Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3T6 kinase activity	PRKCA PRKCB	3.72e-06	2	39	2	GO:0035403
GeneOntologyMolecularFunction	natriuretic peptide receptor activity	NPR1 NPR2	1.11e-05	3	39	2	GO:0016941
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR1 NPR2	1.66e-04	10	39	2	GO:0004383
GeneOntologyMolecularFunction	histone H3 kinase activity	PRKCA PRKCB	2.42e-04	12	39	2	GO:0140996
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCB	4.38e-04	16	39	2	GO:0004697
GeneOntologyMolecularFunction	adenylate cyclase activity	NPR1 NPR2	5.58e-04	18	39	2	GO:0004016
GeneOntologyMolecularFunction	kinase activity	PRKCA PRKCB SEPHS2 NPR1 NPR2 MAST4 ALPK2	6.16e-04	764	39	7	GO:0016301
GeneOntologyMolecularFunction	lyase activity	NPR1 ETNPPL NPR2 HCCS	7.59e-04	212	39	4	GO:0016829
GeneOntologyMolecularFunction	cyclase activity	NPR1 NPR2	9.98e-04	24	39	2	GO:0009975
GeneOntologyMolecularFunction	protein kinase activity	PRKCA PRKCB NPR1 NPR2 MAST4 ALPK2	1.01e-03	600	39	6	GO:0004672
GeneOntologyMolecularFunction	hormone binding	NPR1 NPR2 CALR	1.06e-03	103	39	3	GO:0042562
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR1 NPR2	1.08e-03	25	39	2	GO:0016849
GeneOntologyMolecularFunction	histone kinase activity	PRKCA PRKCB	1.36e-03	28	39	2	GO:0035173
GeneOntologyMolecularFunction	nuclear androgen receptor binding	PRKCB CALR	1.89e-03	33	39	2	GO:0050681
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PRKCA PRKCB SEPHS2 NPR1 NPR2 MAST4 ALPK2	2.03e-03	938	39	7	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PRKCA PRKCB NPR1 NPR2 MAST4 ALPK2	2.35e-03	709	39	6	GO:0016773
GeneOntologyMolecularFunction	peptide receptor activity	SORCS3 NPR1 NPR2	2.56e-03	140	39	3	GO:0001653
GeneOntologyMolecularFunction	integrin binding	PRKCA CALR ITGB1BP2	4.80e-03	175	39	3	GO:0005178
GeneOntologyMolecularFunction	peptide hormone binding	NPR1 NPR2	5.17e-03	55	39	2	GO:0017046
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1S CLCN2 KCNJ4	5.35e-03	182	39	3	GO:0005244
GeneOntologyMolecularFunction	protein serine kinase activity	PRKCA PRKCB MAST4 ALPK2	5.35e-03	363	39	4	GO:0106310
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1S CLCN2 KCNJ4	5.51e-03	184	39	3	GO:0022832
GeneOntologyMolecularFunction	cell adhesion molecule binding	PRKCA ADGRL1 TJP1 CALR ITGB1BP2	5.92e-03	599	39	5	GO:0050839
GeneOntologyMolecularFunction	protein domain specific binding	FOXA3 HAP1 TJP1 INPP5A KCNJ4 ITGB1BP2	6.59e-03	875	39	6	GO:0019904
GeneOntologyMolecularFunction	zinc ion binding	PRKCA PRKCB FBXL19 ASTL CALR ITGB1BP2	7.18e-03	891	39	6	GO:0008270
GeneOntologyCellularComponent	cortical granule	ASTL CALR	5.06e-05	6	39	2	GO:0060473
GeneOntologyCellularComponent	presynaptic cytosol	PRKCA PRKCB HAP1	1.04e-04	49	39	3	GO:0099523
GeneOntologyCellularComponent	cytosolic region	PRKCA PRKCB HAP1	3.01e-04	70	39	3	GO:0099522
GeneOntologyCellularComponent	dendrite	LAMA2 PRKCA CACNA1S CLCN2 HAP1 INPP5A KCNJ4	9.33e-04	858	39	7	GO:0030425
GeneOntologyCellularComponent	dendritic tree	LAMA2 PRKCA CACNA1S CLCN2 HAP1 INPP5A KCNJ4	9.46e-04	860	39	7	GO:0097447
Domain	ANF_RECEPTORS	NPR1 NPR2	1.27e-05	3	39	2	PS00458
Domain	ANPR/GUC	NPR1 NPR2	1.27e-05	3	39	2	IPR001170
Domain	Protein_kinase_C_a/b/g	PRKCA PRKCB	1.27e-05	3	39	2	IPR014375
Domain	AGC-kinase_C	PRKCA PRKCB MAST4	2.16e-04	56	39	3	IPR000961
Domain	AGC_KINASE_CTER	PRKCA PRKCB MAST4	2.16e-04	56	39	3	PS51285
Domain	S_TK_X	PRKCA PRKCB MAST4	2.16e-04	56	39	3	SM00133
Domain	A/G_cyclase_CS	NPR1 NPR2	5.66e-04	17	39	2	IPR018297
Domain	Nucleotide_cyclase	NPR1 NPR2	6.36e-04	18	39	2	IPR029787
Domain	-	NPR1 NPR2	6.36e-04	18	39	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR1 NPR2	7.10e-04	19	39	2	PS00452
Domain	Guanylate_cyc	NPR1 NPR2	7.10e-04	19	39	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR1 NPR2	7.10e-04	19	39	2	PS50125
Domain	A/G_cyclase	NPR1 NPR2	7.10e-04	19	39	2	IPR001054
Domain	CYCc	NPR1 NPR2	7.10e-04	19	39	2	SM00044
Domain	Kinase-like_dom	PRKCA PRKCB NPR1 NPR2 MAST4 ALPK2	8.39e-04	542	39	6	IPR011009
Domain	DAG/PE-bd	PRKCA PRKCB	8.70e-04	21	39	2	IPR020454
Domain	-	LAMA2 LGALSL CALR	1.02e-03	95	39	3	2.60.120.200
Domain	ANF_lig-bd_rcpt	NPR1 NPR2	2.70e-03	37	39	2	IPR001828
Domain	Pkinase_C	PRKCA PRKCB	2.70e-03	37	39	2	IPR017892
Domain	ANF_receptor	NPR1 NPR2	2.70e-03	37	39	2	PF01094
Domain	Peripla_BP_I	NPR1 NPR2	3.00e-03	39	39	2	IPR028082
Domain	Prot_kinase_dom	PRKCA PRKCB NPR1 NPR2 MAST4	3.33e-03	489	39	5	IPR000719
Domain	PROTEIN_KINASE_DOM	PRKCA PRKCB NPR1 NPR2 MAST4	3.45e-03	493	39	5	PS50011
Domain	Pkinase_C	PRKCA PRKCB	3.47e-03	42	39	2	PF00433
Domain	TF_fork_head_CS_2	FOXN1 FOXA3	4.15e-03	46	39	2	IPR030456
Domain	TF_fork_head_CS_1	FOXN1 FOXA3	4.33e-03	47	39	2	IPR018122
Domain	FH	FOXN1 FOXA3	4.70e-03	49	39	2	SM00339
Domain	FORK_HEAD_1	FOXN1 FOXA3	4.70e-03	49	39	2	PS00657
Domain	FORK_HEAD_2	FOXN1 FOXA3	4.70e-03	49	39	2	PS00658
Domain	Fork_head_dom	FOXN1 FOXA3	4.70e-03	49	39	2	IPR001766
Domain	FORK_HEAD_3	FOXN1 FOXA3	4.70e-03	49	39	2	PS50039
Domain	Forkhead	FOXN1 FOXA3	4.70e-03	49	39	2	PF00250
Domain	C2_dom	PRKCA PRKCB TNS1	4.82e-03	164	39	3	IPR000008
Domain	C1_1	PRKCA PRKCB	6.31e-03	57	39	2	PF00130
Domain	ZF_DAG_PE_1	PRKCA PRKCB	7.89e-03	64	39	2	PS00479
Domain	ZF_DAG_PE_2	PRKCA PRKCB	7.89e-03	64	39	2	PS50081
Domain	Pkinase	PRKCA PRKCB NPR2 MAST4	7.98e-03	381	39	4	PF00069
Domain	C1	PRKCA PRKCB	8.13e-03	65	39	2	SM00109
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	PRKCA CACNA1S PRKCB NPR1 NPR2	4.01e-06	115	30	5	M9387
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	4.36e-05	5	30	2	MM1574
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	4.36e-05	5	30	2	MM1587
