Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.09e-04	4	86	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.09e-04	4	86	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.09e-04	4	86	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.09e-04	4	86	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	2.72e-04	6	86	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	2.72e-04	6	86	2	GO:0062186
GeneOntologyMolecularFunction	U3 snoRNA binding	TSR1 PRKDC	9.83e-04	11	86	2	GO:0034511
Domain	N_BRCA1_IG	ILRUN NBR1	2.05e-05	2	85	2	PF16158
Domain	N_BRCA1_central	ILRUN NBR1	2.05e-05	2	85	2	IPR032350
Domain	LamGL	PAPPA2 USH2A	1.22e-04	4	85	2	SM00560
Domain	LamG-like	PAPPA2 USH2A	1.22e-04	4	85	2	IPR006558
Domain	NUT	NUTM2B NUTM2A	2.03e-04	5	85	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	2.03e-04	5	85	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	2.03e-04	5	85	2	PF12881
Domain	TIL	MUC2 OTOG	1.31e-03	12	85	2	PF01826
Domain	C8	MUC2 OTOG	1.31e-03	12	85	2	PF08742
Domain	SANT	RCOR1 ZSCAN20 RCOR3	1.53e-03	50	85	3	SM00717
Domain	Unchr_dom_Cys-rich	MUC2 OTOG	1.55e-03	13	85	2	IPR014853
Domain	ELM2	RCOR1 RCOR3	1.55e-03	13	85	2	PF01448
Domain	C8	MUC2 OTOG	1.55e-03	13	85	2	SM00832
Domain	ELM2	RCOR1 RCOR3	1.55e-03	13	85	2	PS51156
Domain	ELM2_dom	RCOR1 RCOR3	1.55e-03	13	85	2	IPR000949
Domain	ELM2	RCOR1 RCOR3	1.55e-03	13	85	2	SM01189
Domain	SANT/Myb	RCOR1 ZSCAN20 RCOR3	1.71e-03	52	85	3	IPR001005
Domain	TIL_dom	MUC2 OTOG	1.80e-03	14	85	2	IPR002919
Domain	VWD	MUC2 OTOG	2.36e-03	16	85	2	SM00216
Domain	VWF_type-D	MUC2 OTOG	2.36e-03	16	85	2	IPR001846
Domain	VWFD	MUC2 OTOG	2.36e-03	16	85	2	PS51233
Domain	VWD	MUC2 OTOG	2.36e-03	16	85	2	PF00094
Domain	FN3_dom	PAPPA2 IGFN1 IL20RA DCC USH2A	2.66e-03	209	85	5	IPR003961
Domain	PH_dom-like	RTKN2 RASA1 CADPS APBB2 PLCB3 EPS8L3 NSMAF	3.27e-03	426	85	7	IPR011993
Domain	VWC_out	MUC2 OTOG	3.33e-03	19	85	2	SM00215
Domain	CT	MUC2 OTOG	4.46e-03	22	85	2	SM00041
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RCOR1 TSR1 SUPT5H UBR4 STON2 RCOR3 PRKDC ATP2B1 PPP6R3	8.09e-07	399	88	9	37536630
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RC3H2 RASA1 TFB1M MAP1B SND1 TSR1 BOP1 PRKDC TP53 PPP6R3	1.28e-06	547	88	10	37267103
Pubmed	p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.	RASA1 DCC	6.33e-06	2	88	2	26710849
Pubmed	Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response.	PRKDC TP53	6.33e-06	2	88	2	28177883
Pubmed	Mutations in the p53 and scid genes do not cooperate in lymphomagenesis in doubly heterozygous mice.	PRKDC TP53	6.33e-06	2	88	2	10082662
Pubmed	Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.	MAP1B TP53	6.33e-06	2	88	2	18656471
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	6.33e-06	2	88	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	6.33e-06	2	88	2	11207030
Pubmed	BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.	PRKDC TP53	6.33e-06	2	88	2	12750252
Pubmed	The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse.	PRKG1 TP53	6.33e-06	2	88	2	19955367
Pubmed	p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.	PRKDC TP53	6.33e-06	2	88	2	8598286
Pubmed	Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.	PRKDC TP53	6.33e-06	2	88	2	15792956
