Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC6A18 CLCN5 SLC22A1 SLC37A2 SLC25A11 ANO8 XPR1	2.27e-06	171	70	7	GO:0015103
GeneOntologyMolecularFunction	trace-amine receptor activity	TAAR2 TAAR8 TAAR6	2.28e-06	8	70	3	GO:0001594
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC6A18 LRRC8E CLCN5 SLC22A1 LRRC8D ANO8	1.49e-05	151	70	6	GO:0008509
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	HYAL4 AGL HPSE2 FUCA2 MYORG	3.07e-05	103	70	5	GO:0004553
GeneOntologyMolecularFunction	transporter activity	SLC6A18 LRRC8E IGF1R CLCN5 ABCA5 SLC22A1 SLC37A2 SLC25A11 GRIN2D STRA6 ATP1B3 LRRC8D ANO8 XPR1	1.30e-04	1289	70	14	GO:0005215
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	HYAL4 AGL HPSE2 FUCA2 MYORG	1.51e-04	144	70	5	GO:0016798
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A18 LRRC8E CLCN5 ABCA5 SLC22A1 SLC37A2 SLC25A11 GRIN2D STRA6 ATP1B3 LRRC8D ANO8 XPR1	2.04e-04	1180	70	13	GO:0022857
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A18 CLCN5 ABCA5 SLC22A1 SLC37A2 SLC25A11 ATP1B3 XPR1	2.58e-04	477	70	8	GO:0022804
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	TAAR2 TAAR8 TAAR6	4.00e-04	41	70	3	GO:0008227
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	LRRC8E LRRC8D	4.29e-04	9	70	2	GO:0005225
GeneOntologyMolecularFunction	N-acyltransferase activity	TMEM68 SRCAP GTF3C4 CERS4	4.54e-04	102	70	4	GO:0016410
GeneOntologyMolecularFunction	monoatomic anion channel activity	LRRC8E CLCN5 LRRC8D ANO8	4.71e-04	103	70	4	GO:0005253
GeneOntologyMolecularFunction	ATPase binding	PPP3CA DERL1 CAV1 ATP1B3	5.64e-04	108	70	4	GO:0051117
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A18 CLCN5 SLC22A1 SLC37A2 SLC25A11 XPR1	5.97e-04	296	70	6	GO:0015291
GeneOntologyMolecularFunction	RNA polymerase III general transcription initiation factor activity	SNAPC1 GTF3C4	9.22e-04	13	70	2	GO:0000995
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC6A18 CLCN5 SLC22A1 ANO8	9.75e-04	125	70	4	GO:0015108
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A18 CLCN5 SLC22A1 SLC37A2 SLC25A11 GRIN2D ATP1B3 ANO8 XPR1	1.28e-03	758	70	9	GO:0015318
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	TMEM68 SRCAP MBOAT2 GTF3C4 CERS4	1.49e-03	238	70	5	GO:0016747
GeneOntologyMolecularFunction	sodium:chloride symporter activity	SLC6A18 SLC22A1	1.59e-03	17	70	2	GO:0015378
GeneOntologyMolecularFunction	monoatomic anion:sodium symporter activity	SLC6A18 SLC22A1	1.99e-03	19	70	2	GO:0015373
GeneOntologyMolecularFunction	N-acetyltransferase activity	TMEM68 SRCAP GTF3C4	2.60e-03	78	70	3	GO:0008080
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC6A18 SLC22A1	2.92e-03	23	70	2	GO:0015377
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A2 XPR1	3.18e-03	24	70	2	GO:0005315
GeneOntologyMolecularFunction	nuclear steroid receptor activity	PDE3A PAQR7	3.45e-03	25	70	2	GO:0003707
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC6A18 SLC22A1	3.73e-03	26	70	2	GO:0015296
GeneOntologyMolecularFunction	cytokine receptor activity	IFNGR2 EBI3 CCR1	4.81e-03	97	70	3	GO:0004896
