Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	2.58e-08	20	32	4	GO:0042800
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2A KMT2C KMT2B	2.08e-07	8	32	3	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2A KMT2C KMT2B	4.45e-07	10	32	3	GO:0140999
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	7.05e-07	44	32	4	GO:0140938
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	4.12e-06	68	32	4	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	4.36e-06	69	32	4	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	4.89e-06	71	32	4	GO:0042054
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	2.15e-05	103	32	4	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	2.32e-05	105	32	4	GO:0008170
GeneOntologyMolecularFunction	histone modifying activity	KMT2A KMT2C KMT2B PHF8 ASH1L	2.97e-05	229	32	5	GO:0140993
GeneOntologyMolecularFunction	unmethylated CpG binding	KMT2A KMT2B	1.11e-04	10	32	2	GO:0045322
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	1.58e-04	172	32	4	GO:0008757
GeneOntologyMolecularFunction	methyltransferase activity	KMT2A KMT2C KMT2B ASH1L	3.58e-04	213	32	4	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	KMT2A KMT2C KMT2B ASH1L	4.33e-04	224	32	4	GO:0016741
GeneOntologyMolecularFunction	polysaccharide binding	AGL CLEC4G	1.12e-03	31	32	2	GO:0030247
GeneOntologyMolecularFunction	modification-dependent protein binding	KMT2A PHF8 AGL	4.31e-03	206	32	3	GO:0140030
GeneOntologyBiologicalProcess	roof of mouth development	EPHB3 JAG2 FRAS1 IFT172	2.23e-05	104	33	4	GO:0060021
GeneOntologyBiologicalProcess	negative regulation of heterochromatin formation	KMT2A PHF8	3.71e-05	6	33	2	GO:0031452
GeneOntologyBiologicalProcess	negative regulation of chromatin organization	KMT2A PHF8	5.19e-05	7	33	2	GO:1905268
GeneOntologyBiologicalProcess	facultative heterochromatin formation	KMT2A KMT2B PHF8	9.25e-05	55	33	3	GO:0140718
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2A KMT2C KMT2B	2.24e-04	75	33	3	GO:0035097
MousePheno	abnormal digit development	JAG2 FRAS1 BMPR1B	1.38e-05	23	29	3	MP:0006280
MousePheno	lethality during fetal growth through weaning, complete penetrance	JAG2 KMT2A HGF TARDBP KMT2C FRAS1 KMT2B NALCN MYO5A IFT172 ARIH2	2.45e-05	1269	29	11	MP:0011111
MousePheno	abnormal digit morphology	ADAMTS17 JAG2 FRAS1 BMPR1B EIF3C IFT172	4.40e-05	323	29	6	MP:0002110
MousePheno	abnormal autopod morphology	ADAMTS17 JAG2 FRAS1 BMPR1B EIF3C IFT172	1.25e-04	390	29	6	MP:0000572
MousePheno	abnormal sternebra morphology	KMT2A FRAS1 BMPR1B	1.66e-04	52	29	3	MP:0004322
MousePheno	abnormal endometrial gland number	BMPR1B ASH1L	2.71e-04	12	29	2	MP:0009095
MousePheno	liver hypoplasia	KMT2A HGF ARIH2	2.80e-04	62	29	3	MP:0000600
MousePheno	abnormal embryonic tissue morphology	JAG2 KMT2A FASTKD5 SMG5 KMT2B NALCN RFX3 MTCH2 IFT172	2.95e-04	1116	29	9	MP:0002085
MousePheno	postnatal growth retardation	KMT2A TARDBP KMT2C FRAS1 EIF3C MYO5A RFX3 ASH1L	3.15e-04	881	29	8	MP:0001732
MousePheno	short metacarpal bones	ADAMTS17 BMPR1B	3.72e-04	14	29	2	MP:0004634
MousePheno	abnormal postnatal growth	KMT2A TARDBP KMT2C FRAS1 EIF3C MYO5A RFX3 ASH1L	3.84e-04	907	29	8	MP:0001731
MousePheno	thin endometrium	BMPR1B ASH1L	4.29e-04	15	29	2	MP:0008258
MousePheno	abnormal axial skeleton morphology	ADAMTS17 JAG2 KMT2A TARDBP FRAS1 BMPR1B MTCH2 AGL ASH1L WDR72	4.60e-04	1458	29	10	MP:0002114
MousePheno	fused phalanges	JAG2 BMPR1B	4.90e-04	16	29	2	MP:0008730
MousePheno	abnormal phalanx morphology	ADAMTS17 JAG2 BMPR1B	5.10e-04	76	29	3	MP:0005306
