Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of cell fate commitment

TNFSF18 RBBP4 CHD3 LOXL3 IL23R

1.71e-05531255GO:0010453
GeneOntologyBiologicalProcessregulation of T-helper 17 cell lineage commitment

TNFSF18 LOXL3 IL23R

3.46e-05111253GO:2000328
DomainFUN14

FUNDC1 FUNDC2

4.30e-0521232IPR007014
DomainFUN14

FUNDC1 FUNDC2

4.30e-0521232PF04930
DomainKASH

SYNE1 SYNE2

2.56e-0441232IPR012315
DomainKASH

SYNE1 SYNE2

2.56e-0441232PS51049
DomainKASH

SYNE1 SYNE2

2.56e-0441232SM01249
DomainKASH

SYNE1 SYNE2

2.56e-0441232PF10541
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

KMT2B IPO7 RBBP4 RBBP5 RADX CHD3 MORC2 RFX1 DHCR7 SMARCD2 USP39 HOMEZ BRWD1

4.64e-076081291336089195
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SFMBT1 NUP107 TRPM7 INPP5B PCDHB2 PKHD1L1 LRIG2 LRIG3 PI4KA FURIN DHCR7 SDK1 PTCD3

6.83e-067771291335844135
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

RBBP4 CHD3 SMARCA2

8.05e-0611129310204490
Pubmed

The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea.

LRIG2 LRIG3

1.37e-052129215203213
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

1.37e-052129211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

1.37e-052129224931616
Pubmed

Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line.

LRIG2 LRIG3

1.37e-052129217393120
Pubmed

Comparative aspects of p73 and Reelin expression in Cajal-Retzius cells and the cortical hem in lizard, mouse and human.

RELN TP73

1.37e-052129217189620
Pubmed

Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.

LRIG2 LRIG3

1.37e-052129234839782
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

1.37e-052129222768332
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

1.37e-052129217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

1.37e-052129224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

1.37e-052129224586179
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

1.37e-052129217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

1.37e-052129231578382
Pubmed

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

RELN SYNE1 SYNE2

1.76e-0514129319874786
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

KMT2B RBBP4 RBBP5 HAUS5 DGKZ CHD3 THAP7 C7orf25 PI4KA SYNE2 EHF FUNDC2 ROBO2 DENND5A WWC1

1.92e-0511241291521900206
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

XRN2 RBBP5 HAUS5 CHD3 PI4KA SMARCA2 SMARCD2 USP39 PTCD3

2.38e-05410129926949251
Pubmed

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

RBBP4 CHD3 SMARCD2

2.69e-0516129330760870
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

SFMBT1 SYNE1 DGKZ RYR3 MICAL2 ALDH16A1

4.05e-05168129630631154
Pubmed

Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement.

FURIN MMP14

4.09e-053129221152186
Pubmed

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.

SYNE2 MMP14

4.09e-053129229934494
Pubmed

Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.

FURIN MMP14

4.09e-053129217283058
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

4.09e-053129216079285
Pubmed

LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.

LRIG2 LRIG3

4.09e-053129227628597
Pubmed

The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.

FURIN MMP14

4.09e-053129222038627
Pubmed

[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].

FURIN MMP14

4.09e-053129229265076
Pubmed

Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.

NELL1 ROBO2

4.09e-053129230700556
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

4.09e-053129210878022
Pubmed

Redistribution of LRIG proteins in psoriasis.

LRIG2 LRIG3

4.09e-053129218037903
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

4.09e-053129212408964
Pubmed

Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.

FURIN MMP14

4.09e-053129226283728
Pubmed

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.

LRIG2 LRIG3

4.09e-053129233469151
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

4.09e-053129217462627
Pubmed

Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.

NELL1 ROBO2

4.09e-053129235940226
Pubmed

Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.

FURIN MMP14

4.09e-053129220608975
Pubmed

[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas].

FURIN MMP14

4.09e-053129225552509
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

4.09e-053129233472039
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

4.09e-053129225516977
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

XRN2 NUP107 RBBP5 RPS6KC1 USP10 WDR6 SMARCA2 SMARCD2 CDC20

4.11e-05440129934244565
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CUL4A IPO7 NUP107 RBBP4 RBBP5 RFX1 ATP6V1H WDR6 ALDH16A1 PTCD3

4.80e-055601291035241646
Pubmed

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

RBBP4 CHD3 SMARCA2

6.31e-0521129312453419
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

XRN2 IPO7 NUP107 RBBP4 RBBP5 CHD3 USP10 SMARCA2 USP39 CDC20

6.61e-055821291020467437
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CUL4A NUP107 RBBP4 HAUS5 CHD3 LRIG3 WDR6 SMARCA2 SMARCD2 XYLB WWC1 TP73 PTCD3 BRWD1

7.18e-0511161291431753913
Pubmed

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.

