Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.77e-105674GO:0052871
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.02e-097674GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.02e-097674GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.39e-0810674GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.39e-0810674GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.39e-0810674GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F2 CYP4F3 CYP4F11

8.09e-0813674GO:0016713
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.17e-0624674GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.92e-0627674GO:0008391
GeneOntologyMolecularFunctionaromatase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.60e-0635674GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F2 CYP4F3 CYP4F11

9.66e-0640674GO:0016709
GeneOntologyMolecularFunction20-hydroxy-leukotriene B4 omega oxidase activity

CYP4F2 CYP4F3

1.11e-052672GO:0097258
GeneOntologyMolecularFunction20-aldehyde-leukotriene B4 20-monooxygenase activity

CYP4F2 CYP4F3

1.11e-052672GO:0097259
GeneOntologyMolecularFunctiontubulin binding

SPIRE2 TTLL4 CAMSAP3 DAG1 CCDC187 SPIRE1 MTCL1 GNAS FAM110C

1.25e-05428679GO:0015631
GeneOntologyMolecularFunctionarachidonate binding

CYP4F8 CYP4F2 CYP4F11

1.60e-0515673GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4F8 CYP4F2 CYP4F11

1.96e-0516673GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F8 CYP4F2 CYP4F11

1.96e-0516673GO:0050543
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.19e-0549674GO:0016712
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4F8 CYP4F2 CYP4F11

1.11e-0428673GO:0036041
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4F8 CYP4F2 KDM4A CYP4F3 CYP4F11

4.87e-04194675GO:0016705
GeneOntologyMolecularFunctionmonooxygenase activity

CYP4F8 CYP4F2 CYP4F3 CYP4F11

6.05e-04115674GO:0004497
GeneOntologyMolecularFunctioncytoskeletal protein binding

SPIRE2 TTLL4 CAMSAP3 DAG1 CCDC187 SPIRE1 MTCL1 GNAS FAM110C MAP3K1 MYBPC2

1.00e-0310996711GO:0008092
GeneOntologyMolecularFunctionfatty acid binding

CYP4F8 CYP4F2 CYP4F11

1.61e-0369673GO:0005504
GeneOntologyMolecularFunctionheme binding

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.79e-03154674GO:0020037
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.25e-03164674GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.35e-03166674GO:0005506
GeneOntologyMolecularFunctionS-adenosyl-L-methionine binding

KMT5C METTL17

2.68e-0323672GO:1904047
GeneOntologyMolecularFunctionmicrotubule binding

SPIRE2 CAMSAP3 CCDC187 SPIRE1 MTCL1

3.74e-03308675GO:0008017
GeneOntologyMolecularFunctionacetyltransferase activity

SRCAP ATAT1 NAA16

5.16e-03104673GO:0016407
GeneOntologyMolecularFunctionmonocarboxylic acid binding

CYP4F8 CYP4F2 CYP4F11

5.59e-03107673GO:0033293
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.26e-096644GO:0036101
GeneOntologyBiologicalProcessleukotriene B4 metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.93e-097644GO:0036102
GeneOntologyBiologicalProcessleukotriene catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.84e-098644GO:0036100
GeneOntologyBiologicalProcessicosanoid catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.74e-0811644GO:1901523
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.09e-0812644GO:0042758
GeneOntologyBiologicalProcessfatty acid derivative catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.91e-0722644GO:1901569
GeneOntologyBiologicalProcessleukotriene metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

7.83e-0641644GO:0006691
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP4F8 CYP4F2 CYP4F11

1.01e-0514643GO:0097267
GeneOntologyBiologicalProcessformin-nucleated actin cable organization

SPIRE2 SPIRE1

2.84e-053642GO:0110009
GeneOntologyBiologicalProcessmenaquinone catabolic process

CYP4F2 CYP4F11

2.84e-053642GO:0042361
GeneOntologyBiologicalProcessformin-nucleated actin cable assembly

