Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	betaine-homocysteine S-methyltransferase activity	BHMT BHMT2	5.16e-05	2	144	2	GO:0047150
GeneOntologyMolecularFunction	arachidonate-CoA ligase activity	ACSL6 ACSL5 SLC27A3	5.81e-05	11	144	3	GO:0047676
GeneOntologyMolecularFunction	S-methyltransferase activity	BHMT MGMT BHMT2	5.81e-05	11	144	3	GO:0008172
GeneOntologyMolecularFunction	long-chain fatty acid-CoA ligase activity	ACSL6 ACSL5 SLC27A3	1.57e-04	15	144	3	GO:0004467
GeneOntologyMolecularFunction	laminin receptor activity	AGER BCAM	3.07e-04	4	144	2	GO:0005055
GeneOntologyMolecularFunction	beta-N-acetylhexosaminidase activity	HEXA HEXB	7.60e-04	6	144	2	GO:0004563
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSL6 ACSL5 SLC27A3	8.46e-04	26	144	3	GO:0015645
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	HEXA HEXB MAN2A1 CHI3L2 LCT	9.04e-04	103	144	5	GO:0004553
GeneOntologyMolecularFunction	CoA-ligase activity	ACSL6 ACSL5 SLC27A3	9.46e-04	27	144	3	GO:0016405
GeneOntologyMolecularFunction	thioredoxin-dependent peroxiredoxin activity	PRDX4 PRDX1	1.06e-03	7	144	2	GO:0140824
GeneOntologyMolecularFunction	thioredoxin peroxidase activity	PRDX4 PRDX1	1.06e-03	7	144	2	GO:0008379
GeneOntologyCellularComponent	beta-N-acetylhexosaminidase complex	HEXA HEXB	4.91e-05	2	147	2	GO:1905379
GeneOntologyCellularComponent	basement membrane	NPHS1 NID2 COL15A1 FREM1 HMCN2 HMCN1	2.26e-04	122	147	6	GO:0005604
Domain	G2F	NID2 HMCN2 HMCN1	1.68e-06	4	141	3	PF07474
Domain	NIDOGEN_G2	NID2 HMCN2 HMCN1	1.68e-06	4	141	3	PS50993
Domain	GFP	NID2 HMCN2 HMCN1	1.68e-06	4	141	3	IPR009017
Domain	G2_nidogen/fibulin_G2F	NID2 HMCN2 HMCN1	1.68e-06	4	141	3	IPR006605
Domain	Glycohydro_20b2	HEXA HEXB	5.66e-05	2	141	2	PF14845
Domain	-	HEXA HEXB	5.66e-05	2	141	2	3.30.379.10
Domain	Betaine-hCys_S-MeTrfase_BHMT	BHMT BHMT2	5.66e-05	2	141	2	IPR017226
Domain	Beta_hexosaminidase_sua/sub	HEXA HEXB	5.66e-05	2	141	2	IPR025705
Domain	HEX_eukaryotic_N	HEXA HEXB	5.66e-05	2	141	2	IPR029019
Domain	Chitobiase/Hex_dom_2-like	HEXA HEXB	5.66e-05	2	141	2	IPR029018
Domain	ASX_HYDROXYL	NID2 CUBN HMCN2 CELSR3 CELSR2 HMCN1	1.11e-04	100	141	6	PS00010
Domain	-	HEXA HEXB CHI3L2 LCT	1.36e-04	35	141	4	3.20.20.80
Domain	EGF-type_Asp/Asn_hydroxyl_site	NID2 CUBN HMCN2 CELSR3 CELSR2 HMCN1	1.53e-04	106	141	6	IPR000152
Domain	Ago_hook	TNRC6B TNRC6C	1.69e-04	3	141	2	PF10427
Domain	S-methyl_trans	BHMT BHMT2	1.69e-04	3	141	2	PF02574
Domain	HCY	BHMT BHMT2	1.69e-04	3	141	2	PS50970
Domain	Glyco_hydro_20_cat	HEXA HEXB	1.69e-04	3	141	2	IPR015883
Domain	Glyco_hydro_20	HEXA HEXB	1.69e-04	3	141	2	PF00728
Domain	G2F	NID2 HMCN1	1.69e-04	3	141	2	SM00682
Domain	HCY_dom	BHMT BHMT2	1.69e-04	3	141	2	IPR003726
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	1.69e-04	3	141	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	1.69e-04	3	141	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	1.69e-04	3	141	2	PF16608
Domain	-	BHMT BHMT2	1.69e-04	3	141	2	3.20.20.330
Domain	Glyco_hydro_catalytic_dom	HEXA HEXB CHI3L2 LCT	1.88e-04	38	141	4	IPR013781
Domain	Ig-like_fold	NPHS1 FNDC3B FLNB SDK2 COL20A1 CD1A HMCN2 HMCN1 AGER TREM2 BCAM HCFC2 IL2RB FCAMR EBF4	2.94e-04	706	141	15	IPR013783
Domain	EGF_CA	NID2 CUBN HMCN2 CELSR3 CELSR2 HMCN1	3.28e-04	122	141	6	SM00179
Domain	EGF-like_Ca-bd_dom	NID2 CUBN HMCN2 CELSR3 CELSR2 HMCN1	3.58e-04	124	141	6	IPR001881
Domain	EGF	NID2 ZAN CUBN CELSR3 CELSR2 HMCN1	3.90e-04	126	141	6	PF00008
Domain	-	NPHS1 FNDC3B FLNB SDK2 COL20A1 CD1A HMCN1 AGER TREM2 BCAM HCFC2 IL2RB FCAMR EBF4	5.00e-04	663	141	14	2.60.40.10
Domain	1-cysPrx_C	PRDX4 PRDX1	5.58e-04	5	141	2	PF10417
Domain	-	LMNB2 LMNA	5.58e-04	5	141	2	2.60.40.1260
Domain	Lamin_tail_dom	LMNB2 LMNA	5.58e-04	5	141	2	IPR001322
Domain	LTD	LMNB2 LMNA	5.58e-04	5	141	2	PF00932
Domain	Peroxiredoxin_C	PRDX4 PRDX1	5.58e-04	5	141	2	IPR019479
Domain	Glycoside_hydrolase_SF	HEXA HEXB CHI3L2 LCT	6.84e-04	53	141	4	IPR017853
Domain	GOLGA6L	GOLGA6L4 GOLGA6L19	8.32e-04	6	141	2	IPR026737
Domain	EGF_2	NID2 ZAN CUBN HMCN2 CELSR3 CELSR2 HMCN1 NTN5	9.22e-04	265	141	8	PS01186
Domain	Laminin_G	COL15A1 COL20A1 CELSR3 CELSR2	9.63e-04	58	141	4	IPR001791
Domain	AMP-binding_CS	ACSL6 ACSL5 SLC27A3	9.64e-04	26	141	3	IPR020845
Domain	AhpC/TSA	PRDX4 PRDX1	1.16e-03	7	141	2	IPR000866
Domain	AhpC-TSA	PRDX4 PRDX1	1.16e-03	7	141	2	PF00578
Domain	Growth_fac_rcpt_	NID2 ERBB3 CUBN HMCN2 CELSR2 HMCN1	1.20e-03	156	141	6	IPR009030
Domain	AMP_BINDING	ACSL6 ACSL5 SLC27A3	1.20e-03	28	141	3	PS00455
Domain	AMP-binding	ACSL6 ACSL5 SLC27A3	1.47e-03	30	141	3	PF00501
Domain	AMP-dep_Synth/Lig	ACSL6 ACSL5 SLC27A3	1.47e-03	30	141	3	IPR000873
Domain	EGF_LAM_2	CELSR3 CELSR2 NTN5	1.47e-03	30	141	3	PS50027
Domain	EGF_LAM_1	CELSR3 CELSR2 NTN5	1.47e-03	30	141	3	PS01248
Domain	EGF_3	NID2 ZAN CUBN HMCN2 CELSR3 CELSR2 HMCN1	2.07e-03	235	141	7	PS50026
Domain	EGF_Lam	CELSR3 CELSR2 NTN5	2.31e-03	35	141	3	SM00180
Domain	Laminin_EGF	CELSR3 CELSR2 NTN5	2.31e-03	35	141	3	PF00053
Domain	Sugar_P_trans_dom	SLC35E2B SLC35E2A	2.45e-03	10	141	2	IPR004853
Domain	TPT	SLC35E2B SLC35E2A	2.45e-03	10	141	2	PF03151
Domain	FN3	NPHS1 FNDC3B SDK2 COL20A1 HCFC2 IL2RB	2.83e-03	185	141	6	SM00060
Domain	EGF-like_dom	NID2 ZAN CUBN HMCN2 CELSR3 CELSR2 HMCN1	2.87e-03	249	141	7	IPR000742
Domain	Laminin_EGF	CELSR3 CELSR2 NTN5	2.93e-03	38	141	3	IPR002049
Domain	GFP-like	NID2 HMCN1	2.98e-03	11	141	2	IPR023413
Domain	-	NID2 HMCN1	2.98e-03	11	141	2	2.40.155.10
