR1L IZUMO1R TLR8 FCRL6 MS4A1 CD79B CD200R1L IL2RA LILRB5	4.48e-05	519	120	12	GO:0009897
GeneOntologyCellularComponent	PR-DUB complex	ASXL1 ASXL3	1.95e-04	4	120	2	GO:0035517
Domain	Sushi	CFH PAPPA2 CR1L CSMD3 SVEP1 NCAN IL2RA	2.63e-08	52	113	7	PF00084
Domain	CCP	CFH PAPPA2 CR1L CSMD3 SVEP1 NCAN IL2RA	3.45e-08	54	113	7	SM00032
Domain	SUSHI	CFH PAPPA2 CR1L CSMD3 SVEP1 NCAN IL2RA	4.47e-08	56	113	7	PS50923
Domain	Sushi_SCR_CCP_dom	CFH PAPPA2 CR1L CSMD3 SVEP1 NCAN IL2RA	5.07e-08	57	113	7	IPR000436
Domain	Orexin_rcpt	HCRTR1 HCRTR2	3.63e-05	2	113	2	IPR000204
Domain	Myotubularin-like_Pase_dom	MTMR4 SBF1 SBF2	7.48e-05	14	113	3	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR4 SBF1 SBF2	7.48e-05	14	113	3	PS51339
Domain	Myotubularin_fam	MTMR4 SBF1 SBF2	7.48e-05	14	113	3	IPR030564
Domain	Myotub-related	MTMR4 SBF1 SBF2	7.48e-05	14	113	3	PF06602
Domain	HARE-HTH	ASXL1 ASXL3	1.08e-04	3	113	2	PF05066
Domain	ASXH	ASXL1 ASXL3	1.08e-04	3	113	2	PF13919
Domain	PHD_3	ASXL1 ASXL3	1.08e-04	3	113	2	PF13922
Domain	NO_synthase	NOS2 NOS3	1.08e-04	3	113	2	PF02898
Domain	ASX-like_PHD	ASXL1 ASXL3	1.08e-04	3	113	2	IPR026905
Domain	ASXH	ASXL1 ASXL3	1.08e-04	3	113	2	IPR028020
Domain	NOS_euk	NOS2 NOS3	1.08e-04	3	113	2	IPR012144
Domain	-	NOS2 NOS3	1.08e-04	3	113	2	3.90.340.10
Domain	SBF2	SBF1 SBF2	1.08e-04	3	113	2	PF12335
Domain	ASX/ASX-like	ASXL1 ASXL3	1.08e-04	3	113	2	IPR024811
Domain	NOS_N	NOS2 NOS3	1.08e-04	3	113	2	IPR004030
Domain	HB1/Asxl_HTH	ASXL1 ASXL3	1.08e-04	3	113	2	IPR007759
Domain	NOS	NOS2 NOS3	1.08e-04	3	113	2	PS60001
Domain	SBF1/SBF2	SBF1 SBF2	1.08e-04	3	113	2	IPR022096
Domain	UPA	UNC5B UNC5D	3.59e-04	5	113	2	PF17217
Domain	UPA	UNC5B UNC5D	3.59e-04	5	113	2	IPR033772
Domain	BRK	CHD9 CHD8	5.36e-04	6	113	2	SM00592
Domain	FAD_binding_1	NOS2 NOS3	5.36e-04	6	113	2	PF00667
Domain	BRK_domain	CHD9 CHD8	5.36e-04	6	113	2	IPR006576
Domain	-	NOS2 NOS3	5.36e-04	6	113	2	1.20.990.10
Domain	FAD-binding_1	NOS2 NOS3	5.36e-04	6	113	2	IPR003097
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS2 NOS3	5.36e-04	6	113	2	IPR023173
Domain	BRK	CHD9 CHD8	5.36e-04	6	113	2	PF07533
Domain	TSP_1	UNC5B ADGRB2 ADAMTS18 UNC5D	5.75e-04	63	113	4	PF00090
Domain	TSP1	UNC5B ADGRB2 ADAMTS18 UNC5D	6.47e-04	65	113	4	SM00209
Domain	TSP1_rpt	UNC5B ADGRB2 ADAMTS18 UNC5D	6.47e-04	65	113	4	IPR000884
Domain	TSP1	UNC5B ADGRB2 ADAMTS18 UNC5D	6.47e-04	65	113	4	PS50092
Domain	Flavodoxin/NO_synth	NOS2 NOS3	9.92e-04	8	113	2	IPR008254
Domain	Flavdoxin-like	NOS2 NOS3	9.92e-04	8	113	2	IPR001094
Domain	FLAVODOXIN_LIKE	NOS2 NOS3	9.92e-04	8	113	2	PS50902
Domain	Flavodoxin_1	NOS2 NOS3	9.92e-04	8	113	2	PF00258
Domain	ZU5	UNC5B UNC5D	1.27e-03	9	113	2	SM00218
Domain	-	NOS2 NOS3	1.58e-03	10	113	2	3.40.50.360
Domain	Flavoprotein-like_dom	NOS2 NOS3	1.58e-03	10	113	2	IPR029039
Domain	ZU5	UNC5B UNC5D	1.58e-03	10	113	2	PS51145
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS2 NOS3	1.58e-03	10	113	2	IPR001709
Domain	AAA	DNAH3 DNAH10 ABCA13 AK9 HELZ2	1.83e-03	144	113	5	SM00382
Domain	AAA+_ATPase	DNAH3 DNAH10 ABCA13 AK9 HELZ2	1.83e-03	144	113	5	IPR003593
Domain	PTBI	DOK1 DOK4	1.93e-03	11	113	2	SM00310
Domain	OxRdtase_FAD/NAD-bd	NOS2 NOS3	2.30e-03	12	113	2	IPR001433
Domain	IRS_PTB	DOK1 DOK4	2.30e-03	12	113	2	PS51064
Domain	NAD_binding_1	NOS2 NOS3	2.30e-03	12	113	2	PF00175
Domain	ZU5	UNC5B UNC5D	2.30e-03	12	113	2	PF00791
Domain	ZU5_dom	UNC5B UNC5D	2.30e-03	12	113	2	IPR000906
Domain	IG_LIKE	SEMA3C PSG9 UNC5B FCRL6 NCAN CD79B CD200R1L LILRB5 UNC5D	2.97e-03	491	113	9	PS50835
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH10	3.15e-03	14	113	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH10	3.15e-03	14	113	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH10	3.15e-03	14	113	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH10	3.15e-03	14	113	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH10	3.15e-03	14	113	2	IPR011704
Domain	IRS	DOK1 DOK4	3.15e-03	14	113	2	PF02174
Domain	IRS_PTB	DOK1 DOK4	3.15e-03	14	113	2	IPR002404
Domain	MT	DNAH3 DNAH10	3.15e-03	14	113	2	PF12777
Domain	AAA_8	DNAH3 DNAH10	3.15e-03	14	113	2	PF12780
Domain	uDENN	SBF1 SBF2	3.15e-03	14	113	2	SM00800
Domain	AAA_5	DNAH3 DNAH10	3.15e-03	14	113	2	PF07728
Domain	CUB	CSMD3 BMP1 LRP10	3.24e-03	49	113	3	PF00431
Domain	CUB	CSMD3 BMP1 LRP10	3.44e-03	50	113	3	SM00042
Domain	Ig-like_dom	SEMA3C PSG9 UNC5B FCRL6 NCAN CD79B CD200R1L LILRB5 UNC5D	3.49e-03	503	113	9	IPR007110
Domain	DHC_fam	DNAH3 DNAH10	3.62e-03	15	113	2	IPR026983
Domain	uDENN	SBF1 SBF2	3.62e-03	15	113	2	PF03456
Domain	Dynein_heavy	DNAH3 DNAH10	3.62e-03	15	113	2	PF03028
Domain	Lactamase_B	PNKD DCLRE1C	3.62e-03	15	113	2	SM00849
Domain	Dynein_heavy_dom	DNAH3 DNAH10	3.62e-03	15	113	2	IPR004273
Domain	-	CSMD3 BMP1 LRP10	3.84e-03	52	113	3	2.60.120.290
Domain	CUB	CSMD3 BMP1 LRP10	4.05e-03	53	113	3	PS01180
Domain	IG	SEMA3C PSG9 UNC5B FCRL6 NCAN CD79B LILRB5 UNC5D	4.07e-03	421	113	8	SM00409
Domain	Ig_sub	SEMA3C PSG9 UNC5B FCRL6 NCAN CD79B LILRB5 UNC5D	4.07e-03	421	113	8	IPR003599
Domain	GRAM	SBF1 SBF2	4.12e-03	16	113	2	SM00568
Domain	DENN	SBF1 SBF2	4.12e-03	16	113	2	SM00799
Domain	DENN	SBF1 SBF2	4.12e-03	16	113	2	PF02141
Domain	dDENN	SBF1 SBF2	4.12e-03	16	113	2	PF03455
Domain	UDENN	SBF1 SBF2	4.12e-03	16	113	2	PS50946
Domain	DDENN	SBF1 SBF2	4.12e-03	16	113	2	PS50947
Domain	dDENN	SBF1 SBF2	4.12e-03	16	113	2	SM00801
Domain	dDENN_dom	SBF1 SBF2	4.12e-03	16	113	2	IPR005112
Domain	uDENN_dom	SBF1 SBF2	4.12e-03	16	113	2	IPR005113
Domain	DENN	SBF1 SBF2	4.12e-03	16	113	2	PS50211
