Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX10 ZNF671 ZNF146 ZNF493 ZNF607 ZNF621 E2F5 ZNF112 MED1 ZNF595 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 NFE2L1 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	1.84e-11	1244	103	28	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX10 ZNF671 ZNF146 ZNF493 ZNF607 ZNF875 ZNF621 E2F5 ZNF112 MED1 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 NFE2L1 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	2.73e-11	1459	103	30	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX10 ZNF671 ZNF146 ZNF493 ZNF607 ZNF621 E2F5 ZNF112 MED1 ZNF595 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 NFE2L1 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	3.04e-11	1271	103	28	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX10 ZNF146 ZNF493 ZNF607 ZNF875 ZNF621 E2F5 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 NFE2L1 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	3.46e-10	1412	103	28	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX10 ZNF493 E2F5 ZNF112 ZNF24 ZNF600 ZNF605 NFE2L1 ZNF624 ZNF721 ZNF615 ZFP62	3.51e-05	566	103	12	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX10 ZNF493 ZNF112 ZNF24 ZNF600 ZNF605 NFE2L1 ZNF624 ZNF721 ZNF615 ZFP62	1.48e-04	560	103	11	GO:0001228
MousePheno	abnormal interleukin-1 beta secretion	VSIG4 NLRP1 PIK3CG SLFN11 ATM MAPK3	8.56e-06	101	67	6	MP:0008656
MousePheno	abnormal interleukin-1 secretion	VSIG4 NLRP1 PIK3CG SLFN11 ATM MAPK3	1.33e-05	109	67	6	MP:0008650
Domain	ZINC_FINGER_C2H2_1	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZFR ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	9.83e-17	777	103	29	PS00028
Domain	Znf_C2H2	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZFR ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	2.50e-16	805	103	29	IPR007087
Domain	ZnF_C2H2	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZFR ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	2.76e-16	808	103	29	SM00355
Domain	zf-C2H2	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	4.86e-16	693	103	27	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	8.52e-16	775	103	28	PS50157
Domain	Znf_C2H2-like	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZFR ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	1.68e-15	796	103	28	IPR015880
Domain	-	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	2.84e-15	679	103	26	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	4.76e-15	694	103	26	IPR013087
Domain	zf-C2H2_6	ZNF671 ZNF234 ZNF493 ZNF607 ZNF621 ZNF404 ZNF331 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF792 ZNF408 ZNF624 ZNF721 ZNF615 ZFP62	1.07e-13	314	103	18	PF13912
Domain	KRAB	ZNF671 ZNF234 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF605 ZNF792 ZNF347 ZNF624 ZNF615	9.95e-13	358	103	18	PS50805
Domain	KRAB	ZNF671 ZNF234 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF605 ZNF792 ZNF347 ZNF624 ZNF615	9.95e-13	358	103	18	PF01352
Domain	KRAB	ZNF671 ZNF234 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF605 ZNF792 ZNF347 ZNF624 ZNF615	1.66e-12	369	103	18	SM00349
