Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	CETN3 GNAI2 GNAI3	6.24e-05	25	62	3	GO:0031683
GeneOntologyMolecularFunction	keratin filament binding	KRT74 SIRT1	1.41e-04	6	62	2	GO:1990254
GeneOntologyMolecularFunction	deacetylase activity	ADPRS SUDS3 SIRT1	2.59e-04	40	62	3	GO:0019213
GeneOntologyMolecularFunction	intermediate filament binding	KRT74 SIRT1	9.70e-04	15	62	2	GO:0019215
GeneOntologyMolecularFunction	misfolded protein binding	TMEM67 STUB1	1.41e-03	18	62	2	GO:0051787
GeneOntologyMolecularFunction	cytoskeletal protein binding	CCDC88C TMEM67 ANK1 STUB1 CLASP1 CETN3 IFT81 CKAP5 DIAPH3 MYO5C	1.93e-03	1099	62	10	GO:0008092
GeneOntologyMolecularFunction	tubulin binding	CCDC88C CLASP1 CETN3 IFT81 CKAP5 DIAPH3	2.09e-03	428	62	6	GO:0015631
GeneOntologyMolecularFunction	microtubule plus-end binding	CLASP1 CKAP5	2.11e-03	22	62	2	GO:0051010
GeneOntologyMolecularFunction	histone deacetylase activity	SUDS3 SIRT1	2.51e-03	24	62	2	GO:0004407
GeneOntologyMolecularFunction	microtubule binding	CCDC88C CLASP1 CETN3 CKAP5 DIAPH3	2.67e-03	308	62	5	GO:0008017
GeneOntologyMolecularFunction	protein lysine deacetylase activity	SUDS3 SIRT1	2.72e-03	25	62	2	GO:0033558
GeneOntologyMolecularFunction	R-SMAD binding	PARP1 STUB1	2.94e-03	26	62	2	GO:0070412
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	PARP1 SIRT1	3.40e-03	28	62	2	GO:0003950
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	PARP1 SIRT1	3.90e-03	30	62	2	GO:1990404
GeneOntologyMolecularFunction	lysine-acetylated histone binding	ZZZ3 SIRT1	3.90e-03	30	62	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	ZZZ3 SIRT1	4.16e-03	31	62	2	GO:0140033
GeneOntologyMolecularFunction	protein domain specific binding	GRIP1 CCDC88C LONP1 STUB1 ERC1 GNAI3 SRSF9 SIRT1	5.48e-03	875	62	8	GO:0019904
GeneOntologyMolecularFunction	PDZ domain binding	GRIP1 CCDC88C ERC1	6.62e-03	123	62	3	GO:0030165
GeneOntologyBiologicalProcess	microtubule organizing center organization	TMEM67 CLASP1 CETN3 RBM14 CKAP5 SIRT1	1.77e-05	179	63	6	GO:0031023
GeneOntologyBiologicalProcess	regulation of microtubule-based process	CCDC88C TMEM67 CLASP1 RBM14 CKAP5 DIAPH3 SIRT1	3.04e-05	293	63	7	GO:0032886
GeneOntologyBiologicalProcess	regulation of organelle organization	CCDC88C TMEM67 PARP1 SFPQ ANK1 STUB1 CLASP1 ERC1 VPS13C ENTR1 RBM14 CKAP5 DIAPH3 SIRT1	4.18e-05	1342	63	14	GO:0033043
GeneOntologyBiologicalProcess	microtubule depolymerization	CCDC88C CLASP1 CKAP5 DIAPH3	4.94e-05	66	63	4	GO:0007019
GeneOntologyBiologicalProcess	microtubule-based process	CCDC88C TMEM67 SFPQ CLASP1 CETN3 IFT81 AP3B2 RBM14 CKAP5 KATNIP DIAPH3 SIRT1	7.35e-05	1058	63	12	GO:0007017
GeneOntologyBiologicalProcess	thyroid-stimulating hormone secretion	SLC16A2 SIRT1	9.13e-05	5	63	2	GO:0070460
GeneOntologyBiologicalProcess	cellular response to heat	STUB1 PDCL3 SLU7 SIRT1	1.10e-04	81	63	4	GO:0034605
GeneOntologyBiologicalProcess	centrosome duplication	TMEM67 RBM14 CKAP5 SIRT1	1.10e-04	81	63	4	GO:0051298
GeneOntologyBiologicalProcess	centrosome cycle	TMEM67 CETN3 RBM14 CKAP5 SIRT1	1.45e-04	164	63	5	GO:0007098
GeneOntologyBiologicalProcess	negative regulation of microtubule depolymerization	CCDC88C CLASP1 DIAPH3	2.12e-04	38	63	3	GO:0007026
GeneOntologyCellularComponent	microtubule organizing center	CCDC88C TMEM67 CLASP1 ERC1 CEP112 CETN3 IFT81 ENTR1 CKAP5 GNAI2 GNAI3 DIAPH3	1.38e-05	919	62	12	GO:0005815
GeneOntologyCellularComponent	centrosome	CCDC88C TMEM67 CLASP1 ERC1 CEP112 CETN3 IFT81 ENTR1 CKAP5 GNAI2 GNAI3	1.44e-05	770	62	11	GO:0005813
GeneOntologyCellularComponent	cytoplasmic region	UNC13B TMEM67 SFPQ CLASP1 ERC1 AP3B2 CKAP5	9.24e-05	360	62	7	GO:0099568
