| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | ubiquitin conjugating enzyme activity | 1.45e-07 | 37 | 26 | 4 | GO:0061631 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein conjugating enzyme activity | 2.69e-07 | 43 | 26 | 4 | GO:0061650 | |
| GeneOntologyMolecularFunction | ubiquitin-protein transferase activity | 2.63e-05 | 473 | 26 | 6 | GO:0004842 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein transferase activity | 4.11e-05 | 512 | 26 | 6 | GO:0019787 | |
| GeneOntologyMolecularFunction | aminoacyltransferase activity | 5.08e-05 | 532 | 26 | 6 | GO:0016755 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase binding | 6.53e-05 | 337 | 26 | 5 | GO:0031625 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase binding | 8.69e-05 | 358 | 26 | 5 | GO:0044389 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase activity | 1.04e-04 | 372 | 26 | 5 | GO:0061630 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase activity | 1.43e-04 | 398 | 26 | 5 | GO:0061659 | |
| GeneOntologyMolecularFunction | acyltransferase activity | 3.96e-04 | 775 | 26 | 6 | GO:0016746 | |
| GeneOntologyBiologicalProcess | protein K29-linked ubiquitination | 1.41e-09 | 13 | 26 | 4 | GO:0035519 | |
| GeneOntologyBiologicalProcess | protein K48-linked ubiquitination | 1.47e-07 | 100 | 26 | 5 | GO:0070936 | |
| GeneOntologyBiologicalProcess | protein K27-linked ubiquitination | 6.41e-07 | 14 | 26 | 3 | GO:0044314 | |
| GeneOntologyBiologicalProcess | protein K6-linked ubiquitination | 1.19e-06 | 17 | 26 | 3 | GO:0085020 | |
| GeneOntologyBiologicalProcess | protein K11-linked ubiquitination | 1.34e-05 | 37 | 26 | 3 | GO:0070979 | |
| GeneOntologyBiologicalProcess | protein polyubiquitination | 2.70e-05 | 289 | 26 | 5 | GO:0000209 | |
| GeneOntologyBiologicalProcess | protein K63-linked ubiquitination | 1.18e-04 | 76 | 26 | 3 | GO:0070534 | |
| GeneOntologyBiologicalProcess | ubiquitin-dependent protein catabolic process | 1.18e-04 | 640 | 26 | 6 | GO:0006511 | |
| GeneOntologyBiologicalProcess | modification-dependent protein catabolic process | 1.30e-04 | 651 | 26 | 6 | GO:0019941 | |
| GeneOntologyBiologicalProcess | modification-dependent macromolecule catabolic process | 1.35e-04 | 656 | 26 | 6 | GO:0043632 | |
| GeneOntologyBiologicalProcess | protein catabolic process | 3.51e-04 | 1115 | 26 | 7 | GO:0030163 | |
| GeneOntologyBiologicalProcess | protein ubiquitination | 4.25e-04 | 811 | 26 | 6 | GO:0016567 | |
| GeneOntologyBiologicalProcess | proteolysis involved in protein catabolic process | 4.28e-04 | 812 | 26 | 6 | GO:0051603 | |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation | 7.08e-04 | 893 | 26 | 6 | GO:0032446 | |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation or removal | 1.34e-03 | 1009 | 26 | 6 | GO:0070647 | |
| GeneOntologyCellularComponent | ubiquitin ligase complex | 8.81e-04 | 352 | 26 | 4 | GO:0000151 | |
| GeneOntologyCellularComponent | transferase complex | 9.80e-04 | 963 | 26 | 6 | GO:1990234 | |
| GeneOntologyCellularComponent | intracellular protein-containing complex | 1.03e-03 | 972 | 26 | 6 | GO:0140535 | |
| Domain | UBQ-conjugating_AS | 2.17e-08 | 25 | 23 | 4 | IPR023313 | |
| Domain | UQ_con | 1.40e-07 | 39 | 23 | 4 | PF00179 | |
| Domain | UBIQUITIN_CONJUGAT_1 | 1.55e-07 | 40 | 23 | 4 | PS00183 | |
| Domain | UBIQUITIN_CONJUGAT_2 | 1.72e-07 | 41 | 23 | 4 | PS50127 | |
| Domain | UBQ-conjugat_E2 | 1.72e-07 | 41 | 23 | 4 | IPR000608 | |
| Domain | - | 4.20e-07 | 51 | 23 | 4 | 3.10.110.10 | |
| Domain | UBQ-conjugating_enzyme/RWD | 4.92e-07 | 53 | 23 | 4 | IPR016135 | |
| Domain | G_patch | 3.61e-04 | 23 | 23 | 2 | SM00443 | |
| Domain | G_patch_dom | 3.61e-04 | 23 | 23 | 2 | IPR000467 | |