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK3 CDK5	4.95e-03	30	70	2	GO:0004693
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK3 CDK5	4.95e-03	30	70	2	GO:0097472
GeneOntologyMolecularFunction	lipid transporter activity	ABCA5 SLC22A1 STRA6 ANO8	4.98e-03	196	70	4	GO:0005319
GeneOntologyMolecularFunction	alcohol binding	CAV1 STRA6 XPR1	5.53e-03	102	70	3	GO:0043178
GeneOntologyMolecularFunction	acyltransferase activity	BARD1 TRIM34 TMEM68 TRIM13 SRCAP MBOAT2 GTF3C4 CERS4	5.61e-03	775	70	8	GO:0016746
GeneOntologyMolecularFunction	acylglycerol O-acyltransferase activity	TMEM68 MBOAT2	5.61e-03	32	70	2	GO:0016411
GeneOntologyMolecularFunction	hormone binding	GIPR PDE3A IGF1R	5.68e-03	103	70	3	GO:0042562
GeneOntologyMolecularFunction	acetyltransferase activity	TMEM68 SRCAP GTF3C4	5.83e-03	104	70	3	GO:0016407
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A18 LRRC8E CLCN5 SLC22A1 GRIN2D ATP1B3 LRRC8D ANO8	6.42e-03	793	70	8	GO:0015075
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC22A1 STRA6	7.07e-03	36	70	2	GO:0090482
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	IFNGR2 GIPR IGF1R GPR27 EBI3 PTCH2 TAAR2 CCR1 GRIN2D TAAR8 TAAR6	7.14e-03	1353	70	11	GO:0004888
GeneOntologyBiologicalProcess	phosphate ion transmembrane transport	SLC37A2 SLC25A11 XPR1	1.58e-05	15	69	3	GO:0035435
GeneOntologyCellularComponent	endoplasmic reticulum membrane	UGT1A4 LRRC8E IFNGR2 NBAS FAF2 DERL1 PSENEN SLC37A2 CAV1 GRIN2D TMEM68 TRIM13 LRRC8D MBOAT2 CERS4 GGCX MYORG	8.81e-07	1293	70	17	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	UGT1A4 LRRC8E IFNGR2 NBAS FAF2 DERL1 PSENEN SLC37A2 CAV1 GRIN2D TMEM68 TRIM13 LRRC8D MBOAT2 CERS4 GGCX MYORG	9.39e-07	1299	70	17	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	UGT1A4 LRRC8E IFNGR2 NBAS FAF2 DERL1 PSENEN SLC37A2 CAV1 GRIN2D TMEM68 TRIM13 LRRC8D MBOAT2 CERS4 GGCX MYORG	1.26e-06	1327	70	17	GO:0042175
Domain	Glycoside_hydrolase_SF	HYAL4 AGL HPSE2 FUCA2 MYORG	1.49e-06	53	69	5	IPR017853
Domain	TAAR_fam	TAAR2 TAAR8 TAAR6	1.67e-06	7	69	3	IPR009132
Domain	LRRC8_Pannexin-like	LRRC8E LRRC8D	1.34e-04	5	69	2	IPR021040
Domain	Pannexin_like	LRRC8E LRRC8D	1.34e-04	5	69	2	PF12534
Domain	-	AGL HPSE2 FUCA2	2.90e-04	35	69	3	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	AGL HPSE2 FUCA2	3.71e-04	38	69	3	IPR013781
Domain	7TM_GPCR_Srsx	TAAR2 CCR1 TAAR8 TAAR6	7.85e-04	112	69	4	SM01381
Domain	fn3	IFNGR2 IGF1R EBI3 OBSCN	3.04e-03	162	69	4	PF00041
Domain	Znf_RING_CS	BMI1 BARD1 TRIM34 TRIM13	3.11e-03	163	69	4	IPR017907
Domain	FN3	IFNGR2 IGF1R EBI3 OBSCN	4.88e-03	185	69	4	SM00060
Domain	PROTEIN_KINASE_TYR	IGF1R OBSCN LMTK3	5.55e-03	97	69	3	PS00109
Domain	FN3	IFNGR2 IGF1R EBI3 OBSCN	6.30e-03	199	69	4	PS50853
Domain	PROTEIN_KINASE_ATP	MAP2K4 IGF1R OBSCN LMTK3 CDK3 CDK5	6.93e-03	459	69	6	PS00107
Domain	FN3_dom	IFNGR2 IGF1R EBI3 OBSCN	7.47e-03	209	69	4	IPR003961
Domain	PROTEIN_KINASE_DOM	MAP2K4 IGF1R OBSCN LMTK3 CDK3 CDK5	9.67e-03	493	69	6	PS50011
Domain	-	HYAL4 MYORG	1.05e-02	42	69	2	3.20.20.70
