Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VIPR2 OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 TAS2R3 OR52L2P ADGRE4P TAS2R41 OR4K3 OR4C5 GPR148	1.15e-05	884	103	16	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 OR52L2P OR4K3 OR4C5 GPR148	1.40e-05	431	103	11	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VIPR2 OR1J1 TMEM63C FCRLA OR2T34 CLEC12A OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 TAS2R3 OR52L2P ADGRE4P TAS2R41 CHRNA10 OR4K3 OR4C5 GPR148	1.66e-05	1353	103	20	GO:0004888
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	2.64e-05	2	103	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	2.64e-05	2	103	2	GO:0047783
GeneOntologyMolecularFunction	type I interferon receptor binding	IFNA4 IFNA16 IFNW1	8.60e-05	17	103	3	GO:0005132
GeneOntologyMolecularFunction	retinol transmembrane transporter activity	ABCA4 STRA6	1.57e-04	4	103	2	GO:0034632
GeneOntologyMolecularFunction	alcohol transmembrane transporter activity	ABCA4 STRA6	7.23e-04	8	103	2	GO:0015665
GeneOntologyBiologicalProcess	detection of stimulus	ABCA4 OR1J1 OR2T34 PKDREJ OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 OR52L2P TAS2R41 KCNMB3 CHRNA10 OR4K3 OR4C5 GPR148	7.56e-08	722	101	17	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 OR52L2P TAS2R41 KCNMB3 OR4K3 OR4C5 GPR148	2.66e-07	524	101	14	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 OR52L2P TAS2R41 OR4K3 OR4C5 GPR148	7.10e-07	485	101	13	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 OR52L2P TAS2R41 CHRNA10 OR4K3 OR4C5 GPR148	9.33e-07	582	101	14	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 OR52L2P TAS2R41 OR4K3 OR4C5 GPR148	2.70e-06	547	101	13	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	ABCA4 OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 TAS2R3 OR52L2P TRPV2 TAS2R41 CHRNA10 OR4K3 OR4C5 GPR148 CLRN2	4.12e-06	1072	101	18	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 OR52L2P OR4K3 OR4C5 GPR148	8.77e-06	432	101	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 OR52L2P OR4K3 OR4C5 GPR148	1.74e-05	465	101	11	GO:0007608
GeneOntologyBiologicalProcess	T cell activation involved in immune response	MDK IFNA4 IFNA16 CCR2 IFNW1 KMT2A	8.92e-05	148	101	6	GO:0002286
GeneOntologyBiologicalProcess	retinol transport	ABCA4 STRA6	1.42e-04	4	101	2	GO:0034633
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	1.42e-04	4	101	2	GO:0002017
GeneOntologyBiologicalProcess	positive regulation of peptidyl-serine phosphorylation of STAT protein	IFNA4 IFNA16 IFNW1	1.42e-04	21	101	3	GO:0033141
GeneOntologyBiologicalProcess	regulation of peptidyl-serine phosphorylation of STAT protein	IFNA4 IFNA16 IFNW1	2.14e-04	24	101	3	GO:0033139
GeneOntologyBiologicalProcess	lymphocyte activation involved in immune response	MDK IFNA4 IFNA16 CCR2 IFNW1 RIF1 KMT2A	2.37e-04	251	101	7	GO:0002285
GeneOntologyBiologicalProcess	serine phosphorylation of STAT protein	IFNA4 IFNA16 IFNW1	3.42e-04	28	101	3	GO:0042501
GeneOntologyBiologicalProcess	isoprenoid transport	ABCA4 STRA6	3.52e-04	6	101	2	GO:0046864
GeneOntologyBiologicalProcess	terpenoid transport	ABCA4 STRA6	3.52e-04	6	101	2	GO:0046865
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	VIPR2 OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 TAS2R3 OR52L2P ADGRE4P AKAP13 TAS2R41 OR4K3 OR4C5 GPR148	4.14e-04	1395	101	17	GO:0007186
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	2.62e-05	2	72	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	2.62e-05	2	72	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	2.62e-05	2	72	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	2.62e-05	2	72	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	2.62e-05	2	72	2	MP:0011546
MousePheno	abnormal optic choroid morphology	ABCA4 LYST CCR2 STRA6	1.45e-04	52	72	4	MP:0005098
