Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

SCN10A MYO15A MYO7A USH1G SLC26A4

2.21e-05238305GO:0050954
GeneOntologyBiologicalProcessinner ear morphogenesis

MYO15A MYO7A USH1G GLI2

3.53e-05129304GO:0042472
GeneOntologyBiologicalProcessactin filament-based movement

SCN10A CASQ2 MYO7A SCN7A

6.86e-05153304GO:0030048
GeneOntologyBiologicalProcessear morphogenesis

MYO15A MYO7A USH1G GLI2

7.04e-05154304GO:0042471
GeneOntologyBiologicalProcessequilibrioception

MYO7A USH1G

7.32e-059302GO:0050957
GeneOntologyBiologicalProcesssensory perception of sound

MYO15A MYO7A USH1G SLC26A4

1.86e-04198304GO:0007605
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN10A CASQ2 SCN7A

3.30e-0493303GO:0086003
GeneOntologyCellularComponentnuclear speck

SETD1B RAD54L2 HECTD1 PABPN1 USH1G GLI2

2.90e-05431306GO:0016607
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN10A SCN7A

2.67e-0417302GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN10A SCN7A

7.89e-0429302GO:0034706
GeneOntologyCellularComponentnuclear body

SETD1B RAD54L2 HECTD1 PABPN1 USH1G GLI2

1.56e-03903306GO:0016604
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN10A CASQ2 OSTM1 SCN7A

1.99e-03378304GO:0034702
GeneOntologyCellularComponentphotoreceptor connecting cilium

MYO7A USH1G

2.16e-0348302GO:0032391
GeneOntologyCellularComponentciliary base

USH1G GLI2

2.92e-0356302GO:0097546
GeneOntologyCellularComponentmyosin complex

MYO15A MYO7A

3.24e-0359302GO:0016459
GeneOntologyCellularComponentcluster of actin-based cell projections

MYO15A MYO7A SLC26A4

3.93e-03223303GO:0098862
GeneOntologyCellularComponentstereocilium

MYO15A MYO7A

4.40e-0369302GO:0032420
GeneOntologyCellularComponentmembrane protein complex

SCN10A CASQ2 ERBB3 COPA OSTM1 CHMP5 SCN7A

4.51e-031498307GO:0098796
GeneOntologyCellularComponentcation channel complex

SCN10A CASQ2 SCN7A

4.55e-03235303GO:0034703
GeneOntologyCellularComponentphotoreceptor inner segment

MYO7A USH1G

5.59e-0378302GO:0001917
GeneOntologyCellularComponentstereocilium bundle

MYO15A MYO7A

5.73e-0379302GO:0032421
GeneOntologyCellularComponentciliary transition zone

MYO7A USH1G

6.01e-0381302GO:0035869
GeneOntologyCellularComponenttransmembrane transporter complex

SCN10A CASQ2 OSTM1 SCN7A

6.34e-03523304GO:1902495
GeneOntologyCellularComponentactin-based cell projection

CA9 MYO15A MYO7A

7.24e-03278303GO:0098858
GeneOntologyCellularComponentlateral plasma membrane

ERBB3 TBCD

7.37e-0390302GO:0016328
GeneOntologyCellularComponenttransporter complex

SCN10A CASQ2 OSTM1 SCN7A

7.55e-03550304GO:1990351
MousePhenoabnormal cochlear hair cell inter-stereocilial links morphology

MYO15A MYO7A USH1G

4.76e-079263MP:0004577
MousePhenoabsent cochlear hair cells

MYO15A USH1G SLC26A4

1.24e-0612263MP:0004405
MousePhenoabnormal inner hair cell stereociliary bundle morphology

