Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP44 USP2 USP4 USP16	8.67e-05	114	41	4	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP44 USP2 USP4 USP16	1.20e-04	124	41	4	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP44 USP2 USP4 USP16	1.76e-04	137	41	4	GO:0019783
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO1 TMC6	6.16e-04	18	41	2	GO:0008381
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP44 USP2 USP4 USP16	6.35e-04	192	41	4	GO:0008234
GeneOntologyCellularComponent	collagen type IV trimer	COL4A1 COL4A5	5.60e-05	6	41	2	GO:0005587
GeneOntologyCellularComponent	basement membrane collagen trimer	COL4A1 COL4A5	1.04e-04	8	41	2	GO:0098651
GeneOntologyCellularComponent	network-forming collagen trimer	COL4A1 COL4A5	1.04e-04	8	41	2	GO:0098642
GeneOntologyCellularComponent	collagen network	COL4A1 COL4A5	1.04e-04	8	41	2	GO:0098645
GeneOntologyCellularComponent	complex of collagen trimers	COL4A1 COL4A5	7.70e-04	21	41	2	GO:0098644
Domain	USP_CS	USP44 USP2 USP4 USP16	1.31e-05	66	41	4	IPR018200
Domain	zf-RNPHF	HNRNPH1 HNRNPH2	1.41e-05	3	41	2	PF08080
Domain	Znf_CHHC	HNRNPH1 HNRNPH2	1.41e-05	3	41	2	IPR012996
Domain	USP_1	USP44 USP2 USP4 USP16	1.65e-05	70	41	4	PS00972
Domain	UCH	USP44 USP2 USP4 USP16	1.75e-05	71	41	4	PF00443
Domain	USP_2	USP44 USP2 USP4 USP16	1.75e-05	71	41	4	PS00973
Domain	USP_3	USP44 USP2 USP4 USP16	1.85e-05	72	41	4	PS50235
Domain	USP_dom	USP44 USP2 USP4 USP16	1.85e-05	72	41	4	IPR028889
Domain	Peptidase_C19_UCH	USP44 USP2 USP4 USP16	1.85e-05	72	41	4	IPR001394
Domain	C4	COL4A1 COL4A5	7.01e-05	6	41	2	SM00111
Domain	-	COL4A1 COL4A5	7.01e-05	6	41	2	2.170.240.10
Domain	Collagen_VI_NC	COL4A1 COL4A5	7.01e-05	6	41	2	IPR001442
Domain	NC1_IV	COL4A1 COL4A5	7.01e-05	6	41	2	PS51403
Domain	C4	COL4A1 COL4A5	7.01e-05	6	41	2	PF01413
Domain	ZnF_UBP	USP44 USP16	2.55e-04	11	41	2	SM00290
Domain	zf-UBP	USP44 USP16	4.21e-04	14	41	2	PF02148
Domain	ZF_UBP	USP44 USP16	4.21e-04	14	41	2	PS50271
Domain	Znf_UBP	USP44 USP16	4.21e-04	14	41	2	IPR001607
Domain	ZF_DAG_PE_1	AKAP13 PRKCI	8.70e-03	64	41	2	PS00479
Domain	ZF_DAG_PE_2	AKAP13 PRKCI	8.70e-03	64	41	2	PS50081
Domain	C1	AKAP13 PRKCI	8.96e-03	65	41	2	SM00109
Domain	PE/DAG-bd	AKAP13 PRKCI	9.23e-03	66	41	2	IPR002219
Domain	RRM_1	RBMXL3 HNRNPH1 HNRNPH2	1.06e-02	208	41	3	PF00076
Pathway	WP_MRNA_PROCESSING	HNRNPH1 HNRNPH2 PPM1G EFTUD2	1.80e-04	126	32	4	M39406
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A1 COL4A5	2.22e-04	10	32	2	M22040
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A1 COL4A5	2.22e-04	10	32	2	MM1560
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A1 COL4A5	2.71e-04	11	32	2	M15422
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	USP2 AKAP13 USP4 PRKCI	2.85e-04	142	32	4	MM15431
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A1 COL4A5	3.25e-04	12	32	2	MM1526
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A1 COL4A5	3.83e-04	13	32	2	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A1 COL4A5	3.83e-04	13	32	2	M12950
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	USP2 AKAP13 USP4 PRKCI	3.88e-04	154	32	4	M27697
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A1 COL4A5	4.47e-04	14	32	2	MM1458
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A1 COL4A5	4.47e-04	14	32	2	M6487
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A1 COL4A5	5.15e-04	15	32	2	MM14922
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A1 COL4A5	5.15e-04	15	32	2	M27161
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A1 COL4A5	7.47e-04	18	32	2	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A1 COL4A5	7.47e-04	18	32	2	MM14882
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP44 USP2 USP4 USP16	8.73e-04	191	32	4	MM15289
Pathway	BIOCARTA_AMI_PATHWAY	COL4A1 COL4A5	9.25e-04	20	32	2	M15394
