Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 GPR179 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

8.85e-1188414027GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPC1 OR7D4 OR10A7 GPR17 TRHR IL17REL OR7C1 OR4D10 GPR173 TMEM63C OR1A2 PTCH1 OR2B6 F2RL2 OR2L13 OR52N1 GPR179 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 TLR4 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

8.27e-10135314032GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

9.60e-0943114017GO:0004984
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 TLR4 C4B OR2Z1 OR7A17 OR52M1 OR7G3

3.61e-0952414219GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

7.69e-0943214217GO:0050911
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR7D4 OR10A7 KLK6 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 ADCY7 GPR179 CCKBR OR51G2 GPR180 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

1.87e-08139514230GO:0007186
GeneOntologyBiologicalProcesssensory perception of smell

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

2.27e-0846514217GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

4.19e-0848514217GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 TLR4 OR2Z1 OR7A17 OR52M1 OR7G3

1.08e-0758214218GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 PITPNM1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 TLR4 C4B OR2Z1 OR7A17 OR52M1 OR7G3

1.20e-0772214220GO:0051606
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

2.33e-0754714217GO:0007606
GeneOntologyBiologicalProcesssensory perception

OR7D4 CACNA1E OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 GPR179 SLC52A3 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 TLR4 OR2Z1 OR7A17 OR52M1 OR7G3 USH2A

4.16e-06107214222GO:0007600
GeneOntologyCellularComponentCul3-RING ubiquitin ligase complex

KLHL2 KLHL20 KLHL3 KLHL25

1.36e-04391414GO:0031463
DomainGPCR_Rhodpsn_7TM

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

1.91e-1267013526IPR017452
Domain7tm_1

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

2.42e-1267713526PF00001
DomainG_PROTEIN_RECEP_F1_1

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

3.16e-1268513526PS00237
DomainG_PROTEIN_RECEP_F1_2

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

3.84e-1269113526PS50262
DomainGPCR_Rhodpsn

OR7D4 OR10A7 GPR17 TRHR OR7C1 OR4D10 GPR173 OR1A2 OR2B6 F2RL2 OR2L13 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 ACKR3 GPR68 MTNR1B OR2Z1 OR7A17 OR52M1 OR7G3 GPR132