Domain	GAIN_dom_N	CELSR3 CELSR2	2.98e-03	11	141	2	IPR032471
Domain	GAIN	CELSR3 CELSR2	2.98e-03	11	141	2	PF16489
Domain	EGF_1	ZAN CUBN HMCN2 CELSR3 CELSR2 HMCN1 NTN5	3.27e-03	255	141	7	PS00022
Domain	VWFA	INTS6L COL20A1 HMCN2 HMCN1	3.45e-03	82	141	4	PS50234
Domain	EGF_dom	NID2 CUBN	3.55e-03	12	141	2	IPR024731
Domain	C8	ZAN MUC2	3.55e-03	12	141	2	PF08742
Domain	EGF_3	NID2 CUBN	3.55e-03	12	141	2	PF12947
Domain	TIL	ZAN MUC2	3.55e-03	12	141	2	PF01826
Domain	C2-set_2	NPHS1 AGER BCAM	3.64e-03	41	141	3	PF08205
Domain	CD80_C2-set	NPHS1 AGER BCAM	3.64e-03	41	141	3	IPR013162
Domain	EGF-like_CS	NID2 ZAN CUBN HMCN2 CELSR3 CELSR2 HMCN1	3.71e-03	261	141	7	IPR013032
Domain	VWA	INTS6L COL20A1 HMCN2 HMCN1	3.77e-03	84	141	4	SM00327
Domain	FN3	NPHS1 FNDC3B SDK2 COL20A1 HCFC2 IL2RB	4.05e-03	199	141	6	PS50853
Domain	EGF_CA	NID2 CUBN HMCN2 HMCN1	4.10e-03	86	141	4	PF07645
Domain	Unchr_dom_Cys-rich	ZAN MUC2	4.18e-03	13	141	2	IPR014853
Domain	C8	ZAN MUC2	4.18e-03	13	141	2	SM00832
Domain	LamG	COL15A1 CELSR3 CELSR2	4.45e-03	44	141	3	SM00282
Domain	TIL_dom	ZAN MUC2	4.85e-03	14	141	2	IPR002919
Domain	FN3_dom	NPHS1 FNDC3B SDK2 COL20A1 HCFC2 IL2RB	5.13e-03	209	141	6	IPR003961
Domain	EGF_Ca-bd_CS	NID2 CUBN HMCN2 HMCN1	6.27e-03	97	141	4	IPR018097
Domain	VWF_type-D	ZAN MUC2	6.34e-03	16	141	2	IPR001846
Domain	VWFD	ZAN MUC2	6.34e-03	16	141	2	PS51233
Domain	VWD	ZAN MUC2	6.34e-03	16	141	2	SM00216
Domain	VWD	ZAN MUC2	6.34e-03	16	141	2	PF00094
Domain	EGF_CA	NID2 CUBN HMCN2 HMCN1	6.74e-03	99	141	4	PS01187
Domain	VWF_A	INTS6L COL20A1 HMCN2 HMCN1	6.74e-03	99	141	4	IPR002035
Domain	Quinoprotein_ADH-like_supfam	FAM234A ERN2 EML5	7.49e-03	53	141	3	IPR011047
Pathway	KEGG_MEDICUS_REFERENCE_KERATAN_SULFATE_DEGRADATION	HEXA HEXB GNS	3.75e-06	5	103	3	M47609
Pathway	BIOCARTA_IL2RB_PATHWAY	FOS PTPN6 SYK IL2RB	1.32e-04	36	103	4	MM1418
Pathway	BIOCARTA_IL2RB_PATHWAY	FOS PTPN6 SYK IL2RB	1.47e-04	37	103	4	M8615
Pathway	REACTOME_KERATAN_SULFATE_DEGRADATION	HEXA HEXB GNS	1.62e-04	15	103	3	M691
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES	HEXA HEXB SLC33A1	1.62e-04	15	103	3	M8535
Pathway	REACTOME_KERATAN_SULFATE_DEGRADATION	HEXA HEXB GNS	1.62e-04	15	103	3	MM14799
Pathway	WP_GLYCOSAMINOGLYCAN_DEGRADATION	HEXA HEXB GNS	2.39e-04	17	103	3	M39832
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	6.00e-17	12	154	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.55e-16	13	154	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.32e-16	8	154	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.45e-15	10	154	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.88e-14	13	154	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	5.45e-13	17	154	7	11245978
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPN3 HEXA ITPRIPL2 UBR4 EMID1 APBB3 PEX6 LMNB2 TNRC6C SLC35E2B HIVEP3 INTS5 ARAP3 CELSR3 CELSR2 ZNF341 TMEM132A KIFC3 BCAM PRRT4 IQCE	2.14e-08	1105	154	21	35748872
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	3.39e-07	4	154	3	17911620
Pubmed	Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.	NID2 HMCN2 HMCN1	3.39e-07	4	154	3	36007682
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	3.39e-07	4	154	3	38509386
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	EPN3 NPHS1 FLNB SLC5A10 COL15A1 MAN2A1 DSG3 JADE2 CUBN SHROOM2 PHGDH RUSC2 PTPN6 EML5 BHMT2 KIFC3 BCAM SLC39A5	6.53e-07	1016	154	18	19056867
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	8.46e-07	5	154	3	20063414
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	2.94e-06	7	154	3	30765463
Pubmed	TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.	AGER TREM2 SYK	2.94e-06	7	154	3	29518356
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HEXA HEXB FNDC3B NID2 FLNB ERBB3 MAN2A1 TOR2A PRDX4 ITPR1 SCCPDH LMNA CELSR2 AJM1 PRDX1 MAP3K10 KIFC3 SF3B2 ACSL5 SLC27A3	6.95e-06	1451	154	20	30550785
Pubmed	The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.	FLNB PRDX4 TNRC6B	9.99e-06	10	154	3	36357400
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	UBR4 DUX4 HSPA12B SHROOM2 SF3B1 PPP1R3F TET3 IQCE	1.01e-05	233	154	8	37704626
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB SDK2 ACACB MYO7B RFC1 SF3B1 CCAR1 SF3B2	1.05e-05	234	154	8	36243803
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	HEXA FLNB SHROOM2 CELSR3 CELSR2 AGER SMARCD2 SLC24A1 GNS	1.73e-05	329	154	9	17474147
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	SOX10 ERBB3 JARID2 IGF1 EFNA4 CELSR3 CELSR2 EBF4	1.73e-05	251	154	8	29031500
Pubmed	Defining the membrane proteome of NK cells.	HEXA HEXB MAN2A1 UBR4 PDCD2L CCDC88B APOBR ITPR1 NBAS INTS5 SCCPDH MGMT IL2RB SLC33A1 ACSL5 SLC27A3 PSD4	1.80e-05	1168	154	17	19946888
Pubmed	Activity of lysosomal exoglycosidases in human gliomas.	HEXA HEXB	1.95e-05	2	154	2	16710745
Pubmed	Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.	HEXA HEXB	1.95e-05	2	154	2	3013851
Pubmed	Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.	SERHL2 SERHL	1.95e-05	2	154	2	11352564
Pubmed	Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.	HEXA HEXB	1.95e-05	2	154	2	6458607
Pubmed	Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	1.95e-05	2	154	2	8789434
Pubmed	Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells.	LMNB2 LMNA	1.95e-05	2	154	2	2544227
Pubmed	Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins.	PRDX4 PRDX1	1.95e-05	2	154	2	20610706