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A1 COL4A5	9.25e-04	20	32	2	MM15061
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A1 COL4A5	1.23e-03	23	32	2	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A1 COL4A5	1.23e-03	23	32	2	MM1427
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	USP2 USP4	1.23e-03	23	32	2	MM15177
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	USP2 USP4	1.45e-03	25	32	2	M27435
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP44 USP2 USP4 USP16	1.50e-03	221	32	4	M27578
Pathway	REACTOME_TIGHT_JUNCTION_INTERACTIONS	PRKCI CLDN10	2.09e-03	30	32	2	M17967
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A1 COL4A5	2.09e-03	30	32	2	M27216
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL4A1 COL4A5	2.37e-03	32	32	2	MM14924
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	USP2 USP4	2.52e-03	33	32	2	M27438
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	USP2 USP4	2.52e-03	33	32	2	MM15180
Pathway	REACTOME_DEUBIQUITINATION	USP44 USP2 USP4 USP16	2.78e-03	262	32	4	MM15286
Pathway	WP_MRNA_PROCESSING	RBMXL3 HNRNPH1 HNRNPH2 PPM1G EFTUD2	3.23e-03	451	32	5	MM15946
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL4A1 COL4A5	3.33e-03	38	32	2	MM14969
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A1 COL4A5	3.87e-03	41	32	2	MM15538
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A1 COL4A5	4.06e-03	42	32	2	M7169
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP2 USP4 USP16	6.85e-07	15	41	3	9827704
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	FLG2 HNRNPH1 HNRNPH2 ROR2 UBR4 EFTUD2	7.74e-07	272	41	6	31010829
Pubmed	Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma.	COL4A1 COL4A5	1.36e-06	2	41	2	15583824
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	LRP1 USP44 USP2 USP4 PRKCI ADSL USP16 PPM1G EFTUD2	2.07e-06	1005	41	9	19615732
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP44 USP2 USP4 USP16	2.59e-06	81	41	4	12838346
Pubmed	hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization.	HNRNPH1 HNRNPH2	4.06e-06	3	41	2	10456323
Pubmed	Identification of an Altered Matrix Signature in Kidney Aging and Disease.	COL4A1 COL4A5	4.06e-06	3	41	2	34049963
Pubmed	The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen.	COL4A1 COL4A5	4.06e-06	3	41	2	6386565
Pubmed	Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues.	HNRNPH1 HNRNPH2	4.06e-06	3	41	2	14980514
Pubmed	Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.	HNRNPH1 HNRNPH2	4.06e-06	3	41	2	21068389
Pubmed	Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.	HNRNPH1 HNRNPH2	4.06e-06	3	41	2	7499401
Pubmed	Proteomic dissection of the von Hippel-Lindau (VHL) interactome.	COL4A1 COL4A5 HNRNPH1 HNRNPH2	5.54e-06	98	41	4	21942715
Pubmed	Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.	KIF26B ROR2	8.12e-06	4	41	2	28885975
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A1 LRP1 COL4A5 CACHD1 HEG1 ADSL PIEZO1 ROR2 SVIL	8.76e-06	1201	41	9	35696571
Pubmed	The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.	UBR4 EFTUD2	1.35e-05	5	41	2	16247014
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	AKAP13 USP4 ADSL KIF26B HNRNPH1 SVIL UBR4	1.45e-05	689	41	7	36543142
Pubmed	Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.	COL4A1 COL4A5	2.03e-05	6	41	2	10534397
Pubmed	Stimulation of extracellular matrix components in the normal brain by invading glioma cells.	COL4A1 COL4A5	2.03e-05	6	41	2	9506531
Pubmed	HIV-1 gp160 protein-macrophage interactions modulate mesangial cell proliferation and matrix synthesis.	COL4A1 COL4A5	2.03e-05	6	41	2	7495302
Pubmed	A tumor derived motility factor that stimulates cell migration on extracellular matrix.	COL4A1 COL4A5	2.03e-05	6	41	2	9673377