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	4.36e-05	5	30	2	M22059
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	4.36e-05	5	30	2	M22080
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	PRKCA PRKCB	4.36e-05	5	30	2	M26920
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	9.13e-05	7	30	2	MM1563
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	9.13e-05	7	30	2	MM1572
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	9.13e-05	7	30	2	M22043
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	9.13e-05	7	30	2	M22057
Pathway	REACTOME_PHYSIOLOGICAL_FACTORS	NPR1 NPR2	9.13e-05	7	30	2	MM15201
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.22e-04	8	30	2	M47479
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US27_TO_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.22e-04	8	30	2	M47555
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	1.56e-04	9	30	2	M22029
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	1.56e-04	9	30	2	MM1551
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	1.95e-04	10	30	2	MM1341
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	1.95e-04	10	30	2	MM1352
Pathway	KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.95e-04	10	30	2	M47644
Pathway	KEGG_VIBRIO_CHOLERAE_INFECTION	PRKCA PRKCB TJP1	2.00e-04	54	30	3	M17906
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	2.38e-04	11	30	2	MM1360
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	2.38e-04	11	30	2	M19829
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	2.38e-04	11	30	2	M47637
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	2.38e-04	11	30	2	M10994
Pathway	BIOCARTA_MYOSIN_PATHWAY	PRKCA PRKCB	2.38e-04	11	30	2	M7014
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	PRKCA CACNA1S PRKCB CALR	2.52e-04	147	30	4	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	PRKCA CACNA1S PRKCB CALR	2.79e-04	151	30	4	M39329
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	2.85e-04	12	30	2	M16973
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	2.85e-04	12	30	2	M47597
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	2.85e-04	12	30	2	M47649
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	PRKCA PRKCB	2.85e-04	12	30	2	M47628
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PRKCA PRKCB	3.37e-04	13	30	2	M47656
Pathway	PID_TCR_RAS_PATHWAY	PRKCA PRKCB	3.92e-04	14	30	2	M134
Pathway	REACTOME_PHYSIOLOGICAL_FACTORS	NPR1 NPR2	3.92e-04	14	30	2	M27459
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	3.92e-04	14	30	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	3.92e-04	14	30	2	M47384
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB	3.92e-04	14	30	2	M9134
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	4.52e-04	15	30	2	MM1358
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB	4.52e-04	15	30	2	MM1523
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	PRKCA PRKCB	4.52e-04	15	30	2	M27413
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	4.52e-04	15	30	2	M47382
Pathway	REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA	PRKCA PRKCB	4.52e-04	15	30	2	M27360
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	5.16e-04	16	30	2	MM1483
Pathway	BIOCARTA_SPPA_PATHWAY	PRKCA PRKCB	5.16e-04	16	30	2	M8731
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	5.16e-04	16	30	2	M4388
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PRKCA PRKCB INPP5A	5.51e-04	76	30	3	M9052
Pathway	BIOCARTA_CCR5_PATHWAY	PRKCA PRKCB	5.84e-04	17	30	2	M2349
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	PRKCA PRKCB	5.84e-04	17	30	2	M5488
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	M3430
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	MM1350
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	MM1479
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	M7552
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	M5290
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	M3873
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	6.56e-04	18	30	2	MM1385
Pathway	BIOCARTA_CCR5_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	MM1453
Pathway	BIOCARTA_CCR3_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	MM1361
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	PRKCA PRKCB	7.32e-04	19	30	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PRKCA PRKCB	7.32e-04	19	30	2	M47596
Pathway	BIOCARTA_PAR1_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	MM1514
Pathway	BIOCARTA_PAR1_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	M3494
Pathway	BIOCARTA_CXCR4_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	MM1375
Pathway	BIOCARTA_CXCR4_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	M882
Pathway	BIOCARTA_CCR3_PATHWAY	PRKCA PRKCB	7.32e-04	19	30	2	M9152
Pathway	BIOCARTA_NOS1_PATHWAY	PRKCA PRKCB	8.12e-04	20	30	2	MM1445
Pathway	BIOCARTA_EDG1_PATHWAY	PRKCA PRKCB	8.12e-04	20	30	2	MM1456
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB	8.12e-04	20	30	2	MM1520
Pathway	BIOCARTA_ARENRF2_PATHWAY	PRKCA PRKCB	8.12e-04	20	30	2	M14339
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	8.97e-04	21	30	2	M47638
Pathway	BIOCARTA_NOS1_PATHWAY	PRKCA PRKCB	8.97e-04	21	30	2	M11650
Pathway	KEGG_GAP_JUNCTION	PRKCA PRKCB TJP1	9.02e-04	90	30	3	M4013
Pathway	REACTOME_PCP_CE_PATHWAY	PSMC4 PRKCA PRKCB	9.61e-04	92	30	3	M27322
Pathway	BIOCARTA_ARENRF2_PATHWAY	PRKCA PRKCB	9.85e-04	22	30	2	MM1449
Pathway	BIOCARTA_EDG1_PATHWAY	PRKCA PRKCB	9.85e-04	22	30	2	M10579
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB	9.85e-04	22	30	2	M9070
Pathway	BIOCARTA_EIF4_PATHWAY	PRKCA PRKCB	1.08e-03	23	30	2	MM1470