Domain	DENN_dom	SBF1 SBF2	4.12e-03	16	113	2	IPR001194
Domain	CUB_dom	CSMD3 BMP1 LRP10	4.98e-03	57	113	3	IPR000859
Domain	NA_NEUROTRAN_SYMP_2	SLC6A12 SLC6A13	5.21e-03	18	113	2	PS00754
Domain	Wnt	WNT7A WNT9B	5.80e-03	19	113	2	IPR005817
Domain	SNF	SLC6A12 SLC6A13	5.80e-03	19	113	2	PF00209
Domain	WNT1	WNT7A WNT9B	5.80e-03	19	113	2	PS00246
Domain	Na/ntran_symport	SLC6A12 SLC6A13	5.80e-03	19	113	2	IPR000175
Domain	Fd_Rdtase_FAD-bd	NOS2 NOS3	5.80e-03	19	113	2	IPR017927
Domain	Wnt_CS	WNT7A WNT9B	5.80e-03	19	113	2	IPR018161
Domain	wnt	WNT7A WNT9B	5.80e-03	19	113	2	PF00110
Domain	FAD_FR	NOS2 NOS3	5.80e-03	19	113	2	PS51384
Domain	NA_NEUROTRAN_SYMP_1	SLC6A12 SLC6A13	5.80e-03	19	113	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A12 SLC6A13	5.80e-03	19	113	2	PS50267
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR4 SBF1 SBF2	4.84e-06	10	121	3	9736772
Pubmed	Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.	TET2 ASXL1	1.20e-05	2	121	2	24218140
Pubmed	Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice.	NOS2 NOS3	1.20e-05	2	121	2	18931027
Pubmed	Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.	NOS2 NOS3	1.20e-05	2	121	2	18849972
Pubmed	Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3.	CFH FOXO3	1.20e-05	2	121	2	17558024
Pubmed	Nitric oxide overproduction derived from inducible nitric oxide synthase increases cardiomyocyte apoptosis in human atrial fibrillation.	NOS2 NOS3	1.20e-05	2	121	2	18585800
Pubmed	Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.	APP NOS3	1.20e-05	2	121	2	21127294
Pubmed	Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS.	NOS2 NOS3	1.20e-05	2	121	2	11435211
Pubmed	Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia.	TET2 ASXL1	1.20e-05	2	121	2	26771811
Pubmed	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.	HCRTR1 HCRTR2	1.20e-05	2	121	2	34475397
Pubmed	Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small cell lung cancer patients following the definitive radiochemotherapy.	NOS2 NOS3	1.20e-05	2	121	2	22862164
Pubmed	Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS.	NOS2 NOS3	1.20e-05	2	121	2	17259438
Pubmed	Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) expression in fulminant hepatic failure.	NOS2 NOS3	1.20e-05	2	121	2	12399227
Pubmed	Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells.	NOS2 NOS3	1.20e-05	2	121	2	18453977
Pubmed	G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.	HCRTR1 HCRTR2	1.20e-05	2	121	2	27237973
Pubmed	Impaired lymphatic contraction associated with immunosuppression.	NOS2 NOS3	1.20e-05	2	121	2	22065738
Pubmed	Nitric oxide synthase and postischemic liver injury.	NOS2 NOS3	1.20e-05	2	121	2	11027558
Pubmed	Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.	HCRTR1 HCRTR2	1.20e-05	2	121	2	26950369
Pubmed	Supplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice.	APP NOS3	1.20e-05	2	121	2	22886025
Pubmed	eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia.	NOS2 NOS3	1.20e-05	2	121	2	27030287
Pubmed	Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.	FOXO3 FOXO3B	1.20e-05	2	121	2	9852958
Pubmed	Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.	HCRTR1 HCRTR2	1.20e-05	2	121	2	22389503
Pubmed	Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity.	NOS2 NOS3	1.20e-05	2	121	2	15723985
Pubmed	Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity.	NOS2 NOS3	1.20e-05	2	121	2	16093363
Pubmed	Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations.	TET2 ASXL1	1.20e-05	2	121	2	20334914
Pubmed	Nitric oxide, a key signaling molecule in the murine early embryonic heart.	NOS2 NOS3	1.20e-05	2	121	2	15132985
Pubmed	Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 diabetes mellitus and diabetic nephropathy in the Chinese Han population.	NOS2 NOS3	1.20e-05	2	121	2	27192959
Pubmed	Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.	HCRTR1 HCRTR2	1.20e-05	2	121	2	24485472
Pubmed	Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain.	NOS2 NOS3	1.20e-05	2	121	2	15226517
Pubmed	Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation.	NOS2 NOS3	1.20e-05	2	121	2	18753139
Pubmed	Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.	ANKS1B APP	1.20e-05	2	121	2	15347684
Pubmed	Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.	NOS2 NOS3	1.20e-05	2	121	2	7479866
Pubmed	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.	FOXO3 TET2	1.20e-05	2	121	2	28660881
Pubmed	The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis.	NOS2 NOS3	1.20e-05	2	121	2	16889995
Pubmed	Analysis of core mutation and TET2/ASXL1 mutations DNA methylation profile in myelodysplastic syndrome.	TET2 ASXL1	1.20e-05	2	121	2	37288803
Pubmed	Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.	NOS2 NOS3	1.20e-05	2	121	2	12437348
Pubmed	The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice.	NOS2 NOS3	1.20e-05	2	121	2	15547116
Pubmed	Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies.	NOS2 NOS3	1.20e-05	2	121	2	11297817
Pubmed	Elevated blood pressures in mice lacking endothelial nitric oxide synthase.	NOS2 NOS3	1.20e-05	2	121	2	8917564
Pubmed	Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism.	NOS2 NOS3	1.20e-05	2	121	2	18274157
Pubmed	Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.	NOS2 NOS3	1.20e-05	2	121	2	10981965
Pubmed	Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".	HCRTR1 HCRTR2	1.20e-05	2	121	2	26582896
