Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	general transcription initiation factor binding	TAF1L CREBBP NACA	4.32e-04	64	46	3	GO:0140296
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	CCAR2 TAF1L CREBBP	4.73e-04	66	46	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	CCAR2 TAF1L CREBBP	4.73e-04	66	46	3	GO:0001098
MousePheno	increased grooming behavior	KMT2D POGZ SHANK2 CREBBP	2.04e-05	74	31	4	MP:0001441
MousePheno	abnormal prenatal growth/weight/body size	PIKFYVE LRP2 ELOA POGZ IFT52 CREBBP AHDC1 NOS3 CRB2 NACA RSF1 PARVA	4.27e-05	1493	31	12	MP:0004196
MousePheno	decreased vascular endothelial cell number	CREBBP NOS3	1.32e-04	8	31	2	MP:0006057
MousePheno	abnormal heart septum morphology	LRP2 POGZ CREBBP NOS3 NACA PARVA	1.80e-04	388	31	6	MP:0006113
MousePheno	abnormal grooming behavior	KMT2D POGZ SHANK2 CREBBP	2.26e-04	137	31	4	MP:0001440
MousePheno	prenatal lethality prior to heart atrial septation, incomplete penetrance	PIKFYVE POGZ CREBBP ELMO2 NACA PARVA	2.42e-04	410	31	6	MP:0031660
MousePheno	embryonic lethality, incomplete penetrance	PIKFYVE POGZ CREBBP ELMO2 NACA PARVA	2.42e-04	410	31	6	MP:0011102
MousePheno	abnormal heart ventricle morphology	PIKFYVE LRP2 ELOA POGZ CREBBP NOS3 FAT3 NACA	2.54e-04	793	31	8	MP:0005294
MousePheno	flattened snout	KMT2D CREBBP	3.10e-04	12	31	2	MP:0000447
Domain	EGF_Ca-bd_CS	LRP2 FAT3 CRB2	1.65e-03	97	45	3	IPR018097
Domain	EGF_CA	LRP2 FAT3 CRB2	1.74e-03	99	45	3	PS01187
Domain	Bromodomain_CS	TAF1L CREBBP	1.78e-03	26	45	2	IPR018359
Domain	ASX_HYDROXYL	LRP2 FAT3 CRB2	1.80e-03	100	45	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 FAT3 CRB2	2.12e-03	106	45	3	IPR000152
Domain	EGF_CA	LRP2 FAT3 CRB2	3.16e-03	122	45	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 FAT3 CRB2	3.31e-03	124	45	3	IPR001881
Domain	BROMODOMAIN_1	TAF1L CREBBP	3.58e-03	37	45	2	PS00633
Domain	Bromodomain	TAF1L CREBBP	3.78e-03	38	45	2	PF00439
Domain	LAM_G_DOMAIN	FAT3 CRB2	3.78e-03	38	45	2	PS50025
Domain	Laminin_G_2	FAT3 CRB2	4.18e-03	40	45	2	PF02210
Domain	SET	KMT2D PRDM11	4.38e-03	41	45	2	PF00856
Domain	BROMODOMAIN_2	TAF1L CREBBP	4.38e-03	41	45	2	PS50014
Domain	BROMO	TAF1L CREBBP	4.60e-03	42	45	2	SM00297
Domain	Bromodomain	TAF1L CREBBP	4.60e-03	42	45	2	IPR001487
Domain	-	TAF1L CREBBP	4.60e-03	42	45	2	1.20.920.10
Domain	LamG	FAT3 CRB2	5.04e-03	44	45	2	SM00282
Domain	Znf_FYVE_PHD	PIKFYVE KMT2D RSF1	5.32e-03	147	45	3	IPR011011
Domain	SET	KMT2D PRDM11	5.49e-03	46	45	2	SM00317
Domain	SET_dom	KMT2D PRDM11	6.46e-03	50	45	2	IPR001214
Domain	SET	KMT2D PRDM11	6.46e-03	50	45	2	PS50280
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	NOS3 AOX1	1.47e-04	8	33	2	M39677
Pathway	PID_ILK_PATHWAY	ELMO2 NACA PARVA	1.55e-04	45	33	3	M71
Pubmed	A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.	KMT2D CREBBP	1.71e-06	2	46	2	27999180
Pubmed	Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.	KMT2D CREBBP	5.13e-06	3	46	2	34463256
Pubmed	KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.	KMT2D CREBBP	5.13e-06	3	46	2	36893259
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PPIL4 CCAR2 BOP1 POGZ SBF1 AUP1 CREBBP PPM1F NACA RSF1	8.71e-06	1353	46	10	29467282
