Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphothreonine residue binding

PIN1 NEDD4

5.23e-053842GO:0050816
DomainWW

WWC2 ITCH HECW2 PIN1 DMD SMURF2 NEDD4

1.11e-0947807PF00397
DomainWW

WWC2 ITCH HECW2 PIN1 DMD SMURF2 NEDD4

1.29e-0948807SM00456
DomainWW_DOMAIN_2

WWC2 ITCH HECW2 PIN1 DMD SMURF2 NEDD4

2.01e-0951807PS50020
DomainWW_DOMAIN_1

WWC2 ITCH HECW2 PIN1 DMD SMURF2 NEDD4

2.01e-0951807PS01159
DomainWW_dom

WWC2 ITCH HECW2 PIN1 DMD SMURF2 NEDD4

2.32e-0952807IPR001202
DomainHECT

ITCH HECW2 SMURF2 NEDD4

5.08e-0627804PF00632
DomainHECTc

ITCH HECW2 SMURF2 NEDD4

5.08e-0627804SM00119
DomainHECT_dom

ITCH HECW2 SMURF2 NEDD4

5.08e-0627804IPR000569
DomainHECT

ITCH HECW2 SMURF2 NEDD4

5.08e-0627804PS50237
DomainCXorf40

EOLA2 EOLA1

1.81e-052802IPR033615
DomainC2

WWC2 ITCH HECW2 BCR SMURF2 NEDD4

3.29e-05142806PS50004
Domain-

WWC2 ITCH HECW2 BCR SMURF2 NEDD4

4.15e-051488062.60.40.150
DomainASCH_domain

EOLA2 EOLA1

5.42e-053802IPR007374
DomainASCH

EOLA2 EOLA1

5.42e-053802SM01022
DomainC2_dom

WWC2 ITCH HECW2 BCR SMURF2 NEDD4

7.35e-05164806IPR000008
DomainC2

ITCH HECW2 BCR SMURF2 NEDD4

2.48e-04131805PF00168
DomainC2

ITCH HECW2 BCR SMURF2 NEDD4

3.05e-04137805SM00239
DomainLAM_G_DOMAIN

FAT1 FAT3 LAMA5

5.73e-0438803PS50025
DomainLaminin_G_2

FAT1 FAT3 LAMA5

6.67e-0440803PF02210
DomainEGF-like_dom

FAT1 FCGBP FAT3 PCSK6 LAMA5 ADAM12

6.97e-04249806IPR000742
DomainLamG

FAT1 FAT3 LAMA5

8.83e-0444803SM00282
DomainLaminin_G

FAT1 FAT3 LAMA5

1.97e-0358803IPR001791
DomainPUA-like_domain

EOLA2 EOLA1

2.96e-0319802IPR015947
DomainEGF

FAT1 FCGBP FAT3 PCSK6 LAMA5

3.38e-03235805SM00181
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

ITCH HECW2 SMURF2 NEDD4

1.38e-071987421572392
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

ITCH HECW2 SMURF2 NEDD4

2.12e-072187437005481
Pubmed

Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

SHROOM3 ITCH DMD SMURF2 NEDD4

2.75e-075587531985874
Pubmed

Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment.

ITCH SMURF2 NEDD4

3.01e-07687320676133
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

ITCH HECW2 SMURF2 NEDD4

5.23e-072687426949039
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

ITCH SMURF2 NEDD4

5.25e-07787323644597
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

ITCH SMURF2 NEDD4

8.39e-07887317719543
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

EHBP1 TMX1 RADX TBC1D1 CAMK2B PPP1R12A WRN C3 PCARE KATNIP EIF2AK1 BCR GCN1 PRRC2B RSRC1

9.22e-071321871527173435
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

ITCH SMURF2 NEDD4

1.79e-061087325092867
Pubmed

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

ITCH SMURF2 NEDD4

2.46e-061187317996703
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

ITCH SMURF2 NEDD4

2.46e-061187322773947
Pubmed

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.

ITCH SMURF2 NEDD4

3.27e-061287324107629
Pubmed

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

ITCH SMURF2 NEDD4

5.39e-061487326147758
Pubmed

Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice.

DMD ADAM12

6.19e-06287217982130
Pubmed

Substrate clustering potently regulates the activity of WW-HECT domain-containing ubiquitin ligases.

SMURF2 NEDD4

6.19e-06287229463679
Pubmed

Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.

ITCH NEDD4

6.19e-06287234260096
Pubmed

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.