Pathway	BIOCARTA_EIF4_PATHWAY	PRKCA PRKCB	1.17e-03	24	30	2	M4791
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	PRKCA PRKCB	1.17e-03	24	30	2	M27553
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB	1.17e-03	24	30	2	M11520
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	PRKCA CACNA1S PRKCB	1.26e-03	101	30	3	M1979
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB	1.27e-03	25	30	2	MM1519
Pathway	REACTOME_CARDIAC_CONDUCTION	NPR1 NPR2 KCNJ4	1.33e-03	103	30	3	MM15196
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB	1.38e-03	26	30	2	MM1346
Pathway	PID_VEGFR1_PATHWAY	PRKCA PRKCB	1.38e-03	26	30	2	M226
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB	1.38e-03	26	30	2	MM1431
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.38e-03	26	30	2	M47557
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB	1.49e-03	27	30	2	M14899
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB	1.49e-03	27	30	2	M7739
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB	1.49e-03	27	30	2	M1909
Pathway	BIOCARTA_VEGF_PATHWAY	PRKCA PRKCB	1.49e-03	27	30	2	M12975
Pathway	BIOCARTA_GH_PATHWAY	PRKCA PRKCB	1.49e-03	27	30	2	M9043
Pathway	WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE	PRKCA PRKCB	1.60e-03	28	30	2	M42536
Pathway	PID_IL8_CXCR1_PATHWAY	PRKCA PRKCB	1.60e-03	28	30	2	M252
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB	1.60e-03	28	30	2	MM1386
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB	1.60e-03	28	30	2	M2529
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB	1.72e-03	29	30	2	MM1452
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	PRKCA PRKCB	1.72e-03	29	30	2	MM1356
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	PRKCA PRKCB	1.72e-03	29	30	2	M13494
Pathway	WP_PDGFRBETA_PATHWAY	PRKCA PRKCB	1.72e-03	29	30	2	M39616
Pathway	BIOCARTA_GPCR_PATHWAY	PRKCA PRKCB	1.72e-03	29	30	2	MM1495
Pathway	PID_RAS_PATHWAY	PRKCA PRKCB	1.84e-03	30	30	2	M269
Pubmed	ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling.	NPR1 NPR2 TJP1	1.30e-08	5	39	3	23324181
Pubmed	Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.	PRKCA PRKCB	1.23e-06	2	39	2	26660275
Pubmed	Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.	PRKCA PRKCB	1.23e-06	2	39	2	16673150
Pubmed	Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.	PRKCA PRKCB	1.23e-06	2	39	2	16517978
Pubmed	Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.	PRKCA PRKCB	1.23e-06	2	39	2	25693686
Pubmed	The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.	NPR1 NPR2	1.23e-06	2	39	2	30696704
Pubmed	Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.	PRKCA PRKCB	1.23e-06	2	39	2	21658591
Pubmed	Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP.	NPR1 NPR2	1.23e-06	2	39	2	17848634
Pubmed	Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.	PRKCA PRKCB	1.23e-06	2	39	2	24151077
Pubmed	Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB.	NPR1 NPR2	1.23e-06	2	39	2	23186809
Pubmed	Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.	PRKCA PRKCB	1.23e-06	2	39	2	29307535
Pubmed	Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.	PRKCA PRKCB	1.23e-06	2	39	2	16080189
Pubmed	Receptor-specific regulation of atrial GIRK channel activity by different Ca2+-dependent PKC isoforms.	PRKCA PRKCB	1.23e-06	2	39	2	31525436
Pubmed	Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.	NPR1 NPR2	1.23e-06	2	39	2	20977274
Pubmed	Unravelling the different functions of protein kinase C isoforms in platelets.	PRKCA PRKCB	1.23e-06	2	39	2	21596041
Pubmed	Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.	PRKCA PRKCB	1.23e-06	2	39	2	25616575
Pubmed	PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.	PRKCA PRKCB	1.23e-06	2	39	2	23439007
Pubmed	ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding.	NPR1 NPR2	1.23e-06	2	39	2	21828054
Pubmed	All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.	PRKCA PRKCB	1.23e-06	2	39	2	33723318
Pubmed	Porcine natriuretic peptide type B (pNPPB) maintains mouse oocyte meiotic arrest via natriuretic peptide receptor 2 (NPR2) in cumulus cells.	NPR1 NPR2	1.23e-06	2	39	2	24615855
Pubmed	Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC.	PRKCA PRKCB	1.23e-06	2	39	2	22993418
Pubmed	Vasonatrin peptide stimulates both of the natriuretic peptide receptors, NPRA and NPRB.	NPR1 NPR2	1.23e-06	2	39	2	24699414
Pubmed	Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte.	NPR1 NPR2	1.23e-06	2	39	2	22133375
Pubmed	The essentiality of PKCalpha and PKCbetaI translocation for CD14+monocyte differentiation towards macrophages and dendritic cells, respectively.	PRKCA PRKCB	1.23e-06	2	39	2	17455194
Pubmed	Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.	PRKCA PRKCB	1.23e-06	2	39	2	27657532
Pubmed	Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-α and βI isozymes.	PRKCA PRKCB	1.23e-06	2	39	2	21323641
Pubmed	Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held.	PRKCA PRKCB	1.23e-06	2	39	2	23035091
Pubmed	Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells.	PRKCA PRKCB	1.23e-06	2	39	2	9486851
Pubmed	Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain.	NPR1 NPR2	1.23e-06	2	39	2	22949736
Pubmed	Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.	PRKCA PRKCB	1.23e-06	2	39	2	16430878
Pubmed	Enhanced expression of natriuretic peptide receptor A and B in neutrophils of culprit lesions in patients with acute myocardial infarction.	NPR1 NPR2	1.23e-06	2	39	2	28765884
Pubmed	Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.	PRKCA PRKCB	1.23e-06	2	39	2	28415683
Pubmed	Inhibition of the calcium release-activated calcium (CRAC) current in Jurkat T cells by the HIV-1 envelope protein gp160.	PRKCA PRKCB	1.23e-06	2	39	2	11744714
