Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	RANBP6 CSE1L IPO4	1.07e-05	32	27	3	GO:0140142
GeneOntologyMolecularFunction	nuclear import signal receptor activity	RANBP6 IPO4	3.30e-04	20	27	2	GO:0061608
GeneOntologyMolecularFunction	molecular carrier activity	RANBP6 CSE1L IPO4	4.09e-04	108	27	3	GO:0140104
GeneOntologyMolecularFunction	nuclear localization sequence binding	RANBP6 IPO4	6.05e-04	27	27	2	GO:0008139
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD6 ERCC3 TOP2B	6.57e-04	127	27	3	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent activity	CHD6 ERCC3 TOP2B KIF1B DNAI2	1.25e-03	614	27	5	GO:0140657
Domain	ARM-type_fold	RANBP6 CSE1L IPO4 HECTD1 CEBPZ	1.11e-04	339	27	5	IPR016024
Domain	IMPORTIN_B_NT	CSE1L IPO4	1.81e-04	14	27	2	PS50166
Domain	IBN_N	CSE1L IPO4	2.09e-04	15	27	2	PF03810
Domain	IBN_N	CSE1L IPO4	2.39e-04	16	27	2	SM00913
Domain	Importin-beta_N	CSE1L IPO4	2.70e-04	17	27	2	IPR001494
Domain	-	RANBP6 CSE1L IPO4 HECTD1	2.75e-04	222	27	4	1.25.10.10
Domain	ARM-like	RANBP6 CSE1L IPO4 HECTD1	5.77e-04	270	27	4	IPR011989
Domain	HEAT	RANBP6 IPO4	2.18e-03	48	27	2	PF02985
Domain	HEAT	RANBP6 IPO4	3.16e-03	58	27	2	IPR000357
Domain	HEAT_REPEAT	RANBP6 IPO4	4.57e-03	70	27	2	PS50077
Domain	WD40	AAMP DNAI2 FBXW7	6.03e-03	259	27	3	PF00400
Domain	WD40	AAMP DNAI2 FBXW7	6.62e-03	268	27	3	SM00320
Domain	WD40_repeat	AAMP DNAI2 FBXW7	6.90e-03	272	27	3	IPR001680
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	ERCC3 TAF1L SUPT6H	1.66e-04	81	19	3	M865
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	ERCC3 TAF1L SUPT6H	1.78e-04	83	19	3	MM15314
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	LARP1 FASTKD5 CHD6 CLGN HECTD1 CEBPZ CCDC47 RCAN3	5.84e-08	733	27	8	34672954
Pubmed	FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.	IPO4 HECTD1 CEBPZ FBXW7	3.95e-07	78	27	4	25720964
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	RANBP6 FASTKD5 CLGN CSE1L IPO4 HECTD1 CEBPZ CCDC47	3.95e-07	942	27	8	31073040
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	LARP1 RANBP6 FASTKD5 CLGN CSE1L IPO4 CEBPZ CCDC47 TOP2B	8.31e-07	1440	27	9	30833792
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	LARP1 ERCC3 HECTD1 CEBPZ SUPT6H TOP2B	9.37e-07	440	27	6	34244565
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	FASTKD5 AAMP ERCC3 CSE1L IPO4 SUPT6H	3.77e-06	560	27	6	35241646
Pubmed	The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling.	CHD6 FBXW7	5.80e-06	5	27	2	36473865
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	LARP1 FASTKD5 CSE1L IPO4 CEBPZ CCDC47 SUPT6H TOP2B	8.61e-06	1425	27	8	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	LARP1 CSE1L IPO4 HECTD1 CEBPZ SUPT6H	9.06e-06	653	27	6	22586326
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FASTKD5 CRYBG3 IPO4 CEBPZ CCDC47 SUPT6H TOP2B TTLL5	1.17e-05	1487	27	8	33957083
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	LARP1 IPO4 HECTD1 TOP2B	1.75e-05	202	27	4	33005030
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	ERCC3 CSE1L IPO4 FBXW7	2.07e-05	211	27	4	17314511
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	LARP1 ERCC3 CSE1L HECTD1 CEBPZ TOP2B	2.12e-05	759	27	6	35915203
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	CSE1L HECTD1 FBXW7	2.30e-05	71	27	3	29346117