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2D CREBBP	1.03e-05	4	46	2	28398509
Pubmed	DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination.	CCAR2 CREBBP	1.03e-05	4	46	2	30893604
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE KMT2D ITPRIPL2 SHANK2 SBF1 AHDC1 ANKRD9 WNK2 BAHCC1	1.22e-05	1105	46	9	35748872
Pubmed	Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.	KMT2D CREBBP	2.56e-05	6	46	2	38570506
Pubmed	Congenital Diaphragmatic Hernia Overview	LRP2 KMT2D POGZ	3.16e-05	46	46	3	20301533
Pubmed	iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium.	NOS3 PARVA	3.58e-05	7	46	2	28546219
Pubmed	A human MAP kinase interactome.	GIGYF2 NCKAP5 POGZ KIAA1549L CREBBP WNK2	4.21e-05	486	46	6	20936779
Pubmed	Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development.	GIGYF2 FAT3	4.77e-05	8	46	2	39117691
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2D TAF1L CREBBP	6.03e-05	57	46	3	18022353
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	CDCA3 SBF1 ELMO2 PPM1F	6.06e-05	160	46	4	31678930
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BOP1 POGZ SBF1 PPM1F WNK2 NACA	6.73e-05	529	46	6	14621295
Pubmed	Human transcription factor protein interaction networks.	PPIL4 LRP2 GIGYF2 CCAR2 KMT2D POGZ TAF1L CREBBP NACA	9.07e-05	1429	46	9	35140242
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LRP2 ZNF469 POGZ CREBBP FAT3 AOX1 BAHCC1 RSF1	9.68e-05	1116	46	8	31753913
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2D POGZ CREBBP AHDC1 BAHCC1	9.93e-05	351	46	5	38297188
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2D CREBBP	1.12e-04	12	46	2	17707229
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP2 ARHGAP9 RSF1	1.16e-04	71	46	3	33541421
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2D CREBBP	1.54e-04	14	46	2	12482968
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	GIGYF2 AUP1 PPM1F PARVA	1.79e-04	212	46	4	33462405
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	PIKFYVE GIGYF2 NACA PARVA	1.92e-04	216	46	4	31519766
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	PPIL4 CCAR2 ZNF469 AUP1 NACA RSF1	2.12e-04	653	46	6	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GIGYF2 CCAR2 BOP1 POGZ SBF1 RSF1	2.12e-04	653	46	6	22586326
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PPIL4 ELOA POGZ CREBBP	2.14e-04	222	46	4	37071664
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	LRP2 GIGYF2 KMT2D POGZ PPM1F	2.24e-04	418	46	5	34709266
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GIGYF2 KMT2D KIAA1549L FAT3	2.61e-04	234	46	4	36243803
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	PPIL4 CCAR2 BOP1 NACA RSF1	2.86e-04	441	46	5	31239290
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	GIGYF2 KMT2D	4.25e-04	23	46	2	9225980
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GIGYF2 TJAP1 ELOA CCAR2 KMT2D POGZ	5.23e-04	774	46	6	15302935
Pubmed	Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.	MPP4 CRB2	5.88e-04	27	46	2	23001562
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	CCAR2 CREBBP	9.35e-04	34	46	2	30894540
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	LRP2 NCKAP5 SHANK2 WNK2	9.38e-04	329	46	4	17474147
