Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannokinase activity	HK1 GCK	1.39e-05	2	75	2	GO:0019158
GeneOntologyMolecularFunction	ATP-dependent activity	DHX15 HSP90B1 DDX46 DDX31 TMEM94 ABCB11 KIFC3 SNRNP200 XRCC6 KIFC1	9.63e-05	614	75	10	GO:0140657
GeneOntologyMolecularFunction	kinase activity	TLK1 HK1 MYLK3 PIK3CD CSNK1E PAK5 ROCK1 CARD11 GCK MST1L CDK11B	1.26e-04	764	75	11	GO:0016301
GeneOntologyMolecularFunction	glucokinase activity	HK1 GCK	1.38e-04	5	75	2	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 GCK	1.38e-04	5	75	2	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 GCK	1.38e-04	5	75	2	GO:0008865
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TLK1 HK1 MYLK3 PIK3CD CSNK1E PAK5 ROCK1 POLR1B CARD11 GCK MST1L CDK11B	1.83e-04	938	75	12	GO:0016772
GeneOntologyMolecularFunction	RNA helicase activity	DHX15 DDX46 DDX31 SNRNP200	2.12e-04	78	75	4	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX15 DDX46 DDX31 SNRNP200	2.34e-04	80	75	4	GO:0008186
GeneOntologyMolecularFunction	ATP hydrolysis activity	DHX15 HSP90B1 DDX46 DDX31 ABCB11 SNRNP200 XRCC6 KIFC1	2.46e-04	441	75	8	GO:0016887
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TLK1 HK1 MYLK3 PIK3CD CSNK1E PAK5 ROCK1 GCK MST1L CDK11B	3.08e-04	709	75	10	GO:0016773
GeneOntologyMolecularFunction	helicase activity	DHX15 DDX46 DDX31 SNRNP200 XRCC6	3.22e-04	158	75	5	GO:0004386
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	FRMPD4 GSDMB PLCD1 ASAP1	4.51e-04	95	75	4	GO:0005546
GeneOntologyMolecularFunction	dynein light chain binding	HOOK3 DYNC2I1	8.97e-04	12	75	2	GO:0045503
GeneOntologyMolecularFunction	phospholipid binding	MICALL1 FRMPD4 BCAS3 GSDMB OSBPL10 UNC13C PLCD1 ASAP1	1.03e-03	548	75	8	GO:0005543
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	FRMPD4 GSDMB PLCD1 ASAP1	1.12e-03	121	75	4	GO:1902936
GeneOntologyMolecularFunction	D-glucose binding	HK1 GCK	1.23e-03	14	75	2	GO:0005536
GeneOntologyMolecularFunction	protein kinase activity	TLK1 HK1 MYLK3 CSNK1E PAK5 ROCK1 MST1L CDK11B	1.82e-03	600	75	8	GO:0004672
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DHX15 HSP90B1 DDX46 DDX31 RAB8B ABCB11 SNRNP200 XRCC6 KIFC1	2.43e-03	775	75	9	GO:0017111
GeneOntologyMolecularFunction	phosphatidylserine binding	GSDMB OSBPL10 ASAP1	2.62e-03	73	75	3	GO:0001786
GeneOntologyMolecularFunction	carbohydrate kinase activity	HK1 GCK	2.79e-03	21	75	2	GO:0019200
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DHX15 DDX46 DDX31 MUS81 POLR1B SNRNP200 VARS1 XRCC6	2.85e-03	645	75	8	GO:0140640
GeneOntologyMolecularFunction	lipid binding	MICALL1 NPC1 FRMPD4 BCAS3 GSDMB OSBPL10 GCDH UNC13C PLCD1 ASAP1	3.75e-03	988	75	10	GO:0008289
GeneOntologyMolecularFunction	pyrophosphatase activity	DHX15 HSP90B1 DDX46 DDX31 RAB8B ABCB11 SNRNP200 XRCC6 KIFC1	4.10e-03	839	75	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DHX15 HSP90B1 DDX46 DDX31 RAB8B ABCB11 SNRNP200 XRCC6 KIFC1	4.14e-03	840	75	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DHX15 HSP90B1 DDX46 DDX31 RAB8B ABCB11 SNRNP200 XRCC6 KIFC1	4.14e-03	840	75	9	GO:0016818
GeneOntologyBiologicalProcess	mannose metabolic process	HK1 MAN2B1 GCK	1.07e-05	12	77	3	GO:0006013
Domain	Hexokinase_C	HK1 GCK	1.66e-04	5	77	2	IPR022673