Domain	Post-SET_dom	KMT2A KMT2C KMT2B ASH1L	1.27e-08	16	32	4	IPR003616
Domain	PostSET	KMT2A KMT2C KMT2B ASH1L	1.27e-08	16	32	4	SM00508
Domain	POST_SET	KMT2A KMT2C KMT2B ASH1L	1.27e-08	16	32	4	PS50868
Domain	FYrich_C	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	IPR003889
Domain	FYrich_N	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	IPR003888
Domain	FYRC	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	SM00542
Domain	FYRN	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	SM00541
Domain	FYRN	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	PF05964
Domain	FYRC	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	PF05965
Domain	FYRC	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	PS51543
Domain	FYRN	KMT2A KMT2C KMT2B	4.56e-08	5	32	3	PS51542
Domain	AT_hook	KMT2A KMT2C KMT2B ASH1L	1.21e-07	27	32	4	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2A KMT2C KMT2B ASH1L	1.21e-07	27	32	4	IPR017956
Domain	PHD	KMT2A KMT2C KMT2B PHF8 ASH1L	1.69e-07	75	32	5	PF00628
Domain	Znf_PHD-finger	KMT2A KMT2C KMT2B PHF8 ASH1L	2.19e-07	79	32	5	IPR019787
Domain	PHD	KMT2A KMT2C KMT2B PHF8 ASH1L	3.99e-07	89	32	5	SM00249
Domain	Znf_PHD	KMT2A KMT2C KMT2B PHF8 ASH1L	4.46e-07	91	32	5	IPR001965
Domain	ZF_PHD_2	KMT2A KMT2C KMT2B PHF8 ASH1L	5.53e-07	95	32	5	PS50016
Domain	ZF_PHD_1	KMT2A KMT2C KMT2B PHF8 ASH1L	5.83e-07	96	32	5	PS01359
Domain	SET	KMT2A KMT2C KMT2B ASH1L	6.87e-07	41	32	4	PF00856
Domain	SET	KMT2A KMT2C KMT2B ASH1L	1.10e-06	46	32	4	SM00317
Domain	SET_dom	KMT2A KMT2C KMT2B ASH1L	1.55e-06	50	32	4	IPR001214
Domain	SET	KMT2A KMT2C KMT2B ASH1L	1.55e-06	50	32	4	PS50280
Domain	MeTrfase_trithorax	KMT2A KMT2B	2.84e-06	2	32	2	IPR016569
Domain	Znf_FYVE_PHD	KMT2A KMT2C KMT2B PHF8 ASH1L	4.79e-06	147	32	5	IPR011011
Domain	EPHD	KMT2A KMT2C KMT2B	6.88e-06	22	32	3	PS51805
Domain	-	KMT2A KMT2C KMT2B PHF8 RFPL2 ARIH2 ASH1L	8.86e-06	449	32	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2A KMT2C KMT2B PHF8 RFPL2 ARIH2 ASH1L	1.02e-05	459	32	7	IPR013083
Domain	zf-CXXC	KMT2A KMT2B	1.55e-04	11	32	2	PF02008
Domain	Znf_CXXC	KMT2A KMT2B	1.55e-04	11	32	2	IPR002857
Domain	ZF_CXXC	KMT2A KMT2B	1.55e-04	11	32	2	PS51058
Domain	AT_hook	KMT2A KMT2C	3.36e-04	16	32	2	PF02178
Domain	VWC_out	JAG2 FRAS1	4.78e-04	19	32	2	SM00215
Domain	DHHC	KMT2C ZDHHC6	8.32e-04	25	32	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	KMT2C ZDHHC6	8.32e-04	25	32	2	IPR001594
Domain	VWFC_1	JAG2 FRAS1	1.73e-03	36	32	2	PS01208
Domain	VWC	JAG2 FRAS1	1.92e-03	38	32	2	SM00214
Domain	VWFC_2	JAG2 FRAS1	1.92e-03	38	32	2	PS50184
Domain	BROMODOMAIN_2	KMT2A ASH1L	2.24e-03	41	32	2	PS50014
Domain	BROMO	KMT2A ASH1L	2.35e-03	42	32	2	SM00297
Domain	Bromodomain	KMT2A ASH1L	2.35e-03	42	32	2	IPR001487
Domain	-	KMT2A ASH1L	2.35e-03	42	32	2	1.20.920.10
Domain	VWF_dom	JAG2 FRAS1	2.35e-03	42	32	2	IPR001007
Domain	Growth_fac_rcpt_	EPHB3 JAG2 FRAS1	2.37e-03	156	32	3	IPR009030
Domain	Zinc_finger_PHD-type_CS	PHF8 ASH1L	5.53e-03	65	32	2	IPR019786
Domain	SH3_2	DNMBP ZDHHC6	9.50e-03	86	32	2	IPR011511
Domain	SH3_2	DNMBP ZDHHC6	9.50e-03	86	32	2	PF07653
Pathway	WP_HISTONE_MODIFICATIONS	KMT2A KMT2C KMT2B ASH1L	4.08e-06	65	24	4	M39374
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2A KMT2C KMT2B ASH1L	5.50e-06	70	24	4	M27231
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2A KMT2C KMT2B	4.77e-05	42	24	3	M48018
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2A KMT2B ASH1L	6.27e-05	46	24	3	MM14933
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2A KMT2C KMT2B PHF8 ASH1L	8.11e-05	272	24	5	M29619