Pubmed	ATP-independent activation of natriuretic peptide receptors.	NPR1 NPR2	1.23e-06	2	39	2	15911610
Pubmed	The indolocarbazole, Gö6976, inhibits guanylyl cyclase-A and -B.	NPR1 NPR2	1.23e-06	2	39	2	21366551
Pubmed	cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.	PRKCA PRKCB	1.23e-06	2	39	2	14527960
Pubmed	Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.	PRKCA PRKCB	3.67e-06	3	39	2	23434935
Pubmed	Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.	PRKCA PRKCB	3.67e-06	3	39	2	1324914
Pubmed	A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.	PRKCA PRKCB	3.67e-06	3	39	2	24316392
Pubmed	Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.	PRKCA PRKCB	3.67e-06	3	39	2	9814702
Pubmed	Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans.	PRKCA PRKCB	3.67e-06	3	39	2	16775601
Pubmed	Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.	PRKCA PRKCB	3.67e-06	3	39	2	17936705
Pubmed	A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A.	NPR1 NPR2	3.67e-06	3	39	2	16430226
Pubmed	Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.	PRKCA PRKCB	3.67e-06	3	39	2	23028752
Pubmed	Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.	PRKCA PRKCB	3.67e-06	3	39	2	7760054
Pubmed	Skeletal muscle derived Musclin protects the heart during pathological overload.	NPR1 NPR2	3.67e-06	3	39	2	35013221
Pubmed	Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling.	PRKCA PRKCB	3.67e-06	3	39	2	20237998
Pubmed	S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.	PRKCA PRKCB	3.67e-06	3	39	2	18162471
Pubmed	Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.	NPR1 NPR2	3.67e-06	3	39	2	29409758
Pubmed	The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.	PRKCA PRKCB	3.67e-06	3	39	2	12080070
Pubmed	Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates.	PRKCA PRKCB	3.67e-06	3	39	2	18313852
Pubmed	Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.	PRKCA PRKCB	3.67e-06	3	39	2	22819675
Pubmed	Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.	PRKCA PRKCB	3.67e-06	3	39	2	3755548
Pubmed	Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.	PRKCA PRKCB	3.67e-06	3	39	2	1714454
Pubmed	Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.	PRKCA PRKCB	3.67e-06	3	39	2	32367578
Pubmed	Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family.	NPR1 NPR2	3.67e-06	3	39	2	1979052
Pubmed	Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.	PRKCA PRKCB	3.67e-06	3	39	2	19895572
Pubmed	Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms.	PRKCA PRKCB	3.67e-06	3	39	2	22670899
Pubmed	Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.	PRKCA PRKCB	3.67e-06	3	39	2	19556521
Pubmed	Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implications.	NPR1 NPR2	3.67e-06	3	39	2	25117468
Pubmed	Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.	PRKCA PRKCB	3.67e-06	3	39	2	16735462
Pubmed	Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.	PRKCA PRKCB	3.67e-06	3	39	2	30904392
Pubmed	PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport.	PRKCA PRKCB	3.67e-06	3	39	2	23977398
Pubmed	Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue.	NPR1 NPR2	3.67e-06	3	39	2	36618828
Pubmed	Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.	PRKCA PRKCB	3.67e-06	3	39	2	19066285
Pubmed	Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.	NPR1 NPR2	3.67e-06	3	39	2	15459247
Pubmed	Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse.	PRKCA PRKCB	3.67e-06	3	39	2	27307229
Pubmed	Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.	PRKCA PRKCB	7.34e-06	4	39	2	9244383
Pubmed	Phosphorylation of p300 at serine 89 by protein kinase C.	PRKCA PRKCB	7.34e-06	4	39	2	11020388
Pubmed	STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.	PRKCA PRKCB	7.34e-06	4	39	2	24493668
Pubmed	Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.	PRKCA PRKCB	7.34e-06	4	39	2	26404773
Pubmed	Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.	PRKCA PRKCB	7.34e-06	4	39	2	10856305
Pubmed	Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.	PRKCA PRKCB	7.34e-06	4	39	2	15367584
Pubmed	Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.	PRKCA PRKCB	7.34e-06	4	39	2	15499829
Pubmed	Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.	PRKCA PRKCB	7.34e-06	4	39	2	22318721
Pubmed	Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.	PRKCA PRKCB	7.34e-06	4	39	2	9694886
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKCA PRKCB	7.34e-06	4	39	2	7873880
Pubmed	Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.	PRKCA PRKCB	7.34e-06	4	39	2	8080473
Pubmed	Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells.	PRKCA PRKCB	7.34e-06	4	39	2	11930178
Pubmed	Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase.	PRKCA PRKCB	7.34e-06	4	39	2	19681907
Pubmed	Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.	PRKCA PRKCB	7.34e-06	4	39	2	10871288
Pubmed	PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.	PRKCA PRKCB	7.34e-06	4	39	2	8557118
Pubmed	Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.	PRKCA PRKCB	7.34e-06	4	39	2	12950453
Pubmed	Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.	PRKCA PRKCB	7.34e-06	4	39	2	8631738
Pubmed	Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.	PRKCA PRKCB	7.34e-06	4	39	2	20618341
Pubmed	Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.	PRKCA PRKCB	7.34e-06	4	39	2	7499337
Pubmed	Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1.	PRKCA PRKCB	7.34e-06	4	39	2	34290081
Pubmed	Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.	PRKCA PRKCB	7.34e-06	4	39	2	8662663