| Domain | G-patch | 3.61e-04 | 23 | 23 | 2 | PF01585 | |
| Domain | G_PATCH | 3.61e-04 | 23 | 23 | 2 | PS50174 | |
| Domain | HECT | 5.00e-04 | 27 | 23 | 2 | PF00632 | |
| Domain | HECTc | 5.00e-04 | 27 | 23 | 2 | SM00119 | |
| Domain | HECT_dom | 5.00e-04 | 27 | 23 | 2 | IPR000569 | |
| Domain | HECT | 5.00e-04 | 27 | 23 | 2 | PS50237 | |
| Domain | PSI | 1.33e-03 | 44 | 23 | 2 | IPR016201 | |
| Domain | PSI | 1.45e-03 | 46 | 23 | 2 | SM00423 | |
| Domain | ZF_C3H1 | 2.30e-03 | 58 | 23 | 2 | PS50103 | |
| Domain | Rho_GTPase_activation_prot | 5.21e-03 | 88 | 23 | 2 | IPR008936 | |
| Domain | TPR-contain_dom | 1.45e-02 | 150 | 23 | 2 | IPR013026 | |
| Pathway | KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS | 1.69e-08 | 135 | 19 | 6 | M15247 | |
| Pathway | PID_ERBB1_INTERNALIZATION_PATHWAY | 2.31e-07 | 41 | 19 | 4 | M214 | |
| Pathway | REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING | 1.67e-06 | 18 | 19 | 3 | MM15680 | |
| Pathway | REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT | 1.98e-06 | 19 | 19 | 3 | M27020 | |
| Pathway | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | 2.21e-06 | 308 | 19 | 6 | M1070 | |
| Pathway | REACTOME_SIGNALING_BY_CSF3_G_CSF | 3.15e-06 | 22 | 19 | 3 | MM15675 | |
| Pathway | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | 3.61e-06 | 23 | 19 | 3 | M1003 | |
| Pathway | REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING | 4.69e-06 | 25 | 19 | 3 | M41829 | |
| Pathway | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | 4.69e-06 | 25 | 19 | 3 | MM15646 | |
| Pathway | REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION | 7.54e-06 | 381 | 19 | 6 | M1066 | |
| Pathway | REACTOME_SIGNALING_BY_CSF3_G_CSF | 8.24e-06 | 30 | 19 | 3 | M41825 | |
| Pathway | REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING | 1.32e-05 | 35 | 19 | 3 | M985 | |
| Pathway | REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS | 2.84e-05 | 45 | 19 | 3 | MM15508 | |
| Pathway | REACTOME_REGULATION_OF_TNFR1_SIGNALING | 3.24e-05 | 47 | 19 | 3 | MM15179 | |
| Pathway | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | 3.78e-05 | 299 | 19 | 5 | MM15711 | |
| Pathway | REACTOME_TNF_SIGNALING | 5.50e-05 | 56 | 19 | 3 | MM15453 | |
| Pathway | WP_PROTEASOME_DEGRADATION | 5.50e-05 | 56 | 19 | 3 | MM15901 | |
| Pathway | REACTOME_TNF_SIGNALING | 5.80e-05 | 57 | 19 | 3 | M27713 | |
| Pathway | REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS | 6.43e-05 | 59 | 19 | 3 | M27763 | |
| Pathway | REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION | 7.27e-05 | 343 | 19 | 5 | MM15712 | |
| Pathway | WP_PROTEASOME_DEGRADATION | 7.47e-05 | 62 | 19 | 3 | M39639 | |
| Pathway | REACTOME_PEROXISOMAL_PROTEIN_IMPORT | 7.83e-05 | 63 | 19 | 3 | M27915 | |
| Pathway | REACTOME_PROTEIN_UBIQUITINATION | 8.60e-05 | 65 | 19 | 3 | MM15490 | |
| Pathway | REACTOME_PEROXISOMAL_PROTEIN_IMPORT | 8.60e-05 | 65 | 19 | 3 | MM15628 | |
| Pathway | REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA | 1.03e-04 | 69 | 19 | 3 | MM14522 | |
| Pathway | REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA | 1.32e-04 | 75 | 19 | 3 | M641 | |
| Pathway | REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX | 1.43e-04 | 77 | 19 | 3 | MM14670 | |
| Pathway | REACTOME_PROTEIN_UBIQUITINATION | 1.54e-04 | 79 | 19 | 3 | M27742 | |
| Pathway | REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA | 1.72e-04 | 82 | 19 | 3 | M1002 | |
| Pathway | REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX | 2.57e-04 | 94 | 19 | 3 | M1041 | |
| Pathway | REACTOME_PROTEIN_LOCALIZATION | 3.37e-04 | 103 | 19 | 3 | MM15653 | |
| Pathway | REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE | 3.98e-04 | 109 | 19 | 3 | M29565 | |