Pubmed	Nitric oxide synthase in healthy and inflamed human dental pulp.	NOS2 NOS3	1.20e-05	2	121	2	15044505
Pubmed	Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease.	NOS2 NOS3	1.20e-05	2	121	2	19912632
Pubmed	Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways.	NOS2 NOS3	1.20e-05	2	121	2	27665476
Pubmed	Serum inducible and endothelial nitric oxide synthase in coronary artery disease patients with Type 2 Diabetes mellitus.	NOS2 NOS3	1.20e-05	2	121	2	35647851
Pubmed	Nitric oxide synthases modulate progenitor and resident endothelial cell behavior in galactosemia.	NOS2 NOS3	1.20e-05	2	121	2	16356104
Pubmed	Participation of the mouse implanting trophoblast in nitric oxide production during pregnancy.	NOS2 NOS3	1.20e-05	2	121	2	10642561
Pubmed	Antisense evidence for two functionally active forms of nitric oxide synthase in brain microvascular endothelium.	NOS2 NOS3	1.20e-05	2	121	2	8702423
Pubmed	Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children.	NOS2 NOS3	1.20e-05	2	121	2	12631094
Pubmed	The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice.	NOS2 NOS3	1.20e-05	2	121	2	12730888
Pubmed	Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure.	NOS2 NOS3	1.20e-05	2	121	2	25892862
Pubmed	Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.	HCRTR1 HCRTR2	1.20e-05	2	121	2	26447462
Pubmed	Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.	NOS2 NOS3	1.20e-05	2	121	2	22000010
Pubmed	Inducible and endothelial nitric oxide synthase genes polymorphism in inflammatory bowel disease.	NOS2 NOS3	1.20e-05	2	121	2	16634870
Pubmed	Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension.	NOS2 NOS3	1.20e-05	2	121	2	12381520
Pubmed	Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons.	HCRTR1 HCRTR2	1.20e-05	2	121	2	20576035
Pubmed	Is apoptosis the cause of noninsertional achilles tendinopathy?	NOS2 NOS3	1.20e-05	2	121	2	19741110
Pubmed	Reduced expression of endothelial and inducible nitric oxide synthase in a multidrug resistant variant of the MCF-7 human breast cancer cell line.	NOS2 NOS3	1.20e-05	2	121	2	15492785
Pubmed	Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination.	SBF1 SBF2	1.20e-05	2	121	2	34718573
Pubmed	The excellent outcomes of ABO-incompatible kidney transplantation with high titer (>×2048) using anti-CD20 and anti-CD25 antibody without splenectomy: two case reports.	MS4A1 IL2RA	1.20e-05	2	121	2	21839272
Pubmed	Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice.	NOS2 NOS3	1.20e-05	2	121	2	21154234
Pubmed	Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.	HCRTR1 HCRTR2	1.20e-05	2	121	2	34126185
Pubmed	The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.	APP NOS2	1.20e-05	2	121	2	19096157
Pubmed	Dissociation between adipose nitric oxide synthase expression and tissue metabolism.	NOS2 NOS3	1.20e-05	2	121	2	17456572
Pubmed	Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.	NOS2 NOS3	1.20e-05	2	121	2	25878398
Pubmed	TET2 rs2454206, TET2 rs12498609 and ASXL1 rs3746609 single nucleotide polymorphisms in patients with myelodysplastic syndromes.	TET2 ASXL1	1.20e-05	2	121	2	30454965
Pubmed	Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS.	NOS2 NOS3	1.20e-05	2	121	2	33404076
Pubmed	Nitric oxide synthase and tyrosine nitration in idiopathic asthenozoospermia: an immunohistochemical study.	NOS2 NOS3	1.20e-05	2	121	2	22244784
Pubmed	Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms.	HCRTR1 HCRTR2	1.20e-05	2	121	2	27988352
Pubmed	Deficiency of inducible and endothelial nitric oxide synthase results in diminished bone formation and delayed union and nonunion development.	NOS2 NOS3	1.20e-05	2	121	2	26555548
Pubmed	[Immunohistochemical study on expression of iNOS and eNOS during skin incised wound healing in mice].	NOS2 NOS3	1.20e-05	2	121	2	16259358
Pubmed	Role of nitric oxide synthase genes in hepatitis E virus infection.	NOS2 NOS3	1.20e-05	2	121	2	24215170
Pubmed	Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II.	NOS2 NOS3	1.20e-05	2	121	2	11880293
Pubmed	[Effects of osmolarity on NO synthase activity in endothelial cells and its mechanism].	NOS2 NOS3	1.20e-05	2	121	2	21171409
Pubmed	Long-term survival after ischemic stroke in postmenopausal women is affected by an interaction between smoking and genetic variation in nitric oxide synthases.	NOS2 NOS3	1.20e-05	2	121	2	18648197
Pubmed	Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.	HCRTR1 HCRTR2	1.20e-05	2	121	2	21510948
Pubmed	Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs.	NOS2 NOS3	1.20e-05	2	121	2	26799210
Pubmed	Structural basis for endothelial nitric oxide synthase binding to calmodulin.	NOS2 NOS3	1.20e-05	2	121	2	12574113
Pubmed	Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice.	NOS2 NOS3	1.20e-05	2	121	2	25680465
Pubmed	Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.	FOXO3 FOXO3B	1.20e-05	2	121	2	22588664
Pubmed	Endogenous endothelial nitric oxide synthase-derived nitric oxide is a physiological regulator of myocardial oxygen consumption.	NOS2 NOS3	1.20e-05	2	121	2	10205152
Pubmed	Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney.	NOS2 NOS3	1.20e-05	2	121	2	12682064
Pubmed	Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.	HCRTR1 HCRTR2	1.20e-05	2	121	2	11723285
Pubmed	Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction.	NOS2 NOS3	1.20e-05	2	121	2	16631534
Pubmed	Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels.	NOS2 NOS3	1.20e-05	2	121	2	23420659