Pubmed	Extracellular matrix of the human optic nerve head.	COL4A1 COL4A5	2.03e-05	6	41	2	2426947
Pubmed	Angiogenesis and collagen type IV expression in different endothelial cell culture systems.	COL4A1 COL4A5	2.03e-05	6	41	2	23551189
Pubmed	Monoclonal antibody to human basement membrane collagen type IV.	COL4A1 COL4A5	2.03e-05	6	41	2	6811420
Pubmed	Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.	COL4A1 COL4A5	2.03e-05	6	41	2	11732842
Pubmed	Developmental distribution of collagen IV isoforms and relevance to ocular diseases.	COL4A1 COL4A5	2.03e-05	6	41	2	19275937
Pubmed	Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.	COL4A1 COL4A5	2.03e-05	6	41	2	6988303
Pubmed	Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.	COL4A1 COL4A5	2.03e-05	6	41	2	6389236
Pubmed	Collagen IV in the developing lens capsule.	COL4A1 COL4A5	2.03e-05	6	41	2	12225806
Pubmed	Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo.	COL4A1 COL4A5	2.84e-05	7	41	2	10639489
Pubmed	Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.	COL4A1 COL4A5	2.84e-05	7	41	2	7521231
Pubmed	Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.	COL4A1 COL4A5	2.84e-05	7	41	2	11711546
Pubmed	Regulation of protease nexin-1 target protease specificity by collagen type IV.	COL4A1 COL4A5	2.84e-05	7	41	2	8006028
Pubmed	Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.	COL4A1 COL4A5	2.84e-05	7	41	2	17418794
Pubmed	A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.	HNRNPH1 HNRNPH2	2.84e-05	7	41	2	31704785
Pubmed	Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.	HNRNPH1 HNRNPH2	2.84e-05	7	41	2	25846207
Pubmed	Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.	LRP1 CREB3	2.84e-05	7	41	2	29547901
Pubmed	Corneal cell proteins and ocular surface pathology.	COL4A1 COL4A5	2.84e-05	7	41	2	10416788
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	COL4A1 COL4A5	2.84e-05	7	41	2	10716744
Pubmed	Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.	COL4A1 COL4A5	2.84e-05	7	41	2	1724753
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	USP2 USP4 ADSL HNRNPH1 UBR4	3.29e-05	313	41	5	16196087
Pubmed	Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.	COL4A1 COL4A5	3.78e-05	8	41	2	10382266
Pubmed	Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.	COL4A1 COL4A5	3.78e-05	8	41	2	3997552
Pubmed	Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.	COL4A1 COL4A5	3.78e-05	8	41	2	29422532
Pubmed	Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.	COL4A1 COL4A5	3.78e-05	8	41	2	10970885
Pubmed	Mice develop normally without tenascin.	COL4A1 COL4A5	3.78e-05	8	41	2	1383086
Pubmed	Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.	COL4A1 COL4A5	3.78e-05	8	41	2	1377218
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	COL4A5 AKAP13 HEG1 KLHL36 PIEZO1 UBR4 CREB3 TMC6	3.81e-05	1105	41	8	35748872
Pubmed	CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).	PPM1G UBR4 EFTUD2	3.82e-05	55	41	3	23178491
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	YTHDC1 HNRNPH1 HNRNPH2 EFTUD2	4.74e-05	169	41	4	23084401
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	LRP1 COL4A5 SPTLC3 WDR27 AKAP13 PRKCI TSC22D1 ROR2 TMC6	4.78e-05	1489	41	9	28611215
Pubmed	Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion.	COL4A1 CLDN10	4.86e-05	9	41	2	34133940
Pubmed	MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?	COL4A1 COL4A5	4.86e-05	9	41	2	9878537
Pubmed	Ror2 is required for midgut elongation during mouse development.	PRKCI ROR2	4.86e-05	9	41	2	20063415
Pubmed	Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.	COL4A1 COL4A5	4.86e-05	9	41	2	8562707
Pubmed	Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.	COL4A1 COL4A5	4.86e-05	9	41	2	12101409
Pubmed	The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.	USP4 USP16	4.86e-05	9	41	2	22195557