3.97e-1269213526IPR000276
DomainOlfact_rcpt

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

3.69e-0939313517IPR000725
DomainBTB

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

4.67e-051311357PF00651
DomainDienelactn_hydro

ABHD17A TEX30

1.55e-0431352IPR002925
DomainDLH

ABHD17A TEX30

1.55e-0431352PF01738
DomainBTB

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

1.64e-041601357PS50097
DomainAa_trans

SLC38A5 TMEM104 SLC38A1

2.33e-04171353PF01490
DomainAA_transpt_TM

SLC38A5 TMEM104 SLC38A1

2.33e-04171353IPR013057
DomainC345C

C4A C4B PCOLCE

2.33e-04171353SM00643
DomainBTB-kelch_protein

KLHL2 KLHL20 KLHL3 KLHL25

2.59e-04431354IPR017096
DomainNTR

C4A C4B PCOLCE

3.29e-04191353PF01759
DomainNetrin_module_non-TIMP

C4A C4B PCOLCE

3.29e-04191353IPR018933
DomainBTB

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

3.38e-041801357SM00225
DomainBTB/POZ_dom

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

3.98e-041851357IPR000210
DomainSKP1/BTB/POZ

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

4.53e-041891357IPR011333
DomainAnaphylatoxin_comp_syst

C4A C4B

5.11e-0451352IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

5.11e-0451352IPR001840
DomainNTR

C4A C4B PCOLCE

5.88e-04231353PS50189
DomainNetrin_domain

C4A C4B PCOLCE

5.88e-04231353IPR001134
DomainKelch

KLHL2 KLHL20 KLHL3 KLHL25

8.19e-04581354SM00612
DomainTIMP-like_OB-fold

C4A C4B PCOLCE

8.50e-04261353IPR008993
DomainGal_Oxase/kelch_b-propeller

KLHL2 KLHL20 KLHL3 KLHL25

8.73e-04591354IPR011043
DomainBACK

KLHL2 KLHL20 KLHL3 KLHL25

9.31e-04601354SM00875
Domain-

KLHL2 KLHL20 KLHL3

9.51e-042713532.130.10.80
DomainBACK

KLHL2 KLHL20 KLHL3 KLHL25

9.90e-04611354IPR011705
DomainBACK

KLHL2 KLHL20 KLHL3 KLHL25

9.90e-04611354PF07707
DomainANATO

C4A C4B

1.06e-0371352SM00104
DomainANAPHYLATOXIN_2

C4A C4B

1.06e-0371352PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.06e-0371352PS01177
DomainANATO

C4A C4B

1.06e-0371352PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

1.06e-0371352IPR000020
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.41e-0381352IPR019565
DomainThiol-ester_cl

C4A C4B

1.41e-0381352PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.41e-0381352IPR019742
DomainKelch_1

KLHL2 KLHL20 KLHL3 KLHL25

1.66e-03701354PF01344
DomainKelch_1

KLHL2 KLHL20 KLHL3 KLHL25

1.66e-03701354IPR006652
DomainHydrolase_4

ABHD17A ABHD17C

1.81e-0391352IPR022742
DomainHydrolase_4

ABHD17A ABHD17C

1.81e-0391352PF12146
DomainPtc/Disp

NPC1 PTCH1

1.81e-0391352IPR003392
DomainPatched

NPC1 PTCH1

1.81e-0391352PF02460
DomainGal_Oxidase_b-propeller

KLHL2 KLHL20 KLHL3

1.88e-03341353IPR015916
DomainA2M

C4A C4B

2.25e-03101352PF00207
DomainA2M_N_2

C4A C4B

2.25e-03101352IPR011625
DomainA2M_comp

C4A C4B

2.25e-03101352IPR011626
DomainRap_GAP

RAP1GAP TSC2

2.25e-03101352PF02145
DomainA2M_recep

C4A C4B

2.25e-03101352PF07677
DomainA2M_comp

C4A C4B

2.25e-03101352PF07678
DomainA2M_N

C4A C4B

2.25e-03101352PF01835
DomainA2M_N

C4A C4B

2.25e-03101352IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.25e-03101352IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.25e-03101352PS00477
DomainA2M_N_2

C4A C4B

2.25e-03101352PF07703
DomainMacroglobln_a2

C4A C4B

2.25e-03101352IPR001599
DomainRap_GAP_dom

RAP1GAP TSC2

2.73e-03111352IPR000331
DomainRAPGAP

RAP1GAP TSC2

2.73e-03111352PS50085
DomainSSD

NPC1 PTCH1

3.84e-03131352IPR000731
DomainSSD

NPC1 PTCH1

3.84e-03131352PS50156
DomainLaminin_N

LAMA3 USH2A

5.82e-03161352IPR008211
DomainLamNT

LAMA3 USH2A

5.82e-03161352SM00136
DomainLAMININ_NTER

LAMA3 USH2A

5.82e-03161352PS51117
DomainLaminin_N

LAMA3 USH2A

5.82e-03161352PF00055
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 PRKACG OR2Z1 OR7A17 OR52M1 OR7G3

3.74e-1038910318M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

8.19e-0941710317M4072
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

GPR17 TRHR OR7C1 GPR173 OR1A2 OR2B6 F2RL2 CCKBR ACKR3 GPR68 MTNR1B OR7A17

4.15e-0726010312M39397
PathwayREACTOME_SENSORY_PERCEPTION

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

3.28e-0663610317M41834
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR7D4 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

1.43e-113401441511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR7D4 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

1.43e-113401441511802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR7D4 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

1.62e-113431441532295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR7D4 OR7C1 OR4D10 OR1A2 OR2B6 OR2L13 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

1.83e-113461441514611657
Pubmed

The human olfactory receptor gene family.