Domain	KRAB	ZNF671 ZNF234 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF605 ZNF792 ZNF347 ZNF624 ZNF615	1.73e-12	370	103	18	IPR001909
Domain	LAM_G_DOMAIN	EYS FAT2 USH2A	1.19e-03	38	103	3	PS50025
Domain	Laminin_G_2	EYS FAT2 USH2A	1.39e-03	40	103	3	PF02210
Domain	LamG	EYS FAT2 USH2A	1.83e-03	44	103	3	SM00282
Domain	PI3/4_kinase_CS	PIK3CG ATM	3.02e-03	15	103	2	IPR018936
Domain	-	PIK3CG ATM	3.44e-03	16	103	2	1.10.1070.11
Domain	PI3Kc	PIK3CG ATM	3.44e-03	16	103	2	SM00146
Domain	Laminin_G	EYS FAT2 USH2A	4.03e-03	58	103	3	IPR001791
Domain	PI3/4_kinase_cat_dom	PIK3CG ATM	4.35e-03	18	103	2	IPR000403
Domain	PI3_PI4_kinase	PIK3CG ATM	4.35e-03	18	103	2	PF00454
Domain	PI3_4_KINASE_3	PIK3CG ATM	4.35e-03	18	103	2	PS50290
Domain	PI3_4_KINASE_1	PIK3CG ATM	4.35e-03	18	103	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CG ATM	4.35e-03	18	103	2	PS00916
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF671 ZNF234 ZNF493 ZNF607 ZNF875 RICTOR ZNF621 E2F5 ZNF112 MED1 ZNF595 ZNF2 ZNF331 ZNF12 STK11 ZNF677 ZNF600 ZNF605 ZNF792 ZNF347 ZNF624 ZNF721 ZNF615 ATM MAPK3 ZNF415 SMURF2	6.11e-10	1387	74	27	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF493 RICTOR E2F5 ZNF112 MED1 ZNF595 ZNF2 ZNF12 STK11 ZNF605 ZNF347 ZNF624 ZNF721 ATM MAPK3 SMURF2	1.77e-06	768	74	16	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF493 RICTOR E2F5 ZNF112 MED1 ZNF595 ZNF2 ZNF12 STK11 ZNF605 ZNF347 ZNF624 ZNF721 ATM MAPK3 SMURF2	6.36e-05	1022	74	16	MM15436
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF493 ZNF7 ZNF347 ZNF624 ZNF721 ZFP62	8.25e-09	49	105	6	9630514
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF493 ZNF607 ZNF595 ZNF7 ZNF792 ZNF624 ZNF721 ZNF615	8.36e-08	181	105	8	37372979
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ANKRD31 RTEL1 FREM1 BICD1 FAT2 EML5	7.11e-06	152	105	6	34299191
Pubmed	Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.	STK11 ATM	9.03e-06	2	105	2	12234250
Pubmed	DNA Breaks and End Resection Measured Genome-wide by End Sequencing.	RAG2 ATM	9.03e-06	2	105	2	27477910
Pubmed	The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.	RAG2 ATM	9.03e-06	2	105	2	23900513
Pubmed	Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM.	RAG2 ATM	9.03e-06	2	105	2	22709691
Pubmed	Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.	RAG2 ATM	9.03e-06	2	105	2	10841564
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF493 ZNF595 ZNF721	1.18e-05	15	105	3	15885501
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RTEL1 RICTOR NEK9 RAB3GAP1 FAT2 ZNF347 EIF2AK1 MBD5 DHTKD1	1.94e-05	493	105	9	15368895
Pubmed	GIT1 is a scaffold for ERK1/2 activation in focal adhesions.	GIT1 MAPK3	2.70e-05	3	105	2	15923189
Pubmed	SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.	DCLRE1B ATM	2.70e-05	3	105	2	18848520
Pubmed	Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells.	RICTOR PRKCH	2.70e-05	3	105	2	30154443
Pubmed	Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.	MCTS1 MCTS2	2.70e-05	3	105	2	24063864
Pubmed	Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.	RAG2 ATM	2.70e-05	3	105	2	27421701