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	USP2 USP4 USP16	6.03e-05	64	41	3	33141564
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	COL4A1 COL4A5	6.07e-05	10	41	2	9136074
Pubmed	Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.	COL4A1 COL4A5	6.07e-05	10	41	2	9415455
Pubmed	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.	COL4A1 COL4A5	7.41e-05	11	41	2	14998921
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A1 COL4A5	7.41e-05	11	41	2	7500359
Pubmed	Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.	HNRNPH1 HNRNPH2	7.41e-05	11	41	2	21900255
Pubmed	Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.	COL4A1 COL4A5	7.41e-05	11	41	2	9731539
Pubmed	Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.	KIF26B HNRNPH1 SVIL EFTUD2	8.75e-05	198	41	4	24337577
Pubmed	Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice.	COL4A1 COL4A5	8.88e-05	12	41	2	8918877
Pubmed	Basement membrane fragility underlies embryonic lethality in fukutin-null mice.	COL4A1 COL4A5	8.88e-05	12	41	2	15837576
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A1 COL4A5	8.88e-05	12	41	2	12180907
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	COL4A1 COL4A5	8.88e-05	12	41	2	16024816
Pubmed	A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.	HNRNPH1 HNRNPH2	8.88e-05	12	41	2	37463454
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLG2 YTHDC1 USP16 HNRNPH1 HNRNPH2 PPM1G SVIL EFTUD2	9.40e-05	1257	41	8	36526897
Pubmed	Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.	HNRNPH1 UBR4	1.05e-04	13	41	2	27664236
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	COL4A1 COL4A5	1.05e-04	13	41	2	9833687
Pubmed	Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.	COL4A1 COL4A5	1.22e-04	14	41	2	12878203
Pubmed	Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract.	COL4A1 COL4A5	1.22e-04	14	41	2	19858219
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	COL4A1 COL4A5	1.41e-04	15	41	2	10625553
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	COL4A1 COL4A5	1.41e-04	15	41	2	9264260
Pubmed	Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos.	COL4A1 COL4A5	1.41e-04	15	41	2	10706142
Pubmed	Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.	AKAP13 HNRNPH2 PPM1G EFTUD2	1.46e-04	226	41	4	37839992
Pubmed	Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.	FLG2 HNRNPH1 HNRNPH2	1.61e-04	89	41	3	31267705
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	COL4A1 COL4A5	1.61e-04	16	41	2	15878328
Pubmed	Tandem immunoprecipitation approach to identify HIV-1 Gag associated host factors.	HNRNPH1 HNRNPH2	1.61e-04	16	41	2	24690621
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP2 USP16	1.82e-04	17	41	2	23287719
Pubmed	Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.	USP2 USP4	2.05e-04	18	41	2	30410068
Pubmed	Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.	COL4A1 COL4A5	2.05e-04	18	41	2	9160753
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	AKAP13 ADSL FLG2 HNRNPH1 HNRNPH2 PPM1G UBR4 EFTUD2	2.12e-04	1415	41	8	28515276
Pubmed	Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.	COL4A1 COL4A5	2.29e-04	19	41	2	15689378
Pubmed	The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.	COL4A1 COL4A5	2.81e-04	21	41	2	23325811
Pubmed	Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.	PRKCI KIF26B	2.81e-04	21	41	2	25168025
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	HNRNPH1 HNRNPH2 EFTUD2	2.93e-04	109	41	3	12226669
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	AKAP13 PRKCI USP16 PIEZO1 ROR2 PPM1G UBR4 EFTUD2	2.97e-04	1487	41	8	33957083
Pubmed	MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.	COL4A1 ROR2	3.09e-04	22	41	2	34032267
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	HNRNPH1 HNRNPH2	3.09e-04	22	41	2	18377426