Pubmed	Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.	HEXA HEXB	1.95e-05	2	154	2	2965147
Pubmed	The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis.	HEXA HEXB	1.95e-05	2	154	2	1825792
Pubmed	Plasma and peripheral leukocyte beta-N-acetylhexosaminidase isoenzymes and disease activity in rheumatoid arthritis.	HEXA HEXB	1.95e-05	2	154	2	12413610
Pubmed	A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.	HEXA HEXB	1.95e-05	2	154	2	9694901
Pubmed	Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.	CELSR3 CELSR2	1.95e-05	2	154	2	10790539
Pubmed	GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.	HEXA HEXB	1.95e-05	2	154	2	22789865
Pubmed	Biochemical consequences of mutations causing the GM2 gangliosidoses.	HEXA HEXB	1.95e-05	2	154	2	10571007
Pubmed	Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.	HEXA HEXB	1.95e-05	2	154	2	7550345
Pubmed	Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation.	PRDX4 PRDX1	1.95e-05	2	154	2	23737084
Pubmed	Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology.	HEXA HEXB	1.95e-05	2	154	2	19166507
Pubmed	YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner.	YTHDC1 PTPN6	1.95e-05	2	154	2	38289832
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	1.95e-05	2	154	2	24145033
Pubmed	Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay-Sachs Disease and Sandhoff Disease Mouse Models.	HEXA HEXB	1.95e-05	2	154	2	34201771
Pubmed	Novel bicistronic lentiviral vectors correct β-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis.	HEXA HEXB	1.95e-05	2	154	2	31682993
Pubmed	Three novel mutations in Iranian patients with Tay-Sachs disease.	HEXA HEXB	1.95e-05	2	154	2	24518553
Pubmed	Expression pattern of RAGE and IGF-1 in the human fetal ovary and ovarian serous carcinoma.	IGF1 AGER	1.95e-05	2	154	2	25724694
Pubmed	Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells.	HEXA HEXB	1.95e-05	2	154	2	21637923
Pubmed	Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	1.95e-05	2	154	2	9302266
Pubmed	Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma.	PRDX1 FOXO4	1.95e-05	2	154	2	34055579
Pubmed	A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C.	FOS LMNA	1.95e-05	2	154	2	16452503
Pubmed	Knock-down of HEXA and HEXB genes correlate with the absence of the immunostimulatory function of HSC-derived dendritic cells.	HEXA HEXB	1.95e-05	2	154	2	21997228
Pubmed	Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.	HEXA HEXB	1.95e-05	2	154	2	8896570
Pubmed	Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.	BHMT BHMT2	1.95e-05	2	154	2	18457970
Pubmed	Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.	HEXA HEXB	1.95e-05	2	154	2	6230359
Pubmed	Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.	PRDX4 PRDX1	1.95e-05	2	154	2	9388242
Pubmed	Negative feedback by IRE1β optimizes mucin production in goblet cells.	ERN2 MUC2	1.95e-05	2	154	2	23386727
Pubmed	Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.	HEXA HEXB	1.95e-05	2	154	2	8123671
Pubmed	Genetic expression of hexokinase and glucose phosphate isomerase in late-stage mouse preimplantation embryos: transcription activities in glucose/phosphate-containing HTF and glucose/phosphate-free P1 media.	HEXA HEXB	1.95e-05	2	154	2	9237263
Pubmed	Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma.	SOX10 ERBB3	1.95e-05	2	154	2	16896310
Pubmed	SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.	SLC35E2B SLC35E2A	1.95e-05	2	154	2	35247439
Pubmed	Laminopathies and lamin-associated signaling pathways.	LMNB2 LMNA	1.95e-05	2	154	2	21400569
Pubmed	Different expression of beta-N-acetylhexosaminidase in mouse tissues.	HEXA HEXB	1.95e-05	2	154	2	8147878
Pubmed	Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.	BHMT BHMT2	1.95e-05	2	154	2	18230605
Pubmed	Identification of domains in human beta-hexosaminidase that determine substrate specificity.	HEXA HEXB	1.95e-05	2	154	2	8663217
Pubmed	Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues.	HMCN2 HMCN1	1.95e-05	2	154	2	32035013
Pubmed	Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix.	LMNB2 LMNA	1.95e-05	2	154	2	2406262
Pubmed	Pediatric reference data on activity of urinary N-acetyl-β-D-hexosaminidase and its isoenzymes.	HEXA HEXB	1.95e-05	2	154	2	28846871
Pubmed	I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.	HEXA HEXB	1.95e-05	2	154	2	10591618
Pubmed	Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.	HEXA HEXB	1.95e-05	2	154	2	9417048
Pubmed	The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.	PTPN6 SYK	1.95e-05	2	154	2	24899508
Pubmed	Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor.	AGER FOXO4	1.95e-05	2	154	2	17667983
Pubmed	Physiological substrates for human lysosomal beta -hexosaminidase S.	HEXA HEXB	1.95e-05	2	154	2	11707436
Pubmed	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.	HEXA HEXB	1.95e-05	2	154	2	8634145
Pubmed	Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.	HEXA HEXB	1.95e-05	2	154	2	8672428
Pubmed	[Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].	HEXA HEXB	1.95e-05	2	154	2	23370522
Pubmed	Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.	PTPN6 SYK	1.95e-05	2	154	2	10072516
Pubmed	Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.	HEXA HEXB	1.95e-05	2	154	2	8673609
Pubmed	Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.	HEXA HEXB	1.95e-05	2	154	2	15953731
Pubmed	Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.	HEXA HEXB	1.95e-05	2	154	2	2971395