Pubmed	Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition.	PRKCA PRKCB	7.34e-06	4	39	2	24401212
Pubmed	Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.	PRKCA PRKCB	7.34e-06	4	39	2	11063746
Pubmed	A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.	NPR1 NPR2	7.34e-06	4	39	2	19458086
Pubmed	Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.	PRKCA PRKCB	7.34e-06	4	39	2	10531036
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCA PRKCB	1.22e-05	5	39	2	7513693
Pubmed	Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth.	PRKCA PRKCB	1.22e-05	5	39	2	33917019
Pubmed	Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.	PRKCA PRKCB	1.22e-05	5	39	2	11123317
Pubmed	PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity.	PRKCA PRKCB	1.22e-05	5	39	2	30013171
Pubmed	Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.	PRKCA PRKCB	1.22e-05	5	39	2	1321150
Pubmed	Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.	PRKCA PRKCB	1.22e-05	5	39	2	28228266
Pubmed	Protein kinase C regulates the phosphorylation and cellular localization of occludin.	PRKCA PRKCB	1.22e-05	5	39	2	11502742
Pubmed	IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.	PRKCA PRKCB	1.22e-05	5	39	2	15488737
Cytoband	16p11.2	PRKCB SEPHS2 FBXL19	5.80e-04	191	39	3	16p11.2
GeneFamily	Guanylate cyclase receptors	NPR1 NPR2	4.16e-05	7	26	2	343
GeneFamily	C2 domain containing protein kinases	PRKCA PRKCB	8.89e-05	10	26	2	835
GeneFamily	Forkhead boxes	FOXN1 FOXA3	1.73e-03	43	26	2	508
GeneFamily	PDZ domain containing	MAST4 TJP1	2.00e-02	152	26	2	1220
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA PRKCB HAP1 ZNF804B	1.33e-05	166	39	4	66026988509e39e41274fa0de738383219e8ff30
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	NPR1 ZBTB7C TNS1 ALPK2	1.53e-05	172	39	4	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA ADGRL1 PRKCB HAP1	2.30e-05	191	39	4	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LAMA2 HAP1 TNS1 TJP1	2.60e-05	197	39	4	44cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA2 ZBTB7C TJP1 ALPK2	2.60e-05	197	39	4	dfeb4a0eb4dfba90f4a3e6ba31e0ab0e4aba5849
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	LAMA2 MAST4 TNS1 INPP5A	2.76e-05	200	39	4	7136936d05ab344a560cf159684c881063b5430d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal\|6m / Sample Type, Dataset, Time_group, and Cell type.	CACNA1S NWD1 DNAH12 ITGB1BP2	2.76e-05	200	39	4	13ec8afea86e4a10599c924871ba4e325b0a8013
ToppCell	LPS-IL1RA-Endothelial-Epi-like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPR1 ETNPPL SPINK5	1.43e-04	116	39	3	cf4e3c34570f57502ec524881d351ef8e47976d2
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPR1 ETNPPL SPINK5	2.38e-04	138	39	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	metastatic_Lymph_Node-T/NK_cells-CD8_low_T\|T/NK_cells / Location, Cell class and cell subclass	LAMA2 NWD1 TJP1	2.92e-04	148	39	3	db046a02a00829910bf9d7dbda068e730aa78f00
ToppCell	Influenza_Severe-CD4+_T_naive\|World / Disease group and Cell class	PRKCA SALL2 MAST4	2.98e-04	149	39	3	ce6552063510aa3e0b9d6e5b531eea67410e7056
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S PRKCB KCNJ4	2.98e-04	149	39	3	a6e192bf9bcf3b219e618c465bc451f7c86f49f1
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	HAP1 TNS1 ALPK2	2.98e-04	149	39	3	e9974260a5f2999b363f306cae005698c912893a
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 ETNPPL NWD1	3.22e-04	153	39	3	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 ETNPPL NWD1	3.22e-04	153	39	3	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 ETNPPL NWD1	3.22e-04	153	39	3	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NWD1 ZBTB7C INPP5A	3.35e-04	155	39	3	96c48d835725eac1bc7926f4cddecb67c29b7d7c
ToppCell	Influenza_Severe-CD4+_T_naive\|Influenza_Severe / Disease group and Cell class	PRKCA SALL2 MAST4	3.47e-04	157	39	3	287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCell	severe_influenza-CD4+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	PRKCA SALL2 MAST4	3.54e-04	158	39	3	ff3fa4bd06e01363429aec4bb587b95819bf0fc9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	3.60e-04	159	39	3	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA CACNA1S PRKCB	3.60e-04	159	39	3	656aa20706bdba81bbcc3e68e6058215b92b8802
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S PRKCB ALPK2	3.74e-04	161	39	3	98be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S PRKCB ALPK2	3.74e-04	161	39	3	7af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	HEATR5A ZBTB7C LRRC75A	3.81e-04	162	39	3	7d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAH12 ZBTB7C SPINK5	3.95e-04	164	39	3	d9531848105d606adedde65426177cf851140e31
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S PRKCB ALPK2	4.02e-04	165	39	3	8a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LAMA2 NPR1 SALL2	4.09e-04	166	39	3	f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA ADGRL1 NPR2	4.16e-04	167	39	3	d30b96c39da3dd02500443877a4eb3500e26802c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA ADGRL1 NPR2	4.16e-04	167	39	3	713899690e4acd9d259645e363c26983d6ef3022
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASTL LRRC75A SPINK5	4.16e-04	167	39	3	720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1S ZBTB7C TJP1	4.23e-04	168	39	3	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1S ZBTB7C TJP1	4.23e-04	168	39	3	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	4.38e-04	170	39	3	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	4.38e-04	170	39	3	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXN1 CLCN2 HCCS	4.38e-04	170	39	3	833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	LAMA2 HAP1 TNS1	4.46e-04	171	39	3	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRMT13 CLCN2 LRRC75A	4.61e-04	173	39	3	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 LGALSL TNS1	4.61e-04	173	39	3	cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 LGALSL TNS1	4.61e-04	173	39	3	f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB MAST4 ALPK2	4.69e-04	174	39	3	fbf998dd33ac27dad7639ea85fca393ba2835307