HSPG2 RELN TP73

7.29e-0522129318448648
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

RBBP4 MORC2 RPS6KC1 USP10 WDR6 PI4KA A2ML1 SMARCD2 USP39

7.39e-05475129931040226
Pubmed

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

KMT2B RBBP5 SMARCA2 SMARCD2

8.00e-0561129420305087
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

8.15e-054129216648470
Pubmed

DeltaNp73 transcription factors modulate cell survival and tumor development.

RELN TP73

8.15e-054129220372082
Pubmed

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

FURIN MMP14

8.15e-054129215911696
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

8.15e-054129228716842
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

8.15e-054129223071752
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

8.15e-054129220108321
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

8.15e-054129219596800
Pubmed

The role of IL-23/IL-17 axis in human kidney allograft rejection.

IL17RC IL23R

8.15e-054129230024651
Pubmed

APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma.

EGLN3 CDC20

8.15e-054129233039559
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CUL4A FKBP15 XRN2 IPO7 RBBP4 RBBP5 CHD3 MORC2 USP10 NAE1 SMARCA2 SMARCD2 USP39

1.06e-0410141291332416067
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

FKBP15 TRPM7 RPS6KC1 LRIG2 LRIG3 WDR6 PI4KA FURIN SYNE2

1.16e-04504129934432599
Pubmed

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours.

RELN TP73

1.36e-045129210716451
Pubmed

The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.

NELL1 MGAT5B

1.36e-045129222823124
Pubmed

A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.

CUL4A SENP8

1.36e-045129220190741
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

SYNE1 SYNE2

1.36e-045129222632968
Pubmed

A new NEDD8-ligating system for cullin-4A.

CUL4A NAE1

1.36e-04512929694792
Pubmed

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.

EGLN3 USP10

1.36e-045129230067985
Pubmed

Developmental roles of p73 in Cajal-Retzius cells and cortical patterning.

RELN TP73

1.36e-045129215525772
Pubmed

Cajal-Retzius neurons are required for the development of the human hippocampal fissure.

RELN TP73

1.36e-045129230861578
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2B RBBP5

1.36e-045129226320581
Pubmed

The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.

CUL4A TP73

1.36e-045129223085759
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE1 SYNE2

1.36e-045129218396275
Pubmed

Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2.

FURIN MMP14

1.36e-04512928804434
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

HSPG2 KMT2B SYNE1 LRIG3 LRP5 SDK1

1.53e-04214129622199357
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

SFMBT1 RBBP4 SMARCA2 BRWD1

1.79e-0475129425593309
Pubmed

CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.

CUL4A RBBP4

2.03e-046129225795299
Pubmed

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.

SENP8 NAE1

2.03e-046129225581363
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE1 SYNE2

2.03e-046129233058875
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2

2.03e-046129218827015
Pubmed

The C terminus of p73 is essential for hippocampal development.

RELN TP73

2.03e-046129232571922
Pubmed

Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis.

USP10 USP39

2.03e-046129235636624
Pubmed

The role of Robo3 in the development of cortical interneurons.

RELN ROBO2

2.03e-046129219366869
Pubmed

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.

RBBP4 CHD3

2.03e-046129220547755
Pubmed

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

RBBP4 USP10 WDR6

2.08e-0431129326678539
Pubmed

Human chromosome 11 DNA sequence and analysis including novel gene identification.

TMPRSS13 TRIM49D1 ZP1 EHF

2.30e-0480129416554811
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

RELN SYTL2 FREM1 NAE1 HSD3B2 RIMS1 WWC1

2.46e-04331129719490893
Pubmed

Deubiquitylation and stabilization of PTEN by USP13.

USP10 USP39

2.83e-047129224270891
Pubmed

Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.

CDC20 TP73

2.83e-047129222340593
Pubmed

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.

LRIG2 LRIG3

2.83e-047129220446891
Pubmed

Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures.

RELN TP73

2.83e-047129236982451
Pubmed

The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).

NELL1 FANCF

2.83e-047129215124103
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2B RBBP5

2.83e-047129230604749
Pubmed

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.

DHCR7 HSD3B2 GGPS1

3.53e-0437129326108225
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

CUL4A NUP107 CHD3 RRN3 SMARCA2 USP39

3.54e-04250129633536335
Pubmed

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

RBBP4 CHD3

3.77e-048129211850410
Pubmed

Covalent modification of all members of human cullin family proteins by NEDD8.

CUL4A NAE1

3.77e-048129210597293
Pubmed

Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.

HSPG2 MMP14

3.77e-048129231600777
Pubmed

Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.

CHD3 TP73

3.77e-048129210961991
Pubmed

NEDDylation controls the target specificity of E2F1 and apoptosis induction.

SENP8 TP73

3.77e-048129223001041
Pubmed

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

LRIG2 LRIG3

3.77e-048129226651291
Pubmed

In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.

LRIG2 LRIG3

3.77e-048129224086156
Pubmed

The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.

RBBP4 CHD3

3.77e-048129211297506
Pubmed

MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.

