Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

2.05e-052912GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

2.05e-052912GO:0044017
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

6.14e-053912GO:0043993
GeneOntologyBiologicalProcessglossopharyngeal nerve morphogenesis

HOXA3 HOXB3 HOXD3

3.10e-074893GO:0021615
GeneOntologyBiologicalProcessglossopharyngeal nerve development

HOXA3 HOXB3 HOXD3

7.72e-075893GO:0021563
GeneOntologyCellularComponentlysosomal HOPS complex

VPS39 VPS41

1.79e-052892GO:1902501
GeneOntologyCellularComponentvacuolar HOPS complex

VPS39 VPS41

1.79e-052892GO:1902500
GeneOntologyCellularComponentcyclin E1-CDK2 complex

CCNE1 CCNE2

5.36e-053892GO:0097134
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

2.31e-052252HP:0008107
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

2.31e-052252HP:0034227
HumanPhenoHigh axial triradius

CREBBP EP300

2.31e-052252HP:0001042
HumanPhenoAbnormal cardiac atrium morphology

ADK SOX11 GTF2I MTX2 MED23 CDC42BPB CREBBP EP300 LARP7 DNAH1 MYBPC3

6.76e-056172511HP:0005120
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

6.92e-053252HP:0008752
HumanPhenoPhobia

CREBBP EP300

6.92e-053252HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

6.92e-053252HP:0000756
HumanPhenoHumoral immunodeficiency

CREBBP EP300

6.92e-053252HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

6.92e-053252HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

6.92e-053252HP:0005895
HumanPhenoAbnormality of mouth size

SOX11 GTF2I MTX2 HECW2 NEB CDC42BPB CREBBP EP300 LARP7

1.10e-04425259HP:0011337
HumanPhenoTrichiasis

CREBBP EP300

1.38e-044252HP:0001128
HumanPhenoVisceral hemangioma

CREBBP EP300

1.38e-044252HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

1.38e-044252HP:0011087
HumanPhenoWidened distal phalanges

CREBBP EP300

1.38e-044252HP:0006200
HumanPhenoVascular ring

CREBBP EP300

1.38e-044252HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

1.38e-044252HP:0031207
HumanPhenoLow hanging columella

SOX11 CDC42BPB CREBBP EP300

1.40e-0456254HP:0009765
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

2.29e-045252HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

2.29e-045252HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

2.29e-045252HP:0030421
HumanPhenoPhonophobia

GTF2I CREBBP EP300

2.52e-0426253HP:0002183
HumanPhenoLarge foramen magnum

CREBBP EP300

3.43e-046252HP:0002700
HumanPhenoSelf-injurious behavior

HECW2 NDN CDC42BPB CREBBP EP300 LARP7

4.19e-04210256HP:0100716
HumanPhenoDeviated nasal septum

CREBBP EP300

4.78e-047252HP:0004411
HumanPhenoAbnormal branching pattern of the aortic arch

CREBBP EP300 DNAH1

5.17e-0433253HP:0011587
HumanPhenoObstructive sleep apnea

NDN CDC42BPB CREBBP EP300

5.29e-0479254HP:0002870
HumanPhenoAbnormal cardiac septum morphology

ADK SOX11 GTF2I MTX2 MED23 CDC42BPB CREBBP EP300 LARP7 MYLK2 MYBPC3

6.19e-047872511HP:0001671
HumanPhenoAtrial septal defect

ADK SOX11 GTF2I MTX2 MED23 CDC42BPB CREBBP EP300 LARP7

6.88e-04541259HP:0001631
HumanPhenoAbnormality of the atrial septum

ADK SOX11 GTF2I MTX2 MED23 CDC42BPB CREBBP EP300 LARP7

6.88e-04541259HP:0001630
HumanPhenoAbnormal atrial septum morphology

ADK SOX11 GTF2I MTX2 MED23 CDC42BPB CREBBP EP300 LARP7

7.17e-04544259HP:0011994
HumanPhenoAuditory sensitivity

GTF2I CREBBP EP300

7.27e-0437253HP:0025112
HumanPhenoAuditory hypersensitivity