SPIRE2 SPIRE1

2.84e-053642GO:0070649
GeneOntologyBiologicalProcessmenaquinone metabolic process

CYP4F2 CYP4F11

5.66e-054642GO:0009233
GeneOntologyBiologicalProcessphylloquinone metabolic process

CYP4F2 CYP4F11

5.66e-054642GO:0042374
GeneOntologyBiologicalProcessphylloquinone catabolic process

CYP4F2 CYP4F11

5.66e-054642GO:0042376
GeneOntologyBiologicalProcessvitamin K catabolic process

CYP4F2 CYP4F11

5.66e-054642GO:0042377
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.91e-0568644GO:0019369
GeneOntologyBiologicalProcessmicrotubule anchoring

CAMSAP3 DAG1 CCDC187

6.24e-0525643GO:0034453
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

7.81e-0573644GO:1901616
GeneOntologyBiologicalProcesspositive regulation of DNA repair

SPIRE2 KMT5C SMCHD1 SPIRE1 INO80D

8.19e-05143645GO:0045739
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.23e-0482644GO:1901568
GeneOntologyBiologicalProcessestablishment of meiotic spindle localization

SPIRE2 SPIRE1

1.41e-046642GO:0051295
GeneOntologyBiologicalProcessprostaglandin catabolic process

CYP4F2 CYP4F11

1.41e-046642GO:1905344
GeneOntologyBiologicalProcessprostanoid catabolic process

CYP4F2 CYP4F11

1.41e-046642GO:0062232
GeneOntologyBiologicalProcesscleavage furrow formation

SPIRE2 SPIRE1

1.97e-047642GO:0036089
GeneOntologyBiologicalProcessparallel actin filament bundle assembly

SPIRE2 SPIRE1

1.97e-047642GO:0030046
GeneOntologyBiologicalProcesspositive regulation of double-strand break repair

SPIRE2 KMT5C SMCHD1 SPIRE1

2.17e-0495644GO:2000781
GeneOntologyBiologicalProcesschromatin organization

KMT5C SMCHD1 MDC1 PER1 FAM47C KDM4A GNAS SRCAP INO80D HDAC7

4.09e-048966410GO:0006325
GeneOntologyBiologicalProcesspolar body extrusion after meiotic divisions

SPIRE2 SPIRE1

4.20e-0410642GO:0040038
GeneOntologyBiologicalProcesschromatin remodeling

KMT5C SMCHD1 PER1 FAM47C KDM4A GNAS SRCAP INO80D HDAC7

4.46e-04741649GO:0006338
GeneOntologyBiologicalProcessfatty acid catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.65e-04116644GO:0009062
GeneOntologyBiologicalProcessactin filament network formation

SPIRE2 SPIRE1

5.12e-0411642GO:0051639
GeneOntologyBiologicalProcessvitamin K metabolic process

CYP4F2 CYP4F11

5.12e-0411642GO:0042373
GeneOntologyBiologicalProcesspositive regulation of DNA metabolic process

SPIRE2 CHTF18 KMT5C SMCHD1 SPIRE1 INO80D

5.78e-04333646GO:0051054
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.98e-04124644GO:0001676
GeneOntologyBiologicalProcessfat-soluble vitamin catabolic process

CYP4F2 CYP4F11

6.13e-0412642GO:0042363
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

6.74e-04128644GO:0033559
GeneOntologyBiologicalProcessmeiotic cytokinesis

SPIRE2 SPIRE1

7.23e-0413642GO:0033206
GeneOntologyBiologicalProcessregulation of DNA repair

SPIRE2 KMT5C SMCHD1 SPIRE1 INO80D

7.96e-04234645GO:0006282
GeneOntologyBiologicalProcessprotein-DNA complex organization

KMT5C SMCHD1 MDC1 PER1 FAM47C KDM4A GNAS SRCAP INO80D HDAC7

9.51e-049996410GO:0071824
GeneOntologyBiologicalProcessicosanoid metabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