RBBP4 CHD3

3.77e-048129212705869
Cytoband15q14-q15

RYR3 IVD

7.79e-055129215q14-q15
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.43e-0448921252
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 HEPACAM2 LRIG2 LRIG3 ROBO2 SDK1

1.43e-04161896593
GeneFamilyWD repeat domain containing

RBBP4 RBBP5 STXBP5L CFAP52 WDR6 CDC20 BRWD1

3.10e-04262897362
GeneFamilyBlood group antigens|CD molecules|Proteoglycans

HSPG2 TGFBR3

4.95e-047892570
GeneFamilyPHD finger proteins|NuRD complex

RBBP4 CHD3

1.53e-03128921305
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE RELN STXBP5L RGS22 PKHD1L1 FREM1 RYR3 SDK1

6.72e-0818412982cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE RELN STXBP5L RGS22 PKHD1L1 FREM1 RYR3 SDK1

6.72e-081841298ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE RELN STXBP5L RGS22 PKHD1L1 FREM1 RYR3 SDK1

6.72e-0818412982b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SYNE1 SYTL2 CHD3 ATP8B2 ITK TGFBR3 SYNE2 PPP1R16B

1.14e-071971298c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellhealthy_donor-Lymphocytic|healthy_donor / Disease condition, Lineage, Cell class and subclass

SYNE1 SYTL2 CHD3 ATP8B2 ITK TGFBR3 SYNE2 PPP1R16B

1.23e-0719912982841e16d54acd344ba454f024e285c28abc37319
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 SYTL2 ANKS1B ADAMTS12 TGFBR3 NELL1 ROBO2 MMP14

1.23e-0719912986b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SYTL2 PPOX TGFBR3 SYNE2 PPP1R16B CDC20

5.85e-071671297abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RADX SYNE1 SYTL2 SYNE2 PRORP TRAV25 IL23R

9.32e-071791297a634ca46ffc394c5f5215fc5d8eae4a77819af9c
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RADX SYNE1 SYTL2 SYNE2 PRORP TRAV25 IL23R

9.32e-07179129735f014b6e752626909d829c5ab9bb761c1f3e3dc
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B WWC1

1.29e-061881297186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellAdult-Immune-T_lymphocyte-D175|Adult / Lineage, Cell type, age group and donor

SYTL2 ATP8B2 ITK PCNX2 SYNE2 PPP1R16B IL23R

1.44e-0619112970b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYTL2 ATP8B2 ITK PCNX2 SYNE2 PPP1R16B IL23R

1.54e-061931297b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCellhealthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

SYNE1 SYTL2 CHD3 ATP8B2 ITK TGFBR3 SYNE2

1.71e-061961297af00c31612e4fe068e5fccae05368edba46bbd20
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TRHDE SYNE1 FREM1 ADAMTS12 NELL1 MMP14 SDK1

1.95e-0620012979b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

TRHDE SYNE1 SYTL2 FREM1 ADAMTS12 NELL1 MMP14

1.95e-062001297bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellCOVID-19_Severe-multiplets|COVID-19_Severe / disease group, cell group and cell class

SYNE1 SYTL2 PCDHB2 TGFBR3 SYNE2 EHF

5.44e-061521296451745151322c2fcea22dbb3dba681e12634a510
ToppCellSevere-Lymphoid-T-|Severe / Condition, Lineage, Cell class and cell subclass

SYNE1 SYTL2 CHD3 ITK SYNE2 PPP1R16B

1.03e-0517012965788e1158fde036937d41708e9db3222ca351eb1
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SGSM1 RBBP5 LRIG2 LPIN3 FUNDC2

1.10e-051721296b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SGSM1 RBBP5 LRIG2 LPIN3 FUNDC2

1.10e-0517212962f1673fcb2356684d60871debb0f159aec553a1c
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGLN3 RELN SGSM1 LBP PKHD1L1 RYR3

1.22e-051751296f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN SGSM1 LBP PKHD1L1 RYR3 MMP14

1.22e-05175129684d252f3e432231687613299bbea14978bb4b06b
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN SGSM1 LBP PKHD1L1 RYR3 MMP14

1.22e-051751296a00c6fa9b33640710dd05a3799031147196f0986
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SWAP70 ANKS1B HEPACAM2 CD37 PPP1R16B WWC1

1.43e-051801296c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SWAP70 ANKS1B HEPACAM2 CD37 PPP1R16B WWC1

1.43e-051801296d8135f73a89b97168f2048258f4648e23536ece4
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYTL2 ANKS1B ADAMTS12 NELL1 ROBO2 RIMS1

1.57e-05183129612daaea821e49bc94a01e2496331e92a80d27339
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANKS1B ADAMTS12 TGFBR3 NELL1 ROBO2 RIMS1

1.67e-0518512966712512100ccef456d2e2bd201d0987986c92ac9
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE SGSM1 HEPACAM2 FURIN A2ML1 EHF