Pubmed	Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.	DCLRE1B ATM	2.70e-05	3	105	2	18468965
Pubmed	Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor.	PIK3CG MAPK3	2.70e-05	3	105	2	14622970
Pubmed	Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression.	SOX10 MED1	2.70e-05	3	105	2	19852756
Pubmed	PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.	PIK3CG MAPK3	2.70e-05	3	105	2	19457236
Pubmed	Hypoxia promotes epithelial--mesenchymal transition of hepatocellular carcinoma cells via inducing GLIPR-2 expression.	GLIPR2 MAPK3	2.70e-05	3	105	2	24204846
Pubmed	Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.	PIK3CG MAPK3	2.70e-05	3	105	2	19445727
Pubmed	Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.	ATM SMURF2	2.70e-05	3	105	2	33097595
Pubmed	RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.	RAG2 ATM	2.70e-05	3	105	2	11940674
Pubmed	GLIPR-2 overexpression in HK-2 cells promotes cell EMT and migration through ERK1/2 activation.	GLIPR2 MAPK3	2.70e-05	3	105	2	23516513
Pubmed	Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.	RAG2 ATM	2.70e-05	3	105	2	19820166
Pubmed	RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.	RAG2 ATM	2.70e-05	3	105	2	19448632
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF595 ZNF7 ZNF624	2.94e-05	20	105	3	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF595 ZNF7 ZNF624	2.94e-05	20	105	3	2542606
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF234 ZNF112 ZNF404	2.94e-05	20	105	3	12743021
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SOX10 ZNF234 PDE7A GIT1 SPTAN1 BICD1 ZNF331 ZNF7 ZNF605 ZNF624 ATM EIF2AK1 SMURF2 VARS1	3.28e-05	1285	105	14	35914814
Pubmed	A case-by-case evolutionary analysis of four imprinted retrogenes.	MCTS1 MCTS2	5.40e-05	4	105	2	21166792
Pubmed	A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.	RAG2 PRKCH	5.40e-05	4	105	2	21602810
Pubmed	Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.	RAG2 ATM	5.40e-05	4	105	2	19000702
Pubmed	AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.	STK11 ATM	5.40e-05	4	105	2	20864035
Pubmed	Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes.	ATM MAPK3	5.40e-05	4	105	2	19321450
Pubmed	Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines.	PIK3CG MAPK3	5.40e-05	4	105	2	19926313
Pubmed	Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.	PIK3CG MAPK3	5.40e-05	4	105	2	17410437
Pubmed	Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.	STK11 ATM	5.40e-05	4	105	2	11853558
Pubmed	The RAG2 C terminus suppresses genomic instability and lymphomagenesis.	RAG2 ATM	5.40e-05	4	105	2	21368836
Pubmed	IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.	STK11 ATM	5.40e-05	4	105	2	15485651
Pubmed	DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.	STK11 ATM	5.40e-05	4	105	2	15713674
Pubmed	Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia.	PIK3CG MAPK3	5.40e-05	4	105	2	12529294
Pubmed	Network organization of the human autophagy system.	ENPP1 NEK9 FREM1 STK11 RAB3GAP1 ZNF24 PIK3CG VARS1	5.61e-05	437	105	8	20562859