9.93e-04142644GO:0006690
GeneOntologyBiologicalProcessmonocarboxylic acid catabolic process

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.07e-03145644GO:0072329
GeneOntologyBiologicalProcessregulation of double-strand break repair

SPIRE2 KMT5C SMCHD1 SPIRE1

1.10e-03146644GO:2000779
GeneOntologyBiologicalProcesspositive regulation of double-strand break repair via nonhomologous end joining

KMT5C SMCHD1

1.25e-0317642GO:2001034
GeneOntologyCellularComponentmicrotubule bundle

MTCL1 ATAT1

1.55e-046682GO:0097427
HumanPhenoHypertrichosis

DPAGT1 LEMD3 SMCHD1 HID1 GNAS SRCAP MAP3K1 KNL1

1.55e-05425168HP:0000998
DomainSpire

SPIRE2 SPIRE1

1.16e-052642IPR029901
DomainCyt_P450_E_grp-I

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.68e-0545644IPR002401
DomainCyt_P450_CS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.24e-0553644IPR017972
DomainKIND

SPIRE2 SPIRE1

3.46e-053642PF16474
DomainCYTOCHROME_P450

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.32e-0557644PS00086
Domain-

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.63e-05586441.10.630.10
Domainp450

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.63e-0558644PF00067
DomainCyt_P450

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.29e-0560644IPR001128
DomainKIND_dom

SPIRE2 SPIRE1

1.15e-045642IPR011019
DomainNUT

NUTM2F NUTM2G

1.15e-045642IPR024310
DomainNUT_N

NUTM2F NUTM2G

1.15e-045642IPR024309
DomainKIND

SPIRE2 SPIRE1

1.15e-045642SM00750
DomainKIND

SPIRE2 SPIRE1

1.15e-045642PS51377
DomainNUT

NUTM2F NUTM2G

1.15e-045642PF12881
DomainZF_C3H1

ZC3H14 ZFC3H1 ZC3H3

1.04e-0358643PS50103
DomainZnf_FYVE_PHD

SPIRE2 PCLO SPIRE1 KDM4A

1.62e-03147644IPR011011
DomainWH2

SPIRE2 SPIRE1

3.04e-0324642PS51082
DomainBRCT

ENGASE MDC1

3.56e-0326642PS50172
DomainBRCT_dom

ENGASE MDC1

4.13e-0328642IPR001357
Domain-

SPIRE2 PIAS3 PCLO SPIRE1 KDM4A MAP3K1

4.32e-034496463.30.40.10
DomainZnf_RING/FYVE/PHD

SPIRE2 PIAS3 PCLO SPIRE1 KDM4A MAP3K1

4.80e-03459646IPR013083
Domain-

PTBP3 ENOX1 LEMD3 PPRC1

9.79e-032446443.30.70.330
PathwayREACTOME_EICOSANOIDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.01e-0812444M27129
PathwayREACTOME_EICOSANOIDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.01e-0812444MM14845
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4F8 CYP4F2 CYP4F3 CYP4F11

8.08e-0814444MM15842
PathwayREACTOME_FATTY_ACIDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.10e-0715444M27126
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.45e-0718444MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.45e-0718444MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.75e-0721444M27137
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F8 CYP4F2 CYP4F3 CYP4F11

9.95e-0725444MM14858
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.16e-0633444MM15918
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.16e-0633444MM15963
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F2 CYP4F3 CYP4F11

6.12e-0612443M27128
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.32e-0559444M27140
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.78e-0561444MM14861
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.04e-0562444M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F8 CYP4F2 CYP4F3 CYP4F11

4.58e-0564444M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F8 CYP4F2 CYP4F3 CYP4F11

5.17e-0566444MM14839
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.02e-04104444M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP4F8 CYP4F2 CYP4F3 CYP4F11

3.14e-04105444MM14842
PathwayWP_TRYPTOPHAN_METABOLISM

CYP4F8 CYP4F2 CYP4F11

4.45e-0448443MM15902
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP4F2 CYP4F11