Pubmed	Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.	PRKDC TP53	6.33e-06	2	88	2	15753354
Pubmed	IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.	PRKDC TP53	6.33e-06	2	88	2	11970883
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	6.33e-06	2	88	2	3123997
Pubmed	New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.	TP53 PTP4A1	6.33e-06	2	88	2	18997816
Pubmed	UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53.	UBE2Q1 TP53	6.33e-06	2	88	2	25987028
Pubmed	MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network.	MAP1B NBR1	6.33e-06	2	88	2	22654911
Pubmed	DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.	PRKDC TP53	6.33e-06	2	88	2	9679979
Pubmed	Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.	PRKDC TP53	6.33e-06	2	88	2	15355354
Pubmed	DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.	PRKDC TP53	6.33e-06	2	88	2	12065413
Pubmed	DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan.	PRKDC TP53	6.33e-06	2	88	2	27693638
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	6.33e-06	2	88	2	11032406
Pubmed	BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation.	BOP1 TP53	6.33e-06	2	88	2	33877544
Pubmed	p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice.	PRKDC TP53	6.33e-06	2	88	2	9006086
Pubmed	Phosphorylation by DNAPK inhibits the DNA-binding function of p53/T antigen complex in vitro.	PRKDC TP53	6.33e-06	2	88	2	10470151
Pubmed	Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.	RASA1 TP53	6.33e-06	2	88	2	18024870
Pubmed	L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.	PRKDC MUC2	6.33e-06	2	88	2	36584066
Pubmed	Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.	PRKDC TP53	6.33e-06	2	88	2	20204287
Pubmed	p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest.	PRKDC TP53	6.33e-06	2	88	2	22198295
Pubmed	Transcriptional activation of the MUC2 gene by p53.	MUC2 TP53	6.33e-06	2	88	2	12374798
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	6.33e-06	2	88	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	6.33e-06	2	88	2	26297049
Pubmed	Mutations in the p53 and SCID genes cooperate in tumorigenesis.	PRKDC TP53	6.33e-06	2	88	2	8769648
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	6.33e-06	2	88	2	15051713
Pubmed	BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.	BOP1 TP53	6.33e-06	2	88	2	33510838
Pubmed	Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis.	PRKDC TP53	6.33e-06	2	88	2	21833014
Pubmed	Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer.	DCC TP53	6.33e-06	2	88	2	11518545
Pubmed	Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.	DCC TP53	6.33e-06	2	88	2	22358843
Pubmed	DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?	PRKDC TP53	1.90e-05	3	88	2	19136475
Pubmed	Dysfunctional mammalian telomeres join with DNA double-strand breaks.	PRKDC TP53	1.90e-05	3	88	2	15010310
Pubmed	Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells.	PRKDC TP53	1.90e-05	3	88	2	19918261
Pubmed	DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.	PRKDC TP53	1.90e-05	3	88	2	9679063
Pubmed	Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.	PRKDC TP53	1.90e-05	3	88	2	25362358
