Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear export signal receptor activity

NUP214 NUP42

6.25e-0512202GO:0005049
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

NUP153 NUP214

2.82e-0425202GO:0017056
GeneOntologyMolecularFunctionnuclear localization sequence binding

NUP153 NUP214

3.30e-0427202GO:0008139
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

NUP214 NUP42

4.64e-0432202GO:0140142
GeneOntologyMolecularFunctionsignal sequence binding

NUP153 NUP214

1.18e-0351202GO:0005048
GeneOntologyBiologicalProcessRNA localization

PUM2 NUP153 NUP214 MCM3AP NUP42

1.68e-06217205GO:0006403
GeneOntologyBiologicalProcessmRNA transport

NUP153 NUP214 MCM3AP NUP42

1.04e-05145204GO:0051028
GeneOntologyBiologicalProcessRNA transport

NUP153 NUP214 MCM3AP NUP42

2.18e-05175204GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

NUP153 NUP214 MCM3AP NUP42

2.18e-05175204GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

NUP153 NUP214 MCM3AP NUP42

2.33e-05178204GO:0051236
GeneOntologyBiologicalProcessnuclear transport

SPG11 NUP153 NUP214 MCM3AP NUP42

2.49e-05378205GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

SPG11 NUP153 NUP214 MCM3AP NUP42

2.49e-05378205GO:0006913
GeneOntologyBiologicalProcesswalking behavior

HIPK2 SPG11 CHD7

2.58e-0560203GO:0090659
GeneOntologyBiologicalProcessnuclear export

NUP153 NUP214 MCM3AP NUP42

2.71e-05185204GO:0051168
GeneOntologyBiologicalProcessnucleobase-containing compound transport

NUP153 NUP214 MCM3AP NUP42

8.63e-05249204GO:0015931
GeneOntologyBiologicalProcessRNA export from nucleus

NUP153 NUP214 MCM3AP

1.05e-0496203GO:0006405
GeneOntologyBiologicalProcessthyroid gland development

HIPK2 RAP1GAP

4.92e-0434202GO:0030878
GeneOntologyBiologicalProcessregulation of developmental growth

ALMS1 HLX PUM2 CHD7

6.40e-04421204GO:0048638
GeneOntologyBiologicalProcessregulation of growth

ALMS1 HLX PUM2 TRO CHD7

7.24e-04777205GO:0040008
GeneOntologyBiologicalProcessprotein import into nucleus

SPG11 NUP153 NUP214

8.42e-04195203GO:0006606
GeneOntologyBiologicalProcessgrowth

ALMS1 HLX PUM2 TRO SPG11 CHD7

8.52e-041235206GO:0040007
GeneOntologyBiologicalProcessamyloid fibril formation

CDSN NUP153

8.62e-0445202GO:1990000
GeneOntologyBiologicalProcessimport into nucleus

SPG11 NUP153 NUP214

9.20e-04201203GO:0051170
GeneOntologyBiologicalProcessretina development in camera-type eye

ALMS1 HIPK2 CHD7

1.06e-03211203GO:0060041
GeneOntologyBiologicalProcessadult walking behavior

HIPK2 CHD7

1.06e-0350202GO:0007628
GeneOntologyBiologicalProcessdevelopmental growth

ALMS1 HLX PUM2 SPG11 CHD7

1.48e-03911205GO:0048589
GeneOntologyBiologicalProcesspositive regulation of developmental growth

HLX PUM2 CHD7

1.50e-03238203GO:0048639
GeneOntologyBiologicalProcessprotein export from nucleus

NUP214 NUP42

1.79e-0365202GO:0006611
GeneOntologyCellularComponentnuclear pore

NUP153 NUP214 MCM3AP NUP42

2.34e-06101204GO:0005643
GeneOntologyCellularComponentnuclear pore nuclear basket