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2A KMT2B PHF8 ASH1L	2.01e-04	175	24	4	MM14941
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	KMT2A KMT2C KMT2B	5.58e-04	96	24	3	M27792
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2A KMT2C KMT2B ASH1L	4.69e-11	8	33	4	23130995
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KMT2A KMT2C KMT2B ASH1L	4.77e-10	13	33	4	24619213
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2A KMT2C KMT2B	3.11e-09	4	33	3	23129768
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2A KMT2C KMT2B	4.34e-08	8	33	3	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2A KMT2C KMT2B	6.51e-08	9	33	3	22665483
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT2A KMT2C KMT2B PHF8	1.38e-07	49	33	4	34368113
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2A KMT2C KMT2B	1.70e-07	12	33	3	27563068
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2A KMT2C KMT2B ASH1L	2.56e-07	57	33	4	18022353
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2A KMT2C KMT2B	4.32e-07	16	33	3	23870121
Pubmed	KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.	KMT2A KMT2B	8.73e-07	2	33	2	28723559
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2A KMT2C KMT2B	1.02e-06	21	33	3	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2A KMT2C KMT2B	1.18e-06	22	33	3	26886794
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	KMT2A KMT2C KMT2B	2.51e-06	28	33	3	27256596
Pubmed	Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.	KMT2A MYO5A	2.62e-06	3	33	2	8327517
Pubmed	Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells.	HGF BMPR1B	2.62e-06	3	33	2	17203235
Pubmed	miR-142-3p down-regulation contributes to thyroid follicular tumorigenesis by targeting ASH1L and MLL1.	KMT2A ASH1L	2.62e-06	3	33	2	25238203
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2A KMT2C	2.62e-06	3	33	2	23932714
Pubmed	Human transcription factor protein interaction networks.	KMT2A TARDBP KMT2C TIMM8A SMG5 EIF3C KMT2B PHF8 MYO5A	5.13e-06	1429	33	9	35140242
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2B	5.23e-06	4	33	2	19221051
Pubmed	WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.	KMT2A KMT2B	5.23e-06	4	33	2	18840606
Pubmed	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.	KMT2A KMT2C	5.23e-06	4	33	2	19703992
Pubmed	Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.	KMT2A KMT2B	5.23e-06	4	33	2	26267306
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2A KMT2C	5.23e-06	4	33	2	24081332
Pubmed	Bone morphogenetic proteins, eye patterning, and retinocollicular map formation in the mouse.	EPHB3 BMPR1B	5.23e-06	4	33	2	18614674
Pubmed	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.	KMT2A KMT2B	5.23e-06	4	33	2	31534153
Pubmed	Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.	KMT2A KMT2B	5.23e-06	4	33	2	17166833
Pubmed	Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.	KMT2A KMT2B	5.23e-06	4	33	2	25834037
Pubmed	Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.	KMT2A KMT2B	5.23e-06	4	33	2	34156981
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2A KMT2B	8.72e-06	5	33	2	26320581
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	KMT2A KMT2B	8.72e-06	5	33	2	25561738
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2A KMT2B	8.72e-06	5	33	2	28609655
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2A KMT2C KMT2B	9.36e-06	43	33	3	33472061
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KMT2A KMT2C KMT2B	1.00e-05	44	33	3	24183668
