Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	semaphorin receptor activity	MET PLXNB1 PLXNB3	1.54e-05	12	84	3	GO:0017154
GeneOntologyCellularComponent	extracellular matrix	TINAGL1 VTN MATN1 LAMA5 RTN4RL1 CPZ MMP1 MMP3 MMP20 FREM3 CTSL ITIH5	1.34e-05	656	85	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	TINAGL1 VTN MATN1 LAMA5 RTN4RL1 CPZ MMP1 MMP3 MMP20 FREM3 CTSL ITIH5	1.38e-05	658	85	12	GO:0030312
GeneOntologyCellularComponent	membrane attack complex	C5 C8B	3.39e-04	7	85	2	GO:0005579
Domain	Spin-Ssty	SPIN2A SPIN2B SPIN3	8.72e-07	5	84	3	PF02513
Domain	SPIN/Ssty	SPIN2A SPIN2B SPIN3	8.72e-07	5	84	3	IPR003671
Domain	Hemopexin-like_dom	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	IPR000585
Domain	Hemopexin-like_repeat	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	IPR018487
Domain	Hemopexin	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	PF00045
Domain	HEMOPEXIN	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	PS00024
Domain	-	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	2.110.10.10
Domain	HEMOPEXIN_2	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	PS51642
Domain	HX	VTN MMP1 MMP3 MMP20	3.16e-06	23	84	4	SM00120
Domain	SPIN-2	SPIN2A SPIN2B	2.00e-05	2	84	2	IPR029564
Domain	Pept_M10A_Zn_BS	MMP1 MMP3 MMP20	3.84e-05	15	84	3	IPR021158
Domain	Hemopexin_CS	VTN MMP1 MMP3	5.70e-05	17	84	3	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP1 MMP3 MMP20	6.82e-05	18	84	3	IPR016293
Domain	PG_binding_1	MMP1 MMP3 MMP20	9.47e-05	20	84	3	PF01471
Domain	Peptidoglycan-bd-like	MMP1 MMP3 MMP20	9.47e-05	20	84	3	IPR002477
Domain	M10A_MMP	MMP1 MMP3 MMP20	1.46e-04	23	84	3	IPR033739
Domain	Pept_M10A	MMP1 MMP3 MMP20	1.46e-04	23	84	3	IPR021190
Domain	Peptidase_M10	MMP1 MMP3 MMP20	1.66e-04	24	84	3	PF00413
Domain	IPT	MET PLXNB1 PLXNB3	2.37e-04	27	84	3	SM00429
Domain	ZnMc	MMP1 MMP3 MMP20	2.95e-04	29	84	3	SM00235
Domain	Peptidase_Metallo	MMP1 MMP3 MMP20	2.95e-04	29	84	3	IPR006026
Domain	TIG	MET PLXNB1 PLXNB3	3.60e-04	31	84	3	PF01833
Domain	Sema	MET PLXNB1 PLXNB3	3.60e-04	31	84	3	SM00630
Domain	Semap_dom	MET PLXNB1 PLXNB3	3.60e-04	31	84	3	IPR001627
Domain	Sema	MET PLXNB1 PLXNB3	3.60e-04	31	84	3	PF01403
Domain	SEMA	MET PLXNB1 PLXNB3	3.60e-04	31	84	3	PS51004
Domain	PSI	MET PLXNB1 PLXNB3	3.96e-04	32	84	3	PF01437
Domain	IPT	MET PLXNB1 PLXNB3	3.96e-04	32	84	3	IPR002909
Domain	Plexin_repeat	MET PLXNB1 PLXNB3	3.96e-04	32	84	3	IPR002165
Domain	SO	TINAGL1 VTN	7.05e-04	9	84	2	SM00201
Domain	Plexin_cytopl	PLXNB1 PLXNB3	7.05e-04	9	84	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB1 PLXNB3	7.05e-04	9	84	2	IPR013548
Domain	Plexin	PLXNB1 PLXNB3	7.05e-04	9	84	2	IPR031148
Domain	CYSTEINE_SWITCH	MMP1 MMP3 MMP20	8.27e-04	41	84	3	PS00546
Domain	Somatomedin_B_dom	TINAGL1 VTN	8.79e-04	10	84	2	IPR001212
Domain	SMB_1	TINAGL1 VTN	8.79e-04	10	84	2	PS00524
Domain	SMB_2	TINAGL1 VTN	8.79e-04	10	84	2	PS50958
Domain	Pept_M10_metallopeptidase	MMP1 MMP3 MMP20	9.51e-04	43	84	3	IPR001818
Domain	PSI	MET PLXNB1 PLXNB3	1.02e-03	44	84	3	IPR016201
Domain	Pept_his_AS	TINAGL1 CTSL	1.07e-03	11	84	2	IPR025660
Domain	PSI	MET PLXNB1 PLXNB3	1.16e-03	46	84	3	SM00423
Domain	Pept_C1	TINAGL1 CTSL	1.51e-03	13	84	2	SM00645
Domain	Peptidase_C1A_C	TINAGL1 CTSL	1.51e-03	13	84	2	IPR000668
Domain	Peptidase_C1	TINAGL1 CTSL	1.51e-03	13	84	2	PF00112
Domain	Peptidase_C1A	TINAGL1 CTSL	1.51e-03	13	84	2	IPR013128
Domain	Gelsolin	FLII SEC23A	1.76e-03	14	84	2	PF00626
Domain	Gelsolin-like_dom	FLII SEC23A	1.76e-03	14	84	2	IPR007123
Domain	Integrin_alpha_C_CS	ITGA8 ITGA9	2.30e-03	16	84	2	IPR018184
Domain	NAP	SET SETSIP	2.60e-03	17	84	2	PF00956
Domain	NAP_family	SET SETSIP	2.60e-03	17	84	2	IPR002164
Domain	Integrin_alpha-2	ITGA8 ITGA9	2.92e-03	18	84	2	IPR013649
Domain	Integrin_alpha2	ITGA8 ITGA9	2.92e-03	18	84	2	PF08441
Domain	Integrin_alpha	ITGA8 ITGA9	2.92e-03	18	84	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA8 ITGA9	2.92e-03	18	84	2	PS00242
Domain	Int_alpha_beta-p	ITGA8 ITGA9	3.25e-03	19	84	2	IPR013519
Domain	Int_alpha	ITGA8 ITGA9	3.25e-03	19	84	2	SM00191
Domain	FG_GAP	ITGA8 ITGA9	4.36e-03	22	84	2	PS51470
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	VTN MATN1 ITGA8 LAMA5 MMP1 MMP3 ITGA9 MMP20 CTSL	1.01e-05	300	66	9	M610
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	VTN MATN1 ITGA8 MMP1 MMP3 ITGA9 MMP20 CTSL	2.59e-05	258	66	8	MM14572
Pathway	REACTOME_ECM_PROTEOGLYCANS	VTN MATN1 ITGA8 LAMA5 ITGA9	2.76e-05	76	66	5	M27219
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP1 MMP3 MMP20 NOS2	6.17e-05	46	66	4	M46450
Pathway	REACTOME_ECM_PROTEOGLYCANS	VTN MATN1 ITGA8 ITGA9	6.72e-05	47	66	4	MM14925
Pathway	REACTOME_COLLAGEN_DEGRADATION	MMP1 MMP3 MMP20 CTSL	1.08e-04	53	66	4	MM14566
Pathway	REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING	TYK2 LAMA5 MMP1 MMP3 NOS2	1.69e-04	111	66	5	M27609
Pathway	REACTOME_COLLAGEN_DEGRADATION	MMP1 MMP3 MMP20 CTSL	2.25e-04	64	66	4	M26953
Pathway	PID_INTEGRIN1_PATHWAY	VTN ITGA8 LAMA5 ITGA9	2.54e-04	66	66	4	M18
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP1 MMP3 MMP20	3.28e-04	29	66	3	MM15981
Pathway	WP_FOCAL_ADHESION	MET VTN PIK3R3 ITGA8 LAMA5 ITGA9	3.30e-04	199	66	6	M39402
Pathway	KEGG_FOCAL_ADHESION	MET VTN PIK3R3 ITGA8 LAMA5 ITGA9	3.30e-04	199	66	6	M7253
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP1 MMP3 MMP20	3.64e-04	30	66	3	M39652