Pubmed	Expression of nitric oxide synthases in parathyroid gland adenoma and parathyroid gland hyperplasia.	NOS2 NOS3	1.20e-05	2	121	2	16136006
Pubmed	[Polymorphism of eNOS and iNOS Genes and Chronic Heart Failure in Patients With Ischemic Heart Disease].	NOS2 NOS3	1.20e-05	2	121	2	20459417
Pubmed	Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction.	NOS2 NOS3	1.20e-05	2	121	2	18828052
Pubmed	The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.	ANKS1B APP	1.20e-05	2	121	2	15004329
Pubmed	Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.	NOS2 NOS3	1.20e-05	2	121	2	10074942
Pubmed	Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS.	NOS2 NOS3	1.20e-05	2	121	2	16326029
Pubmed	Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.	NOS2 NOS3	1.20e-05	2	121	2	17099710
Pubmed	LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.	APP LRP10	1.20e-05	2	121	2	22734645
Pubmed	Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's disease.	NOS2 NOS3	1.20e-05	2	121	2	20074466
Pubmed	[The relationship between resting heart rate and single nucleotide polymorphism at 3 sites of nitric oxide synthase gene in the Chinese Han nationality population].	NOS2 NOS3	1.20e-05	2	121	2	17160951
Pubmed	Expressions and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy.	NOS2 NOS3	1.20e-05	2	121	2	15970571
Pubmed	Role of nitric oxide synthases in elastase-induced emphysema.	NOS2 NOS3	1.20e-05	2	121	2	20956973
Pubmed	Cellular localization of orexin receptors in human pituitary.	HCRTR1 HCRTR2	1.20e-05	2	121	2	11443222
Pubmed	iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.	NOS2 NOS3	1.20e-05	2	121	2	26586908
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH PAPPA2 CR1L CSMD3 SVEP1 NCAN IL2RA	1.96e-09	57	69	7	1179
GeneFamily	Hypocretin receptors	HCRTR1 HCRTR2	1.44e-05	2	69	2	228
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR4 SBF1 SBF2	2.34e-05	15	69	3	903
GeneFamily	Dyneins, axonemal	DNAH3 DNAH10	1.88e-03	17	69	2	536
GeneFamily	Wnt family\|Endogenous ligands	WNT7A WNT9B	2.35e-03	19	69	2	360
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	SBF1 SBF2	4.07e-03	25	69	2	504
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 DNAH3 KIF27 ADGRB2 PHF7 AK9 LRRIQ1	2.49e-07	157	121	7	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A12 SLC6A13 ARSF D2HGDH	7.27e-07	184	121	7	9434731f651820b05335085582960f08fbf895de
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A12 SLC6A13 ARSF D2HGDH	7.82e-07	186	121	7	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 DNAH3 KIF27 DNAH10 ABCA13 AK9 LRRIQ1	1.04e-06	194	121	7	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	UNC5B NCKAP5 SVEP1 GREB1L ARSF CD79B HCRTR2	1.27e-06	200	121	7	c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	UNC5B NCKAP5 SVEP1 GREB1L ARSF CD79B HCRTR2	1.27e-06	200	121	7	ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCell	356C-Myeloid-Dendritic-cDC1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CLEC6A NCKAP5 FCRL6 ADM5 CTRL CD200R1L	6.24e-06	166	121	6	971ee6602a1e751f453f9d823295e63dadce62bf
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH FMO3 APP CA10 CCDC140 UNC5D	9.00e-06	177	121	6	9e65b39fd797b6ce204b6480415810d1923acee5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A12 SLC6A13 ARSF	9.00e-06	177	121	6	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|343B / Donor, Lineage, Cell class and subclass (all cells)	POM121C CSMD3 STK35 MTMR4 SBF2 PEAK1	9.29e-06	178	121	6	ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 WNT9B ANKS1B GRID2 ARSF UNC5D	1.02e-05	181	121	6	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A12 SLC6A13 ARSF	1.09e-05	183	121	6	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A13 ARSF COBL	1.19e-05	186	121	6	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	UNC5B SVEP1 GREB1L ARSF CD79B HCRTR2	1.27e-05	188	121	6	ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCell	Epithelial-D_(Ciliated)\|World / shred on cell class and cell subclass (v4)	DNAH3 KIF27 DNAH10 PORCN AK9 LRRIQ1	1.31e-05	189	121	6	0bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCell	PND01-Epithelial-Epithelial_Airway\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 DNAH10 AK9 CCKAR LRRIQ1	1.31e-05	189	121	6	38cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 DNAH3 DNAH10 ABCA13 AK9 LRRIQ1	1.31e-05	189	121	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 SEMA3C FMO3 SVEP1 URB1 PEAK1	1.35e-05	190	121	6	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 SEMA3C FMO3 SVEP1 URB1 PEAK1	1.35e-05	190	121	6	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 DNAH3 DNAH10 ABCA13 AK9 LRRIQ1	1.47e-05	193	121	6	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 DNAH3 KIF27 DNAH10 AK9 LRRIQ1	1.65e-05	197	121	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Biopsy_Control_(H.)-Epithelial-Differentiating_Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFAP47 DNAH3 DNAH10 ABCA13 ADGRB2 LRRIQ1	1.80e-05	200	121	6	a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCell	COVID-19-kidney-Epithelial_Doublet\|kidney / Disease (COVID-19 only), tissue and cell type	GRID2 CSMD3 IZUMO1R SPATA31A6 MS4A1	2.26e-05	124	121	5	d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic-3\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	NLRP11 KLK3 CA10 CCKAR HCRTR2	2.53e-05	127	121	5	df2854bcb2708ddc13b3ca48c03887380e827790
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 CLEC6A IRF4 CD200R1L LILRB5	5.44e-05	149	121	5	a464c0fd54e3c9e1d40d95b49489cb9371dd7c24