Pubmed	Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.	KMT2A ASH1L	1.31e-05	6	33	2	25866973
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2A KMT2B	1.31e-05	6	33	2	16199523
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2A KMT2B	1.31e-05	6	33	2	24176642
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2B	1.31e-05	6	33	2	17021013
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2A KMT2C KMT2B	1.48e-05	50	33	3	37974198
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2B	1.83e-05	7	33	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2A KMT2C	1.83e-05	7	33	2	36598580
Pubmed	A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.	KMT2C KMT2B	1.83e-05	7	33	2	19433796
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2A KMT2C	1.83e-05	7	33	2	26324722
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2B	1.83e-05	7	33	2	19556342
Pubmed	HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.	KMT2A HGF	2.44e-05	8	33	2	23934123
Pubmed	Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.	TIMM8A ARIH2	2.44e-05	8	33	2	22037423
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	KMT2A KMT2C KMT2B	2.70e-05	61	33	3	20305087
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2A KMT2B	3.13e-05	9	33	2	16951254
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2A KMT2B	3.91e-05	10	33	2	29276034
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	KMT2A TARDBP KMT2C FASTKD5 EIF3C KMT2B	4.94e-05	711	33	6	33022573
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2B	6.77e-05	13	33	2	21502505
Pubmed	BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.	JAG2 BMPR1B	9.10e-05	15	33	2	16324690
Pubmed	Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.	KMT2A KMT2C	9.10e-05	15	33	2	35907431
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2B	1.04e-04	16	33	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2B	1.18e-04	17	33	2	26180087
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	FRAS1 IFT172	1.32e-04	18	33	2	26921296
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2B	1.32e-04	18	33	2	17500065
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2A TARDBP KMT2C KMT2B PHF8	1.59e-04	549	33	5	38280479
Pubmed	Tbx1 regulates oral epithelial adhesion and palatal development.	EPHB3 JAG2	1.64e-04	20	33	2	22371266
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2B	1.64e-04	20	33	2	19047629
Pubmed	Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.	TIMM8A ZDHHC6	1.81e-04	21	33	2	15328023
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	TARDBP ZDHHC6 AGL TPBG	1.97e-04	306	33	4	18973680
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2A KMT2C KMT2B	1.98e-04	119	33	3	23508102
Pubmed	The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.	RFX3 IFT172	1.99e-04	22	33	2	19887680
Pubmed	ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.	RFX3 IFT172	1.99e-04	22	33	2	25294941
Pubmed	The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.	KMT2A ASH1L	2.18e-04	23	33	2	17203973
Pubmed	Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.	JAG2 BMPR1B	2.18e-04	23	33	2	14701881
Pubmed	Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.	KMT2A KMT2B	2.58e-04	25	33	2	25664857
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	EPHB3 JAG2 FRAS1 BMPR1B	2.65e-04	331	33	4	20634891
Pubmed	BMP receptor 1b is required for axon guidance and cell survival in the developing retina.	EPHB3 BMPR1B	3.02e-04	27	33	2	12654290
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	KMT2C ASH1L	3.74e-04	30	33	2	17403666