Pathway	WP_ANTIVIRAL_AND_ANTIINFLAMMATORY_EFFECTS_OF_NRF2_ON_SARSCOV2_PATHWAY	GUCY1A1 MMP1 MMP3	4.41e-04	32	66	3	M42560
Pathway	KEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION	C5 C8B	4.47e-04	7	66	2	M47873
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	LAMA5 MMP1 MMP3 MMP20 CTSL	4.94e-04	140	66	5	M587
Pathway	REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION	MET PLXNB1	5.94e-04	8	66	2	M27325
Pathway	REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION	MET PLXNB1	5.94e-04	8	66	2	MM15045
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C5 C8B	5.94e-04	8	66	2	MM14656
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C5 C8B	5.94e-04	8	66	2	M27006
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	VTN ITGA8 LAMA5 ITGA9	6.38e-04	84	66	4	M7098
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	MMP1 MMP3 CTSL	7.36e-04	38	66	3	MM14611
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_MAC_INHIBITION	VTN C8B	7.61e-04	9	66	2	M47881
Pathway	KEGG_PATHWAYS_IN_CANCER	MET PIK3R3 LAMA5 MMP1 BCR NOS2 HDAC1	7.87e-04	325	66	7	M12868
Pubmed	Plexin-B3 is a functional receptor for semaphorin 5A.	MET PLXNB1 PLXNB3	1.40e-07	5	85	3	15218527
Pubmed	Interplay between scatter factor receptors and B plexins controls invasive growth.	MET PLXNB1 PLXNB3	1.40e-07	5	85	3	15184888
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN2A SPIN2B SPIN3	2.80e-07	6	85	3	29061846
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP1 MMP3 MMP20	4.90e-07	7	85	3	8921407
Pubmed	Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).	MMP1 MMP3 MMP20	4.90e-07	7	85	3	10922468
Pubmed	HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.	MET MMP1 MMP3	7.82e-07	8	85	3	23934123
Pubmed	No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.	MMP1 MMP3	5.90e-06	2	85	2	19318431
Pubmed	Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis.	MMP1 MMP3	5.90e-06	2	85	2	21357403
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis.	MMP1 MMP3	5.90e-06	2	85	2	12364729
Pubmed	[Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis].	MMP1 MMP3	5.90e-06	2	85	2	16202315
Pubmed	Effects of melittin on the production of matrix metalloproteinase-1 and -3 in rheumatoid arthritic fibroblast-like synoviocytes.	MMP1 MMP3	5.90e-06	2	85	2	18212480
Pubmed	No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese.	MMP1 MMP3	5.90e-06	2	85	2	16937230
Pubmed	[MMP-1 and MMP-3 gene encoding polymorphism and the risk of the development of pelvic organ prolapse and stress urinary incontinence].	MMP1 MMP3	5.90e-06	2	85	2	20873121
Pubmed	Human cytomegalovirus induces MMP-1 and MMP-3 expression in aortic smooth muscle cells.	MMP1 MMP3	5.90e-06	2	85	2	22207289
Pubmed	Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients.	MMP1 MMP3	5.90e-06	2	85	2	21345293
Pubmed	MMP-1 and -3 haplotype is associated with congenital anomalies of the kidney and urinary tract.	MMP1 MMP3	5.90e-06	2	85	2	24414606
Pubmed	Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level.	MMP1 MMP3	5.90e-06	2	85	2	25291965
Pubmed	Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients.	MMP1 MMP3	5.90e-06	2	85	2	15288468
Pubmed	A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility.	MMP1 MMP3	5.90e-06	2	85	2	12473595
Pubmed	MMP1 and MMP3 gene polymorphisms in patients with acute coronary syndromes.	MMP1 MMP3	5.90e-06	2	85	2	29044936
Pubmed	MMP gene polymorphisms as contributors for cleft lip/palate: association with MMP3 but not MMP1.	MMP1 MMP3	5.90e-06	2	85	2	17537400
Pubmed	Polymorphism of MMP1 and MMP3 promoter regions and HR-HPV infection in women from Burkina Faso and Côte d'Ivoire.	MMP1 MMP3	5.90e-06	2	85	2	32417757
Pubmed	MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation.	MMP1 MMP3	5.90e-06	2	85	2	20935575
Pubmed	Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.	VTN LAMA5	5.90e-06	2	85	2	34605523
Pubmed	Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation.	MMP1 MMP3	5.90e-06	2	85	2	19906289
Pubmed	In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.	MMP1 MMP3	5.90e-06	2	85	2	23978194
Pubmed	Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population.	MMP1 MMP3	5.90e-06	2	85	2	16899023
Pubmed	Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China.	MMP1 MMP3	5.90e-06	2	85	2	15528217
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients.	MMP1 MMP3	5.90e-06	2	85	2	19221176
Pubmed	Investigation of the relationship between MMP-1 (- 1607 1G/2G), MMP-3 (- 1171 5A/6A) gene variations and development of bladder cancer.	MMP1 MMP3	5.90e-06	2	85	2	34693500
Pubmed	The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein.	ERCC3 BCR	5.90e-06	2	85	2	9874796
Pubmed	Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma.	MMP1 MMP3	5.90e-06	2	85	2	15274394
Pubmed	Association of MMP-1 (rs1799750)-1607 2G/2G and MMP-3 (rs3025058)-1612 6A/6A Genotypes With Coronary Artery Disease Risk Among Iranian Turks.	MMP1 MMP3	5.90e-06	2	85	2	31356534
Pubmed	Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear.	MMP1 MMP3	5.90e-06	2	85	2	28160256
Pubmed	Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis.	MMP1 MMP3	5.90e-06	2	85	2	25854159
Pubmed	Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.	MMP1 MMP3	5.90e-06	2	85	2	15383690
Pubmed	Genetic Dimension of Intervertebral Disc Degeneration: Polymorphism of Matrix Metalloproteinase 1 and 3 in the North Iranian Population.	MMP1 MMP3	5.90e-06	2	85	2	28497435