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	GIPR PDE3A GPR27 TAAR2 TAAR8 TAAR6	3.44e-05	143	61	6	MM15055
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	GIPR PDE3A GPR27 TAAR2 TAAR8 TAAR6	5.81e-05	157	61	6	M4904
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	NBAS FAF2 DERL1 CLPTM1 UGGT2 TRIM13 LRRC8D MBOAT2 CERS4 GGCX ANO8	2.47e-09	468	70	11	31056421
Pubmed	Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.	TAAR2 TAAR8 TAAR6	6.50e-07	9	70	3	15718104
Pubmed	Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.	IGF1R FAF2 DERL1	6.50e-07	9	70	3	26692333
Pubmed	A second class of chemosensory receptors in the olfactory epithelium.	TAAR2 TAAR8 TAAR6	6.50e-07	9	70	3	16878137
Pubmed	Expression of trace amine-associated receptors in the Grueneberg ganglion.	TAAR2 TAAR8 TAAR6	9.28e-07	10	70	3	17556730
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	UGT1A4 SLC6A18 IFNGR2 IGF1R ABCA5 BARD1 CAV1 CDK5	2.11e-06	421	70	8	19692168
Pubmed	IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance.	BMI1 IGF1R	3.99e-06	2	70	2	23990442
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	FAF2 DERL1 CLPTM1 SLC25A11 CAV1 TMEM181 GGCX CDK5	7.35e-06	499	70	8	22810586
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SCCPDH FAF2 RNPEP FPGS PPA2 UGGT2 TSPAN14 CAV1 STRA6 TMEM68 LRRC8D	8.44e-06	1061	70	11	33845483
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	NBAS MAP2K4 SCCPDH FAF2 FPGS CLPTM1 FUCA2 GGCX CDK5	9.54e-06	686	70	9	28380382
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	UGT1A4 IFNGR2 IGF1R ABCA5 BARD1 CAV1 CDK5	1.05e-05	374	70	7	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	UGT1A4 IFNGR2 IGF1R ABCA5 BARD1 CAV1 CDK5	1.19e-05	381	70	7	18676680
Pubmed	Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.	FPGS GGCX	1.20e-05	3	70	2	26751406
Pubmed	Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.	IGF1R CAV1	1.20e-05	3	70	2	26138883
Pubmed	Activation of β1 integrins and caveolin-1 by TF/FVIIa promotes IGF-1R signaling and cell survival.	IGF1R CAV1	1.20e-05	3	70	2	32458278
Pubmed	IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells.	IGF1R CAV1	1.20e-05	3	70	2	21152401
Pubmed	Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling.	IGF1R CAV1	1.20e-05	3	70	2	23404184
Pubmed	Caveolin-1 increases glycolysis in pancreatic cancer cells and triggers cachectic states.	IGF1R CAV1	1.20e-05	3	70	2	34320244
Pubmed	IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.	IGF1R CAV1	1.20e-05	3	70	2	21611203
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	UGT1A4 IFNGR2 IGF1R ABCA5 BARD1 CAV1 CDK5	1.21e-05	382	70	7	19170196
Pubmed	LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.	LRRC8E LRRC8D	2.39e-05	4	70	2	26824658
Pubmed	Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways.	IGF1R CAV1	2.39e-05	4	70	2	17014845
Pubmed	VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.	BMI1 IGF1R	2.39e-05	4	70	2	22777769
Pubmed	Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1.	IGF1R CAV1	2.39e-05	4	70	2	23472139