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CHD6 CSE1L CEBPZ SUPT6H TOP2B	2.76e-05	469	27	5	27634302
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	LARP1 FASTKD5 AAMP CSE1L IPO4 HECTD1 CCDC47	3.73e-05	1257	27	7	37317656
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	MAPK8IP2 KIF1B	3.81e-05	12	27	2	16301330
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	LARP1 CSE1L HECTD1 KIF1B	4.34e-05	255	27	4	15324660
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	LARP1 FASTKD5 CHD6 IPO4 CEBPZ CCDC47 TOP2B	5.04e-05	1318	27	7	30463901
Pubmed	Role of topoisomerase IIbeta in the expression of developmentally regulated genes.	MYT1L TOP2B	6.92e-05	16	27	2	16923961
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	LARP1 CSE1L HECTD1 CEBPZ CCDC47 SUPT6H TOP2B	7.88e-05	1415	27	7	28515276
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	LARP1 CSE1L CEBPZ SUPT6H TOP2B	9.21e-05	605	27	5	28977666
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	LARP1 RANBP6 AAMP CSE1L IPO4 HECTD1 KIF1B	9.39e-05	1455	27	7	22863883
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	LARP1 CSE1L IPO4	1.08e-04	119	27	3	35776542
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CHD6 ERCC3 IPO4 TAF1L CEBPZ CCDC47 SUPT6H	1.12e-04	1497	27	7	31527615
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CSE1L IPO4 HECTD1 SUPT6H TOP2B	1.18e-04	638	27	5	33239621
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CRYBG3 CSE1L CEBPZ CCDC47 RCAN3 FBXW7	1.28e-04	1049	27	6	27880917
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	LARP1 AAMP CSE1L IPO4 SUPT6H	1.32e-04	653	27	5	33742100
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	RANBP6 FASTKD5 CLGN CSE1L CCDC47	1.36e-04	657	27	5	36180527
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	LARP1 HECTD1 CEBPZ TOP2B	1.71e-04	364	27	4	24778252
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ERCC3 CSE1L TAF1L CEBPZ	1.82e-04	370	27	4	22922362
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	CSE1L IPO4	1.86e-04	26	27	2	23181366
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	LARP1 CRYBG3 CSE1L CCDC47 KIF1B	1.92e-04	708	27	5	39231216
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	LARP1 FASTKD5 CSE1L IPO4 CCDC47	1.96e-04	711	27	5	33022573
Pubmed	Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.	CSE1L CCDC47	2.01e-04	27	27	2	21343306
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	CSE1L IPO4 HECTD1 TOP2B	2.45e-04	400	27	4	35013556
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	LARP1 FASTKD5 ERCC3 HECTD1 CEBPZ	2.57e-04	754	27	5	33060197
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	RANBP6 CLGN CSE1L CCDC47	2.65e-04	408	27	4	33766124
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	LARP1 ERCC3 CSE1L HECTD1 CEBPZ KIF1B	3.25e-04	1247	27	6	27684187
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	LARP1 AAMP ERCC3 CSE1L IPO4 CEBPZ	3.39e-04	1257	27	6	36526897
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	CSE1L HECTD1 TOP2B	3.64e-04	180	27	3	30110629
Pubmed	A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin.	ERCC3 SUPT6H	3.80e-04	37	27	2	18562274
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	LARP1 CSE1L IPO4 CCDC47	3.80e-04	449	27	4	31732153