Pubmed	Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.	PIK3CG PRKCH MAPK3	5.86e-05	25	105	3	15689238
Pubmed	ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.	RAG2 ATM	8.97e-05	5	105	2	17599403
Pubmed	Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF.	STK11 MAPK3	8.97e-05	5	105	2	19274086
Pubmed	Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.	PIK3CG MAPK3	8.97e-05	5	105	2	19588500
Pubmed	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.	RAG2 ATM	8.97e-05	5	105	2	26833222
Pubmed	Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling.	PIK3CG MAPK3	8.97e-05	5	105	2	19855431
Pubmed	Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin.	PIK3CG MAPK3	8.97e-05	5	105	2	17942603
Pubmed	Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells.	PIK3CG MAPK3	8.97e-05	5	105	2	18711316
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF493 ZNF595 ZNF721	9.23e-05	29	105	3	14563677
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF7 ZNF12 ZNF24	1.13e-04	31	105	3	2288909
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	SOX10 RICTOR MAPK3	1.24e-04	32	105	3	34193412
Pubmed	A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus.	GPD1 SOX10	1.34e-04	6	105	2	8597630
Pubmed	IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.	PIK3CG MAPK3	1.34e-04	6	105	2	20671123
Pubmed	Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.	ATM MAPK3	1.34e-04	6	105	2	17189385
Pubmed	Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.	STK11 ATM	1.34e-04	6	105	2	23878245
Pubmed	RAG Represents a Widespread Threat to the Lymphocyte Genome.	RAG2 ATM	1.34e-04	6	105	2	26234156
Pubmed	Interaction of Ras with p110γ is required for thymic β-selection in the mouse.	RAG2 PIK3CG	1.34e-04	6	105	2	21930962
Pubmed	Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.	RAG2 ATM	1.34e-04	6	105	2	19450528
Pubmed	ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.	MED1 MAPK3	1.34e-04	6	105	2	23538858
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	TMEM176B SPTAN1 MCTS1 VSIG4 RICTOR E2F5 MED1 ZNF331 GLIPR2 PRKCH SLFN11 CA5B SMURF2	1.43e-04	1293	105	13	15342556
Pubmed	Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.	PIK3CG MAPK3	1.88e-04	7	105	2	19609946
Pubmed	Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.	RAG2 RICTOR	1.88e-04	7	105	2	34623920
Pubmed	LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.	RAG2 STK11	1.88e-04	7	105	2	30049881
Pubmed	The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.	RAG2 ATM	1.88e-04	7	105	2	27559048
Pubmed	The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15.	GPD1 SOX10	1.88e-04	7	105	2	2272507
Pubmed	PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.	RICTOR PIK3CG	1.88e-04	7	105	2	26453378
Pubmed	Characterization of a mouse multigene family that encodes zinc finger structures.	ZNF7 ZNF12	2.50e-04	8	105	2	2452975
Pubmed	A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.	MCTS1 MCTS2	2.50e-04	8	105	2	17291163
Pubmed	The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.	SPTAN1 PIK3CG	3.21e-04	9	105	2	10571082