GTF2I CREBBP EP300

7.27e-0437253HP:5200060
HumanPhenoPilomatrixoma

CREBBP EP300

8.15e-049252HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

8.15e-049252HP:0002341
HumanPhenoPoor coordination

CDC42BPB CREBBP EP300

8.49e-0439253HP:0002370
DomainDUF4074

HOXA3 HOXB3 HOXD3

1.01e-073883IPR025281
DomainDUF4074

HOXA3 HOXB3 HOXD3

1.01e-073883PF13293
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

2.19e-052882IPR014744
DomainHAT_KAT11

CREBBP EP300

2.19e-052882PF08214
DomainKIX

CREBBP EP300

2.19e-052882PS50952
DomainZnF_TAZ

CREBBP EP300

2.19e-052882SM00551
DomainCBP_P300_HAT

CREBBP EP300

2.19e-052882IPR031162
DomainDUF902

CREBBP EP300

2.19e-052882PF06001
Domain-

CREBBP EP300

2.19e-0528821.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

2.19e-052882IPR010303
Domain-

CREBBP EP300

2.19e-0528821.10.1630.10
DomainCreb_binding

CREBBP EP300

2.19e-052882PF09030
Domain-

CREBBP EP300

2.19e-0528821.10.246.20
Domainzf-TAZ

CREBBP EP300

2.19e-052882PF02135
DomainZF_TAZ

CREBBP EP300

2.19e-052882PS50134
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

2.19e-052882IPR013178
DomainKAT11

CREBBP EP300

2.19e-052882SM01250
DomainZnf_TAZ

CREBBP EP300

2.19e-052882IPR000197
DomainKIX_dom

CREBBP EP300

2.19e-052882IPR003101
DomainKIX

CREBBP EP300

2.19e-052882PF02172
DomainCyclin_E

CCNE1 CCNE2

2.19e-052882IPR028858
DomainCBP_P300_HAT

CREBBP EP300

2.19e-052882PS51727
DomainCIR_N_dom

CIR1 CWC25

6.56e-053882IPR019339
DomainCir_N

CIR1 CWC25

6.56e-053882PF10197
DomainCir_N

CIR1 CWC25

6.56e-053882SM01083
DomainHomeobox_Antennapedia_CS

HOXA3 HOXB3 HOXD3

1.26e-0421883IPR001827
DomainANTENNAPEDIA

HOXA3 HOXB3 HOXD3

1.90e-0424883PS00032
DomainNuc_rcpt_coact

CREBBP EP300

3.25e-046882IPR009110
DomainCHCR

VPS39 VPS41

4.54e-047882PS50236
DomainClathrin_H-chain/VPS_repeat

VPS39 VPS41

6.03e-048882IPR000547
DomainC2_dom

PIK3C2B HECW2 SYDE2 C2CD6 SYT7

1.07e-03164885IPR000008
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH1

1.93e-0314882IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH1

1.93e-0314882IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH1

1.93e-0314882IPR013602
DomainDHC_N2

DNAH10 DNAH1

1.93e-0314882PF08393
DomainMT

DNAH10 DNAH1

1.93e-0314882PF12777
DomainAAA_8

DNAH10 DNAH1

1.93e-0314882PF12780
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH1

1.93e-0314882IPR011704
DomainCNH

VPS39 CDC42BPB

1.93e-0314882SM00036
DomainAAA_5

DNAH10 DNAH1

1.93e-0314882PF07728
DomainDHC_fam

DNAH10 DNAH1

2.21e-0315882IPR026983
DomainCNH

VPS39 CDC42BPB

2.21e-0315882PF00780
DomainDynein_heavy_dom

DNAH10 DNAH1

2.21e-0315882IPR004273
DomainCNH

VPS39 CDC42BPB

2.21e-0315882PS50219
DomainCNH_dom

VPS39 CDC42BPB

2.21e-0315882IPR001180
DomainDynein_heavy

DNAH10 DNAH1

2.21e-0315882PF03028
DomainCyclin_C

CCNE1 CCNE2

2.85e-0317882PF02984
DomainCyclin_C-dom

CCNE1 CCNE2

2.85e-0317882IPR004367
DomainCyclin_C

CCNE1 CCNE2

2.85e-0317882SM01332
DomainZZ

CREBBP EP300

3.20e-0318882PF00569
DomainZF_ZZ_2

CREBBP EP300

3.20e-0318882PS50135
DomainZF_ZZ_1

CREBBP EP300

3.20e-0318882PS01357
DomainZnf_ZZ

CREBBP EP300

3.56e-0319882IPR000433
DomainZnF_ZZ

CREBBP EP300

3.56e-0319882SM00291
DomainKinase-like_dom

CSNK1A1L EPHA6 RIPK1 PIK3C2B DAPK1 CDC42BPB PXK MYLK2

4.02e-03542888IPR011009
DomainHTH_motif

HOXA3 HOXB3 HOXD3

4.23e-0369883IPR000047
PathwayREACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES

CUL5 CREBBP EP300 IFNAR2

1.71e-0535634M48246
PathwayBIOCARTA_RELA_PATHWAY

RIPK1 CREBBP EP300

3.73e-0515633MM1339
PathwayBIOCARTA_RELA_PATHWAY

RIPK1 CREBBP EP300

3.73e-0515633M10183
PathwayREACTOME_RSV_HOST_INTERACTIONS

CUL5 MED23 CREBBP EP300 IFNAR2

7.48e-0598635M48247
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

RIPK1 NLRP4 CREBBP EP300

1.88e-0464634M27046
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

CUL5 MED23 CREBBP EP300 IFNAR2

1.95e-04120635M48233
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.95e-045632MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

1.95e-045632M48020
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

1.95e-045632M48023
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

1.95e-045632M27228
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

HOXA3 HOXB3 HOXD3 CREBBP EP300

2.10e-04122635M29689
PathwayWP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE

TRAF5 RIPK1 EP300 IFNAR2

2.12e-0466634M40067
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

2.91e-046632M22062
PathwayPID_E2F_PATHWAY

CCNE1 CCNE2 CREBBP EP300

3.13e-0473634M40
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

4.07e-047632MM1573
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E7_TO_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

4.07e-047632M47527
PathwayKEGG_MEDICUS_REFERENCE_TNF_RIPK1_3_SIGNALING_PATHWAY

TRAF5 RIPK1

4.07e-047632M47944
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

5.41e-048632M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

5.41e-048632M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

5.41e-048632M48024
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00498

CCNE1 CCNE2

5.41e-048632M47585
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_CDKN1B_TO_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

5.41e-048632M47429
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

5.41e-048632M46443
PathwayKEGG_PROSTATE_CANCER

CCNE1 CCNE2 CREBBP EP300

6.66e-0489634M13191
PathwayREACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS

CCNE1 CCNE2 KIF13A

6.93e-0439633M3871
PathwayBIOCARTA_FBW7_PATHWAY

CCNE1 CDC34

6.93e-049632MM1568
PathwayBIOCARTA_FBW7_PATHWAY

CCNE1 CDC34

6.93e-049632M22053
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00497

CCNE1 CCNE2

6.93e-049632M47584
PathwayKEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00482

CCNE1 CCNE2

6.93e-049632M47578
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

CCNE1 CCNE2

6.93e-049632MM15337
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

6.93e-049632M47451
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES

VPS39 VPS41

6.93e-049632M47777
PathwayPID_FOXM1_PATHWAY

CCNE1 CREBBP EP300

7.47e-0440633M176
PathwayPID_IFNG_PATHWAY

DAPK1 CREBBP EP300

7.47e-0440633M161
PathwayBIOCARTA_SKP2E2F_PATHWAY

CCNE1 CDC34

8.64e-0410632MM1384
PathwayKEGG_MEDICUS_REFERENCE_EXTRINSIC_APOPTOTIC_PATHWAY

TRAF5 RIPK1

8.64e-0410632M47447
PathwayBIOCARTA_SKP2E2F_PATHWAY

CCNE1 CDC34

8.64e-0410632M6031
PathwayKEGG_MEDICUS_REFERENCE_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES

VPS39 VPS41

8.64e-0410632M47776
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

8.64e-0410632M27945
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

1.05e-0311632MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

1.05e-0311632M48021
PathwayKEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00536

CCNE1 CCNE2

1.05e-0311632M47591
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

1.05e-0311632M26924
PathwayREACTOME_SARS_COV_2_MODULATES_AUTOPHAGY

VPS39 VPS41

1.05e-0311632M45018
PathwayKEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00264

CCNE1 CCNE2

1.05e-0311632M47492
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CIR1 CREBBP EP300

1.20e-0347633M7946
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

1.26e-0312632M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

1.26e-0312632M27765
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CCNE1 CCNE2 EP300