MYO15A MYO7A USH1G SLC26A4

1.33e-0645264MP:0004532
MousePhenovestibular saccular macula degeneration

MYO7A USH1G SLC26A4

1.61e-0613263MP:0004331
MousePhenodecreased cochlear hair cell number

MYO15A MYO7A USH1G SLC26A4

2.59e-0653264MP:0004408
MousePhenoabnormal otolith organ morphology

MYO15A MYO7A USH1G SLC26A4

3.01e-0655264MP:0004425
MousePhenoabnormal utricular macula morphology

MYO15A USH1G SLC26A4

3.82e-0617263MP:0004333
MousePhenoabnormal vestibular saccular macula morphology

MYO7A USH1G SLC26A4

6.38e-0620263MP:0004330
MousePhenoabnormal stationary movement

SCN10A MYO15A MYO7A USH1G SLC26A4

6.61e-06147265MP:0001388
MousePhenoabnormal cochlear hair cell number

MYO15A MYO7A USH1G SLC26A4

7.06e-0668264MP:0004406
MousePhenohead shaking

MYO15A MYO7A USH1G

8.59e-0622263MP:0002730
MousePhenoabnormal vestibular labyrinth morphology

MYO15A MYO7A USH1G SLC26A4

1.35e-0580264MP:0004427
MousePhenoimpaired swimming

MYO15A MYO7A USH1G SLC26A4

1.35e-0580264MP:0001522
MousePhenoabnormal inner ear vestibule morphology

MYO15A MYO7A USH1G SLC26A4

1.42e-0581264MP:0000034
MousePhenoabnormal cochlear hair cell stereociliary bundle morphology

MYO15A MYO7A USH1G SLC26A4

2.25e-0591264MP:0004521
MousePhenoabnormal pinna reflex

MYO15A MYO7A USH1G SLC26A4

3.40e-05101264MP:0001485
MousePhenohead tossing

MYO7A USH1G SLC26A4

3.59e-0535263MP:0005307
MousePhenoabnormal head movements

MYO15A MYO7A USH1G SLC26A4

3.67e-05103264MP:0000436
MousePhenocochlear hair cell degeneration

MYO15A MYO7A USH1G SLC26A4

4.11e-05106264MP:0004362
MousePhenoabnormal sensory ganglion morphology

ERBB3 FKBP8 MYO15A MYO7A SLC26A4

4.74e-05221265MP:0000960
MousePhenoshort cochlear outer hair cells

MYO7A USH1G

4.97e-056262MP:0004466
MousePhenoabnormal cochlear hair cell physiology

MYO15A MYO7A USH1G

5.39e-0540263MP:0004432
MousePhenoabnormal utricle morphology

MYO15A USH1G SLC26A4

5.81e-0541263MP:0006090
MousePhenoabsent distortion product otoacoustic emissions