1.67e-051851296686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ANKS1B TGFBR3 NELL1 ROBO2 RIMS1

1.67e-051851296e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellControl-Lymphoid-Tregs|Control / Condition, Lineage and Cell class

SYNE1 ANKS1B ATP8B2 ITK SYNE2 IL23R

1.72e-0518612966144f32a370594e45b91da142b4f435370c69b9a
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 DGKZ CHD3 ATP8B2 ITK SYNE2

1.77e-051871296e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SFMBT1 RADX ATP8B2 ZP1 USP10 SYNE2

1.83e-0518812963e3055dacc05a932f2beb114babf1dc76994e1af
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SGSM1 LBP PKHD1L1 TGFBR3 MMP14

1.83e-051881296dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

SYTL2 ANKS1B RYR3 MICAL2 RIMS1 SDK1

1.83e-05188129634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE STXBP5L SYTL2 NELL1 MICAL2 MGAT5B

1.83e-05188129650c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRHDE SYTL2 FREM1 EHF SDK1 WWC1

1.83e-0518812968f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SGSM1 LBP PKHD1L1 TGFBR3 MMP14

1.83e-0518812962ef08313087e91985bcffc46c3798470cdeec49c
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN SGSM1 LBP PKHD1L1 TGFBR3 MMP14

1.83e-0518812961f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

SYTL2 ANKS1B RYR3 MICAL2 RIMS1 SDK1

1.88e-0518912966b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

1.88e-051891296b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE4B SYNE1 SYTL2 ITK SYNE2 PPP1R16B

1.94e-05190129655df73c8b696967a925b1772631f6900eff0fa30
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE4B SYNE1 SYTL2 ITK SYNE2 PPP1R16B

1.94e-051901296494fbab37305a7f92cddec75b291d42282555f5f
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRHDE FREM1 ADAMTS12 NELL1 MMP14 SDK1

1.94e-051901296d60395739458d7f47a3350ade751fe3819500320
ToppCellsevere-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PDE4B ANKS1B ATP8B2 HERC2P3 ITK SYNE2

2.00e-051911296afff6bfae9a2f1e17d2731315e7fe63c4601679f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SYTL2 ATP8B2 ITK TGFBR3 SYNE2

2.00e-051911296b9ef6d82b86271b7e0875a399bb9aae84ef5bad3
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

HSPG2 SYNE1 PKHD1L1 PIK3C2A SYNE2 PPP1R16B

2.00e-051911296c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellCOPD-Lymphoid-T|World / Disease state, Lineage and Cell class

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.06e-051921296eb4909574fb5fc91399463523e2737095773200a
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

HSPG2 SYNE1 PKHD1L1 PIK3C2A SYNE2 PPP1R16B

2.06e-0519212968a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellCOPD-Lymphoid|COPD / Disease state, Lineage and Cell class

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.06e-051921296064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCellControl-Lymphoid-T|World / Disease state, Lineage and Cell class

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.06e-051921296253cf4d2cf88ad8c45b73779336180840bef054b
ToppCellIPF-Lymphoid-T|World / Disease state, Lineage and Cell class

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.06e-051921296b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCellControl-Lymphoid-T|Control / Disease state, Lineage and Cell class

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.12e-051931296af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SYTL2 ITK LRIG2 SYNE2 BRWD1

2.12e-0519312969337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellAdult-Immune-T_lymphocyte|Adult / Lineage, Cell type, age group and donor

SYTL2 ATP8B2 ITK PCNX2 SYNE2 PPP1R16B

2.12e-05193129626df0c4c8a2355dd5503fadd07e368eb9a2bf06a
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.12e-0519312969c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 IL23R

2.18e-051941296c30b6d1fd5fabd99e25857f7486d6dc9c054f552
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYTL2 ATP8B2 ITK PCNX2 SYNE2 PPP1R16B

2.18e-0519412963d6f2d190dd50804afea299957cc44c2bb756134
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 IL23R

2.18e-051941296749cc39cbe5d68372fc43f7dbdbe5004cd01ace8
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 IL23R

2.18e-051941296a7f11ac46965b3fc21c9d04870ce0bd2b3868cec
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRHDE SYNE1 FREM1 ADAMTS12 NELL1 SDK1

2.18e-05194129660622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellControl-T/NK-CD4+_T_1|Control / Disease group,lineage and cell class （2021.01.30）

SYNE1 SYTL2 ATP8B2 ITK SYNE2 IL23R

2.18e-051941296908cc9a3b0b99aea28a24bbd27667c824743e967
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRHDE SYNE1 FREM1 ADAMTS12 NELL1 SDK1

2.18e-0519412966e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellCOPD-Lymphoid-T|COPD / Disease state, Lineage and Cell class

SFMBT1 SYTL2 ITK SYNE2 SMARCA2 PPP1R16B

2.31e-05196129630e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.31e-051961296e4c76e7ad68455e51fe93ce588bcec9383f8654b
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-T_reg|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE4B ANKS1B ATP8B2 ITK SYNE2 PPP1R16B