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	SOX10 USH2A	3.21e-04	9	105	2	23144817
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	GIT1 RICTOR	3.21e-04	9	105	2	27340174
Pubmed	Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice.	SOX10 MAPK3	4.00e-04	10	105	2	33958373
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	MED1 ATM	4.00e-04	10	105	2	17478428
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF493 ZNF721	4.00e-04	10	105	2	18588511
Pubmed	Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.	SOX10 MAPK3	4.00e-04	10	105	2	34519339
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	RICTOR ATM	4.88e-04	11	105	2	20427287
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF493 ZNF721	4.88e-04	11	105	2	15469996
Pubmed	Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain.	SOX10 MAPK3	4.88e-04	11	105	2	21451043
Pubmed	Activator-Mediator binding regulates Mediator-cofactor interactions.	MED1 ATM	4.88e-04	11	105	2	20534441
Pubmed	GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors.	SOX10 MAPK3	4.88e-04	11	105	2	24107967
Pubmed	MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling.	MED1 MAPK3	5.84e-04	12	105	2	18391015
Pubmed	HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?	PRKCH ATM	5.84e-04	12	105	2	18577246
Pubmed	A role for sustained MAPK activity in the mouse ventral telencephalon.	SOX10 MAPK3	6.89e-04	13	105	2	33775695
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF493 ZNF721	6.89e-04	13	105	2	19850934
Pubmed	IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.	RAG2 ATM	6.89e-04	13	105	2	28137874
Pubmed	PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.	MAPK3 BTG4	6.89e-04	13	105	2	32558204
Pubmed	Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve.	SOX10 ZNF7	6.89e-04	13	105	2	35019839
Pubmed	MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.	ZNF7 MAPK3	6.89e-04	13	105	2	9155018
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	SOX10 MAPK3	8.02e-04	14	105	2	34630045
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF595 ZNF7 ZNF624	8.47e-04	61	105	3	8662221
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3CG MAPK3	9.24e-04	15	105	2	18854243
Pubmed	The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.	SOX10 MAPK3	9.24e-04	15	105	2	24599474
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	RICTOR NEK9	9.24e-04	15	105	2	12056414
Pubmed	HIV envelope gp120 activates human arterial smooth muscle cells.	PRKCH MAPK3	9.24e-04	15	105	2	11504923
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	NEK9 STK11 PRKCH SLFN11 ASB2 EIF2AK1	9.51e-04	372	105	6	22939624
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	GPD1 SH3BP4 STK11 RAB3GAP1 EYS EML5 CAPN7 GLIPR2 PRKCH MBD5	1.02e-03	1016	105	10	19056867
Pubmed	Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.	MED1 KIAA0319	1.05e-03	16	105	2	27721240
Interaction	ZNF473 interactions	RICTOR ZNF12 ZNF24 ZNF792 ZNF408 ZFP62	3.83e-07	56	102	6	int:ZNF473
Interaction	TRIM28 interactions	ZNF493 ZNF607 SPTAN1 RICTOR ZNF621 IDH2 ZNF112 ZNF595 ZNF2 ZNF331 ZNF7 ZNF12 RAB3GAP1 ZNF600 ZNF792 ZNF624 ZFR ZNF721 ZNF615 ATM SMURF2	1.27e-05	1474	102	21	int:TRIM28