GeneOntologyCellularComponent	cell cortex region	UNC13B CLASP1 ERC1	3.23e-04	45	62	3	GO:0099738
Domain	CLASP_N	CLASP1 CKAP5	7.12e-05	4	65	2	PF12348
Domain	CLASP_N_dom	CLASP1 CKAP5	7.12e-05	4	65	2	IPR024395
Domain	Gprotein_alpha_I	GNAI2 GNAI3	3.29e-04	8	65	2	IPR001408
Domain	G-alpha	GNAI2 GNAI3	1.39e-03	16	65	2	PF00503
Domain	GproteinA_insert	GNAI2 GNAI3	1.39e-03	16	65	2	IPR011025
Domain	-	GNAI2 GNAI3	1.39e-03	16	65	2	1.10.400.10
Domain	G_alpha	GNAI2 GNAI3	1.39e-03	16	65	2	SM00275
Domain	HEAT_type_2	CLASP1 CKAP5	1.57e-03	17	65	2	IPR021133
Domain	Gprotein_alpha_su	GNAI2 GNAI3	1.57e-03	17	65	2	IPR001019
Domain	-	LONP1 TOP2B	2.40e-03	21	65	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	LONP1 TOP2B	2.63e-03	22	65	2	IPR014721
Domain	Ribosomal_S5_D2-typ_fold	LONP1 TOP2B	6.23e-03	34	65	2	IPR020568
Domain	ARM-type_fold	USP34 CLASP1 AP3B2 CKAP5 DIAPH3	6.49e-03	339	65	5	IPR016024
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI2 GNAI3	3.01e-04	8	47	2	M47642
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI2 GNAI3	3.01e-04	8	47	2	M47643
Pathway	REACTOME_POLB_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR	PARP1 ADPRS	3.01e-04	8	47	2	M26901
Pathway	KEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI2 GNAI3	3.86e-04	9	47	2	M47641
Pathway	REACTOME_POLB_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR	PARP1 ADPRS	3.86e-04	9	47	2	MM14480
Pathway	KEGG_MEDICUS_REFERENCE_BASE_EXCISION_AND_STRAND_CLEAVAGE_BY_BIFUNCTIONAL_GLYCOSYLASE	PARP1 ADPRS	3.86e-04	9	47	2	M47829
Pathway	WP_NAD_METABOLISM_SIRTUINS_AND_AGING	PARP1 SIRT1	5.87e-04	11	47	2	M39439
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	GNAI2 GNAI3	5.87e-04	11	47	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	GNAI2 GNAI3	7.03e-04	12	47	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	GNAI2 GNAI3	7.03e-04	12	47	2	M47559
Pathway	PID_S1P_S1P4_PATHWAY	GNAI2 GNAI3	9.65e-04	14	47	2	M64
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAI2 GNAI3	9.65e-04	14	47	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAI2 GNAI3	9.65e-04	14	47	2	M750
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP34 PARP1 ST13P4 LONP1 SFPQ STUB1 SUDS3 RBM14 PHAX SRSF9 SIRT1 TOP2B XAB2	4.11e-08	1014	65	13	32416067
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	GRIP1 CCDC88C LONP1 STUB1 ERC1 VPS13C IFT81 PDCL3 ENTR1 RBM14 CKAP5 GNAI3	5.36e-08	853	65	12	28718761
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	UNC13B USP34 MRM3 PARP1 LONP1 SFPQ STUB1 WDR87 ENTR1 RBM14 PHAX SRSF9 SIRT1	9.48e-07	1335	65	13	29229926
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP34 ZZZ3 STUB1 CLASP1 ERC1 ENTR1 RBM14 DIAPH3 SIRT1	1.46e-06	588	65	9	38580884
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MRM3 PARP1 LONP1 SFPQ SLC4A7 STUB1 CLASP1 ERC1 RBM14 CKAP5 DIAPH3 TOP2B XAB2	1.81e-06	1415	65	13	28515276
Pubmed	Human transcription factor protein interaction networks.	FHAD1 ST13P4 LONP1 ZZZ3 STUB1 SUDS3 KRT74 ENTR1 SLU7 GFPT2 SIRT1 MYO5C FILIP1L	2.02e-06	1429	65	13	35140242
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	CCDC88C GNAI2 GNAI3	2.79e-06	15	65	3	36260679
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	MRM3 PARP1 SFPQ SUDS3 RBM14 GFPT2 PHAX SRSF9 XAB2	3.44e-06	653	65	9	33742100
Pubmed	Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.	GNAI2 GNAI3	3.44e-06	2	65	2	25944935
Pubmed	PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress.	PARP1 SIRT1	3.44e-06	2	65	2	32732457
Pubmed	Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.	GNAI2 GNAI3	3.44e-06	2	65	2	17289675