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	5.79e-05	151	121	5	8216462e723fec2797387929dde095370947e10a
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	UNC5B ADGRB2 FCRL6 SVEP1 COBL	6.36e-05	154	121	5	ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFH SLC6A12 SLC6A13 TAGLN2 IL2RA	6.55e-05	155	121	5	ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFH SLC6A12 SLC6A13 TAGLN2 IL2RA	6.55e-05	155	121	5	0f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell-Peri\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFH SLC6A12 SLC6A13 TAGLN2 IL2RA	6.55e-05	155	121	5	d8b5145258f075b15080f8739f537f48dd22225e
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CLEC6A ADM5 CPT1C HELZ2 COBL	6.96e-05	157	121	5	4183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CLEC6A ADM5 CPT1C HELZ2 COBL	7.18e-05	158	121	5	de65af8d3b8514b17978155f31975e2347b75251
ToppCell	ASK440-Immune-B_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	ANKS1B MS4A1 CD79B MOCS1 SEC14L1	7.39e-05	159	121	5	d31eb59c1b5948df721b829b9a7e806f27cbd41c
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 TET2 TECPR2 HSD11B1 IL2RA	7.62e-05	160	121	5	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DNAH10 ABCA13 ANKS1B CSMD3 UNC5D	8.08e-05	162	121	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ST7 WNT7A CR1L MS4A1 KIF3C	8.81e-05	165	121	5	ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS1B IRF4 MS4A1 CD79B HCRTR2	9.32e-05	167	121	5	3c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS1B IRF4 MS4A1 CD79B HCRTR2	9.32e-05	167	121	5	77a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS1B IRF4 MS4A1 CD79B HCRTR2	9.59e-05	168	121	5	ce9fae8b295c668b0959d5007a8bcd401d80e258
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 DNAH10 AK9 LRRIQ1	9.59e-05	168	121	5	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 DNAH10 AK9 LRRIQ1	9.59e-05	168	121	5	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3C PSG9 ARSF ADAMTS18 CD79B	9.86e-05	169	121	5	d161dd8eb22633392b6c6466ee9eff4042464149
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 DNAH3 DNAH10 AK9 LRRIQ1	9.86e-05	169	121	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 DNAH10 ABCA13 AK9 LRRIQ1	9.86e-05	169	121	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	NS-critical-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CUL1 LETMD1 URB1 MS4A1 HELZ2	1.04e-04	171	121	5	bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH FMO3 SLC6A12 SLC6A13 ADAMTS18	1.04e-04	171	121	5	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS1B IRF4 MS4A1 CD79B HCRTR2	1.04e-04	171	121	5	584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCell	facs-Heart-LV-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 IRF4 MS4A1 ADAMTS18 CD79B	1.04e-04	171	121	5	c6fc9ef9735dbf5314a4c7dac2b2954b0985ae4d
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3C IRF4 SVEP1 MS4A1 CD79B	1.04e-04	171	121	5	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	facs-Heart-LV-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 IRF4 MS4A1 ADAMTS18 CD79B	1.04e-04	171	121	5	55b194a9bf4d3e4b5d96e0d1298424359c441cbb
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP47 KIF27 CCKAR LRRIQ1 NCAN	1.04e-04	171	121	5	4f2a83d8091f1fd29542d2e5add57fd482e921b5
ToppCell	356C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NCKAP5 FCRL6 ADM5 CTRL CD200R1L	1.04e-04	171	121	5	3d60e7ecf25e4b781ba2387671b2aad247fb75ff
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	TET2 HDX IRF4 BMP1 IL2RA	1.10e-04	173	121	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOP2 IRF4 MS4A1 CD79B HCRTR2	1.13e-04	174	121	5	8bdf5a97faf1cf0426d1a8851f8a3e27578f7598
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOP2 IRF4 MS4A1 CD79B HCRTR2	1.13e-04	174	121	5	fbf998dd33ac27dad7639ea85fca393ba2835307
ToppCell	mild-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KCTD19 IRF4 APP RTKN COBL	1.19e-04	176	121	5	59a9c262c252b7d220a025837922d98e9d6b0a24
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B AQP7B NCKAP5 SLC6A13 ARSF	1.19e-04	176	121	5	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS1B IRF4 MS4A1 CD79B HCRTR2	1.26e-04	178	121	5	9b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH SLC6A12 SLC6A13 HELZ2 TAGLN2	1.29e-04	179	121	5	368f7e91e9c2c854c8778788cead022d158d1122
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	DOK1 FBXL18 MS4A1 TECPR2 EIF4G3	1.29e-04	179	121	5	5be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH SLC6A12 SLC6A13 HELZ2 TAGLN2	1.29e-04	179	121	5	11e434fc49bc0a806197f21debcac8337e0502aa
ToppCell	mild-Myeloid-pDC\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KCTD19 IRF4 APP KCTD5 COBL	1.32e-04	180	121	5	38614155fa537d0defda914c531c697be0ef06d8