NUP153 MCM3AP

1.32e-0418202GO:0044615
GeneOntologyCellularComponentnuclear envelope

PUM2 NUP153 NUP214 MCM3AP NUP42

1.50e-04560205GO:0005635
GeneOntologyCellularComponentnuclear membrane

PUM2 NUP153 MCM3AP NUP42

2.99e-04349204GO:0031965
GeneOntologyCellularComponentcytoplasmic stress granule

HIPK2 PUM2

3.76e-0396202GO:0010494
GeneOntologyCellularComponentnuclear protein-containing complex

HIPK2 NUP153 NUP214 MCM3AP NUP42

8.30e-031377205GO:0140513
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

NUP153 NUP214 NUP42

3.80e-0632143M29579
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

NUP153 NUP214 NUP42

4.18e-0633143M27016
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

NUP153 NUP214 NUP42

4.58e-0634143M27041
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP153 NUP214 NUP42

5.01e-0635143M27320
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP153 NUP214 NUP42

5.46e-0636143M26974
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP153 NUP214 NUP42

5.46e-0636143M27245
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

NUP153 NUP214 NUP42

5.94e-0637143M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

NUP153 NUP214 NUP42

5.94e-0637143M27038
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP153 NUP214 NUP42

6.98e-0639143M27238
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP153 NUP214 NUP42

7.54e-0640143MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP153 NUP214 NUP42

8.13e-0641143MM15200
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

NUP153 NUP214 NUP42

8.13e-0641143M29574
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP153 NUP214 NUP42

8.75e-0642143MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP153 NUP214 NUP42

9.40e-0643143MM14609
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP153 NUP214 NUP42

9.40e-0643143M26975
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

NUP153 NUP214 NUP42

1.01e-0544143M109
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP153 NUP214 NUP42

1.15e-0546143M27397
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP153 NUP214 NUP42

1.23e-0547143MM14939
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP153 NUP214 NUP42

1.23e-0547143M27395
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP153 NUP214 NUP42

1.40e-0549143MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP153 NUP214 NUP42

1.49e-0550143MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP153 NUP214 NUP42

1.58e-0551143MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP153 NUP214 NUP42

1.77e-0553143M27212
PathwayREACTOME_SUMOYLATION

HIPK2 NUP153 NUP214 NUP42

1.82e-05169144MM14919
PathwayREACTOME_SNRNP_ASSEMBLY

NUP153 NUP214 NUP42

1.88e-0554143M29594
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP153 NUP214 NUP42

1.98e-0555143MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP153 NUP214 NUP42

2.33e-0558143MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

NUP153 NUP214 NUP42

2.33e-0558143MM14736
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

NUP153 NUP214 NUP42

2.45e-0559143M27606
PathwayREACTOME_SUMOYLATION

HIPK2 NUP153 NUP214 NUP42

2.82e-05189144M27214
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP153 NUP214 NUP42

3.28e-0565143MM15147
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP153 NUP214 NUP42

4.28e-0571143M27394
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP153 NUP214 NUP42

4.65e-0573143MM14948
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

NUP153 NUP214 NUP42

4.85e-0574143M48006
PathwayBIOCARTA_NPC_PATHWAY

NUP153 NUP214

5.01e-0511142M22033
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

NUP153 NUP214 NUP42

5.46e-0577143M27226
PathwayREACTOME_GLUCOSE_METABOLISM

NUP153 NUP214 NUP42

6.59e-0582143MM15394
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP153 NUP214 NUP42

6.59e-0582143M27250
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

NUP153 NUP214 NUP42

7.09e-0584143MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

NUP153 NUP214 NUP42

7.09e-0584143M725
PathwayREACTOME_GLUCOSE_METABOLISM

NUP153 NUP214 NUP42

7.34e-0585143M1870
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

NUP153 NUP214 NUP42

7.60e-0586143MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

NUP153 NUP214 NUP42

9.29e-0592143MM14951
PathwayPID_SMAD2_3PATHWAY

NUP153 NUP214

1.09e-0416142M228
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

NUP153 NUP214 NUP42

1.16e-0499143M27474
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

NUP153 NUP214 NUP42

1.23e-04101143M27253
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP153 NUP214 NUP42