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF671 ZNF146 ZNF234 ZNF607 ZNF875 ZNF112 ZNF404 ZNF331 ZNF677 ZNF600 ZNF792 ZNF347 ZNF615 ZNF415	5.99e-07	1192	105	14	chr19q13
Cytoband	19q13.42	ZNF331 ZNF677 ZNF347 ZNF415	2.02e-04	125	105	4	19q13.42
Cytoband	19q13.31	ZNF234 ZNF404	2.02e-03	29	105	2	19q13.31
Cytoband	2q33.3	CCNYL1 MDH1B	2.16e-03	30	105	2	2q33.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF671 ZNF146 ZNF234 ZNF493 ZNF607 ZNF875 ZNF621 ZNF112 ZNF595 ZNF404 ZNF2 ZNF331 ZNF7 ZNF12 ZNF677 ZNF24 ZNF600 ZNF605 ZNF608 ZNF792 ZNF408 ZNF347 ZNF624 ZNF721 ZNF615 ZSCAN16 ZNF415 ZFP62	1.23e-20	718	74	28	28
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CCL\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPD1 ZNF493 UGT3A1 ZNF112 DCSTAMP ZNF792 ZSCAN16	3.83e-07	193	105	7	21a117cceb562439ca3fe129aad8cac5f5728b1f
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNBD1 AGPAT4 NLRP1 KIAA0319 ZNF677 EYS	9.77e-07	139	105	6	d96e5c17582f1576fa09d6bad35c418b6248448c
ToppCell	CV-Mild-6\|Mild / Virus stimulation, Condition and Cluster	ZNF671 UAP1 NFE2L1 MAPK3 MBD5 ZNF415	3.72e-06	175	105	6	c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ENPP1 RAB3GAP1 CCNYL1 NFE2L1 ZNF624 ASB2	7.55e-06	198	105	6	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GIT1 SPTAN1 HSPA12B ZNF608 PRKCH MAPK3	7.99e-06	200	105	6	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GIT1 SPTAN1 HSPA12B ZNF608 PRKCH MAPK3	7.99e-06	200	105	6	5c092b2ecc081b5d04476c56333c338cd89ab984
Disease	female breast cancer (is_implicated_in)	RTEL1 ATM	2.90e-04	8	96	2	DOID:0050671 (is_implicated_in)
Disease	Peripheral T-Cell Lymphoma	IDH2 ATM	4.63e-04	10	96	2	C0079774
Disease	HOYERAAL-HREIDARSSON SYNDROME	RTEL1 DCLRE1B	4.63e-04	10	96	2	C1846142
Disease	gastric adenocarcinoma (is_implicated_in)	RTEL1 ABCA13	5.65e-04	11	96	2	DOID:3717 (is_implicated_in)
Disease	urinary metabolite measurement	UGT3A1 RICTOR BICD1 SPAG16 DHTKD1	1.25e-03	245	96	5	EFO_0005116
Disease	lung cancer (is_implicated_in)	RTEL1 RICTOR IDH2	1.83e-03	74	96	3	DOID:1324 (is_implicated_in)
Disease	Stomach Carcinoma	STK11 ATM	2.11e-03	21	96	2	C0699791
Disease	memory performance	CNBD1 IGSF11 SH3BP4 ZNF7 EYS BANK1	2.22e-03	409	96	6	EFO_0004874
Disease	lung squamous cell carcinoma (is_implicated_in)	IDH2 ATM	2.76e-03	24	96	2	DOID:3907 (is_implicated_in)
Disease	response to xenobiotic stimulus	ANKRD31 IGSF11 BICD1 PDP1	2.99e-03	182	96	4	GO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYNKLTIVHHPGGKE	BANK1	736	Q8NDB2
KGGPLEHNYRLKQFH	CA5B	116	Q9Y2D0
NGHIHGPLVKLNGDY	BICD1	286	Q96G01
DGLLPLHIASKKGNY	ASB2	336	Q96Q27
SHPYGGALLNKDKIL	ABCA13	4436	Q86UQ4
GRKPDHKNGHYIIPQ	GIT1	236	Q9Y2X7
HGHKAAKINPLFTGQ	DHTKD1	66	Q96HY7
KHPQHNIKIGLYSLG	DCLRE1B	171	Q9H816
NHLNHVSPGQLTKKY	CCNYL1	106	Q8N7R7
HNLRNTLDGYGIHPK	NFE2L1	56	Q14494
SEKHQYIIHGGKTPN	RAG2	86	P55895
YQHGKLTLLHNGEPL	RAB3GAP1	621	Q15042
TPYGHEKKNLLGIHQ	ANO7	266	Q6IWH7
HHCIKKGGNVNQPSY	ANKRD31	506	Q8N7Z5
HKYPFILPHQQVDKG	MCTS1	86	Q9ULC4
HKYPFILPHQQVDKG	MCTS2	86	A0A3B3IRV3
LGHIPANVQIHKKAG	EYS	2286	Q5T1H1