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB MAST4 ALPK2	4.69e-04	174	39	3	8bdf5a97faf1cf0426d1a8851f8a3e27578f7598
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 SORCS3 ZNF804B	4.77e-04	175	39	3	3f233a7e19f594e0343f02286299cc42c711994c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 SORCS3 ZNF804B	4.77e-04	175	39	3	23acfbcc1eb5a066195a9fde20aa51b7303a81af
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Follicular-7\|TCGA-Thryoid / Sample_Type by Project: Shred V9	SEPHS2 HAP1 HCCS	4.85e-04	176	39	3	9a4cef3dc88f64a71b91ab4790ea19334afee3ee
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRL1 ETNPPL NWD1	4.85e-04	176	39	3	ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCell	primary_visual_cortex-Non-neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 ETNPPL NWD1	4.85e-04	176	39	3	2c92f3f55d668cfe80051b5128160a6dc3aec4e8
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA NPR2 LGALSL	4.85e-04	176	39	3	8e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DNAH12 LGALSL TNS1	4.93e-04	177	39	3	e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DNAH12 LGALSL TNS1	4.93e-04	177	39	3	0830944c43de300815831a9e2b2fce40965e7d12
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	NPR1 ZBTB7C ALPK2	5.09e-04	179	39	3	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.09e-04	179	39	3	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Erythrophagocytic_macrophages\|bone_marrow / Manually curated celltypes from each tissue	SEPHS2 HEATR5A TNS1	5.18e-04	180	39	3	daf69a548ed7c6f285a6adcff00f99aa22f9d6a5
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRMT13 CLCN2 LRRC75A	5.18e-04	180	39	3	a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 MAST4 ZBTB7C	5.18e-04	180	39	3	5391d23817f5cc88a0871ddb98968897c839f464
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXN1 ZBTB7C FOXA3	5.18e-04	180	39	3	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.26e-04	181	39	3	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.26e-04	181	39	3	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1S NPR1 TJP1	5.35e-04	182	39	3	cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NPR1 TNS1 TJP1	5.35e-04	182	39	3	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NPR1 TNS1 TJP1	5.35e-04	182	39	3	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ALPK2 ITGB1BP2	5.35e-04	182	39	3	edfc598b7199ca1d8a399b264ab863c299b1eede
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 PRKCA GSPT2	5.35e-04	182	39	3	f4b74c2756989812abe4e7055ec8918f69d56025
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C TJP1	5.43e-04	183	39	3	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	MAST4 ALPK2 ZNF804B	5.52e-04	184	39	3	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 MAST4 ZBTB7C	5.52e-04	184	39	3	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NPR1 TNS1 TJP1	5.52e-04	184	39	3	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	MAST4 ALPK2 ZNF804B	5.52e-04	184	39	3	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.52e-04	184	39	3	9434731f651820b05335085582960f08fbf895de
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C TJP1	5.61e-04	185	39	3	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C ALPK2	5.61e-04	185	39	3	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 ZBTB7C HAP1	5.61e-04	185	39	3	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C ALPK2	5.61e-04	185	39	3	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1S ETNPPL NWD1	5.69e-04	186	39	3	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 PRKCA GSPT2	5.69e-04	186	39	3	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPR1 SALL2 INPP5A	5.69e-04	186	39	3	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 PRKCA GSPT2	5.69e-04	186	39	3	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPR1 SALL2 INPP5A	5.69e-04	186	39	3	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA CACNA1S PRKCB	5.69e-04	186	39	3	0018a949f9f5bfc17f823601303f04dfd56c9a38
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.69e-04	186	39	3	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	5.78e-04	187	39	3	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.78e-04	187	39	3	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	5.78e-04	187	39	3	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	MAST4 ALPK2 ZNF804B	5.78e-04	187	39	3	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.78e-04	187	39	3	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRKCA MAST4 LRRC75A	5.87e-04	188	39	3	2b630b0609d4ac61338d6533cb7893cfe1241e44
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LAMA2 PRKCA TNS1	5.87e-04	188	39	3	f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPR1 TJP1 INPP5A	5.87e-04	188	39	3	73f6ec915934154f435a376cb274b058ff7c5f35
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C ALPK2	5.87e-04	188	39	3	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 ZBTB7C ALPK2	5.87e-04	188	39	3	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCA ADGRL1 PRKCB	5.87e-04	188	39	3	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMA2 TNS1 TJP1	5.87e-04	188	39	3	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	facs-Tongue-nan-24m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXN1 LGALSL SPINK5	5.87e-04	188	39	3	ed35e438796cef302b6787c111753425922792dc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.87e-04	188	39	3	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 PRKCA LRRC75A	5.87e-04	188	39	3	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ALPK2 ZNF804B	5.87e-04	188	39	3	0792432cd4c564dea1102241ea9884f7ced7658c