Pubmed	Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils.	GNAI2 GNAI3	3.44e-06	2	65	2	26976957
Pubmed	Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.	PARP1 ADPRS	3.44e-06	2	65	2	29234005
Pubmed	Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.	GNAI2 GNAI3	3.44e-06	2	65	2	11073886
Pubmed	Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.	PARP1 SIRT1	3.44e-06	2	65	2	24814482
Pubmed	Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.	GNAI2 GNAI3	3.44e-06	2	65	2	24858945
Pubmed	Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism.	PARP1 SIRT1	3.44e-06	2	65	2	25361036
Pubmed	Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.	GNAI2 GNAI3	3.44e-06	2	65	2	18521956
Pubmed	FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.	GNAI2 GNAI3	3.44e-06	2	65	2	21788441
Pubmed	A small multigene family encodes Gi signal-transduction proteins.	GNAI2 GNAI3	3.44e-06	2	65	2	3120178
Pubmed	Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity.	GNAI2 GNAI3	3.44e-06	2	65	2	11158953
Pubmed	Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.	PARP1 SIRT1	3.44e-06	2	65	2	19672559
Pubmed	Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator.	STUB1 DIAPH3	3.44e-06	2	65	2	39322015
Pubmed	Gαi2 is the essential Gαi protein in immune complex-induced lung disease.	GNAI2 GNAI3	3.44e-06	2	65	2	23225882
Pubmed	Canonical and noncanonical g-protein signaling helps coordinate actin dynamics to promote macrophage phagocytosis of zymosan.	GNAI2 GNAI3	3.44e-06	2	65	2	25225330
Pubmed	An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver.	GNAI2 GNAI3	3.44e-06	2	65	2	17296938
Pubmed	Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.	PARP1 SIRT1	3.44e-06	2	65	2	20493163
Pubmed	PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity.	PARP1 SIRT1	3.44e-06	2	65	2	20060806
Pubmed	Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.	GNAI2 GNAI3	3.44e-06	2	65	2	17360531
Pubmed	Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.	GNAI2 GNAI3	3.44e-06	2	65	2	21966394
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	USP34 PARP1 SFPQ RBM14 SRSF9 TOP2B	3.62e-06	220	65	6	35785414
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UNC13B USP34 PARP1 MAN1A2 STUB1 ERC1 HLA-DRA IFT81 CKAP5 RNF216 GFPT2 XAB2	4.05e-06	1285	65	12	35914814
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GRIP1 CCDC88C STIM2 SLC4A7 CLASP1 ERC1 CEP112 RBM14 CKAP5 PFKFB2	4.29e-06	861	65	10	36931259
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	USP34 CLASP1 ERC1 VPS13C CKAP5	4.32e-06	128	65	5	30995482
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	SFPQ STUB1 CKAP5 GNAI2 GNAI3 TOP2B	4.79e-06	231	65	6	36597993
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 SFPQ SLC4A7 CEP112 SBF2 SLU7 GNAI3 GFPT2 DSE TIAM2 SBNO2	4.92e-06	1084	65	11	11544199
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	CCDC88C MRM3 PARP1 SFPQ RBM14 CKAP5 PFKFB2 XAB2	8.62e-06	551	65	8	34728620
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	CCDC88C GNAI2 GNAI3	9.35e-06	22	65	3	34001891
Pubmed	Serine is the major residue for ADP-ribosylation upon DNA damage.	PARP1 ADPRS	1.03e-05	3	65	2	29480802
Pubmed	Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.	GNAI2 GNAI3	1.03e-05	3	65	2	16962188
Pubmed	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.	PARP1 ADPRS	1.03e-05	3	65	2	34625544
Pubmed	GAP1(IP4BP)/RASA3 mediates Galphai-induced inhibition of mitogen-activated protein kinase.	GNAI2 GNAI3	1.03e-05	3	65	2	18952607
Pubmed	The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome.	GNAI2 GNAI3	1.03e-05	3	65	2	23977324