Pubmed	Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.	USP44 USP4	3.09e-04	22	41	2	26811477
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	COL4A5 USP4 PRKCI TSC22D1 PPM1G UBR4 EFTUD2	3.11e-04	1124	41	7	21900206
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	FLG2 PPM1G UBR4 EFTUD2	3.34e-04	281	41	4	26725010
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	ABL2 YTHDC1	4.00e-04	25	41	2	35874829
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	COL4A1 COL4A5	4.33e-04	26	41	2	24742657
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AKAP13 PRKCI ABL2 KIF26B ROR2 SVIL	4.86e-04	861	41	6	36931259
Pubmed	Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.	USP2 USP4	5.03e-04	28	41	2	22118674
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	USP4 ADSL HNRNPH1 HNRNPH2 EFTUD2	5.14e-04	565	41	5	33567341
Interaction	PLOD1 interactions	COL4A1 COL4A5 USP4 PTPRU HNRNPH1 HNRNPH2 EFTUD2	1.54e-06	292	40	7	int:PLOD1
Interaction	CD82 interactions	LRP1 BCL3 HNRNPH1 CREB3	6.40e-06	61	40	4	int:CD82
Interaction	DUSP5P1 interactions	YTHDC1 HNRNPH1	1.15e-05	3	40	2	int:DUSP5P1
Interaction	LARP7 interactions	USP4 TSC22D1 RBMXL3 FLG2 YTHDC1 HNRNPH1 HNRNPH2 PPM1G UBR4 EFTUD2	4.70e-05	1113	40	10	int:LARP7
Interaction	KLF7 interactions	YTHDC1 HNRNPH1	5.73e-05	6	40	2	int:KLF7
Interaction	PGGHG interactions	YTHDC1 HNRNPH1	5.73e-05	6	40	2	int:PGGHG
Cytoband	Xq22	COL4A5 HNRNPH2	1.78e-04	22	41	2	Xq22
Cytoband	21q22.11	USP16 IFNAR2	1.42e-03	62	41	2	21q22.11
GeneFamily	Ubiquitin specific peptidases	USP44 USP2 USP4 USP16	2.13e-06	56	30	4	366
GeneFamily	Collagens	COL4A1 COL4A5	2.63e-03	46	30	2	490
GeneFamily	RNA binding motif containing	RBMXL3 HNRNPH1 HNRNPH2	5.18e-03	213	30	3	725
ToppCell	droplet-Kidney-KIDNEY-1m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 COL4A5 USP2 TSC22D1 CLDN10	9.35e-07	194	41	5	837cee7e6147d92a2f4b86f1ed761a9bfe65b61d
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	AKAP13 CACHD1 ABL2 RFX2 SVIL	1.03e-06	198	41	5	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	AT1-AT2_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	USP44 SPTLC3 HEG1 PTPRU	9.55e-06	145	41	4	cd5de30fd948024e3ad043c9411ce9f2722178b2
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	WDR27 ABL2 PIEZO1 UBR4	1.24e-05	155	41	4	15bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	USP44 AKAP13 PRKCI CACHD1	1.51e-05	163	41	4	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	COL4A1 COL4A5 HEG1 RAI2	2.38e-05	183	41	4	6821dca076318115d360ff426eb1218cfe104063
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP1 CACHD1 PTPRU RAI2	2.54e-05	186	41	4	f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	COL4A1 COL4A5 ZIC5 SVIL	2.71e-05	189	41	4	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 HEG1 KMT2E HNRNPH1	2.76e-05	190	41	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 SPTLC3 PRKCI SVIL	2.82e-05	191	41	4	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 SPTLC3 PRKCI SVIL	2.82e-05	191	41	4	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A1 LRP1 KIF26B ROR2	2.88e-05	192	41	4	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 AKAP13 RFX2 SVIL	2.88e-05	192	41	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A1 LRP1 KIF26B ROR2	2.88e-05	192	41	4	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A1 LRP1 KIF26B ROR2	2.88e-05	192	41	4	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A1 USP2 RAI2 ROR2	2.94e-05	193	41	4	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A5 USP2 TSC22D1 CLDN10	3.12e-05	196	41	4	d74e899cc120146dded3a20716e22c7aca4f074a