DMD ADAM12

6.19e-06287212915458
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TUBGCP6 SHROOM3 HECW2 PHRF1 AKNA TRIOBP LAMA5 CACNA1G BCR

7.30e-0652987914621295
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

ITCH SMURF2 NEDD4

1.00e-051787328292929
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ITCH HECW2 LAMA5 DMD BCR GCN1 NEDD4

1.41e-0531387738270169
Pubmed

Rare Variants in LAMA5 Gene associated with FLT4 and FOXC2 Mutations in Primary Lymphedema May Contribute to Severity.

FLT4 LAMA5

1.85e-05387229908552
Pubmed

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

FAT1 FAT3

1.85e-05387215744052
Pubmed

Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.

ITCH NEDD4

1.85e-05387215703212
Pubmed

Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.

C3 DMD

1.85e-05387221060153
Pubmed

Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells.

PIN1 NEDD4

1.85e-05387219682092
Pubmed

The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin.

ITCH NEDD4

1.85e-05387215013426
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

EHBP1 SHROOM3 ITCH TBC1D1 CAMK2B PPP1R12A RIN2 SREBF2 TRIOBP NLRC5 KATNIP ZFHX3 BCR SMURF2

1.89e-051489871428611215
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ORC1 FAT1 SHROOM3 PPRC1 AKNA NLRC5 LAMA5 BCR GCN1 SMURF2 PRRC2B TJP3

1.97e-051105871235748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TUBGCP6 FAT1 ITCH ARHGAP23 DROSHA PPP1R12A FAT3 PCSK6 PHRF1 ZFHX3 BCR PRRC2B

2.17e-051116871231753913
Pubmed

Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.

MAPK8IP1 ARHGAP23 PPP1R12A NEDD4

2.48e-056787429254152
Pubmed

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

PPP1R12A ZFHX3 ARMC9 ADAM12

3.12e-057187423400010
Pubmed

Common variations in 4p locus are related to male completed suicide.

WFS1 TBC1D1

3.70e-05487219115052
Pubmed

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

PIN1 SMURF2

3.70e-05487219122240
Pubmed

Analysis of gene rearrangements using a fluorescence in situ hybridization method in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.

KMT2A BCR

3.70e-05487218617057
Pubmed

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

SMURF2 NEDD4

3.70e-05487225438670
Pubmed

MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.

ITCH NEDD4

3.70e-05487223253940
Pubmed

ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.

ITCH SREBF2

3.70e-05487225777360
Pubmed

The ubiquitin-protein ligase Itch regulates p73 stability.

ITCH NEDD4

3.70e-05487215678106
Pubmed

Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.

ITCH NEDD4

3.70e-05487220522958
Pubmed

Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.

DROSHA KMT2A

3.70e-05487217581865
Pubmed

The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.

ITCH NEDD4

3.70e-05487227466427
Pubmed

ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice.

DMD ADAM12

3.70e-05487212414501
Pubmed

130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.

EOLA2 EOLA1

3.70e-0548728717057
Pubmed

Prognostic impact of KMT2A-AFF1-positivity in 926 BCR-ABL1-negative B-lineage acute lymphoblastic leukemia patients treated in GIMEMA clinical trials since 1996.

KMT2A BCR

3.70e-05487234048072
Pubmed

LncRNA FIRRE stimulates PTBP1-induced Smurf2 decay, stabilizes B-cell receptor, and promotes the development of diffuse large B-cell lymphoma.

BCR SMURF2

3.70e-05487235416325
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EHBP1 WWC2 SHROOM3 ITCH TBC1D1 PPP1R12A KMT2A BCR RSRC1 NEDD4

5.88e-05861871036931259
Pubmed

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

ITCH NEDD4

6.16e-05587221936852
Pubmed

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

ITCH NEDD4

6.16e-05587225631046
Pubmed

Function of WW domains as phosphoserine- or phosphothreonine-binding modules.

PIN1 NEDD4

6.16e-05587210037602
Pubmed

A Tunable Brake for HECT Ubiquitin Ligases.

ITCH NEDD4

6.16e-05587228475870
Pubmed

The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.

DROSHA DMD

6.16e-05587231686651
Pubmed

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

ITCH NEDD4

6.16e-05587222385262
Pubmed

Inhibition of HECT E3 ligases as potential therapy for COVID-19.

SMURF2 NEDD4

6.16e-05587233762578
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ORC1 SHROOM3 DROSHA PPP1R12A PHRF1 WRN TRIOBP LAMA5 KMT2A ZFHX3 WDR12 SRFBP1 RSRC1

8.70e-051497871331527615
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

ITCH NEDD4

9.22e-05687215252135
Pubmed

The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.