Pubmed	Functional proteomics mapping of a human signaling pathway.	PPIL4 ARHGAP9 KMT2D AUP1 CREBBP	1.07e-03	591	46	5	15231748
Pubmed	DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.	ELOA BOP1	1.23e-03	39	46	2	25825154
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	PRDM11 HUNK BCDIN3D AHDC1 NOS3 ZXDB	1.25e-03	915	46	6	32393512
Cytoband	12q13.12	KMT2D BCDIN3D	6.75e-04	38	46	2	12q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	ARHGAP9 KMT2D BCDIN3D NACA	8.54e-04	423	46	4	chr12q13
GeneFamily	Ataxins\|Trinucleotide repeat containing	GIGYF2 KMT2D	6.31e-04	25	27	2	775
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP2 NCKAP5 FBXO17 SHANK2 AOX1	1.16e-06	180	46	5	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP2 NCKAP5 FBXO17 SHANK2 AOX1	1.16e-06	180	46	5	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	NCKAP5 SHANK2 ALS2CL PARVA	3.11e-05	174	46	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NCKAP5 ALS2CL ANKRD9 PARVA	3.18e-05	175	46	4	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	LRP2 NCKAP5 HUNK AOX1	3.25e-05	176	46	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA3 MPP4 NOS3 PPM1F	3.32e-05	177	46	4	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP2 HUNK SHANK2 CRB2	3.39e-05	178	46	4	544379f5a6145429762258d426b876bb36c112f5
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POGZ FBXO17 SBF1 ELMO2	3.55e-05	180	46	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	COPD-Epithelial-ATI\|World / Disease state, Lineage and Cell class	NCKAP5 SHANK2 ALS2CL PARVA	3.70e-05	182	46	4	e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP2 FBXO17 SHANK2 AOX1	3.78e-05	183	46	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCKAP5 SHANK2 ALS2CL PARVA	3.86e-05	184	46	4	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCKAP5 SHANK2 ALS2CL PARVA	3.86e-05	184	46	4	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	COPD-Epithelial-ATI\|COPD / Disease state, Lineage and Cell class	NCKAP5 SHANK2 ALS2CL PARVA	4.03e-05	186	46	4	df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	NCKAP5 HUNK SHANK2 WNK2	4.11e-05	187	46	4	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP2 FBXO17 HUNK SHANK2	4.11e-05	187	46	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NCKAP5 SHANK2 ALS2CL PARVA	4.38e-05	190	46	4	30b50d183d7649146eb1e79b47ba897355f1998a
Disease	Coronary Artery Vasospasm	ARHGAP9 NOS3	6.82e-06	3	45	2	C0010073
Disease	Diffuse Large B-Cell Lymphoma	KMT2D PRDM11 CREBBP	8.23e-05	55	45	3	C0079744
Disease	Lymphoma, Large-Cell, Follicular	KMT2D CREBBP	2.36e-04	15	45	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	KMT2D CREBBP	2.36e-04	15	45	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	KMT2D CREBBP	2.36e-04	15	45	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	KMT2D CREBBP	2.36e-04	15	45	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	KMT2D CREBBP	2.36e-04	15	45	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	KMT2D CREBBP	2.36e-04	15	45	2	C1956130
Disease	Prostatic Neoplasms	LRP2 KMT2D TAF1L CREBBP NOS3 AOX1	3.29e-04	616	45	6	C0033578
Disease	Malignant neoplasm of prostate	LRP2 KMT2D TAF1L CREBBP NOS3 AOX1	3.29e-04	616	45	6	C0376358