1.35e-0349633M27614
PathwaySA_REG_CASCADE_OF_CYCLIN_EXPR

CCNE1 CCNE2

1.49e-0313632M3686
PathwayPID_KIT_PATHWAY

PIK3C2B CREBBP VAV1

1.61e-0352633M231
PathwayKEGG_MEDICUS_PATHOGEN_HIV_NEF_TO_TNF_NFKB_SIGNALING_PATHWAY

TRAF5 RIPK1

1.73e-0314632M47567
PathwayKEGG_MEDICUS_REFERENCE_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

1.73e-0314632M47427
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

1.73e-0314632M27808
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

CCNE1 CCNE2

1.73e-0314632M27635
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_TNF_NFKB_SIGNALING_PATHWAY

TRAF5 RIPK1

1.99e-0315632M47566
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_MYC_TO_P27_CELL_CYCLE_G1_S

CCNE1 CCNE2

1.99e-0315632M47428
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.99e-0315632MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

1.99e-0315632M953
PathwayKEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY

TRAF5 RIPK1

2.27e-0316632M47569
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

2.27e-0316632M27121
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

2.27e-0316632M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

2.27e-0316632MM1420
PathwayWP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY

UQCC1 UQCC2

2.27e-0316632M39892
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

2.27e-0316632M8516
PathwayKEGG_MEDICUS_REFERENCE_TNF_NFKB_SIGNALING_PATHWAY

TRAF5 RIPK1

2.27e-0316632M47453
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR

VPS39 VPS41

2.27e-0316632M47978
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

2.27e-0316632M27940
PathwayKEGG_CELL_CYCLE

CCNE1 CCNE2 CREBBP EP300

2.34e-03125634M7963
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.56e-0317632MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

2.56e-0317632M48025
PathwayREACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS

CCNE1 CCNE2

2.56e-0317632M38998
PathwayWP_EBOLA_VIRUS_INFECTION_IN_HOST

VPS39 VPS41 CREBBP EP300

2.63e-03129634M39693
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

2.87e-0318632M26942
PathwayREACTOME_G0_AND_EARLY_G1

CCNE1 CCNE2

2.87e-0318632MM14594
PathwayPID_RB_1PATHWAY

CCNE1 CREBBP EP300

3.05e-0365633M279
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

3.20e-0319632M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

3.20e-0319632M46442
PathwayKEGG_PATHWAYS_IN_CANCER

CCNE1 TRAF5 CCNE2 DAPK1 CREBBP EP300

3.23e-03325636M12868
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

3.55e-0320632M27881
PathwayWP_UROTENSINIIMEDIATED_SIGNALING

CCNE1 CREBBP EP300

3.61e-0369633M48052
PathwayREACTOME_CIRCADIAN_CLOCK

NFIL3 CREBBP EP300

3.76e-0370633M938
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

3.91e-0321632M39593
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

RIPK1 NLRP4

3.91e-0321632M26978
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

3.91e-0321632M27485
PathwayBIOCARTA_G2_PATHWAY

CDC34 EP300

4.29e-0322632MM1365
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

4.29e-0322632MM1370
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

4.29e-0322632MM1443
Pubmed

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.

HOXA3 HOXB3 HOXD3

1.73e-0839137913519
Pubmed

Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.

CCNE1 CCNE2 CREBBP EP300

4.30e-081491411850820
Pubmed

Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures.

HOXA3 HOXB3 HOXD3

6.92e-0849139441667
Pubmed

The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.

HOXA3 HOXB3 HOXD3

6.92e-08491324127533
Pubmed

Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.

MED23 CREBBP EP300

1.73e-07591315572696
Pubmed

Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.

HOXA3 HOXB3 HOXD3

1.73e-0759139520319
Pubmed

Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor.

GTF2I CREBBP EP300

3.45e-07691317970752
Pubmed

The corepressor activity of Alien is controlled by CREB-binding protein/p300.

TAF1B CREBBP EP300

6.02e-07791323441852
Pubmed

Acetylation-dependent signal transduction for type I interferon receptor.

CREBBP EP300 IFNAR2

9.61e-07891317923090
Pubmed

Retinoic acid regulates a subset of Cdx1 function in vivo.

HOXA3 HOXB3 HOXD3

9.61e-07891314660544
Pubmed

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb.

CCNE1 CREBBP EP300

9.61e-07891314742445
Pubmed

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

CCNE1 CCNE2 CDC34

1.44e-06991311463388
Pubmed

Hox cofactors in vertebrate development.

HOXA3 HOXB3 HOXD3

2.05e-061091316515781
Pubmed

Rostral and caudal pharyngeal arches share a common neural crest ground pattern.