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2B6 OR52N1 OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR2Z1 OR7A17 OR52M1 OR7G3

1.04e-095411441614983052
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 SEMA6C HECTD4 ELP6 PAPLN TSC2 MLLT10 PTCH1 TEP1 ZBTB42 ADCY7 SLC52A3 KLHL25 RPAP1 SGSM2 ESPL1 RIC1

3.55e-0611051441735748872
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR7D4 OR10A7 OR7C1 OR4D10 OR1A2 OR2Z1 OR7A17 OR7G3

3.93e-06219144812213199
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR7C1 OR1A2 OR2Z1 OR7A17 OR7G3

1.45e-0574144515081110
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.70e-052144222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.70e-052144216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.70e-052144215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.70e-052144219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.70e-052144219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.70e-05214422459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.70e-052144217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.70e-052144212207352
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.70e-052144227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.70e-052144222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.70e-052144223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.70e-052144223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.70e-05214423037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.70e-052144211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.70e-05214424216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.70e-05214426950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.70e-05214428660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.70e-05214428428773
Pubmed

Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice.

CCKBR TLR4

1.70e-052144218054398
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.70e-052144224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.70e-052144221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.70e-05214422572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.70e-05214422302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.70e-052144222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.70e-052144218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.70e-052144229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.70e-05214426589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.70e-052144225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.70e-052144217728371
Pubmed

Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7.

ACKR3 TLR4

1.70e-052144224363762
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.70e-05214426149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.70e-05214426149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.70e-052144212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.70e-05214423542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.70e-05214422387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.70e-052144216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.70e-05214427365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.70e-05214427391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.70e-052144217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.70e-052144229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.70e-052144217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.70e-05214426881182
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.70e-052144217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.70e-052144221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.70e-05214426978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

1.70e-052144235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

1.70e-052144228873507
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

1.70e-0521442276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

1.70e-05214426832377
Pubmed

Association of Nod-like receptor protein-1 (rs2670660) and Toll-like receptor-4 (rs4986790) with non-segmental vitiligo: A case-control study in South Indian population.

NLRP1 TLR4

1.70e-052144231293094
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

1.70e-05214423794341
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

1.70e-052144222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

1.70e-052144232691186
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

1.70e-05214428390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

1.70e-05214423902619
Pubmed

Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation.

TLR4 NOS3

1.70e-052144222432744
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

1.70e-05214427373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

1.70e-05214423696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

1.70e-05214421357031
Pubmed

Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma.

ACKR3 TLR4

1.70e-052144222180778
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

1.70e-052144216098595
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

1.70e-052144215787745
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

1.70e-052144230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

1.70e-05214426559257
Pubmed

Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.

GPR68 GPR132

1.70e-052144227049592
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

1.70e-052144234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

1.70e-052144220506482
Pubmed

[G894T (NOS3) and G1958A (MTHFD1) gene polymorphisms and risk of ischemic heart disease in Yucatan, Mexico].

MTHFD1 NOS3

1.70e-052144225304051
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

1.70e-052144212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

1.70e-052144226800705
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

1.70e-052144215390104
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

1.70e-05214421699796
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

1.70e-05214422997024
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

1.70e-05214423624865
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

1.70e-052144221857912
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

1.70e-05214426208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

1.70e-05214424514997
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

1.70e-05214425919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

1.70e-05214423167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

1.70e-05214427545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

1.70e-052144230041577
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

1.70e-05214423862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

1.70e-052144234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

1.70e-052144218360261
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

1.70e-052144226814963
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

1.70e-05214428132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

1.70e-05214422395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

1.70e-052144226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

1.70e-05214426192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

1.70e-05214426167582
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

1.70e-05214421438267
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

1.70e-052144219150565
Cytoband11p15.4

DNHD1 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR52M1

1.62e-08200144911p15.4
CytobandEnsembl 112 genes in cytogenetic band chr11p15

DNHD1 SAAL1 OR52N1 CCKBR OR51G2 OR51E1 OR52R1 OR51I1 OR51M1 OR52M1

1.28e-0556414410chr11p15
CytobandEnsembl 112 genes in cytogenetic band chr17p13

ACAP1 NLRP1 OR1A2 CAMTA2 BCL6B SGSM2

8.18e-043461446chr17p13
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ABHD17A OR7D4 OR7C1 MAU2 YJEFN3 PIK3R2 OR2Z1 OR7A17 OR7G3