ITCH NEDD4

9.22e-05687220491914
Pubmed

[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia].

KMT2A BCR

9.22e-05687215968309
Pubmed

A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.

HECW2 NEDD4

9.22e-05687212890487
Pubmed

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

ITCH NEDD4

9.22e-05687226854353
Pubmed

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

SMURF2 NEDD4

9.22e-05687229964046
Pubmed

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.

ITCH NEDD4

9.22e-05687218544533
Pubmed

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

PIN1 NEDD4

9.22e-05687221685363
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

ITCH NEDD4

9.22e-05687237156795
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

ITCH NEDD4

9.22e-05687211748237
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

ITCH HECW2 PHRF1 NEDD4

9.77e-059587429643511
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

SMURF2 NEDD4

1.29e-04787230587574
Pubmed

Molecular and phenotypic variation in patients with severe Hunter syndrome.

EOLA2 EOLA1

1.29e-0478729147653
Pubmed

Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.

FAT1 FAT3

1.29e-04787222510986
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

ITCH NEDD4

1.29e-04787211046148
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT1 FAT3

1.29e-04787216059920
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SHROOM3 ARHGAP23 PHRF1 NLGN1

1.34e-0410387410819331
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PPRC1 LAMA5 KATNIP PRRC2B

1.44e-041058749628581
Pubmed

Novel interaction partners of the CD2BP2-GYF domain.

AKNA NEDD4

1.72e-04887216000308
Pubmed

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

ITCH SMURF2

1.72e-04887219307600
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

ITCH NEDD4

1.72e-04887211244092
Pubmed

Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.

ITCH NEDD4

1.72e-04887231578285
Pubmed

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

ITCH NEDD4

2.20e-04987214973438
Pubmed

Genetic modifiers of muscular dystrophy: implications for therapy.

DMD ADAM12

2.20e-04987216916601
Pubmed

A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.

DROSHA DMD

2.20e-04987222000014
Pubmed

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

SMURF2 NEDD4

2.20e-04987215496141
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

WWC2 PIN1 KATNIP WDR12 PRRC2B

2.25e-0421887533378226
Pubmed

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

ITCH HECW2

3.35e-041187234927784
Pubmed

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

ITCH NEDD4

3.35e-041187221191027
Pubmed

Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.

FLT4 LAMA5

3.35e-041187227899284
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

ITCH NEDD4

3.35e-041187225963657
Pubmed

HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.

ITCH NEDD4

4.02e-041287223071112
Pubmed

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.

FLT4 LAMA5

4.74e-041387227789626
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

ITCH NEDD4

4.74e-041387223146885
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

DROSHA SREBF2

5.52e-041487210976766
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

ITCH SMURF2

5.52e-041487231015455
Pubmed

Tie1 is required for lymphatic valve and collecting vessel development.

FLT4 LAMA5

5.52e-041487225576926
Pubmed

Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

FLT4 LAMA5

5.52e-041487222665518
Pubmed

AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis.

ITCH PIN1

5.52e-041487236806887
Pubmed

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.

SMURF2 NEDD4

5.52e-041487229263404
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PPRC1 TBC1D1 KATNIP NLGN1 PRRC2B NEDD4

5.63e-0440787612693553
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TMX1 SHROOM3 PPRC1 LAMA5 CACNA1G DMD EIF2AK1 BCR

6.09e-0475487835906200
Pubmed

Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.

PIN1 DMD

6.36e-041587211741599
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

ITCH NEDD4

6.36e-041587223236378
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MAPK8IP1 SHROOM3 ITCH CAMK2B PPP1R12A TRIOBP BCR PRRC2B NEDD4

6.86e-0496387928671696
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

ITCH SMURF2

7.26e-041687225723849
InteractionTRIM66 interactions

TUBGCP6 FAT1 ITCH DROSHA FAT3 PCSK6 BCR PRRC2B

2.05e-06205838int:TRIM66
InteractionLDLRAD4 interactions

WWC2 ITCH HECW2 SMURF2 NEDD4

4.41e-0659835int:LDLRAD4
InteractionFBXL15 interactions

ITCH HECW2 SMURF2 NEDD4

5.87e-0629834int:FBXL15
InteractionILDR1 interactions

ITCH HECW2 NEDD4

1.09e-0511833int:ILDR1
InteractionPRRG1 interactions

ITCH HECW2 NEDD4

2.96e-0515833int:PRRG1
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ITCH HECW2 BCR SMURF2