HOXA3 HOXB3 HOXD3

6.18e-061491319168678
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

6.77e-06291227881875
Pubmed

Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.

UQCC1 UQCC2

6.77e-06291224385928
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

6.77e-06291234845315
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

6.77e-06291219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

6.77e-06291215860545
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

6.77e-06291229460469
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

6.77e-06291224551300
Pubmed

Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients.

CCNE1 CCNE2

6.77e-06291216740753
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

6.77e-06291233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

6.77e-0629129018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

6.77e-06291224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

6.77e-06291230135524
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

6.77e-06291239287984
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

6.77e-06291216596650
Pubmed

Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms.

HOXA3 HOXB3

6.77e-06291211566863
Pubmed

Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.

MED23 LARP7

6.77e-06291223340209
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

6.77e-06291229217654
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

6.77e-06291220717166
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

6.77e-06291210049825
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

6.77e-06291227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

6.77e-06291229170789
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

6.77e-06291225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

6.77e-06291211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

6.77e-06291221555743
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

6.77e-06291212646247
Pubmed

Expression of cyclins E1 and E2 during mouse development and in neoplasia.

CCNE1 CCNE2

6.77e-06291211687642
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

6.77e-06291232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

6.77e-06291219822209
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

6.77e-06291224522976
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

6.77e-06291211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

6.77e-06291221847097
Pubmed

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

VPS39 VPS41

6.77e-06291223167963
Pubmed

Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.

CCNE1 CCNE2

6.77e-06291221109536
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

6.77e-06291211963968
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

6.77e-06291234813504
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

6.77e-0629129528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

6.77e-06291212696060
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

6.77e-06291220301699
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

6.77e-06291236109165
Pubmed

Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin.

CCNE1 CCNE2

6.77e-06291219445941
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

6.77e-06291224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

6.77e-06291237816914
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

6.77e-06291212242694
Pubmed

ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.

CUL5 ERP29

6.77e-06291230569094
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

6.77e-06291211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

6.77e-06291210918613
Pubmed

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

CREBBP EP300

6.77e-06291231182547
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

6.77e-06291235502657
Pubmed

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.

CREBBP EP300

6.77e-06291230635043
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

6.77e-06291231898871
Pubmed

Kinase-independent function of cyclin E.

CCNE1 CCNE2

6.77e-06291217218276
Pubmed

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.

CREBBP EP300

6.77e-06291227648933
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

6.77e-06291230888860
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

6.77e-06291227881443
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

6.77e-06291219272189
Pubmed

Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.

CREBBP EP300

6.77e-06291210610021
Pubmed

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.

CREBBP EP300

6.77e-06291237314181
Pubmed

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

CREBBP EP300

6.77e-06291212397173
Pubmed

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.

CREBBP EP300

6.77e-06291215641773
Pubmed

E-type cyclins modulate telomere integrity in mammalian male meiosis.

CCNE1 CCNE2

6.77e-06291226712234
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

6.77e-06291232690000
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.

CREBBP EP300

6.77e-0629129733868
Pubmed

CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.

CREBBP EP300

6.77e-06291230953353
Pubmed

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

CREBBP EP300

6.77e-06291221803292
Pubmed

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

CREBBP EP300

6.77e-0629129811832
Pubmed

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.

CREBBP EP300

6.77e-06291224089570
Pubmed

Sequence and expression of the murine Hoxd-3 homeobox gene.

HOXA3 HOXD3

6.77e-0629128710855
Pubmed

Rubinstein-Taybi syndrome in Chinese population with four novel mutations.

CREBBP EP300

6.77e-06291233063428
Pubmed

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.

CCNE1 CCNE2

6.77e-06291212970191
Pubmed

EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.

CREBBP EP300

6.77e-06291234506759
Pubmed

Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.

CREBBP EP300

6.77e-06291222177454
Pubmed

Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.

CCNE1 CCNE2

6.77e-06291223324395
Pubmed

Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.

CCNE1 CCNE2

6.77e-06291215611651
Pubmed

Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.

HOXA3 HOXD3

6.77e-0629127910549
Pubmed

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.

CREBBP EP300

6.77e-06291215706485
Pubmed

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

CREBBP EP300

6.77e-06291239266679
Pubmed

A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.

CREBBP EP300

6.77e-06291222303793
Pubmed

Maintenance of functional equivalence during paralogous Hox gene evolution.