Pubmed	Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology.	HEXA HEXB	1.95e-05	2	154	2	9184660
Pubmed	Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.	HEXA HEXB	1.95e-05	2	154	2	16698036
Pubmed	Accumulated α-synuclein affects the progression of GM2 gangliosidoses.	HEXA HEXB	1.95e-05	2	154	2	27453479
Pubmed	Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence.	LMNB2 LMNA	1.95e-05	2	154	2	2719959
Pubmed	Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway.	SYK IL2RB	1.95e-05	2	154	2	7600304
Pubmed	Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.	BHMT BHMT2	1.95e-05	2	154	2	26213999
Pubmed	Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.	BHMT BHMT2	1.95e-05	2	154	2	11087663
Pubmed	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.	HEXA HEXB	1.95e-05	2	154	2	7959736
Pubmed	Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.	BHMT BHMT2	1.95e-05	2	154	2	12818402
Pubmed	Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.	PHGDH BHMT BHMT2	2.99e-05	14	154	3	23378610
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ERBB3 SDK2 UBR4 YTHDC1 CCDC88B SF3B1 HMCN2 CELSR3 LMNA	3.58e-05	361	154	9	26167880
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	3.73e-05	15	154	3	35727972
Pubmed	A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.	TOR2A LMNB2 LMNA	3.73e-05	15	154	3	20457914
Pubmed	Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.	FOS IGF1 TREM2	3.73e-05	15	154	3	30606613
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	3.73e-05	15	154	3	30071041
Pubmed	Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.	HMCN2 HMCN1	5.83e-05	3	154	2	12388743
Pubmed	An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin.	LMNB2 LMNA	5.83e-05	3	154	2	25312645
Pubmed	Glycosphingolipid degradation and animal models of GM2-gangliosidoses.	HEXA HEXB	5.83e-05	3	154	2	9728335
Pubmed	Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.	BHMT BHMT2	5.83e-05	3	154	2	25846410
Pubmed	A- and B-type lamins are differentially expressed in normal human tissues.	LMNB2 LMNA	5.83e-05	3	154	2	9243284
Pubmed	Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.	BHMT BHMT2	5.83e-05	3	154	2	29356306
Pubmed	Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.	TREM2 SYK	5.83e-05	3	154	2	18957693
Pubmed	Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes.	HEXA HEXB	5.83e-05	3	154	2	1054503
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.47e-10	27	153	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	6.35e-09	117	153	8	chr4q35
Cytoband	16p11	APOBR IL27	2.29e-04	7	153	2	16p11
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	ACSL6 JADE2 APBB3 BRD8 ARAP3 AFF4	5.17e-04	298	153	6	chr5q31
Cytoband	5q31	ACSL6 APBB3 BRD8 AFF4	6.15e-04	115	153	4	5q31
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	7.13e-07	92	99	7	521
GeneFamily	Lamins	LMNB2 LMNA	8.87e-05	3	99	2	612
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR3 CELSR2	8.87e-05	3	99	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR3 CELSR2	8.87e-05	3	99	2	1189
GeneFamily	Acyl-CoA synthetase family	ACSL6 ACSL5 SLC27A3	3.78e-04	26	99	3	40
GeneFamily	Peroxiredoxins	PRDX4 PRDX1	4.39e-04	6	99	2	953
GeneFamily	Fibulins	HMCN2 HMCN1	8.13e-04	8	99	2	556
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	NPHS1 AGER BCAM	1.36e-03	40	99	3	592
GeneFamily	Solute carriers	SLC5A10 SLC35E2B SLC6A6 SLC35E2A SLC24A1 SLC39A5 SLC33A1 SLC27A3	1.47e-03	395	99	8	752
GeneFamily	Integrator complex	INTS6L INTS5	2.98e-03	15	99	2	1366
GeneFamily	Immunoglobulin like domain containing	NPHS1 SDK2 HMCN2 AGER BCAM	4.19e-03	193	99	5	594
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_1H_UP	TICRR ERBB3 SDK2 EVC2 FOS EMID1 SP8 SLC39A5	1.05e-05	182	150	8	M4255
Coexpression	FLETCHER_PBMC_BCG_10W_INFANT_BCG_STIMULATED_VS_UNSTIMULATED_10W_DN	HEXB FOS PTPN6 ARAP3 PTPRE LMNA LTBR KIFC3 SLC27A3	1.76e-05	256	150	9	M41152
Coexpression	GSE27786_LSK_VS_CD8_TCELL_UP	INTS6L HEXA TICRR ITPRIPL2 PRDX4 HSPA12B PTPRE LTBR	2.01e-05	199	150	8	M4749
Coexpression	GSE8621_UNSTIM_VS_LPS_PRIMED_UNSTIM_MACROPHAGE_DN	MAN2A1 MLX TOR2A JADE2 APOBR NBAS ZNF341 HCFC2	2.08e-05	200	150	8	M6980
Coexpression	KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN	HEXA FNDC3B FLNB MAN2A1 TNRC6B ORAI2 CREB3L1 LMNA HMCN1 GNS	2.58e-05	337	150	10	M13206
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FNDC3B FLNB UBR4 APOBR ITPR1 JARID2 PTPN6 PTPRE SYK TNS1	1.37e-09	199	148	10	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	EPN3 MAN2A1 DSG3 JADE2 SLC6A6 CD1A EML5 PTPRE	7.65e-08	163	148	8	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	facs-Spleen-nan-24m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PI16 OLFML2B TRPM2 APOBR ARAP3 PNPLA1 MAPK4	9.34e-07	156	148	7	034d4359359a44c205c6931f38a375271ac2752b
ToppCell	facs-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PI16 OLFML2B TRPM2 APOBR ARAP3 PNPLA1 MAPK4	9.34e-07	156	148	7	21267718d3a3dc19988663b6846aed8bb3eae836