2.22e-0636474823
GeneFamilyCadherin related

FAT1 FAT3

8.77e-041747224
ToppCell15-Airway-Epithelial-Submucosal_gland|Airway / Age, Tissue, Lineage and Cell class

SHROOM3 FCGBP DBNDD1 KIF12 GALNT4 TJP3

1.36e-06180866283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHROOM3 OASL SREBF2 NLRC5 TJP3

2.09e-051728656ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 NECAB1 PCSK6 BCR ADAM12

2.27e-051758659d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 NECAB1 PCSK6 BCR ADAM12

2.27e-05175865f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EHBP1 FLT4 PCSK6 BCR ADAM12

2.27e-051758650801cccec6915aefc135262fc74580280fd51aa5
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EHBP1 FLT4 PCSK6 BCR ADAM12

2.27e-0517586509163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

ITCH ADCK1 PHRF1 WRN SLA

2.46e-05178865536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT4 NECAB1 PCSK6 BCR ADAM12

2.67e-05181865b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT4 NECAB1 PCSK6 BCR ADAM12

2.67e-05181865cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT4 NECAB1 PCSK6 BCR ADAM12

2.67e-05181865ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

WWC2 SHROOM3 WFS1 LAMA5 DMD

2.89e-05184865561592edc3083fad41b91811151b442207c65dd9
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 ARHGAP23 ARMC9 BCR ADAM12

2.96e-05185865bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SSC5D NECAB1 PCSK6 TRIOBP C3

3.20e-05188865aa516273cdde53c8c0295f06830972388f890c97
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

NECAB1 PCSK6 C3 ARMC9 NLGN1

3.20e-05188865ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellMonocytes-Tissue-resident_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

CHRNA6 FCGBP LPCAT2 C3 ZFHX3

3.36e-0519086507215e8f292cb54c670037aaf28393cddbe5548c
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

FLT4 ARHGAP23 WFS1 HECW2 PCSK6

3.62e-0519386525bdc557055b5bce6a21f8696b48e991c696b979
ToppCellMonocytes-Tissue-resident_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

CHRNA6 FCGBP LPCAT2 C3 SMURF2

3.62e-05193865198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SSC5D FAT1 NECAB1 ZFHX3 DMD

3.62e-05193865000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

EHBP1 LPCAT2 PCSK6 C3 ZFHX3

3.81e-05195865a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellMS-mono1|MS / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.00e-0519786532be48ee2a1397ed8f1ee8e60067dd9a96bece39
ToppCellMS-mono1-|MS / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.00e-051978654b038a193ecc1df65bcb608091c513ddafd6c818
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHROOM3 NECAB1 SREBF2 C3 ARMC9

4.19e-051998652dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM156 AKNA NLRC5 ADAM12 SLA

4.19e-05199865fbdde57dd88656621801e65ee2818251588f3874
ToppCellCOVID-mono1|COVID / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.29e-05200865bd002c54305c746c07b7418a2084195e9c852ec5
ToppCellIIH-mono1-|IIH / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.29e-05200865555207143ecc89cdd55c30a513b31cf5dfd26dbc
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SSC5D FAT1 PPP1R12A ZFHX3 DMD

4.29e-05200865f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT4 ARHGAP23 WFS1 HECW2 PCSK6

4.29e-05200865f99d0d3f51b4893fa7898c5b435494358a654cbd
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FLT4 ARHGAP23 WFS1 HECW2 PCSK6

4.29e-05200865e65d4ae3d48f68c12edd5dc2c2f4e25e4acfadf1
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Lymphatic|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

FLT4 ARHGAP23 WFS1 HECW2 PCSK6

4.29e-052008654ec8e30dd241d83a1bba1c5967b6a4656afbfafd
ToppCellCOVID-mono1-|COVID / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.29e-05200865445a1aab962673dcc926c33ce9bed5ede9c41c57
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FAT1 PERM1 ZFHX3 ARMC9 DMD

4.29e-05200865c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SSC5D FAT1 PPP1R12A ZFHX3 DMD

4.29e-0520086567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellIIH-mono1|IIH / Condition, Cell_class and T cell subcluster

FCGBP LPCAT2 RIN2 C3 ZFHX3

4.29e-0520086585c090fa714a6a02703ed38d3d49788ec0119666
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

SSC5D FAT1 PPP1R12A ZFHX3 DMD

4.29e-052008658bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Calb1_(Superficial_layer_pyramidal_cells--Layer_2/3)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