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L CHD6 HECTD1 TTLL5 MAPK8IP2 KIF1B	3.82e-04	1285	27	6	35914814
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	LARP1 RANBP6 FBXW7	4.01e-04	186	27	3	33637726
Pubmed	Global landscape of HIV-human protein complexes.	RANBP6 CLGN IPO4 CCDC47	4.06e-04	457	27	4	22190034
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	LARP1 SUPT6H TOP2B	4.13e-04	188	27	3	29721183
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	LARP1 AAMP CLGN CSE1L IPO4 KIF1B	4.42e-04	1321	27	6	27173435
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	LARP1 RANBP6 AAMP CSE1L IPO4 HECTD1	4.68e-04	1335	27	6	29229926
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ERCC3 CSE1L IPO4 CEBPZ CCDC47 TOP2B	5.02e-04	1353	27	6	29467282
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	LARP1 SUPT6H	5.14e-04	43	27	2	34672947
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	HECTD1 MAPK8IP2 FBXW7	7.61e-04	232	27	3	25515538
Interaction	DNAJC21 interactions	AAMP HECTD1 CEBPZ TOP2B FBXW7	1.19e-07	90	27	5	int:DNAJC21
Interaction	FBXW7 interactions	LARP1 CHD6 CSE1L IPO4 HECTD1 CEBPZ CCDC47 SUPT6H TOP2B FBXW7	2.00e-06	1215	27	10	int:FBXW7
Interaction	COIL interactions	FASTKD5 CHD6 IPO4 HECTD1 CEBPZ SUPT6H TOP2B	6.14e-06	552	27	7	int:COIL
Interaction	LMBR1L interactions	RANBP6 FASTKD5 CLGN CSE1L IPO4 HECTD1 CEBPZ CCDC47	2.29e-05	946	27	8	int:LMBR1L
Interaction	RPL31 interactions	LARP1 HECTD1 CEBPZ CCDC47 SUPT6H TOP2B FBXW7	2.38e-05	680	27	7	int:RPL31
Interaction	DPY19L4 interactions	CLGN CCDC47 SLC22A15	2.55e-05	43	27	3	int:DPY19L4
Interaction	POLR1G interactions	FASTKD5 IPO4 HECTD1 CEBPZ SUPT6H TOP2B	3.80e-05	489	27	6	int:POLR1G
Interaction	GTF2H2C interactions	ERCC3 HECTD1 FBXW7	4.03e-05	50	27	3	int:GTF2H2C
Interaction	CHD3 interactions	LARP1 CHD6 CSE1L HECTD1 CEBPZ SUPT6H TOP2B	4.72e-05	757	27	7	int:CHD3
Interaction	CENPA interactions	CHD6 IPO4 CEBPZ CCDC47 TOP2B	1.28e-04	377	27	5	int:CENPA
Interaction	C9orf78 interactions	FASTKD5 AAMP ERCC3 CSE1L IPO4 SUPT6H	1.41e-04	620	27	6	int:C9orf78
Interaction	BAZ1B interactions	HECTD1 SUPT6H TOP2B FBXW7	1.49e-04	204	27	4	int:BAZ1B
Interaction	SIRT6 interactions	LARP1 ERCC3 HECTD1 CEBPZ SUPT6H TOP2B	1.51e-04	628	27	6	int:SIRT6
Interaction	LRRC31 interactions	LARP1 IPO4 HECTD1 TOP2B	1.52e-04	205	27	4	int:LRRC31
Interaction	FBL interactions	LARP1 RANBP6 HECTD1 CEBPZ TOP2B FBXW7	1.66e-04	639	27	6	int:FBL
Interaction	CA9 interactions	CLGN CSE1L IPO4 CCDC47	1.82e-04	215	27	4	int:CA9
Interaction	THOC2 interactions	HECTD1 CCDC47 KIF1B FBXW7	1.96e-04	219	27	4	int:THOC2
Interaction	IPO5 interactions	LARP1 RANBP6 CRYBG3 CSE1L IPO4	1.99e-04	414	27	5	int:IPO5
Interaction	POLR1A interactions	HECTD1 CEBPZ SUPT6H FBXW7	1.99e-04	220	27	4	int:POLR1A
Interaction	PARP1 interactions	RANBP6 CHD6 CSE1L IPO4 HECTD1 CEBPZ SUPT6H TOP2B	2.34e-04	1316	27	8	int:PARP1
Interaction	NIFK interactions	LARP1 HECTD1 CEBPZ TOP2B FBXW7	2.39e-04	431	27	5	int:NIFK
Interaction	HECTD1 interactions	LARP1 ERCC3 CSE1L HECTD1 CEBPZ TOP2B FBXW7	2.43e-04	984	27	7	int:HECTD1
Interaction	GAR1 interactions	HECTD1 CEBPZ TTLL5 FBXW7	2.44e-04	232	27	4	int:GAR1
Interaction	GPATCH4 interactions	HECTD1 CEBPZ TOP2B FBXW7	2.44e-04	232	27	4	int:GPATCH4