ToppCell	facs-Spleen-nan-24m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PI16 OLFML2B TRPM2 APOBR ARAP3 PNPLA1 MAPK4	9.34e-07	156	148	7	2a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NID2 RNF112 FREM1 IGF1 ARAP3 BHMT2 SLC24A1	1.79e-06	172	148	7	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL15A1 PI16 OLFML2B CREB3L1 PHGDH IGF1 HMCN2	2.43e-06	180	148	7	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL15A1 PI16 OLFML2B CREB3L1 PHGDH IGF1 HMCN2	2.61e-06	182	148	7	e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ITPRIPL2 SLC6A6 ARAP3 BCAM TNS1 PRRT4	2.61e-06	182	148	7	ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ITPRIPL2 SLC6A6 ARAP3 BCAM TNS1 PRRT4	2.61e-06	182	148	7	b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ITPRIPL2 SLC6A6 ARAP3 BCAM TNS1 PRRT4	2.61e-06	182	148	7	e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 COL15A1 COL20A1 OLFML2B CREB3L1 FREM1 HMCN1	2.91e-06	185	148	7	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 COL15A1 COL20A1 OLFML2B CREB3L1 FREM1 HMCN1	2.91e-06	185	148	7	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOS EMID1 NCKAP5L SLC6A6 PTPRE BCAM TNS1	3.59e-06	191	148	7	2f733d510a4862565a817f59829d8387d7ea26d9
ToppCell	390C-Lymphocytic-NK_cells\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HEXA APOBR PTPN6 PTPRE SYK IL2RB SLC27A3	4.55e-06	198	148	7	623e5ada1a54cd42c32a1519b84dbe782384ee0c
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPN3 NID2 FOXA2 AGER KIFC3 BCAM FCAMR	4.70e-06	199	148	7	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	BAL-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	HEXA HEXB FNDC3B PRDX1 TREM2 GNS SLC27A3	4.70e-06	199	148	7	4518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCell	tumor_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	HEXA HEXB OLFML2B FOS PRDX1 TREM2 GNS	4.86e-06	200	148	7	58ff8db0ecf71daa86f9a38208e0d9b712cac0b5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuroepithelial\|6m / Sample Type, Dataset, Time_group, and Cell type.	NID2 COL15A1 ITPRIPL2 FOS CREB3L1 IGF1 LMNA	4.86e-06	200	148	7	2cc98abf11f5b58707de45a2282f03d47f00f035
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuroepithelial-Proteoglycan-expressing_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	NID2 COL15A1 ITPRIPL2 FOS CREB3L1 IGF1 LMNA	4.86e-06	200	148	7	0f7431f670f3a175377cefae3479403a881bb8fb
ToppCell	Severe-Myeloid-Macrophages-FCN1-SPP1+\|Severe / Condition, Lineage, Cell class and cell subclass	HEXA HEXB OLFML2B LMNA PRDX1 TREM2 GNS	4.86e-06	200	148	7	b8cd209b810312793465b28bb2a6cbe5d94da91f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL15A1 CREB3L1 FREM1 SP8 IGF1 TNS1	4.88e-06	130	148	6	56b9c3325e011f1dbaf9efc71bd6e1af4f96fda6
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CREB3L1 PHGDH FREM1 SP8 AHRR IGF1	1.07e-05	149	148	6	5293c50b3fb41b1edaf9a97354899bd13770078c
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 PI16 FOS CCDC88B PNMA5 ARAP3	1.15e-05	151	148	6	ced4f7ee377a23a804ae6fde624e8b55b79f1fd8
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 PI16 FOS CCDC88B PNMA5 ARAP3	1.15e-05	151	148	6	b52bb3b88e9a6473f571053537b8beb418678539
ToppCell	367C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NPHS1 OLFML2B FOS ARAP3 HMCN1 IL27	1.44e-05	157	148	6	f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1orf167 SHROOM2 FREM1 PNMA5 AHRR MAP3K10	1.84e-05	164	148	6	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	droplet-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM234A FOS APOBR HMCN1 TREM2 LTBR	1.97e-05	166	148	6	f751cbd01d4978ded7755874ab60504f6291afd7
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL6 NID2 EMID1 BHMT AGER FOXO4	2.18e-05	169	148	6	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL6 NID2 EMID1 BHMT AGER FOXO4	2.18e-05	169	148	6	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL6 NID2 EMID1 BHMT AGER FOXO4	2.18e-05	169	148	6	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	APOBR PTPN6 PTPRE SYK IL2RB SLC27A3	2.25e-05	170	148	6	81341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPN3 DSG3 APOBR AJM1 SLC39A5 FCAMR	2.49e-05	173	148	6	81c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 ACACB ORAI2 PHGDH IGF1 SLC39A5	2.57e-05	174	148	6	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 ACACB ORAI2 PHGDH IGF1 SLC39A5	2.57e-05	174	148	6	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 ACACB ORAI2 IGF1 TNS1 SLC39A5	2.65e-05	175	148	6	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIPL2 OLFML2B FOS CCDC88B PTPRE SYK	2.65e-05	175	148	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXA HEXB FOS IGF1 PTPRE TREM2	2.74e-05	176	148	6	adb679e69c0c17f0caee4c141bac55d03c963012
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXA HEXB FOS IGF1 PTPRE TREM2	2.83e-05	177	148	6	ab92ffc9624850a50c88e6b8f3a517ff2251ff15
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOS FOXA2 LMNA BCAM TNS1 EBF4	2.83e-05	177	148	6	8c6d8a1c469346e66f9095d86b4615f8fc611362
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MYO7B FOS HIVEP3 CD1A PTPN6 FAM53B	2.92e-05	178	148	6	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN PNPLA1 BHMT2 SLC39A5	3.01e-05	179	148	6	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 COL15A1 PI16 OLFML2B CREB3L1 IGF1	3.11e-05	180	148	6	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.30e-05	182	148	6	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.30e-05	182	148	6	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.30e-05	182	148	6	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PI16 OLFML2B EMID1 HSPA12B ARAP3	3.30e-05	182	148	6	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC5A10 MYO7B CUBN BHMT BHMT2 HYDIN	3.41e-05	183	148	6	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOS FOXA2 HMCN1 BCAM TNS1 EBF4	3.41e-05	183	148	6	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 BHMT2	3.51e-05	184	148	6	9434731f651820b05335085582960f08fbf895de