HOXA3 HOXD3

6.77e-06291210688203
Pubmed

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

CREBBP EP300

6.77e-06291234732714
Pubmed

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

CREBBP EP300

6.77e-06291234019788
Pubmed

A distinct Hox code for the branchial region of the vertebrate head.

HOXA3 HOXB3 HOXD3

7.71e-06159131682814
Pubmed

Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.

HOXA3 HOXB3 HOXD3

1.15e-051791312954718
Pubmed

The HOX homeodomain proteins block CBP histone acetyltransferase activity.

HOXB3 CREBBP EP300

1.37e-051891311585930
Pubmed

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

MED23 CREBBP EP300

1.63e-051991316204234
Pubmed

Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.

CREBBP EP300

2.03e-05391214716005
Pubmed

The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.

CREBBP EP300

2.03e-05391218070920
InteractionHOXB3 interactions

HOXB3 CREBBP EP300

6.86e-069893int:HOXB3
Cytoband2p25

SOX11 TAF1B

5.70e-04189022p25
Cytoband2q31.1

MTX2 HOXD3 CIR1

6.19e-04849032q31.1
GeneFamilyHOXL subclass homeoboxes

HOXA3 HOXB3 HOXD3

7.18e-0452613518
GeneFamilyDyneins, axonemal

DNAH10 DNAH1

1.47e-0317612536
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

1.47e-0317612486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

1.65e-031861291
ToppCelldroplet-Bladder-nan-3m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA3 VPS41 MED23 ICA1L DNAH1

4.37e-06119905018162114bc22a9780fded5887f1f78211851700
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 HEATR9 EFHB DNAH1 ZBBX

1.58e-051559055f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 HEATR9 EFHB DNAH1 ZBBX

1.58e-051559050944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHA6 DNAH10 NEB C5orf47 L3MBTL4

1.95e-05162905bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MROH9 DNAH10 WDR17 DNAH1 ZBBX

2.39e-05169905fba841664939c771881ba97f14ef1df6635c04ff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 DNAH10 NEB RYR2 DNAH1

3.59e-051849052cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 DNAH10 NEB RYR2 DNAH1

3.59e-05184905ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 DNAH10 NEB RYR2 DNAH1

3.59e-051849052b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCF-Myeloid-cDC|CF / Disease state, Lineage and Cell class

TRAF5 GTF2I PLEKHA5 TBC1D17 L3MBTL4

3.69e-051859057f3d118845ff9f5f525796b0bbc6532a8ee323ab
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF5 PIK3C2B XKRX PXK DMXL1

3.98e-051889051f07e3ab87173426fe0c429f5c084fb3425effd3
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF5 PIK3C2B XKRX PXK DMXL1

3.98e-0518890585746f95319e494efdc1bbc24331698688d3a900
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HOXA3 SOX11 MTX2 HOXD3 NDN

4.19e-05190905b4dfc41f5a630140cab8b1b86de85de0f5b25e4a
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 PLEKHA5 EFHB ICA1L ZBBX

4.51e-05193905ea345d34440b25f65358a53dc72831998d1c3620
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH10 HEATR9 EFHB DNAH1 ZBBX

4.74e-0519590560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DNAH10 HEATR9 EFHB DNAH1 ZBBX

5.22e-0519990515f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH10 HEATR9 EFHB DNAH1 ZBBX

5.34e-0520090596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH10 HEATR9 EFHB DNAH1 ZBBX

5.34e-05200905da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

HOXB3 TRAF5 MICAL2 CKAP5 WDR17

5.34e-05200905a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH10 HEATR9 EFHB DNAH1 ZBBX

5.34e-0520090572c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
DiseaseMenke-Hennekam syndrome

