Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNotch binding

JAG2 JAG1 DLK2

9.11e-0527653GO:0005112
GeneOntologyMolecularFunctionlaminin binding

THBS1 PXDN ITGA6

1.83e-0434653GO:0043236
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

MTMR6 MTMR4

5.63e-0411652GO:0052629
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

BRPF1 BRD1

5.63e-0411652GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

BRPF1 BRD1

5.63e-0411652GO:0043995
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

BRPF1 BRD1

6.74e-0412652GO:0043997
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate phosphatase activity

MTMR6 MTMR4

9.26e-0414652GO:0004438
GeneOntologyMolecularFunctionphosphatidylinositol monophosphate phosphatase activity

MTMR6 MTMR4

1.07e-0315652GO:0052744
GeneOntologyMolecularFunctionneurotrophin receptor binding

NTF3 PLCG1

1.07e-0315652GO:0005165
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR6 MTMR4

1.22e-0316652GO:0106018
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

THBS1 LDLR

1.54e-0318652GO:0030169
GeneOntologyMolecularFunctiongrowth factor binding

THBS1 PXDN NTF3 ITGA6

1.68e-03156654GO:0019838
GeneOntologyMolecularFunctionextracellular matrix binding

THBS1 PXDN ITGA6

1.74e-0373653GO:0050840
GeneOntologyMolecularFunctionRNA helicase activity

DDX31 TDRD9 DDX3Y

2.10e-0378653GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DDX31 TDRD9 DDX3Y

2.26e-0380653GO:0008186
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF1 BRD1

1.98e-047652GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF1 BRD1

2.63e-048652GO:0070775
DomainEGF_CA

JAG2 THBS1 JAG1 NCAN DLK2 TENM2 LDLR

2.17e-07122657SM00179
DomainEGF-like_Ca-bd_dom

JAG2 THBS1 JAG1 NCAN DLK2 TENM2 LDLR

2.43e-07124657IPR001881
DomainEGF_3

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

1.52e-06235658PS50026
DomainEGF

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

1.52e-06235658SM00181
DomainEGF-like_dom

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

2.34e-06249658IPR000742
DomainEGF_1

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

2.79e-06255658PS00022
DomainEGF-like_CS

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

3.31e-06261658IPR013032
DomainEGF_2

JAG2 THBS1 ADAM23 JAG1 NCAN DLK2 TENM2 LDLR

3.71e-06265658PS01186
DomainVWC

JAG2 THBS1 PXDN JAG1

9.02e-0638654SM00214
DomainJagged/Serrate

JAG2 JAG1

1.19e-052652IPR026219
DomainVWF_dom

JAG2 THBS1 PXDN JAG1

1.35e-0542654IPR001007
DomainEGF_Ca-bd_CS

JAG2 JAG1 NCAN DLK2 LDLR

2.20e-0597655IPR018097
DomainEGF_CA

JAG2 JAG1 NCAN DLK2 LDLR

2.43e-0599655PS01187
DomainASX_HYDROXYL

JAG2 JAG1 NCAN DLK2 LDLR

2.55e-05100655PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 JAG1 NCAN DLK2 LDLR

3.37e-05106655IPR000152
DomainEGF_extracell

JAG2 ADAM23 JAG1 DLK2

5.63e-0560654IPR013111
DomainEGF_2

JAG2 ADAM23 JAG1 DLK2

5.63e-0560654PF07974
DomainDSL

JAG2 JAG1

7.12e-054652PF01414
DomainDSL

JAG2 JAG1

7.12e-054652SM00051
DomainBromodomain_CS

BRPF1 BRD1 BRWD1

9.88e-0526653IPR018359
DomainDSL

JAG2 JAG1

1.18e-045652IPR001774
DomainDSL

JAG2 JAG1

1.18e-045652PS51051
DomainNotch_ligand_N

JAG2 JAG1

1.18e-045652IPR011651
DomainMNNL

JAG2 JAG1

1.18e-045652PF07657
DomainhEGF

JAG2 JAG1 DLK2

1.24e-0428653PF12661
DomainKringle-like

MRC1 PRSS12 LY75

1.86e-0432653IPR013806
DomainEGF_CA

JAG2 THBS1 JAG1 LDLR

2.29e-0486654PF07645
DomainVWFC_1

JAG2 THBS1 PXDN

2.65e-0436653PS01208
DomainWD40_repeat_CS

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.65e-04164655IPR019775
DomainBROMODOMAIN_1