LGHGDKASYRQPKHV	NEK9	406	Q8TD19
LGHFTIHPKKGELQV	FAT2	3366	Q9NYQ8
LHIPNCDKHGLYNLK	IGFBP2	256	P18065
QHGPYLQITHLIRKG	PDZD9	46	Q8IXQ8
HQGDIEKKYHLGVSP	PDE7A	386	Q13946
KDGLYQALKETHPHL	NLRP1	1441	Q9C000
LPGFEVHLKLHGEKQ	DCSTAMP	331	Q9H295
PGIHKFKGQILHSQE	FMO4	161	P31512
DQIIFKILQGPKHGH	FREM1	1666	Q5H8C1
HLDYLKKGHIENPGD	DEPDC1	696	Q5TB30
GTAPYIVGHNLIKAH	LCT	1561	P09848
GTHGSLNHLLKNPVY	ENPP1	586	P22413
PGKHYLDQLNHILGI	MAPK3	246	P27361
HQLEQPHGTLKELYK	HSPA12B	331	Q96MM6
HHQQPIAVGGYKVTL	PDP1	441	Q9P0J1
GPKPYSLHLDHIIQK	RICTOR	486	Q6R327
QIYIHHPKGAKTQEK	ATM	286	Q13315
SIYANGTHLVPGQHK	IGSF11	356	Q5DX21
KPITIGRHAHGDQYK	IDH2	166	P48735
KKYQINLKSHSGPIH	E2F5	211	Q15329
HKNNPIYQFHIEKTG	CAPN7	711	Q9Y6W3
KVLAGLQHPNIVGYH	EIF2AK1	216	Q9BQI3
AHNEYRQKHGVPPLK	GLIPR2	16	Q9H4G4
KIHFQPYQSGHKDLV	MDH1B	461	Q5I0G3
TQHENVKYLPGHKLP	GPD1	56	P21695
QLPTKGIQQHYKHAV	LYRM9	26	A8MSI8
KSDGHHQYKDIPNPL	MBD5	511	Q9P267
YGGLLEHLASPEHKK	CENATAC	86	Q86UT8
IKPLSILKGHHQYGV	EML5	761	Q05BV3
HSLNHIKEIPGIGYK	POLI	256	Q9UNA4
SKHLKGLVNLYNLPG	MED1	151	Q15648
HPYLNKDGSQKGIHA	MUCL3	421	Q3MIW9
LIKHQNIHTGEKPYE	ZNF146	171	Q15072
GALQSYKVHIHPDAG	RTEL1	416	Q9NZ71
YQHLKGKNVIHPFLS	VARS1	556	P26640
VKGTSHQAHLYGLEP	USH2A	4021	O75445
NKKVTVGLYGPKHIH	SH3BP4	471	Q9P0V3
TLGNNGPTHKKLYRH	NEXMIF	1436	Q5QGS0
LEEGPFHKIHKGVYQ	SLFN11	161	Q7Z7L1
FHKIHKGVYQELPNS	SLFN11	166	Q7Z7L1
YLHSQGIVHKDIKPG	STK11	166	Q15831
NGHYELEHLSTPKLK	SNUPN	331	O95149
HEKHPGKLAGYISSL	TMEM176B	116	Q3YBM2
GLLGNTYHGSQKHPK	BTG4	196	Q9NY30
HSIPNLKKSKHINYG	CNBD1	26	Q8NA66
LGPHHFLLLYQKKGQ	PIK3CG	91	P48736
YGEIIQHELKPNGKS	SMURF2	556	Q9HAU4
KQLILHGAYTHPEGG	PRSS53	366	Q2L4Q9
VHVKQKLYHNGHPSP	TMEM240	156	Q5SV17
LSIHQQTHTGEKPYK	ZNF615	611	Q8N8J6
NLKEHQKIHTGVKPY	ZNF624	626	Q9P2J8
HILQTGGATHLKPYA	UGT3A1	461	Q6NUS8
SLNEHKNIHTGEKPY	ZNF595	326	Q8IYB9
GLINHQRIHTGEKPY	ZNF24	321	P17028
PILKDTLHLAKYHGG	ZNF671	171	Q8TAW3
LIQHQKVHSGEKPYE	ZNF671	466	Q8TAW3
LTQHQKIHTGDKPYE	ZNF2	356	Q9BSG1
LAHGHYASPEIKQKL	SPTAN1	1406	Q13813
DLTQHKGIHAGEKPY	ZNF721	111	Q8TF20
ALNQHKKIHTGEKPY	ZNF721	671	Q8TF20
ARGTQPHGYLAKKLH	ZNF408	296	Q9H9D4
TLKKLQRGHSYHGPQ	SPAG16	261	Q8N0X2
YPHLHNAELSKTLGK	SOX10	126	P56693
YPANLAQHGKVHVEK	ZNF607	181	Q96SK3
LSQHQKIHTGEKPYE	ZNF331	146	Q9NQX6
KYQGRLHVSHKVPGD	VSIG4	81	Q9Y279
SKLPGSIQHVYGAQH	TBC1D22A	16	Q8WUA7
HHVAQKKIPYVDTQG	UAP1	351	Q16222
KHDENLYGPIVKHIS	POGLUT2	341	Q6UW63
IHSQGPQYIIHGLKN	TRAV26-1	56	A0A087WT03
LQIHQLIHTGEKPYK	ZNF234	471	Q14588
LQLHQSVHTGEKPYK	ZNF234	611	Q14588
GLSQHKRIHTGEKPY	ZNF404	481	Q494X3
QLSQHQKIHTGEKPY	ZNF347	331	Q96SE7
NLTQHKKIHTGEKPY	ZNF677	501	Q86XU0
LQGHQRVHTGEKPYK	ZNF112	596	Q9UJU3
YGSFVQHQKLHPVEK	ZNF621	331	Q6ZSS3
AGPQTYKEHLEGQKH	ZFR	341	Q96KR1
LTNHQVIHSGKKPYK	ZNF415	391	Q09FC8
GLIQHQRIHTGEKPY	ZSCAN16	306	Q9H4T2
PHPNCNKKYKHINGL	ZNF608	556	Q9ULD9
NYKLKLVHPSTHPGE	ZNF792	616	Q3KQV3
LAGHKQIHSVQKPYK	ZNF493	516	Q6ZR52
SLKNHKGIHLGEKPY	ZFP62	491	Q8NB50
LHIKLEKTHPGDQAY	ZNF12	176	P17014
NPLHLGKHYPEDQKQ	ZNF875	146	P10072
ENPTLLGVLNGKKYH	AGPAT4	236	Q9NRZ5
LKQHTGLHTGEKPYK	ZNF600	681	Q6ZNG1
HQKIHLGEKPYGCIQ	ZNF605	411	Q86T29
LQGKHTNNCHGEKPY	ZNF7	236	P17097
SHPTDYQGEIKQGHK	KIAA0319	376	Q5VV43
GINIPHKFSIHNYKV	PRKCH	241	P24723