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 COL15A1 OLFML2B MSLNL HYDIN SLC27A3	3.51e-05	184	148	6	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.73e-05	186	148	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.84e-05	187	148	6	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FNDC3B FLNB ERBB3 MAN2A1 ACACB MGMT	3.84e-05	187	148	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	droplet-Marrow-nan-21m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB PI16 OLFML2B FOS PTPN6	3.84e-05	187	148	6	20b25b0d08550a1e8e997c5ce67d8e34bf7fc398
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT PNPLA1 SLC39A5	3.84e-05	187	148	6	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NID2 COL15A1 PI16 FREM1 IGF1 HMCN2	3.96e-05	188	148	6	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	COL15A1 OLFML2B NCKAP5L RUSC2 SLC6A6 JARID2	3.96e-05	188	148	6	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PI16 OLFML2B IGF1 HMCN2 LMNA HMCN1	3.96e-05	188	148	6	409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITPRIPL2 PHGDH SLC6A6 LMNA TNS1 GNS	4.08e-05	189	148	6	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT BHMT2 KIFC3	4.08e-05	189	148	6	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	FLNB SHROOM2 ITPR1 ARAP3 HMCN1 TMEM108	4.08e-05	189	148	6	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIPL2 PHGDH SLC6A6 LMNA TNS1 GNS	4.08e-05	189	148	6	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	droplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIPL2 PHGDH SLC6A6 LMNA TNS1 GNS	4.08e-05	189	148	6	6d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT BHMT2 KIFC3	4.08e-05	189	148	6	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITPRIPL2 PHGDH SLC6A6 LMNA TNS1 GNS	4.20e-05	190	148	6	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	droplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHGDH SLC6A6 PTPRE LMNA BCAM TNS1	4.20e-05	190	148	6	c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCell	facs-Thymus-Epithelium-24m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B FOS FOXA2 LMNA BCAM SLC27A3	4.32e-05	191	148	6	eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B FOS FOXA2 LMNA BCAM SLC27A3	4.32e-05	191	148	6	1730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT BHMT2 KIFC3	4.32e-05	191	148	6	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	E15.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXA2 PHGDH AGER PRDX1 BCAM ACSL5	4.32e-05	191	148	6	6f5d91a9583bbb30dfaa30dd9c7772995a9196be
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B FOS FOXA2 LMNA BCAM SLC27A3	4.32e-05	191	148	6	4b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT BHMT2 KIFC3	4.32e-05	191	148	6	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 NCKAP5L SLC6A6 PTPRE BCAM TNS1	4.32e-05	191	148	6	8691eba35793e4e90f93d50c2145847ee51289f7
ToppCell	Severe-Myeloid-Macrophages-FABP4+\|Severe / Condition, Lineage, Cell class and cell subclass	HEXA HEXB SCCPDH LMNA PRDX1 TREM2	4.45e-05	192	148	6	30aad927ad40d8abaf9d0539bf8cb9d88d16f24d
ToppCell	E15.5-Epithelial-epithelial_progenitor_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXA2 PHGDH AGER PRDX1 BCAM ACSL5	4.45e-05	192	148	6	cb6f42dcffe650f7958543531d8f5412b2f2eb12
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOS CREB3L1 FREM1 HIVEP3 TNS1 SLC27A3	4.45e-05	192	148	6	e79f2253e084a9ab9afcaf7ec42a5012ade42d36
ToppCell	droplet-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOS SLC6A6 HMCN1 PRDX1 BCAM SF3B2	4.58e-05	193	148	6	07ddb9525b686c31fa7df4286557d1e58f7ead52
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOS CREB3L1 FREM1 HIVEP3 TNS1 SLC27A3	4.72e-05	194	148	6	f15e81ff12525523c62d13105cf264ea72205e2e
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	FLNB FOS SHROOM2 ARAP3 HMCN1 TMEM108	4.72e-05	194	148	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	FNDC3B PHGDH LMNA PRDX1 TNS1 SLC27A3	4.72e-05	194	148	6	40dbfdf1d7e6b73d120d8f802f08e573fe9a739e
ToppCell	proximal-Endothelial-Vein\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ACSL6 ITPR1 NBAS ZNF341 PPP1R3F SLC39A5	4.85e-05	195	148	6	0aebdd635a956dd2367883c1cf73d73ce9790635
ToppCell	proximal-3-Endothelial-Vein\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ACSL6 ITPR1 NBAS ZNF341 PPP1R3F SLC39A5	4.85e-05	195	148	6	c81eb541c15b866f9b6ca6a5f1751c5f1243f4fb
ToppCell	proximal-Endothelial-Vein-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ACSL6 ITPR1 NBAS ZNF341 PPP1R3F SLC39A5	4.85e-05	195	148	6	df00f94facc5d6107aac83cef3c64fefc7f8e562
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL15A1 OLFML2B FBXL22 LMNA TNS1 CCDC107	4.85e-05	195	148	6	56e7cd980f8fc2dae842e6a7bd919d4b41cebbbb
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL15A1 OLFML2B FBXL22 LMNA TNS1 CCDC107	4.85e-05	195	148	6	a28a504c69bc4dda7de023e1b4ea4f62390b158e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Slc17a8\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CREB3L1 PHGDH FREM1 SP8 TNS1	4.86e-05	119	148	5	6435891e6e33e7ae07e0c3a64a66edfbeedb54be
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B NID2 COL15A1 PI16 OLFML2B IGF1	4.99e-05	196	148	6	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FNDC3B FLNB APOBR JARID2 PTPN6 SYK	4.99e-05	196	148	6	a44a648bf209ce037bfc7b3adfcb220aab60728c