Pubmed	MMP1 and MMP20 contribute to tooth agenesis in humans.	MMP1 MMP20	5.90e-06	2	85	2	21144496
Pubmed	Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.	MMP1 MMP3	5.90e-06	2	85	2	15319295
Pubmed	Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.	MMP1 MMP3	5.90e-06	2	85	2	12054564
Pubmed	The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.	MMP1 MMP3	5.90e-06	2	85	2	17919326
Pubmed	Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients.	MMP1 MMP3	5.90e-06	2	85	2	17765638
Pubmed	Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation.	MMP1 MMP3	5.90e-06	2	85	2	16972994
Pubmed	Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.	MET ICA1	5.90e-06	2	85	2	8326004
Pubmed	Variation of matrix metalloproteinase 1 and 3 haplotypes and their serum levels in patients with rheumatoid arthritis and osteoarthritis.	MMP1 MMP3	5.90e-06	2	85	2	21770773
Pubmed	The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse.	MMP1 MMP3	5.90e-06	2	85	2	23108733
Pubmed	Increased production of matrix metalloproteinases 1 and 3 by smooth muscle cells upon infection with Chlamydia pneumoniae.	MMP1 MMP3	5.90e-06	2	85	2	13129650
Pubmed	Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.	MET PLXNB1	5.90e-06	2	85	2	19940359
Pubmed	Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear.	MMP1 MMP3	5.90e-06	2	85	2	31652448
Pubmed	Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progression.	MMP1 MMP3	5.90e-06	2	85	2	17145822
Pubmed	Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.	MMP1 MMP3	5.90e-06	2	85	2	26510114
Pubmed	Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies.	MMP1 MMP3	5.90e-06	2	85	2	19843588
Pubmed	Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs.	MMP1 MMP3	5.90e-06	2	85	2	23934131
Pubmed	Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development.	MMP1 MMP3	5.90e-06	2	85	2	34445715
Pubmed	Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.	MMP1 MMP3	5.90e-06	2	85	2	12071839
Pubmed	Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.	MMP1 MMP3	5.90e-06	2	85	2	28002595
Pubmed	Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle.	MMP1 MMP3	5.90e-06	2	85	2	35912721
Pubmed	Epigallocatechin-3-gallate suppresses TNF-alpha -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts.	MMP1 MMP3	5.90e-06	2	85	2	18496696
Pubmed	[Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer].	MMP1 MMP3	5.90e-06	2	85	2	19432148
Pubmed	Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.	MMP1 MMP3	5.90e-06	2	85	2	20038976
Pubmed	Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.	MMP1 MMP3	5.90e-06	2	85	2	12432557
Pubmed	Comparison of human stromelysin and collagenase by cloning and sequence analysis.	MMP1 MMP3	5.90e-06	2	85	2	3030290
Pubmed	Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins.	MMP1 MMP3	5.90e-06	2	85	2	19508478
Pubmed	Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer.	MMP1 MMP3	5.90e-06	2	85	2	33170424
Pubmed	Enhanced cell cycle entry and mitogen-activated protein kinase-signaling and downregulation of matrix metalloproteinase-1 and -3 in human diabetic arterial vasculature.	MMP1 MMP3	5.90e-06	2	85	2	17316652
Pubmed	Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met.	MET PLXNB1	5.90e-06	2	85	2	20164843
Pubmed	Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.	MMP1 MMP3	5.90e-06	2	85	2	21753786
Pubmed	Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype.	MMP1 MMP3	5.90e-06	2	85	2	27793533
Pubmed	The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China.	MMP1 MMP3	5.90e-06	2	85	2	15879464
Pubmed	Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.	SPIN2A SPIN2B	5.90e-06	2	85	2	12145692
Pubmed	Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.	MMP1 MMP3	5.90e-06	2	85	2	15194213
Pubmed	[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer].	MMP1 MMP3	5.90e-06	2	85	2	16080875
Pubmed	Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis.	MMP1 MMP3	5.90e-06	2	85	2	16532917
Pubmed	USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET.	MET USP8	5.90e-06	2	85	2	25744385
Pubmed	Coeliac disease candidate genes: no association with functional polymorphisms in matrix metalloproteinase 1 and 3 gene promoters.	MMP1 MMP3	5.90e-06	2	85	2	12229968
Pubmed	Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.	MMP1 MMP3	5.90e-06	2	85	2	15701845
Pubmed	Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation.	MMP1 MMP3	5.90e-06	2	85	2	27706715
Pubmed	Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target.	MMP1 MMP3	5.90e-06	2	85	2	12784383
Pubmed	Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.	MMP1 MMP3	5.90e-06	2	85	2	15312099
Pubmed	Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND.	MMP1 MMP3	5.90e-06	2	85	2	29358561
Pubmed	MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA).	MMP1 MMP3	5.90e-06	2	85	2	25599395
Pubmed	Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization.	MMP1 MMP3	5.90e-06	2	85	2	12060661
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP1 MMP3 MMP20	7.71e-06	16	85	3	20484597
Pubmed	Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.	TINAGL1 MMP1 CTSL	1.33e-05	19	85	3	22987638
Pubmed	Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.	MMP1 MMP3	1.77e-05	3	85	2	17669621