Pubmed	G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes.	GNAI2 GNAI3	1.03e-05	3	65	2	18156202
Pubmed	Stabilization of C5a receptor--G-protein interactions through ligand binding.	GNAI2 GNAI3	1.03e-05	3	65	2	7962171
Pubmed	71.67 T lymphocyte activation is accompanied by the down-regulation of three G alpha genes.	GNAI2 GNAI3	1.03e-05	3	65	2	7656338
Pubmed	Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.	GNAI2 GNAI3	1.03e-05	3	65	2	15788486
Pubmed	Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion.	PARP1 SIRT1	1.03e-05	3	65	2	25517228
Pubmed	RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway.	GNAI2 GNAI3	1.03e-05	3	65	2	30233409
Pubmed	The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus.	GNAI2 GNAI3	1.03e-05	3	65	2	8663053
Pubmed	Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.	GNAI2 GNAI3	1.03e-05	3	65	2	17484771
Pubmed	Requirement of Galphai in thymic homing and early T cell development.	GNAI2 GNAI3	1.03e-05	3	65	2	18501427
Pubmed	A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites.	PARP1 SIRT1	1.03e-05	3	65	2	31291457
Pubmed	Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.	GNAI2 GNAI3	1.03e-05	3	65	2	29342363
Pubmed	Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation.	GNAI2 GNAI3	1.03e-05	3	65	2	11055978
Pubmed	TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.	GNAI2 GNAI3	1.03e-05	3	65	2	20607800
Pubmed	Loss of Gαi proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4+PD-1+CXCR5+/- T-cells.	GNAI2 GNAI3	1.03e-05	3	65	2	28646160
Pubmed	Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.	PARP1 SIRT1	1.03e-05	3	65	2	16207712
Pubmed	Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.	GNAI2 GNAI3	1.03e-05	3	65	2	17418106
Pubmed	GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.	GNAI2 GNAI3	1.03e-05	3	65	2	30836096
Pubmed	TopoisomeraseIIβ in HIV-1 transactivation.	PARP1 TOP2B	1.03e-05	3	65	2	26876283
Pubmed	NAD+-mediated regulation of mammalian base excision repair.	PARP1 SIRT1	1.03e-05	3	65	2	33087267
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PARP1 STIM2 SFPQ ERC1 CEP112 KRT74 IFT81 GNAI2 GNAI3 DIAPH3 TEX35 TOP2B	1.29e-05	1442	65	12	35575683
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	USP34 PARP1 SFPQ MAN1A2 SLC4A7 CLASP1 CKAP5 RNF216 GNAI3 TOP2B RCN3	1.31e-05	1203	65	11	29180619
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	PARP1 ENTR1 RBM14 SRSF9	1.43e-05	78	65	4	28611094
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PARP1 SFPQ SLU7 PHAX TOP2B XAB2	1.52e-05	283	65	6	30585729
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	PARP1 SFPQ SLC4A7 RBM14 GNAI2 GNAI3 SRSF9 TOP2B	1.67e-05	604	65	8	37616343
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MRM3 PARP1 LONP1 STIM2 SFPQ SLC4A7 STUB1 VPS13C PDCL3 DIAPH3 SRSF9 SIRT1	1.87e-05	1496	65	12	32877691
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PARP1 LONP1 SFPQ RBM14 CKAP5 GNAI2 SRSF9 TOP2B XAB2 MYO5C	1.93e-05	1024	65	10	24711643
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	PARP1 SFPQ RBM14	1.97e-05	28	65	3	19596686
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	GRIP1 CCDC88C LONP1 CLASP1 ERC1 ENTR1 PFKFB2	2.00e-05	446	65	7	24255178
Pubmed	p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells.	PARP1 SIRT1	2.06e-05	4	65	2	18230337
Pubmed	Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.	GNAI2 GNAI3	2.06e-05	4	65	2	11248120
Pubmed	Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.	PARP1 SIRT1	2.06e-05	4	65	2	16628003
Pubmed	An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation.	PARP1 ADPRS	2.06e-05	4	65	2	33186521