Pubmed	Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.	ANPEP SLC6A19	1.90e-05	3	88	2	22677001
Pubmed	p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl11b-/- mice.	PRKDC TP53	1.90e-05	3	88	2	15694382
Pubmed	Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.	PRKDC TP53	1.90e-05	3	88	2	27629740
Pubmed	DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.	PRKDC TP53	1.90e-05	3	88	2	14752107
Pubmed	Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.	PRKDC TP53	1.90e-05	3	88	2	11751391
Pubmed	The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.	RASA1 TP53	1.90e-05	3	88	2	11751853
Pubmed	The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.	PRKDC TP53	1.90e-05	3	88	2	8943020
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	1.90e-05	3	88	2	26542179
Pubmed	The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.	PRKDC TP53	1.90e-05	3	88	2	10677503
Pubmed	The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.	PRKDC TP53	1.90e-05	3	88	2	21397859
Pubmed	The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.	PRKDC TP53	1.90e-05	3	88	2	12559174
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	1.90e-05	3	88	2	22456610
Pubmed	A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.	RASA1 TP53	1.90e-05	3	88	2	28108518
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	1.90e-05	3	88	2	2574001
Pubmed	HIV integration and T cell death: additional commentary.	PRKDC TP53	1.90e-05	3	88	2	24321564
Pubmed	Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.	PRKDC TP53	1.90e-05	3	88	2	29084207
Pubmed	DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.	PRKDC TP53	1.90e-05	3	88	2	9363941
Pubmed	Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70.	PRKDC TP53	1.90e-05	3	88	2	8940078
Pubmed	HIV: Integration triggers death.	PRKDC TP53	1.90e-05	3	88	2	23739334
Pubmed	HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.	PRKDC TP53	1.90e-05	3	88	2	23739328
Pubmed	p53 deficiency does not affect mutation rate in the mouse germline.	PRKDC TP53	1.90e-05	3	88	2	15806156
Pubmed	Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53: Experimental and Molecular Modeling Study.	UBE2Q1 TP53	1.90e-05	3	88	2	37198983
Pubmed	Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.	PRKDC TP53	1.90e-05	3	88	2	30072430
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	1.90e-05	3	88	2	24220028
Pubmed	V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.	PRKDC TP53	1.90e-05	3	88	2	8769647
Pubmed	B cell acute lymphoblastic leukemia cells mediate RANK-RANKL-dependent bone destruction.	PRKDC TP53	1.90e-05	3	88	2	32938796
Pubmed	Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.	PLCB3 PRKG1	1.90e-05	3	88	2	11278298
Pubmed	Asymmetry-defective oligodendrocyte progenitors are glioma precursors.	PRKDC TP53	1.90e-05	3	88	2	21907924
Pubmed	Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.	PRKDC TP53	1.90e-05	3	88	2	28686579
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	1.90e-05	3	88	2	1978251
Pubmed	Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.	PRKDC TP53	3.79e-05	4	88	2	21042724
Pubmed	Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes.	RASA1 TP53	3.79e-05	4	88	2	11246230