5.14e-0411442MM14863
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F8 CYP4F2 CYP4F3 CYP4F11

2.12e-1066949068972
Pubmed

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

CYP4F2 CYP4F3 CYP4F11

2.99e-08469318065749
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F8 CYP4F2 CYP4F11

2.99e-08469322665481
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F8 CYP4F2 CYP4F11

2.99e-08469311185557
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ENGASE TNRC18 SPIRE2 TBC1D9B TULP4 PPRC1 KMT5C TTLL4 ADGRB2 PER1 C15orf39 SPIRE1 SRCAP HDAC7

2.99e-081105691435748872
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F8 CYP4F2 CYP4F11

7.45e-08569322969154
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F8 CYP4F2 CYP4F11

7.45e-08569321466787
Pubmed

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

CYP4F8 CYP4F2 CYP4F11

2.60e-07769322160543
Pubmed

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

CYP4F2 CYP4F11

3.88e-06269224138531
Pubmed

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.

CYP4F3 CYP4F11

3.88e-06269215364545
Pubmed

Spire localization via zinc finger-containing domain is crucial for the asymmetric division of mouse oocyte.

SPIRE2 SPIRE1

3.88e-06269230557038
Pubmed

Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.

CYP4F2 CYP4F3

3.88e-0626928026587
Pubmed

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.

SPIRE2 SPIRE1

3.88e-06269227627128
Pubmed

An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.

PCLO PER1

3.88e-06269211285225
Pubmed

Enhanced fear expression in Spir-1 actin organizer mutant mice.

SPIRE2 SPIRE1

3.88e-06269224345451
Pubmed

Expression patterns of the mouse Spir-2 actin nucleator.

SPIRE2 SPIRE1

3.88e-06269220723621
Pubmed

DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].

SPIRE2 SPIRE1

1.16e-05369226287480
Pubmed

Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain.

SPIRE2 SPIRE1

1.16e-05369215053972
Pubmed

Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.

SPIRE2 SPIRE1

1.16e-05369221620703
Pubmed

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

CYP4F2 CYP4F3

1.16e-05369215145985
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.18e-057069415128046
Pubmed

Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.

SPIRE2 SPIRE1

2.32e-05469219605360
Pubmed

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis.

PCLO TRAM2

3.86e-05569212401793
Pubmed

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

CYP4F2 CYP4F3

3.86e-05569218577768
Pubmed

An actin-dependent mechanism for long-range vesicle transport.

SPIRE2 SPIRE1

3.86e-05569221983562
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP4F8 CYP4F2 CYP4F11

9.34e-054469312745259
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

FLT1 TULP4 PER1 MTCL1 TNFRSF10A RREB1

9.63e-0537169615747579
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

CYP4F8 CYP4F2 CYP4F11

1.07e-044669325209997
Pubmed

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.

ZC3H14 ZFC3H1

1.73e-041069227871484
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TNRC18 ESS2 PIAS3 TULP4 MDC1 MAP3K1

2.14e-0443069635044719
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SPIRE2 BMX CAMSAP3 SPIRE1 MTCL1 GNAS ATAT1 HDAC7

3.01e-0486169836931259
Pubmed

Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.

PIAS3 PPP1R15A

3.48e-041469216455055
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

MRPL4 FLT1 TNRC18 SPIRE2 ESS2 LEMD3 MTCL1

4.33e-0468969736543142
Pubmed

Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

RREB1 MAP3K1

4.57e-041669223966867
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

ESS2 LEMD3 DAG1 C15orf39

4.61e-0418069435198878
Pubmed

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.

CYP4F8 CYP4F2 CYP4F11

4.74e-047669322323595
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

FOXR1 TNRC18 ESS2 DAG1 KNL1

5.17e-0433169519490893
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PTBP3 TNRC18 TCERG1L PPRC1 SMCHD1 PCLO CAMSAP3 ZFC3H1 SRCAP MYBPC2

5.33e-041442691035575683
Pubmed

Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development.