Pubmed	Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease.	MMP1 MMP3	1.77e-05	3	85	2	17077200
Pubmed	Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.	MET NOS2	1.77e-05	3	85	2	29045907
Pubmed	Association Between Matrix Metalloproteinase-1, 2, 3 Polymorphisms and Oral Cancer Risk: A Meta-Analysis.	MMP1 MMP3	1.77e-05	3	85	2	30117779
Pubmed	Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals. Role of calcium-dependent protein kinase C alpha.	MMP1 MMP3	1.77e-05	3	85	2	11836255
Pubmed	Extracellular β-NAD(+) inhibits interleukin-1-induced matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts.	MMP1 MMP3	1.77e-05	3	85	2	23509928
Pubmed	Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.	MMP1 MMP3	1.77e-05	3	85	2	18619594
Pubmed	Variations in matrix metalloproteinase-1, -3, and -9 genes and the risk of acute coronary syndrome and coronary artery disease in the Chinese Han population.	MMP1 MMP3	1.77e-05	3	85	2	23377317
Pubmed	Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.	MMP1 MMP3	1.77e-05	3	85	2	16311244
Pubmed	Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.	MMP1 MMP3	1.77e-05	3	85	2	21707906
Pubmed	Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.	MMP1 MMP3	1.77e-05	3	85	2	19321798
Pubmed	Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes.	MMP1 MMP3	1.77e-05	3	85	2	22776467
Pubmed	The association of MMP-1, -3 and -9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients.	MMP1 MMP3	1.77e-05	3	85	2	18426080
Pubmed	Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis.	MMP1 MMP3	1.77e-05	3	85	2	15142265
Pubmed	Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.	MMP1 MMP3	1.77e-05	3	85	2	20609440
Pubmed	Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China.	MMP1 MMP3	1.77e-05	3	85	2	17502998
Cytoband	Xp11.1	SPIN2A SPIN2B	2.03e-05	4	85	2	Xp11.1
Cytoband	11q22.3	MMP1 MMP3 MMP20	7.68e-05	44	85	3	11q22.3
Cytoband	2q21	ERCC3 LCT	3.04e-04	14	85	2	2q21
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	MMP1 MMP3 MMP20	1.06e-03	107	85	3	chr11q22
GeneFamily	Tudor domain containing\|Spindlin family	SPIN2A SPIN2B SPIN3	3.64e-07	5	61	3	1089
GeneFamily	Tudor domain containing	SPIN2A SPIN2B TDRD1 SPIN3	7.13e-06	37	61	4	780
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP1 MMP3 MMP20	7.03e-05	24	61	3	891
GeneFamily	Plexins	PLXNB1 PLXNB3	3.97e-04	9	61	2	683
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA8 ITGA9	1.65e-03	18	61	2	1160
Coexpression	GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_40H_TSST_ACT_DN	TYK2 FLII ERCC3 SLC35G2 ALDH2 BCR SEC23A	3.38e-06	197	84	7	M5322
CoexpressionAtlas	Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2	TINAGL1 VTN MYOM1 GUCY1A1 ITGA8 LAMA5 MMP3 ITGA9 CTSL ITIH5	1.19e-05	453	84	10	GSM777067_500
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TINAGL1 MET LAMA5 ITGA9 EPB41L4A PLXNB1 EPHA7	2.16e-08	157	85	7	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 LAMA5 RTN4RL1 BCR	5.97e-08	182	85	7	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 LAMA5 RTN4RL1 BCR	6.44e-08	184	85	7	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 LAMA5 RTN4RL1 BCR	6.44e-08	184	85	7	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN MYOM1 GUCY1A1 LAMA5 RASD1 BCR	7.45e-08	188	85	7	a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 LAMA5 RASD1 BCR	9.24e-08	194	85	7	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 LAMA5 RASD1 BCR	9.57e-08	195	85	7	0bdf845939bc4b8cc94f2808aea60f818425b076
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN GUCY1A1 RTN4RL1 BCR PLXNB1	1.11e-06	176	85	6	e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN GUCY1A1 RTN4RL1 BCR PLXNB1	1.11e-06	176	85	6	f931192e3cc65414e2245354f443473696cc7ce8
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MET LAMA5 ITGA9 EPB41L4A PLXNB1 EPHA7	1.19e-06	178	85	6	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	TINAGL1 MET MMP3 ITGA9 EPB41L4A EPHA7	1.40e-06	183	85	6	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 RTN4RL1 PABPN1L	1.44e-06	184	85	6	f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET USP8 PON3 ETV5 ITGA9 EPHA7	1.58e-06	187	85	6	6ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.58e-06	187	85	6	accb8a78b885703a27d4b560f0053f03d82ff3af
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 RASD1 RTN4RL1 PLXNB1	1.58e-06	187	85	6	8ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET USP8 PON3 ETV5 ITGA9 EPHA7	1.58e-06	187	85	6	e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	MMP1 ALDH2 MMP3 C8B ITGA9 CTSL	1.69e-06	189	85	6	aac79c41ce7acba722c45c016b2c6997fb772a96
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 KCNS1 PABPN1L PLXNB1	1.74e-06	190	85	6	bfbdf16d488359d7935a419c4c1823288f39c183
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 KCNS1 PABPN1L PLXNB1	1.74e-06	190	85	6	eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCell	Mesenchymal_cells-Smooth_muscle\|World / Lineage and Cell class	TINAGL1 MYOM1 GUCY1A1 ITGA8 RASD1 BCR	1.74e-06	190	85	6	5aa62a363a25f4a110136263b21289a11e8c1e6d
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.74e-06	190	85	6	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN GUCY1A1 RASD1 PABPN1L BCR	1.79e-06	191	85	6	ff7874cc005760a8f3b2e8072fbe418b6bfacaa8