Computational	Genes in the cancer module 65.	NPR1 NPR2	2.13e-04	10	24	2	MODULE_65
Computational	Genes in the cancer module 445.	NPR1 NPR2	4.93e-04	15	24	2	MODULE_445
Computational	Neighborhood of ATOX1	PSMC4 HARS2 SEPHS2	7.18e-04	80	24	3	MORF_ATOX1
Drug	pinacidil	PRKCA PRKCB NPR1 NPR2 KCNJ4	3.77e-07	87	39	5	CID000004826
Drug	tetraethylammonium	PRKCA CACNA1S PRKCB NPR1 NPR2 KCNJ4	2.85e-06	236	39	6	CID000005413
Drug	Erythrityl Tetranitrate	NPR1 NPR2	2.86e-06	2	39	2	DB01613
Drug	12-hydroxydaphnetoxin	PRKCA PRKCB	2.86e-06	2	39	2	CID000099841
Drug	Barium permanganate	PRKCA CACNA1S PRKCB NPR2 KCNJ4	3.10e-06	133	39	5	CID000024587
Drug	Ct-15	PRKCA PRKCB CALR	3.11e-06	17	39	3	CID003034917
Drug	glibenclamide	PRKCA PRKCB NPR1 NPR2 CLCN2 FOXA3 KCNJ4	3.43e-06	382	39	7	CID000003488
Drug	4-AP	PSMC4 PRKCA PRKCB NPR1 NPR2 KCNJ4	4.76e-06	258	39	6	CID000001727
Drug	barium	PRKCA CACNA1S PRKCB NPR1 KCNJ4	5.23e-06	148	39	5	CID000104810
Drug	8-Br	PRKCA PRKCB NPR1 NPR2 CLCN2	6.76e-06	156	39	5	CID000168120
Drug	octahydromezerein	PRKCA PRKCB	8.57e-06	3	39	2	CID000164152
Drug	Nesiritide	NPR1 NPR2	8.57e-06	3	39	2	DB04899
Drug	pentaerythritol tetranitrate	ADGRL1 NPR1 KCNJ4	1.32e-05	27	39	3	CID000006518
Drug	AC1L1B58	LAMA2 PRKCA PRKCB	1.65e-05	29	39	3	CID000001288
Drug	H-9 dihydrochloride	LAMA2 PRKCA PRKCB NPR1	1.69e-05	90	39	4	CID000003544
Drug	KT5720	PRKCA PRKCB NPR1 NPR2 KCNJ4	1.71e-05	189	39	5	CID000003844
Drug	daphnetoxin	PRKCA PRKCB	1.71e-05	4	39	2	CID000119454
Drug	Calcium	PRKCA ADGRL1 PRKCB NPR1 TJP1 CALR ITGB1BP2	1.80e-05	493	39	7	ctd:D002118
Drug	AC1L3G0K	PRKCA CACNA1S PRKCB	1.83e-05	30	39	3	CID000114822
Drug	12-deoxyphorbol 13-phenylacetate	PRKCA PRKCB TJP1	1.83e-05	30	39	3	CID000105100
Drug	atrial peptide	PRKCA NPR1 NPR2	2.02e-05	31	39	3	CID005490906
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	PRKCA ADGRL1 TRMT13 CLCN2 HCCS	2.04e-05	196	39	5	1001_DN
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	PRKCA ADGRL1 NPR2 HAP1 TNS1	2.04e-05	196	39	5	3783_DN
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	PRKCA ADGRL1 NPR2 SALL2 MAST4	2.04e-05	196	39	5	7187_DN
Drug	Indoprofen [31842-01-0]; Up 200; 14.2uM; PC3; HT_HG-U133A	LAMA2 PRKCA CACNA1S NPR2 SUCLG1	2.09e-05	197	39	5	4249_UP
Drug	Naftopidil dihydrochloride [57149-08-3]; Up 200; 8.6uM; PC3; HT_HG-U133A	LAMA2 PRKCA NPR1 HAP1 TNS1	2.19e-05	199	39	5	4193_UP
Drug	valinomycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	LAMA2 MAST4 HAP1 KCNJ4 SPINK5	2.19e-05	199	39	5	5906_DN
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	PRKCA ADGRL1 PRKCB NPR2 HAP1	2.19e-05	199	39	5	2747_UP
Drug	hexamethylmelamine	ADGRL1 NPR2 CLCN2 TNS1	2.77e-05	102	39	4	CID000002123
Drug	5-methylisatin	NPR1 NPR2	2.85e-05	5	39	2	CID000011840
Drug	12-deoxyphorbolphenylacetate-20-acetate	PRKCA PRKCB	2.85e-05	5	39	2	ctd:C029705
Drug	Ro 31-8830	PRKCA PRKCB CLCN2 KCNJ4	2.99e-05	104	39	4	CID000005084
Drug	IBMX	PRKCA PRKCB NPR1 NPR2 CLCN2 CALR	3.56e-05	368	39	6	CID000003758
Drug	potassium	PRKCA CACNA1S PRKCB NPR1 NPR2 CLCN2 CALR KCNJ4 ALPK2	4.02e-05	1008	39	9	CID000000813
Drug	ruboxistaurin	PRKCA PRKCB	4.27e-05	6	39	2	ctd:C099154
Drug	thymeleatoxin	PRKCA PRKCB	4.27e-05	6	39	2	ctd:C080287
Drug	NSC-351907	PRKCA PRKCB NPR1 NPR2 CLCN2	4.29e-05	229	39	5	CID000004016
Drug	D-myo-inositol-1,4,5-triphosphate	PRKCA CACNA1S PRKCB NPR1 HAP1 CALR INPP5A	4.46e-05	568	39	7	CID000000806
Drug	3-(1H-pyrrole-2-carboxylate	PRKCA CACNA1S PRKCB NPR2 CALR	4.66e-05	233	39	5	CID000005114
Drug	AC1NBU2S	CACNA1S NPR1 NPR2 HAP1	4.74e-05	117	39	4	CID004473765
Drug	ETYA	PRKCA PRKCB NPR1 CLCN2	5.58e-05	122	39	4	CID000001780
Drug	hexitol	PSMC4 PRKCA PRKCB TJP1 HCCS	5.69e-05	243	39	5	CID000000453
Drug	dibutyryl cyclic GMP	PRKCA PRKCB NPR1 NPR2	7.15e-05	130	39	4	CID000036095
Drug	2-bromoethylamine	NPR1 NPR2	7.95e-05	8	39	2	ctd:C004504
Drug	SQ22536	PRKCA PRKCB NPR1 NPR2	8.28e-05	135	39	4	CID000005270
Drug	propranolol	PRKCA CACNA1S PRKCB NPR1 CALR HCCS	8.87e-05	434	39	6	CID000004946
Drug	genistein	LAMA2 PRKCA CACNA1S PRKCB NPR2 CLCN2 TNS1 TJP1 KCNJ4	8.90e-05	1117	39	9	CID005280961
Drug	Ap 811	NPR1 NPR2	1.02e-04	9	39	2	CID000130279
Drug	U46619	PRKCA CACNA1S PRKCB NPR1 NPR2	1.21e-04	285	39	5	CID000005618
Drug	milrinone	ADGRL1 NPR1 NPR2 CALR	1.24e-04	150	39	4	CID000004197
Drug	Vitamin E	PRKCA PRKCB	1.28e-04	10	39	2	DB00163
Drug	sn-glycero-3-phosphoserine	PRKCA PRKCB	1.28e-04	10	39	2	CID000444182
Drug	Phosphatidylserines	PRKCA PRKCB	1.56e-04	11	39	2	ctd:D010718
Drug	FK143	ADGRL1 HCCS	1.56e-04	11	39	2	CID000178077
Drug	sodium	PRKCA CACNA1S PRKCB NPR1 CLCN2 TJP1 KCNJ4 ALPK2	1.66e-04	944	39	8	CID000000923
Drug	GDP-b-S	PRKCA PRKCB CLCN2 KCNJ4	1.67e-04	162	39	4	CID000643998
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	PRKCA CACNA1S PRKCB NPR1 NPR2	1.73e-04	308	39	5	CID000001915
Drug	D 609	PRKCA PRKCB CALR	1.80e-04	64	39	3	CID000002940
Drug	bryostatin 1	PRKCA PRKCB	1.87e-04	12	39	2	ctd:C046785
Drug	H Iv	NPR1 NPR2	1.87e-04	12	39	2	CID000301407
Drug	PETriN	PRKCB NPR1	1.87e-04	12	39	2	CID000015353
Drug	AC1L1ET5	PRKCA PRKCB KCNJ4	1.89e-04	65	39	3	CID000002936
Drug	1-(5-isoquinolinesulfonyl)-2-methylpiperazine	LAMA2 PSMC4 PRKCA PRKCB TNS1	1.89e-04	314	39	5	CID000003542
Drug	strontium	PRKCA PRKCB NPR1	2.16e-04	68	39	3	CID000104798