| Pathway | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | 4.67e-04 | 24 | 19 | 2 | MM14877 | |
| Pathway | REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS | 5.02e-04 | 118 | 19 | 3 | MM15588 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE | 5.54e-04 | 122 | 19 | 3 | MM14640 | |
| Pathway | REACTOME_ADAPTIVE_IMMUNE_SYSTEM | 5.65e-04 | 828 | 19 | 6 | M1058 | |
| Pathway | REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES | 7.32e-04 | 30 | 19 | 2 | M27762 | |
| Pathway | REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES | 7.32e-04 | 30 | 19 | 2 | MM15507 | |
| Pathway | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | 7.82e-04 | 31 | 19 | 2 | M669 | |
| Pathway | REACTOME_SIGNALING_BY_BMP | 7.82e-04 | 31 | 19 | 2 | M1662 | |
| Pathway | REACTOME_SIGNALING_BY_BMP | 7.82e-04 | 31 | 19 | 2 | MM14789 | |
| Pathway | REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY | 8.33e-04 | 32 | 19 | 2 | M27419 | |
| Pathway | REACTOME_DEATH_RECEPTOR_SIGNALING | 8.61e-04 | 142 | 19 | 3 | MM15431 | |
| Pathway | REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY | 9.41e-04 | 34 | 19 | 2 | MM15167 | |
| Pathway | REACTOME_DEATH_RECEPTOR_SIGNALING | 1.09e-03 | 154 | 19 | 3 | M27697 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 1.11e-03 | 155 | 19 | 3 | MM14665 | |
| Pathway | REACTOME_MITOPHAGY | 1.24e-03 | 39 | 19 | 2 | M27418 | |
| Pathway | REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS | 1.24e-03 | 161 | 19 | 3 | M27871 | |
| Pathway | REACTOME_PROTEIN_LOCALIZATION | 1.31e-03 | 164 | 19 | 3 | M27932 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER | 1.37e-03 | 41 | 19 | 2 | MM14876 | |
| Pathway | REACTOME_MITOPHAGY | 1.37e-03 | 41 | 19 | 2 | MM15166 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 1.45e-03 | 170 | 19 | 3 | M7494 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER | 2.11e-03 | 51 | 19 | 2 | M665 | |
| Pathway | REACTOME_ADAPTIVE_IMMUNE_SYSTEM | 2.18e-03 | 719 | 19 | 5 | MM14540 | |
| Pathway | REACTOME_NEDDYLATION | 3.26e-03 | 226 | 19 | 3 | MM15543 | |
| Pathway | REACTOME_NEDDYLATION | 4.09e-03 | 245 | 19 | 3 | M27822 | |
| Pathway | REACTOME_SELECTIVE_AUTOPHAGY | 4.27e-03 | 73 | 19 | 2 | MM15672 | |
| Pathway | WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR | 5.23e-03 | 81 | 19 | 2 | M39490 | |
| Pathway | REACTOME_SELECTIVE_AUTOPHAGY | 6.42e-03 | 90 | 19 | 2 | M29841 | |
| Pathway | REACTOME_CLEC7A_DECTIN_1_SIGNALING | 6.84e-03 | 93 | 19 | 2 | MM15204 | |
| Pathway | REACTOME_DOWNSTREAM_TCR_SIGNALING | 6.84e-03 | 93 | 19 | 2 | MM14806 | |
| Pathway | REACTOME_CLEC7A_DECTIN_1_SIGNALING | 7.88e-03 | 100 | 19 | 2 | M27467 | |
| Pathway | REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION | 8.97e-03 | 107 | 19 | 2 | MM14915 | |
| Pubmed | Autoregulation of the 26S proteasome by in situ ubiquitination. | 1.79e-12 | 19 | 26 | 5 | 24743594 | |
| Pubmed | The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. | 8.57e-12 | 7 | 26 | 4 | 21685362 | |
| Pubmed | 8.57e-12 | 7 | 26 | 4 | 30884854 | ||
| Pubmed | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. | 1.01e-11 | 26 | 26 | 5 | 26949039 | |
| Pubmed | Ube2W conjugates ubiquitin to α-amino groups of protein N-termini. | 1.71e-11 | 8 | 26 | 4 | 23560854 | |
| Pubmed | 1.71e-11 | 8 | 26 | 4 | 29323787 | ||
| Pubmed | 5.14e-11 | 10 | 26 | 4 | 28757353 | ||
| Pubmed | 5.14e-11 | 10 | 26 | 4 | 31087003 | ||
| Pubmed | The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. | 1.21e-10 | 12 | 26 | 4 | 24211586 | |
| Pubmed | Ubiquitination of STING at lysine 224 controls IRF3 activation. | 1.75e-10 | 13 | 26 | 4 | 28763789 | |
| Pubmed | 2.44e-10 | 14 | 26 | 4 | 36481767 | ||