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HEXB ITPRIPL2 FOS SYK LTBR GNS	4.99e-05	196	148	6	28e9e191361966df3a9bd48450090577aa72a999
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A10 MYO7B CUBN BHMT BHMT2 SLC39A5	4.99e-05	196	148	6	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	T_cells-CD56_dim_CD16+_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FNDC3B APOBR PTPRE SYK KIFC3 IL2RB	4.99e-05	196	148	6	07b557b8530c19ca5b31ad2eac00c36ef1939266
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC3B NID2 COL15A1 PI16 OLFML2B IGF1	4.99e-05	196	148	6	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	368C-Fibroblasts-Fibroblast-I\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SDK2 CHI3L2 HIVEP3 INTS5 PTPRE KIFC3	5.14e-05	197	148	6	a3d5225b2b0dd5199f3c3f86713a05d48f1be8f4
ToppCell	Bronchial_Biopsy-Epithelial-Basal_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	FOS PHGDH SLC6A6 LMNA BCAM TNS1	5.14e-05	197	148	6	a4855c5aebea4f0fed4eb035844572e82e5bac46
ToppCell	COVID-19-COVID-19_Mild-Others-RBC\|COVID-19_Mild / Disease, condition lineage and cell class	COL15A1 RNF112 KIF24 FOXO4 BCAM TNS1	5.14e-05	197	148	6	3bae601e5d9689ea57e923814af8cdcae690becc
ToppCell	(4)_Endothelial_cells-(41)_EC-arteriolar\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	NID2 COL15A1 PRDX4 SLC6A6 LMNA BCAM	5.14e-05	197	148	6	482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCell	LPS_anti-TNF\|World / Treatment groups by lineage, cell group, cell type	HEXB OLFML2B FOS PTPN6 SYK ACSL5	5.14e-05	197	148	6	7768e613fa48a6ec4a3902559310b51345a7fe91
ToppCell	368C-Fibroblasts-Fibroblast-I-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SDK2 CHI3L2 HIVEP3 INTS5 PTPRE KIFC3	5.14e-05	197	148	6	d7a10eca2d810ab87dea570676f0b7041f99f017
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SDK2 COL15A1 EMID1 HIVEP3 HMCN1 TMEM108	5.14e-05	197	148	6	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
Drug	Alprostadil [745-65-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	EMID1 TNRC6B ORAI2 SLC6A6 HIVEP3 MZF1 SYK BCAM AFF4 PSD4	7.66e-07	197	150	10	7358_DN
Drug	dolichols	HEXA HEXB MAN2A1 LCT CD1A AHRR HCFC2 GNS	1.50e-06	122	150	8	CID000439223
Disease	autosomal recessive Emery-Dreifuss muscular dystrophy 3 (implicated_via_orthology)	LMNB2 LMNA	6.88e-05	3	142	2	DOID:0070248 (implicated_via_orthology)
Disease	Cor pulmonale (is_marker_for)	AGER IL27	6.88e-05	3	142	2	DOID:8515 (is_marker_for)
Disease	congenital muscular dystrophy due to LMNA mutation (implicated_via_orthology)	LMNB2 LMNA	6.88e-05	3	142	2	DOID:0110640 (implicated_via_orthology)
Disease	familial partial lipodystrophy type 2 (implicated_via_orthology)	LMNB2 LMNA	6.88e-05	3	142	2	DOID:0070202 (implicated_via_orthology)
Disease	autosomal dominant Emery-Dreifuss muscular dystrophy 2 (implicated_via_orthology)	LMNB2 LMNA	6.88e-05	3	142	2	DOID:0070247 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	FLNB COL15A1 LMNB2 LMNA	8.49e-05	48	142	4	DOID:423 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1A (implicated_via_orthology)	LMNB2 LMNA	1.37e-04	4	142	2	DOID:0110425 (implicated_via_orthology)
Disease	congenital muscular dystrophy (implicated_via_orthology)	LMNB2 LMNA	3.41e-04	6	142	2	DOID:0050557 (implicated_via_orthology)
Disease	Henoch-Schoenlein purpura (is_marker_for)	IGF1 IL27	4.75e-04	7	142	2	DOID:11123 (is_marker_for)
Disease	ascending aortic diameter	FLNB TNRC6B HIVEP3 HMCN1 HYDIN	5.96e-04	140	142	5	EFO_0021787
Disease	progeria (implicated_via_orthology)	LMNB2 LMNA	6.32e-04	8	142	2	DOID:3911 (implicated_via_orthology)
Disease	kidney disease (implicated_via_orthology)	NPHS1 CUBN LCT	1.02e-03	41	142	3	DOID:557 (implicated_via_orthology)
Disease	smoking behaviour measurement, waist-hip ratio	MGMT BCAM	1.23e-03	11	142	2	EFO_0004343, EFO_0005671
Disease	homocysteine measurement	C1orf167 CUBN PRDX1	1.42e-03	46	142	3	EFO_0004578
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	LMNB2 LMNA	1.47e-03	12	142	2	DOID:11726 (implicated_via_orthology)
Disease	taurodeoxycholate measurement	BRD8 SMIM36	1.47e-03	12	142	2	EFO_0010539
Disease	Malignant neoplasm of breast	FNDC3B NID2 FLNB ERBB3 CTU2 FOS UBR4 CUBN SHROOM2 PHGDH IGF1 ARAP3 TNS1	2.10e-03	1074	142	13	C0006142
Disease	myopia (is_implicated_in)	IGF1 SLC39A5	2.64e-03	16	142	2	DOID:11830 (is_implicated_in)
Disease	IGF-1 measurement, IGFBP-3 measurement	IGF1 CELSR2	2.98e-03	17	142	2	EFO_0004626, EFO_0004627
Disease	cystic fibrosis (is_marker_for)	IGF1 AGER MUC2	3.35e-03	62	142	3	DOID:1485 (is_marker_for)
Disease	carotid artery disease (is_marker_for)	IGF1 AGER	3.73e-03	19	142	2	DOID:3407 (is_marker_for)
Disease	hydrocephalus (implicated_via_orthology)	CELSR2 HYDIN	3.73e-03	19	142	2	DOID:10908 (implicated_via_orthology)
Disease	leprosy, Crohn's disease	CCDC88B IL27	4.13e-03	20	142	2	EFO_0000384, EFO_0001054
Disease	citrulline measurement	HMCN2 PTPRE	4.13e-03	20	142	2	EFO_0009777
Disease	hepatitis B (is_marker_for)	IL2RB IL27	4.55e-03	21	142	2	DOID:2043 (is_marker_for)
Disease	muscular dystrophy (implicated_via_orthology)	LMNB2 LMNA	4.55e-03	21	142	2	DOID:9884 (implicated_via_orthology)
Disease	anorexia nervosa	ERBB3 MGMT CELSR3	4.72e-03	70	142	3	MONDO_0005351