Domain	Hexokinase_N	HK1 GCK	1.66e-04	5	77	2	IPR022672
Domain	Hexokinase_1	HK1 GCK	1.66e-04	5	77	2	PF00349
Domain	Hexokinase_2	HK1 GCK	1.66e-04	5	77	2	PF03727
Domain	HEXOKINASE_2	HK1 GCK	1.66e-04	5	77	2	PS51748
Domain	Hexokinase_BS	HK1 GCK	1.66e-04	5	77	2	IPR019807
Domain	HEXOKINASE_1	HK1 GCK	1.66e-04	5	77	2	PS00378
Domain	DEAD/DEAH_box_helicase_dom	DHX15 DDX46 DDX31 SNRNP200	2.34e-04	73	77	4	IPR011545
Domain	DEAD	DHX15 DDX46 DDX31 SNRNP200	2.34e-04	73	77	4	PF00270
Domain	Hexokinase	HK1 GCK	2.49e-04	6	77	2	IPR001312
Domain	ZF_UBR	UBR5 UBR3	3.48e-04	7	77	2	PS51157
Domain	zf-UBR	UBR5 UBR3	3.48e-04	7	77	2	PF02207
Domain	Znf_UBR	UBR5 UBR3	3.48e-04	7	77	2	IPR003126
Domain	ZnF_UBR1	UBR5 UBR3	3.48e-04	7	77	2	SM00396
Domain	-	OTOF PIK3CD UNC13C PLCD1 SNRNP200	3.65e-04	148	77	5	2.60.40.150
Domain	C2_dom	OTOF PIK3CD UNC13C PLCD1 SNRNP200	5.83e-04	164	77	5	IPR000008
Domain	Helicase_C	DHX15 DDX46 DDX31 SNRNP200	9.99e-04	107	77	4	PF00271
Domain	HELICc	DHX15 DDX46 DDX31 SNRNP200	9.99e-04	107	77	4	SM00490
Domain	Helicase_C	DHX15 DDX46 DDX31 SNRNP200	1.03e-03	108	77	4	IPR001650
Domain	HELICASE_CTER	DHX15 DDX46 DDX31 SNRNP200	1.07e-03	109	77	4	PS51194
Domain	HELICASE_ATP_BIND_1	DHX15 DDX46 DDX31 SNRNP200	1.07e-03	109	77	4	PS51192
Domain	DEXDc	DHX15 DDX46 DDX31 SNRNP200	1.07e-03	109	77	4	SM00487
Domain	Helicase_ATP-bd	DHX15 DDX46 DDX31 SNRNP200	1.11e-03	110	77	4	IPR014001
Domain	PH_dom-like	ASAP2 FRMPD4 OSBPL10 ROCK1 PLCD1 FRMD5 ASAP1	1.86e-03	426	77	7	IPR011993
Domain	PH	ASAP2 OSBPL10 ROCK1 PLCD1 ASAP1	2.56e-03	229	77	5	PF00169
Domain	Ser/Thr_kinase_AS	TLK1 MYLK3 CSNK1E PAK5 ROCK1 CDK11B	3.55e-03	357	77	6	IPR008271
Domain	PROTEIN_KINASE_ST	TLK1 MYLK3 CSNK1E PAK5 ROCK1 CDK11B	3.80e-03	362	77	6	PS00108
Domain	WD40	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	4.33e-03	259	77	5	PF00400
Domain	Pkinase	TLK1 MYLK3 CSNK1E PAK5 ROCK1 CDK11B	4.86e-03	381	77	6	PF00069
Domain	WD40	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	5.00e-03	268	77	5	SM00320
Domain	WD40_repeat	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	5.32e-03	272	77	5	IPR001680
Domain	-	ASAP2 OSBPL10 ROCK1 PLCD1 FRMD5 ASAP1	5.51e-03	391	77	6	2.30.29.30
Domain	PH	ASAP2 OSBPL10 ROCK1 PLCD1 ASAP1	5.82e-03	278	77	5	SM00233
Domain	WD_REPEATS_1	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	5.82e-03	278	77	5	PS00678
Domain	WD_REPEATS_2	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	5.91e-03	279	77	5	PS50082
Domain	WD_REPEATS_REGION	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	5.91e-03	279	77	5	PS50294
Domain	PH_DOMAIN	ASAP2 OSBPL10 ROCK1 PLCD1 ASAP1	5.91e-03	279	77	5	PS50003
Domain	PH_domain	ASAP2 OSBPL10 ROCK1 PLCD1 ASAP1	6.00e-03	280	77	5	IPR001849
Domain	ArfGap	ASAP2 ASAP1	6.34e-03	29	77	2	SM00105
Domain	ArfGap	ASAP2 ASAP1	6.34e-03	29	77	2	PF01412
Domain	ARFGAP	ASAP2 ASAP1	6.34e-03	29	77	2	PS50115
Domain	ArfGAP	ASAP2 ASAP1	6.34e-03	29	77	2	IPR001164
Domain	-	ASAP2 ASAP1	6.77e-03	30	77	2	1.20.1270.60
Domain	AH/BAR-dom	ASAP2 ASAP1	6.77e-03	30	77	2	IPR027267
Domain	Kinase-like_dom	TLK1 MYLK3 PIK3CD CSNK1E PAK5 ROCK1 CDK11B	6.96e-03	542	77	7	IPR011009
Domain	DEAD_ATP_HELICASE	DDX46 DDX31	7.22e-03	31	77	2	PS00039
Domain	WD40_repeat_dom	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	7.65e-03	297	77	5	IPR017986