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	1.56e-04	4	72	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	1.56e-04	4	72	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	1.56e-04	4	72	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	1.56e-04	4	72	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	1.56e-04	4	72	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	2.59e-04	5	72	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	3.87e-04	6	72	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	3.87e-04	6	72	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	3.87e-04	6	72	2	MP:0009078
Domain	BEACH_dom	WDR81 LYST WDFY3 LRBA	1.03e-07	9	102	4	IPR000409
Domain	BEACH	WDR81 LYST WDFY3 LRBA	1.03e-07	9	102	4	PS50197
Domain	Beach	WDR81 LYST WDFY3 LRBA	1.03e-07	9	102	4	PF02138
Domain	-	WDR81 LYST WDFY3 LRBA	1.03e-07	9	102	4	1.10.1540.10
Domain	Beach	WDR81 LYST WDFY3 LRBA	1.03e-07	9	102	4	SM01026
Domain	PH_BEACH	LYST WDFY3 LRBA	3.13e-06	6	102	3	PF14844
Domain	PH-BEACH_dom	LYST WDFY3 LRBA	8.68e-06	8	102	3	IPR023362
Domain	-	LYST WDFY3 LRBA	8.68e-06	8	102	3	2.30.29.40
Domain	PH_BEACH	LYST WDFY3 LRBA	8.68e-06	8	102	3	PS51783
Domain	ARM-type_fold	TRPC4AP BTAF1 PPP6R1 LYST RIF1 THADA MROH8 WDFY3 LRBA PPP6R3	1.65e-05	339	102	10	IPR016024
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	2.95e-05	2	102	2	IPR002399
Domain	SAPS	PPP6R1 PPP6R3	8.83e-05	3	102	2	IPR007587
Domain	SAPS	PPP6R1 PPP6R3	8.83e-05	3	102	2	PF04499
Domain	Interferon_alpha/beta/delta	IFNA4 IFNA16 IFNW1	1.02e-04	17	102	3	IPR000471
Domain	Interferon	IFNA4 IFNA16 IFNW1	1.02e-04	17	102	3	PF00143
Domain	IFabd	IFNA4 IFNA16 IFNW1	1.02e-04	17	102	3	SM00076
Domain	INTERFERON_A_B_D	IFNA4 IFNA16 IFNW1	1.02e-04	17	102	3	PS00252
Domain	-	HSPG2 LAMA5 FAT1 WDFY3 LRBA	1.73e-04	95	102	5	2.60.120.200
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A1 ATP6V0A2	1.76e-04	4	102	2	IPR026028
Domain	V_ATPase_I	ATP6V0A1 ATP6V0A2	1.76e-04	4	102	2	PF01496
Domain	V-ATPase_116kDa_su	ATP6V0A1 ATP6V0A2	1.76e-04	4	102	2	IPR002490
Domain	DUF4704	WDFY3 LRBA	2.92e-04	5	102	2	IPR031570
Domain	DUF4704	WDFY3 LRBA	2.92e-04	5	102	2	PF15787
Domain	LAMININ_IVA	HSPG2 LAMA5	8.09e-04	8	102	2	PS51115
Domain	Laminin_B	HSPG2 LAMA5	8.09e-04	8	102	2	PF00052
Domain	LamB	HSPG2 LAMA5	8.09e-04	8	102	2	SM00281
Domain	Laminin_IV	HSPG2 LAMA5	8.09e-04	8	102	2	IPR000034
Domain	LAM_G_DOMAIN	HSPG2 LAMA5 FAT1	1.16e-03	38	102	3	PS50025
Domain	Ubiquitin_CS	UBB UBC	1.29e-03	10	102	2	IPR019954
Domain	Laminin_G_2	HSPG2 LAMA5 FAT1	1.35e-03	40	102	3	PF02210
Domain	GPCR_Rhodpsn	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 TAS2R3 OR4C5 GPR148	1.39e-03	692	102	11	IPR000276
Domain	Olfact_rcpt	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 OR4C5	1.40e-03	393	102	8	IPR000725
Domain	Ubiquitin	UBB UBC	1.57e-03	11	102	2	IPR019956
Domain	LamG	HSPG2 LAMA5 FAT1	1.78e-03	44	102	3	SM00282
Domain	-	IFNA4 IFNA16 IFNW1	2.57e-03	50	102	3	1.20.1250.10
Domain	4_helix_cytokine_core	IFNA4 IFNA16 IFNW1	2.72e-03	51	102	3	IPR012351
Domain	Cyt_P450_CS	CYP4Z1 CYP11B1 CYP11B2	3.04e-03	53	102	3	IPR017972
Domain	7TM_GPCR_Srsx	OR2T34 OR1L3 OR2T3 CCR2	3.32e-03	112	102	4	SM01381
Domain	CYTOCHROME_P450	CYP4Z1 CYP11B1 CYP11B2	3.74e-03	57	102	3	PS00086
Domain	7tm_1	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 OR4C5 GPR148	3.90e-03	677	102	10	PF00001
Domain	-	CYP4Z1 CYP11B1 CYP11B2	3.92e-03	58	102	3	1.10.630.10
Domain	Laminin_G	HSPG2 LAMA5 FAT1	3.92e-03	58	102	3	IPR001791
Domain	p450	CYP4Z1 CYP11B1 CYP11B2	3.92e-03	58	102	3	PF00067
Domain	G_PROTEIN_RECEP_F1_1	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 OR4C5 GPR148	4.23e-03	685	102	10	PS00237
Domain	aa-tRNA-synth_II	DARS1 SARS2	4.27e-03	18	102	2	IPR006195
Domain	AA_TRNA_LIGASE_II	DARS1 SARS2	4.27e-03	18	102	2	PS50862
Domain	Cyt_P450	CYP4Z1 CYP11B1 CYP11B2	4.32e-03	60	102	3	IPR001128
Domain	G_PROTEIN_RECEP_F1_2	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 CCR2 OR51A7 OR4C5 GPR148	4.50e-03	691	102	10	PS50262
Pathway	REACTOME_SENSORY_PERCEPTION	HSPG2 ABCA4 OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 TAS2R3 TAS2R41 STRA6 CHRNA10 OR4K3 OR4C5	1.22e-06	636	76	15	M41834
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	IFNA4 IFNA16 UBB UBC	3.20e-05	34	76	4	MM15631
Pathway	REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES	IFNA4 IFNA16 UBB UBC	3.60e-05	35	76	4	M48246