Disease	Squamous cell carcinoma of esophagus	KMT2D CREBBP FAT3	4.16e-04	95	45	3	C0279626
Disease	Lymphoma, Follicular	KMT2D CREBBP	4.25e-04	20	45	2	C0024301
Disease	Renal glomerular disease	CREBBP CRB2	5.64e-04	23	45	2	C0268731
Disease	Glomerulopathy Assessment	CREBBP CRB2	5.64e-04	23	45	2	C4521256
Disease	Sezary Syndrome	KMT2D CREBBP	7.79e-04	27	45	2	C0036920
Disease	neuroimaging measurement, brain volume measurement	NCKAP5 FAT3 WNK2 CRB2	9.42e-04	286	45	4	EFO_0004346, EFO_0006930
Disease	retinal detachment, retinal break	ARHGAP9 FAT3	1.31e-03	35	45	2	EFO_0005773, EFO_0010698
Disease	autism spectrum disorder (implicated_via_orthology)	POGZ SHANK2 CREBBP	1.62e-03	152	45	3	DOID:0060041 (implicated_via_orthology)
Disease	Diaphragmatic Hernia	LRP2 NOS3	1.80e-03	41	45	2	C0019284
Disease	epilepsy (implicated_via_orthology)	GRIN2C SBF1 NOS3	1.98e-03	163	45	3	DOID:1826 (implicated_via_orthology)
Disease	end stage renal disease (biomarker_via_orthology)	LRP2 NOS3	2.35e-03	47	45	2	DOID:783 (biomarker_via_orthology)
Disease	Male sterility	KMT2D NOS3	2.45e-03	48	45	2	C0917731
Disease	Male infertility	KMT2D NOS3	2.45e-03	48	45	2	C0021364
Disease	Subfertility, Male	KMT2D NOS3	2.45e-03	48	45	2	C0848676
Disease	attempted suicide	LRP2 GIGYF2 KIAA1549L	2.54e-03	178	45	3	EFO_0004321
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF2 GRIN2C	2.56e-03	49	45	2	DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DQLLSAFVPPEEPPL	BOP1	496	Q14137
LPEEVLFGNLDLLPP	CCAR2	771	Q8N163
LVLQPLLPAAPDPSD	ALS2CL	26	Q60I27
AALLPQELPAPPDEV	BAHCC1	616	Q9P281
PPELLRQLFPESPEN	BCDIN3D	51	Q7Z5W3
LPPIVDPDPLLSCDL	CREBBP	1646	Q92793
LDPQPRFLDPQALEP	AHDC1	276	Q5TGY3
EFLPLDPTQELIFPP	AOX1	206	Q06278
VLPPEAPLSSELDLP	CDCA3	111	Q99618
ILDDPFDDPPDLLIP	PPIL4	161	Q8WUA2
ALPLLPQEFPEVVPL	KCTD7	41	Q96MP8
LPLPFPLLEVAVPAA	CRB2	1216	Q5IJ48
QKDFEPLLPPLPDNI	MPP4	131	Q96JB8
PPLTIAEPLEYPNLD	KIAA1549L	1036	Q6ZVL6
ECDAAIELPINLPPP	LRP2	4366	P98164
DPELELADLAFPPPT	SBF1	341	O95248
FDVLPLLLQAPDDPP	NOS3	286	P29474
LLLQAPDDPPELFLL	NOS3	291	P29474
PDDPPELFLLPPELV	NOS3	296	P29474
PADPSLALDALPPEL	FBXO17	11	Q96EF6
PTLEELPRELFPPLF	PRAMEF12	26	O95522
FFAPVPESLLPLPVD	PIKFYVE	971	Q9Y2I7
LPPPPLELFDLDETF	IFT52	346	Q9Y366
EFLPILQEEPLPPLA	GIGYF2	66	Q6Y7W6
LQEEPLPPLALVPFT	GIGYF2	71	Q6Y7W6
LLDLENIQIPEAPPP	ELMO2	691	Q96JJ3
LPVLPDLPLPAIQAN	ELOA	506	Q14241
AELDLPRAPQPPNAL	FRS3	126	O43559
EEFLSQDQLPPPLPE	FAT3	4411	Q8TDW7
LPPLQPLAPVNLAFD	HUNK	691	P57058
PEALDELPLPPFLQP	ANKRD9	296	Q96BM1
ELPFPELERVLQAPP	RSF1	41	Q96T23
LLQDFPALLNPEDPL	PPM1F	26	P49593
PDSFDVLVPLRLPPL	ITPRIPL2	171	Q3MIP1
QPDSPEDAEPLLPLQ	NCKAP5	1741	O14513
PRLLEPPVLALDPND	TAF1L	511	Q8IZX4
PPVLALDPNDENLIL	TAF1L	516	Q8IZX4
EPEELLTPLAPALPS	POGZ	896	Q7Z3K3
LPPQVLELPEFSDPA	PRDM11	476	Q9NQV5
AINLPLSPIPFELDP	PARVA	56	Q9NVD7
LDEDFIFTEPLPPPL	SHANK2	1401	Q9UPX8
LPPTPLLLFPEEEAT	AUP1	151	Q9Y679
PEEELPLPAFEKLNP	TJAP1	301	Q5JTD0
ELPPDLLLAEPAEPA	ZXDB	226	P98169
ALQAPRPLPQLLDDP	ARHGAP9	306	Q9BRR9
SLFPDLPVDRFDPPL	ZNF469	1426	Q96JG9
EVLLPAAPELLPQFP	WNK2	1056	Q9Y3S1
EESPLLPLPEEPQLC	KMT2D	721	O14686
PLAPADEDELLPLIP	NACA	1831	E9PAV3
PFLPLFPELEDLPLL	GRIN2C	1041	Q14957
FPELEDLPLLGPEQL	GRIN2C	1046	Q14957