1.42e-04106143M27458
PathwayWP_PRADERWILLI_AND_ANGELMAN_SYNDROME

NUP153 NUP214 NUP42

1.54e-04109143M39542
PathwayREACTOME_TRNA_PROCESSING

NUP153 NUP214 NUP42

1.62e-04111143M27684
PathwayREACTOME_MITOTIC_PROPHASE

NUP153 NUP214 NUP42

1.76e-04114143MM15361
PathwayREACTOME_HCMV_LATE_EVENTS

NUP153 NUP214 NUP42

1.85e-04116143M29806
PathwayREACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES

NUP153 NUP214 NUP42

2.36e-04126143M45009
PathwayREACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

NUP153 NUP214 NUP42

2.65e-04131143M5283
PathwayREACTOME_HCMV_EARLY_EVENTS

NUP153 NUP214 NUP42

3.09e-04138143M29805
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP153 NUP214 NUP42

3.15e-04139143M715
PathwayREACTOME_MITOTIC_PROPHASE

NUP153 NUP214 NUP42

3.36e-04142143M27660
PathwayREACTOME_HIV_LIFE_CYCLE

NUP153 NUP214 NUP42

3.87e-04149143M4076
PathwayREACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES

NUP153 NUP214 NUP42

4.02e-04151143M550
PathwayREACTOME_M_PHASE

ALMS1 NUP153 NUP214 NUP42

4.50e-04387144MM15364
PathwayREACTOME_INFLUENZA_INFECTION

NUP153 NUP214 NUP42

4.51e-04157143M4669
PathwayREACTOME_HCMV_INFECTION

NUP153 NUP214 NUP42

4.94e-04162143M29804
PathwayREACTOME_M_PHASE

ALMS1 NUP153 NUP214 NUP42

5.97e-04417144M27662
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

NUP153 NUP214 NUP42

6.40e-04177143M27476
PathwayREACTOME_SARS_COV_2_HOST_INTERACTIONS

NUP153 NUP214 NUP42

9.66e-04204143M45011
PathwayREACTOME_HIV_INFECTION

NUP153 NUP214 NUP42

1.38e-03231143M12469
PathwayREACTOME_CELL_CYCLE_MITOTIC

ALMS1 NUP153 NUP214 NUP42

1.81e-03561144M5336
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

HIPK2 PUM2 MUC6 NUP153 NUP214 NUP42

1.86e-031475146M19806
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

NUP153 NUP214 NUP42

2.19e-03271143MM15406
PathwayREACTOME_INTERFERON_SIGNALING

NUP153 NUP214 NUP42

2.23e-03273143M983
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

NUP153 NUP214 NUP42

2.33e-03277143MM15414
PathwayREACTOME_CELL_CYCLE

ALMS1 NUP153 NUP214 NUP42

2.35e-03603144MM14635
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

NUP153 NUP214 NUP42

2.47e-03283143M13087
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

NUP153 NUP214 NUP42

2.60e-03288143M16864
PathwayREACTOME_SARS_COV_2_INFECTION

NUP153 NUP214 NUP42

2.89e-03299143M41727
PathwayREACTOME_CELL_CYCLE

ALMS1 NUP153 NUP214 NUP42

3.92e-03694144M543
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

HIPK2 MUC6 NUP153 NUP214 NUP42

8.64e-031389145MM15307
PathwayREACTOME_SARS_COV_INFECTIONS

NUP153 NUP214 NUP42

1.02e-02471143M39009
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

NUP153 NUP214 NUP42

1.24e-02505143MM15548
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

HIPK2 NUP153 NUP214 NUP42

1.53e-021022144MM15436
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

NUP153 NUP214 MCM3AP NUP42

1.05e-077720424927568
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

NUP153 NUP214 NUP42

3.71e-072520310601273
Pubmed

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

NUP153 NUP214 NUP42

4.19e-072620312228227
Pubmed

The Structure Inventory of the Nuclear Pore Complex.