2.31e-051961296b60e5bf9a45c08e0ca12c7e2ac2009ea53e04f4e
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.38e-05197129648311c7d85ffabf59fd1685c31c18b3e84a145b5
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B-Plasmablast|Influenza_Severe / Disease, condition lineage and cell class

HSPG2 RADX PKHD1L1 LRP5 CDC20 TP73

2.38e-0519712969108edafbf5744ed65f556bcbbf819a9b71176a9
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SYTL2 CHD3 ITK SYNE2 SMARCA2

2.38e-05197129657ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.38e-05197129692f35ea602489efd29ce3a8a186d1f70d65faf40
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 CDC20

2.38e-05197129632b770e403028862f91e4727f4a8fbb6151910e4
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.38e-051971296cd39574b5a81a361a7940c4eb26e82652addc9e9
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EGLN3 TGFBR3 ROBO2 LOXL3 RIMS1 MMP14

2.38e-0519712969d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.38e-051971296a26dd66a6bd08b46657b3a7c41669e206a8887b3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SYTL2 ATP8B2 ITK TGFBR3 SYNE2

2.38e-05197129659b1fb93a39dcf8c994d2b7dc2906dae74c57527
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.38e-0519712964946a9495ee8824540c4b45bd2a1a75696b71534
ToppCellSevere_COVID-19-T/NK-CD8+_T|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-051981296584f0dc6f22bb13956a5f6950698599e382907e9
ToppCellCOVID_vent-Lymphocytic|COVID_vent / Disease condition, Lineage, Cell class and subclass

SYNE1 CHD3 ATP8B2 ITK TGFBR3 SYNE2

2.44e-051981296ee80f647317377081b4bd194ee2801f556b3a53b
ToppCellControl-T/NK|Control / Disease group,lineage and cell class （2021.01.30）

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.44e-051981296840c422cc79318e85f75641b1a7eac93b120701f
ToppCellHealthy_Control-Lymphoid|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SYTL2 ATP8B2 ITK SYNE2 PPP1R16B CDC20

2.44e-051981296c176c583f426e4373daca4a696ab8832e838cfbf
ToppCellBAL-Control-Lymphocyte-T/NK|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.44e-0519812962f1624f61c20452aa6e0151cec3976c06102b01a
ToppCellT_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SYNE1 SYTL2 CHD3 ITK TGFBR3 SYNE2

2.44e-0519812961ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-0519812962eb80255bacddbf778b1c9eec09f74b4cdb09b36
ToppCellsevere_COVID-19-CD8+_Tem|severe_COVID-19 / disease group, cell group and cell class (v2)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-05198129669d49f37cf5095e65c71cddc6d43748322ff19a3
ToppCellmild_COVID-19_(asymptomatic)-CD8+_Tem|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

SYNE1 SYTL2 ITK TGFBR3 DHCR7 SYNE2

2.44e-051981296a7519bbbb67d319635ddbe05a2a154c46b77ce87
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-051981296ec99da4e269c4cd982a395cdac0e4487ab14ec39
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-05198129606fdf8554148d11c0a946a7fd200edd9fa7e1965
ToppCellmild_COVID-19_(asymptomatic)-CD4+_CTL|World / disease group, cell group and cell class (v2)

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.44e-05198129603c01fc384d46eec55ff730edbab8a3fde618ed8
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE4B SYTL2 ITK PPP1R16B TRAV25 IL23R

2.44e-051981296cdb4d65a125a57a98287761d049cc34e6ae1d6bf
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.51e-0519912968b524d5fdece8fbeb8889da3f86da7f20e646fff
ToppCellBAL-Control-Lymphocyte-T/NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.51e-05199129655f23aef431fc1965d2442ff9c7b32ee33bc0d69
ToppCellCOVID-19-Lymphoid-CD8_T_cells|COVID-19 / Condition, Lineage and Cell class

SYNE1 SYTL2 ITK TGFBR3 SYNE2 PPP1R16B

2.51e-0519912968e322d0d097df160554e3024ec9edae4a77a66cc
ToppCellMild_COVID-19-T/NK-CD8+_T|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.51e-05199129627a1b62e270cad1defa80f04f4ee5b5c8e448792
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 SYTL2 FREM1 ADAMTS12 TGFBR3 MMP14

2.51e-051991296a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellHealthy_Control-Lymphoid-T|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SYNE1 SYTL2 ATP8B2 ITK SYNE2 CDC20

2.51e-051991296f22438fc9c02d0a4d7c936f9420b913aca851ea1
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.51e-051991296b051e3890bec7b8c6dc36ea433b53b9297839783
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SYNE1 FREM1 ADAMTS12 TGFBR3 NELL1 MMP14

2.51e-05199129630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ATP8B2 ITK SYNE2 PPP1R16B