| Pubmed | Identification of a family of closely related human ubiquitin conjugating enzymes. | 3.71e-10 | 3 | 26 | 3 | 8530467 | |
| Pubmed | Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations. | 4.44e-10 | 16 | 26 | 4 | 25723849 | |
| Pubmed | 5.80e-10 | 17 | 26 | 4 | 33650289 | ||
| Pubmed | 5.80e-10 | 17 | 26 | 4 | 36563856 | ||
| Pubmed | 9.44e-10 | 19 | 26 | 4 | 27425610 | ||
| Pubmed | Physical and functional interactions between ZIP kinase and UbcH5. | 1.48e-09 | 4 | 26 | 3 | 18515077 | |
| Pubmed | The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway. | 2.15e-09 | 23 | 26 | 4 | 30017913 | |
| Pubmed | Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes. | 2.58e-09 | 24 | 26 | 4 | 34195792 | |
| Pubmed | 2.58e-09 | 24 | 26 | 4 | 24647965 | ||
| Pubmed | The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. | 3.63e-09 | 26 | 26 | 4 | 20061386 | |
| Pubmed | Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. | 3.70e-09 | 5 | 26 | 3 | 25327252 | |
| Pubmed | Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. | 3.70e-09 | 5 | 26 | 3 | 23509263 | |
| Pubmed | The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. | 3.70e-09 | 5 | 26 | 3 | 14562029 | |
| Pubmed | E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). | 3.70e-09 | 5 | 26 | 3 | 15684077 | |
| Pubmed | Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. | 3.70e-09 | 5 | 26 | 3 | 26502057 | |
| Pubmed | 3.70e-09 | 5 | 26 | 3 | 23408431 | ||
| Pubmed | 3.70e-09 | 5 | 26 | 3 | 31929179 | ||
| Pubmed | 3.70e-09 | 5 | 26 | 3 | 19741096 | ||
| Pubmed | 3.70e-09 | 5 | 26 | 3 | 16413270 | ||
| Pubmed | 3.70e-09 | 5 | 26 | 3 | 8090726 | ||
| Pubmed | Functional interactions between ubiquitin E2 enzymes and TRIM proteins. | 4.25e-09 | 27 | 26 | 4 | 21143188 | |
| Pubmed | Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay. | 4.25e-09 | 27 | 26 | 4 | 30097011 | |
| Pubmed | Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. | 7.41e-09 | 6 | 26 | 3 | 27678051 | |
| Pubmed | 7.41e-09 | 6 | 26 | 3 | 33962630 | ||
| Pubmed | Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. | 7.41e-09 | 6 | 26 | 3 | 15280377 | |
| Pubmed | Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. | 7.41e-09 | 6 | 26 | 3 | 28625874 | |
| Pubmed | Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. | 7.41e-09 | 6 | 26 | 3 | 22124327 | |
| Pubmed | h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. | 7.41e-09 | 6 | 26 | 3 | 16549277 | |
| Pubmed | The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2. | 7.41e-09 | 6 | 26 | 3 | 25701873 | |
| Pubmed | 7.41e-09 | 6 | 26 | 3 | 30404641 | ||
| Pubmed | The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1. | 9.94e-09 | 212 | 26 | 6 | 33853758 | |
| Pubmed | Measuring rates of ubiquitin chain formation as a functional readout of ligase activity. | 1.30e-08 | 7 | 26 | 3 | 22350887 | |
| Pubmed | 1.30e-08 | 7 | 26 | 3 | 34057440 | ||
| Pubmed | Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. | 1.30e-08 | 7 | 26 | 3 | 20347421 | |
| Pubmed | RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. | 1.30e-08 | 7 | 26 | 3 | 20553626 | |
| Pubmed | 1.30e-08 | 7 | 26 | 3 | 20051513 | ||
| Pubmed | 1.30e-08 | 7 | 26 | 3 | 24831002 | ||
| Pubmed | 1.30e-08 | 7 | 26 | 3 | 17719635 | ||
| Pubmed | A ubiquitin ligase complex assembles linear polyubiquitin chains. | 1.30e-08 | 7 | 26 | 3 | 17006537 | |
| Pubmed | The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. | 1.30e-08 | 7 | 26 | 3 | 25278022 | |
| Pubmed | 1.30e-08 | 7 | 26 | 3 | 33282879 | ||
| Pubmed | 2.07e-08 | 8 | 26 | 3 | 25207814 | ||
| Pubmed | Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. | 2.07e-08 | 8 | 26 | 3 | 15247280 | |
| Pubmed | 2.07e-08 | 8 | 26 | 3 | 28972136 | ||