9.73e-047971449chr19p13
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL2 PATZ1 ZBTB42 KLHL20 BCL6B KLHL3 KLHL25

5.06e-06134917861
GeneFamilyKelch like|BTB domain containing

KLHL2 KLHL20 KLHL3 KLHL25

5.81e-0542914617
GeneFamilyOlfactory receptors, family 51

OR51G2 OR51E1 OR51I1 OR51M1

6.99e-0544914164
GeneFamilyG protein-coupled receptors, Class A orphans

GPR17 GPR173 GPR68 GPR132

6.45e-0478914262
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

8.82e-0499121234
GeneFamilyOlfactory receptors, family 52

OR52N1 OR52R1 OR52M1

1.92e-0349913165
GeneFamilyOlfactory receptors, family 7

OR7D4 OR7C1 OR7A17 OR7G3

2.55e-03113914154
Diseasecryptic phenotype measurement

SLC27A6 MLLT10 ABHD17C NOS3

5.54e-05471304EFO_0021487
DiseaseAbruptio Placentae

MTHFD1 NOS3

5.76e-0531302C0000832
Diseasevitiligo (is_implicated_in)

NLRP1 TLR4 C4A

1.05e-04211303DOID:12306 (is_implicated_in)
DiseaseOther License Status

TSC2 KLHL3

1.15e-0441302C3889261
Diseaserespiratory allergy (is_implicated_in)

TLR4 NOS3

1.91e-0451302DOID:0060496 (is_implicated_in)
DiseaseSYSTEMIC LUPUS ERYTHEMATOSUS 16

C4A DNASE1

1.91e-0451302C3280742
DiseaseCalcium channel blocker use measurement

SLC27A6 ABHD17C SLC38A1 TMEM106C TRIM36 NOS3

3.74e-042131306EFO_0009930
Diseasefocal segmental glomerulosclerosis (is_marker_for)

RAP1GAP TMEM63C

5.30e-0481302DOID:1312 (is_marker_for)
Diseasehelping behavior measurement

SLC52A3 USH2A

5.30e-0481302EFO_0008538
Diseasesystemic lupus erythematosus (implicated_via_orthology)

C4A C4B DNASE1

9.07e-04431303DOID:9074 (implicated_via_orthology)
DiseaseGastrointestinal Stromal Sarcoma

NPC1 PTCH1 TMEM231

1.18e-03471303C3179349
DiseaseN-acetylputrescine measurement

SLC38A1 TUBGCP6

1.24e-03121302EFO_0800127
DiseaseGastrointestinal Stromal Tumors

NPC1 PTCH1 TMEM231

1.41e-03501303C0238198
Diseasebirth weight, parental genotype effect measurement

PTCH1 SLC38A1 KLHL25 MTNR1B NOS3

1.64e-031921305EFO_0004344, EFO_0005939
Diseasemetabolic syndrome

NPC1 HECTD4 MLLT10 SLC38A1 MTNR1B

1.96e-032001305EFO_0000195
Disease4-acetamidobutanoate measurement

SLC38A1 MOV10L1

2.22e-03161302EFO_0021003
Diseasesphingomyelin 18:0 measurement

AGBL4 IPO11

2.22e-03161302EFO_0010393
DiseaseAtherosclerosis

NPC1 TLR4 NOS3

2.27e-03591303C0004153
DiseaseAtherogenesis

NPC1 TLR4 NOS3

2.27e-03591303C1563937
DiseaseNecrotizing Enterocolitis

TLR4 NOS3

2.51e-03171302C0520459
Diseasesystemic lupus erythematosus (is_implicated_in)