BRPF1 BRD1 BRWD1

2.87e-0437653PS00633
DomainBromodomain

BRPF1 BRD1 BRWD1

3.11e-0438653PF00439
DomainVWFC_2

JAG2 THBS1 PXDN

3.11e-0438653PS50184
DomainEPL1

BRPF1 BRD1

3.29e-048652PF10513
DomainEnhancer_polycomb-like_N

BRPF1 BRD1

3.29e-048652IPR019542
DomainBROMODOMAIN_2

BRPF1 BRD1 BRWD1

3.90e-0441653PS50014
DomainBROMO

BRPF1 BRD1 BRWD1

4.19e-0442653SM00297
DomainBromodomain

BRPF1 BRD1 BRWD1

4.19e-0442653IPR001487
Domain-

BRPF1 BRD1 BRWD1

4.19e-04426531.20.920.10
DomainC-type_lectin_CS

MRC1 NCAN LY75

4.49e-0443653IPR018378
DomainWD40_repeat_dom

FBXW10B FBXW10 STRAP ARHGEF10 CDC20B BRWD1

5.78e-04297656IPR017986
DomainEGF

JAG2 JAG1 NCAN DLK2

9.73e-04126654PF00008
Domain-

FBXW10B FBXW10 STRAP ARHGEF10 CDC20B BRWD1

1.05e-033336562.130.10.10
DomainFN_type2_col-bd

MRC1 LY75

1.06e-0314652IPR000562
DomainFN2_2

MRC1 LY75

1.06e-0314652PS51092
DomainMyotubularin-like_Pase_dom

MTMR6 MTMR4

1.06e-0314652IPR010569
DomainPPASE_MYOTUBULARIN

MTMR6 MTMR4

1.06e-0314652PS51339
DomainMyotubularin_fam

MTMR6 MTMR4

1.06e-0314652IPR030564
DomainMyotub-related

MTMR6 MTMR4

1.06e-0314652PF06602
Domainfn2

MRC1 LY75

1.06e-0314652PF00040
DomainFN2_1

MRC1 LY75

1.06e-0314652PS00023
DomainFN2

MRC1 LY75

1.06e-0314652SM00059
DomainWD40/YVTN_repeat-like_dom

FBXW10B FBXW10 STRAP ARHGEF10 CDC20B BRWD1

1.08e-03335656IPR015943
DomainVWC_out

JAG2 JAG1

1.96e-0319652SM00215
DomainWD40

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.07e-03259655PF00400
DomainDEAD/DEAH_box_helicase_dom

DDX31 TDRD9 DDX3Y

2.10e-0373653IPR011545
DomainDEAD

DDX31 TDRD9 DDX3Y

2.10e-0373653PF00270
DomainPWWP

BRPF1 BRD1

2.18e-0320652SM00293
DomainWD40

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.40e-03268655SM00320
DomainWD40_repeat

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.56e-03272655IPR001680
DomainEPHD

BRPF1 BRD1

2.63e-0322652PS51805
DomainC_TYPE_LECTIN_1

MRC1 NCAN LY75

2.73e-0380653PS00615
DomainWD_REPEATS_1

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.81e-03278655PS00678
DomainWD_REPEATS_2

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.85e-03279655PS50082
DomainWD_REPEATS_REGION

FBXW10B FBXW10 STRAP CDC20B BRWD1

2.85e-03279655PS50294
DomainPWWP

BRPF1 BRD1

2.88e-0323652PF00855
DomainTSPN

COL24A1 THBS1

2.88e-0323652SM00210
DomainPWWP_dom

BRPF1 BRD1

2.88e-0323652IPR000313
DomainPWWP

BRPF1 BRD1

3.13e-0324652PS50812
DomainLectin_C

MRC1 NCAN LY75

3.14e-0384653PF00059
DomainCLECT

MRC1 NCAN LY75

3.14e-0384653SM00034
DomainG-protein_beta_WD-40_rep

FBXW10B FBXW10 STRAP

3.24e-0385653IPR020472
DomainC_TYPE_LECTIN_2

MRC1 NCAN LY75

3.24e-0385653PS50041
DomainC-type_lectin-like

MRC1 NCAN LY75

3.35e-0386653IPR001304
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

THBS1 DDX31 PXDN ARHGEF10 BRPF1 LARS2 LDLR

2.94e-0633265737433992
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

JAG2 ATMIN PRUNE2 PXDN ZNF33A NTF3 RBM4 AKAP13 CACNA1H ANKMY1 PPIE PLCG1 CRAMP1

3.17e-061489651328611215
Pubmed

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.