FLT1 GNAS

5.81e-041869225977369
Pubmed

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

TTLL4 KDM4A

7.95e-042169222959728
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

TBC1D9B SMCHD1 KDM4A

1.11e-031026939734811
Pubmed

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.

RREB1 PRR18

1.13e-032569232528060
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TNRC18 PCLO C15orf39 RREB1 NUTM2F

1.18e-0339869535016035
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PPRC1 PCLO ZFC3H1

1.21e-031056939628581
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ESS2 SMCHD1 MDC1 KDM4A RREB1 SRCAP

1.31e-0360869636089195
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

LEMD3 MTCL1 GNAS KNL1

1.39e-0324269434011540
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

ZC3H14 TNRC18 ESS2 SMCHD1 C15orf39 RREB1 INO80D KNL1

1.51e-03110369834189442
Pubmed

Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.

PPRC1 HDAC7

1.52e-032969223565059
Pubmed

Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.

FLT1 HDAC7

1.52e-032969224003143
Pubmed

TopBP1 controls BLM protein level to maintain genome stability.

MDC1 ZFC3H1

1.52e-032969224239288
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

CAMSAP3 MTCL1

1.74e-033169228089446
Pubmed

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.

ESS2 LEMD3 MDC1

1.82e-0312169322412018
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

LEMD3 CHTF18 MDC1 ZFC3H1 SRCAP

1.83e-0344069534244565
InteractionPIPSL interactions

KMT5C TTLL4 CAMSAP3 PER1 KDM4A SRCAP ATAT1 ZC3H3

1.85e-06252678int:PIPSL
InteractionTOP3B interactions

ENGASE TNRC18 SPIRE2 TBC1D9B TULP4 PPRC1 KMT5C TTLL4 MDC1 ADGRB2 PER1 C15orf39 SPIRE1 KDM4A GNAS SRCAP HDAC7

4.33e-0614706717int:TOP3B
Cytoband17q25.3

ENGASE B3GNTL1 LINC00482

4.87e-0410169317q25.3
CytobandEnsembl 112 genes in cytogenetic band chr17q25

ENGASE B3GNTL1 LINC00482 HID1

1.20e-03307694chr17q25
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MRPL4 CYP4F8 CAMSAP3 CYP4F2 CYP4F3 CYP4F11

1.27e-03797696chr19p13
Cytoband13q14.11

ENOX1 NAA16

1.59e-033969213q14.11
Cytoband19p13.1

CYP4F8 CYP4F11

2.40e-034869219p13.1
CytobandEnsembl 112 genes in cytogenetic band chr18p11

SMCHD1 SPIRE1 MTCL1

3.96e-03210693chr18p11
GeneFamilyCytochrome P450 family 4

CYP4F8 CYP4F2 CYP4F3 CYP4F11

1.86e-06364541003
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PCLO ZFC3H1

6.23e-041545226
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-plasma_cell-plasma_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHTF18 ADGRB2 C15orf39 ATAT1 TRAM2

5.98e-06166695139bf49eb3624d9eec7e8a2cb33d69716d63a7c5
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-plasma_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHTF18 ADGRB2 C15orf39 ATAT1 TRAM2

5.98e-0616669585f59c3cc7db8863ec0044f1fcc14580834f830b
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHTF18 ADGRB2 C15orf39 ATAT1 TRAM2

6.34e-0616869541da200bbff5c663c39f67c38d6d5f43b0ad9494
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHTF18 ADGRB2 C15orf39 ATAT1 TRAM2

6.34e-06168695a77259c13508f19186d7b0f80b34dc6d89497ab5
ToppCellhealthy_donor-Myeloid-Monocytic-Neutrophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

BMX SMCHD1 CYP4F2 CYP4F3 IRAG1

6.34e-0616869504259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCellCOVID_non-vent-Myeloid-Monocytic-Neutrophil|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