NUP153 NUP214 NUP42

6.54e-073020327016207
Pubmed

Integrated structural analysis of the human nuclear pore complex scaffold.

NUP153 NUP214 NUP42

6.54e-073020324315095
Pubmed

The nuclear pore complex: a new dynamic in HIV-1 replication.

NUP153 NUP214

9.42e-07320221327100
Pubmed

Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev.

NUP153 NUP214

9.42e-0732029847314
Pubmed

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.

NUP153 NUP214

9.42e-07320212191473
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

NUP153 NUP214 NUP42

1.35e-063820312791264
Pubmed

A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.

NUP214 NUP42

1.88e-06420210358091
Pubmed

Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.

NUP153 NUP214

3.14e-06520212138183
Pubmed

A giant nucleopore protein that binds Ran/TC4.

NUP153 NUP214

3.14e-0652027603572
Pubmed

Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.

NUP153 NUP214

3.14e-06520212917407
Pubmed

Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.

NUP153 NUP214

3.14e-06520211777942
Pubmed

The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase.

NUP153 NUP214

3.14e-06520216730000
Pubmed

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.

NUP214 NUP42

4.71e-06620210228171
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

PUM2 NUP153 NUP214 MCM3AP NUP42

5.05e-0645720532344865
Pubmed

Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.

NUP153 NUP214

6.59e-06720211238447
Pubmed

A human MAP kinase interactome.

HIPK2 NUP153 NUP214 MCM3AP NUP42

6.81e-0648620520936779
Pubmed

Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.

NUP153 NUP214

8.78e-06820231375530
Pubmed

TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation.

NUP153 NUP214

8.78e-06820220123736
Pubmed

Cloning and characterization of human karyopherin beta3.

NUP153 NUP214

1.13e-0592029114010
Pubmed

The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.

NUP153 NUP214

1.41e-051020218596238
Pubmed

Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.

NUP153 NUP214

1.41e-051020219581287
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ALMS1 HIPK2 CHD7 MCM3AP NUP42

1.71e-0558820538580884
Pubmed

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

NUP153 MCM3AP

1.72e-051120223652018
Pubmed

Vpr-host interactions during HIV-1 viral life cycle.

NUP153 NUP42

2.44e-051320221318276
Pubmed

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.

NUP153 NUP214

2.85e-051420211073998
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

NUP153 NUP214

3.28e-051520214697343
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

NUP153 NUP214

4.25e-051720210668806
Pubmed

Interaction network of human early embryonic transcription factors.

ALMS1 CHD7 NUP214 MCM3AP

4.35e-0535120438297188
Pubmed

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.

NUP153 NUP214 MCM3AP

4.48e-0512120322412018
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

NUP153 NUP214 NUP42

4.71e-0512320326912792
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ALMS1 PUM2 SPG11 CHD7 NUP214

4.89e-0573320534672954
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

ALMS1 PUM2 MCM3AP

5.55e-0513020312421765
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PUM2 TRO NUP214 MCM3AP

7.72e-0540720412693553
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRO NUP153 CHD7 NUP214

9.54e-0543020435044719
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

PUM2 NUP153 NUP214 MCM3AP

9.63e-0543120433660365
Pubmed

BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.

NUP153 NUP214

1.45e-043120223086144
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

NUP153 MCM3AP NUP42

1.46e-0418020335198878
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

NUP153 CHD7 NUP214

1.74e-0419120331177093
Pubmed

Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.

NUP153 NUP214

1.74e-043420218539113
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

NUP153 NUP214

2.42e-044020237516964
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ALMS1 PUM2 CHD7

2.81e-0422520312168954
Pubmed

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.