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_SEQUESTOSOME_1_LIKE_RECEPTOR	UBB UBC WDFY3	5.25e-05	14	76	3	M47975
Pathway	REACTOME_ER_QUALITY_CONTROL_COMPARTMENT_ERQC	UBB UBC	1.71e-04	4	76	2	MM15591
Pathway	REACTOME_RSV_HOST_INTERACTIONS	HSPG2 IFNA4 IFNA16 UBB UBC	1.83e-04	98	76	5	M48247
Pathway	REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	MDK UBB UBC	2.15e-04	22	76	3	M27210
Pathway	REACTOME_IRON_UPTAKE_AND_TRANSPORT	ATP6V0A1 UBB UBC ATP6V0A2	2.32e-04	56	76	4	MM15638
Pathway	REACTOME_IRON_UPTAKE_AND_TRANSPORT	ATP6V0A1 UBB UBC ATP6V0A2	2.65e-04	58	76	4	M962
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	IFNA4 IFNA16 IFNW1	2.81e-04	24	76	3	M47908
Pathway	KEGG_MEDICUS_REFERENCE_UCHL1_MEDIATED_HYDROLYSIS	UBB UBC	2.84e-04	5	76	2	M49036
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	2.84e-04	5	76	2	M47522
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPC4AP ATP6V0A1 UBB UBC TRPV2 ATP6V0A2	3.69e-04	176	76	6	MM15718
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1J1 OR2T34 OR1L3 OR1J2 OR2T3 OR10G6 OR51A7 OR4K3 OR4C5	3.92e-04	417	76	9	M4072
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPC4AP ATP6V0A1 UBB UBC TRPV2 ATP6V0A2	4.54e-04	183	76	6	M997
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	HSPG2 IFNA4 IFNA16 UBB UBC	4.69e-04	120	76	5	M48233
Pathway	REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES	IFNA4 IFNA16 NUP205 UBB UBC	5.86e-04	126	76	5	M45009
Pathway	REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS	UBB UBC	5.92e-04	7	76	2	MM15593
Pathway	REACTOME_CALNEXIN_CALRETICULIN_CYCLE	UBB UBC	5.92e-04	7	76	2	MM15592
Pathway	REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM	UBB UBC	5.92e-04	7	76	2	M29822
Pathway	REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS	UBB UBC	5.92e-04	7	76	2	M41737
Pathway	REACTOME_SIGNALING_BY_NOTCH2	MDK UBB UBC	7.31e-04	33	76	3	M604
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	IFNA4 IFNA16 UBB UBC	8.23e-04	78	76	4	M973
Pathway	KEGG_REGULATION_OF_AUTOPHAGY	IFNA4 IFNA16 ULK1	8.71e-04	35	76	3	M6382
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	IFNA4 IFNA16 UBB UBC	9.93e-04	82	76	4	M1002
Pathway	REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1	UBB UBC	1.01e-03	9	76	2	M27732
Pathway	REACTOME_INLA_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELLS	UBB UBC	1.01e-03	9	76	2	M27781
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	UBB UBC	1.01e-03	9	76	2	M26930
Pathway	REACTOME_REGULATION_OF_PTEN_LOCALIZATION	UBB UBC	1.01e-03	9	76	2	M27814
Pathway	REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1	UBB UBC	1.01e-03	9	76	2	MM14676
Pathway	REACTOME_PREVENTION_OF_PHAGOSOMAL_LYSOSOMAL_FUSION	UBB UBC	1.01e-03	9	76	2	M29819
Pathway	REACTOME_MYOCLONIC_EPILEPSY_OF_LAFORA	UBB UBC	1.01e-03	9	76	2	M27276
Pathway	REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1	UBB UBC	1.01e-03	9	76	2	MM15482
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	UBB UBC	1.01e-03	9	76	2	MM14535
Pathway	WP_INTERFERONMEDIATED_SIGNALING	IFNA4 IFNA16 IFNW1	1.03e-03	37	76	3	M39785
Pathway	REACTOME_SARS_COV_2_INFECTION	HSPG2 IFNA4 IFNA16 NUP205 UBB UBC ZDHHC11	1.13e-03	299	76	7	M41727
Pathway	REACTOME_MITOPHAGY	UBB UBC ULK1	1.20e-03	39	76	3	M27418
Pathway	REACTOME_REGULATION_OF_PTEN_LOCALIZATION	UBB UBC	1.26e-03	10	76	2	MM15539
Pathway	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	UBB UBC	1.26e-03	10	76	2	MM14849
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.26e-03	10	76	2	M27076
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	UBB UBC	1.26e-03	10	76	2	MM15647
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	UBB UBC	1.26e-03	10	76	2	M27925
Pathway	REACTOME_MITOPHAGY	UBB UBC ULK1	1.39e-03	41	76	3	MM15166
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION	UBB UBC	1.53e-03	11	76	2	M48241
Pathway	REACTOME_REGULATION_OF_BACH1_ACTIVITY	UBB UBC	1.53e-03	11	76	2	M41833
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	UBB UBC	1.53e-03	11	76	2	M29827
Pathway	REACTOME_PEXOPHAGY	UBB UBC	1.53e-03	11	76	2	M29846
Pathway	REACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX	UBB UBC	1.53e-03	11	76	2	M27885