| Pubmed | 2.07e-08 | 8 | 26 | 3 | 18838541 | ||
| Pubmed | A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. | 2.07e-08 | 8 | 26 | 3 | 16682404 | |
| Pubmed | Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. | 2.07e-08 | 8 | 26 | 3 | 14661060 | |
| Pubmed | Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. | 2.07e-08 | 8 | 26 | 3 | 28681414 | |
| Pubmed | 2.07e-08 | 8 | 26 | 3 | 12670957 | ||
| Pubmed | Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. | 3.11e-08 | 9 | 26 | 3 | 12525502 | |
| Pubmed | Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. | 3.11e-08 | 9 | 26 | 3 | 17460044 | |
| Pubmed | Comparison of Cross-Regulation by Different OTUB1:E2 Complexes. | 3.11e-08 | 9 | 26 | 3 | 32049508 | |
| Pubmed | TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. | 3.11e-08 | 9 | 26 | 3 | 17544371 | |
| Pubmed | 3.11e-08 | 9 | 26 | 3 | 26711259 | ||
| Pubmed | E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. | 4.43e-08 | 10 | 26 | 3 | 21518764 | |
| Pubmed | Bag1 directly routes immature BCR-ABL for proteasomal degradation. | 4.43e-08 | 10 | 26 | 3 | 20675402 | |
| Pubmed | 4.43e-08 | 10 | 26 | 3 | 37345264 | ||
| Pubmed | A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing. | 6.09e-08 | 11 | 26 | 3 | 36027913 | |
| Pubmed | 6.09e-08 | 11 | 26 | 3 | 24438103 | ||
| Pubmed | 6.09e-08 | 11 | 26 | 3 | 22334663 | ||
| Pubmed | 6.09e-08 | 11 | 26 | 3 | 19712108 | ||
| Pubmed | E1-E2 interactions in ubiquitin and Nedd8 ligation pathways. | 8.12e-08 | 12 | 26 | 3 | 22069333 | |
| Pubmed | 8.12e-08 | 12 | 26 | 3 | 24905733 | ||
| Pubmed | 1.06e-07 | 13 | 26 | 3 | 31120930 | ||
| Pubmed | 1.06e-07 | 13 | 26 | 3 | 36576150 | ||
| Pubmed | A conserved catalytic residue in the ubiquitin-conjugating enzyme family. | 1.06e-07 | 13 | 26 | 3 | 14517261 | |
| Pubmed | 1.34e-07 | 14 | 26 | 3 | 14690596 | ||
| Pubmed | Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting. | 1.68e-07 | 15 | 26 | 3 | 32265276 | |
| Pubmed | E3-independent monoubiquitination of ubiquitin-binding proteins. | 1.68e-07 | 15 | 26 | 3 | 17588522 | |
| Pubmed | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. | 2.06e-07 | 16 | 26 | 3 | 22496338 | |
| Pubmed | 2.06e-07 | 16 | 26 | 3 | 37225719 | ||
| Pubmed | c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. | 4.89e-07 | 21 | 26 | 3 | 21113135 | |
| Pubmed | 5.37e-07 | 2 | 26 | 2 | 26912277 | ||
| Pubmed | A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. | 5.48e-07 | 88 | 26 | 4 | 27182664 | |
| Pubmed | Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. | 7.46e-07 | 95 | 26 | 4 | 29643511 | |
| Pubmed | Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. | 8.44e-07 | 25 | 26 | 3 | 17597759 | |
| Pubmed | Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase. | 1.61e-06 | 3 | 26 | 2 | 30095198 | |
| Pubmed | DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation. | 1.61e-06 | 3 | 26 | 2 | 34551297 | |
| Pubmed | 1.61e-06 | 3 | 26 | 2 | 11912157 | ||
| Pubmed | 1.61e-06 | 3 | 26 | 2 | 20631078 | ||
| Pubmed | 1.61e-06 | 3 | 26 | 2 | 37226882 | ||
| Pubmed | Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. | 1.61e-06 | 3 | 26 | 2 | 16601690 | |
| Pubmed | Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. | 1.64e-06 | 31 | 26 | 3 | 25527291 | |
| Pubmed | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. | 1.78e-06 | 118 | 26 | 4 | 19690564 | |
| Pubmed | MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. | 1.81e-06 | 32 | 26 | 3 | 20864041 | |
| Pubmed | 3.07e-06 | 38 | 26 | 3 | 35331737 | ||
| Pubmed | 3.22e-06 | 4 | 26 | 2 | 17170710 | ||
| Pubmed | 3.22e-06 | 4 | 26 | 2 | 9535861 | ||
| Pubmed | 3.22e-06 | 4 | 26 | 2 | 20696396 | ||