MYO15A MYO7A USH1G

5.81e-0541263MP:0004737
MousePhenodeafness

MYO15A MYO7A USH1G SLC26A4

5.84e-05116264MP:0001967
MousePhenocircling

MYO15A MYO7A USH1G SLC26A4

6.04e-05117264MP:0001394
MousePhenohead tilt

MYO15A MYO7A SLC26A4

7.19e-0544263MP:0005191
MousePhenoabnormal stria vascularis morphology

MYO15A MYO7A SLC26A4

7.19e-0544263MP:0000048
MousePhenoabnormal cochlear inner hair cell morphology

MYO15A MYO7A USH1G SLC26A4

7.58e-05124264MP:0004393
MousePhenoabnormal vestibular saccule morphology

MYO7A USH1G SLC26A4

8.22e-0546263MP:0006089
MousePhenoabnormal vestibular hair cell morphology

MYO7A USH1G SLC26A4

9.35e-0548263MP:0002623
MousePhenoabnormal hair cell physiology

MYO15A MYO7A USH1G

9.94e-0549263MP:0003879
MousePhenoabnormal vestibular system physiology

MYO7A USH1G SLC26A4

9.94e-0549263MP:0004742
MousePhenohead bobbing

MYO15A MYO7A SLC26A4

1.12e-0451263MP:0001410
MousePhenothin stria vascularis

MYO7A SLC26A4

1.48e-0410262MP:0004364
MousePhenoabsent cochlear microphonics

MYO7A USH1G

1.48e-0410262MP:0004413
MousePhenoneurodegeneration

SH3TC2 ERBB3 MYO15A MYO7A USH1G SLC26A4

1.77e-04468266MP:0002229
MousePhenoabnormal cochlear outer hair cell morphology

MYO15A MYO7A USH1G SLC26A4

1.98e-04159264MP:0004399
MousePhenocochlear degeneration

MYO15A MYO7A SLC26A4

2.01e-0462263MP:0000032
MousePhenofused inner hair cell stereocilia

MYO7A SLC26A4

2.17e-0412262MP:0004533
MousePhenoabnormal outer hair cell stereociliary bundle morphology

MYO15A MYO7A USH1G

2.64e-0468263MP:0004527
MousePhenoabnormal cranial ganglia morphology

ERBB3 MYO15A MYO7A SLC26A4

2.86e-04175264MP:0001081
MousePhenostria vascularis degeneration

MYO7A SLC26A4

2.99e-0414262MP:0004363
MousePhenoincreased type II pneumocyte number

COPA GLI2

2.99e-0414262MP:0010810
MousePhenoabnormal sensory neuron physiology

MYO15A MYO7A USH1G

3.13e-0472263MP:0010055
MousePhenodecreased sensory neuron number

MYO15A MYO7A USH1G SLC26A4

3.25e-04181264MP:0000966
MousePhenovestibular hair cell degeneration

USH1G SLC26A4

3.44e-0415262MP:0004324
MousePhenoshort cochlear hair cell stereocilia

MYO15A MYO7A

4.45e-0417262MP:0004524
MousePhenoabnormal somatic nervous system physiology

MYO15A MYO7A USH1G

4.76e-0483263MP:0005423
MousePhenoabnormal cochlear hair cell morphology

MYO15A MYO7A USH1G SLC26A4

4.93e-04202264MP:0002622
MousePhenoabnormal cochlear microphonics

MYO7A USH1G

5.00e-0418262MP:0004412
MousePhenoabnormal distortion product otoacoustic emission

MYO15A MYO7A USH1G

5.10e-0485263MP:0004736
MousePhenoabnormal otoacoustic response

MYO15A MYO7A USH1G

5.28e-0486263MP:0006336
MousePhenocochlear outer hair cell degeneration

MYO7A USH1G SLC26A4

5.28e-0486263MP:0004404
MousePhenoabnormal cochlear sensory epithelium morphology

MYO15A MYO7A USH1G SLC26A4

5.41e-04207264MP:0003308
MousePhenoabnormal cochlear potential

MYO7A USH1G

5.58e-0419262MP:0006332
MousePhenoabnormal organ of Corti morphology

MYO15A MYO7A USH1G SLC26A4

5.61e-04209264MP:0000042
MousePhenoabnormal cochlear ganglion morphology

MYO15A MYO7A SLC26A4

5.64e-0488263MP:0002855
MousePhenodecreased neuron number

ERBB3 MYO15A MYO7A USH1G SLC26A4

5.66e-04376265MP:0008948
MousePhenoabsent pinna reflex

MYO15A MYO7A SLC26A4

5.83e-0489263MP:0006358
MousePhenostereotypic behavior

MYO15A MYO7A USH1G SLC26A4

6.13e-04214264MP:0001408
MousePhenoabnormal hair cell morphology

MYO15A MYO7A USH1G SLC26A4

6.13e-04214264MP:0000045
MousePhenoabsent linear vestibular evoked potential

MYO7A USH1G

6.19e-0420262MP:0004813
MousePhenoneuron degeneration

ERBB3 MYO15A MYO7A USH1G SLC26A4

6.76e-04391265MP:0003224
MousePhenoimpaired hearing

MYO15A MYO7A USH1G SLC26A4

7.15e-04223264MP:0006325
MousePhenoabnormal vestibular hair cell stereociliary bundle morphology