CREBBP EP300

8.59e-062872cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

8.59e-062872DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

8.59e-062872cv:C0035934
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

8.59e-062872C4551859
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

8.59e-062872180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

8.59e-062872cv:C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

8.59e-062872DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

8.59e-062872C0035934
DiseaseMalignant neoplasm of breast

HOXA3 CUL5 CCNE1 TBC1D9B SFRP5 NF2 SBNO1 VPS39 HEATR9 UQCC1 PACC1 EP300

7.30e-0510748712C0006142
DiseaseAdenoid Cystic Carcinoma

SOX11 DAPK1 CREBBP EP300

2.23e-04100874C0010606
DiseaseCarcinoma, Transitional Cell

DAPK1 CREBBP EP300

2.43e-0441873C0007138
DiseaseCardiomyopathy, Hypertrophic, Familial

MYLK2 MYBPC3

3.05e-049872C0949658
DiseaseCognitive impairment

RYR2 DMXL1

4.65e-0411872HP_0100543
DiseaseSmall cell carcinoma of lung

LYRM9 CREBBP EP300

5.51e-0454873C0149925
DiseaseDiffuse Large B-Cell Lymphoma

TRAF5 CREBBP EP300

5.81e-0455873C0079744
DiseaseHypertrophic Cardiomyopathy

RYR2 MYLK2 MYBPC3

6.46e-0457873C0007194
Diseasediffuse idiopathic skeletal hyperostosis

NFIL3 UQCC1

8.80e-0415872EFO_0007236
Diseaseosteoarthritis, knee

SBNO1 UQCC1 ICA1L EP300

1.25e-03158874EFO_0004616
DiseaseLeukemia, Myelocytic, Acute

GTF2I DAPK1 CREBBP EP300

1.74e-03173874C0023467
DiseasePrimary familial hypertrophic cardiomyopathy

MYLK2 MYBPC3

1.91e-0322872cv:C0949658
Diseasepallidum volume

RPL13AP3 MYLK2

2.47e-0325872EFO_0006933
Diseaseazoospermia (implicated_via_orthology)

CDC34 CDC42BPB

2.88e-0327872DOID:14227 (implicated_via_orthology)
DiseaseAdenocarcinoma of large intestine