JAG2 JAG1

3.44e-06265224708907
Pubmed

Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.

BRPF1 BRD1

3.44e-06265224333487
Pubmed

Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool.

JAG2 JAG1

3.44e-06265238750026
Pubmed

FBXW10 promotes hepatocarcinogenesis in male patients and mice.

FBXW10B FBXW10

3.44e-06265231400758
Pubmed

Soluble form of Jagged1: unique product of epithelial keratinocytes and a regulator of keratinocyte differentiation.

THBS1 JAG1

3.44e-06265215258909
Pubmed

Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

FBXW10B FBXW10

3.44e-06265237450367
Pubmed

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.

JAG2 JAG1

3.44e-06265228111308
Pubmed

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction.

JAG2 JAG1

3.44e-06265211549580
Pubmed

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.

JAG2 PPY JAG1

6.94e-062065319501159
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

JAG2 PPY JAG1

8.09e-062165314702043
Pubmed

Notch signaling drives multiple myeloma induced osteoclastogenesis.

JAG2 JAG1

1.03e-05365225257302
Pubmed

BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.

PRUNE2 AKAP13

1.03e-05365218445682
Pubmed

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

BRPF1 BRD1

1.03e-05365220400950
Pubmed

Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.

JAG2 JAG1

1.03e-05365224191040
Pubmed

Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.

JAG2 JAG1

1.03e-0536529716576
Pubmed

β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.

JAG2 JAG1

1.03e-05365224907271
Pubmed

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

JAG2 JAG1

1.03e-05365223530123
Pubmed

Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice.

JAG2 JAG1

1.03e-05365211841846
Pubmed

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.

JAG1 ITGA6

2.06e-05465220940224
Pubmed

Thrombospondin 2 potentiates notch3/jagged1 signaling.

THBS1 JAG1

2.06e-05465219147503
Pubmed

A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea.

JAG2 JAG1

2.06e-05465210837254
Pubmed

Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.

JAG2 JAG1

2.06e-05465220602435
Pubmed

Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.

BRPF1 BRD1

2.06e-05465224258712
Pubmed

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

JAG2 JAG1

2.06e-0546529315665
Pubmed

Activation of Notch signaling in human tongue carcinoma.

JAG2 JAG1

2.06e-05465220819128
Pubmed

Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.

PLCG1 LDLR

2.06e-05465217962812
Pubmed

Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.

JAG2 JAG1

2.06e-05465237966490
Pubmed

Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin.

THBS1 ITGA6

2.06e-05465212909644
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

JAG2 JAG1

2.06e-05465220040020
Pubmed

Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.

MTHFD1 LY75

2.06e-05465219706888
Pubmed

CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics.

MRC1 LY75

2.06e-05465223603511
Pubmed

The Notch signalling pathway in hair growth.

JAG2 JAG1

2.06e-0546529858728
Pubmed

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.

BRPF1 BRD1

2.06e-05465226677226
Pubmed

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

JAG2 JAG1

2.06e-05465224398584
Pubmed

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

BRPF1 BRD1

2.06e-05465224065767
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

JAG2 JAG1 DLK2

2.20e-052965321402740
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MTMR6 MTHFD1 TTLL4 GRAMD2B DDX3Y AATF PLCG1 TASOR LDLR BRWD1

3.14e-051084651011544199
Pubmed

3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.

JAG2 JAG1

3.43e-05565230244870
Pubmed

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

JAG2 JAG1

3.43e-05565211006133
Pubmed

FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.

FBXW10B FBXW10

3.43e-05565237277019
Pubmed

Functional diversity of notch family genes in fetal lung development.

JAG2 JAG1

3.43e-05565215064243
Pubmed

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.

JAG2 JAG1

3.43e-05565221602525
Pubmed

The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface.

JAG2 JAG1

3.43e-05565215788413
Pubmed

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain.

JAG2 JAG1

3.43e-05565212175503
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAG2 ATMIN ARVCF TTLL4 AKAP13 CACNA1H PLCG1 LARS2 LDLR CRAMP1

3.69e-051105651035748872
Pubmed

Identification of the BRD1 interaction network and its impact on mental disorder risk.