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 PLXNB3	1.79e-06	191	85	6	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 PLXNB3	1.79e-06	191	85	6	6e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 GUCY1A1 ITGA8 LAMA5 RASD1 CXADR	1.79e-06	191	85	6	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	droplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 PLXNB3	1.79e-06	191	85	6	3ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TINAGL1 GUCY1A1 RASD1 ZNF81 CHGB ITIH5	1.85e-06	192	85	6	0b954a4e5857dac45d97c491af9b27cb2d1bd339
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.85e-06	192	85	6	88472b99970ba0decbf87164fc241a1c77b3b389
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.85e-06	192	85	6	a804cb101c3a5585f72217e1143584b1ca436724
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.90e-06	193	85	6	d0dcc0c11ccf99ff6b07e456d25b9742649aadd8
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.90e-06	193	85	6	b9e11cd0896c0868aab7faec4ab7ab4d4e4d1b47
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN MYOM1 GUCY1A1 RASD1 BCR	1.96e-06	194	85	6	52ecec2618c3bb5fdd7fb06b5a40bd6f0aedfe1d
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TINAGL1 GUCY1A1 ITGA8 PON3 TDRD1 ITIH5	2.08e-06	196	85	6	12d9028f90c057c6e5cff00301793fa550e86c5a
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	TINAGL1 ZNF366 LAMA5 NOS2 DISP1	1.66e-05	166	85	5	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	TINAGL1 ZNF366 LAMA5 NOS2 DISP1	1.66e-05	166	85	5	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	ITGA8 ITGA9 BCR TBX1 CXADR	1.97e-05	172	85	5	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZNF366 PABPN1L NOS2 TBX1	2.04e-05	84	85	4	f7ce09c6fb2795b7aecabce00cb9830b3c1a7d0e
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZNF366 PABPN1L NOS2 TBX1	2.04e-05	84	85	4	5d5e519a6652029b9f5275c8e648bbb123fd07b9
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZNF366 PABPN1L NOS2 TBX1	2.04e-05	84	85	4	2b477de422a9f6a8474cba05094577b88236a4f0
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	MET RPGRIP1L EPB41L4A BCR CXADR	2.09e-05	174	85	5	390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCell	droplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 PLXNB1	2.26e-05	177	85	5	dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK2 ALDH2 C8B CTSL ITIH5	2.33e-05	178	85	5	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.33e-05	178	85	5	8bae5db100f4563aa1fc7f881e7f8c59d669e37a
ToppCell	droplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 PLXNB1	2.33e-05	178	85	5	416f85e51f45ec7949451fd47611a84e33e87245
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.33e-05	178	85	5	bc0336692b84bd0fa49747ed5a031b8ed8afa0fd
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERCC3 VTN ITGA8 RTN4RL1 SLC35G2	2.39e-05	179	85	5	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.39e-05	179	85	5	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.39e-05	179	85	5	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 PABPN1L	2.45e-05	180	85	5	78fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASD1 ITGA9 BCR TBX1 ITIH5	2.52e-05	181	85	5	b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASD1 ITGA9 BCR TBX1 ITIH5	2.52e-05	181	85	5	cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASD1 ITGA9 BCR TBX1 ITIH5	2.52e-05	181	85	5	ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.59e-05	182	85	5	9edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TINAGL1 MYOM1 GUCY1A1 ITGA8 ITIH5	2.59e-05	182	85	5	97bb07478f56a937b490fba121ee603db64134a1
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TINAGL1 MYOM1 GUCY1A1 ITGA8 ITIH5	2.59e-05	182	85	5	1c1a687f728341c209b048b6715bcddd0ac20069
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 BCR PLXNB1	2.59e-05	182	85	5	aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 VTN CHGB C8B CDC14A	2.59e-05	182	85	5	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 PABPN1L PLXNB1	2.66e-05	183	85	5	0f02136359787bd78146617990968baa47a65d86
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 MATN1 RASD1	2.66e-05	183	85	5	6f5dbac2748f50105f0f548d189c42ef14287019
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 RTN4RL1 PABPN1L PLXNB1	2.66e-05	183	85	5	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	(7)_Epithelial-H_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TINAGL1 ABCA12 LAMA5 MMP1 MMP3	2.73e-05	184	85	5	1f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VTN GUCY1A1 RTN4RL1 PLXNB1 ITIH5	2.73e-05	184	85	5	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	Mesenchymal_cells-Smooth_muscle\|Mesenchymal_cells / Lineage and Cell class	TINAGL1 MYOM1 GUCY1A1 RASD1 BCR	2.73e-05	184	85	5	83987abaedc26e6da477bc70d65e10b1ab1aea60
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VTN GUCY1A1 RTN4RL1 PLXNB1 ITIH5	2.73e-05	184	85	5	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 RASD1 BCR	2.80e-05	185	85	5	5f5df92b328be396941b5812d00454b5ff927d30
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 GUCY1A1 RASD1 RTN4RL1 PLXNB1	2.80e-05	185	85	5	30df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 RASD1 BCR	2.80e-05	185	85	5	98547c1b1828b76da810ed86082182afaaacdb3f
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF366 ICA1 MMP1 NOS2 TBX1	2.87e-05	186	85	5	86b218a400f9c64f92b050f00b49f09647b17437
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF366 ICA1 MMP1 NOS2 TBX1	2.87e-05	186	85	5	f51c76b1c3c6c49e0ebc9a913d8413e0b6a04d80