Pubmed	Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.	FASTKD5 MYO5A	3.74e-04	30	33	2	37019383
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2B	3.99e-04	31	33	2	20516061
Pubmed	Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.	MYO5A WDR72	3.99e-04	31	33	2	30642949
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KMT2A KMT2C EIF3C KMT2B DNMBP MYO5A MTCH2	4.31e-04	1497	33	7	31527615
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KMT2A PHF8	4.53e-04	33	33	2	26864203
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	TARDBP TIMM8A	4.81e-04	34	33	2	16611982
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAG2 KMT2C FRAS1 SMG5 KMT2B DNMBP	5.39e-04	1105	33	6	35748872
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C MYO5A	5.39e-04	36	33	2	16097034
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KMT2A BMPR1B EIF3C KMT2B ARIH2	5.86e-04	730	33	5	34857952
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FRAS1 EIF3C DNMBP RFX3	5.94e-04	410	33	4	26949251
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KMT2C KMT2B PHF8 GFRAL AGL	6.08e-04	736	33	5	29676528
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	RFX3 IFT172	6.66e-04	40	33	2	32317081
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2A EIF3C KMT2B PHF8 DNMBP	7.63e-04	774	33	5	15302935
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	NRAP PHF8 RFX3 ZDHHC6 ASH1L	9.25e-04	808	33	5	20412781
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	SMG5 ASH1L	1.21e-03	71	33	2	chr1q22
GeneFamily	PHD finger proteins	KMT2A KMT2C KMT2B PHF8 ASH1L	6.73e-08	90	22	5	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2A KMT2C KMT2B ASH1L	7.44e-08	34	22	4	487
GeneFamily	Zinc fingers CXXC-type	KMT2A KMT2B	9.26e-05	12	22	2	136
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	6.11e-06	162	33	4	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	6.41e-06	164	33	4	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	Adult-Epithelial-basal_cell-D231\|Adult / Lineage, Cell type, age group and donor	JAG2 FRAS1 BMPR1B TPBG	8.10e-06	174	33	4	a4f98afe7d1cc2617f6f7bc8092c41df57474b30
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	9.46e-06	181	33	4	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	JAG2 FRAS1 BMPR1B TPBG	9.88e-06	183	33	4	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	1.03e-05	185	33	4	a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	1.10e-05	188	33	4	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	1.12e-05	189	33	4	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A WDR72	1.12e-05	189	33	4	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2A KMT2C FRAS1 RFX3	1.32e-05	197	33	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 FRAS1 BMPR1B TPBG	1.32e-05	197	33	4	107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB3 BMPR1B AGL	1.02e-04	123	33	3	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 BMPR1B TPBG	1.60e-04	143	33	3	28e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCell	Basal_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	JAG2 FRAS1 TPBG	2.39e-04	164	33	3	85487a303194f5244956ec1ca2d1758d38117f41