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSVVSGLNSGPGHVW	PI16	431	Q6UXB8
KSGPLPPGGWDDSHL	SLC33A1	26	O00400
TKPLPWTAGKHSEDG	AHRR	401	A9YTQ3
LPPASEKHGSWGSGL	BHMT	321	Q93088
VTGSGGPFKSDPHWE	FAM234A	296	Q9H0X4
GSGVFGTVHKGVWIP	ERBB3	716	P21860
GSSGPHKLPWGPLLS	C1orf167	331	Q5SNV9
WPKDGGNGTSPDFSH	CREB3L1	486	Q96BA8
SHTAPAPGLWLSGFG	ARAP3	811	Q8WWN8
VSHSKGPGVGWENSA	CCDC88B	1431	A6NC98
GKHKLLSTGPTEPWS	BRD8	6	Q9H0E9
GGHWSPSLDGPDPEK	CCAR1	501	Q8IX12
AHTGAWGTGLPAPHV	DUX4L4	181	P0CJ87
HKLPSTGADPWGASL	EPN3	396	Q9H201
DPLLASWHGGTGTSP	AJM1	421	C9J069
AKGSSPEGLPAWVLG	CEP112	111	Q8N8E3
GSWEKPLITGHNSPL	CHI3L2	216	Q15782
PFVPGGVSDGQWHTV	CELSR2	1441	Q9HCU4
GKAPWPGDFGTTAKE	CELSR2	2786	Q9HCU4
AHTGAWGTGLPAPHV	DUX4L6	181	P0CJ89
GSHQSSKWTPVGPAP	AFF4	101	Q9UHB7
PAGTLSWHLDGKPLV	AGER	151	Q15109
TNHVGGKGPPSASWF	INTS6L	641	Q5JSJ4
HAWTGVPGGTPDCLT	IQCE	101	Q6IPM2
PGPGSHTGWQAALVS	ORAI2	186	Q96SN7
PWVKASPVGAHAGEG	MLX	11	Q9UH92
GRPHPTLKGTWQSGF	ACACB	2051	O00763
IPVPDGSEGTIHQWG	DSG3	656	P32926
SLTPHSVGLEWKPGF	NPHS1	951	O60500
HFHGWPEIGIPAEGK	PTPRE	591	P23469
GAGATHSPPTDLVWK	LMNA	501	P02545
GAVAKEWGTTPAGPV	MAP3K10	6	Q02779
GGWVPHKGENTETSP	HCFC2	261	Q9Y5Z7
AHTGAWGTGLPAPHV	DUX4	181	Q9UBX2
KPRSGWAIDPFGHSP	MAN2A1	281	Q16706
LPKSAWGGGTPEAHR	NCKAP5L	376	Q9HCH0
SSAHPWGLVGKSNPK	SLC24A1	291	O60721
ADWEPLHSGSLGMGP	FOS	301	P01100
KGVRGGTLEPHWSGL	ITPR1	2306	Q14643
WVKSTQGGPEHASPP	MAPK4	496	P31152
LPGSHPATWSAGGII	SYK	276	P43405
THQLWGGPPFHTPKE	HMCN2	381	Q8NDA2
AGVAHSPPSTLVWKG	LMNB2	536	Q03252
LHSGIPGTEGWMAPE	ERN2	676	Q76MJ5
WLKGAGATSGSPPAG	MGMT	191	P16455
QVKPEAWLSHGPSPG	CD1A	201	P06126
AHTGAWGTGLPAPHV	DUX4L3	181	P0CJ86
GGALKPTRSGTKWVH	JADE2	261	Q9NQC1
QAGDTWSPDLHPVGG	FAM53B	206	Q14153
AITWGGHHIPKSPFE	FLNB	526	O75369
ATPTSPVGHFAKWSG	FOXO4	226	P98177
GIPGLESSHSWLSGP	OR51I2	16	Q9H344
WLDSGKPNFHKPGGD	MUC2	1791	Q02817
PTGPGAWTASKLGGI	PDCD2L	21	Q9BRP1
APKIPSVSWHDVGGL	PEX6	696	Q13608
AHPVGSPGESGTSGW	EFNA4	161	P52798
KGIWHLLPPGSSSST	FREM1	1871	Q5H8C1
GATQPHKEWVPKGDG	PNPLA1	306	Q8N8W4
HLWLSSSPPDNKPGG	KIF24	1111	Q5T7B8
SGKGSWPHLSLEPIG	EVC2	1236	Q86UK5
GKGPSIWDNFTHTPG	LCT	926	P09848
WTPQEHPGLSGEAVG	GOLGA6L4	531	A6NEF3
GWTPQEHPGLSGEAV	GOLGA6L19	506	H0YKK7
AGGKTSLGPPGSWTL	MSLNL	221	Q96KJ4
WEGGDPGVAHQKTPT	HSPA12B	91	Q96MM6
WSGTGHPSEILGLSP	MEIOSIN	351	C9JSJ3
WTGDPHLIKQVPGSS	NBAS	1856	A2RRP1
SGVPFPSIHWTKNGI	HMCN1	3921	Q96RW7
TDKHGEVCPAGWKPG	PRDX1	166	Q06830
GIPGVWAFHIGSTSP	NID2	261	Q14112
IVGTHGKVASPFWPE	CUBN	1856	O60494
PAHSLGDLKGSWPGR	FAM189B	571	P81408
GDHSLEVEAGLPPGW	APBB3	21	O95704
APGTGSWAEGSVKAP	FCAMR	246	Q8WWV6
GPIHRWLSVSPSVGG	HYDIN	2186	Q4G0P3
FLPPASEKHGSWGSG	BHMT2	311	Q9H2M3
AVAKGPSHSLGWEGG	CCDC107	256	Q8WV48
PCIKAISPGEGWTTG	EBF4	256	Q9BQW3
GSPGTRSKALVPGEW	COL20A1	1236	Q9P218
KGPVTSHGFSVKWDP	FNDC3B	581	Q53EP0
AHTGAWGTGLPAPHV	DUX4L9	181	Q6RFH8
KAGHSVWPLGFPTLS	IL27	226	Q8NEV9
HGGDVQKWLSSPFPS	IL2RB	296	P14784
LPGDWTSGHVGVPLA	ACSL5	456	Q9ULC5
AHTGAWGTGLPAPHV	DUX4L7	181	P0CJ90
APDAGGLEHVPLGWS	GNS	156	P15586
GWPKTHPGGEQKEGT	IGF1	151	P05019
GHVDGPIWGLATHPS	EML5	1691	Q05BV3
PKGDPGEKSHWGEGL	EMID1	361	Q96A84
GWDPGLAATTGPRAH	CELSR3	41	Q9NYQ7
AHTGAWGTGLPAPHV	DUX4L5	181	P0CJ88
LPEFDTPGHTLSWGK	HEXB	286	P07686
RGHPDPKLSWSQLGG	BCAM	476	P50895
TFHGVKGEKGSWGLP	COL15A1	981	P39059
HIAAKAWGSLQGPPV	SERHL2	21	Q9H4I8
AIHWSSGDPGKGPIT	SDK2	1841	Q58EX2
PGEKVLLAWSGGPSS	CTU2	71	Q2VPK5
GFPVGKSEPFSRHGW	JARID2	876	Q92833
LKAPPSPSGASGGHW	ITPRIPL2	211	Q3MIP1
PKGPWSSTGHVQFGK	MTX1	16	Q13505
KPGKGSFWTLHPDSG	FOXA2	226	Q9Y261
EFDTPGHTLSWGPGI	HEXA	256	P06865
HIAAKAWGSLQGPPV	SERHL	21	Q9NQF3
ASEPSPGGIKWGHLF	RUSC2	1376	Q8N2Y8
SQKKPSHLGPLDGSW	TRMT2B	66	Q96GJ1
KPPSSGSGWGDHPAE	TNRC6C	836	Q9HCJ0
LSPGIDHPGSLKWDL	SLC6A6	206	P31641
PLVLSLHGWTGTGKS	TOR2A	86	Q8N2E6
HGEVCPAGWKPGSET	PRDX4	241	Q13162
VLFHLKGQDWPPGSG	TMEM132A	141	Q24JP5
GPEGLSIHDGTWKSA	SCCPDH	186	Q8NBX0
WPGALGGPERVTFHS	NTN5	111	Q8WTR8
FPTFPSWLGKHSSTG	RFC1	956	P35251
ALSVDWAGPGSPHGL	KIFC3	86	Q9BVG8
VGPKSPRWGGPDHSE	FBXL22	141	Q6P050
PWGSGVELTHLGSPS	PSD4	106	Q8NDX1
SVAGPHWPKGPGLSL	SMIM36	66	A0A1B0GVT2
PWGFTLKGGREHGEP	SHROOM2	36	Q13796
PKGRSPLSWGSLFGH	SLC35E2A	21	P0CK97
TAAVPGPGGIWSVFH	INTS5	736	Q6P9B9
SLGKDAPAGWGTTPA	OLFML2B	461	Q68BL8
ESWFKPSHPGLGAAG	SP8	186	Q8IXZ3
PLGPSGWGDLEESKA	SLC39A5	111	Q6ZMH5
GTPGGTPAGDKVASW	SMARCD2	216	Q92925
TPGDWTSGHVGAPLP	ACSL6	471	Q9UKU0
TWHGETEGKAGAVGP	APOBR	201	Q0VD83
WGGLTHSVTKGQGPE	APOBR	551	Q0VD83
TTLPSHIPGKGGSWE	PNMA5	76	Q96PV4
PLVLSLHGWTGTGKS	TOR2A	86	Q5JU69
HAGGWGKPPVDETGK	SF3B2	666	Q13435
THKVWPPGHSGGTVS	ZNF341	371	Q9BYN7
QTDGVPWTPSPKHSG	TICRR	1661	Q7Z2Z1
SWSHTPFPKLELGLG	RNF112	31	Q9ULX5
PHTGDLPWTGMTFGL	SLC5A10	256	A0PJK1
HLWAAGPGTHPAGIS	SLC27A3	241	Q5K4L6
GSETPGATPGSKIWD	SF3B1	241	O75533
GATPGSKIWDPTPSH	SF3B1	246	O75533
TPKTERDTPGHGSGW	SF3B1	296	O75533
LSEHWALPGGSREPG	TRPM2	1381	O94759
APLHKSQSVPGAWPG	TNS1	726	Q9HBL0
VASGHSAWISKPPGV	SOX10	326	P56693
WLGPAPLGSVEKDTG	HIVEP3	1941	Q5T1R4
SPGHAAPLLPGGWVT	PRRT4	641	C9JH25
WAGSLDPISGKEPAS	PPP1R3F	681	Q6ZSY5
PKGRSPLSWGSLFGH	SLC35E2B	21	P0CK96
AGPSLTEKPWALGAG	TET3	1526	O43151
AAWHGQKPGTHPPSE	TREM2	196	Q9NZC2
HGGSPIHWVLPAGMS	YTHDC1	421	Q96MU7
SWPDHGVPSEPGGVL	PTPN6	416	P29350
PPGLSTPHQEDGKAW	LTBR	396	P36941
SPHTKPWIGLAEALG	PHGDH	326	O43175
LHKGWETDGPPAALS	UBR4	496	Q5T4S7
AADITGPTPHQGGWK	WASH6P	21	Q9NQA3
GGHTGPAGDSWLPAK	TNRC6B	1446	Q9UPQ9
WLIPIGSSPGDGHSF	ZDHHC15	281	Q96MV8
AGTWKPGTAGNISHV	TMEM108	436	Q6UXF1
DAHGGSIPLGKSWVS	ZAN	2271	Q9Y493
AHTGAWGTGLPAPHV	DUX4L2	181	P0CJ85
WLEPPSTHKTGVAIG	MYO7B	11	Q6PIF6
IFPHSKTGPEGPSWR	MZF1	226	P28698