Pubmed	ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.	PRKDC TP53	3.79e-05	4	88	2	37345534
Pubmed	p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.	PRKDC TP53	3.79e-05	4	88	2	18505846
Pubmed	Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.	PRKDC TP53	3.79e-05	4	88	2	10435582
Pubmed	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.	PRKDC TP53	3.79e-05	4	88	2	19058849
Pubmed	DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.	PRKDC TP53	3.79e-05	4	88	2	17145779
Pubmed	Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.	DCC TP53	3.79e-05	4	88	2	19543899
Pubmed	BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.	BTNL9 TP53	3.79e-05	4	88	2	33756341
Pubmed	MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.	PRKDC TP53	3.79e-05	4	88	2	24888589
Pubmed	p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.	PRKDC TP53	3.79e-05	4	88	2	34192538
Pubmed	Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.	PRKDC TP53	3.79e-05	4	88	2	35537038
Pubmed	Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.	PRKDC TP53	3.79e-05	4	88	2	34388391
Pubmed	Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.	PRKDC TP53	3.79e-05	4	88	2	19450527
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MAP1B SND1 TSR1 SUPT5H UBR4 BOP1 PRKDC TP53 PPP6R3	4.19e-05	653	88	9	22586326
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MAP1B RNF213 PRKDC DMXL1	4.27e-05	76	88	4	27542412
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	RC3H2 RBSN RCOR1 BOP1 RCOR3 WASHC2A	4.40e-05	251	88	6	29778605
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	STOX2 TSR1 STARD9 UBR4 RCOR3	4.50e-05	153	88	5	10718198
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	MAP1B CADPS STARD9 AP3B2 RCOR3 PRKDC IGSF1 NSMAF	4.85e-05	513	88	8	25798074
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	RBSN SND1 TSR1 ECD ATP2B1	5.74e-05	161	88	5	32572027
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GBA3 SND1 CACNA2D2 TSR1 SUPT5H STARD9 UBR4 BOP1 PRKDC PPAT ATP2B1 NBR1 TP53	5.97e-05	1425	88	13	30948266
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TUBGCP6 STOX2 FLYWCH1 TSR1 BOP1 IGSF1 NBR1 PPP6R3	6.02e-05	529	88	8	14621295
Pubmed	Polymorphisms of DNA repair genes and risk of glioma.	PRKDC TP53	6.30e-05	5	88	2	15313891
Pubmed	TXNIP interacts with hEcd to increase p53 stability and activity.	ECD TP53	6.30e-05	5	88	2	23880345
Pubmed	Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.	PRKDC TP53	6.30e-05	5	88	2	15647757
Pubmed	Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells.	PRKDC TP53	6.30e-05	5	88	2	22430210
Cytoband	10q22.3	NUTM2E NUTM2B ECD	7.94e-05	43	88	3	10q22.3
Cytoband	15q15.2	STARD9 TGM7	4.28e-04	16	88	2	15q15.2
Cytoband	3p14.2	CFAP20DC CADPS	4.85e-04	17	88	2	3p14.2
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	7.45e-04	21	88	2	Xp22.11
Cytoband	4p15.2	GBA3 SLC34A2	1.33e-03	28	88	2	4p15.2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RCOR1 ZSCAN20 RCOR3	4.23e-04	53	50	3	532
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 IGFN1 DPY19L2 COL26A1 MAP1B APBB2 PRKG1	8.50e-08	185	88	7	35d39a1d04c871edcfb749653538dc5fd0054281