2.51e-051991296a4a8a690d03e063bc4bbfb20429ade8b4e38b79d
ToppCellsevere-gd_T|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPP2 SYNE1 SYTL2 TGFBR3 SYNE2 IL23R

2.51e-051991296e5a17a9f8f3be05d6abe1116607d17633df3c7ef
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

TRHDE SYNE1 FREM1 ADAMTS12 NELL1 MMP14

2.59e-05200129664ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellPBMC-Control-Lymphocyte-T/NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 SYTL2 ATP8B2 ITK TGFBR3 SYNE2

2.59e-0520012961dd0141e87902d96a76edcd966988f61a532c808
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE FREM1 ADAMTS12 TGFBR3 ROBO2 SDK1

2.59e-052001296389cc775c8419d90fb77cd794376d2160a7bf44e
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.05e-0441242cv:CN293514
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.74e-0451242C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.74e-0451242C0410190
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

PDE4B ANKS1B FURIN SYNE2 PPP1R16B RIMS1

2.07e-042001246EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.60e-0461242cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

2.60e-0461242C0410189
Diseaseprimary ciliary dyskinesia (is_implicated_in)

TP73 BRWD1

2.60e-0461242DOID:9562 (is_implicated_in)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

3.63e-0471242C0751337
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

1.12e-03121242DOID:11726 (implicated_via_orthology)
Diseaseanxiety disorder, stress-related disorder

PDE4B SDK1

1.12e-03121242EFO_0006788, EFO_0010098
Diseaserevision of total hip arthroplasty

RXFP3 ADAMTS12

1.54e-03141242EFO_0020973
Diseaseearly cardiac repolarization measurement

LRP5 MGAT5B

1.54e-03141242EFO_0004885
DiseaseAlzheimer disease, peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease

IL34 PDE4B

1.77e-03151242EFO_0003948, EFO_0009923, MONDO_0004247, MONDO_0004975
DiseaseInherited oocyte maturation defect

ZP1 CDC20

2.02e-03161242cv:CN238505
DiseaseSynostotic Posterior Plagiocephaly

FREM1 NELL1

2.02e-03161242C1833340
DiseaseCraniosynostosis, Type 1

FREM1 NELL1

2.02e-03161242C4551902
DiseaseAcrocephaly

FREM1 NELL1

2.02e-03161242C0030044
DiseaseTrigonocephaly

FREM1 NELL1

2.02e-03161242C0265535
DiseaseScaphycephaly

FREM1 NELL1

2.02e-03161242C0265534
DiseaseSynostotic Anterior Plagiocephaly

FREM1 NELL1

2.02e-03161242C2931150
DiseaseMetopic synostosis

FREM1 NELL1

2.02e-03161242C1860819
DiseaseBrachycephaly

FREM1 NELL1

2.29e-03171242C0221356
DiseaseVan Buchem disease

HSPG2 LRP5

2.29e-03171242C0432272
Diseasebanks of the superior temporal sulcus volume measurement