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	UBB UBC	1.53e-03	11	76	2	MM15668
Pathway	REACTOME_PEXOPHAGY	UBB UBC	1.53e-03	11	76	2	MM15673
Pathway	REACTOME_REGULATION_OF_BACH1_ACTIVITY	UBB UBC	1.53e-03	11	76	2	MM15686
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.53e-03	11	76	2	MM14750
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP4Z1 CYP11B1 CYP11B2	1.59e-03	43	76	3	MM15873
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	UBB UBC	1.83e-03	12	76	2	M27577
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	UBB UBC	1.83e-03	12	76	2	MM15288
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.83e-03	12	76	2	MM14749
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	UBB UBC	1.83e-03	12	76	2	MM14550
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPC4AP UBB UBC TRPV2	1.99e-03	99	76	4	MM14910
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	UBB UBC ULK1	2.06e-03	47	76	3	MM15179
Pathway	REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES	UBB UBC	2.15e-03	13	76	2	MM14827
Pathway	REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL	UBB UBC	2.15e-03	13	76	2	MM14828
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	UBB UBC	2.15e-03	13	76	2	MM15280
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	UBB UBC	2.15e-03	13	76	2	M549
Pathway	REACTOME_SUPPRESSION_OF_PHAGOSOMAL_MATURATION	UBB UBC	2.15e-03	13	76	2	M29823
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	UBB UBC	2.15e-03	13	76	2	MM14931
Pathway	REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES	UBB UBC	2.15e-03	13	76	2	M14582
Pathway	REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7	UBB UBC	2.15e-03	13	76	2	M27884
Pathway	REACTOME_RETINOID_CYCLE_DISEASE_EVENTS	ABCA4 STRA6	2.15e-03	13	76	2	M29612
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING	UBB UBC	2.15e-03	13	76	2	M967
Pathway	REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL	UBB UBC	2.15e-03	13	76	2	M736
Pathway	REACTOME_DISEASES_OF_METABOLISM	HSPG2 MUC21 CYP11B1 CYP11B2 UBB UBC	2.27e-03	250	76	6	M27554
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	UBB UBC	2.50e-03	14	76	2	M48239
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	UBB UBC	2.50e-03	14	76	2	MM14826
Pathway	REACTOME_GLYCOGEN_SYNTHESIS	UBB UBC	2.50e-03	14	76	2	M27247
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.50e-03	14	76	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.50e-03	14	76	2	M46453
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FLT3	UBB UBC	2.50e-03	14	76	2	MM15682
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	UBB UBC	2.50e-03	14	76	2	M935
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	UBB UBC	2.50e-03	14	76	2	MM15642
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPC4AP UBB UBC TRPV2	2.56e-03	106	76	4	M27200
Pathway	REACTOME_INLB_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELL	UBB UBC	2.88e-03	15	76	2	M27774
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	UBB UBC	2.88e-03	15	76	2	MM17228
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	UBB UBC	2.88e-03	15	76	2	MM14875
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	UBB UBC	2.88e-03	15	76	2	M27229
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FLT3	UBB UBC	2.88e-03	15	76	2	M41735
Pathway	REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER	UBB UBC	2.88e-03	15	76	2	M27202
Pathway	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE	UBB UBC	2.88e-03	15	76	2	MM15175
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	UBB UBC	2.88e-03	15	76	2	MM15645
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES	CYP11B1 CYP11B2 PLPP6 SCD	3.02e-03	111	76	4	M48065
Pathway	KEGG_VIBRIO_CHOLERAE_INFECTION	KDELR3 ATP6V0A1 ATP6V0A2	3.07e-03	54	76	3	M17906
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	UBB UBC	3.28e-03	16	76	2	M27761
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	UBB UBC	3.28e-03	16	76	2	M27567
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	UBB UBC	3.28e-03	16	76	2	M7257
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	UBB UBC	3.28e-03	16	76	2	MM14873