Domain	P-loop_NTPase	DHX15 DDX46 DDX31 RAB8B ABCB11 CARD11 KIFC3 SNRNP200 KIFC1	8.00e-03	848	77	9	IPR027417
Domain	RNA-helicase_DEAD-box_CS	DDX46 DDX31	8.15e-03	33	77	2	IPR000629
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DHX15 ZNF8 ERCC8 TLK1 DDX46 UBR5 CSNK1E DYNC2I1 CEP76 KIFC3 SNRNP200 NEURL4 XRCC6 WDR43 KIFC1 DCAF7	4.02e-09	1155	77	16	20360068
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	DHX15 HSP90B1 DDX46 FRMPD4 RAB8B MYL6B POLR1B ACTN1 CDK11B SNRNP200 VARS1 XRCC6 WDR43 KIFC1	1.97e-08	949	77	14	36574265
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX15 HSP90B1 DDX46 HOOK3 UBR5 MYL6B ACTN1 SNRNP200 NEURL4 VARS1 XRCC6 GOLGB1 WDR43 KIFC1	5.04e-08	1024	77	14	24711643
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	DHX15 DDX46 ANKRD17 SNRNP200 VARS1 XRCC6 DCAF7	5.21e-07	215	77	7	35973513
Pubmed	A human MAP kinase interactome.	HSP90B1 TLK1 ASAP2 PAK5 ANKRD17 ACTN1 SNRNP200 GOLGB1 ASAP1	1.31e-06	486	77	9	20936779
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	NPC1 DHX15 DDX46 HOOK3 HK1 RAB8B OSBPL10 ANKRD17 ROCK1 ACTN1 VARS1 XRCC6 GOLGB1 ASAP1	1.63e-06	1367	77	14	32687490
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX15 DDX46 DDX31 HK1 UBR5 ANKRD17 ACTN1 SNRNP200 XRCC6 WDR43	1.80e-06	653	77	10	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DHX15 ASAP2 DDX46 UBR5 ANKRD17 GCDH SNRNP200 XRCC6 ASAP1 DCAF7	1.85e-06	655	77	10	35819319
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	NPC1 HSP90B1 DDX46 UBR5 ANKRD17 ACTN1 CDK11B SNRNP200 XRCC6	3.01e-06	538	77	9	28524877
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MICALL1 GRIP1 MYLK3 BCAS3 CSNK1E PAK5 OSBPL10 ANKRD17 PABIR2 GOLGB1 DCAF7	3.03e-06	861	77	11	36931259
Pubmed	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	HK1 ABCB11 GCK	3.73e-06	14	77	3	20858683
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MICALL1 HSP90B1 DDX31 HK1 UBR5 TMEM237 LNPEP CSNK1E CHID1 SNRNP200 NEURL4 XRCC6 GOLGB1 DCAF7	4.31e-06	1487	77	14	33957083
Pubmed	Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.	TGFB3 IRF6	4.84e-06	2	77	2	16245336
Pubmed	Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.	OTOF RAB8B	4.84e-06	2	77	2	18772196
Pubmed	Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.	SCARA5 SCARA3	4.84e-06	2	77	2	22138034
Pubmed	CIN85 interacting proteins in B cells-specific role for SHIP-1.	MICALL1 PIK3CD GCDH ASAP1	6.46e-06	54	77	4	21725061
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DDX46 DDX31 CSNK1E POLR1B SNRNP200 NEURL4 XRCC6 WDR43 KIFC1 DCAF7	6.79e-06	759	77	10	35915203
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	DHX15 HSP90B1 DDX46 HK1 UBR5 ANKRD17 ACTN1 SNRNP200 VARS1 PABIR2 XRCC6 DCAF7	8.10e-06	1149	77	12	35446349
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	DHX15 ZNF8 ABCB11 ACTN1 CHGB SNRNP200 XRCC6	9.38e-06	333	77	7	32665550
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	DHX15 GDA HSP90B1 ASAP2 HK1 RAB8B ROCK1 ACTN1 ASAP1	9.54e-06	621	77	9	22794259
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DHX15 HSP90B1 DDX31 ACTN1 CDK11B SNRNP200 VARS1 XRCC6 WDR43 KIFC1 DCAF7	1.12e-05	989	77	11	36424410