ATE1 SMARCA2

2.29e-03171242EFO_0010286
Diseaseskin sensitivity to sun

RXFP3 ADAMTS12

2.86e-03191242EFO_0004795
Diseaseulcerative colitis, Crohn's disease

TNFSF18 IL23R

3.17e-03201242EFO_0000384, EFO_0000729
DiseaseCraniosynostosis

FREM1 NELL1

3.17e-03201242C0010278
Diseasestroke

CHD3 ADAMTS12 MICAL2 FURIN

3.25e-031441244EFO_0000712
DiseaseManic Disorder

RELN PDE4B RIMS1

3.36e-03711243C0024713
DiseaseInfiltrating duct carcinoma of female breast

TRPM7 RPS6KC1

3.49e-03211242C3165106
Diseaseneuritic plaque measurement

EGLN3 ATE1 FREM1 RYR3 SMARCA2 RIMS1

3.64e-033491246EFO_0006798
DiseaseHodgkin Disease

RELN ITK

3.83e-03221242C0019829
DiseaseJT interval

CUL4A EGLN3 PDE4B LRIG3 BRWD1

4.03e-032481245EFO_0007885

Protein segments in the cluster

PeptideGeneStartEntry
TYLDKGSWLLGNINQ

TRHDE

671

Q9UKU6
LAANGWNLKNGDTLY

HSD3B2

166

P26439
LQQHGYATGLIGKWH

ARSD

136

P51689
SGHGFAQNQLVIWKY

CDC20

416

Q12834
WIQEERHLGKNNVLY

LINC01551

86

Q86U37
LGYGLQVGTVWINAH

ALDH16A1

441

Q8IZ83
VGGSEEYWLSQIQNH

ARC

231

Q7LC44
IVAWLAKQHNAYGGF

A2ML1

1221

A8K2U0
LHNIFLGIQYKFGWS

CLDN16

151

Q9Y5I7
QQAGYVTGIIGKWHL

ARSG

126

Q96EG1
NKYQINGLQAWLLTH

DHCR7

141

Q9UBM7
YLNKNWDAKLHGGIL

EGLN3

151

Q9H6Z9
NGYTALTWAARQGHK

ASZ1

181

Q8WWH4
GFIIQWNGNYKLAGT

ADAMTS12

756

P58397
FHKQDRGSGYLNWEQ

CAPN14

596

A8MX76
VQIGLDTGYWTAINH

ATP8B2

1026

P98198
RYAIQGLKWQHNEIT

MMP14

111

P50281
EIAWQALHLVNGYKL

RBM41

361

Q96IZ5
QAHAQVTWYKRGGSL

HSPG2

2271

P98160
QAHAQVTWYKRGGSL

HSPG2

2951

P98160
ATLEGWKLYHDPNVN

NUP107

376

P57740
GDSGQNAWLSYQLLK

PCDHB2

596

Q9Y5E7
GDSGQNAWLSYQLLK

PCDHB18P

541

Q96TA0
LRGGKSHYLALWNNE

RADX

181

Q6NSI4
GQWLESIGLPQYENH

ANKS1B

816

Q7Z6G8
QLGKDWTHQGITSLY

LPIN3

661

Q9BQK8
LAYQVHGLLKTGDNW

PTCD3

431

Q96EY7
SGDLGWLLNLFHNQI

LBP

171

P18428
QLGLGYANHGLQETW

LOXL3

461

P58215
GLLTDWGQRLHYDLQ

FANCF

276

Q9NPI8
HYDLQKGIWVGTESQ

FANCF

286

Q9NPI8
VAYWRKTHQGNLQTL

IRF1-AS1

21

Q8N8D9
QEYQQLHAVWEHKLG

WWC1

126

Q8IX03
HKGWFLYTLGQRANI

TRMU

256

O75648
FLVLQHAEGGKLWSY

RPS6KC1

401

Q96S38
DHNNLTEITKGWLYG

LRIG3

271

Q6UXM1
LFLYQWLANKENGTG

ENTPD8

56

Q5MY95
TILGKHLYWIDRQQQ

LRP5

1161

O75197
YSRLHKWAQGLAGNG

CALHM2

296

Q9HA72
VTGGNDHLVKVWDYN

CFAP52

561

Q8N1V2
QWADILTALYVLGHG

MGAT5B

316

Q3V5L5
TSYLGTHRQLKNIWG

PCNX2

1836

A6NKB5
LNYINQGVSHALTWK

IPO7

326

O95373
WYQALTHGLNEEQRK

IPO7

976

O95373
LGNIQIAHNLYWLLK

PIK3C2A

1001

O00443
NKWGLNIFNVAGYSH

PDE4B

346

Q07343
EVAYTGWLFQNHVLG

FKBP15

201

Q5T1M5
QHGQLYLWGTGLLQH

FREM1

1551

Q5H8C1
YLWGTGLLQHNFTQQ

FREM1

1556

Q5H8C1
QEYLNKHQNWVSGLS

PI4KA

1081

P42356
ELHQGQGLDIYWRDN

GGPS1

121

O95749
GRLLYIGQNEWTHVN

KMT2B

1596

Q9UMN6
LGQGADIWAYILQHV

HAUS5

36

O94927
QAWNGHYFILTDQKG

FOXRED2

156

Q8IWF2
KGNHYILNGNKFWIT

IVD

186

P26440
DQNGHKLYRSGDNWT

NELL1

696

Q92832
HQKEGYGLSWNPNLS

RBBP4

176

Q09028
ARQHALYIWEKSIGN

RBBP5

271

Q15291
QYSNNGGIQWHLLAE

RELN

1156

P78509
LIVQYSNDNGILWHL

RELN