C4A C4B DNASE1

2.61e-03621303DOID:9074 (is_implicated_in)
DiseaseAlzheimer's disease (is_implicated_in)

KLK6 CLOCK TLR4 NOS3

2.81e-031321304DOID:10652 (is_implicated_in)
DiseaseCoronary Arteriosclerosis

HECTD4 TLR4 NOS3

2.99e-03651303C0010054
DiseaseCoronary Artery Disease

HECTD4 TLR4 NOS3

2.99e-03651303C1956346
DiseaseFamilial aplasia of the vermis

TCTN3 TMEM231

3.47e-03201302cv:C0431399
DiseaseLupus Erythematosus, Systemic

C4A C4B DNASE1

3.84e-03711303C0024141
Diseaseamblyopia

CACNA1E TLR4

4.20e-03221302MONDO_0001020

Protein segments in the cluster

PeptideGeneStartEntry
CVSSPHFQVAERALY

PPP2R5E

351

Q16537
FSTTNPIRRACHYIV

CACNA1E

1136

Q15878
HVLLYFDSVPTSREC

C4B

1521

P0C0L5
VVIHSADAFAPVAYL

DPH6

226

Q7L8W6
AIVLAIFLVCFVPYH

GPR17

266

Q13304
IFLVCFVPYHVNRSV

GPR17

271

Q13304
VFLRHEFPRVYEQLC

AJM1

911

C9J069
AEHYSCVFDHIAVPA

CAMTA2

561

O94983
SRYECAAVVLHSPLT

ABHD17A

201

Q96GS6
HYLAASRAFVVGICD

ACAP1

51

Q15027
ERCARELAHFPYVVV

ADCK5

286

Q3MIX3
AVAVLDFIHYCRATV

ELP6

156

Q0PNE2
ESVLYGVCAHFPRLF

DNHD1

1346

Q96M86
PRARHDFACASLIFV

ADCY7

591

P51828
PISFIHLLSYASACV

CCKBR

371

P32239
FKPHTACVTALAYER

CFAP44

571

Q96MT7
LHPACRYDALEVFAG

PCOLCE

86

Q15113
RENILFHLYVSTSPC

ADARB2

476

Q9NS39
CIAHYDSPEAAVAVV

ARHGAP39

986

Q9C0H5
PFCVVERTSQIYLHH

RIC1

816

Q4ADV7
ADLAPAAVLFVYTLH

OVOS1

461

Q6IE37
DRAVAISCPLHYTTI

OR1A2

121

Q9Y585
DRFVAICNPLHYSVI

OR10A7

121

Q8NGE5
DRFVAICRPLHYSVI

OR2B6

121

P58173
FYHRELEVCADPTVV

MOV10L1

986

Q9BXT6
EFSAEYVRPQVHCIA

LAMA3

1041

Q16787
CSPLAVVAYERLAHV

GREB1

956

Q4ZG55
AQHLYVTLRTIPHFC

IL17REL

86

Q6ZVW7
CYATRAVLSAFHEPR

GPR179

561

Q6PRD1
YLTCESFPHAVDHIL

HDHD2

241

Q9H0R4
AAATYVQEFLPHSIC

PHKA1

1206

P46020
HPNCLYTVELEAFAI

CFAP65

721

Q6ZU64
VELFYRLHCLAPTAN

DOP1B

896

Q9Y3R5
ITYCTADGRHPRVFA

FAM43B

146

Q6ZT52
RPCTEVLFIDIFHEY

IPO11

406

Q9UI26
RVCRSGFVEYSHLLP

LBHD1

186

Q9BQE6
VIHFLLPIAVVSFCY

MTNR1B

206

P49286
SIPLERIHFDSYITC

FBXO33

391

Q7Z6M2
PGSVVTRVHFCYDVR

TMEM63C