Pubmed	The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.	DERL1 TRIM13	2.39e-05	4	70	2	21186355
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8E LRRC8D	2.39e-05	4	70	2	28193731
Pubmed	LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.	LRRC8E LRRC8D	2.39e-05	4	70	2	33171122
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	SCCPDH CLPTM1 LEPROTL1 ABHD13 TSPAN14 FUCA2 MBOAT2	2.58e-05	430	70	7	16303743
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	IGF1R CLPTM1 UGGT2 FUCA2 CAV1 TRIM13 ATP1B3 LRRC8D MBOAT2 GGCX MYORG	2.66e-05	1201	70	11	35696571
Pubmed	Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum.	FAF2 DERL1	3.98e-05	5	70	2	21909096
Pubmed	Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.	CDK3 CDK5	3.98e-05	5	70	2	10896159
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8E LRRC8D	3.98e-05	5	70	2	35777784
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8E LRRC8D	3.98e-05	5	70	2	15094057
Pubmed	Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets.	FAF2 DERL1	3.98e-05	5	70	2	22238364
Pubmed	Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.	PPP3CA CDK5	3.98e-05	5	70	2	14704270
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8E LRRC8D	3.98e-05	5	70	2	24790029
Pubmed	Trace amines: identification of a family of mammalian G protein-coupled receptors.	TAAR8 TAAR6	3.98e-05	5	70	2	11459929
Pubmed	ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.	CDK3 CDK5	3.98e-05	5	70	2	11955625
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	GIPR TAAR2 CCR1 TAAR8 TAAR6	5.35e-05	200	70	5	18240029
Pubmed	Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.	IGF1R PPP3CA	5.96e-05	6	70	2	20153290
Pubmed	Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.	FAF2 DERL1	5.96e-05	6	70	2	24160817
Pubmed	Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.	IGF1R GRB14	5.96e-05	6	70	2	23190452
Pubmed	Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.	IGF1R CAV1	5.96e-05	6	70	2	18286479
Pubmed	Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.	DERL1 CAV1	5.96e-05	6	70	2	24089527
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	UGT1A4 IFNGR2 IGF1R FPGS BARD1 CDK5	7.71e-05	351	70	6	20453000
Pubmed	A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.	FAF2 DERL1	8.33e-05	7	70	2	23665563
Pubmed	Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice.	GIPR PAQR7	8.33e-05	7	70	2	22933106
Pubmed	The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.	FAF2 DERL1	8.33e-05	7	70	2	19818707
Pubmed	Interaction between Cdc37 and Cdk4 in human cells.	CDK3 CDK5	8.33e-05	7	70	2	9150368
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	FAF2 DERL1 ATP1B3	8.47e-05	42	70	3	32738194
Pubmed	A family of human cdc2-related protein kinases.	CDK3 CDK5	1.11e-04	8	70	2	1639063
Pubmed	BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.	BMI1 BARD1	1.11e-04	8	70	2	33589814
Pubmed	Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.	CDK3 CDK5	1.11e-04	8	70	2	22654103