Pubmed	Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.	GNAI2 GNAI3	2.06e-05	4	65	2	17635935
Pubmed	Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.	GNAI2 GNAI3	2.06e-05	4	65	2	20508603
Pubmed	Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins.	GNAI2 GNAI3	2.06e-05	4	65	2	11771389
Pubmed	PARP1 regulates the protein stability and proapoptotic function of HIPK2.	PARP1 STUB1	2.06e-05	4	65	2	27787517
Pubmed	Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors.	GNAI2 GNAI3	2.06e-05	4	65	2	12297509
Pubmed	CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.	GNAI2 GNAI3	2.06e-05	4	65	2	11168387
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B ERC1	2.06e-05	4	65	2	28264913
Pubmed	The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.	GNAI2 GNAI3	2.06e-05	4	65	2	18832081
Pubmed	Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.	PARP1 SIRT1	2.06e-05	4	65	2	28970491
Pubmed	Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.	GNAI2 GNAI3	2.06e-05	4	65	2	21931697
Pubmed	The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia.	PARP1 SFPQ	2.06e-05	4	65	2	18445785
Pubmed	Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.	GNAI2 GNAI3	2.06e-05	4	65	2	28145731
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	USP34 STIM2 SFPQ SLC4A7 RBM14	2.26e-05	180	65	5	35198878
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	SFPQ RBM14 SIRT1 XAB2	2.41e-05	89	65	4	22446626
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	SFPQ STUB1 RBM14	2.44e-05	30	65	3	34017080
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	PARP1 SFPQ STUB1 KRT74 RBM14 GNAI3 SRSF9 TOP2B	2.55e-05	641	65	8	36057605
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 SLC4A7 CLASP1 GNAI2 GNAI3 GFPT2	3.14e-05	322	65	6	26514267
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MRM3 PARP1 SFPQ RBM14 GNAI2 GNAI3 SRSF9 TOP2B	3.14e-05	660	65	8	32780723
Pubmed	Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.	PARP1 GFPT2	3.43e-05	5	65	2	20353610
Pubmed	Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor.	GNAI2 GNAI3	3.43e-05	5	65	2	12860983
Pubmed	Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.	GNAI2 GNAI3	3.43e-05	5	65	2	10598579
Pubmed	Coupling of dopamine receptor subtypes to multiple and diverse G proteins.	GNAI2 GNAI3	3.43e-05	5	65	2	10978845
Pubmed	An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.	GNAI2 GNAI3	3.43e-05	5	65	2	26373672
Pubmed	Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.	PARP1 TOP2B	3.43e-05	5	65	2	21228215
Pubmed	G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).	GNAI2 GNAI3	3.43e-05	5	65	2	16298104
Interaction	NIN interactions	LONP1 CLASP1 ERC1 IFT81 ENTR1 RBM14 CKAP5 GNAI3 DIAPH3	2.17e-06	359	65	9	int:NIN
Interaction	AR interactions	GRIP1 USP34 PARP1 SFPQ STUB1 SUDS3 VPS13C RBM14 GNAI3 SRSF9 SIRT1 TOP2B XAB2 MYO5C	2.60e-06	992	65	14	int:AR
Interaction	AGTR2 interactions	PARP1 GNAI2 GNAI3	2.11e-05	17	65	3	int:AGTR2
Interaction	CNTRL interactions	LONP1 CLASP1 ERC1 IFT81 ENTR1 CKAP5	3.69e-05	193	65	6	int:CNTRL
Cytoband	1p13	MAN1A2 GNAI3	2.65e-04	17	65	2	1p13
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC16A2 HLA-DRA RBM14 DSE TIAM2	5.03e-06	173	64	5	b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC16A2 RBM14 RIPOR3 KATNIP DSE	5.47e-06	176	64	5	437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCell	facs-Heart-RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 SLC16A2 DSE RCN3 FILIP1L	9.46e-06	197	64	5	940cf1e54d7c820e04946258a8b784f35c6a144c