WFS1 SPATA21 OTOP3 MBOAT4

1.04e-041268647dcc79bf35482e8e5e5a1de7279ba080edb70522
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CHRNA6 SHROOM3 C3 NLGN1

1.07e-041278645b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

MSLNL MROH5 KIF12 TJP3

2.31e-0415586457259549d7ad97d9f628b821417be5ddac7dbff7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCGBP LPCAT2 C3 CPXCR1

2.43e-04157864d4908cafd8870c1c225817f589ea2bce116ac7ab
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SSC5D FAT1 FAT3 ZFHX3

2.43e-04157864b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 FAT3 NLRC5 ADAM12

2.49e-0415886412661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 FAT3 NLRC5 ADAM12

2.49e-04158864e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 FAT3 NLRC5 ADAM12

2.49e-041588640792c39e6fc0745095af7812de2d50949540d60f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP23 HECW2 RIN2 NLRC5

2.55e-04159864d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

WWC2 FAT1 SHROOM3 LAMA5

2.55e-041598648680b054622f573a82b1625fb93c2d5db81d1034
ToppCellRV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

PPP1R12A FAT3 ZFHX3 DMD

2.61e-0416086429c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCellVE-mono3|VE / Condition, Cell_class and T cell subcluster

LPCAT2 RIN2 C3 CACNA1G

2.67e-041618647df3fefc55ab43b897fc78d1f0c7383b10ac33d5
ToppCellRV-13._Vascular_Smooth_Muscle|RV / Chamber and Cluster_Paper

PPP1R12A FAT3 ZFHX3 DMD

2.67e-0416186447b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCellVE-mono3-|VE / Condition, Cell_class and T cell subcluster

LPCAT2 RIN2 C3 CACNA1G

2.67e-041618644e45bf7eceb0ee30dec4d8852778366776ea5a8f
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ORC1 MSLNL MBOAT4

2.83e-046686385e0027bf0d4ebdcb6cac358aedd1d74aa83c612
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ORC1 MSLNL MBOAT4

2.83e-04668636cf03dd1db7607684cdcca7df08933f8cdc3adef
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPR33 PERM1 C3 NLGN1

2.86e-041648641cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellILEUM-non-inflamed-(1)_Cytotoxic_T_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

OASL AKNA NLRC5 SLA

3.00e-0416686467f9d88329724cdda11bf76e964f66456ff6fb46
ToppCellfacs-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 ARHGAP23 FAT3 CACNA1G

3.00e-041668648d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ORC1 NECAB1 NLGN1 ADAM12

3.00e-0416686449103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCellfacs-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 ARHGAP23 FAT3 CACNA1G

3.00e-04166864f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCellfacs-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 ARHGAP23 FAT3 CACNA1G

3.00e-04166864a5074c96c6561273029aceb93402a7e038140f50
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP LPCAT2 C3 ZFHX3

3.21e-041698640867528101767fc65e93b3561480bf830c50368d
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ORC1 SHROOM3 FAM114A2 ADAM12

3.28e-04170864b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 PCSK6 BCR ADAM12

3.43e-04172864b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 PCSK6 BCR ADAM12

3.43e-041728642f1673fcb2356684d60871debb0f159aec553a1c
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 TRIOBP KATNIP ZFHX3

3.51e-0417386485083b9ce20351dd69aa2327ad087b848b4307ff
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FAT3 ZFHX3 NLGN1 DMD

3.51e-04173864cb6389536195443633adb06e5f1b7483530773d1
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ORC1 MAPK8IP1 ARHGAP23 LAMA5

3.58e-04174864207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SSC5D ARHGAP23 HECW2 KATNIP

3.66e-0417586412f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCellDendritic_Cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

TMEM156 FCGBP RIN2 OTOP3

3.66e-04175864584290a51f9975782a5ac8c6ad67c778d8323f8c
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

DBNDD1 ARHGAP23 WFS1 LAMA5

3.74e-04176864458720776b0151cd55acc352d509599cb62f0ca8
ToppCelldroplet-Tongue-nan-24m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHROOM3 OASL SREBF2 NLRC5

3.74e-041768649739b0653c511ab017507a0c7ee4f6d7082e87db
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ITCH ADCK1 PHRF1 WRN

3.91e-041788649d575902d3dbe33437c9d4200df093a741269803
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP23 AKNA C3 SLA

3.91e-04178864d9eba884e18a0c89bdc70c194bfe4d62cca164fa
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP23 AKNA C3 SLA