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BMPR1B TPBG CLEC4G	2.75e-04	172	33	3	1d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B MYO5A IFT172	2.80e-04	173	33	3	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BMPR1B RFX3 IFT172	2.95e-04	176	33	3	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	JAG2 BMPR1B TPBG	2.99e-04	177	33	3	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BMPR1B RFX3 TPBG	3.04e-04	178	33	3	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 BMPR1B TPBG	3.04e-04	178	33	3	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	EPHB3 BMPR1B TPBG	3.20e-04	181	33	3	7e3bcfa2ba5b98a7df5854aa6e7a31e9a71faa8a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B WDR72	3.20e-04	181	33	3	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB3 ADAMTS17 HGF	3.30e-04	183	33	3	d2074b13b4831ec18c81273d9a1ff673c3f6a16d
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	HGF NALCN MYO5A	3.35e-04	184	33	3	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HGF MYO5A CLEC4G	3.41e-04	185	33	3	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS17 BMPR1B TPBG	3.41e-04	185	33	3	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.41e-04	185	33	3	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.52e-04	187	33	3	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.57e-04	188	33	3	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	KMT2A KMT2C ASH1L	3.57e-04	188	33	3	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS17 FRAS1 WDR72	3.57e-04	188	33	3	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 BMPR1B WDR72	3.57e-04	188	33	3	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	PBMC-Mild-cDC_12\|Mild / Compartment, Disease Groups and Clusters	EIF3C NALCN WDR72	3.63e-04	189	33	3	946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B MYO5A WDR72	3.63e-04	189	33	3	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.68e-04	190	33	3	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAMTS17 FRAS1 TPBG	3.74e-04	191	33	3	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.74e-04	191	33	3	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 BMPR1B WDR72	3.80e-04	192	33	3	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.80e-04	192	33	3	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BMPR1B MYO5A	3.80e-04	192	33	3	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	EPHB3 HGF TPBG	3.80e-04	192	33	3	d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KMT2A KMT2C ASH1L	3.80e-04	192	33	3	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ASH1L WDR72	3.80e-04	192	33	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 FRAS1 BMPR1B	3.97e-04	195	33	3	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2A KMT2C ASH1L	3.97e-04	195	33	3	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HGF MYO5A CLEC4G	3.97e-04	195	33	3	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	(3)_MNP-(3)_Macrophage_MARCOneg\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	HGF MYO5A CLEC4G	3.97e-04	195	33	3	e4b5e4b8832669fb4d1661ecd828b81e621d35c4
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2A KMT2C ASH1L	3.97e-04	195	33	3	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	JAG2 FRAS1 TPBG	4.03e-04	196	33	3	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HGF BMPR1B NALCN	4.03e-04	196	33	3	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	JAG2 FRAS1 TPBG	4.09e-04	197	33	3	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FRAS1 BMPR1B TPBG	4.09e-04	197	33	3	2701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FRAS1 BMPR1B TPBG	4.09e-04	197	33	3	751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FRAS1 BMPR1B TPBG	4.09e-04	197	33	3	58d809ccb8cc4b1e76acf0b8f996cd0e2637290c