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DNAH3 SEMA3C NCKAP5 ARSF HCRTR1	1.32e-04	180	121	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 WNT9B GALNT17 TECPR2 KIF3C	1.36e-04	181	121	5	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 SEMA3C CSMD3 GALNT17 ADAMTS18	1.36e-04	181	121	5	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	POM121C CSMD3 STK35 MTMR4 PEAK1	1.39e-04	182	121	5	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.39e-04	182	121	5	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	DOK4 HELZ2 NOS2 NOS3 GARRE1	1.39e-04	182	121	5	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PKD1L1 HDX ANKS1B HSD11B1 IL2RA	1.43e-04	183	121	5	f142b320023eef00b48d4820c46214c9794d37e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH FMO3 SLC6A12 HELZ2 TAGLN2	1.47e-04	184	121	5	9f524f0a1e7eb50e3b97a35c0ea7e183a4e99aa8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 ABCA13 CSMD3 ASXL3 UNC5D	1.47e-04	184	121	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	(1)_T_cells-(1)_T_regulatory\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ANKS1B IRF4 CD79B IL2RA SEC14L1	1.47e-04	184	121	5	3cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 ABCA13 CSMD3 ASXL3 UNC5D	1.47e-04	184	121	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 ABCA13 CSMD3 ASXL3 UNC5D	1.47e-04	184	121	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH FMO3 SLC6A12 HELZ2 TAGLN2	1.47e-04	184	121	5	779016341dbd6d54b5fdb8711692d31a9b2cec4b
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.47e-04	184	121	5	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	SEMA3C KCTD19 IRF4 APP COBL	1.47e-04	184	121	5	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.51e-04	185	121	5	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	Ciliated_cells-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.54e-04	186	121	5	f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCell	Control-Lymphoid-Tregs\|Control / Condition, Lineage and Cell class	ADGRB2 ANKS1B IRF4 CD79B IL2RA	1.54e-04	186	121	5	6144f32a370594e45b91da142b4f435370c69b9a
ToppCell	COPD-Epithelial-Ciliated\|COPD / Disease state, Lineage and Cell class	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.58e-04	187	121	5	f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	ASXL1 SEMA3C CSMD3 GALNT17 ADAMTS18	1.58e-04	187	121	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.62e-04	188	121	5	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	DNAH3 KIF27 DNAH10 AK9 LRRIQ1	1.62e-04	188	121	5	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	droplet-Marrow-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP SLC6A12 SLC6A13 TAGLN2 HSD11B1	1.62e-04	188	121	5	1526e271411e381eae7a342003002276f83f47a3
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.62e-04	188	121	5	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.62e-04	188	121	5	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WNT9B APP NOS3 GARRE1 SEC14L1	1.66e-04	189	121	5	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 AK9 LRRIQ1 NOS2	1.66e-04	189	121	5	b55de812043b670cbde810d7d42f45909b6d66ef
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.66e-04	189	121	5	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.66e-04	189	121	5	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	Control-Epithelial-Ciliated\|Control / Disease state, Lineage and Cell class	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.66e-04	189	121	5	c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.66e-04	189	121	5	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.66e-04	189	121	5	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 AK9 LRRIQ1 NOS2	1.66e-04	189	121	5	4e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCell	cellseq2-Epithelial-Epithelial_Airway\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.70e-04	190	121	5	17829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell	E18.5-Epithelial-Epithelial_Airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH3 KIF27 AK9 CCKAR LRRIQ1	1.70e-04	190	121	5	5c012935ea5e35a2d0d08ea7dc04ffbe3c2a10ac
ToppCell	COVID-19_Moderate-pDC\|World / disease group, cell group and cell class	KCTD19 IRF4 APP KCTD5 COBL	1.75e-04	191	121	5	93adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 SEMA3C CA10 GREB1L LRRIQ1	1.75e-04	191	121	5	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	CFAP47 DNAH3 DNAH10 ABCA13 LRRIQ1	1.75e-04	191	121	5	ea1d2c6838119b7019e9a2ff71d6212262b51b57
Drug	sapropterin	APP NOS2 NOS3	1.51e-05	10	116	3	ctd:C003402
Drug	N,N-dimethylarginine	NOS2 NOS3	2.57e-05	2	116	2	DB01686
Drug	6 Ni	NOS2 NOS3	2.57e-05	2	116	2	CID000024239
Drug	3 h x	NOS2 NOS3	2.57e-05	2	116	2	CID016058621
Drug	DB02077	NOS2 NOS3	2.57e-05	2	116	2	CID000656912
Drug	AC1LCVOW	NOS2 NOS3	2.57e-05	2	116	2	CID000656910
Drug	5-nitroindazole	NOS2 NOS3	2.57e-05	2	116	2	CID000021501
Drug	AC1NRAON	NOS2 NOS3	2.57e-05	2	116	2	CID005288020
Drug	DB07388	NOS2 NOS3	2.57e-05	2	116	2	CID011149707
Drug	AC1L96OZ	NOS2 NOS3	2.57e-05	2	116	2	CID000439092
Drug	AC1NRAUH	NOS2 NOS3	2.57e-05	2	116	2	CID005288100
Drug	ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE	NOS2 NOS3	2.57e-05	2	116	2	DB07388
Drug	NSC-10379	NOS2 NOS3	2.57e-05	2	116	2	CID000223131
Drug	hard metal	NOS2 NOS3	2.57e-05	2	116	2	ctd:C080121
Drug	Ethylisothiourea	NOS2 NOS3	2.57e-05	2	116	2	DB02234
Drug	7-Nitroindazole	NOS2 NOS3	2.57e-05	2	116	2	DB02207
Drug	5-Nitroindazole	NOS2 NOS3	2.57e-05	2	116	2	DB04534
Drug	6-Nitroindazole	NOS2 NOS3	2.57e-05	2	116	2	DB03100
Drug	scutellarin	APP NOS2 NOS3	3.55e-05	13	116	3	ctd:C484876
Drug	tetrahydrocurcumin	APP NOS2 NOS3	3.55e-05	13	116	3	ctd:C096277
Drug	3-(2-hydroxyphenyl)prop-2-enal	CTRL IL2RA NOS2	5.61e-05	15	116	3	CID000098373
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; MCF7; HT_HG-U133A	UNC5B PHF7 IRF4 SVEP1 CCKAR CD79B HCRTR2	6.87e-05	197	116	7	4730_UP
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	THEMIS2 DOK1 SVEP1 SBF1 MS4A1 DOK4 MOCS1	7.09e-05	198	116	7	6525_UP
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 DOK1 GREB1L BMP1 DOK4 CTRL MOCS1	7.09e-05	198	116	7	5972_DN