| Interaction | ARK2C interactions | 7.61e-10 | 12 | 24 | 4 | int:ARK2C | |
| Interaction | RNF150 interactions | 7.40e-09 | 20 | 24 | 4 | int:RNF150 | |
| Interaction | UBOX5 interactions | 1.35e-08 | 23 | 24 | 4 | int:UBOX5 | |
| Interaction | RNF103 interactions | 3.60e-08 | 29 | 24 | 4 | int:RNF103 | |
| Interaction | CADPS2 interactions | 4.15e-08 | 30 | 24 | 4 | int:CADPS2 | |
| Interaction | TRIM62 interactions | 5.44e-08 | 32 | 24 | 4 | int:TRIM62 | |
| Interaction | BIRC8 interactions | 5.44e-08 | 32 | 24 | 4 | int:BIRC8 | |
| Interaction | TRIM45 interactions | 6.18e-08 | 33 | 24 | 4 | int:TRIM45 | |
| Interaction | RNF166 interactions | 6.67e-08 | 91 | 24 | 5 | int:RNF166 | |
| Interaction | TRIM17 interactions | 7.00e-08 | 34 | 24 | 4 | int:TRIM17 | |
| Interaction | DTX1 interactions | 7.90e-08 | 35 | 24 | 4 | int:DTX1 | |
| Interaction | ZNRF1 interactions | 8.88e-08 | 36 | 24 | 4 | int:ZNRF1 | |
| Interaction | UVSSA interactions | 9.95e-08 | 37 | 24 | 4 | int:UVSSA | |
| Interaction | UBTD1 interactions | 1.37e-07 | 40 | 24 | 4 | int:UBTD1 | |
| Interaction | TRIM39 interactions | 1.58e-07 | 108 | 24 | 5 | int:TRIM39 | |
| Interaction | RNF25 interactions | 1.85e-07 | 43 | 24 | 4 | int:RNF25 | |
| Interaction | TRIM38 interactions | 2.67e-07 | 47 | 24 | 4 | int:TRIM38 | |
| Interaction | ZNRF2 interactions | 2.67e-07 | 47 | 24 | 4 | int:ZNRF2 | |
| Interaction | TRIM10 interactions | 2.91e-07 | 48 | 24 | 4 | int:TRIM10 | |
| Interaction | BFAR interactions | 2.91e-07 | 48 | 24 | 4 | int:BFAR | |
| Interaction | TRIM50 interactions | 3.16e-07 | 49 | 24 | 4 | int:TRIM50 | |
| Interaction | RNF14 interactions | 3.16e-07 | 49 | 24 | 4 | int:RNF14 | |
| Interaction | RNF216 interactions | 4.03e-07 | 52 | 24 | 4 | int:RNF216 | |
| Interaction | RNF125 interactions | 4.36e-07 | 53 | 24 | 4 | int:RNF125 | |
| Interaction | TRIM43 interactions | 4.36e-07 | 53 | 24 | 4 | int:TRIM43 | |
| Interaction | TRIM2 interactions | 4.36e-07 | 53 | 24 | 4 | int:TRIM2 | |
| Interaction | RNF115 interactions | 4.63e-07 | 134 | 24 | 5 | int:RNF115 | |
| Interaction | RNF167 interactions | 4.70e-07 | 54 | 24 | 4 | int:RNF167 | |
| Interaction | MYLIP interactions | 5.45e-07 | 56 | 24 | 4 | int:MYLIP | |
| Interaction | RNF26 interactions | 7.21e-07 | 60 | 24 | 4 | int:RNF26 | |
| Interaction | RNF13 interactions | 7.21e-07 | 60 | 24 | 4 | int:RNF13 | |
| Interaction | CHFR interactions | 7.21e-07 | 60 | 24 | 4 | int:CHFR | |
| Interaction | UBE2D3 interactions | 7.91e-07 | 283 | 24 | 6 | int:UBE2D3 | |
| Interaction | RNF122 interactions | 8.23e-07 | 16 | 24 | 3 | int:RNF122 | |
| Interaction | PELI1 interactions | 9.98e-07 | 65 | 24 | 4 | int:PELI1 | |
| Interaction | CNOT4 interactions | 9.98e-07 | 65 | 24 | 4 | int:CNOT4 | |
| Interaction | DTX3L interactions | 1.20e-06 | 68 | 24 | 4 | int:DTX3L | |
| Interaction | RNF11 interactions | 1.46e-06 | 169 | 24 | 5 | int:RNF11 | |
| Interaction | TRIM3 interactions | 2.30e-06 | 80 | 24 | 4 | int:TRIM3 | |
| Interaction | RFWD3 interactions | 2.30e-06 | 80 | 24 | 4 | int:RFWD3 | |
| Interaction | RNF10 interactions | 3.22e-06 | 87 | 24 | 4 | int:RNF10 | |
| Interaction | LRSAM1 interactions | 3.37e-06 | 88 | 24 | 4 | int:LRSAM1 | |
| Interaction | MGRN1 interactions | 3.69e-06 | 90 | 24 | 4 | int:MGRN1 | |
| Interaction | POLM interactions | 3.79e-06 | 26 | 24 | 3 | int:POLM | |
| Interaction | RNF114 interactions | 3.86e-06 | 91 | 24 | 4 | int:RNF114 | |
| Interaction | TRIM5 interactions | 3.86e-06 | 91 | 24 | 4 | int:TRIM5 | |
| Interaction | MKRN3 interactions | 4.24e-06 | 210 | 24 | 5 | int:MKRN3 | |
| Interaction | AREL1 interactions | 4.26e-06 | 27 | 24 | 3 | int:AREL1 | |
| Interaction | TOPORS interactions | 4.78e-06 | 96 | 24 | 4 | int:TOPORS | |