246

Q9P1W3
AFDRYVAICHPLRHA

OR51E1

121

Q8TCB6
SITLHFPYCASRIVD

OR2Z1

161

Q8NG97
DRFVAICHPLHYVSI

OR51G2

126

Q8NGK0
HICAVLAFYVPIIAV

OR51I1

246

Q9H343
SFDRLVAICHPLRYS

OR51M1

131

Q9H341
YDATLPFHCSAILAT

MSTO1

321

Q9BUK6
VSIPLHACEHFYLLT

PDPR

256

Q8NCN5
HACEHFYLLTRPLET

PDPR

261

Q8NCN5
VTFHLYLIPSDCSIR

NLRP1

1246

Q9C000
PRAYIFSDCHSRVLE

EEF2KMT

181

Q96G04
CISIISHEYTRRPAF

DEFB125

56

Q8N687
CYTRLSHFSLQPVLD

TUBGCP6

406

Q96RT7
AQDLVDFSPVYRCLH

EXOC6B

286

Q9Y2D4
HPVLACISVIFSDYQ

GPR180

371

Q86V85
ETVHIPGARCLYLRF

HECTD4

651

Q9Y4D8
DALREVILPYSAAHC

OLIG1

126

Q8TAK6
VPYFLTHITLEIDCS

LRRC8B

276

Q6P9F7
PVSLHVRTSDCAYFI

SMPD4

211

Q9NXE4
AYPHFCAFARAVDTR

NOS3

656

P29474
CISINRYLAIVHPFT

F2RL2

186

O00254
THFLYCVRAPASLND

NPC1

511

O15118
YVAICFPLRHSSILT

OR52R1

126

Q8NGF1
SFPAHRAVLAACSEY

PATZ1

51

Q9HBE1
DRFVAICHPLHYTVI

OR7D4

121

Q8NG98
EPLTFCSVVDLINHY

PIK3R2

391

O00459
DRFVAVCHPLHYTVI

OR7C1

121

O76099
LCLGHRDPYATAFLV

ESPL1

1606

Q14674
EPHACFYAAQVVLAV

PRKACG

141

P22612
AHRVILSACSPYFRA

KLHL20

81

Q9Y2M5
AFPCHRAVLAASSRY

KLHL25

56

Q9H0H3
ACHRFIQASYEPLGI

BCL6B

126

Q8N143
ATPTHCAYDRIVVAG

DNASE1

226

P24855
PCDIVIDHHVSYAAF

CCDC73

701

Q6ZRK6
FLVSQHPIACVLREY

AGBL4

246

Q5VU57
HYIPFTCRLEHALFT

ACKR3

281

P25106
ASRYECAAVILHSPL

ABHD17C

221

Q6PCB6
RSAVCFPFVLASVRH

GPR173

71

Q9NS66
FVKACAVPHRYLATA

GPR173

311

Q9NS66
YFEHRVTIFTVPENC

DSC1

241

Q08554
IEAHRVVLAACSPYF

KLHL3

61

Q9UH77
RINEIVYFLPFCHSE

CLPB

561

Q9H078
RIQEHPAIYDSICFI

SAAL1

176

Q96ER3
PVSSHCLRAAAFYVR

MAU2

451

Q9Y6X3
RYSGLCPHVVVLVAT

MTHFD1

686

P11586
CALAALIHFYCPDVV

CAMSAP2

256

Q08AD1
HVLLYFDSVPTSREC

C4A

1521

P0C0L4
ADPVLYCFVSETTHR

GPR68

281

Q15743
LAHTVFALHIPYCRS

OR2L13

156

Q8N349
AFDRYVAICNPLRHS

OR52M1

121

Q8NGK5
SHLCAILIFYVPIAV

OR52M1

246

Q8NGK5
ALDHCVAICFPLRYA

OR52N1

121

Q8NH53
PNVLDTFYCDVHRVL

OR4D10

171

Q8NGI6
AVVVIFLVCFAPYHL

GPR132

246

Q9UNW8
LLVHPTCSFDITYDR

SMG8

211

Q8ND04
YFFCTVPEILVHNIV

TMEM106C

201