Drug	Monobenzone [103-16-2]; Up 200; 20uM; PC3; HT_HG-U133A	FBXO11 KLK3 SVEP1 URB1 GAN CD79B HCRTR1	7.32e-05	199	116	7	6713_UP
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	UNC5B IRF4 CA10 MS4A1 DOK4 CTRL MOCS1	7.55e-05	200	116	7	6032_UP
Drug	martentoxin, Buthus martensi	NOS2 NOS3	7.69e-05	3	116	2	ctd:C471035
Drug	NCX 6560	NOS2 NOS3	7.69e-05	3	116	2	ctd:C524539
Drug	3-Bromo-7-Nitroindazole	NOS2 NOS3	7.69e-05	3	116	2	DB01997
Drug	camostat	CCKAR NOS3	7.69e-05	3	116	2	ctd:C034532
Drug	r142	NOS2 NOS3	7.69e-05	3	116	2	CID002734672
Drug	N-(3-(Aminomethyl)Benzyl)Acetamidine	NOS2 NOS3	7.69e-05	3	116	2	DB02044
Drug	1-TRIM	PSG9 NOS2 NOS3	9.94e-05	18	116	3	CID000001359
Disease	dermoid cyst of ovary (implicated_via_orthology)	FOXO3 FOXO3B	1.53e-05	2	116	2	DOID:5117 (implicated_via_orthology)
Disease	tubulin polymerization-promoting protein family member 2 measurement	CFH KCTD19	4.58e-05	3	116	2	EFO_0802164
Disease	Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease	TET2 ASXL1	9.15e-05	4	116	2	C1301365
Disease	Alzheimer disease type 1	APP NOS3	9.15e-05	4	116	2	cv:C1863052
Disease	ALZHEIMER DISEASE, FAMILIAL, 1	APP NOS3	9.15e-05	4	116	2	104300
Disease	pulmonary edema (biomarker_via_orthology)	NOS2 NOS3	9.15e-05	4	116	2	DOID:11396 (biomarker_via_orthology)
Disease	diabetic angiopathy (biomarker_via_orthology)	NOS2 NOS3	9.15e-05	4	116	2	DOID:11713 (biomarker_via_orthology)
Disease	Fc receptor-like protein 6 measurement	CFH FCRL6	9.15e-05	4	116	2	EFO_0801600
Disease	renal hypertension (implicated_via_orthology)	NOS2 NOS3	1.52e-04	5	116	2	DOID:1073 (implicated_via_orthology)
Disease	Myelodysplastic syndrome	TET2 ASXL1	1.52e-04	5	116	2	cv:C3463824
Disease	chronic lymphocytic leukemia (is_implicated_in)	IRF4 CD79B	1.52e-04	5	116	2	DOID:1040 (is_implicated_in)
Disease	MYELODYSPLASTIC SYNDROME	TET2 ASXL1	1.52e-04	5	116	2	614286
Disease	chronic myelomonocytic leukemia (is_implicated_in)	TET2 ASXL1	1.52e-04	5	116	2	DOID:0080188 (is_implicated_in)
Disease	1-myristoyl-2-docosahexaenoyl-GPC (14:0/22:6) measurement	GREB1L MIB1	1.52e-04	5	116	2	EFO_0800454
Disease	cell surface glycoprotein CD200 receptor 1 measurement	CFH CD200R1L	2.27e-04	6	116	2	EFO_0020253
Disease	Chronic Obstructive Airway Disease	FOXO3 NOS2 NOS3	2.96e-04	33	116	3	C0024117
Disease	Chronic Airflow Obstruction	FOXO3 NOS2 NOS3	2.96e-04	33	116	3	C1527303
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD8	3.18e-04	7	116	2	DOID:0050834 (implicated_via_orthology)
Disease	Early-onset autosomal dominant Alzheimer disease	APP NOS3	3.18e-04	7	116	2	cv:CN043596
Disease	neuroticism measurement, cognitive function measurement	FOXO3 TET2 ASXL1 KIF27 TMEM219 ANKS1B SCAF1 ASXL3 EIF4G3	4.09e-04	566	116	9	EFO_0007660, EFO_0008354
Disease	Alzheimer disease	APP NOS3	4.22e-04	8	116	2	cv:C0002395
Disease	Subarachnoid Hemorrhage, Aneurysmal	UNC5B NOS2	4.22e-04	8	116	2	C0751530
Disease	Subarachnoid Hemorrhage, Spontaneous	UNC5B NOS2	4.22e-04	8	116	2	C0472383
Disease	Subarachnoid Hemorrhage, Intracranial	UNC5B NOS2	4.22e-04	8	116	2	C0795688
Disease	Perinatal Subarachnoid Hemorrhage	UNC5B NOS2	4.22e-04	8	116	2	C0270192
Disease	epilepsy (implicated_via_orthology)	SBF1 SBF2 MIB1 NOS2 NOS3	4.74e-04	163	116	5	DOID:1826 (implicated_via_orthology)
Disease	dentate gyrus volume measurement	FOXO3 TMEM219 PKD1L1	4.88e-04	39	116	3	EFO_0010083
Disease	Neoplasm Recurrence, Local	TET2 ASXL1 KLK3	4.88e-04	39	116	3	C0027643
Disease	Hepatic Insufficiency	NOS2 NOS3	5.42e-04	9	116	2	C1306571
Disease	Subarachnoid Hemorrhage	UNC5B NOS2	5.42e-04	9	116	2	C0038525
Disease	serum albumin measurement	CFH SEMA3C IRF4 HBP1 SVEP1 SCAF1 CPT1C SBF2 LILRB5	5.64e-04	592	116	9	EFO_0004535
Disease	hippocampal CA4 volume	FOXO3 TMEM219 PKD1L1	5.66e-04	41	116	3	EFO_0009396
Disease	Streptozotocin Diabetes	FOXO3 HSD11B1 NOS2 NOS3	8.87e-04	108	116	4	C0038433
Disease	Diabetes Mellitus, Experimental	FOXO3 HSD11B1 NOS2 NOS3	8.87e-04	108	116	4	C0011853
Disease	Alloxan Diabetes	FOXO3 HSD11B1 NOS2 NOS3	8.87e-04	108	116	4	C0002152
Disease	Essential Hypertension	NOS2 NOS3	9.86e-04	12	116	2	C0085580
Disease	Charcot-Marie-Tooth disease type 4	SBF1 SBF2	1.16e-03	13	116	2	cv:C4082197
Disease	superior frontal gyrus grey matter volume measurement	CCKAR EIF4G3	1.35e-03	14	116	2	EFO_0006516
Disease	hypertension (is_implicated_in)	FMO3 HSD11B1 NOS2 NOS3	1.35e-03	121	116	4	DOID:10763 (is_implicated_in)
Disease	amino acid measurement	PNKD CA10 SLC6A12 SLC6A13 COBL GAN CD79B KIF3C UNC5D	1.46e-03	678	116	9	EFO_0005134
Disease	myelodysplastic syndrome (implicated_via_orthology)	TET2 ASXL1	1.56e-03	15	116	2	DOID:0050908 (implicated_via_orthology)
Disease	Sarcomatoid Renal Cell Carcinoma	TET2 PNKD CSMD3 TAGLN2	1.66e-03	128	116	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	TET2 PNKD CSMD3 TAGLN2	1.66e-03	128	116	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	TET2 PNKD CSMD3 TAGLN2	1.66e-03	128	116	4	C1266044
Disease	Papillary Renal Cell Carcinoma	TET2 PNKD CSMD3 TAGLN2	1.66e-03	128	116	4	C1306837
Disease	Renal Cell Carcinoma	TET2 PNKD CSMD3 TAGLN2	1.66e-03	128	116	4	C0007134
Disease	Colorectal Carcinoma	TET2 DNAH3 ABCA13 OTOP2 GRID2 CSMD3 NCDN ADAMTS18 MCRS1	1.85e-03	702	116	9	C0009402
Disease	Necrotizing Enterocolitis	NOS2 NOS3	2.00e-03	17	116	2	C0520459
Disease	smoking status measurement	FOXO3 SAMD8 ADGRB2 ANKS1B FBXO11 GRID2 CA10 GALNT17 MCRS1 EIF4G3 ADAT1 PCK2	2.07e-03	1160	116	12	EFO_0006527