Drug	ONO-RS-082	PRKCA PRKCB CLCN2	2.35e-04	70	39	3	CID006438389
Drug	4 alpha-phorbol 12,13-didecanoate	PRKCA PRKCB NPR2	2.35e-04	70	39	3	CID000452543
Drug	AC1L1JVU	PRKCA CACNA1S PRKCB	2.55e-04	72	39	3	CID000005229
Drug	Go 6976	PRKCA PRKCB TJP1	2.88e-04	75	39	3	ctd:C081021
Drug	dansyl-DAG	PRKCA PRKCB	2.96e-04	15	39	2	CID000129493
Drug	RK-1409B	PRKCA PRKCB	2.96e-04	15	39	2	CID003036125
Drug	1-stearoyl-2-arachidonylglycerol	PRKCA PRKCB	2.96e-04	15	39	2	CID006443869
Drug	2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A_EA	NPR2 SALL2 MAST4 LGALSL	3.14e-04	191	39	4	994_UP
Drug	Simvastatin [79902-63-9]; Up 200; 9.6uM; PC3; HT_HG-U133A	LAMA2 NPR2 HAP1 SPINK5	3.20e-04	192	39	4	4244_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	ADGRL1 NPR2 MAST4 CLCN2	3.20e-04	192	39	4	5222_DN
Drug	miltefosine	PRKCA PRKCB TJP1	3.23e-04	78	39	3	CID000003599
Drug	AC1L1B9H	PRKCA PRKCB CLCN2	3.23e-04	78	39	3	CID000001341
Drug	Forskolin, from Coleus forskohlii; Down 200; 0.5uM; PC3; HT_HG-U133A	PRKCA ADGRL1 MAST4 TNS1	3.26e-04	193	39	4	7059_DN
Drug	Nimesulide [51803-78-2]; Up 200; 13uM; MCF7; HT_HG-U133A	PRKCA TNS1 KCNJ4 SPINK5	3.26e-04	193	39	4	2275_UP
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; HL60; HT_HG-U133A	PRKCA NPR2 SUCLG1 TJP1	3.33e-04	194	39	4	2180_UP
Drug	Alclometasone dipropionate [667634-13-2]; Up 200; 7.6uM; PC3; HT_HG-U133A	PRKCA MAST4 SUCLG1 KCNJ4	3.33e-04	194	39	4	5752_UP
Drug	Finasteride [98319-26-7]; Down 200; 10.8uM; HL60; HT_HG-U133A	ADGRL1 NPR2 SALL2 CLCN2	3.33e-04	194	39	4	2206_DN
Drug	Rp-cAMPS	PRKCA PRKCB NPR1 NPR2	3.33e-04	194	39	4	CID006426631
Drug	Dirithromycin [62013-04-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A	ADGRL1 NPR2 MAST4 CALR	3.33e-04	194	39	4	2863_DN
Drug	NU1025; Up 200; 100uM; MCF7; HG-U133A	LAMA2 PRKCA NPR2 TNS1	3.33e-04	194	39	4	608_UP
Drug	1uu9	PRKCA PRKCB	3.38e-04	16	39	2	CID000002398
Drug	AC1O517G	PRKCA PRKCB	3.38e-04	16	39	2	CID006450188
Drug	Anp (1-11)	NPR1 NPR2	3.38e-04	16	39	2	CID000127189
Drug	tert-Butyl Alcohol	PRKCA PRKCB	3.38e-04	16	39	2	ctd:D020002
Drug	Ethynodiol diacetate [297-76-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	NPR1 NPR2 MAST4 TNS1	3.39e-04	195	39	4	5024_UP
Drug	Berberine chloride [633-65-8]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ADGRL1 PRKCB SUCLG1 HAP1	3.39e-04	195	39	4	2770_UP
Drug	Diethylcarbamazine citrate [1642-54-2]; Up 200; 10.2uM; HL60; HT_HG-U133A	PRKCA NPR1 NPR2 SUCLG1	3.39e-04	195	39	4	2394_UP
Drug	2-propylpentanoic acid; Down 200; 1000uM; PC3; HT_HG-U133A	ADGRL1 MAST4 TNS1 SPINK5	3.39e-04	195	39	4	4433_DN
Drug	fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HG-U133A	SALL2 SUCLG1 HAP1 TNS1	3.46e-04	196	39	4	490_UP
Drug	Melatonin [73-31-4]; Down 200; 17.2uM; HL60; HT_HG-U133A	NPR2 CLCN2 SUCLG1 INPP5A	3.46e-04	196	39	4	2431_DN
Drug	haloperidol; Down 200; 10uM; PC3; HT_HG-U133A	LAMA2 PRKCA CLCN2 SPINK5	3.46e-04	196	39	4	4427_DN
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; HL60; HT_HG-U133A	CLCN2 SUCLG1 ITGB1BP2 SPINK5	3.53e-04	197	39	4	3098_UP
Drug	Amiprilose hydrochloride [60414-06-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A	PRKCA NPR1 NPR2 KCNJ4	3.53e-04	197	39	4	3339_UP
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	LAMA2 TNS1 KCNJ4 ITGB1BP2	3.53e-04	197	39	4	3744_UP
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; PC3; HT_HG-U133A	ADGRL1 NPR2 MAST4 TNS1	3.53e-04	197	39	4	6663_DN
Drug	Sulindac [38194-50-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	PRKCA ADGRL1 TRMT13 MAST4	3.53e-04	197	39	4	1693_DN
Disease	Cardiac Hypertrophy	PRKCA PRKCB NPR1	1.50e-04	82	37	3	C1383860
Disease	Cardiomegaly	PRKCA PRKCB NPR1	1.50e-04	82	37	3	C0018800
Disease	hypertension (implicated_via_orthology)	PRKCA PRKCB NPR1	5.56e-04	128	37	3	DOID:10763 (implicated_via_orthology)
Disease	Schizoaffective Disorder	PRKCA CALR	6.08e-04	29	37	2	C0036337
Disease	cortical surface area measurement	LAMA2 NPR2 MAST4 CLCN2 TNS1 TJP1 INPP5A	1.25e-03	1345	37	7	EFO_0010736
Disease	dilated cardiomyopathy (is_implicated_in)	PRKCA PRKCB	1.34e-03	43	37	2	DOID:12930 (is_implicated_in)
Disease	Heschl's gyrus morphology measurement	PRKCA ZNF804B	2.03e-03	53	37	2	EFO_0005852
Disease	isoleucine measurement	LAMA2 ZNF804B	2.26e-03	56	37	2	EFO_0009793

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLMPVFKPGHACVLK	ALPK2	1941	Q86TB3
EPKHPLGGREACGMD	ADGRL1	1226	O94910
HTGPVCAGVVGLKMP	NPR2	961	P20594
PPSGCPMHEGKMKGC	HCCS	21	P53701
HTGPVCAGVVGLKMP	NPR1	976	P16066
PGGCVPRNHFKGMSE	ASTL	416	Q6HA08
MGKPMGNGHPVACVV	ETNPPL	276	Q8TBG4
VHPGCLKMGKAEGVI	FBXL19	121	Q6PCT2
GPPGIGKTALMCKLA	NWD1	341	Q149M9
PKPCIMHVNGFLGAF	KCNJ4	111	P48050
LIVPFCGHIKGGMRP	LGALSL	36	Q3ZCW2
CGHIKGGMRPGKKVL	LGALSL	41	Q3ZCW2
IKGCTMGPHCAEKLP	ITGB1BP2	56	Q9UKP3
PVRGPDGKMHGNKCA	SPINK5	516	Q9NQ38
HCPKPEGDALGAMEK	LRRC75A	121	Q8NAA5
PKKDIHFMPCSGLTG	GSPT2	381	Q8IYD1
IGPNVCMGDHKPVFL	INPP5A	376	Q14642
VFGPPMGKKCIIFID	DNAH12	1946	Q6ZR08
KGPEMYCKLVEHVPG	LAMA2	61	P24043
MTKHPGKRLGCGPEG	PRKCB	576	P05771
CPLGIPHGKGKIIMT	HEATR5A	516	Q86XA9
LGPHSKPCVEMLKGL	CACNA1S	1711	Q13698
KMLQKGECPHGALPA	HAP1	646	P54257
MFGPDICGPGTKKVH	CALR	131	P27797
LKPKMTAGSHECLPG	MAST4	1706	O15021
EVMGPLEKPGGRHKC	SALL2	361	Q9Y467
EKLPVVGIGKHLCGM	TRMT13	256	Q9NUP7
GLVGMFDPKGHKVPC	HARS2	366	P49590
GPPGCGKTMLAKAVA	PSMC4	206	P43686
GLMTKHPAKRLGCGP	PRKCA	571	P17252
AKAQMCPGKAPRGLH	SORCS3	811	Q9UPU3
KVKPPVLESGAGMFC	FOXN1	201	O15353
GPGLVHGKEMPKGYR	FOXA3	96	P55318
INPGECKIGIMPGHI	SUCLG1	176	P53597
PLGKEGPFVHIASMC	CLCN2	201	P51788
GMKGUGCKVPQEALL	SEPHS2	56	Q99611
GSPHICDLGKVRPMK	ZNF804B	876	A4D1E1
MHGIPNFESKGGCRP	TNS1	191	Q9HBL0
PLVMCGPHGLKFLKP	TJP1	1696	Q07157
CPICHKVIMGAGKLP	ZBTB7C	366	A1YPR0