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	UBB UBC	3.28e-03	16	76	2	MM15506
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	UBB UBC	3.28e-03	16	76	2	M627
Pathway	REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX	UBB UBC	3.28e-03	16	76	2	M1000
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	UBB UBC	3.28e-03	16	76	2	MM14903
Pathway	REACTOME_ASSEMBLY_OF_THE_HIV_VIRION	UBB UBC	3.28e-03	16	76	2	M27033
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	3.28e-03	16	76	2	M39815
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	DARS1 BTAF1 PPP6R1 NDUFS2 RIF1 THADA SCD TUBGCP3 CNOT1 ATP6V0A2 PPP6R3	5.03e-06	657	105	11	36180527
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 LAMA5 BTAF1 PPP6R1 LYST FAT1 THADA SARS2 SYNJ1 AKAP13 ULK1 WDFY3 LRBA HAS3	6.14e-06	1105	105	14	35748872
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	9.03e-06	2	105	2	23150505
Pubmed	Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.	UBB UBC	9.03e-06	2	105	2	29130934
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	9.03e-06	2	105	2	21164264
Pubmed	Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product.	UBB UBC	9.03e-06	2	105	2	9644242
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	9.03e-06	2	105	2	8645611
Pubmed	The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.	UBB UBC	9.03e-06	2	105	2	20491623
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	9.03e-06	2	105	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	9.03e-06	2	105	2	20634641
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z1 CYP4Z2P	9.03e-06	2	105	2	28236635
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	9.03e-06	2	105	2	1303253
Pubmed	Hybrid troponin reconstituted from vertebrate and arthropod subunits.	UBB UBC	9.03e-06	2	105	2	124018
Pubmed	Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.	UBB UBC	9.03e-06	2	105	2	32705536
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	9.03e-06	2	105	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	9.03e-06	2	105	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	9.03e-06	2	105	2	26047574
Pubmed	Structure of a new crystal form of tetraubiquitin.	UBB UBC	9.03e-06	2	105	2	11173499
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	9.03e-06	2	105	2	26324851
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z1 CYP4Z2P	9.03e-06	2	105	2	15059886
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	9.03e-06	2	105	2	7669222
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	9.03e-06	2	105	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	9.03e-06	2	105	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	2256920
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	9.03e-06	2	105	2	20708777
Pubmed	Ubiquitination of human immunodeficiency virus type 1 Gag is highly dependent on Gag membrane association.	UBB UBC	9.03e-06	2	105	2	17609272
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	9.03e-06	2	105	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	9.03e-06	2	105	2	16396990
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	9.03e-06	2	105	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	9.03e-06	2	105	2	1518866
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	9.03e-06	2	105	2	23761669
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	9.03e-06	2	105	2	2592361
Pubmed	Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells.	UBB UBC	9.03e-06	2	105	2	8917096
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	9.03e-06	2	105	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	9.03e-06	2	105	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	9.03e-06	2	105	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	9.03e-06	2	105	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	9.03e-06	2	105	2	15731365
Pubmed	The emerging complexity of protein ubiquitination.	UBB UBC	9.03e-06	2	105	2	19754430
Pubmed	Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells.	UBB UBC	9.03e-06	2	105	2	2820408
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	9.03e-06	2	105	2	17651452
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	34743356