MYO7A USH1G

7.51e-0422262MP:0004515
MousePhenoabnormal dorsal-ventral axis patterning

FKBP8 CHMP5

7.51e-0422262MP:0001704
MousePhenoabnormal mechanoreceptor morphology

MYO15A MYO7A USH1G SLC26A4

8.16e-04231264MP:0000972
MousePhenoabnormal cochlear labyrinth morphology

MYO15A MYO7A USH1G SLC26A4

8.70e-04235264MP:0004426
MousePhenoabnormal scala media morphology

MYO15A MYO7A USH1G SLC26A4

8.70e-04235264MP:0003169
MousePhenoincreased or absent threshold for auditory brainstem response

MYO15A MYO7A USH1G SLC26A4

8.84e-04236264MP:0011967
MousePhenobidirectional circling

USH1G SLC26A4

8.95e-0424262MP:0001395
MousePhenosmall dorsal root ganglion

ERBB3 FKBP8

8.95e-0424262MP:0000964
MousePhenodecreased incisor number

OSTM1 GLI2

8.95e-0424262MP:0030609
MousePhenoabnormal cochlea morphology

MYO15A MYO7A USH1G SLC26A4

1.06e-03248264MP:0000031
MousePhenoabnormal cochlear outer hair cell physiology

MYO7A USH1G

1.22e-0328262MP:0004434
MousePhenoabnormal membranous labyrinth morphology

MYO15A MYO7A USH1G SLC26A4

1.30e-03262264MP:0000035
MousePhenoabnormal tail movements

SCN10A MYO7A

1.31e-0329262MP:0001391
MousePhenoabnormal neuron number

ERBB3 MYO15A MYO7A USH1G SLC26A4

1.35e-03456265MP:0008946
MousePhenoabnormal linear vestibular evoked potential

MYO7A USH1G

1.40e-0330262MP:0004812
MousePhenoabnormal basicranium morphology

HECTD1 GLI2 SLC26A4

1.49e-03123263MP:0010029
MousePhenoabnormal somatic sensory system morphology

ERBB3 FKBP8 MYO15A MYO7A USH1G SLC26A4

1.52e-03702266MP:0000959
MousePhenoabnormal ear morphology

MYO15A MYO7A USH1G GLI2 SLC26A4

1.54e-03470265MP:0002102
MousePhenoabnormal tectorial membrane morphology

MYO15A SLC26A4

1.59e-0332262MP:0003149
MousePhenoincreased neural tube apoptosis

FKBP8 RAD54L2

1.70e-0333262MP:0012505
MousePhenoabnormal reflex

SCN10A SH3TC2 ERBB3 MYO15A MYO7A PABPN1 USH1G SLC26A4

1.80e-031294268MP:0001961
MousePhenoabnormal locomotor coordination

MYO15A OSTM1 MYO7A USH1G GLI2 SLC26A4

1.81e-03726266MP:0003312
MousePhenoabnormal orientation of cochlear hair cell stereociliary bundles