BMX SMCHD1 CYP4F2 CYP4F3 PPP1R15A

1.01e-051856952c89af7cdf5306b900a5b8ec4fdfb8210e5667ed
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENOX1 PCLO MDC1 MTCL1 METTL17

1.04e-05186695f5468e03321ea2083e223eb0d92c3a9307039569
Drugdichloran

CYP4F8 CYP4F2 CYP4F3 CYP4F11

6.78e-0641684CID000007430
Druglansoprazole

CYP4F8 PER1 CYP4F2 CYP4F3 CYP4F11

8.68e-0693685CID000003883
DrugSparteinum

CYP4F8 CYP4F2 CYP4F3 CYP4F11 NAA16

1.30e-05101685CID000003966
Diseasehexadecenedioate (C16:1-DC) measurement

CYP4F2 CYP4F11

1.65e-049642EFO_0800562
Diseasealopecia areata (is_marker_for)

KDM4A HDAC7

2.06e-0410642DOID:986 (is_marker_for)
Diseasebronchopulmonary dysplasia (is_implicated_in)

FLT1 DAG1

3.56e-0413642DOID:11650 (is_implicated_in)
DiseaseDiGeorge Syndrome

ESS2 RREB1

5.45e-0416642C0012236
DiseaseCONOTRUNCAL ANOMALY FACE SYNDROME

ESS2 RREB1

5.45e-0416642C0795907
DiseaseShprintzen syndrome

ESS2 RREB1

5.45e-0416642C0220704
Diseaseperipheral arterial disease, traffic air pollution measurement

CAMSAP3 MTCL1 TRAM2 NUTM2F

8.46e-04194644EFO_0004265, EFO_0007908
Diseasestomach carcinoma (is_marker_for)

MDC1 KDM4A

1.24e-0324642DOID:5517 (is_marker_for)
Diseasewhite matter microstructure measurement