Pubmed	Structure of ubiquitin refined at 1.8 A resolution.	UBB UBC	9.03e-06	2	105	2	3041007
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	20808686
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z1 CYP4Z2P	9.03e-06	2	105	2	25701119
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	9.03e-06	2	105	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	9.03e-06	2	105	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	9.03e-06	2	105	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	9.03e-06	2	105	2	26066897
Pubmed	The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.	UBB UBC	9.03e-06	2	105	2	2988935
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	9.03e-06	2	105	2	18651133
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	9.03e-06	2	105	2	22083159
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	9.03e-06	2	105	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	9.03e-06	2	105	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	9.03e-06	2	105	2	38341019
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	9.03e-06	2	105	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	9.03e-06	2	105	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	9.03e-06	2	105	2	19820005
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	9.03e-06	2	105	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	9.03e-06	2	105	2	15062555
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	9.03e-06	2	105	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	9.03e-06	2	105	2	17075029
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	9.03e-06	2	105	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	9.03e-06	2	105	2	17296872
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	9.03e-06	2	105	2	18039983
Pubmed	Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus.	UBB UBC	9.03e-06	2	105	2	9504932
Pubmed	Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.	UBB UBC	9.03e-06	2	105	2	8166633
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	9.03e-06	2	105	2	19029289
Pubmed	Lineage-specific homogenization of the polyubiquitin gene among human and great apes.	UBB UBC	9.03e-06	2	105	2	14745543
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	9.03e-06	2	105	2	15522937
Pubmed	Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands.	IFNA4 IFNA16 CCR2	9.50e-06	14	105	3	19620305
Pubmed	Characterization of the murine alpha interferon gene family.	IFNA4 IFNA16 IFNW1	9.50e-06	14	105	3	15254193
Pubmed	Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.	IFNA4 IFNA16 IFNW1	2.50e-05	19	105	3	1385305
Pubmed	Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.	UBB UBC	2.70e-05	3	105	2	20826778
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	2.70e-05	3	105	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	2.70e-05	3	105	2	16118390
Pubmed	Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branching.	UBB UBC	2.70e-05	3	105	2	17067581
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	2.70e-05	3	105	2	17984374
Pubmed	Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.	UBB UBC	2.70e-05	3	105	2	9488668
Pubmed	Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.	UBC ULK1	2.70e-05	3	105	2	25723488
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	2.70e-05	3	105	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	2.70e-05	3	105	2	33271253
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	2.70e-05	3	105	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	2.70e-05	3	105	2	11932209
Pubmed	A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins.	UBB UBC	2.70e-05	3	105	2	12207904
Pubmed	CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex.	TUBGCP3 CDK5RAP2	2.70e-05	3	105	2	17959831
Pubmed	Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.	ATP6V0A1 ATP6V0A2	2.70e-05	3	105	2	10702241
Pubmed	Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.	UBB UBC	2.70e-05	3	105	2	15826667
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	2.70e-05	3	105	2	21467193
Pubmed	Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.	UBB UBC	2.70e-05	3	105	2	25701757