Q9BVX2
PFHRYEIRIQACTTL

USH2A

4601

O75445
RQVDCSHTLYPAFAL

TRIM36

691

Q9NQ86
CPAHLAFIYTLVAFV

SLC52A3

296

Q9NQ40
CTLRDFPGVYTHVQI

PRSS29P

286

A6NIE9
ITAFTIERYIAICHP

TRHR

116

P34981
RIGFYPINHTDCLVS

MMP23B

141

O75900
IHLACTAGIFDAYVP

MRPL45

76

Q9BRJ2
AFAFVCHPEVLPIYT

SLC38A5

266

Q8WUX1
DRFVAICHPLRYNVI

OR7G3

121

Q8NG95
FIEVFHELCTRPEIY

PLCL2

331

Q9UPR0
HRPSYCDAAFALEQI

PTCH1

51

Q13635
YALVVPFSQVVCIHC

SGSM2

316

O43147
RTYHDVIPISCLTEF

RAP1GAP

136

P47736
SAVLSAHFRVCEPYT

SHISAL1

21

Q3SXP7
DRFVAICHPLHYTVI

OR7A17

121

O14581
IPSAARVHYGCVIFV

SLC17A7

161

Q9P2U7
DSPLAVHLYCRLFQT

MRPS2

241

Q9Y399
SHIDTCLHAYIFRPE

TASOR

596

Q9UK61
STFDPCFYRELVVVH

B3GNT9

351

Q6UX72
AHVVCALYIPEVQFA

MLLT10

101

P55197
LHSAIYAARPDVRCI

ADD2

211

P35612
HRPSYEDRVCFVATV

CLOCK

241

O15516
LTVTRFYNRPLHCVF

CNNM1

496

Q9NRU3
LDRLYGHPATCLAVF

GTF2H4

31

Q92759
YHLPFLRDVQTDCTR

INPP5J

516

Q15735
CILAVFFHTPYRRLQ

SLC49A3

436

Q6UXD7
EEAPRAAAALCTLYH

TNIP2

11

Q8NFZ5
IYNLFHAADPCASRL

PITPNM1

726

O00562
FTCLYRVRVHGSVAP

SUN5

351

Q8TC36
IRSGVYSHLEAFVPC

UBN2

501

Q6ZU65
YLPAVAAVCVARASH

TYMSOS

26

Q8TAI1
HLRRYFCAIVQLPSD

TEP1

321

Q99973
TLPEFCAAFHLIVAR

REPS2

336

Q8NFH8
SRLVFCTIDHEAYPD

PAPLN

326

O95428
VIPAFLVYHCRRDTQ

TMEM104

436

Q8NE00
CARHLRVFEYEPTIF

YJEFN3

136

A6XGL0
HDTRIHVCLYFITPT

SEPTIN8

146

Q92599
HRLFVAFSGCIVYLP

SEMA6C

501

Q9H3T2
DDFVRGLICISYPLH

TEX30

121

Q5JUR7
HFLDPYCSALVAGAR

RHPN2P1

436

A8MT19
CPVLYAVAVAHVNSF

RPAP1

1301

Q9BWH6
LPAAAVVYLGFLCHS

TMEM88B

71

A6NKF7
CFTYLHRALESSIAP

RUVBL1

311

Q9Y265
YFSRLLRSDFCPEHV

TLCD1

221

Q96CP7
PAHRAVLAACSVYFH

ZBTB42

36

B2RXF5
LFSHPVERSYRAGLC

TMEM231

6

Q9H6L2
FGCTAHDIVYITLPL

SLC27A6

251

Q9Y2P4
DRDCYLLHPRTVFSF

TCTN3

106

Q6NUS6
SQPVFEYILHCLRTT

TUT7

611

Q5VYS8
CLHYRDFIPGVAIAA

TLR4

706

O00206
TIFPSRICHRELYSV

PRR11

101

Q96HE9
VYALPTIAFAFVCHP

SLC38A1

276

Q9H2H9
FNFVHVIVTPLDYEC

TSC2

1666

P49815
EISAHRVVLAACSPY

KLHL2

66

O95198
FPDTIQCAYIHLVSR

KLK6

151

Q92876