Disease	eosinophil count	THEMIS2 TET2 DNAH3 KIF27 IRF4 PNKD SVEP1 SBF2 HELZ2 PEAK1 EIF4G3 IL2RA NOS2 D2HGDH	2.13e-03	1488	116	14	EFO_0004842
Disease	Gastric ulcer	NOS2 NOS3	2.25e-03	18	116	2	C0038358
Disease	essential hypertension (is_implicated_in)	HSD11B1 NOS3	2.25e-03	18	116	2	DOID:10825 (is_implicated_in)
Disease	familial hyperlipidemia (biomarker_via_orthology)	HSD11B1 NOS3	2.51e-03	19	116	2	DOID:1168 (biomarker_via_orthology)
Disease	Omenn Syndrome	DCLRE1C IL2RA	2.51e-03	19	116	2	C2700553
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TET2 PNKD CSMD3 TAGLN2	2.82e-03	148	116	4	C0279702
Disease	diffuse plaque measurement	SEMA3C ABCA13 ANKS1B FBXO11 IRF4 CSMD3 SCAF1 ADAMTS18 HCRTR2	3.08e-03	758	116	9	EFO_0010699
Disease	Mental Depression	APP HSD11B1 NOS2 NOS3 HCRTR1	3.36e-03	254	116	5	C0011570
Disease	complement factor H-like 1 protein measurement	CFH KLK3	3.36e-03	22	116	2	EFO_0600092
Disease	impotence (biomarker_via_orthology)	NOS2 NOS3	3.36e-03	22	116	2	DOID:1875 (biomarker_via_orthology)
Disease	vitronectin measurement	CFH NOS2	3.67e-03	23	116	2	EFO_0021843

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRSRKCSVAGPAWAT	ADGRB2	441	O60241
QLSELNQGRTWLKPC	ARSF	551	P54793
IVSWGTKNCNVRAPA	CTRL	231	P40313
LVCQAVLSGKWPSSR	CHD8	2166	Q9HCK8
LAQCPARWVTSGTAR	ADM5	101	C9JUS6
RVCRSDNTWTGKVPI	CSMD3	3451	Q7Z407
PVTIQNWCKRGRKQC	APP	91	P05067
ADLNPRQKNSSCWRT	ABCA13	4296	Q86UQ4
GNKRITCRNGQWSEP	CFH	1146	P08603
GAICKPLQSRVWQTK	CCKAR	141	P32238
SLWTTLLIRNPCRKI	HSD11B1	261	P28845
WKRTCSRPKSNIVLL	MS4A1	216	P11836
RPSKVCIWRIQVSEG	BMP1	456	P13497
SKRNRWRRQSCQGPS	CCDC140	56	Q96MF4
RNPKGSACSRIWQSP	CD79B	36	P40259
APQSWVSRVCAVRQK	ASXL1	1061	Q8IXJ9
RLSWPQSTGICSNIK	ASXL3	2066	Q9C0F0
GRCPKNSRLQWVASS	ADAMTS18	1046	Q8TE60
STLRKQVFGSWIRNP	ADAT1	481	Q9BUB4
QHVKNWLGTCRLPLT	KCTD19	326	Q17RG1
SNLLSIWRGPNVNCT	ANKS1B	41	Q7Z6G8
LIFATKQAWRNAPRC	NOS2	186	P35228
KQAWRNAPRCIGRIQ	NOS2	191	P35228
RIKSQTIACRSGPTW	NAXE	21	Q8NCW5
SRWAAQVIKGTCTLP	FMO3	386	P31513
NLTVPWITGCSRKRA	HDX	421	Q7Z353
RTSPANCTWLILGSK	LRP10	51	Q7Z4F1
ARILGSKLSSWQRNP	NCDN	266	Q9UBB6
RWRLTDLCTKIQRGT	LETMD1	211	Q6P1Q0
PTWKTRLRCALNKSN	IRF4	91	Q15306
ASPERRNSGRCLQKW	IZUMO1R	196	A6ND01
PVVCWKNSRSGTLLL	SBF2	1181	Q86WG5
CWFLISSRPTRGNNV	NLRP11	271	P59045
VTFTNCALGRVPWRK	AQP7B	101	A0A075B734
TLRCQGWKNTPLSQV	FCRL6	36	Q6DN72
RPSTSKVRKSRSWCQ	KIF3C	751	O14782
KVRKSRSWCQSPQRP	KIF3C	756	O14782
TWEIILRGQPSCTKA	CD200R1L	66	Q6Q8B3
ASLSCIRKNSKPWQG	GRID2	351	O43424
KSGTRCRSRSWIQKP	KIF27	656	Q86VH2
WPSCRSIQTLRVLSG	PCK2	21	Q16822
WNTIPLRNKSLQRIC	PEAK1	291	Q9H792
IGSLKDNRPQGWCLS	MED23	1031	Q9ULK4
ASVIARGKPVTLWCQ	LILRB5	36	O75023
RSSQGVLSKGPLICW	GREB1L	221	Q9C091
TCSESWLQVKLRRTP	OOSP4A	26	A0A2R8YFL7
IWSGNQTLETRDCKP	ERVK-7	1111	P63135
ILRCGPWDTLQQVTT	LRRIQ1	786	Q96JM4
FSSQVATLWKGCRVP	MOCS1	416	Q9NZB8
RTCSVWALLRAGNKN	MTMR4	526	Q9NYA4
DTCRQQPIIGIRWKC	MIB1	86	Q86YT6
NRFPVVCWRSGRSKA	SBF1	1191	O95248
APRCVGRIQWGKLQV	NOS3	181	P29474
VSTPRSQWRRQCLKD	OTOP2	481	Q7RTS6
STRGISQLWKRNGPS	POM121C	396	A8CG34
QGRPLSCRWLQKVAR	PORCN	181	Q9H237
QIPGTTSALVRNWKR	HCRTR1	246	O43613
IFRKLWCRQIPGTSS	HCRTR2	246	O43614
WCRQIPGTSSVVQRK	HCRTR2	251	O43614
PVKVQSIVCTGRRQW	PAPPA2	1706	Q9BXP8
PRGTWAQVRTSLKTQ	CPT1C	386	Q8TCG5
QPRKCSSRRNAWGNL	FOXO3B	231	A0A2Z4LIS9
ICQTVLKGKWPSARR	CHD9	2271	Q3L8U1
QWSKLPCGITSRNRI	DCLRE1C	266	Q96SD1
VQTLCRNAFPKGSWT	DOK1	111	Q99704
LNKWIPTCAQLFTSR	DNAH3	401	Q8TD57
GVWIKTDSNPTLRRN	FBXO11	711	Q86XK2
TWRDCLFRPLNKQVT	CUL1	166	Q13616
QQWTAICPLKERRFG	GAN	446	Q9H2C0
GRPFSIICLKNSVWT	CR1L	71	Q2VPA4
PSTWRGACKTAVQLL	GARRE1	401	O15063
SQPIGKVREFWRCNS	COBL	761	O75128
LILRSCTGQRWTIKN	GALNT17	581	Q6IS24
THGKTRWTQPQLICT	IL2RA	171	P01589
GRPVLCGSKWRLSNN	MCRS1	416	Q96EZ8
AQRPGSVSKWVRLNV	KCTD5	36	Q9NXV2
RLNPDCWKRKRTNSG	HBP1	496	O60381
VGSECTRTVTPLRWQ	HELZ2	1541	Q9BYK8
AWNLCSVGKRQSPVN	CA10	56	Q9NS85
WPVICLNKRTRRSIQ	CHIC1	161	Q5VXU3
TALVQATCRKNGWPL	DNAH10	4336	Q8IVF4
NTKVFGRPISSWTCL	SEC14L1	381	Q92503
CSRGNRLKTTSWGLL	SCNN1D	241	P51172
ILFSNCPQGLTTWRK	CFAP47	961	Q6ZTR5
CPQGLTTWRKAILQN	CFAP47	966	Q6ZTR5
LCNWVSRRADQGPKT	EIF4G3	981	O43432
TCSSRRPINRQWLRK	PKD1L1	1541	Q8TDX9
RCWLVFRKSSSKGPQ	DOK4	26	Q8TEW6
QAPNVDWLRTLRGCS	D2HGDH	86	Q8N465
QPRKCSSRRNAWGNL	FOXO3	146	O43524
TRGLCSKGQPRTWLQ	RTKN	546	Q9BST9
QRSKWGRTCPVNLKD	AK9	331	Q5TCS8
QWVQRQRLERKGTCP	PNKD	316	Q8N490
CPNDTGGLRSLVNKW	SEMA3C	266	Q99985
IQWITTQCRKDVGRP	TAGLN2	31	P37802
MAGPNQLCIRRWTTK	SAMD8	1	Q96LT4
RRDWVQCPKSQTPGS	NCKAP5	881	O14513
RVTQRKPSSGPVCWL	PHF7	21	Q9BWX1
PLKSVRCNNEQWGLR	SPATA31A6	1286	Q5VVP1
APSCTQRITWKGLLL	PSG9	6	Q00887
TCKSLQQSLLRRWGE	FBXL18	656	Q96ME1
IRCRSNGKWDRPQIV	NCAN	1256	O14594
SQGSVTAWRKICPLF	SLC6A12	101	P48065
LTQGVCPRRWKLQVL	PRAMEF27	91	A3QJZ7
NRQSVSECKVWRNPL	ST7	126	Q9NRC1
SECKVWRNPLNLFRG	ST7	131	Q9NRC1
REKITNCPSVNDGRW	SVEP1	1496	Q4LDE5
TCRSLGRSLWQQPSV	URB1	1576	O60287
PSLTKWTLNIVNLRC	SIX6OS1	176	Q8N1H7
QPQSTEKRGWLSLRL	CLEC6A	6	Q6EIG7
ALWPVQCALKTGNLR	RNF223	211	E7ERA6
IKLLSRRPRNWSQCV	UBA6	686	A0AVT1
RLRQRICKSSILQWP	TLR8	991	Q9NR97
SPANSSPRGKWQCRI	ZNF451	596	Q9Y4E5
RKWRCAGQVTIQGPA	STK35	91	Q8TDR2
CLRKGESGQSWPRLT	PTGES3	76	Q15185
LRAWRTGKTVSPQSN	SCAF1	151	Q9H7N4
LSPWVGSLQKGQRLC	THEMIS2	276	Q5TEJ8
TSQGGVTAWRKICPI	SLC6A13	96	Q9NSD5
QLALSTRTVWARCPN	TECPR2	1316	O15040
WQKRTRTCTNPAPLN	UNC5B	266	Q8IZJ1
GWQKRSRTCTNPAPL	UNC5D	271	Q6UXZ4
TKTCWTTLPQFRELG	WNT7A	211	O00755
QLTLCPRNGTVTGKW	TMEM219	66	Q86XT9
ILFRTKPWQCLSVRT	WDR4	86	P57081
VRTCWKQLSPFRETG	WNT9B	221	O14905
QGCPIAKWVVRRSSS	TET2	1191	Q6N021
QPWQVLVASRGRAVC	KLK3	36	P07288