Pubmed	Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.	LLGL1 KMT2A	2.70e-05	3	105	2	37587260
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	2.70e-05	3	105	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	2.70e-05	3	105	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	2.70e-05	3	105	2	28355486
Pubmed	From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation.	ATP6V0A1 ATP6V0A2	2.70e-05	3	105	2	12672822
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	2.70e-05	3	105	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	2.70e-05	3	105	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	2.70e-05	3	105	2	8111631
Interaction	GPR182 interactions	KDELR3 BTAF1 PPP6R1 PLPP6 NUP205 JPH1 RIF1 THADA SCD TUBGCP3 WDFY3 TAP2	1.36e-06	455	94	12	int:GPR182
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	OR1J1 OR1L3 OR1J2 CDK5RAP2 ASTN2	1.81e-05	138	106	5	chr9q33
Cytoband	9p22	IFNA4 IFNA16 IFNW1	2.65e-05	25	106	3	9p22
Cytoband	12q24.3	UBC ULK1	7.87e-05	6	106	2	12q24.3
Cytoband	9q33.2	OR1J1 OR1L3 CDK5RAP2	1.03e-04	39	106	3	9q33.2
Cytoband	8q21	CYP11B1 JPH1	3.43e-04	12	106	2	8q21
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 LYST WDFY3 LRBA	3.03e-08	9	73	4	1230
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	4.81e-05	3	73	2	1007
GeneFamily	Protein phosphatase 6 regulatory subunits	PPP6R1 PPP6R3	2.39e-04	6	73	2	699
GeneFamily	Interferons	IFNA4 IFNA16 IFNW1	2.88e-04	32	73	3	598
GeneFamily	Olfactory receptors, family 1	OR1J1 OR1L3 OR1J2	5.60e-04	40	73	3	147
GeneFamily	Aminoacyl tRNA synthetases, Class II	DARS1 SARS2	2.63e-03	19	73	2	132
GeneFamily	V-type ATPases	ATP6V0A1 ATP6V0A2	3.85e-03	23	73	2	415
GeneFamily	WD repeat domain containing	WDR81 LYST LLGL1 WDFY3 LRBA	4.14e-03	262	73	5	362
Drug	dihydroflavonol	ATP6V0A1 LYST TAP2 ATP6V0A2	3.03e-06	23	101	4	CID000147806
Drug	HCNO	ATP6V0A1 SCD ATP6V0A2	1.81e-05	12	101	3	CID000521293
Drug	cyadox	CYP11B1 CYP11B2	1.95e-05	2	101	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	1.95e-05	2	101	2	ctd:C042509
Drug	UCH-L3 inhibitor	UBB UBC	1.95e-05	2	101	2	CID002729042
Drug	4 pN	UBB UBC GZMM	2.35e-05	13	101	3	CID000078607
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	9.83e-06	2	93	2	DOID:0050891 (is_marker_for)
Disease	Wrinkly skin syndrome	KMT2A ATP6V0A2	9.83e-06	2	93	2	C0406587
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	9.83e-06	2	93	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	2.94e-05	3	93	2	DOID:0050811 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	LYST WDFY3	5.87e-05	4	93	2	DOID:2935 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	9.77e-05	5	93	2	DOID:446 (is_implicated_in)
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A1 ATP6V0A2	9.77e-05	5	93	2	DOID:0110942 (implicated_via_orthology)
Disease	Conn Syndrome	CYP11B1 CYP11B2	1.46e-04	6	93	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	1.46e-04	6	93	2	C0020428
Disease	brain infarction (biomarker_via_orthology)	CYP11B1 CYP11B2 MEIS2	1.54e-04	33	93	3	DOID:3454 (biomarker_via_orthology)
Disease	10-undecenoate 11:1n1 measurement	CYP4Z1 CYP4Z2P	2.04e-04	7	93	2	EFO_0021099
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	2.04e-04	7	93	2	EFO_0801973
Disease	exfoliation syndrome (is_marker_for)	PON1 STRA6	2.72e-04	8	93	2	DOID:13641 (is_marker_for)
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A1 ATP6V0A2	2.72e-04	8	93	2	DOID:14219 (implicated_via_orthology)
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	3.49e-04	9	93	2	EFO_0802936
Disease	gallstones	KDELR3 AP1S3 HID1 LRBA	3.86e-04	108	93	4	EFO_0004210
Disease	androstenedione measurement	CYP11B1 CYP11B2	4.35e-04	10	93	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	5.31e-04	11	93	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	5.31e-04	11	93	2	EFO_0801461
Disease	open-angle glaucoma (is_implicated_in)	PON1 MEIS2	6.35e-04	12	93	2	DOID:1067 (is_implicated_in)
Disease	Kuhnt-Junius degeneration (is_marker_for)	PON1 CCR2	8.72e-04	14	93	2	DOID:10873 (is_marker_for)
Disease	teratocarcinoma-derived growth factor 1 measurement	CCR2 KMT2A	1.15e-03	16	93	2	EFO_0008297