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	DHX15 UBR5 MYL6B ANKRD17 CEP76 SNRNP200 NEURL4 XRCC6 DCAF7	1.20e-05	639	77	9	23443559
Pubmed	IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion.	TGFB3 IRF6	1.45e-05	3	77	2	26240017
Pubmed	Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.	DHX15 MAN2B1	1.45e-05	3	77	2	24383474
Pubmed	FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.	ROCK1 FRMD5	1.45e-05	3	77	2	25448675
Pubmed	Taking the next step forward - Diagnosing inherited infantile cholestatic disorders with next generation sequencing.	NPC1 ABCB11	1.45e-05	3	77	2	25771912
Pubmed	A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.	OTOF ACTN1	1.45e-05	3	77	2	26568308
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	DHX15 HSP90B1 DDX46 UBR5 MUS81 SNRNP200 VARS1	1.47e-05	357	77	7	37059091
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	DHX15 HSP90B1 HK1 SNRNP200 XRCC6 KIFC1	1.56e-05	239	77	6	26641092
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX15 HSP90B1 CSNK1E MYL6B ANKRD17 POLR1B ACTN1 SNRNP200 XRCC6 WDR43 KIFC1 DCAF7	1.98e-05	1257	77	12	36526897
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DHX15 DDX46 CDK11B SNRNP200 XRCC6	2.44e-05	154	77	5	16055720
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MICALL1 DHX15 GRIP1 HSP90B1 ANKRD17 ROCK1 SNRNP200 XRCC6 GOLGB1	2.68e-05	708	77	9	39231216
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	NPC1 DHX15 GDA HSP90B1 MAN2B1 UBR5 LNPEP GCDH CHID1 SCARA3 XRCC6 DCAF7	2.69e-05	1297	77	12	33545068
Pubmed	Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.	OTOF RAB8B	2.89e-05	4	77	2	17055430
Pubmed	Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.	ASAP2 ASAP1	2.89e-05	4	77	2	12149250
Pubmed	Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8.	MAN2B1 GCDH	2.89e-05	4	77	2	8829553
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	ASAP2 GOLGB1 ASAP1	2.94e-05	27	77	3	18685082
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MICALL1 NPC1 TLK1 MAN2B1 TMEM94 BCAS3 PIK3CD MUS81 MIB2 KIFC3 SCARA3	3.11e-05	1105	77	11	35748872
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX15 HSP90B1 DDX46 DDX31 POLR1B GCDH CDK11B SNRNP200 VARS1 XRCC6 WDR43 DCAF7	3.15e-05	1318	77	12	30463901
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MICALL1 TLK1 ASAP2 TMEM237 MYL6B DYNC2I1 CEP76 ACTN1 SNRNP200 NEURL4 PABIR2 DCAF7	3.22e-05	1321	77	12	27173435
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	NPC1 HSP90B1 MAN2B1 LNPEP SCARA5	3.29e-05	164	77	5	32409323
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	MICALL1 XRCC6 ASAP1	4.49e-05	31	77	3	19041431
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DHX15 DDX46 DDX31 TMEM237 MYL6B PCDHAC2 ANKRD17 CDK11B VARS1 XRCC6 WDR43 DCAF7	4.61e-05	1371	77	12	36244648
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	GRIP1 UBR5 CSNK1E DYNC2I1 MIB2 ACTN1 DCAF7	4.80e-05	430	77	7	32581705
Pubmed	Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.	ABCB11 GCK	4.82e-05	5	77	2	19937311
Pubmed	Standardizing scavenger receptor nomenclature.	SCARA5 SCARA3	4.82e-05	5	77	2	24563502
Pubmed	The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.	MICALL1 RAB8B	4.82e-05	5	77	2	18094055
Pubmed	Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.	ABCB11 XRCC6	4.82e-05	5	77	2	19833092