Pubmed	ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).	CDK3 CDK5	1.11e-04	8	70	2	11733001
Pubmed	Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.	FAF2 DERL1	1.11e-04	8	70	2	24356957
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	FAF2 DERL1 CLPTM1 ABHD13 TRIM13	1.14e-04	235	70	5	32614325
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LRRC8E IGF1R SCCPDH FAF2 DERL1 CLPTM1 CAV1 ATP1B3 GTF3C4 GGCX	1.42e-04	1203	70	10	29180619
Pubmed	The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.	FAF2 DERL1	1.42e-04	9	70	2	20435896
Pubmed	Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.	CDK3 CDK5	1.42e-04	9	70	2	9438340
Pubmed	Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.	HPSE2 XPR1	1.42e-04	9	70	2	23829686
Pubmed	Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.	FAF2 DERL1	1.42e-04	9	70	2	34739333
Pubmed	Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.	SLC22A1 CLPTM1 SLC25A11	1.43e-04	50	70	3	31318583
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	IGF1R FAF2 UGGT2 SLC25A11 FUCA2 GGCX MYORG	2.34e-04	613	70	7	22268729
Pubmed	Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses.	FAF2 DERL1 AGL	2.46e-04	60	70	3	36590901
Pubmed	Single nuclei RNA-seq of mouse placental labyrinth development.	IGF1R STRA6	2.60e-04	12	70	2	33141023
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8E LRRC8D	2.60e-04	12	70	2	32277911
Pubmed	Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.	NBAS PDE3A	3.07e-04	13	70	2	21844884
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	FAF2 DERL1 CLPTM1 SLC25A11 CAV1 ATP1B3 GGCX	3.56e-04	657	70	7	36180527
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	LMTK3 SRCAP	3.58e-04	14	70	2	28263302
Pubmed	Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.	GPR27 LMTK3	4.71e-04	16	70	2	25113059
Pubmed	AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.	FAF2 DERL1 CAV1	4.94e-04	76	70	3	29599191
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	PPP3CA GRIN2D	5.33e-04	17	70	2	24086760
Pubmed	Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.	SCCPDH FAF2	5.33e-04	17	70	2	14741744
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM34 TRIM13	5.98e-04	18	70	2	23077300
Pubmed	VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.	BMI1 PTCH2	5.98e-04	18	70	2	31068622
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	LRRC8E FAF2 CLPTM1 SLC25A11 CAV1 ATP1B3 MBOAT2 CDK5	6.45e-04	952	70	8	38569033
Pubmed	Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK).	FAF2 DERL1	6.68e-04	19	70	2	25660456
Pubmed	The Role of CDKs and CDKIs in Murine Development.	CDK3 CDK5	8.18e-04	21	70	2	32731332
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC6A18 CLCN5 SLC22A1 SLC37A2	8.98e-04	212	70	4	19521566
Pubmed	HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.	IFNGR2 IGF1R	8.99e-04	22	70	2	15103018
Pubmed	Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.	MBTD1 SRCAP	9.83e-04	23	70	2	14966270