ALMS1 NUP214

3.64e-044920231762063
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

NUP153 NUP214 NUP42

3.82e-0425020333536335
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

ALMS1 NUP153 NUP42

4.43e-0426320334702444
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NUP153 CHD7 NUP214 MCM3AP

4.70e-0465320422586326
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

PUM2 NUP153 NUP214 MCM3AP

4.75e-0465520435819319
InteractionNXF2 interactions

TRO NUP153 NUP214 NUP42

4.59e-0765204int:NXF2
InteractionNUP42 interactions

PUM2 NUP153 NUP214 NUP42

1.27e-05149204int:NUP42
InteractionDPPA3 interactions

ALMS1 NUP214 MCM3AP

3.84e-0567203int:DPPA3
InteractionNUP35 interactions

PUM2 NUP153 NUP214 MCM3AP NUP42

4.81e-05424205int:NUP35
InteractionNUP155 interactions

ALMS1 NUP153 NUP214 MCM3AP NUP42

8.40e-05477205int:NUP155
InteractionDTX2 interactions

HLX NUP153 MCM3AP NUP42

2.78e-04330204int:DTX2
InteractionZHX1-C8orf76 interactions

ALMS1 SPG11

3.00e-0426202int:ZHX1-C8orf76
InteractionNUP50 interactions

NUP153 CHD7 NUP214 MCM3AP

3.15e-04341204int:NUP50
GeneFamilyNucleoporins

NUP153 NUP214

1.65e-04321121051
Diseasegastric ulcer (implicated_via_orthology)

PTGER1 MUC6

3.95e-0514202DOID:10808 (implicated_via_orthology)
Diseasepancreatic cancer (is_marker_for)

MUC6 RAP1GAP

2.12e-03101202DOID:1793 (is_marker_for)
DiseaseHypermetropia

ALMS1 CHD7

2.20e-03103202HP_0000540
Diseaseneutrophil measurement

NUP153 CHD7

6.33e-03177202EFO_0803548
DiseaseHypermetropia, Myopia

TCP11L2 CHD7

7.19e-03189202HP_0000540, HP_0000545

Protein segments in the cluster

PeptideGeneStartEntry
SLASSSVAKSHSFFS

AMER2

151

Q8N7J2
ETSSKTFSFLTSFSF

ADGRG4

551

Q8IZF6
SSSASSFLSSNSTFC

ALMS1

3861

Q8TCU4
SSSHSSSSSSFQFSS

CDSN

151

Q15517
SSSSSFQFSSSSFQV

CDSN

156

Q15517
ATSSTSNFSSLSSKF

CHD7

2451

Q9P2D1
ASSTSSLFSSSSQLF

PUM2

676

Q8TB72
SSFSTATASSSFISS

MUC6

2076

Q6W4X9
SSYKSKSSSNVTSTS

HIPK2

996

Q9H2X6
GNSFSFSSASSLSSS

HLX

431

Q14774
QVTSSSATTSNFTFS

MCM3AP

196

O60318
ASASSASSIASASTF

PTGER1

261

P34995
VFGAASSTSSSSSFS

NUP214

1771

P35658
SSTSSSSSFSFGQSS

NUP214

1776

P35658
TSAASFSFKSPAASS

NUP42

296

O15504
AKFSTSSSDQSFASF

CEFIP

726

Q711Q0
SRQSFASDSSSKSSS

TCP11L2

36

Q8N4U5
ALKDFSRSSSSASSF

RAP1GAP

561

P47736
ASSFAENFSTSSSSF

CMTM8

16

Q8IZV2
NSISSKAASSFFSTQ

SPG11

1741

Q96JI7
LSTSSSFSSAASISF

TRO

781

Q12816
KGFDTSSSSSNSAAS

NUP153

886

P49790
SSSSSNSAASSSFKF

NUP153

891

P49790
NSAASSSFKFGVSSS

NUP153

896

P49790
TNFSSAFSSDSKSSS

VSIG10L

31

Q86VR7