SPIRE2 KMT5C TTLL4 DAG1 IRAG1

1.58e-03390645EFO_0005674
Diseaseconotruncal heart malformations

TULP4 SMCHD1 MAP3K1

1.97e-03114643MONDO_0016581

Protein segments in the cluster

PeptideGeneStartEntry
PPKPRERLTLHRAAA

ADGRB2

1556

O60241
LRVPSPKPRALSRSR

GNAS

561

P84996
GSLPHAPRIKRPRLQ

CHTF18

91

Q8WVB6
PLLPERRKVAESHLP

BTNL10

226

A8MVZ5
LPPRLPALLTATRRA

C9orf50

76

Q5SZB4
SLLGPPPVLRRHHSK

CCDC187

296

A0A096LP49
HRVPTFPDRVLKIPR

BMX

161

P51813
PKHTRPAELRLAPLT

CAMSAP3

781

Q9P1Y5
RRLHRAPSPARPFLK

MTCL1

36

Q9Y4B5
LSRHRPRRTHSKPLP

LEMD3

281

Q9Y2U8
LCLEPPKSRVSHLRP

FAM47C

306

Q5HY64
PRVSSLHLEPPKTRR

FAM47C

781

Q5HY64
LRPPKVLSPGVSHRL

MDC1

101

Q14676
APFSPPKRLRLVVSH

KMT5C

436

Q86Y97
LPKRVRRQIHATPTP

DAG1

306

Q14118
KLRVHRSLPGSAPPL

IRAG1

506

Q9Y6F6
IIPCPRHRIPRLNIK

DPAGT1

296

Q9H3H5
PRIPPDKRIFTTRHT

PER1

351

O15534
RKARHRPHGPLLPTI

PCLO

1756

Q9Y6V0
RPARQDTPPKRHLIT

PDZD7

651

Q9H5P4
QHPKAITPRRLPLTL

NAA16

286

Q6N069
RRQPLSKLPRHHPLV

KDM4A

596

O75164
ERPVRRRHSSILKPP

KNL1

16

Q8NG31
RRHSSILKPPRSPLQ

KNL1

21

Q8NG31
VKPHTPLIRFPDRRD

MRPS36

16

P82909
LLLPAASRPPRKREA

ESS2

11

Q96DF8
KRAQLRSLLPRPPAV

LINC00482

6

Q8N8I6
KESLRLHPPVPVISR

CYP4F11

386

Q9HBI6
KESLRLHPPIPTFAR

CYP4F8

386

P98187
LPSPHKRAPLQSRRL

FOXR1

146

Q6PIV2
KESLRLHPPVPVISR

CYP4F2

386

P78329
LLRSLRLCPPHPTAR

ATAT1

291

Q5SQI0
ARRLPVPRAKIHSLP

COX8A

16

P10176
RQLSHKRPLPLLPSS

INO80D

256

Q53TQ3
KESLRLHPPVPAVSR

CYP4F3

386

Q08477
RHSLRPLRVPPTKLA

ENGASE

536

Q8NFI3
RKIHLRPQVLRPTSP

ESRG

61

Q1W209
LLRKESAPPSLRRRP

HDAC7

176

Q8WUI4
APAPVARRAIARKPL

FAM110C

81

Q1W6H9
HRRKLEEDRLRPPSP

ENOX1

241

Q8TC92
PRITQPVLKRPRHVH

METTL17

386

Q9H7H0
HLEKQLLARPRRPFP

PRR18

151

Q8N4B5
HPARLRKLSFLPTPR

PPRC1

1136

Q5VV67
LQRRLKRPETPTHDP

PPP1R15A

531

O75807
RPPSRELLKHPVFRT

MAP3K1

1496

Q13233
RLKAVRPTSPPQDHR

NUTM2F

586

A1L443
RLKAVRPTSPPQDHR

NUTM2G

571

Q5VZR2
RLLPGHPRRLKVKPD

SMCHD1

921

A6NHR9
PVLRKVELPVPTHRR

MRPL4

46

Q9BYD3
LPAVRPAPREARKSL

NKX1-2

36

Q9UD57
PPTIHKALQRRRRTP

HID1

571

Q8IV36
SRNLRKVPVIPPRIH

PRELP

91

P51888
KLRSTRLRPGSLVPP

SRCAP

3116

Q6ZRS2
DKALPRPIRPHRNIS

TBC1D9B

261

Q66K14
ERPKPRIPILHFRAA

B3GNTL1

311

Q67FW5
IHLVKERLFPRLPPA

C15orf39

846

Q6ZRI6
KRPSRPINITPLARL

PIAS3

236

Q9Y6X2
PRHFLTLAPIKIPLR

TCERG1L

266

Q5VWI1
PSPALLVPSAKRRSR

TNRC18

2291

O15417
ELSRSPRLPLRKPSV

TULP4

561

Q9NRJ4
LCRLPPSRAHLPTKE

ZC3H3

506

Q8IXZ2
LLEPRSKRPAHPILA

RREB1

1661

Q92766
ARKLKPTPPRPRSLH

SPIRE1

356

Q08AE8
RLRPLPPKQRSLHEK

SPIRE2

331

Q8WWL2
QRPRPRVLLKAPTLA

SPIRE2

401

Q8WWL2
VPATPRLPARLIKRE

TRAM2

331

Q15035
DRPPCSPSRVLHLRK

PTBP3

51

O95758
PRPAREASPRLRVHK

TNFRSF10A

76

O00220
TPRPVKLLRGHTLVL

FLT1

236

P17948
PKRRPLLVQRYLHKP

TTLL4

741

Q14679
HVSRRIPVLSPKPAV

ZC3H14

656

Q6PJT7
PKFHRGPRLPRTVIS

ZFC3H1

686

O60293
PRRVKVSHAFLPRVP

INSYN2B

161

A6NMK8
IREIAEPPKIRLPRH

MYBPC2

831

Q14324
EPPKIRLPRHLRQTY

MYBPC2

836

Q14324