Pubmed	Large-scale concatenation cDNA sequencing.	DERL1 SLC25A11 CAV1 LRRC8D MBOAT2 XPR1	1.00e-03	568	70	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	DERL1 SLC25A11 CAV1 LRRC8D MBOAT2 XPR1	1.06e-03	574	70	6	8619474
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN ANO8 EPG5	1.13e-03	101	70	3	10997877
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NBAS FAF2 PPA2 SLC25A11 SRCAP GTF3C4 EPG5	1.19e-03	807	70	7	30575818
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	SCCPDH PPP3CA AGL CAV1	1.21e-03	230	70	4	35449600
Pubmed	TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.	FAF2 DERL1	1.26e-03	26	70	2	35961308
Pubmed	Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.	MAP2K4 CDK5	1.26e-03	26	70	2	17875933
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	PDE3A SCCPDH FAF2 CAV1 GTF3C4	1.27e-03	399	70	5	37536630
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FAF2 DERL1 CLPTM1 CAV1 ATP1B3	1.40e-03	408	70	5	33766124
Pubmed	The DNA sequence and analysis of human chromosome 6.	MEI4 TAAR2 FUCA2 TAAR8 TMEM181 TAAR6	1.59e-03	622	70	6	14574404
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	FAF2 RNPEP AGL SLC25A11 CAV1	1.63e-03	422	70	5	27342126
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E IGF1R PPA2 OBSCN GRIN2D SRCAP MYORG ANO8	1.67e-03	1105	70	8	35748872
Pubmed	Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.	GRIN2D CDK5	1.67e-03	30	70	2	18603407
Pubmed	Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells.	PDE3A FAF2 SLC25A11	1.85e-03	120	70	3	31298480
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	NBAS AGL SRCAP	1.85e-03	120	70	3	21697133
Interaction	OTULINL interactions	NBAS FAF2 DERL1 CLPTM1 TRIM13 LRRC8D MBOAT2 CERS4 GGCX ANO8	7.44e-07	405	66	10	int:OTULINL
Interaction	LNPK interactions	NBAS FAF2 DERL1 AGL TRIM13 ATP1B3 MBOAT2 ANO8	2.02e-05	355	66	8	int:LNPK
Cytoband	6q24	TAAR2 FUCA2	6.38e-05	8	70	2	6q24
Cytoband	6q23.2	TAAR8 TAAR6	6.72e-04	25	70	2	6q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr6q23	TAAR2 TAAR8 TAAR6	8.19e-04	119	70	3	chr6q23
Cytoband	6q25.3	SLC22A1 TMEM181	1.17e-03	33	70	2	6q25.3
GeneFamily	Trace amine receptors	TAAR2 TAAR8 TAAR6	1.46e-06	9	48	3	188
GeneFamily	Volume regulated anion channel subunits	LRRC8E LRRC8D	6.87e-05	5	48	2	1158
GeneFamily	Fibronectin type III domain containing	IFNGR2 IGF1R EBI3 OBSCN	8.49e-04	160	48	4	555
GeneFamily	Cyclin dependent kinases	CDK3 CDK5	2.15e-03	26	48	2	496
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	IGF1R LMTK3	5.05e-03	40	48	2	321
Disease	Fahr's syndrome (disorder)	MYORG XPR1	5.21e-05	5	68	2	C0393590
Disease	basal ganglia calcification (is_implicated_in)	MYORG XPR1	7.80e-05	6	68	2	DOID:0060230 (is_implicated_in)
Disease	Lewy body dementia (is_marker_for)	IGF1R CCR1	8.72e-04	19	68	2	DOID:12217 (is_marker_for)
Disease	tissue factor measurement	UGT1A4 MEI4	1.07e-03	21	68	2	EFO_0010623
Disease	Immunologic Deficiency Syndromes	NBAS EPG5	1.28e-03	23	68	2	C0021051
Disease	breast cancer (implicated_via_orthology)	BARD1 CAV1	1.52e-03	25	68	2	DOID:1612 (implicated_via_orthology)