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RC3H2 RBSN SND1 EXPH5 FHIP2A NSMAF	1.37e-06	176	88	6	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 DLGAP2 MAP1B CADPS AP3B2 SLC6A19	1.77e-06	184	88	6	3da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RTKN2 STOX2 CACNA2D2 EXPH5 SLC34A2 PRKG1	2.48e-06	195	88	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPY19L2 CACNA2D2 EXPH5 APBB2 KNG1	1.75e-05	162	88	5	36ddebe3bb172c992739353b7b049b2dde98b559
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 DLGAP2 CFAP20DC TFB1M IL20RA	2.40e-05	173	88	5	506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANPEP TMPRSS4 EPS8L3 IGSF1 KNG1	2.61e-05	176	88	5	24eedbbb406d788630bb16678cceef4492d3999c
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	RTKN2 STOX2 EXPH5 APBB2 SLC34A2	2.83e-05	179	88	5	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B CADPS AP3B2 SLC6A19 PRKG1	2.90e-05	180	88	5	9db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ANPEP MAP1B AP3B2 SLC6A19	3.06e-05	182	88	5	398ce074a04f6482470b488f1affae4af7d2ec58
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 MAP1B AP3B2 SLC6A19 IL20RA	3.31e-05	185	88	5	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 MAP1B PRKG1 EPDR1 DCC	3.40e-05	186	88	5	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	RTKN2 STOX2 CACNA2D2 EXPH5 SLC34A2	3.57e-05	188	88	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	3.76e-05	190	88	5	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B CADPS EXPH5 AP3B2 TMPRSS4	3.85e-05	191	88	5	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CMTR1 FLYWCH1 MAP1B CACNA2D2 CADPS	3.85e-05	191	88	5	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CMTR1 FLYWCH1 MAP1B CACNA2D2 CADPS	3.85e-05	191	88	5	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 RTKN2 TROAP EXPH5 TMPRSS4	3.95e-05	192	88	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	Control-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	3.95e-05	192	88	5	f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS EXPH5 AP3B2 TMPRSS4 USH2A	3.95e-05	192	88	5	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	STOX2 CACNA2D2 EXPH5 SLC34A2 PRKG1	3.95e-05	192	88	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.05e-05	193	88	5	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	COPD-Endothelial-Lymphatic\|COPD / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.05e-05	193	88	5	18bcf08068a236c4575c7a07181ac893dfdcbeeb
ToppCell	Control-Endothelial-Lymphatic\|Control / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.05e-05	193	88	5	64d19be73e5432d491436a01da5de5c926b615a9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 STOX2 DCDC1 TMPRSS4 RNF213	4.15e-05	194	88	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RTKN2 STOX2 CACNA2D2 SLC34A2 PRKG1	4.15e-05	194	88	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.25e-05	195	88	5	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.25e-05	195	88	5	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPY19L2 CACNA2D2 EXPH5 PRKG1 KNG1	4.25e-05	195	88	5	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.36e-05	196	88	