Pubmed	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	HK1 GCK	4.82e-05	5	77	2	19096518
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GDA HOOK3 UBR5 PAK5 ANKRD17 ROCK1 NEURL4 XRCC6 GOLGB1 DCAF7	5.18e-05	963	77	10	28671696
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	NPC1 DHX15 HSP90B1 MAN2B1 LNPEP GCDH SNRNP200 VARS1	6.43e-05	613	77	8	22268729
Pubmed	Subunit composition of the human cytoplasmic dynein-2 complex.	DYNC2I1 GOLGB1	7.22e-05	6	77	2	25205765
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	ASAP2 ASAP1	7.22e-05	6	77	2	18786926
Pubmed	Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.	DHX15 SNRNP200	7.22e-05	6	77	2	22569250
Pubmed	Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.	CEP76 NEURL4	7.22e-05	6	77	2	22441691
Pubmed	Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).	FRMPD4 GPSM1	7.22e-05	6	77	2	22074847
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ERCC8 HSP90B1 UBR5 OSBPL10 ANKRD17 POLR1B SNRNP200 NEURL4 VARS1 PABIR2	7.38e-05	1005	77	10	19615732
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	DHX15 UBR5 PAK5 ROCK1 POLR1B XRCC6	7.53e-05	317	77	6	17620599
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	HSP90B1 UBR5 SNRNP200 VARS1 XRCC6	7.87e-05	197	77	5	31620119
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	DHX15 HSP90B1 HK1 ACTN1 SNRNP200 XRCC6	8.93e-05	327	77	6	31409639
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZNF8 EPC2 MUS81 ROCK1 CEP76 XRCC6 KIFC1 DCAF7	9.16e-05	645	77	8	25281560
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ASAP2 PIK3CD RAB8B POLR1B GCDH ASAP1	9.23e-05	329	77	6	17474147
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	DDX46 UBR5 GCDH MIB2 ACTN1 NEURL4 XRCC6	9.67e-05	481	77	7	28190767
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DHX15 HSP90B1 HK1 UBR5 CSNK1E POLR1B GCDH SNRNP200 VARS1 XRCC6 DCAF7	9.88e-05	1257	77	11	37317656
Pubmed	ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.	ASAP2 ASAP1	1.01e-04	7	77	2	9819391
Pubmed	Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.	UBR5 CEP76	1.01e-04	7	77	2	28242748
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	ASAP2 ASAP1	1.01e-04	7	77	2	17255943
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	HK1 GCK	1.01e-04	7	77	2	18165236
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	HSP90B1 ASAP2 ANKRD17 CARD11 GOLGB1	1.02e-04	208	77	5	33230847
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MICALL1 GRIP1 HOOK3 UBR5 CSNK1E MYL6B DYNC2I1 NEURL4 ASAP1	1.12e-04	853	77	9	28718761
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	DHX15 HSP90B1 SNRNP200 VARS1 XRCC6 KIFC1 DCAF7	1.14e-04	494	77	7	26831064
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DHX15 DDX46 SNRNP200 XRCC6 DCAF7	1.32e-04	220	77	5	35785414
Pubmed	Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.	ASAP2 ASAP1	1.34e-04	8	77	2	15719014
Pubmed	Molecular genetic markers spanning mouse chromosome 10.	HSP90B1 HK1	1.34e-04	8	77	2	1981053
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	OTOF UNC13C	1.34e-04	8	77	2	25609709
Pubmed	TGFβ3 regulates periderm removal through ΔNp63 in the developing palate.	TGFB3 IRF6	1.34e-04	8	77	2	25358290