| Interaction | RNF111 interactions | 4.98e-06 | 97 | 24 | 4 | int:RNF111 | |
| Interaction | RNF168 interactions | 5.18e-06 | 98 | 24 | 4 | int:RNF168 | |
| Interaction | TRIM8 interactions | 5.62e-06 | 100 | 24 | 4 | int:TRIM8 | |
| Interaction | MUL1 interactions | 5.85e-06 | 101 | 24 | 4 | int:MUL1 | |
| Interaction | RNF38 interactions | 6.08e-06 | 102 | 24 | 4 | int:RNF38 | |
| Interaction | TRIM35 interactions | 6.32e-06 | 103 | 24 | 4 | int:TRIM35 | |
| Interaction | DTX3 interactions | 7.63e-06 | 108 | 24 | 4 | int:DTX3 | |
| Interaction | UBE4A interactions | 7.91e-06 | 109 | 24 | 4 | int:UBE4A | |
| Interaction | ZNRF4 interactions | 8.21e-06 | 110 | 24 | 4 | int:ZNRF4 | |
| Interaction | UFM1 interactions | 1.05e-05 | 117 | 24 | 4 | int:UFM1 | |
| Interaction | MID1 interactions | 1.12e-05 | 119 | 24 | 4 | int:MID1 | |
| Interaction | HECW1 interactions | 1.12e-05 | 37 | 24 | 3 | int:HECW1 | |
| Interaction | HECTD1 interactions | 1.15e-05 | 984 | 24 | 8 | int:HECTD1 | |
| Interaction | MID2 interactions | 1.36e-05 | 267 | 24 | 5 | int:MID2 | |
| Interaction | RNF5 interactions | 1.40e-05 | 126 | 24 | 4 | int:RNF5 | |
| Interaction | MARCHF3 interactions | 1.77e-05 | 43 | 24 | 3 | int:MARCHF3 | |
| Interaction | RNF126 interactions | 2.01e-05 | 138 | 24 | 4 | int:RNF126 | |
| Interaction | UBE2D1 interactions | 2.16e-05 | 294 | 24 | 5 | int:UBE2D1 | |
| Interaction | MIB1 interactions | 2.20e-05 | 295 | 24 | 5 | int:MIB1 | |
| Interaction | HERC1 interactions | 2.38e-05 | 144 | 24 | 4 | int:HERC1 | |
| Interaction | TRIM27 interactions | 2.43e-05 | 514 | 24 | 6 | int:TRIM27 | |
| Interaction | RMND5B interactions | 2.64e-05 | 49 | 24 | 3 | int:RMND5B | |
| Interaction | RNF7 interactions | 2.79e-05 | 150 | 24 | 4 | int:RNF7 | |
| Interaction | PJA2 interactions | 3.09e-05 | 154 | 24 | 4 | int:PJA2 | |
| Interaction | UBE2D2 interactions | 3.15e-05 | 318 | 24 | 5 | int:UBE2D2 | |
| Interaction | TRIM54 interactions | 3.29e-05 | 321 | 24 | 5 | int:TRIM54 | |
| Interaction | BARD1 interactions | 3.39e-05 | 323 | 24 | 5 | int:BARD1 | |
| Interaction | RNF185 interactions | 3.42e-05 | 158 | 24 | 4 | int:RNF185 | |
| Interaction | RNF181 interactions | 3.59e-05 | 160 | 24 | 4 | int:RNF181 | |
| Interaction | MAP3K1 interactions | 3.68e-05 | 161 | 24 | 4 | int:MAP3K1 | |
| Interaction | RNF34 interactions | 3.95e-05 | 56 | 24 | 3 | int:RNF34 | |
| Interaction | BIRC7 interactions | 4.16e-05 | 57 | 24 | 3 | int:BIRC7 | |
| Interaction | TRIM11 interactions | 4.87e-05 | 173 | 24 | 4 | int:TRIM11 | |
| Interaction | RBCK1 interactions | 5.21e-05 | 176 | 24 | 4 | int:RBCK1 | |
| Interaction | DZIP3 interactions | 6.06e-05 | 183 | 24 | 4 | int:DZIP3 | |
| Interaction | UBA1 interactions | 7.34e-05 | 380 | 24 | 5 | int:UBA1 | |
| Interaction | MKRN2 interactions | 7.81e-05 | 385 | 24 | 5 | int:MKRN2 | |
| Interaction | UHRF2 interactions | 8.56e-05 | 200 | 24 | 4 | int:UHRF2 | |
| Interaction | RING1 interactions | 8.73e-05 | 201 | 24 | 4 | int:RING1 | |
| Interaction | UBE3C interactions | 9.24e-05 | 204 | 24 | 4 | int:UBE3C | |
| Interaction | CBLC interactions | 9.47e-05 | 75 | 24 | 3 | int:CBLC | |
| Interaction | POLL interactions | 9.85e-05 | 76 | 24 | 3 | int:POLL | |
| Interaction | RNF146 interactions | 1.02e-04 | 77 | 24 | 3 | int:RNF146 | |
| Interaction | TRAIP interactions | 1.02e-04 | 77 | 24 | 3 | int:TRAIP | |
| Interaction | F12 interactions | 1.02e-04 | 77 | 24 | 3 | int:F12 | |
| Interaction | MARCHF7 interactions | 1.06e-04 | 78 | 24 | 3 | int:MARCHF7 | |
| Interaction | ANAPC11 interactions | 1.06e-04 | 78 | 24 | 3 | int:ANAPC11 | |
| Interaction | HLA-E interactions | 1.11e-04 | 79 | 24 | 3 | int:HLA-E | |