ToppCell	(4)_Endothelial_cells-(41)_EC-arteriolar\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	COL4A1 AKAP13 TSC22D1 HEG1	3.18e-05	197	41	4	482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A1 TSC22D1 HEG1 ZIC5	3.18e-05	197	41	4	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	BCL3 KMT2E YTHDC1 USP16	3.18e-05	197	41	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A1 TSC22D1 HEG1 SMIM10	3.24e-05	198	41	4	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	BCL3 KMT2E YTHDC1 USP16	3.24e-05	198	41	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BCL3 KMT2E YTHDC1 USP16	3.24e-05	198	41	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 LRP1 COL4A5 HEG1	3.24e-05	198	41	4	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	COL4A1 COL4A5 KIF26B ROR2	3.31e-05	199	41	4	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL4A1 AKAP13 TSC22D1 HEG1	3.37e-05	200	41	4	46dac23d8f9d426fe52ad6dac9c15ce91e615762
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AKAP13 ABL2 UBR4 TMC6	3.37e-05	200	41	4	74ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A1 ABL2 SMIM10 ROR2	3.37e-05	200	41	4	410b1a31de21c57d87ca2104f61cf4a7d4dd2f30
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LRP1 USP2 PRKCI ROR2	3.37e-05	200	41	4	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL4A5 ABL2 ROR2	1.13e-04	102	41	3	0bbc6344d0baee47326a16a89773bb5c68a7b040
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL4A5 ABL2 ROR2	1.13e-04	102	41	3	11fbdb428824023603e9d4ee41e957ba84e7c29e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related-Oligodendrocyte/OPC\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	KIF26B SMIM10 SVIL	3.01e-04	142	41	3	43e72e4b9ae33768672ef90c8bbfd2ca1818c746
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	KIF26B SMIM10 SVIL	3.01e-04	142	41	3	d2d150e3019a5b7b143e50b1c1c2b6764abf36bf
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A1 COL4A5 KIF26B	3.01e-04	142	41	3	7b6678a73d04feac12bbc909f2df478215511de0
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A1 COL4A5 KIF26B	3.01e-04	142	41	3	347f5832a86f4e41752e36e3e737df7ca6f79e90
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	USP44 ROR2 EFTUD2	3.19e-04	145	41	3	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 COL4A5 CLDN10	3.81e-04	154	41	3	5ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 FLG2 ROR2	3.88e-04	155	41	3	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	USP44 AKAP13 PRKCI	4.03e-04	157	41	3	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	COL4A5 ABL2 ROR2	4.18e-04	159	41	3	92049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	COL4A1 COL4A5 SVIL	4.50e-04	163	41	3	1e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SPTLC3 AKAP13 ABL2	4.50e-04	163	41	3	a6e272e043859858084b8d4d96fa4ff9e6eca454
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A5 KIF26B ROR2	4.58e-04	164	41	3	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	Multiple_Sclerosis-Other-HSPC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	TSC22D1 CLDN10 SMIM10	4.58e-04	164	41	3	6af5529507d695b347adee4be5ead70f56c9cf55
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL4A5 ABL2 ROR2	4.66e-04	165	41	3	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL4A5 ABL2 ROR2	4.66e-04	165	41	3	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	SPTLC3 TSC22D1 CLDN10	4.66e-04	165	41	3	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSC22D1 CACHD1 HEG1	4.83e-04	167	41	3	f01b96173deda0239fa482989873cf308e49d48c
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSC22D1 CACHD1 HEG1	4.83e-04	167	41	3	5fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCell	Control-NK\|Control / Disease group and Cell class	CACHD1 ABL2 SMIM10	4.91e-04	168	41	3	683d389c8a1e791bfc773e63148115a21a6566db
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 HEG1 PTPRU	4.91e-04	168	41	3	3bddf411a60137a8883fc9e77586e4719b0d6067