Disease	non-Hodgkin lymphoma (is_implicated_in)	PON1 KMT2A	1.30e-03	17	93	2	DOID:0060060 (is_implicated_in)
Disease	Primary microcephaly	TUBGCP3 CDK5RAP2	2.18e-03	22	93	2	C0431350
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	2.81e-03	25	93	2	EFO_0021854
Disease	macular degeneration (is_marker_for)	PON1 CCR2	3.04e-03	26	93	2	DOID:4448 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGLRSHHLSLGLLLL	CHRNA10	1	Q9GZZ6
LQELMAHPFLLLILL	CYP4Z2P	6	Q8N1L4
SIFLLTIFIMHGRIL	ABCA4	711	P78363
MFLLLALLTELGRLQ	ADAM18	1	Q9Y3Q7
RMAQLRLVLGLHTLD	GZMM	71	P51124
MLLEGLHLFLTVRNL	ADGRE4P	271	Q86SQ3
TLMHFAVRLGLLRLT	AKAP13	166	Q12802
HISVMGGLIALLLLL	ASTN2	206	O75129
LHSLLMEIQALRLQL	CDK5RAP2	1591	Q96SN8
HLLMALAGIDTLLIR	HSPG2	1076	P98160
RRDLEHLMLLIGELY	NUP205	436	Q92621
MHFLTGQGRLLSLLD	LLGL1	81	Q15334
LLAVIMIFGLLQAHG	PLA2G2A	6	P14555
MIHFILLFSRQGKLR	AP1S3	1	Q96PC3
MGRHLALLLLLLLLF	FAT1	1	Q14517
GNLLIMLLIQLDSHL	OR1J2	41	Q8NGS2
VLLLHALLMRHRALS	LDOC1	6	O95751
LLDRMVHLLSRGYVL	NELFCD	496	Q8IXH7
GNVLLMFGLLLHLEA	MUC21	6	Q5SSG8
MQHRGFLLLTLLALL	MDK	1	P21741
ALHGLTMLRTLLLEH	LRRC53	76	A6NM62
LMIQAIQVLRFHLLE	MEIS2	146	O14770
MLLNIGLAILFVHFL	JPH1	646	Q9HDC5
MLFFSILRLGSLHAI	TMEM63C	671	Q9P1W3
ILGDLSHLLAMILLL	KDELR3	6	O43731
LIMSLDRFLAIHNPL	OR51A7	116	Q8NH64
MFFLHLLGGAEIVLL	OR4K3	101	Q96R72
GHGLFSLLAERLMLQ	LRBA	761	P50851
LLLGQGDFIRHLMDL	TUBGCP3	566	Q96CW5
LRFLRTNTLLGHLMG	LAMA5	261	O15230
GNLLIMLLIQLDSHL	OR1J1	41	Q8NGS3
LMALTGNALLILLIH	OR2T34	41	Q8NGX1
LMALTGNALLILLIH	OR2T3	41	Q8NH03
LRFQRLGHLVALMAL	MROH8	246	Q9H579
LMLFELIHGLQDLSI	OOSP4A	11	A0A2R8YFL7
LLIMERLHRDLYTGL	DSTYK	731	Q6XUX3
RVLFGEITRLLNHIM	NDUFS2	171	O75306
LILMAISFLQLHPRI	TENT4A	386	Q5XG87
MGRGVRVLLLLSLLH	NOTUM	1	Q6P988
HLLVTNELLAGVLLM	QTRT2	366	Q9H974
GLLSRNTLVLLHQMR	IFNW1	31	P05000
LLLLGLAMVAHGLLR	IGLL5	26	B9A064
VLAMDALHRQVLPFL	BTAF1	1486	O14981
VRVLLGHLLMELREL	FCRLA	331	Q7L513
NILLSDLAYILLHML	GPR148	91	Q8TDV2
LGRRLAEAEMLLLLH	CYP11B1	451	P15538
FHTIMRNILGLVLPL	CCR2	201	P41597
ALIQRMLFRTVLHLL	LYST	321	Q99698
LIVGMVRLTQHLSLL	KCNMB3	226	Q9NPA1
GLRMLGILHDAVVFL	KMT2A	3716	Q03164
LLIQSLFAFLEHRRM	HAS3	56	O00219
LGRRLAEAEMLLLLH	CYP11B2	451	P19099
MALRHLALLAGLLVG	C1orf159	1	Q96HA4
LSFHLLFGLEIRMRR	C9orf57	11	Q5W0N0
MLEGVEHLLLLLLLT	OR10G6	1	Q8NH81
LVTLMGNLLIILAIH	OR1L3	36	Q8NH93
HIGMVVLVRGLLLLI	OR52L2P	161	Q8NGH6
VGGFLHALIQMLLIV	OR4C5	171	Q8NGB2
LELFLLIHNLDSQML	ORC2	386	Q13416
FLVSIMLLINSLRRH	TAS2R41	196	P59536
FLSLQMEILTELGLH	SARS2	371	Q9NP81
RHPSMFLLLLVLERL	THADA	1316	Q6YHU6
LGLHQTFLLMLIIGR	TMEM26	146	Q6ZUK4
DQMFLLKRGLLEHIL	TRPC4AP	551	Q8TEL6
ALTLLGMGLALFRNH	PON1	6	P27169
SLLIFSLGRHTRQML	TAS2R3	201	Q9NYW6
LRLNLGDTMLHYLVL	SYNJ1	66	O43426
SIQLLGLEMLLHFLL	RIF1	426	Q5UIP0
RALILLAQMGRISHF	IFNA16	36	P05015
VDHIMRIILGFLLFL	PKDREJ	2046	Q9NTG1
VGLMHIGVFILLLLS	HID1	416	Q8IV36
YLLVRRVLHLGVQML	TAP2	376	Q03519
IGLERVTMLFLGLHN	DARS1	471	P14868
RALILLAQMGRISHF	IFNA4	36	P05014
EMVHGLLRISLLYLA	RHBDL1	276	O75783
FLVLMPVLHGRNLLL	STRA6	451	Q9BX79
FLLFVLENMLGLLRH	SLC39A5	296	Q6ZMH5
KELNAGLHVMILLLL	CLRN2	91	A0PK11
GLHVMILLLLFLALA	CLRN2	96	A0PK11
LLLLIGLGVLASMFH	CLEC12A	51	Q5QGZ9
HRIFIMLLLELNAPE	CNOT1	1991	A5YKK6
LQELMAHPFLLLILL	CYP4Z1	6	Q86W10
EFLILLHMLQRKLGR	SPATA4	211	Q8NEY3
NALGLMHLRRLFTEL	WDFY3	21	Q8IZQ1
FMEGLSRHLILNLIL	TMEM131	916	Q92545
LHPIIQIDRSFMLLI	SERPINA7	381	P05543
LHFRGMVLLLLLAYV	TRPV2	616	Q9Y5S1
HRLSVRQGLALLLLM	SLC35A4	136	Q96G79
IGKVLILHTDMLLQR	TEX11	371	Q8IYF3
IILMSLLHLGALYGI	SCD	76	O00767
SRQLLTMHGTFVILL	TMEM114	96	B3SHH9
ILFLIVMHRSLVGLD	RAB11FIP2	81	Q7L804
TLHLVLRLRGGMQIF	UBB	66	P0CG47
AGREVLMNLLFALLL	PLPP6	161	Q8IY26
MSRFILNHLVLAIPL	PLPP6	221	Q8IY26
HIGTSAIMDLLLRLL	PPP6R1	156	Q9UPN7
LVEGLYLHTLLVAML	VIPR2	221	P41587
IGMLVLLLDFLGLVH	ZDHHC11	236	Q9H8X9
LIMEGLSAFLHALRL	ATP6V0A1	791	Q93050
LLRGVLHMLDALLVH	TMEM89	121	A2RUT3
RVVKMDLGLLFLRLH	SEMA3E	631	O15041
LFHQRLFGQLLRLKM	TMEM117	86	Q9H0C3
TLHLVLRLRGGMQIF	UBC	66	P0CG48
LHLVLRLRGGMQIFV	UBC	371	P0CG48
TLHLVLRLRGGMQIF	UBC	446	P0CG48
HIGTSAIMDLLLRLL	PPP6R3	156	Q5H9R7
RLFLQQIAGAMRLLH	ULK1	116	O75385
LMVRLGLQAFLTHLL	WDR81	991	Q562E7
LIMEGLSAFLHAIRL	ATP6V0A2	806	Q9Y487
HRLNLLLLRTVGMAN	VPS13D	1171	Q5THJ4