3.91e-04178864b03aa1de9d20895ebad55f6fcd6fe7a49335db5a
ToppCelldroplet-Tongue-nan-24m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHROOM3 OASL SREBF2 NLRC5

3.91e-04178864a3176b2b335db22bb0fb71aafa5d7a287809396e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP23 AKNA C3 SLA

3.91e-041788640f5cf34609df791c8baebfdc6590f6eb4dbe0509
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

FLT4 HECW2 ADAM12 SLA

3.99e-04179864cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TMEM156 NLGN1 ADAM12 SLA

3.99e-04179864bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCellCOVID-19-Heart-VSMC|Heart / Disease (COVID-19 only), tissue and cell type

FAT1 TBC1D1 PPP1R12A ZFHX3

3.99e-04179864a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT4 HECW2 RIN2 LAMA5

4.07e-04180864d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

FAT3 ZFHX3 NLGN1 DMD

4.07e-04180864d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellAT1_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

WWC2 ARHGAP23 WFS1 LAMA5

4.07e-04180864e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW2 FAT3 LAMA5 NEDD4

4.07e-0418086441e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WWC2 SHROOM3 NLGN1 TJP3

4.16e-04181864b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

FLT4 HECW2 LAMA5 NEDD4

4.16e-04181864c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 NECAB1 FAT3 NLGN1

4.16e-041818646956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LPCAT2 OASL CACNA1G SLA

4.25e-041828644234d0cc57b5266a5e03133c75c7918abe48465e
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

FLT4 HECW2 RIN2 NEDD4

4.25e-041828648b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 WFS1 HECW2 KCNG4

4.25e-0418286441b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 WFS1 HECW2 KCNG4

4.25e-041828645e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 WFS1 HECW2 KCNG4

4.25e-04182864b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

TBC1D1 PPP1R12A FAT3 DMD

4.34e-04183864818fd886e0188091310825f9145fa53328f2c979
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

WWC2 SHROOM3 WFS1 LAMA5

4.34e-041838647b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCellBasal|World / shred by cell class for mouse tongue

WWC2 LAMA5 ZFHX3 NEDD4

4.34e-04183864c6729a207526ff4aa48176207b9353176f631fea
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FCGBP LPCAT2 C3 SLA

4.34e-0418386462f76907e501bba6e1010b5c447faed5f0ef93a7
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

TBC1D1 PPP1R12A FAT3 DMD

4.34e-04183864cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 C3 NLGN1 TJP3

4.43e-0418486442ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell(6)_Endothelial-F_(Lymphatics)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FLT4 ARHGAP23 WFS1 PCSK6

4.43e-0418486403ea613e00b45c81b752c14505a0538d698f551e
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R12A LAMA5 ZFHX3 BCR

4.43e-0418486494748f63947db79a6b4540e3090a63689fdd9452
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R12A LAMA5 ZFHX3 BCR

4.43e-04184864819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT1 ZFHX3 DMD ADAM12

4.43e-04184864327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Dpy19l1_(Neuron.Gad1Gad2.Cplx3-Dpy19l1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ORC1 RADX PERM1

4.45e-04778634a0a2f1a021790ff598a8655811eac1c367316b3
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Dpy19l1_(Neuron.Gad1Gad2.Cplx3-Dpy19l1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ORC1 RADX PERM1

4.45e-0477863459fe29a53b88af77a4ced7b11fa1d0a17fec8e5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

WWC2 SHROOM3 WFS1 LAMA5

4.52e-041858641c222f7285d6e3dae0354dc7e853ddc0ea55e63e
Diseaseperiodontitis

TBC1D1 FAT3 ZFHX3 NLGN1 DMD SMURF2

3.78e-05223826EFO_0000649
Diseaseserum gamma-glutamyl transferase measurement

EHBP1 WWC2 AFDN-DT SPATA21 OASL TRIOBP KMT2A PERM1 C3 GCN1 TJP3

4.47e-059148211EFO_0004532
DiseaseSclerocystic Ovaries

FLT4 LPCAT2 ARHGAP23 SPATA21 DMD

5.21e-05144825C1136382
DiseasePolycystic Ovary Syndrome

FLT4 LPCAT2 ARHGAP23 SPATA21 DMD

5.21e-05144825C0032460
Diseaseresponse to hydrochlorothiazide, fasting blood glucose measurement

ZFHX3 ARMC9 ADAM12

2.88e-0446823EFO_0004465, EFO_0005202
Diseaseosteoarthritis, hip, osteoarthritis, knee