| Interaction | TRIM7 interactions | 1.19e-04 | 81 | 24 | 3 | int:TRIM7 | |
| Interaction | EPS15 interactions | 1.24e-04 | 220 | 24 | 4 | int:EPS15 | |
| Interaction | RNF19B interactions | 1.28e-04 | 83 | 24 | 3 | int:RNF19B | |
| Cytoband | 7p13 | 2.26e-04 | 39 | 26 | 2 | 7p13 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr7p13 | 4.18e-04 | 53 | 26 | 2 | chr7p13 | |
| GeneFamily | Ubiquitin conjugating enzymes E2 | 8.61e-08 | 41 | 19 | 4 | 102 | |
| GeneFamily | G-patch domain containing|Minor histocompatibility antigens | 2.39e-04 | 22 | 19 | 2 | 579 | |
| CoexpressionAtlas | facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4 | 6.01e-05 | 1370 | 23 | 8 | facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4 | |
| Computational | Genes in the cancer module 233. | 1.77e-08 | 22 | 15 | 4 | MODULE_233 | |
| Computational | Genes in the cancer module 82. | 2.57e-08 | 24 | 15 | 4 | MODULE_82 | |
| Computational | Ubiquitin ligases. | 1.11e-07 | 34 | 15 | 4 | MODULE_278 | |
| Computational | Genes in the cancer module 4. | 2.88e-06 | 21 | 15 | 3 | MODULE_4 | |
| Computational | Proteasome. | 1.18e-03 | 37 | 15 | 2 | MODULE_91 | |
| Disease | Headache, fasting blood glucose measurement | 1.33e-05 | 7 | 24 | 2 | EFO_0004465, HP_0002315 | |
| Disease | cutaneous melanoma, hair color | 1.16e-03 | 62 | 24 | 2 | EFO_0000389, EFO_0003924 | |
| Disease | neuroimaging measurement | 1.48e-03 | 1069 | 24 | 5 | EFO_0004346 | |
| Disease | nevus count, cutaneous melanoma | 2.48e-03 | 91 | 24 | 2 | EFO_0000389, EFO_0004632 | |
| Disease | cutaneous melanoma | 4.34e-03 | 121 | 24 | 2 | EFO_0000389 | |
| Disease | serum alanine aminotransferase measurement | 4.96e-03 | 869 | 24 | 4 | EFO_0004735 | |
| Disease | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 5.06e-03 | 131 | 24 | 2 | C4704862 | |
| Disease | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 5.06e-03 | 131 | 24 | 2 | C4552091 | |
| Disease | Juvenile arthritis | 5.06e-03 | 131 | 24 | 2 | C3495559 | |
| Disease | Juvenile psoriatic arthritis | 5.06e-03 | 131 | 24 | 2 | C3714758 | |
| Disease | Juvenile-Onset Still Disease | 5.37e-03 | 135 | 24 | 2 | C0087031 | |
| Disease | Parkinson's disease (implicated_via_orthology) | 7.19e-03 | 157 | 24 | 2 | DOID:14330 (implicated_via_orthology) | |
| Disease | parental longevity | 7.27e-03 | 494 | 24 | 3 | EFO_0007796 | |
| Disease | hemoglobin A1 measurement | 8.36e-03 | 520 | 24 | 3 | EFO_0007629 | |
| Disease | mean corpuscular hemoglobin concentration | 1.14e-02 | 1105 | 24 | 4 | EFO_0004528 | |
| Disease | Alzheimer disease, polygenic risk score | 1.16e-02 | 586 | 24 | 3 | EFO_0030082, MONDO_0004975 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| LFSFPFLCHPLPLPS | 26 | Q9N2K0 | |
| LCFPYYPSPGVLFPK | 411 | Q5SSJ5 | |
| CLAFFPPTPKFHSYL | 811 | Q9C0H5 | |
| PPGYHPFLFLDSLHK | 376 | Q5T089 | |
| DTHFYPPFFLLLGIP | 6 | Q8NGH9 | |
| GPFCPTLRLLHKYPF | 76 | A0A3B3IRV3 | |
| PPDHFLPESYTCFFL | 4751 | O95714 | |
| HYFLFGFLAPKKFPC | 161 | Q96KN9 | |
| PFYKTDPFIFPECPH | 386 | P49005 | |
| YIPPAHCKVKPNFPF | 396 | Q9UKJ3 | |
| PGHAVPPAVKYFFDF | 1646 | O15031 | |
| PYFCLPTFGFKHILP | 201 | P18564 | |
| PPPTHLFYLHCVLSF | 361 | Q2VPB7 | |
| YPLHTFFIPFLPSGF | 26 | Q9GZL8 | |
| LHPSTTPYPGGFKCF | 36 | Q86Y78 | |
| PFCHKPCYATLFGPK | 51 | P52943 | |
| GFRIYHKLDPPPFSL | 6 | O43426 | |
| FLTIHFPTDYPFKPP | 51 | P62837 | |
| IHGAVFPFVFYPVKP | 2656 | Q96RL7 | |
| CHFPGFPVLQSFLPK | 1751 | Q8IZQ1 | |
| FLTIHFPTDYPFKPP | 51 | P61077 | |
| LHPGDLYPFTRKPLF | 416 | Q8N9R8 | |
| PYPGLCPLTFHPSFF | 131 | Q86TA4 | |
| FLTIHFPTDYPFKPP | 51 | Q9Y2X8 | |
| CPFRPYHSPLLVFKS | 1141 | O60293 | |
| YPTHKSLKPCPFFLE | 171 | Q8N5A5 | |
| PPLLGFKELYPAFCI | 1021 | Q15386 | |
| FLTVHFPTDYPFKPP | 51 | P51668 |