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Control-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DLGAP2 STOX2 MAP1B STON2 PRKG1	4.36e-05	196	88	5	e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.57e-05	198	88	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.57e-05	198	88	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.57e-05	198	88	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.57e-05	198	88	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.57e-05	198	88	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	ASK428-Epithelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	RTKN2 CACNA2D2 EXPH5 SLC34A2 PTP4A1	4.68e-05	199	88	5	ba2aaaeb4d9b448a6b9660b152fcac1a0e3fcfe7
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DOCK3 FLYWCH1 MAP1B CADPS AP3B2	4.68e-05	199	88	5	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	DLGAP2 KIAA1549L MAP1B CADPS ATP2B1	4.79e-05	200	88	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	(05)_Ciliated-(2)_48hpi\|(05)_Ciliated / shred by cell type and Timepoint	COL26A1 SLC34A2 TMPRSS4 OTOG	1.07e-04	124	88	4	fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ZSCAN20 FBXO10 DCDC1 CACNA2D2	1.18e-04	127	88	4	9071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLGAP2 COL26A1 DCC USH2A	1.21e-04	128	88	4	91072ca56bce2c552a95edd67e17f43d8cc1de95
Disease	solanidine measurement	CYP2D7 CYP2D6	5.02e-05	4	86	2	EFO_0800966
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	8.35e-05	5	86	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.25e-04	6	86	2	C0334488
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	EXPH5 TP53	3.72e-04	10	86	2	EFO_1000650, HP_0000131
Disease	basal cell carcinoma (is_implicated_in)	RASA1 TP53	5.44e-04	12	86	2	DOID:2513 (is_implicated_in)
Disease	melanoma	UBR4 MAGEC1 DCC FHIP2A TP53	8.06e-04	248	86	5	C0025202
Disease	pre-malignant neoplasm (biomarker_via_orthology)	MUC2 TP53	1.11e-03	17	86	2	DOID:0060071 (biomarker_via_orthology)
Disease	ischemia (biomarker_via_orthology)	MUC2 TP53	1.25e-03	18	86	2	DOID:326 (biomarker_via_orthology)
Disease	metabolite measurement	TUBGCP6 GBA3 CYP2D7 CYP2D6 DCC KNG1 PPP6R3	1.26e-03	560	86	7	EFO_0004725
Disease	hippocampal tail volume	STOX2 ITPRID1	1.39e-03	19	86	2	EFO_0009398
Disease	alpha-tocopherol measurement	CFAP20DC USH2A	1.54e-03	20	86	2	EFO_0007898
Disease	age at voice drop	CACNA2D2 IGSF1	1.87e-03	22	86	2	EFO_0007888
Disease	thalamus volume	ILRUN DCDC1 OAS2	1.99e-03	85	86	3	EFO_0006935
Disease	alcohol dependence	CLGN EPS8L3 DCC MUC2	2.05e-03	183	86	4	MONDO_0007079
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	2.22e-03	24	86	2	EFO_0003761, EFO_0005658
Disease	Bradycardia	CYP2D6 KNG1	2.61e-03	26	86	2	C0428977
Disease	Adenocarcinoma of large intestine	PRKDC DCC TP53	2.81e-03	96	86	3	C1319315
Disease	Colorectal cancer	DCC TP53	2.81e-03	27	86	2	cv:C0346629
Disease	COLORECTAL CANCER	DCC TP53	2.81e-03	27	86	2	114500
Disease	Neoplasm of the large intestine	DCC TP53	2.81e-03	27	86	2	cv:C0009404
Disease	Sezary Syndrome	PRKG1 TP53	2.81e-03	27	86	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
PNPDDPLANDVVEQW	UBE2NL	116	Q5JXB2
PTPSFYDLWAQEDPN	BOP1	276	Q14137