PIN1 HLA-DRB3 KIF12

6.95e-0462823EFO_0004616, EFO_1000786
DiseaseMalignant neoplasm of breast

EHBP1 CATSPERE SPATA21 PIN1 SREBF2 NFYC NLRC5 DMD ADAM12 NEDD4

7.79e-0410748210C0006142
Diseasenasopharyngeal neoplasm

FLT4 KMT2A ZFHX3 ADAM12

8.46e-04151824EFO_0004252
Diseasecleft lip

EHBP1 SSC5D WFS1 KCNG4 HLA-DRB3

1.19e-03284825EFO_0003959
DiseasePrecursor B-cell lymphoblastic leukemia

KMT2A BCR

1.55e-0321822C1292769
DiseaseJoubert syndrome 1

KATNIP ARMC9

1.55e-0321822C4551568
Diseasesevere acute respiratory syndrome, COVID-19

PCSK6 WRN ZFHX3 DMD EIF2AK1 SLA

1.55e-03447826EFO_0000694, MONDO_0100096
DiseaseHeadache, type 2 diabetes mellitus

PCSK6 NLGN1

1.86e-0323822HP_0002315, MONDO_0005148
Diseasesmall vessel stroke

AFDN-DT TBC1D1 WDR12

2.45e-0396823EFO_1001504
DiseaseS-warfarin measurement

TBC1D1 NLGN1 ADAM12

2.53e-0397823EFO_0803323
DiseaseTYPE 2 DIABETES MELLITUS

MAPK8IP1 WFS1

2.75e-0328822125853
Diseaseretinal degeneration (biomarker_via_orthology)