1531

P78509
HLAQYWKDIAIAQRG

MORC2

446

Q9Y6X9
WYDKVGHQLIVNVLQ

RIMS1

751

Q86UR5
NTGYDVVLWKEINGH

GPRC6A

471

Q5T6X5
QYALANGDVWKVHEV

PPP1R16B

436

Q96T49
IWRGLQDLKQGHDYS

TP73

541

O15350
QDVLLEGHPSWKYLQ

IL34

106

Q6ZMJ4
ALHNIWLGRGQYGDK

C7orf25

126

Q9BPX7
GIVLHGYARWQDIQN

CHD3

1751

Q12873
HGEYWLGNKNLHFLT

FGL1

151

Q08830
LQIASHSGYVQIDWK

FUNDC1

86

Q8IVP5
DLNVKAAWAQGYTGH

FURIN

131

P09958
GQLLYSNLQHLKWNG

EHF

101

Q9NZC4
GGQQALLQHWSEYIK

CUL4A

331

Q13619
LQGGKKYLVWVQAAN

IL23R

186

Q5VWK5
VQIGHDNSGLYAKWL

DENND5A

1011

Q6IQ26
NDHVLKVWNSYTGQL

BRWD1

446

Q9NSI6
HQQYWLDGKIIAVGV

ATE1

341

O95260
ISNHDVILWLGDLNY

INPP5B

516

P32019
HVEGGTRLAYQWLKN

HEPACAM2

171

A8MVW5
GLYHCWNKNGRQVVQ

FAM187B

91

Q17R55
IQWFGDTRYALKHGQ

HOMEZ

401

Q8IX15
GNQGAKIIQSFLWYL

DGKZ

306

Q13574
QYCKEEVHIQGGIQW

C9orf57

106

Q5W0N0
QFINGINQGYKLLAW

SDK1

896

Q7Z5N4
YREGCAQGLQKWLHN

CD37

226

P11049
EQHFGLSLYWNQVQG

IL17RC

301

Q8NAC3
KLLTWCQQQTEGYQH

MICAL2

521

O94851
SGQFGLVHLGYWLNK

ITK

371

Q08881
LANHTGYIKVDWQRV

FUNDC2

121

Q9BWH2
GNLQLDCLAQGWKQY

RTP4

31

Q96DX8
QFWLGLYHSQKVLLG

RXFP3

261

Q9NSD7
NWLHIYLNNQDSGTK

RRN3

431

Q9NYV6
VWDHYKLTNQFLGGL

SYTL2

866

Q9HCH5
GEVYVWGSNKHGQLA

SERGEF

231

Q9UGK8
VHNWEYLGKQLQSEQ

ATP6V1H

461

Q9UI12
HKGRGQLVYSWTAGQ

TAPBPL

231

Q9BX59
NGTLKHYQLQGLEWM

SMARCA2

721

P51531
HGTGKWYELQDLQVT

USP39

521

Q53GS9
YEKARHQIQSWQGEL

SYNE1

4851

Q8NF91
GQNGDKWQYLHHELS

SYNE2

4446

Q8WXH0
VLQWTKHCDNVLYQG

RFX1

676

P22670
YQQNQVMHLSGGWGK

RGS22

926

Q8NE09
GSHKWRNNYLFGLIS

SPP2

156

Q13103
RNGLNVLELWHGVTY

THNSL2

96

Q86YJ6
LHSLTQWNGLINKYI

HERC2P3

866

Q9BVR0
NTAWNLYQELLGHDI

PRORP

261

O15091
QSKWLYVGTERGNTH

STXBP5L

166

Q9Y2K9
WLYIKHNQLQDGHER

SMARCD2

336

Q92925
IQNEHSYQVGSALLW

THAP7

226

Q9BT49
QYTLGHWQKLESARQ

PPOX

421

P50336
SGHKSVSWYQQVLGQ

TRBV5-5

46

A0A597
FQFWQGHTGIRYKEQ

TMPRSS13

186

Q9BYE2
LEGWKVYAGTSNLHQ

TMPRSS13

376

Q9BYE2
GDQLIYENWLVSGIH

ZP1

341

P60852
YENWLVSGIHIQKGP

ZP1

346

P60852
QHIASGLWVTYKAQD

RYR3

356

Q15413
HQVLKNNTYWGIILL

TNFSF18

156

Q9UNG2
DLNGKKYAWQGVALL

XRN2

636

Q9H0D6
ALSGAGQQHGSIYWK

XYLB

91

O75191
GQQHGSIYWKAGAQQ

XYLB

96

O75191
NWLHIYLNNQDSGTK

RRN3P1

56

Q2M238
QAAGGTHWSLLVYLQ

SENP8

96

Q96LD8
DHQNGIIQEYKIWCL

ROBO2

766

Q9HCK4
YRGNNWPGESKIHIQ

PKHD1L1

911

Q86WI1
YVGGKTCQILHWNFT

PKHD1L1

1276

Q86WI1
INWYFKGVDHITNIS

PKHD1L1

2896

Q86WI1
GQGLTARIWEQYLHD

SGSM1

586

Q2NKQ1
GHSARVWQVKLLENY

WDR6

256

Q9NNW5
WQKELLINHQGIYTN

ZNF582

181

Q96NG8
KYQGVSHFEWTQLLG

TMEM174

61

Q8WUU8
YWKGTNQNGNIHGEE

TRIM49D1

361

C9J1S8
GLINKGNWCYINATL

USP10

416

Q14694
LHHVGWAAQQGYELQ

SFMBT1

216

Q9UHJ3
GGGWQQEQFEHYKIN

SWAP70

151

Q9UH65
TLSNIQWYKQRPGGH

TRAV25

46

A0A0B4J276
QKYDRQLRLWGDHGQ

NAE1

11

Q13564
DIAKNHVFVYGQQWL

TRPM7

421

Q96QT4
HVFVYGQQWLVGSLE

TRPM7

426

Q96QT4
DWYKNQLGSQEVHLS

ZNF583

126

Q96ND8
GNEHLLNWARKEYGA

TGFBR3

156

Q03167
EHNNLTRVNKGWLYG

LRIG2

271

O94898