Pubmed	The protein interaction landscape of the human CMGC kinase group.	DHX15 DDX46 TMEM94 ROCK1 SNRNP200 NEURL4 VARS1 DCAF7	1.53e-04	695	77	8	23602568
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	DDX46 OTOF GSDMB CARD11 MIB2 SCARA3	1.53e-04	361	77	6	26167880
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DHX15 EPC2 TLK1 UBR5 ACTN1 SNRNP200 VARS1 XRCC6 KIFC1 DCAF7	1.58e-04	1103	77	10	34189442
Pubmed	Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.	GRIP1 GDA	1.72e-04	9	77	2	20877300
Pubmed	Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.	FMN1 IRF6	1.72e-04	9	77	2	20023658
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR5 UBR3	1.72e-04	9	77	2	17855541
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DHX15 OTOF SNRNP200 VARS1 GOLGB1	1.76e-04	234	77	5	36243803
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	ASAP2 DDX46 UBR5 SNRNP200 XRCC6	1.79e-04	235	77	5	30258100
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX15 HSP90B1 HK1 UBR5 ANKRD17 POLR1B ACTN1 SNRNP200 VARS1 XRCC6 ASAP1	1.88e-04	1353	77	11	29467282
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	HSP90B1 HK1 ACTN1 VARS1	2.10e-04	131	77	4	28634551
Pubmed	Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.	TGFB3 IRF6	2.15e-04	10	77	2	19439425
Pubmed	Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits.	BCAS3 PAK5	2.15e-04	10	77	2	19139271
Pubmed	Multiple functions of Snail family genes during palate development in mice.	TGFB3 IRF6	2.15e-04	10	77	2	17376812
Pubmed	Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach.	DHX15 HSP90B1	2.15e-04	10	77	2	30855574
Pubmed	Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.	HK1 GCK	2.15e-04	10	77	2	37545422
Pubmed	MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.	ROCK1 ACTN1	2.15e-04	10	77	2	18332105
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	DHX15 HSP90B1 ASAP2 DDX46 RAB8B MYL6B CDK11B SNRNP200 VARS1 XRCC6	2.26e-04	1153	77	10	29845934
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	DHX15 DDX46 UBR5 ROCK1 CDK11B SNRNP200	2.32e-04	390	77	6	17643375
Pubmed	Defining the membrane proteome of NK cells.	NPC1 HSP90B1 UBR5 TMEM237 LNPEP ANKRD17 CHID1 XRCC6 GOLGB1 KIFC1	2.50e-04	1168	77	10	19946888
Pubmed	Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion.	TGFB3 IRF6	2.63e-04	11	77	2	18470539
Pubmed	Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.	ROBO4 ACTN1	2.63e-04	11	77	2	24355925
Pubmed	A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.	TGFB3 IRF6	2.63e-04	11	77	2	15361870
Pubmed	Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.	GRIP1 ABCB11	2.63e-04	11	77	2	15471871
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	MICALL1 ASAP2 ROCK1 POLR1B ACTN1 KIFC1	2.66e-04	400	77	6	35013556
Interaction	TNIP1 interactions	DHX15 HSP90B1 DDX46 FRMPD4 PIK3CD RAB8B MYL6B POLR1B CARD11 ACTN1 CDK11B KIFC3 SNRNP200 VARS1 XRCC6 WDR43 KIFC1	2.62e-06	1217	77	17	int:TNIP1
Cytoband	14q24	TGFB3 ACTN1	1.51e-04	11	77	2	14q24
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR5 UBR3	1.75e-04	7	53	2	785
GeneFamily	WD repeat domain containing	ERCC8 BCAS3 DYNC2I1 WDR43 DCAF7	1.00e-03	262	53	5	362
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP2 ASAP1	1.11e-03	17	53	2	1291