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VTN ALDH2 C8B CTSL ITIH5	2.87e-05	186	85	5	cb7df8da6478b96955f3ef1394a0655ec8061bba
ToppCell	COVID-19-Epithelial_cells-Airway_basal\|COVID-19 / group, cell type (main and fine annotations)	MET MMP1 MMP3 EPB41L4A PLXNB1	2.95e-05	187	85	5	8407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET PON3 ETV5 PLXNB1 EPHA7	3.02e-05	188	85	5	b1049003ca79c340bb8c78da66bdc0956e1aebc2
ToppCell	droplet-Lung-21m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MET ETV5 PLXNB1 CXADR EPHA7	3.02e-05	188	85	5	068b761a7b6778bc6d6c776b5f09094aac87477e
ToppCell	facs-Lung-EPCAM-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET PON3 ETV5 PLXNB1 EPHA7	3.02e-05	188	85	5	3dd571bd8e7358b4346dea71f6bf9602dabf583c
ToppCell	droplet-Lung-21m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MET ETV5 PLXNB1 CXADR EPHA7	3.02e-05	188	85	5	c95134245dab9057eb1f9b54acb371470f9c8b86
ToppCell	droplet-Lung-21m-Epithelial-alveolar_epithelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MET ETV5 PLXNB1 CXADR EPHA7	3.02e-05	188	85	5	3ee321a74f04eb0982c7b4977426946b0ae6e5a9
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 PEX5L PLXNB3	3.02e-05	188	85	5	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Erythrophagocytic_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	ETV5 MMP1 MMP3 ITGA9 CTSL	3.18e-05	190	85	5	96c6078619e85f630c9754aca5d6066433e22836
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET ETV5 ITGA9 CXADR EPHA7	3.18e-05	190	85	5	8ff8c586237cf15f930416710bcff45205fe6f70
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET ETV5 PLXNB1 CXADR EPHA7	3.18e-05	190	85	5	aaf5f1c1ff7b1454f4e5dacfeb48e1c3627e3372
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET ETV5 PLXNB1 CXADR EPHA7	3.18e-05	190	85	5	a20123d5c6cb8c2f0dfd99bbfdb571a73c36234d
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 GUCY1A1 ITGA8 LAMA5 RASD1	3.26e-05	191	85	5	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MET PON3 ETV5 C5 EPHA7	3.26e-05	191	85	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 PLXNB1	3.26e-05	191	85	5	5c1f5b6c115b1b27b4a7467a6550ce43c01cf6d0
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ZNF366 LAMA5 MMP1 NOS2 TBX1	3.26e-05	191	85	5	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	PND14-Epithelial-Epithelial_Alveolar\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET ETV5 ITGA9 CXADR EPHA7	3.26e-05	191	85	5	5f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 RTN4RL1	3.26e-05	191	85	5	cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 RTN4RL1	3.26e-05	191	85	5	b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET ETV5 ITGA9 CXADR EPHA7	3.26e-05	191	85	5	2f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCPG1 SLC35G2 CHGB C8B PEX5L	3.26e-05	191	85	5	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MET ETV5 ITGA9 CXADR EPHA7	3.26e-05	191	85	5	4ab3056f9af2a6caed39f32288562f480811cd7b
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	TINAGL1 MET LAMA5 MMP1 MMP3	3.34e-05	192	85	5	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN GUCY1A1 ITGA8 RASD1 PLXNB1	3.34e-05	192	85	5	eb9a0b3d32f90f8b95905c740aab21639dae5cbd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 RTN4RL1	3.34e-05	192	85	5	e5117cdb8af220f60bd1410262078c0306667b4a
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 RASD1 PLXNB1	3.42e-05	193	85	5	1043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ANO4 ETV5 CPZ ITGA9 DISP1	3.42e-05	193	85	5	2f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ZNF366 PIK3R3 LAMA5 MMP1 EPB41L4A	3.42e-05	193	85	5	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	facs-Lung-3m-Epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MET PON3 ETV5 PLXNB1 CXADR	3.42e-05	193	85	5	db5e43e0b571737e7006365bdf0575340b8b900b
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VTN ALDH2 C8B CTSL ITIH5	3.51e-05	194	85	5	412c2b8eb522da6c84f8b00d32d6f0bee555251f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VTN MYOM1 GUCY1A1 ITGA8 RASD1	3.51e-05	194	85	5	3bff2e4eb16719ab7419b2f94c9c6e7302aa6629
Drug	PD-0200347	MMP1 MMP3 NOS2	4.99e-07	5	85	3	ctd:C497431
Drug	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	MMP1 MMP3 NOS2	4.99e-07	5	85	3	ctd:C540360
Drug	dieckol	MMP1 MMP3 NOS2	9.96e-07	6	85	3	ctd:C503840
Drug	dieckol	MMP1 MMP3 NOS2	2.77e-06	8	85	3	CID003008868
Drug	malolactomycin D	RASD1 MMP1 MMP3 MMP20	6.01e-06	32	85	4	CID006449115
Drug	prinomastat	VTN ETV5 MMP1 MMP3	6.82e-06	33	85	4	CID000466151
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	TINAGL1 FLII RPGRIP1L KLHL36 GDPD3 PIK3R3 ALDH2	8.81e-06	196	85	7	4292_DN
Drug	Nialamide [51-12-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	CWH43 ICA1 KCNS1 MMP3 PEX5L TBX1 ITIH5	9.41e-06	198	85	7	3790_UP
Drug	Peptides	MMP1 MMP3 NOS2	1.08e-05	12	85	3	ctd:D010455
Drug	gluconate	TYK2 PIK3R3 MMP1 MMP3 MMP20 NOS2 TBX1 PLXNB3	1.20e-05	287	85	8	CID000000604
Drug	lithium indium	SPIN2A SPIN2B	1.38e-05	2	85	2	CID011116062
Drug	scandium phosphate	SPIN2A SPIN2B	1.38e-05	2	85	2	CID006365269
Drug	AC1L2K7M	MMP1 NOS2	1.38e-05	2	85	2	CID000073636
Drug	rubidium nitrate	SPIN2A SPIN2B	1.38e-05	2	85	2	CID000025731
Drug	palladium oxide	MMP3 NOS2	1.38e-05	2	85	2	CID000073974
Drug	Phe-glu	VTN MMP1 MMP3	1.40e-05	13	85	3	CID000151134