C3 DMD

2.75e-0328822DOID:8466 (biomarker_via_orthology)
DiseaseType 2 diabetes mellitus

MAPK8IP1 WFS1

2.75e-0328822cv:C0011860

Protein segments in the cluster

PeptideGeneStartEntry
KTVETRWRPLLSSQR

EOLA1

21

Q8TE69
KTVETRWRPLLSSQR

EOLA2

21

Q96DE9
RSKSWPVFLQVHLRS

ADCK1

71

Q86TW2
HTTDSFKSWTRIRVP

CATSPERE

261

Q5SY80
STSEQEKRLTWPRRS

BCR

301

P11274
RVSSRVIPFRWVTSK

AFDN-DT

226

Q9Y6Z5
SQQHRTPRWASSIVL

GPR33

136

Q49SQ1
PSRSSKITHRIHWES

C3

1301

P01024
PPSQTWARRHKRETL

ADAM12

196

O43184
INASWRSIHKRVSER

DMD

2666

P11532
INHKTRFRLSTSWRV

CPXCR1

126

Q8N123
RKRPEIWSRSAIVHS

KIAA1107

831

Q9UPP5
WRLPKLNHRFTTRSE

RADX

351

Q6NSI4
RRSTIISNTTNPIWH

HECW2

231

Q9P2P5
GRPQKSSTTRLHIEW

FAT1

1331

Q14517
TRPRQKSWLVRHFSL

OTOP3

61

Q7RTS5
HESRRTQWKRPTPQD

NEDD4

631

P46934
HSWQDRVSRSSSPLK

MAPK8IP1

186

Q9UQF2
SSRTAPSKVQRRGWH

KATNIP

121

O60303
RTPSRSRWRSEQEHT

KATNIP

881

O60303
KCPRERSHSDWTQTR

KIF12

556

Q96FN5
RWRLTTSHPGEQRET

ARMC9

341

Q7Z3E5
QQRETRRPASHSSRW

KCNG4

186

Q8TDN1
SWTQRRTQPLQERSH

EXOC3-AS1

61

Q8N2X6
TWRDVQHLLVKTSRP

PCSK6

441

P29122
LVKHSQSRRPSSWRQ

PIN1

61

Q13526
QSRRPSSWRQEKITR

PIN1

66

Q13526
TVSKSVCAEPWRHQR

FAM157A

311

C9JC47
REKWPQTRSHSPERK

PHRF1

1181

Q9P1Y6
VSDVVSTRPRWNTHV

TUBGCP6

1256

Q96RT7
QWNRTVKPTRTRVVS

FMO6P

496

O60774
HVWKIVVSNTPRTLR

GCN1

1906

Q92616
QKARSHPTVRAWLRS

MSLNL

566

Q96KJ4
SRQRSRPGRWHKVSV

LAMA5

3416

O15230
TDWADRHNPETRRKT

NLGN1

481

Q8N2Q7
TLRAWIHTEDNKRRT

NFYC

81

Q13952
PKSSWVKRHRSSFRN

LRRC66

131

Q68CR7
VTLHSRWVQRTKARL

NLRC5

541

Q86WI3
NPISSWNVKRARDIH

OASL

341

Q15646
THPITGWRRKITQTA

LPCAT2

96

Q7L5N7
SWTPAEHVAKRIESR

ORC1

201

Q13415
TRTTTWQRPTLESVR

ITCH

381

Q96J02
HPSVTSALTVEWRAR

HLA-DRB3

206

P79483
TSKRRLSHQPLQWVV

CHRNA6

406

Q15825
HVPEQKSRVDWRRTK

CCDC82

16

Q8N4S0
GRERWNHVTTTTKRP

CD99L2

91

Q8TCZ2
RRPTSWLDEQRRHSI

CACNA1G

2256

O43497
WTNRNGKRTPTHTSR

EIF2AK1

476

Q9BQI3
SWTRTRAEQSHEKQP

DBNDD1

121

Q9H9R9
HSLTLSARWPRKLQV

FCGBP

4541

Q9Y6R7
WHSVPKQERDRRISR

GALNT4

286

Q8N4A0
RPQKSSTARLHIEWI

FAT3

1336

Q8TDW7
QSPQHATDRWRRETT

AKNA

271

Q7Z591
RRSRRKSSKAHSWQP

EHBP1

46

Q8NDI1
RARNTAHEWIRKSLT

FAM114A2

331

Q9NRY5
WTLERTHRISVFSRK

MBOAT4

291

Q96T53
ILREPTFRWTSLKHS

KMT2A

611

Q03164
TFRWTSLKHSRSEPQ

KMT2A

616

Q03164
TPRRAKLHTVSTTVW

PERM1

271

Q5SV97
SRSRSRSLSPPHKRW

PPRC1

1451

Q5VV67
DAHTWTKSRRPIIRP

DUSP21

131

Q9H596
PTRTHWVPQADKRRR

PCARE

996

A6NGG8
QDSARRDRWSHPTTI

MROH5

46

Q6ZUA9
HRPEAKPQRTSRRVW

NRAC

56

Q8N912
PVTLRQKTVDWRRVS

SLA

191

Q13239
RPRTSQSEETRVWHR

CAMK2B

631

Q13554
VNHRSPSREKKRARW

DROSHA

351

Q9NRR4
REHNSDSRKWLSSVP

SPATA21

451

Q7Z572
RHRERPSSWSSLDQK

SHROOM3

396

Q8TF72
TETSSAERKRRLPVW

WRN

1396

Q14191
TRRPTTEAPQRWTSH

SSC5D

681

A1L4H1
RNWIEALRKTVRPTS

TRIOBP

1876

Q9H2D6
RVQKWQSHRDKPTSV

TMEM156

241

Q8N614
LNHITRTTQWERPTR

SMURF2

176

Q9HAU4
DTLRQWHKRRTTNRT

RIN2

766

Q8WYP3
WHKRRTTNRTIPSVD

RIN2

771

Q8WYP3
HNTRRTSWIDPRDRL

WWC2

31

Q6AWC2
KRTHSRVRSHSWKRN

SRRM5

296

B3KS81
HQFPTDTIQRSKWIR

THAP9

26

Q9H5L6
HPSWEASRRRKEQQS

SRFBP1

401

Q8NEF9
SSWRRHTVVVQSPLT

ARHGAP23

1401

Q9P227
PHSRSSVTFWRHRKQ

SREBF2

566

Q12772
GKWVPERRSQQTHTE

FLT4

276

P35916
GTPVKTRRHSWRQQI

TBC1D1

651

Q86TI0
RRTFVSKESPHWQSK

PRRC2B

1216

Q5JSZ5
SKSRSWSRDLQPRSH

RSRC1

46

Q96IZ7
IWEQHTATLSKDPRR

TJP3

6

O95049
STDRHIRLWDPRTKD

WDR12

316

Q9GZL7
APWTHGRRSNVRVIT

TMX1

21

Q9H3N1
HASRKSWPQVVSRAS

ZFHX3

3611

Q15911
PTRRHVKIEHDWRST

WFS1

856

O76024
PREKRRSTGVSFWTQ

PPP1R12A

846

O14974
IQWPGKRSSRRVQRH

NECAB1

176

Q8N987