Interaction	RPL22 interactions	CSE1L HECTD1 CEBPZ CCDC47 FBXW7	2.63e-04	440	27	5	int:RPL22
Interaction	SUPT16H interactions	AAMP HECTD1 SUPT6H TOP2B FBXW7	2.69e-04	442	27	5	int:SUPT16H
Interaction	ZNF330 interactions	FASTKD5 IPO4 CEBPZ SUPT6H TOP2B	2.80e-04	446	27	5	int:ZNF330
Interaction	SRP19 interactions	LARP1 CCDC47 SUPT6H MAPK8IP2	2.96e-04	244	27	4	int:SRP19
Interaction	SRPK2 interactions	ERCC3 HECTD1 CEBPZ SUPT6H TOP2B FBXW7	3.10e-04	717	27	6	int:SRPK2
Interaction	TCF25 interactions	AAMP HECTD1 FBXW7	3.47e-04	103	27	3	int:TCF25
Interaction	SIRT7 interactions	LARP1 CSE1L IPO4 HECTD1 CEBPZ SUPT6H	3.78e-04	744	27	6	int:SIRT7
Interaction	UBXN7 interactions	RANBP6 ERCC3 CSE1L IPO4	4.16e-04	267	27	4	int:UBXN7
Interaction	STRAP interactions	HECTD1 SUPT6H KIF1B FBXW7	4.34e-04	270	27	4	int:STRAP
Interaction	CCDC59 interactions	RANBP6 HECTD1 CEBPZ	4.43e-04	112	27	3	int:CCDC59
Interaction	XRCC4 interactions	IPO4 HECTD1 FBXW7	4.67e-04	114	27	3	int:XRCC4
Interaction	RTKN interactions	LARP1 KIF1B DNAI2	4.79e-04	115	27	3	int:RTKN
Interaction	WDR5 interactions	LARP1 FASTKD5 CSE1L IPO4 HECTD1 CCDC47 FBXW7	4.82e-04	1101	27	7	int:WDR5
Interaction	FGF13 interactions	LARP1 CEBPZ MAPK8IP2	5.04e-04	117	27	3	int:FGF13
Interaction	CEBPZ interactions	RANBP6 HECTD1 CEBPZ FBXW7	5.04e-04	281	27	4	int:CEBPZ
Interaction	SMS interactions	LARP1 CSE1L MAPK8IP2	5.17e-04	118	27	3	int:SMS
Cytoband	14q12	IPO4 HECTD1	4.85e-04	55	27	2	14q12
Cytoband	Ensembl 112 genes in cytogenetic band chr14q12	IPO4 HECTD1	1.75e-03	105	27	2	chr14q12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q31	CLGN FBXW7	4.20e-03	164	27	2	chr4q31
GeneFamily	WD repeat domain containing	AAMP DNAI2 FBXW7	2.09e-03	262	18	3	362
Drug	platinum	ERCC3 PDCL2 TOP2B MAPK8IP2 FBXW7	2.22e-06	183	27	5	CID000023939
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; HL60; HT_HG-U133A	CLGN CSE1L IPO4 TTLL5 KIF1B	3.43e-06	200	27	5	2988_DN
Drug	carboplatin	TOP2B TTLL5 MAPK8IP2 FBXW7	1.66e-05	131	27	4	CID000038904
Disease	Neuroblastoma	CHD6 KIF1B	7.28e-04	47	25	2	C0027819
Disease	Epstein-Barr virus infection	SLC22A15 MACROD2	1.43e-03	66	25	2	EFO_0000769
Disease	erosive tooth wear measurement	MYT1L MACROD2	2.64e-03	90	25	2	EFO_0009331

Protein segments in the cluster

Peptide	Gene	Start	Entry
MNFDEDDREAADEEE	CRYBG3	2136	Q68DQ2
DDYEDMMEENLEQEE	SLC4A1	6	P02730
DDLAQEMEDVDFEEE	AAMP	41	Q13685
EEYFNDEEAMEVMEE	DNAI2	131	Q9GZS0
QEEEEEMIFGENEDD	RCAN3	21	Q9UKA8
EQEELDFLFDEEMEQ	LARP1	601	Q6PKG0
TELADEQQDEMEDFD	KIF1B	921	O60333
EQQDEMEDFDDEAFV	KIF1B	926	O60333
DDFQEFEMIDDNEEE	MAPK8IP2	76	Q13387
FEMIDDNEEEDDEDE	MAPK8IP2	81	Q13387
DNDFAEFEDVMEDSV	CCDC47	36	Q96A33
EAEDEFDEEDMQAVE	PDCL2	56	Q8N4E4
NEDDNQEDQEYEEVM	HECTD1	1691	Q9ULT8
VDEEDVEVFDSFENM	FASTKD5	101	Q7L8L6
EEEEEEENEEENLAM	CHD6	1866	Q8TD26
EDEEEEEMDQESDDF	FBXW7	111	Q969H0
FYEQMDKDEEEEEET	ERCC3	251	P19447
EEEEEFYDADEETQM	SLC22A15	531	Q8IZD6
EEEEEDDDQAEYDAM	IPO4	816	Q8TEX9
DEENFIDANDDEDME	CEBPZ	631	Q03701
MNEFFSVDDNNEEEE	MACROD2	236	A1Z1Q3
AESDEEEDDVDFAMF	TOP2B	1611	Q02880
EEENEEDFQMKIDDE	TAF1L	931	Q8IZX4
NADEMEEDDFDSNAV	RANBP6	331	O60518
FMDDDVETEDFEENS	CLGN	21	O14967
DQQVEEDDDFMDENQ	SUPT6H	761	Q7KZ85
NMEFRAADEEAFEDN	CSE1L	351	P55060
EEEEEDGVNMENFQE	TTLL5	776	Q6EMB2
EEEEEEENEDHQMNC	MYT1L	161	Q9UL68