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SCARA5 SCARA3	2.82e-03	27	53	2	1253
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP2 OSBPL10 ROCK1 ASAP1	3.10e-03	206	53	4	682
GeneFamily	ArfGAPs	ASAP2 ASAP1	4.20e-03	33	53	2	395
GeneFamily	Ankyrin repeat domain containing	ASAP2 ANKRD17 MIB2 ASAP1	5.49e-03	242	53	4	403
GeneFamily	DEAD-box helicases	DDX46 DDX31	6.73e-03	42	53	2	499
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIFC3 KIFC1	8.04e-03	46	53	2	622
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMPD4 FRMD5	9.44e-03	50	53	2	1293
GeneFamily	PDZ domain containing	GRIP1 FRMPD4 CARD11	1.00e-02	152	53	3	1220
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	DHX15 GRIP1 HSP90B1 PIK3CD ANKRD17 VARS1 ASAP1 DCAF7	1.83e-09	196	77	8	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 GDA OSBPL10 KIFC3 FAM135B FRMD5	8.56e-07	186	77	6	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF8 GDA MYL6B ACTN1 XRCC6	3.36e-06	132	77	5	9936078c328b1e1d59f9dfdd69d36926a0cdaf0d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 GDA OSBPL10 FAM135B FRMD5	1.92e-05	189	77	5	28b502611829e4a24caff2562545c7db97686099
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GDA OSBPL10 KIFC3 FAM135B FRMD5	1.97e-05	190	77	5	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	NPC1 DHX15 HSP90B1 DDX46 RAB8B	2.02e-05	191	77	5	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 CDH22 OSBPL10 KIFC3 FAM135B	2.02e-05	191	77	5	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	Caecum-T_cell-Th1\|T_cell / Region, Cell class and subclass	GRIP1 TMEM237 OSBPL10 PTGER2 GOLGB1	2.46e-05	199	77	5	13a80e6d3cf9c831edbe0644545071153e35f82b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	GRIP1 UBR5 BCAS3 OSBPL10 UBR3	2.46e-05	199	77	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Computational	Genes in the cancer module 262.	DHX15 RAB8B MUS81 PTGER2 SNRNP200	1.52e-04	100	55	5	MODULE_261
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A	MICALL1 ZNF8 TGFB3 ERCC8 KIFC3 PTGER2 SCARA3	4.70e-06	197	77	7	1810_DN
Drug	Cimetidine [51481-61-9]; Up 200; 15.8uM; HL60; HG-U133A	ERCC8 DDX31 ANKRD17 PLCD1 CEP76 ACTN1 ASAP1	5.03e-06	199	77	7	1964_UP
Drug	monoethyl succinate	HK1 GCK	1.13e-05	2	77	2	CID000070610
Disease	glucose metabolism disease (implicated_via_orthology)	HK1 PIK3CD GCK	4.74e-05	28	74	3	DOID:4194 (implicated_via_orthology)
Disease	fructosamine measurement	ABCB11 GCK	1.29e-04	7	74	2	EFO_0009303
Disease	invasive ductal carcinoma (is_implicated_in)	UBR5 CSNK1E	3.36e-04	11	74	2	DOID:3008 (is_implicated_in)
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	UBR5 PIK3CD	7.28e-04	16	74	2	C0334634
Disease	behavioural disinhibition measurement	SCARA5 UNC13C ACTN1	8.98e-04	75	74	3	EFO_0006946
Disease	alcohol consumption measurement	MICALL1 NPC1 DHX15 GRIP1 DDX31 RAB8B ACTN1 FAM135B FRMD5 WDR43	1.04e-03	1242	74	10	EFO_0007878
Disease	platelet measurement	MICALL1 ERCC8 DYNC2I1 ACTN1 ASAP1	1.19e-03	315	74	5	EFO_0005036
Disease	Ataxia	NPC1 HK1	1.79e-03	25	74	2	C0004134
Disease	Adenocarcinoma of lung (disorder)	HK1 CSNK1E PAK5 XRCC6	1.81e-03	206	74	4	C0152013
Disease	neuritic plaque measurement	TLK1 CDH22 OSBPL10 GRIK4 FAM135B	1.86e-03	349	74	5	EFO_0006798