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PARP1 STIM2 SFPQ HLA-DRA TOP2B	9.69e-06	198	64	5	5f465cf5c7493e32d9afe9e9d05757d0a95acc33
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PARP1 STIM2 SFPQ HLA-DRA TOP2B	9.69e-06	198	64	5	77ce3fe1ab161c0faf8987e73a64ab61294b9255
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	GRIP1 USP34 CLASP1 ERC1 SBF2	9.93e-06	199	64	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GALNTL6 ANK1 IRAG1 FILIP1L	3.27e-05	126	64	4	3539a8fdbb52d191f36dce68c38798ad4d2b491a
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	GALNTL6 SLC16A2 PFKFB2 MYO5C	7.15e-05	154	64	4	8a8c3851888ab86ca2b13ccc042cde1fef8d88f8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GALNTL6 ANK1 IRAG1 FILIP1L	8.09e-05	159	64	4	c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PARP1 ANK1 HLA-DRA SRSF9	8.70e-05	162	64	4	3e15b3e97a2ade86d0cb0ab15fccb9a2e2e27dd4
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 CEP112 LRRC2 GFPT2	9.56e-05	166	64	4	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 CEP112 LRRC2 GFPT2	9.56e-05	166	64	4	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GRIP1 GALNTL6 ANK1 GFPT2	9.78e-05	167	64	4	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CEP112 WDR87 CKAP5 DIAPH3	1.02e-04	169	64	4	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 CEP112 LRRC2 IRAG1	1.02e-04	169	64	4	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GRIP1 GALNTL6 ANK1 GFPT2	1.02e-04	169	64	4	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	MRM3 LRRC2 SIRT1 TIAM2	1.10e-04	172	64	4	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP112 VPS13C CKAP5 TOP2B	1.20e-04	176	64	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM67 ANK1 KLHL41 IRAG1	1.20e-04	176	64	4	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRIP1 SLC4A7 ADAM29 MYO5C	1.20e-04	176	64	4	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	B_cell_maturation-CD34+_pre-plamsa\|World / Lineage and Cell class	SLC16A2 HLA-DRA TOP2B MYO5C	1.22e-04	177	64	4	3ff06100deee9bee852a52078666999a9f7beaf1
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C SFPQ VPS13C FILIP1L	1.25e-04	178	64	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 CCDC88C STIM2 ERC1	1.31e-04	180	64	4	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP1 STIM2 SLC4A7 VPS13C	1.33e-04	181	64	4	986c036e656f24fe374807e2711cec9e3c83c892
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GRIP1 GALNTL6 ANK1 GFPT2	1.36e-04	182	64	4	f2a1784ffcba9b27132e0db21e574cbd8a0a6418
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 CCDC88C STIM2 ERC1	1.36e-04	182	64	4	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HLA-DRA GNAI2 DSE FILIP1L	1.36e-04	182	64	4	16186b7a0c33caa48631962381e3ab7e5d166163
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	GRIP1 TMEM67 TIAM2 FILIP1L	1.36e-04	182	64	4	8dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 GALNTL6 PIEZO2 ANK1	1.42e-04	184	64	4	23515c28e1f42aab29cef9e5b4a7f45bda7f5520
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	PIEZO2 SLC16A2 GFPT2 DIAPH3	1.42e-04	184	64	4	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GRIP1 GALNTL6 ANK1 GFPT2	1.45e-04	185	64	4	739260f8abebaf10a5cc49d91726278579e26170
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PARP1 VPS13C TOP2B FILIP1L	1.45e-04	185	64	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 GALNTL6 PIEZO2 ANK1	1.51e-04	187	64	4	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	TMEM67 SLC4A7 CEP112 RNF216	1.51e-04	187	64	4	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	CCDC88C PARP1 STIM2 SLC4A7	1.61e-04	190	64	4	374d8fd63c733178acab07682ed1519693efab45