MYO7A USH1G

1.91e-0335262MP:0004522
DomainIQ_motif_EF-hand-BS

SCN10A MYO15A MYO7A SCN7A

1.09e-0590294IPR000048
DomainMYTH4

MYO15A MYO7A

8.32e-059292PS51016
DomainMyTH4_dom

MYO15A MYO7A

8.32e-059292IPR000857
DomainMyTH4

MYO15A MYO7A

8.32e-059292SM00139
DomainMyTH4

MYO15A MYO7A

8.32e-059292PF00784
DomainNa_channel_asu

SCN10A SCN7A

1.04e-0410292IPR001696
DomainNa_trans_assoc

SCN10A SCN7A

1.04e-0410292IPR010526
DomainNa_trans_assoc

SCN10A SCN7A

1.04e-0410292PF06512
DomainIQ

SCN10A MYO15A MYO7A

1.79e-0471293PF00612
DomainIQ

MYO15A MYO7A SCN7A

2.65e-0481293SM00015
DomainIQ

SCN10A MYO15A MYO7A

3.98e-0493293PS50096
DomainMYOSIN_MOTOR

MYO15A MYO7A

1.58e-0338292PS51456
DomainMyosin_head

MYO15A MYO7A

1.58e-0338292PF00063
DomainMyosin_head_motor_dom

MYO15A MYO7A

1.58e-0338292IPR001609
DomainMYSc

MYO15A MYO7A

1.58e-0338292SM00242
DomainFERM_M

MYO15A MYO7A

2.31e-0346292PF00373
DomainFERM_central

MYO15A MYO7A

2.62e-0349292IPR019748
DomainFERM_domain

MYO15A MYO7A

2.62e-0349292IPR000299
DomainFERM_1

MYO15A MYO7A

2.72e-0350292PS00660
DomainFERM_2

MYO15A MYO7A

2.72e-0350292PS00661
DomainBand_41_domain

MYO15A MYO7A

2.72e-0350292IPR019749
DomainB41

MYO15A MYO7A

2.72e-0350292SM00295
DomainFERM_3

MYO15A MYO7A

2.72e-0350292PS50057
DomainChannel_four-helix_dom

SCN10A SCN7A

3.52e-0357292IPR027359
Domain-

SCN10A SCN7A

3.52e-03572921.20.120.350
DomainSH3

SH3TC2 MYO15A MYO7A

4.47e-03216293PS50002
DomainSH3

SH3TC2 MYO15A MYO7A

4.47e-03216293SM00326
DomainSH3_domain

SH3TC2 MYO15A MYO7A

4.70e-03220293IPR001452
DomainSH3_2

SH3TC2 MYO15A

7.85e-0386292IPR011511
DomainSH3_2

SH3TC2 MYO15A

7.85e-0386292PF07653
DomainTPR_1

SH3TC2 FKBP8

8.57e-0390292PF00515
DomainTPR_1

SH3TC2 FKBP8

8.57e-0390292IPR001440
DomainIon_trans_dom

SCN10A SCN7A

1.35e-02114292IPR005821
DomainIon_trans

SCN10A SCN7A

1.35e-02114292PF00520
PathwayREACTOME_SENSORY_PROCESSING_OF_SOUND_BY_OUTER_HAIR_CELLS_OF_THE_COCHLEA

MYO15A MYO7A USH1G

1.37e-0455263M41823
PathwayREACTOME_SENSORY_PROCESSING_OF_SOUND

MYO15A MYO7A USH1G

3.72e-0477263M41822
Pubmed

Heterogeneity of Hereditary Hearing Loss in Iran: a Comprehensive Review.

MYO15A MYO7A SLC26A4

2.32e-09430327743438
Pubmed

Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.

MYO15A MYO7A USH1G

2.02e-08730321436032
Pubmed

Investigation of MYO15A and MYO7A Mutations in Iranian Patients with Nonsyndromic Hearing Loss.

MYO15A MYO7A

7.19e-07230231997689
Pubmed

Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.

MYO7A USH1G

7.19e-07230221311020
Pubmed

Cy3-ATP labeling of unfixed, permeabilized mouse hair cells.

MYO15A MYO7A

7.19e-07230234903829
Pubmed

Novel mutations of MYO7A and USH1G in Israeli Arab families with Usher syndrome type 1.

MYO7A USH1G

2.16e-06330222219650
Pubmed

Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss.

MYO7A SLC26A4

2.16e-06330223770805
Pubmed

Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.

MYO15A MYO7A

2.16e-06330215654330
Pubmed

Myosin 7 and its adaptors link cadherins to actin.

MYO7A USH1G

2.16e-06330228660889
Pubmed

Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation.

MYO7A USH1G

4.31e-06430231644917
Pubmed

Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly.