Disease	factor VIII measurement, von Willebrand factor measurement	DDX31 SCARA5	2.09e-03	27	74	2	EFO_0004629, EFO_0004630
Disease	type 2 diabetes mellitus (implicated_via_orthology)	LNPEP PIK3CD GCK	2.36e-03	105	74	3	DOID:9352 (implicated_via_orthology)
Disease	suicidal ideation	GRIP1 GDA	2.41e-03	29	74	2	EFO_0004320
Disease	periodontitis	OTOF OSBPL10 ACTN1 FAM135B	2.42e-03	223	74	4	EFO_0000649
Disease	pulse pressure measurement	NPC1 DHX15 EPC2 ASAP2 IQCH ABCB11 UBR3 GCK CDK11B XRCC6	2.43e-03	1392	74	10	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVGDRLETDILFGHR	BARGIN	616	Q6ZT62
RGGRVIMDRISTEHD	EPC2	456	Q52LR7
EEIGRISIEMHGTLE	ACTN1	651	P12814
RVSEVLISGELHMED	GSDMB	296	Q8TAX9
EGMVTVDGHDIRSLN	ABCB11	476	O95342
DSLEEGELRDHRMEI	CDK11B	46	P21127
LEVHRESLGDGTRMA	CEP76	166	Q8TAP6
LMEAGSAGHVEVARL	ANKRD17	371	O75179
EAHERTLATDILMGV	DHX15	261	O43143
MEHTEEGLRERLADA	BCAS3	851	Q9H6U6
GADGSVRMFDLRHLE	DCAF7	196	P61962
IEEHASSDVERMILG	RAB8B	106	Q92930
IRGEHAMITARLEET	FMN1	751	Q68DA7
VSGLLHRDDLAVADM	IQCH	576	Q86VS3
MDRGLRLETHEEASV	GCK	41	P35557
LEGGALTDIVTHTRM	PAK5	526	Q9P286
RGHVRESEMCTEGLL	MST1L	641	Q2TV78
HDLLLARTIGDRMGE	GPSM1	91	Q86YR5
EIGDRHGELTARMNV	GPSM1	361	Q86YR5
HGMIRTEISGAEIAE	ASAP2	171	O43150
DMGLISHGTRQDLRV	DYNC2I1	881	Q8WVS4
ALLTEREERLHGLEM	KIFC1	281	Q9BW19
DMGHLERGLHRLEAS	MYLK3	56	Q32MK0
GERVSMAEETDHLIL	PTGER2	251	P43116
SRLLVRGLGEHEMEE	LNPEP	51	Q9UIQ6
GEMDTIERRLDALEH	MICALL1	686	Q8N3F8
LRLHGGMEQEERTAV	DDX31	556	Q9H8H2
IGEHSDAAELGRMLQ	HOOK3	106	Q86VS8
ELRHIDLVEGDEGRM	HK1	241	P19367
DGLHLLTVGTDNRMR	ERCC8	256	Q13216
RHSLEEGLDMVNRET	PABIR2	56	Q7Z309
DIQEVRMGHRTEGLE	PLCD1	71	P51178
GSRVERAEEALAHMG	NPC1	1181	O15118
ELHTGEIRTTRKMGD	PCDHAC2	636	Q9Y5I4
HVTDTGVGMTREELV	HSP90B1	146	P14625
AVHISIMEGLESLRD	FRMD5	371	Q7Z6J6
VFHREIISEMGELGV	GCDH	91	Q92947
GIEHFSLMLEQRTEG	FRMPD4	241	Q14CM0
HGMIRTEITGAEIAE	ASAP1	191	Q9ULH1
GSSLRDGSLELMVHR	MAN2B1	801	O00754
MEVLRDHLLGVSDSG	GDA	26	Q9Y2T3
LIDELTGDIHAMERL	CDH22	111	Q9UJ99
VHLLLGGERMEDALS	FAM135B	91	Q49AJ0
FRHIMDQRSLEEGEG	DDX46	431	Q7L014
LRMVELEGLTGHIEF	GRIK4	351	Q16099
VDGIRLLGTTHAEAM	GRIP1	206	Q9Y3R0
ELGSLASIDREIAMH	PRDM13	511	Q9H4Q3
LEGRMASHEIEIGTI	SCARA3	346	Q6AZY7
SEDTRRLRLAHVGME	SCARA5	256	Q6ZMJ2
MSDTREEKRFLGEGH	CHGB	431	P05060
LQRLMHRGSREEVDG	CARD11	846	Q9BXL7
RGREMFEVTGLHDVD	CHID1	116	Q9BWS9
RRGADDTMHILVDGE	NEURL4	1041	Q96JN8
EMEDLDHLAIRLGDG	OTOF	201	Q9HC10
LLDTDVLREMQEGHG	MIB2	266	Q96AX9
DVMDRGLILEVSGHA	IRF6	296	O14896
RHGLEAISIMDSRGA	VARS1	606	P26640
ELGGTDLEKHRDLLM	KIFC3	126	Q9BVG8
ADMLDILSHTRGEAV	SPPL2C	156	Q8IUH8
SMIGEGVLRLLEHGE	OSBPL10	571	Q9BXB5
LEDMEVSHTQRLGRG	ROBO4	961	Q8WZ75
MRTDSGARLEEGHLR	TMEM237	1	Q96Q45
SGRPREGAMDELHSL	TLK1	41	Q9UKI8
GDLRDTGIFLDLMHL	XRCC6	191	P12956
EDVSMEFLHGALGRD	UNC13C	1701	Q8NB66
VMGAELRHVLTTLGE	MYL6B	161	P14649
EGLLLMEEEGHSDLI	TMEM94	916	Q12767
IGDRHSDNIMIRESG	PIK3CD	891	O00329
EAERRDRGHDSEMIG	ROCK1	611	Q13464
DRGHDSEMIGDLQAR	ROCK1	616	Q13464
HAGMTRVDRTLVEDL	SNRNP200	786	O75643
RLHLGMSDDEILRAE	UBR3	776	Q6ZT12
RDVMLETFGHLLSIG	ZNF8	51	P17098
RFGEMERDALLAHGT	POLR1B	1036	Q9H9Y6
TRELLEEMHGEREEG	TGFB3	76	P10600
MELIIAHGRENGADS	UBR5	2446	O95071
VSIEERLGAMDIDTH	WDR43	436	Q15061
EIRGLRSHMDDLNSE	GOLGB1	2511	Q14789
HEREERMGQLRGSAT	CSNK1E	311	P49674
MLDERLQRHRTSGGD	MUS81	76	Q96NY9