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	PIEZO2 SLC16A2 RIPOR3 GFPT2	1.61e-04	190	64	4	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 VPS13C TOP2B FILIP1L	1.64e-04	191	64	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B GRIP1 DIAPH3 MYO5C	1.64e-04	191	64	4	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 VPS13C TOP2B FILIP1L	1.64e-04	191	64	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 VPS13C TOP2B FILIP1L	1.64e-04	191	64	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 GALNTL6 SLC4A7 ANK1	1.67e-04	192	64	4	0003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PIEZO2 SLC16A2 GFPT2 RCN3	1.71e-04	193	64	4	b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STIM2 PIEZO2 ERC1 SBF2	1.71e-04	193	64	4	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	CCDC88C PARP1 STIM2 SLC4A7	1.71e-04	193	64	4	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 SLC16A2 GFPT2 RCN3	1.74e-04	194	64	4	48063c9fe3e12aeff0707acada1baa2f8621f093
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRIP1 HLA-DRA DSE FILIP1L	1.74e-04	194	64	4	6af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DRA GNAI2 DSE FILIP1L	1.74e-04	194	64	4	48c37251518f96524807b5bd1bbc2820637666ad
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 SLC16A2 GFPT2 RCN3	1.74e-04	194	64	4	4f31d2cf7eb37b45fefc4da5b41aac0bfdd847b3
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DRA GNAI2 DSE FILIP1L	1.74e-04	194	64	4	7b6a34d1f8922b71dcc931421666c1822cec8345
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRIP1 HLA-DRA DSE FILIP1L	1.74e-04	194	64	4	5c60670ec24470225fabaa6071fdb4ef6e579840
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DRA GNAI2 DSE FILIP1L	1.74e-04	194	64	4	435406ebe626c702f7d5a99a3d68ee85aa09be95
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC88C STIM2 SLC4A7 VPS13C	1.77e-04	195	64	4	4b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 RIPOR3 IRAG1 FILIP1L	1.77e-04	195	64	4	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PARP1 ANK1 HLA-DRA SRSF9	1.77e-04	195	64	4	bf750c516e67c45c6b511909dcff934168a7bbef
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PIEZO2 SLC16A2 RCN3 FILIP1L	1.77e-04	195	64	4	1236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 RIPOR3 IRAG1 FILIP1L	1.77e-04	195	64	4	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC88C PARP1 SLC4A7 VPS13C	1.81e-04	196	64	4	fd756b247b2d8a291e8e71bec6f1e463d6557536
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 RIPOR3 IRAG1 FILIP1L	1.81e-04	196	64	4	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC88C STIM2 SLC4A7 VPS13C	1.81e-04	196	64	4	c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCell	COVID-19_Mild-cDC\|COVID-19_Mild / Disease condition and Cell class	GRIP1 PARP1 HLA-DRA PDCL3	1.84e-04	197	64	4	09045845891de79164124afb6c632e2838906006
ToppCell	Monocytes-cDCs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GRIP1 HLA-DRA DSE FILIP1L	1.84e-04	197	64	4	3388c104af4c6a05988e102627e0c5e34d9dcc45
ToppCell	COVID-19_Mild-cDC-\|COVID-19_Mild / Disease condition and Cell class	GRIP1 PARP1 HLA-DRA PDCL3	1.84e-04	197	64	4	61d6dd023b2ba2bc76f17c06f7c30434ed865171
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-Treg\|ICU-NoSEP / Disease, condition lineage and cell class	TMEM67 SLC4A7 LRRC2 FILIP1L	1.88e-04	198	64	4	1ed4dfe5565328cb0f7ef31e6b2f67dfbdf3e2ac
ToppCell	severe-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GALNTL6 PARP1 HLA-DRA TEX35	1.92e-04	199	64	4	17283d75a2a900369f63ed02996e7ede97f46140