KMT5B LYAR BRD1

3.91e-053565327142060
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

JAG2 JAG1

5.13e-05665210958687
Pubmed

High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays.

THBS1 JAG1

5.13e-05665218254948
Pubmed

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.

NCAN LDLR

5.13e-05665210811610
Pubmed

NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.

NTF3 AATF

5.13e-05665217488777
Pubmed

Structural and histone binding ability characterizations of human PWWP domains.

BRPF1 BRD1

5.13e-05665221720545
Pubmed

A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.

MRC1 JAG1 BRD1 PEX5L TASOR

5.62e-0521865519460752
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

FBXW10B MTMR6 FBXW10 MTMR4 LATS1 SULT2B1 MTHFD1 LDLR

6.38e-0573065834857952
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

MTMR6 MTMR4 STRAP ARHGEF10 RBM4 TTLL4 AKAP13 TASOR

6.56e-0573365834672954
Pubmed

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

JAG2 JAG1

7.18e-05765210383933
Pubmed

Human ligands of the Notch receptor.

JAG2 JAG1

7.18e-05765210079256
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

BRPF1 BRD1

7.18e-05765218794358
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 JAG1

7.18e-05765212846471
Pubmed

Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.

THBS1 JAG1

7.18e-0576529889000
Pubmed

Evidence for a Notch1-mediated transition during olfactory ensheathing cell development.

JAG2 JAG1

7.18e-05765227271278
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

STRAP MTHFD1 PLCG1 SRBD1 LARS2

8.34e-0523765529564676
Pubmed

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

JAG2 JAG1

9.56e-05865217626181
Pubmed

P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.

JAG2 JAG1

9.56e-05865222652674
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 JAG1

9.56e-0586529858718
Pubmed

Notch/Delta expression in the developing mouse lung.

JAG2 JAG1

9.56e-05865211044610
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 JAG1

1.23e-04965211118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 JAG1

1.23e-04965216245338
Pubmed

Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.

JAG2 JAG1

1.23e-04965211944948
Pubmed

Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.

MRC1 JAG1

1.23e-04965230758286
Pubmed

Notch signaling is essential for vascular morphogenesis in mice.

JAG2 JAG1

1.23e-04965210837027
Pubmed

Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress.

JAG2 JAG1

1.53e-041065226542370
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 JAG1

1.53e-041065223665443
Pubmed

Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.

MTMR6 MTMR4

1.53e-04106529736772
Pubmed

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.

THBS1 ITGA6 LDLR

1.61e-045665337059927
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 JAG1

1.87e-041165210878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 JAG1

1.87e-041165212866128
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

JAG2 THBS1 JAG1

1.88e-045965321421844
Pubmed

Dll3 is expressed in developing hair cells in the mammalian cochlea.

JAG2 JAG1

2.24e-041265217823936
Pubmed

p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.

JAG2 JAG1

2.24e-041265226527653
Pubmed

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.

MTMR6 MTMR4

2.24e-041265216787938
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 JAG1

2.24e-041265215465494
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

JAG2 JAG1

2.65e-041365231202705
Pubmed

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

JAG2 JAG1

2.65e-041365211171333
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 JAG1

2.65e-041365211578869
Pubmed

Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage.

JAG2 JAG1

2.65e-041365211934853
Pubmed

The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.

JAG2 JAG1

2.65e-041365234838591
Pubmed

Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.

THBS1 LDLR

2.65e-041365214557872
Pubmed

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

JAG2 JAG1

3.08e-041465218528438
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

JAG2 JAG1

3.08e-041465228192800
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 JAG1

3.08e-041465214757642
Pubmed

Notch1 is required for neuronal and glial differentiation in the cerebellum.

JAG2 JAG1

3.08e-041465211807030
Pubmed

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.