Disease	metabolite measurement	UGT1A4 NBAS RNPEP SLC22A1 TMEM68 CERS4	1.84e-03	560	68	6	EFO_0004725
Disease	Drug-Induced Stevens Johnson Syndrome	DERL1 CAV1	2.04e-03	29	68	2	C1274933
Disease	Toxic Epidermal Necrolysis	DERL1 CAV1	2.04e-03	29	68	2	C0014518
Disease	Mycoplasma-Induced Stevens-Johnson Syndrome	DERL1 CAV1	2.04e-03	29	68	2	C3658301
Disease	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	DERL1 CAV1	2.04e-03	29	68	2	C3658302
Disease	Stevens-Johnson Syndrome	DERL1 CAV1	2.18e-03	30	68	2	C0038325

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLRRSSLYFLKPSYW	ABCA5	426	Q8WWZ7
RYLPLWCYKNKFLSY	ABHD13	236	Q7L211
FILYAFHSTYRKLPW	EPG5	2046	Q9HCE0
KPSLYWWYLLELGFY	CERS4	176	Q9HA82
KLFGPYVWGRYDLLF	RNPEP	276	Q9H4A4
QLLPKLFDGCYFYLW	BARD1	666	Q99728
GKLFWVFFLIPYLDI	BTLA	11	Q7Z6A9
WYRPPDVLFGAKLYS	CDK5	166	Q00535
FRYYLLLGWGAPALF	GIPR	256	P48546
KYWFYRLLSALFGIP	CAV1	96	Q03135
RAEEFYYPPWKRLLF	ANO8	341	Q9HCE9
YYPPWKRLLFQLLVS	ANO8	346	Q9HCE9
TLYELATGRFPYPKW	MAP2K4	296	P45985
FRKQPFLWRAALLYY	KIAA0895L	326	Q68EN5
LFWKPYIYAGYRPLH	PAQR7	41	Q86WK9
LLAARPKYYFAWTLA	MBOAT2	281	Q6ZWT7
PRGYTKLPFKWFDYL	MBTD1	456	Q05BQ5
LARPRLKLPYADYWY	LMTK3	371	Q96Q04
YIYTWRRNGPLPLKY	BMI1	211	P35226
IRGWKLFYNYALVIF	IGF1R	106	P08069
FYAVTLLFLLLWGPY	GPR27	286	Q9NS67
RFKVAWRPYLAYLAG	PDE3A	231	Q14432
PAYLFLWPEAFLYRF	DERL1	36	Q9BUN8
ALPIYNKYWPLFVLF	LEPROTL1	26	O95214
NKYWPLFVLFFYILS	LEPROTL1	31	O95214
LYWLFHRPLKEYSFR	LRRC8E	331	Q6NSJ5
FNPLPDYWLSLLYKR	HPSE2	436	Q8WWQ2
LFLRQYIWYSPAPFL	NBAS	61	A2RRP1
RKYYLGGFAFLPFLW	PSENEN	16	Q9NZ42
FSLWKGFTPYYARLG	SLC25A11	276	Q02978
QLKVKGYPAPRLYWF	OBSCN	5281	Q5VST9
LWYRAPEILLGSKFY	CDK3	166	Q00526
RFGLYYSLFEWFHPL	FUCA2	176	Q9BTY2
FAKLVSYTFLYWLPL	SLC37A2	306	Q8TED4
LLFLFTLPFWIDYKL	CCR1	81	P32246
YYFPLKTLWRSFFAA	CLCN5	341	P51795
GIKSRPKGLWGYYLY	HYAL4	206	Q2M3T9
PFPEIFSLKYWIRYK	EBI3	156	Q14213
CFFLVLKYRGLIKYW	IFNGR2	266	P38484
PISPELFTKYFWRLY	FPGS	146	Q05932
WKKIYFFLRRSGLYF	GRB14	251	Q14449
LAVSLPTFLFLLYYW	SLC22A1	266	O15245
LYLWALKILYPKTLF	PPP3CA	131	Q08209
LYTLFWLFRIPLKEY	LRRC8D	381	Q7L1W4
FPLFTFYLWRVGILL	MEI4	361	A8MW99
NLYTKYRPLFGYWVI	TRIM34	386	Q9BYJ4
YALFYPWFRKAIKVI	TAAR6	311	Q96RI8
NPLIYALFYPWFRKA	TAAR8	306	Q969N4
RQLLIKFPWFFSFGY	SCCPDH	306	Q8NBX0
KAPLWLRAYFQGLLF	PTCH2	31	Q9Y6C5
LLGWGYYLIMLPFRF	FAF2	91	Q96CS3
LFLVLGFLYYSAWKL	ST3GAL3	16	Q11203
LWLGPFFYYLPKAVL	SLC26A10	366	Q8NG04
LRYVANIFPYKGYIW	PPA2	126	Q9H2U2
LKRWCPSFKILTYYG	SRCAP	686	Q6ZRS2
APRGAWKILGLFYYA	STRA6	141	Q9BX79
FVAYIILLFWKPLRY	SLC6A18	531	Q96N87
KEALALAWRYFLPPY	SNAPC1	56	Q16533
WGLILLFYLVFYGFL	ATP1B3	36	P54709
FRYLSWILFPLLGCY	CLPTM1	476	O96005
FYYKSRFWLLKLLFR	XPR1	366	Q9UBH6
LFLLPYWYVFLLDKT	GGCX	141	P38435
FISKIPWSFYKLFLL	TRIM13	306	O60858
LFRWLYEKFRYPFAP	TMEM68	251	Q96MH6
LTFYLPKFFIVGLLW	TMEM181	411	Q9P2C4
KTRWLYGFIRFLLYF	TMEM250	46	H0YL14
GFFYPWFRRALKYIL	TAAR2	316	Q9P1P5
TYFWRFKLFLLRILY	GTF3C4	571	Q9UKN8
KYLLFSYNIIFWLAG	TSPAN14	16	Q8NG11
WGYKILFLDVLFPLA	UGGT2	1311	Q9NYU1
LAKYLSIPAVFFWRY	UGT1A4	161	P22310
WLWPIGYFLRAKLYF	AGL	1451	P35573
YLPAGKWRSYKGELF	MYORG	676	Q6NSJ0
LKYPLWSRYGRFLQP	GRIN2D	411	O15399