MYO15A MYO7A

4.31e-06430215590698
Pubmed

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

MYO15A MYO7A

4.31e-06430230275467
Pubmed

Evolution and diversity of mammalian sodium channel genes.

SCN10A SCN7A

4.31e-06430210198179
Pubmed

Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia.

MYO15A MYO7A

4.31e-06430212966030
Pubmed

The role of mouse mutants in the identification of human hereditary hearing loss genes.

MYO15A MYO7A

4.31e-06430210320095
Pubmed

Analysis of subcellular localization of Myo7a, Pcdh15 and Sans in Ush1c knockout mice.

MYO7A USH1G

4.31e-06430221156003
Pubmed

Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.

MYO7A USH1G

7.18e-06530222381527
Pubmed

Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin.

MYO7A USH1G

7.18e-06530212588794
Pubmed

Interactions in the network of Usher syndrome type 1 proteins.

MYO7A USH1G

7.18e-06530215590703
Pubmed

Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.

MYO15A MYO7A

7.18e-06530220332152
Pubmed

Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population.

MYO7A USH1G

7.18e-06530215660226
Pubmed

Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.

MYO7A USH1G

7.18e-06530216219682
Pubmed

Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F.

MYO7A USH1G

7.18e-06530211398101
Pubmed

Dispersed DNA variants underlie hearing loss in South Florida's minority population.

MYO7A SLC26A4

7.18e-06530237996878
Pubmed

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.

MYO15A MYO7A

7.18e-06530218160714
Pubmed

ZBTB20 is essential for cochlear maturation and hearing in mice.

CA9 MYO7A SLC26A4

9.15e-064730337279265
Pubmed

Impact of the Usher syndrome on olfaction.

MYO7A USH1G

1.08e-05630226620972
Pubmed

Genomics and hearing impairment.

MYO15A MYO7A

1.08e-0563029927480
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

SCN10A MYO7A PABPN1 IRX4

1.31e-0516830430631154
Pubmed

Myosins: a diverse superfamily.

MYO15A MYO7A

1.51e-05730210722873
Pubmed

Tails of unconventional myosins.

MYO15A MYO7A

1.51e-05730211212352
Pubmed

The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells.

MYO7A USH1G

1.51e-05730228031293
Pubmed

[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)].

MYO15A MYO7A

1.51e-05730213853422
Pubmed

Usher Syndrome Type I

MYO7A USH1G

1.51e-05730220301442
Pubmed

Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.

MYO7A USH1G

2.01e-05830216545802
Pubmed

Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.

MYO7A USH1G

2.01e-05830219683999
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

MYO7A USH1G

2.01e-05830221165971
Pubmed

UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.

MYO7A USH1G

2.01e-05830218484607
Pubmed

Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.

MYO15A MYO7A

2.01e-05830215702992
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

MYO15A MYO7A

2.58e-05930219339464
Pubmed

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.

MYO7A USH1G

2.58e-05930218339676
Pubmed

Genetic Hearing Loss Overview

MYO15A MYO7A SLC26A4

3.05e-057030320301607
Pubmed

Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.

MYO7A USH1G

3.22e-051030224618850
Pubmed

Usher protein functions in hair cells and photoreceptors.

MYO7A USH1G

3.22e-051030224239741
Pubmed

Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation.

MYO7A GLI2

3.94e-051130236252002
Pubmed

Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.

ERBB3 SLC26A4

3.94e-051130212642503
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

MYO7A USH1G

3.94e-051130231776257
Pubmed

Molecular mechanisms underlying inner ear patterning defects in kreisler mutants.

MYO15A SLC26A4

4.72e-051230216325169
Pubmed

Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation.

MYO15A MYO7A

4.72e-051230229769265
Pubmed

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

MYO15A MYO7A

4.72e-051230228663585
Pubmed

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

MYO15A MYO7A

6.50e-051430226754646
Pubmed

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.

ERBB3 MYO7A

6.50e-051430219936227
Pubmed

Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis.