RIPK1 CDC42BPB EP300

2.90e-0396873C1319315

Protein segments in the cluster

PeptideGeneStartEntry
WKLVIMLKKNYEKFK

ERICH6B

391

Q5W0A0
KRLQEWYKKMLDKAV

EP300

1461

Q09472
WYKKMLDKAVSERIV

EP300

1466

Q09472
VNMEKFKKFAARKKW

DAPK1

291

P53355
WVQRYMKNLDAKQKK

CCL24

81

O00175
YKKEKHLDLEKNWML

ADK

161

P55263
EKLQEELKWRKIQYM

BTN3A3

306

O00478
ELKWRKIQYMARGEK

BTN3A3

311

O00478
KMIKEQIEWLIEHKY

CUL5

751

Q93034
GAVKKKEEKLDWMYQ

CWC25

61

Q9NXE8
KKWAEQYLKIMGKIL

ERP29

196

P30040
VWKIMLNKEKTYLRD

CCNE1

116

P24864
KEVWLNMLKKESRYV

CCNE2

111

O96020
PKRLQEWYKKMLDKA

CREBBP

1496

Q92793
MKKKAVIWGLYRAEK

DMXL1

1646

Q9Y485
NKKEYIERMVKWRIE

HECW2

1401

Q9P2P5
LQEWEEKKKCKMSYL

C20orf96

176

Q9NUD7
KIWFQNRRMKYKKDQ

HOXA3

236

O43365
WYQVKRMQDEKKKKS

HECA

191

Q9UBI9
MKGNQLWKYRKDKTL

GALNT10

541

Q86SR1
RLEKMKKEYRNLNTW

C2CD6

326

Q53TS8
SQILLKKYLMKRRWK

MYLK2

556

Q9H1R3
KKYLMKRRWKKNFIA

MYLK2

561

Q9H1R3
KYWKGLDEMKLRNLR

PDE8A

811

O60658
KKDAMYWEKRRKNNE

NFIL3

71

Q16649
LKKNVEEEYRKWKSM

MED23

756

Q9ULK4
KSEWMDLKKEYLALQ

LARP7

381

Q4G0J3
RKDKFVWMDYLKACK

L3MBTL4

156

Q8NA19
KKKMYWERKLQTFTK

MSANTD3

246

Q96H12
LMWYLEELKKEEFRK

NLRP4

11

Q96MN2
WQGLRAMTKKQKYEK

CSNK1A1L

221

Q8N752
WFQNRRMKYKKDQKA

HOXD3

241

P31249
KNTERIYAMKILNKW

CDC42BPB

96

Q9Y5S2
KDLYKLQILKEMLVW

MROH9

116

Q5TGP6
EKAKIHYWKKKQLMR

RPL13AP3

76

Q6NVV1
HYWKKKQLMRLRKQA

RPL13AP3

81

Q6NVV1
MVEVIYINRKKKVWD

IFNAR2

301

P48551
YTIKDTVAWLKMDKK

NF2

66

P35240
QRKLKDIMQKESLYW

PIK3C2B

816

O00750
LSIKWMIKIRKRYLK

PACC1

326

Q9H813
WAKKMKELEAAKKAY

PACSIN1

146

Q9BY11
YKKKLSMQQKQLDWR

HTATSF1

236

O43719
YANLMTRKEKDWVIK

PATL2

186

C9JE40
ERIWKKIMKNAYENR

DNAH1

1271

Q9P2D7
RMKDEKGLKVLKWNF

CKAP5

1171

Q14008
IMKKKKKVLVWNRVY

C5orf47

131

Q569G3
TLRKWLKMFKKRQLE

SERPINA5

286

P05154
QIKIWFQNRRMKYKK

HOXB3

231

P14651
KRAIEDADWIMNKYK

LYRM9

61

A8MSI8
LNWKDKMLLKEYEER

EFHB

626

Q8N7U6
KEEWYARITKLRKMV

GTF2I

456

P78347
VRRMQKKYWKTKQVF

ICA1L

16

Q8NDH6
LIMKGYKELNWKTAK

DNAH10

3171

Q8IVF4
KMYNKAVKLWVIARE

SBNO1

556

A3KN83
ENYHNIWAKKKKMEL

RYR2

2846

Q92736
WQKGAYLKDKMRKAV

TBRG4

611

Q969Z0
EWFKLVLEKNKLMRY

MICAL2

1851

O94851
QWYIKAKMKSEEKRR

EPHA6

576

Q9UF33
ILAYQKQWEVKRKMK

MTX2

156

O75431
KLIDMRDLYQEWKEK

KIF13A

751

Q9H1H9
VTVKKLQKWMYKGRL

SYDE2

186

Q5VT97
VKVWLMYKDKRVEKK

SYT7

306

O43581
KEYEGNMTWKIKLRR

TAS2R45

156

P59539
KRLGKRWKMLKDSEK

SOX11

81

P35716
LLLMAVYRWDKKNKE

SFRP5

276

Q5T4F7
VYRWDKKNKEMKFAV

SFRP5

281

Q5T4F7
RKWYQIMKKAFDEKK

TAF1B

401

Q53T94
SVKYWKKLMQRRADQ

WDR17

856

Q8IZU2
RDGLKEKVYQMLQKW

RIPK1

621

Q13546
LIWKVTDYKMKKREA

TRAF5

406

O00463
YLRMWAKEKEAQKET

TBC1D9B

1001

Q66K14
WRKRMLLTLKSNKYK

BRINP2

546

Q9C0B6
WMAEQKISYDKKKQE

CIR1

26

Q86X95
KPNKKYSWMRKKEER

TNRC18

1451

O15417
RKKTDEYFRMKLQWK

TBC1D17

341

Q9HA65
YRKKLLIQMKSIWKK

TRIM77

136

I1YAP6
VMYRKWKESKGKDRE

CDC34

146

P49427
RSKNKWKFYLKDGVM

GTF2A1L

446

Q9UNN4
WAVIAKMDRKKKLKE

SYCP1

956

Q15431
FKTRELKKKWMEQFE

VAV1

486

P15498
WLEYPDKTKELRKAM

HEATR9

21

A2RTY3
KEIDKGMWKKLQEKF

UQCC2

101

Q9BRT2
GWRIRKKYFLMKIKN

PXK

156

Q7Z7A4
LKYSKWKIKIAALRM

UQCC1

106

Q9NVA1
IDWLLEKKKYEEALM

VPS41

366

P49754
VFKRKLKMWLKRTQE

ZMYM6

1146

O95789
AWDLLQKEILEKMKY

USP31

486

Q70CQ4
RVQKLIKEMDYLWKI

TRIM64C

136

A6NLI5
LYKQDSTGMKLWKKR

PLEKHA5

176

Q9HAU0
AMIKYLTLWKKEEQE

XKRX

116

Q6PP77
KEDILSYMEKLWLKK

ZBBX

311

A8MT70
WDFDLKKLPNIKMRK

TMA16

146

Q96EY4
MCVAVKKKLQLYFWK

VPS39

136

Q96JC1
KKKKSYRWMRLNFDL

MYBPC3

811

Q14896
KLNMDKRLYTEKWNK

NEB

1741

P20929
KAHELMWYVLVKDQK

NDN

101

Q99608