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL4A5 ABL2 ZIC5	4.91e-04	168	41	3	9930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 HEG1 PTPRU	4.91e-04	168	41	3	b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SLC35G1 RFX2	4.91e-04	168	41	3	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	droplet-Heart-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 COL4A5 SVIL	5.00e-04	169	41	3	2e5bb6437bc9c614e337c5ffb6f6457cd9fc7f4c
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	COL4A1 HEG1 RFX2	5.08e-04	170	41	3	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A5 TSC22D1 CLDN10	5.08e-04	170	41	3	ce79f5d0d475fcb6c5a61c94938c65210b3c59d9
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL4A5 ABL2 ZIC5	5.17e-04	171	41	3	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL4A5 ABL2 ZIC5	5.17e-04	171	41	3	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A1 COL4A5 SVIL	5.35e-04	173	41	3	f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	SLC35G1 CLDN10 IFNAR2	5.44e-04	174	41	3	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	Adult-Epithelial-basal_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL4A5 CACHD1 CLDN10	5.44e-04	174	41	3	a4f98afe7d1cc2617f6f7bc8092c41df57474b30
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	COL4A1 HEG1 ZIC5	5.44e-04	174	41	3	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-31\|World / Primary Cells by Cluster	TSC22D1 KIF26B HNRNPH1	5.53e-04	175	41	3	491508bf9e8a09b057d5711cc23dd91324e6a806
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 LRP1 ROR2	5.62e-04	176	41	3	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 LRP1 ROR2	5.62e-04	176	41	3	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A5 CACHD1 PTPRU	5.72e-04	177	41	3	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A1 COL4A5 SVIL	5.72e-04	177	41	3	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A1 HEG1 ROR2	5.72e-04	177	41	3	b75f519d72611b293d9684f7dcfb1b70fbf54a90
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A5 CACHD1 PTPRU	5.72e-04	177	41	3	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	LRP1 HEG1 KIF26B	5.81e-04	178	41	3	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A5 TSC22D1 SVIL	5.81e-04	178	41	3	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A5 TSC22D1 SVIL	5.81e-04	178	41	3	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP1 SVIL TMC6	5.81e-04	178	41	3	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	COL4A5 CACHD1 CLDN10	5.91e-04	179	41	3	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A1 HEG1 SVIL	5.91e-04	179	41	3	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL4A1 BCL3 KIF26B	6.00e-04	180	41	3	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TSC22D1 CLDN10 SMIM10	6.00e-04	180	41	3	f598bb9df0d784120847fada2d9a2a88b8b68cd1
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TSC22D1 CLDN10 SMIM10	6.00e-04	180	41	3	b4fa047f271c7b56940bdc85c912f50aa5b5ca82
ToppCell	IIH-plasma\|IIH / Condition, Cell_class and T cell subcluster	TSC22D1 PTPRU RAI2	6.10e-04	181	41	3	13d1f31bcbac21aea91de74f51eed549ec61003e
ToppCell	IIH-plasma-\|IIH / Condition, Cell_class and T cell subcluster	TSC22D1 PTPRU RAI2	6.10e-04	181	41	3	140ac43dc6b89396872f908c14c89278f6d982b2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 KIF26B ROR2	6.10e-04	181	41	3	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 PRKCI KIF26B	6.10e-04	181	41	3	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 PRKCI KIF26B	6.10e-04	181	41	3	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	6497eeafb2b137e70261ec0314782831892a940d
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	COL4A5 CACHD1 PTPRU	6.20e-04	182	41	3	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	Control-Hematopoietic_SC-HSPC\|Control / Disease group, lineage and cell class	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	14e347c0e6444410f1948851407bb18c706569f4