GLI2 IRX4

8.57e-051630215647317
Pubmed

The role of Pax2 in mouse inner ear development.

MYO15A SLC26A4

9.70e-051730215242798
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

PPP1R18 MICAL3 TBCD

9.94e-0510430331240132
Pubmed

Identification of genes concordantly expressed with Atoh1 during inner ear development.

MYO15A MYO7A

1.22e-041930221519551
Pubmed

A quantitative survey of gravity receptor function in mutant mouse strains.

MYO7A USH1G

1.35e-042030216235133
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

SCN10A COPA HECTD1 TBCD

1.63e-0432230426514267
Pubmed

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.

FKBP8 GLI2

1.64e-042230219223390
Pubmed

A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.

CA9 SLC26A4

1.64e-042230223233153
Pubmed

The small GTPase Rac1 regulates auditory hair cell morphogenesis.

MYO15A MYO7A

1.80e-042330220016102
Pubmed

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

GLI2 CHMP5

1.80e-042330220932654
Pubmed

Notch signaling is essential for ventricular chamber development.

ERBB3 IRX4

2.49e-042730217336907
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

FKBP8 MYO15A COPA HECTD1

2.58e-0436330425036637
Pubmed

Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse.

MYO7A SLC26A4

2.68e-042830220346939
Pubmed

Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.

MYO7A SLC26A4

2.88e-042930225624266
Pubmed

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.

MYO7A USH1G

3.51e-043230223704327
Pubmed

Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.

MYO7A SLC26A4

3.74e-043330224727668
Pubmed

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.

FKBP8 GLI2

3.97e-043430218590716
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

MYO15A MYO7A

6.65e-044430227534441
Pubmed

Mapping of unconventional myosins in mouse and human.

ERBB3 MYO7A

7.92e-04483028884266
Pubmed

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).

CASQ2 COPA

8.25e-044930210051400
Pubmed

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

DPF2 COPA

8.59e-045030227716508
Cytoband9p13.3

CA9 CHMP5

1.11e-03753029p13.3
GeneFamilyActins|Deafness associated genes

MYO15A MYO7A SLC26A4

3.36e-041132231152
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO15A MYO7A

1.67e-03502221293
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

SH3TC2 FKBP8

8.53e-03115222769
GeneFamilyRNA binding motif containing

SETD1B PABPN1

2.73e-02213222725
CoexpressionGSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP

HROB OSTM1 MYO7A PABPN1

5.24e-05181304M6857
CoexpressionGSE1566_WT_VS_EZH2_KO_LN_TCELL_DN

RAD54L2 USH1G SCN7A SPDYE3

7.42e-05198304M6224
CoexpressionGSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_6H_DN

DPF2 COPA OSTM1 PABPN1

7.57e-05199304M6060
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 MYO7A USH1G SCN7A

5.86e-06177304e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 CFAP74 USH1G SCN7A

5.99e-06178304579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA9 CFAP74 USH1G SCN7A

5.99e-06178304b1db59344c074c7c80169fc2c5cd5fc89f3fe463
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; PC3; HT_HG-U133A

NEK3 FKBP8 COPA MYO7A TBCD

5.65e-061983057381_UP
Diseasehearing impairment

MYO15A MYO7A USH1G SLC26A4

2.93e-0698304C1384666
DiseaseUsher syndrome, type 1A

MYO7A USH1G

9.97e-065302C2931205
DiseaseUSHER SYNDROME, TYPE IB (disorder)

MYO7A USH1G

9.97e-065302C1848638
DiseaseUSHER SYNDROME, TYPE IA, FORMERLY

MYO7A USH1G

9.97e-065302C1848639
DiseaseUSHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY