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	HGF BMPR1B NALCN	4.16e-04	198	33	3	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 FRAS1 BMPR1B	4.22e-04	199	33	3	94a7867e800df352731796de8c24cba133c29622
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KMT2A KMT2C ASH1L	4.28e-04	200	33	3	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EPHB3 ADAMTS17 BMPR1B	4.28e-04	200	33	3	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS17 HGF FRAS1	4.28e-04	200	33	3	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2A KMT2C ASH1L	4.28e-04	200	33	3	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate\|10w / Sample Type, Dataset, Time_group, and Cell type.	DNMBP IFT172 CLEC4G	4.28e-04	200	33	3	e5a8647c47a49c8c90c78d681193946de103d8ff
Disease	prostate cancer (is_marker_for)	KMT2A KMT2C KMT2B PHF8	2.41e-05	156	32	4	DOID:10283 (is_marker_for)
Disease	congenital heart disease (implicated_via_orthology)	KMT2A KMT2C KMT2B	5.78e-05	69	32	3	DOID:1682 (implicated_via_orthology)
Disease	dystonia (is_implicated_in)	TIMM8A KMT2B	1.03e-04	14	32	2	DOID:543 (is_implicated_in)
Disease	teratocarcinoma-derived growth factor 1 measurement	KMT2A MYO5A	1.35e-04	16	32	2	EFO_0008297
Disease	Neurodevelopmental Disorders	KMT2A KMT2C ASH1L	1.41e-04	93	32	3	C1535926
Disease	Liver carcinoma	KMT2A HGF KMT2C KMT2B CLEC4G	2.02e-04	507	32	5	C2239176
Disease	Acute Myeloid Leukemia, M1	KMT2A HGF KMT2C	3.36e-04	125	32	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	KMT2A HGF KMT2C	3.36e-04	125	32	3	C1879321
Disease	corpus callosum mid-anterior volume measurement	MTCH2 WDR72	3.93e-04	27	32	2	EFO_0010297
Disease	Malignant neoplasm of liver	ADAMTS17 HGF ASH1L	4.89e-04	142	32	3	C0345904
Disease	Liver neoplasms	ADAMTS17 HGF ASH1L	4.89e-04	142	32	3	C0023903
Disease	Prostatic Neoplasms	KMT2A KMT2C BMPR1B TPBG ASH1L	4.93e-04	616	32	5	C0033578
Disease	Malignant neoplasm of prostate	KMT2A KMT2C BMPR1B TPBG ASH1L	4.93e-04	616	32	5	C0376358
Disease	S100 calcium-binding protein B measurement	KMT2A NALCN	7.82e-04	38	32	2	EFO_0600012
Disease	Leukemia, Myelocytic, Acute	KMT2A HGF KMT2C	8.67e-04	173	32	3	C0023467
Disease	asparagine measurement	FRAS1 RFX3	9.10e-04	41	32	2	EFO_0009766
Disease	Carcinoma, Transitional Cell	KMT2A KMT2C	9.10e-04	41	32	2	C0007138
Disease	oral microbiome measurement	KMT2C FRAS1	9.55e-04	42	32	2	EFO_0801229

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGLMIQCDKCMVWQH	ASH1L	2596	Q9NR48
QCDKCMVWQHCDCMG	ASH1L	2601	Q9NR48
AAVSMWDVCMERGHR	DNMBP	1061	Q6XZF7
NHMQCSKCKHDFCWM	ARIH2	311	O95376
ECLRQMGKLMTECWA	BMPR1B	461	O00238
FCRNMEHLMCAGLWC	ADAMTS17	486	Q8TE56
IDCWCMLQKEGNMSR	MTCH2	266	Q9Y6C9
EMWKGSACEFCMCDH	FRAS1	296	Q86XX4
DMLHCNMCKRWVHLE	KMT2C	481	Q8NEZ4
WHKACFHCEVCKMML	NRAP	26	Q86VF7
CMDGWMGKECKEAVC	JAG2	231	Q9Y219
MDCPTALHQLMLDCW	EPHB3	861	P54753
ESKMMQCAQCDHWVH	KMT2B	1351	Q9UMN6
TCSMWDKNMEDLHRH	HGF	411	P14210
AGRWEQAHKLAMKCM	IFT172	951	Q9UG01
EMWGKCLDCINELMD	EIF3C	396	Q99613
KCCHQVWEMNMDQLL	FASTKD5	231	Q7L8L6
CLRDANGCKHAWRVM	GFRAL	31	Q6UXV0
NGCKHAWRVMEDACN	GFRAL	36	Q6UXV0
GMKRMGHRTCLWNDQ	KLHDC9	311	Q8NEP7
YESKMMQCGKCDRWV	KMT2A	1581	Q03164
GKEMDWAQMACHRCL	SMG5	161	Q9UPR3
VMSQRHMIDGRWCDC	TARDBP	161	Q13148
HESILKWMCNCDHGM	RFX3	421	P48380
KWMCNCDHGMYQALV	RFX3	426	P48380
RENCVMMLHTGLWND	CLEC4G	261	Q6UXB4
CVMKMDHHCPWINNC	ZDHHC6	121	Q9H6R6
LKADACLNSHMGAMW	ZNF75CP	6	Q92670
PDWINCMCIVHSMRI	WDR72	156	Q3MJ13
CAVLCGHWDFADMMV	RFPL2	21	O75678
MIECDMCQDWFHGSC	PHF8	56	Q9UPP1
LDNNPWVCDCHMADM	TPBG	291	Q13641
VHQMTELCWEKCMDK	TIMM8A	36	O60220
KACFLMAHNGWVMGD	AGL	451	P35573
VTGEDWNKIMHDCMV	NALCN	1386	Q8IZF0
CELMGVDYEEMCHWL	MYO5A	361	Q9Y4I1