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	COL4A1 HEG1 RAI2	6.20e-04	182	41	3	d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell	Control-Hematopoietic_SC\|Control / Disease group, lineage and cell class	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	43243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	COL4A5 CACHD1 PTPRU	6.20e-04	182	41	3	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	bd1626261803324084fafca2f6665b50854e7fae
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A5 CACHD1 KIF26B	6.20e-04	182	41	3	3fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TSC22D1 CLDN10 SMIM10	6.20e-04	182	41	3	0d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	COL4A5 CACHD1 CLDN10	6.30e-04	183	41	3	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	COVID-19_Severe-Hematopoietic_SC-HSPC\|COVID-19_Severe / Disease group, lineage and cell class	SPTLC3 CLDN10 SMIM10	6.30e-04	183	41	3	4146b1c0e5f76d25226745abfa28f77127a444fc
ToppCell	COVID-19_Severe-Hematopoietic_SC\|COVID-19_Severe / Disease group, lineage and cell class	SPTLC3 CLDN10 SMIM10	6.30e-04	183	41	3	92aab7ce65aca17988bc2add4ff9fb8384e2c21b
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP1 SPTLC3 ROR2	6.30e-04	183	41	3	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
Disease	Hematuria	COL4A1 COL4A5	6.09e-05	9	39	2	C0018965
Disease	collagen disease (implicated_via_orthology)	COL4A1 COL4A5	1.11e-04	12	39	2	DOID:854 (implicated_via_orthology)
Disease	Migraine Disorders	COL4A1 LRP1	1.32e-04	13	39	2	C0149931
Disease	migraine disorder, pulse pressure measurement	COL4A1 LRP1	5.42e-04	26	39	2	EFO_0005763, MONDO_0005277
Disease	spontaneous coronary artery dissection	COL4A1 LRP1	7.73e-04	31	39	2	EFO_0010820
Disease	Focal glomerulosclerosis	COL4A1 COL4A5	1.04e-03	36	39	2	C0017668
Disease	hepatitis B (is_implicated_in)	EFTUD2 IFNAR2	1.10e-03	37	39	2	DOID:2043 (is_implicated_in)
Disease	migraine disorder	COL4A1 LRP1 KIF26B SVIL	1.24e-03	357	39	4	MONDO_0005277
Disease	fibromuscular dysplasia	LRP1 SVIL	1.55e-03	44	39	2	EFO_1000938
Disease	diastolic blood pressure, systolic blood pressure	COL4A1 LRP1 KMT2E ZIC5 SVIL	1.81e-03	670	39	5	EFO_0006335, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRLMTGDTYTAHAGA	ABL2	431	P42684
FYSHGMGAEGRESES	AKAP13	1511	Q12802
WGRSGTESDHGYSTM	CACHD1	1186	Q5VU97
GATSVMSSRTKYHGG	CLDN10	196	P78369
YSFVMHTSAGAEGSG	COL4A1	1581	P02462
YDSGASVDSSGHTVM	RAI2	361	Q9Y5P3
TGRRGSGHSEYSDSE	FLG2	1721	Q5D862
HSMCSLGDSIYSIGG	KLHL36	486	Q8N4N3
DSSTMSHTVAGGGSG	PRKCI	6	P41743
YMGGHGSRHSLASTD	LRP1	4511	Q07954
HSGGSSGYESVMRDS	KIF26B	1891	Q2KJY2
MSDHRYGDGGSSFQS	HNRNPH2	271	P55795
SQLDSTHSGRGTMYS	KMT2E	1051	Q8IZD2
GGSHTALGDRSYSES	HEG1	496	Q9ULI3
MSDHRYGDGGSTFQS	HNRNPH1	271	P31943
TEAAPRTSGGGYTMH	IFNAR2	326	P48551
FMDTHGYSTRGDQRS	PTPRU	826	Q92729
GYSFMMHTSAGAEGS	COL4A5	1596	P29400
MYSGSSALHSASGRG	BCL3	306	P20749
MYSSDTRGSLPAEHG	CREB3	246	O43889
GVHGDSPYGSGTMDT	SVIL	81	O95425
SPYGSGTMDTHSLES	SVIL	86	O95425
SSAGAYLIHGGMDST	RFX2	146	P48378
SETAMFSVYDGHGGE	PPM1G	51	O15355
MAAGGDHGSPDSYRS	ADSL	1	P30566
YGTGVASTRHEMGTL	SPTLC3	191	Q9NUV7
GMDYRGTASTTKSGH	ROR2	321	Q01974
TLSHYTESVGSGEMG	TSC22D1	476	Q15714
MHSSGVSRGGSGFSA	USP4	271	Q13107
GVVEHSGTMRSGHYT	USP16	746	Q9Y5T5
GRSDDAYSGGHDSSS	RBMXL3	446	Q8N7X1
SEEYGSDHETGSSGS	YTHDC1	176	Q96MU7
SGHYVGGSIRSMAAA	SMIM10	6	Q96HG1
TSGMEESYSGHLKGT	SLC35G1	211	Q2M3R5
SMAHSFGESYRVGST	TMC6	361	Q7Z403
DMGSPLSTGYHTRSG	PIEZO1	1606	Q92508
VYEMGSSTFSHRLAG	WDR27	781	A2RRH5
HTYTGGVDSDLGEAM	EFTUD2	451	Q15029
VSNHSGTTMGGHYTA	USP2	546	O75604
AGEHSVSGRSSAYGD	UBR4	2906	Q5T4S7
RSMGTGDDSYFLHDG	USP44	121	Q9H0E7
HSAGMFISASGTYAG	ZIC5	236	Q96T25