PWDPLDIPQNSTFED	EPDR1	121	Q9UM22
NDSDTWLQPYEPADP	BTNL9	516	Q6UXG8
SPTPENEKQPWSDFA	APBB2	341	Q92870
PNKAAEDWTENPEPF	CACNA2D2	771	Q9NY47
PNQPDVEPESWREAF	FBXO10	61	Q9UK96
PAEEDLDPQYSWSPT	DLGAP2	51	Q9P1A6
TPLPEDPNWNVTEFH	ANPEP	256	P15144
LDEALTPNTSPAQWP	DMXL1	2281	Q9Y485
NLPPEDDDQWLDLSP	ECD	406	O95905
PAGEPEPEWDNENDI	ATP2B1	656	P20020
TGYQELPDWPEEAPD	AP3B2	636	Q13367
DPNPDAVSPTWEQLE	RC3H2	361	Q9HBD1
SLADLPNFTPFPDEW	RCOR1	181	Q9UKL0
PNFTPFPDEWTVEDK	RCOR1	186	Q9UKL0
LADLPNFTPFPDEWT	RCOR3	76	Q9P2K3
VVPWVNDQDVPFCPD	RBSN	151	Q9H1K0
PVWSEEFVFDDLPPD	RASA1	636	P20936
ALEVQPPDTWDSFPL	CADPS	936	Q9ULU8
PPDTWDSFPLFQLLN	CADPS	941	Q9ULU8
PPSNWYTAETPENDL	DCC	706	P43146
PVLPSGQLNEEFDWP	DCDC1	896	M0R2J8
ELSPSFINPNPLEWF	MAP1B	2096	P46821
FINPNPLEWFASEEP	MAP1B	2101	P46821
EWEDSLSPLHFPQFP	MAGEC1	716	O60732
EWLPPDPEEESQSLT	ITPRID1	36	Q6ZRS4
EHFPNLAQWDSPDPL	FLYWCH1	581	Q4VC44
NDEPPPDDNSGWDID	PRKG1	656	Q13976
ECPDFDPPRQENETW	MUC2	4411	Q02817
PTFSDDWQLPEPSSQ	EPS8L3	386	Q8TE67
PPPWDASLLENEFFQ	EXPH5	196	Q8NEV8
DTEDLSPNWPLNSQE	TUBGCP6	1376	Q96RT7
ENELPSQWADSVPLP	KIAA1549L	1746	Q6ZVL6
SPDDIEQWFTEDPGP	TP53	46	P04637
EQWFTEDPGPDEAPR	TP53	51	P04637
EIWDVEDPSNAANPP	DPY19L2	716	Q6NUT2
SPNLDNELPAPSWNV	OAS2	321	P29728
PEEEPSTTLVDWDPQ	IL20RA	471	Q9UHF4
LSWYPPDVNDENGEP	MANEA	186	Q5SRI9
SFNPVWDEEPFDFPK	PLCB3	771	Q01970
DQPCEPSLQAWSPEV	PAPPA2	921	Q9BXP8
APDTWAPAPDQTEQD	ILRUN	246	Q9H6K1
QAYPDIWSEPSDPLE	IGSF1	1231	Q8N6C5
AWNADEDLEPPYLPV	DOCK3	1921	Q8IZD9
FPQSDPAPLDDTQRW	GBA3	376	Q9H227
TWDPAQPPRDLTEAF	CYP2D6	261	P10635
DVELPPWASSPEDFL	NSMAF	476	Q92636
ISPAPIQSDDDWIPD	KNG1	576	P01042
WEPSPDEAQDVPLHY	IGFN1	1061	Q86VF2
PENTLPNQEWLSSSP	FHIP2A	536	Q5W0V3
PWDVALAPNPEFEAF	SBK3	241	P0C264
STPPTWNEDFLPDAI	COL26A1	171	Q96A83
EPEPSACEQVSWFPE	CMTR1	146	Q8N1G2
AEDPAPFLDSWQVPS	OTOG	2271	Q6ZRI0
QEEDWTPPDPGLLSY	NUTM2A	551	Q8IVF1
QEEDWTPPDPGLLSY	NUTM2B	551	A6NNL0
QEEDWTPPDPGLLSY	NUTM2E	551	B1AL46
DQEYVSPDWAAAPEP	GAREM2	406	Q75VX8
SEWQEPVLEPFDPFE	GAREM2	691	Q75VX8
QHEESLPPPWATLFD	RTKN2	461	Q8IZC4
QPLWTDEAPPDSQLA	USH2A	4146	O75445
EPLPWSDCPLNENQT	SLC6A19	146	Q695T7
ADPQLPVWPAQEVED	SUPT20HL1	321	Q3ZLR7
ENWSYNESCPPDPAE	TMEM150A	36	Q86TG1
CDTDQPQDKPPDWFT	NBR1	141	Q14596
TQPDAKDTPDEPWAF	SND1	66	Q7KZF4
FSESLKRPWEDDPPN	TFB1M	121	Q8WVM0
WDPNNPNTPSRAEEE	SUPT5H	821	O00267
PEERKWDFPEPENSE	STARD9	1126	Q9P2P6
PNTETDREPWDPVQA	STARD9	2651	Q9P2P6
HQSEWVSFNEEPPFP	STON2	11	Q8WXE9
ADPQLPVWPAQEVED	SUPT20HL2	321	P0C7V6
LGPQSPDQSDEWIFP	CFAP20DC	286	Q6ZVT6
FIPDPNAEKPDDWNE	CLGN	321	O14967
PVTLSFWEPEEPNNI	CLEC17A	331	Q6ZS10
SWEQTLPDGLSQPDP	C11orf53	106	Q8IXP5
TWDPAQPPRDLTEAF	CYP2D7	261	A0A087X1C5
DEPTEVDDPWNLPTL	SLC34A2	61	O95436
PCLFPGSDSWQENPE	RNF213	61	Q63HN8
TSPWDPKENLPQDYA	TSR1	511	Q2NL82
EAQSFQLQPVDPWPE	ZSCAN20	156	P17040
FSAQFPPEEWPLRDE	STOX2	286	Q9P2F5
SDFQPPDFRDLPEWE	SOGA1	531	O94964
YPDPSQWTDEELGIP	NDUFB2	86	O95178
AYTPPQEQDDTPDWV	PPAT	156	Q06203
LPFFDEELTPATPLW	TMPRSS4	311	Q9NRS4
SPQSCSEDPALPWEQ	TROAP	376	Q12815
SENPPDLNKIWSEPF	PRKDC	3021	P78527
TPDQELAPASEPVWE	WASHC2A	6	Q641Q2
FNPWSPEDDVYLPSE	TGM7	141	Q96PF1
TKEQFGWPDEPPEEF	UBR4	2426	Q5T4S7
DLSEPPNWSANFDVP	PPP6R3	676	Q5H9R7
LDWPFDDGAPPSNQI	PTP4A1	66	Q93096
PPIWSVESDDPNLAA	UBE2Q1	116	Q7Z7E8
WKNDQEPPPEALDFS	NAF1	301	Q96HR8