MYO7A USH1G

9.97e-065302C1848640
DiseaseUsher syndrome type 1

MYO7A USH1G

9.97e-065302cv:C1568247
DiseaseHereditary hearing loss and deafness

MYO15A MYO7A USH1G SLC26A4

1.43e-05146304cv:C0236038
DiseaseUsher Syndrome, Type I

MYO7A USH1G

1.50e-056302C1568247
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MYO15A MYO7A SLC26A4

1.91e-0551303cv:CN043650
DiseaseHereditary retinal dystrophy

MYO7A USH1G

2.09e-057302C0154860
DiseaseUsher syndrome

MYO7A USH1G

2.09e-057302cv:C0271097
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN10A SCN7A

4.47e-0510302DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN10A SCN7A

4.47e-0510302DOID:0080422 (implicated_via_orthology)
DiseaseNonsyndromic genetic hearing loss

MYO15A MYO7A SLC26A4

6.34e-0576303cv:C5680182
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN10A SCN7A

6.55e-0512302DOID:0060170 (implicated_via_orthology)
DiseaseNonsyndromic Deafness

MYO15A MYO7A USH1G

7.67e-0581303C3711374
Diseasesensorineural hearing loss (is_implicated_in)

MYO15A MYO7A

5.17e-0433302DOID:10003 (is_implicated_in)
Diseaseheart function measurement

SCN10A CASQ2

5.49e-0434302EFO_0004311
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

GLI2 CHMP5

6.51e-0437302EFO_0001663, EFO_0004234, GO_0009314
DiseaseQRS complex, QRS duration

SCN10A CASQ2

9.63e-0445302EFO_0005054, EFO_0005055

Protein segments in the cluster

PeptideGeneStartEntry
ELPWDELDLGLDEDL

USH1G

371

Q495M9
EPELDLDLDLEAEED

ERBB3

1006

P21860
PDLDPDVELEDAEEE

RAD54L2

11

Q9Y4B4
EDDPLGEEDLPSEED

CA9

56

Q16790
ELSDLDDFDPLEAEP

IRX4

256

P78413
PELDEDDLEAELDAL

CHMP5

156

Q9NZZ3
PLDENDLEEDVDSEP

MICAL3

1066

Q7RTP6
LDIPLPLGDADEEED

MYO15A

501

Q9UKN7
PLGDADEEEDEEELP

MYO15A

506

Q9UKN7
EEELPEADDLDGLLS

HROB

621

Q8N3J3
EADDLDGLLSELPED

HROB

626

Q8N3J3
ADLGLPEDDLVLPDD

GLI2

1051

P10070
DLPDLDPECRELLLD

OSTM1

76

Q86WC4
DPERLEPGLDEEDTD

NEK3

466

P51956
EDEEDLDPDLDPDLE

PATL2

41

C9JE40
LDPDLDPDLEEEEND

PATL2

46

C9JE40
ESEELEPEELLLEPE

PABPN1

51

Q86U42
EEEEEEDDLSELPPL

FKBP8

41

Q14318
LLAELDDDEDLPEPD

HECTD1

1671

Q9ULT8
DVEEDLELPPELDIS

COPA

881

P53621
IPDDDDLPTAEELED

CASQ2

346

O14958
PAAQPDDEEDEEELL

PPP1R18

576

Q6NYC8
DALLLEDERDELEDP

CFAP74

16

Q9C0B2
LSLLDDDEEDEELPR

PWWP3B

366

Q5H9M0
LPEPDDLDDPELLMD

SH3TC2

441

Q8TF17
PLPDSDEDEELDLGL

SETD1B

576

Q9UPS6
EPDEDIEDLEELDIP

SLC26A4

616

O43511
IPELADDLEEPDDCF

SCN10A

1101

Q9Y5Y9
LDESDDEPEKELAPE

SPDYE3

276

A6NKU9
RILEPDDFLDDLDDE

DPF2

156

Q92785
EDHEEEDLKPTPDLE

SCN7A

31

Q01118
PLILTEDDDEDDDVP

TBCD

341

Q9BTW9
DLDAALPLPDEDEED

MYO7A

981

Q13402