Drug	Chondroitin Sulfates	C5 MMP3 CTSL NOS2	2.00e-05	43	85	4	ctd:D002809
Drug	isoflavone	MMP1 ALDH2 MMP3 MMP20 LCT NOS2	2.54e-05	155	85	6	CID000072304
Drug	2BrP	TYK2 MET RASD1 BCR HDAC1	2.59e-05	93	85	5	CID006540269
Drug	Rgd Peptide	FLII VTN LAMA5 MMP1 MMP3 ITGA9 CXADR	3.17e-05	239	85	7	CID000104802
Drug	alpha-sulfone 21	MMP1 MMP3	4.12e-05	3	85	2	CID009822926
Drug	SI 27	MMP1 MMP3	4.12e-05	3	85	2	ctd:C421267
Drug	NSC354462	RASD1 MMP1 MMP3	4.66e-05	19	85	3	CID000434668
Drug	Nitrogen Compounds	MMP1 MMP3	8.22e-05	4	85	2	ctd:D017672
Drug	carbamoylphosphonic acid	MMP1 MMP3	8.22e-05	4	85	2	CID013879809
Drug	3-hydroxypicolinic acid	MMP1 MMP3	8.22e-05	4	85	2	ctd:C049246
Drug	maltol	MMP1 MMP3	8.22e-05	4	85	2	ctd:C008316
Drug	diphenylketen	SPIN2A SPIN2B	8.22e-05	4	85	2	CID000013696
Drug	diacerein	MMP1 MMP3 MMP20 NOS2	9.11e-05	63	85	4	CID000026248
Drug	Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; PC3; HT_HG-U133A	TINAGL1 CWH43 GDPD3 ICA1 ETV5 MMP3	9.37e-05	196	85	6	3703_DN
Drug	mibolerone	ETV5 MMP1 MMP3	9.60e-05	24	85	3	ctd:C100075
Drug	ng h	MMP1 MMP3 MMP20	1.09e-04	25	85	3	CID000448002
Drug	DA-125	MMP1 MMP3 MMP20	1.23e-04	26	85	3	CID000114758
Drug	beta-sulfone 7f	MMP1 MMP3	1.37e-04	5	85	2	CID011526076
Drug	alpha-sulfone 27e	MMP1 MMP3	1.37e-04	5	85	2	CID011719408
Drug	MMP-3 inhibitor	MMP1 MMP3	1.37e-04	5	85	2	CID010549329
Drug	CTS-1027	MMP1 MMP3	1.37e-04	5	85	2	CID003342298
Drug	SC-276	MMP1 MMP3	1.37e-04	5	85	2	CID009802768
Drug	acetohydroxamic acid	MMP1 MMP3	1.37e-04	5	85	2	ctd:C006358
Drug	alpha-sulfone 35g	MMP1 MMP3	1.37e-04	5	85	2	CID011705502
Drug	beta-sulfone 7d	MMP1 MMP3	1.37e-04	5	85	2	CID011548264
Drug	tongxinluo	MMP1 MMP3	1.37e-04	5	85	2	ctd:C513941
Drug	alpha-sulfone 27g	MMP1 MMP3	1.37e-04	5	85	2	CID011561491
Drug	beta-sulfone 7e	MMP1 MMP3	1.37e-04	5	85	2	CID011641261
Drug	beta-sulfone 7b	MMP1 MMP3	1.37e-04	5	85	2	CID009867183
Drug	CGS 25966	MMP1 MMP3	1.37e-04	5	85	2	CID009821883
Drug	alpha-sulfone 27d	MMP1 MMP3	1.37e-04	5	85	2	CID011532911
Drug	alpha-sulfone 27b	MMP1 MMP3	1.37e-04	5	85	2	CID011697282
Drug	beta-sulfone 7c	MMP1 MMP3	1.37e-04	5	85	2	CID011613649
Drug	anandamide	MMP1 MMP3 NOS2	1.54e-04	28	85	3	ctd:C078814
Drug	pirfenidone	MET MMP1 MMP3 MMP20 NOS2	1.69e-04	138	85	5	CID000040632
Drug	AC1MP5O4	ITGA9 LCT NOS2	1.71e-04	29	85	3	CID003379972
Drug	A0395	LAMA5 MMP1 MMP3 MMP20	1.80e-04	75	85	4	CID009906466
Drug	AC1NSU5S	MMP1 MMP3 MMP20 NOS2	1.80e-04	75	85	4	CID005316299
Drug	mercuric acetate	MMP1 MMP3 MMP20	1.90e-04	30	85	3	CID000015337
Drug	4-aminoproline	MMP1 MMP3	2.05e-04	6	85	2	CID000124558
Drug	varespladib methyl	MMP1 MMP3	2.05e-04	6	85	2	ctd:C545088
Drug	Hydroxamate 12	MMP1 MMP3	2.05e-04	6	85	2	CID010594000
Drug	ethylene acrylic acid	VTN ITGA9	2.05e-04	6	85	2	CID000062701
Drug	AC1L1G9T	TYK2 MET VTN PIK3R3 RASD1 MMP1 BCR NOS2	2.15e-04	433	85	8	CID000003591
Disease	thrombosis (is_implicated_in)	VTN MMP1 MMP3	9.19e-06	15	82	3	DOID:0060903 (is_implicated_in)
Disease	neuroblastoma	DOCK2 LAMA5 CPZ MMP20 EPB41L4A	1.85e-05	116	82	5	EFO_0000621
Disease	immunoglobulin light chain amyloidosis (is_marker_for)	MMP1 MMP3	2.28e-05	3	82	2	DOID:0080933 (is_marker_for)
Disease	obesity (implicated_via_orthology)	TYK2 FLII ETV5 ALDH2 PLXNB1 PLXNB3	3.08e-05	215	82	6	DOID:9970 (implicated_via_orthology)
Disease	vitronectin measurement	VTN C8B NOS2	3.52e-05	23	82	3	EFO_0021843
Disease	septin-10 measurement	VTN C8B	4.56e-05	4	82	2	EFO_0802053
Disease	psoriatic arthritis (is_marker_for)	MMP1 MMP3	4.56e-05	4	82	2	DOID:9008 (is_marker_for)
Disease	NKG2-E type II integral membrane protein measurement	VTN C8B	1.14e-04	6	82	2	EFO_0801842
Disease	carotid stenosis (is_implicated_in)	MMP1 MMP3	1.14e-04	6	82	2	DOID:13001 (is_implicated_in)
Disease	end stage renal disease (is_implicated_in)	ITGA8 MMP1 MMP3	2.04e-04	41	82	3	DOID:783 (is_implicated_in)
Disease	testis-expressed sequence 29 protein measurement	PON3 C8B	2.11e-04	8	82	2	EFO_0802125
Disease	interferon alpha/beta receptor 1 measurement	TYK2 VTN	2.71e-04	9	82	2	EFO_0021850
Disease	WNT1-inducible-signaling pathway protein 1 measurement	VTN C8B	3.38e-04	10	82	2	EFO_0008321
Disease	hypertension (is_implicated_in)	MMP1 ALDH2 ITGA9 NOS2	3.68e-04	121	82	4	DOID:10763 (is_implicated_in)
Disease	interstitial collagenase measurement	MMP1 MMP20	4.13e-04	11	82	2	EFO_0008193
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	TYK2 SET BCR	4.38e-04	53	82	3	C1961099
Disease	Necrosis	SET BCR NOS2	4.89e-04	55	82	3	C0027540
Disease	abdominal aortic aneurysm (biomarker_via_orthology)	MMP3 NOS2	6.79e-04	14	82	2	DOID:7693 (biomarker_via_orthology)
Disease	atrial fibrillation (is_implicated_in)	MMP1 MMP3	6.79e-04	14	82	2	DOID:0060224 (is_implicated_in)
Disease	autosomal dominant polycystic kidney disease (is_marker_for)	ITGA8 MMP1	6.79e-04	14	82	2	DOID:898 (is_marker_for)
Disease	Colorectal Carcinoma	ABCA12 OTOP2 MMP1 ALDH2 PEX5L CDC14A TBX1 EPHA7	7.48e-04	702	82	8	C0009402
Disease	atherosclerosis (is_implicated_in)	PON3 MMP1	8.93e-04	16	82	2	DOID:1936 (is_implicated_in)
Disease	renal cell carcinoma (is_implicated_in)	MET MMP1 MMP3	9.50e-04	69	82	3	DOID:4450 (is_implicated_in)
Disease	Necrotizing Enterocolitis	ALDH2 NOS2	1.01e-03	17	82	2	C0520459
Disease	Antibody Deficiency Syndrome	C5 C8B	1.01e-03	17	82	2	C0003257
Disease	otitis media (biomarker_via_orthology)	CTSL NOS2	1.01e-03	17	82	2	DOID:10754 (biomarker_via_orthology)