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PIEZO2 SLC16A2 GFPT2 RCN3	1.92e-04	199	64	4	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MRM3 ZZZ3 SLC4A7 SLC16A2	1.95e-04	200	64	4	4db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MRM3 ZZZ3 SLC4A7 SLC16A2	1.95e-04	200	64	4	d46a19274c2836ce7494790ce513764dedcadc79
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	SFPQ VPS13C HLA-DRA GNAI2	1.95e-04	200	64	4	62c25042086f1afd1102e0720e933c2e476468fd
Disease	brain disease (implicated_via_orthology)	STIM2 TIAM2	6.69e-05	6	63	2	DOID:936 (implicated_via_orthology)
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAI2 GNAI3	1.25e-04	8	63	2	DOID:1858 (implicated_via_orthology)
Disease	Ceroid lipofuscinosis, neuronal 1, infantile	PARP1 SIRT1	2.00e-04	10	63	2	C2931673
Disease	Joubert syndrome 1	TMEM67 KATNIP	9.18e-04	21	63	2	C4551568
Disease	executive function measurement	GALNTL6 PIEZO2 KATNIP GFPT2 MYO5C	1.25e-03	376	63	5	EFO_0009332
Disease	HIV Coinfection	SFPQ SRSF9 SIRT1	1.41e-03	103	63	3	C4505456
Disease	HIV Infections	SFPQ SRSF9 SIRT1	1.41e-03	103	63	3	C0019693
Disease	chloride measurement	CLASP1 HLA-DRA	1.76e-03	29	63	2	EFO_0009284
Disease	Familial aplasia of the vermis	TMEM67 KATNIP	1.88e-03	30	63	2	C0431399

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHLVYKMDSEEKQFS	ADAM29	146	Q9UKF5
KSYDFFRHDNEEAMK	PFKFB2	86	O60825
LEVDIDYFMKHSKDH	ANK1	1861	P16157
EKLDAEFDHFVVDMK	CEP112	11	Q8N8E3
ELYKKFEKEFTDHQE	DIAPH3	511	Q9NSV4
KELELYKEDDMESVY	CCDC172	221	P0C7W6
AEKMSEHYKITLEDT	CCDC83	166	Q8IWF9
IFSSDYKRHDDLKEM	AP3B2	31	Q13367
HLMKYVEEEFSEIKE	SLC16A2	341	P36021
EFHDVEDAETYKKML	RCN3	151	Q96D15
VKDYAFVHMEKEADA	RBM14	111	Q96PK6
KLMADNYEDDHFKSS	ERC1	981	Q8IUD2
SKEDAIEHFMKLYEE	PARP1	606	P09874
EELTYLKKSHEEEME	KRT26	216	Q7Z3Y9
FEVKLHDNYELMKDE	KIAA0100	886	Q14667
HDNYELMKDESKESA	KIAA0100	891	Q14667
KQMKIIHEDGYSEDE	GNAI3	51	P08754
DKLPDDHYQEKTAMD	SBF2	701	Q86WG5
EGYAKDMVTDFDEKH	KATNIP	21	O60303
DMVTDFDEKHDEYLI	KATNIP	26	O60303
EHARMKDALDYLKDF	DDX58	556	O95786
KEKLHDVDFYKARME	CCDC88C	336	Q9P219
KRTYEKDHAELMEFK	IRAG1	636	Q9Y6F6
KTYEDMTLEELEDHE	PDCL3	46	Q9H2J4
LMTEKYFKDHVEKDD	KLHL41	226	O60662
DRQHFDKEVMKAYIE	LRRC2	336	Q9BYS8
MKDLLDFADVTYEKH	DSE	856	Q9UL01
VLEEDHYGMEDVKKR	LONP1	486	P36776
YNTHMADEKLEKDEI	CKAP5	1596	Q14008
HGFEEEIMEYKEQIK	FHAD1	916	B1AJZ9
ELMEAFKTLHKEYEQ	IFT81	146	Q8WYA0
YKQDSMDLKVEFETH	GFPT2	71	O94808
ALKEKIHEYMATEDL	FILIP1L	721	Q4L180
LEAKMIKEESDYHDL	ENTR1	306	Q96C92
EAKHDKYMADMDELF	STUB1	201	Q9UNE7
DEVDMAHRFAQEYKK	ADPRS	96	Q9NX46
KDEAIDYHELKVAMR	CETN3	41	O15182
FDGDEIFHVDMAKKE	HLA-DRA	51	P01903
KMYDDAIEAIEKHLI	MAN1A2	421	O60476
ELHKVTLYKDSDMED	GRIP1	1001	Q9Y3R0
EHTKDLDKELDEYMH	PHAX	166	Q9H814
DHVHKEMDYFIKDKL	TMEM67	886	Q5HYA8
FSEREHLKDKLEEYM	GALNTL6	181	Q49A17
KFDYDEDASAMLKEV	ST13P4	206	Q8IZP2
MFLEEHKYFEESFKA	XAB2	526	Q9HCS7
LMTDEIFHDVAYKAK	SLC4A7	491	Q9Y6M7
EDMEYALRKLDDTKF	SRSF9	156	Q13242
TAKEAKEYFADMERH	TOP2B	641	Q02880
QRVMKFHKYEEEEDV	MRM3	311	Q9HC36
KQMKIIHEDGYSEEE	GNAI2	51	P04899
QFHRAMKYDKDEVDL	SIRT1	421	Q96EB6
FDHLIEMDKREGKYD	SBNO2	991	Q9Y2G9
FYEQKIKEMAEHEDF	RNF216	481	Q9NWF9
YDKTALKEAVFDDDM	CLASP1	1276	Q7Z460
KDKLESEMEDAYHEH	SFPQ	516	P23246
EEHYHLTEALKAMEK	TIAM2	1271	Q8IVF5
KMEFHISKVDELYED	RIPOR3	131	Q96MK2
ESDEFIREDMKYKDA	STIM2	91	Q9P246
KKMFHDDELEESEKF	PIEZO2	1886	Q9H5I5
EEHMKIVEEYAKVDL	SLU7	176	O95391
SSLEEIMDKAYDKFD	VPS13C	736	Q709C8
FAQDMKYALEEHEKD	UNC13B	1011	O14795
DYDEKALHELGFKDM	USP34	1291	Q70CQ2
DLAKHDEEDYVEMKE	SUDS3	56	Q9H7L9
LMDKDFDKLHEFVEI	TEX35	76	Q5T0J7
EYPKNKEEDEHFLEM	WDR87	836	Q6ZQQ6
MFLDSRKEDSYIDHK	ZZZ3	251	Q8IYH5
MHYEEIALKSKAEAE	KRT74	316	Q7RTS7
HVFKLEQEEYMKEDI	MYO5C	466	Q9NQX4