Disease	white matter lesion progression measurement	DOCK2 MMP3 TBX1	1.03e-03	71	82	3	EFO_0007746
Disease	DiGeorge syndrome (implicated_via_orthology)	ZNF366 TBX1	1.27e-03	19	82	2	DOID:11198 (implicated_via_orthology)
Disease	Esophageal Neoplasms	MET ALDH2 NOS2	1.35e-03	78	82	3	C0014859
Disease	Malignant neoplasm of esophagus	MET ALDH2 NOS2	1.35e-03	78	82	3	C0546837
Disease	Asthma	MMP1 ALDH2 NOS2	1.46e-03	80	82	3	C0004096
Disease	periodontitis (biomarker_via_orthology)	MET MMP3	1.55e-03	21	82	2	DOID:824 (biomarker_via_orthology)
Disease	esophagus adenocarcinoma (is_implicated_in)	MMP1 MMP3	1.55e-03	21	82	2	DOID:4914 (is_implicated_in)
Disease	hypertrophic cardiomyopathy (is_implicated_in)	MMP1 CTSL	1.70e-03	22	82	2	DOID:11984 (is_implicated_in)
Disease	Neoplasm Invasiveness	MET SET MMP1 MMP3	1.75e-03	184	82	4	C0027626
Disease	Immunologic Deficiency Syndromes	C5 C8B	1.86e-03	23	82	2	C0021051
Disease	idiopathic pulmonary fibrosis (is_marker_for)	MMP1 MMP3	1.86e-03	23	82	2	DOID:0050156 (is_marker_for)
Disease	unipolar depression, neuroticism measurement	ANO4 ZNF366	2.02e-03	24	82	2	EFO_0003761, EFO_0007660
Disease	Cerebral Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0750935
Disease	Intracranial Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0750936
Disease	Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0004114
Disease	Grade I Astrocytoma	MET MMP3	2.20e-03	25	82	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0205768
Disease	Mixed oligoastrocytoma	MET MMP3	2.20e-03	25	82	2	C0547065
Disease	Pilocytic Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0334583
Disease	Juvenile Pilocytic Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0280783
Disease	Diffuse Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0280785
Disease	Childhood Cerebral Astrocytoma	MET MMP3	2.20e-03	25	82	2	C0338070
Disease	Gemistocytic astrocytoma	MET MMP3	2.37e-03	26	82	2	C0334581
Disease	Protoplasmic astrocytoma	MET MMP3	2.37e-03	26	82	2	C0334580
Disease	Fibrillary Astrocytoma	MET MMP3	2.37e-03	26	82	2	C0334582
Disease	Adenocarcinoma of large intestine	TYK2 MET EPHA7	2.45e-03	96	82	3	C1319315
Disease	Anaplastic astrocytoma	MET MMP3	2.56e-03	27	82	2	C0334579
Disease	myocardial infarction (is_implicated_in)	MMP1 ALDH2 MMP3	2.68e-03	99	82	3	DOID:5844 (is_implicated_in)
Disease	primary biliary cholangitis (biomarker_via_orthology)	MMP3 NOS2	2.75e-03	28	82	2	DOID:12236 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TEFKHPGDFYVQLYS	TDRD1	271	Q9BXT4
DKFSGHPKGYAYIEF	PABPN1L	181	A6NDY0
GYIFLEYASPAHAVD	EIF3B	231	P55884
PELYEIHKEFYDGLF	BCR	551	P11274
IYEAKRFTDAGFEHY	CDC14A	231	Q9UNH5
PFYLKEAFGDGYHLT	ABCA12	1561	Q86UK0
DKESYPVFYLFRDGD	ERP29	111	P30040
YEAAFPLHEGSYRSK	ANO4	291	Q32M45
DFAVHYGVAYRLAPD	DISP1	1051	Q96F81
EYYLGFTVFPTHDSK	CLK1	371	P49759
ELPDYAPDYQHKFSF	RTN4RL1	376	Q86UN2
DAYTPTIEDFHRKFY	RASD1	51	Q9Y272
IYYADVKDPEHFPFV	RAB9B	106	Q9NP90
VAHPGFYAVIKFYSA	RDM1	56	Q8NG50
KRYHEDIFGAVFPYE	NOS2	1121	P35228
PRFTYGHAGTIYKDF	KLHL36	431	Q8N4N3
KFARLPEEEFGHFYT	FLII	916	Q13045
PVAEHYFYTADFKTI	MATN1	426	P21941
PHPYVVYKFFDFADH	RPGRIP1L	811	Q68CZ1
DGEYKDYLAFHPFDT	ITIH5	916	Q86UX2
NDYFEYFGPDFKLHI	HDAC1	331	Q13547
ISFAVREHGDFYPFD	MMP3	161	P08254
LDYKVYAERIFFPGH	PLXNB1	1566	O43157
LDYRTYAERAFFPGH	PLXNB3	1331	Q9ULL4
SEKGYYFHTENPFKD	PEX5L	311	Q8IYB4
PKFERDLFYHGTFRD	LCT	891	P09848
YKEKLEVYFSPGHFA	GDPD3	111	Q7L5L3
DEAAREFYFDRHPGF	KCNS1	96	Q96KK3
SHEGFSYEKDPRLYF	ETV5	321	P41161
FGYLREEPLDKSYDF	LAMA5	1386	O15230
EGDEELYFHFKFPGT	EPHA7	591	Q15375
YFGYAVDFHIPDART	ITGA8	56	P53708
RPHFSNTVEVDFYGY	OTOP2	516	Q7RTS6
APKEDDFAGAVYIYH	ITGA9	386	Q13797
YHRDGKYGFSDPLTF	PIK3R3	116	Q92569
VFEKLDEYIYRHFFG	CCPG1	721	Q9ULG6
YSAEYAVFETGARHP	IDH3B	296	O43837
PYFLDCHRYFTREDE	CPZ	141	Q66K79
YEKAFFTEEYVRDHP	DOCK2	1546	Q92608
YFHSRDYKNPEGFTG	FMO5	171	P49326
DDYYPDLKGRVHFTS	CXADR	81	P78310
YDNGFLFIHTDKPVY	C5	121	P01031
DGHIFLEAFSPVYKY	ERCC3	81	P19447
DPYKHTAGYVSEYRF	EPB41L4A	151	Q9HCS5
EPLHFFEDYFFHKRD	EFCAB3	271	Q8N7B9
LHYRKKSAEFPDFYD	CHGB	611	P05060
GEYRDLFRDFGTHYI	C8B	331	P07358
AIHESFKGYQPYEFT	ICA1	251	Q05084
YEVAERGTAYFFKGP	MMP20	351	O60882
KLGFYTDFGPSTRYH	CWH43	486	Q9H720
DRYDEPVLHFGDAEY	FREM3	2006	P0C091
FRDSYPIKYVHAFES	MET	241	P08581
HHYRGKRDDFFYEDR	RBM7	226	Q9Y580
EDFFLYKGGIYSHTP	TINAGL1	371	Q9GZM7
RGDFFYHSENPKYPE	TMEM43	221	Q9BTV4
YFRFYGRIVDKPGDH	TRNT1	201	Q96Q11
PKGYSFYLAHEFFDV	NDUFAF7	206	Q7L592
PYRSSFYALEEKHVG	NBPF12	1076	Q5TAG4
VLHGYPKDIYSSFGF	MMP1	356	P03956
PALFKSYAEYGHFVD	TAF2	871	Q6P1X5
AFLGVYYALDKFHPA	SLC35G2	331	Q8TBE7
DFEFALVFYHRGYKL	ODAD4	96	Q96NG3
HSFEEKYGRAHPVFY	FAF2	141	Q96CS3
IKSGYRIDFYFDENP	SETSIP	141	P0DME0
IKSGYRIDFYFDENP	SET	131	Q01105
PSVYFIKFDDDFHIY	SPIN2A	236	Q99865
GDYDDSAFVEPRYHV	POTEI	121	P0CG38
KFGEYHKDDPSSFRF	SEC23A	556	Q15436
AGHESFLFYKEGIYF	CTSL	251	P07711
YHGKTIPIDGDFFSY	ALDH2	156	P05091
HKKRTGFYRDYDIPF	ZC3H6	96	P61129
FHPLFEYFDYESRKS	VPS35	421	Q96QK1
PSVYFIKFDDDFHIY	SPIN3	236	Q5JUX0
PSVYFIKFDDDFHIY	SPIN2B	236	Q9BPZ2
VLGPEQFYATRDHYF	PON3	171	Q15166
GPSFSDYLYFKHRDE	ZNF366	711	Q8N895
FYDFRSSYPDHKEGE	ZNF622	346	Q969S3
DFVPVDDKRYRYAFH	TBX1	161	O43435
PAHSYSGRERVYFFK	VTN	261	P04004
AKFLDPITGTFRYYH	USP8	656	P40818
DYEYKDFGKFVHPSP	ZNF81	166	P51508
DFGLAKAVPEGHEYY	TYK2	1041	P29597
EDDFLHVYYFFPKRT	GUCY1A1	196	Q02108
FDYVDKFLDPGFSSH	NAALADL1	551	Q9UQQ1
PYGYASRFEIHFDDK	MYOM1	396	P52179