JAG2 JAG1

3.08e-041465225564622
Pubmed

BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

JAG2 JAG1

3.56e-041565216324690
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 JAG1

3.56e-041565212971992
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

JAG2 JAG1

3.56e-041565212167404
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

JAG2 JAG1

3.56e-041565216914494
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

JAG2 THBS1 PXDN STRAP RBM4 IFI30 ITGA6 RXYLT1 LDLR

3.81e-04120165935696571
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

BRPF1 BRD1 BRWD1

3.82e-047565325593309
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

MTHFD1 DDX3Y AKAP13 LY75

1.38e-0551524870
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10B FBXW10

4.39e-0411522559
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR6 MTMR4

8.32e-0415522903
GeneFamilyWD repeat domain containing

FBXW10B FBXW10 STRAP CDC20B BRWD1

9.17e-04262525362
GeneFamilyPWWP domain containing

BRPF1 BRD1

1.81e-03225221147
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

MRC1 LY75

2.72e-03275221253
GeneFamilyPhosphoinositide phosphatases

MTMR6 MTMR4

3.81e-03325221079
GeneFamilyDEAD-box helicases

DDX31 DDX3Y

6.49e-0342522499
GeneFamilyC-type lectin domain family

MRC1 LY75

8.07e-0347522494
ToppCell3'_v3|World / Manually curated celltypes from each tissue

MRC1 THBS1 RBM4 AKAP13 LYAR BRD1

2.40e-0717865642502f14d9c756df8104900ac6484477b885d3d9
ToppCellfacs-Skin-Anagen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 MTHFD1 DLK2 ITGA6 DDX3Y LARS2

3.74e-07192656ec1fd2fb6e71f87189d66261909a84e2be63cacb
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULT2B1 PRSS12 NTF3 JAG1 GRAMD2B

3.49e-06158655d78e7e52657dc094430291fec07e9c298be9e584
ToppCellPND07-28-samps-Myeloid-Macrophage|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PRUNE2 MRC1 IFI30 LY75 LARS2

3.95e-061626557c73fe8388af370461e04097cf145cbc9847285b
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PPY NTF3 BRPF1 JAG1

4.58e-06167655a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PPY AKAP13 LARS2 TASOR

5.44e-06173655869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PPY AKAP13 LARS2 TASOR

5.44e-061736550672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PPY AKAP13 LARS2 TASOR

5.44e-06173655870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellfacs-Skin-nan-24m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THBS1 NTF3 DLK2 SDCBP2

5.75e-0617565521542be95059983d2c8bdf01ec711fdbf1ec1f62
ToppCellfacs|World / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG1 ITGA6 PLCG1 LARS2 TENM2

6.42e-061796558001db3044e8657980e24422377c4fdb0d7b323e
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THBS1 DLK2 ITGA6 LDLR

7.93e-061876559c1013720c248ef201d010806b6e7ad24205e8ee
ToppCelldroplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THBS1 NTF3 DLK2 ITGA6

8.57e-06190655c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCellfacs-Liver-Non-hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PXDN PPY ADAM23 LARS2

9.24e-061936558084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 SULT2B1 NTF3 DLK2 TENM2

1.07e-05199655995d710d7302272e7951a5a5d766d1039089ee2b
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 SULT2B1 NTF3 DLK2 TENM2

1.07e-05199655e9c47f565a0a7737ecff68569d668aeb707ae5a6
ToppCell(02)_MMP9/10+|World / shred by cell type by condition

THBS1 PXDN JAG1 ITGA6 TENM2

1.07e-051996553f78eddeaa67d3b767aa38de765632166b09a4f0
ToppCellmetastatic_Brain-T/NK_cells-CD8_low_T|T/NK_cells / Location, Cell class and cell subclass

COL24A1 ZNF486 LYAR UNC79

4.96e-05138654b2ab273f3e62f169b3b9cb82342e6617af99f582
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRSS12 GRAMD2B LYAR LARS2

6.18e-05146654deeb2c90a478deac7805e1f0d1466bf5bc42f746
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXW10 ZNF732 CDC20B DLK2

6.68e-05149654a6406c4c9404271a2f4c615c6cd3265b2d759b12
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF486 RBM4 FAM200A LYAR

6.68e-051496542a7f71da51c85e04de2123164914122480e60d66
ToppCellBasal_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

ZNF486 NTF3 DLK2 TENM2

7.22e-0515265472499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SULT2B1 PRSS12 GRAMD2B CDC20B

7.41e-05153654edf5d026e8e4c685b7c369d70894741bb2cd568e
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SULT2B1 PRSS12 GRAMD2B CDC20B

7.41e-051536543240d4d690335ba22317b1f3d33f9ea069e93838
ToppCelldroplet-Marrow-BM-30m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPY IFI30 DDX3Y AKAP13

8.81e-05160654822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SULT2B1 PRSS12 DLK2 TENM2

9.02e-05161654ba7ce599b173cf81c8323e7c96dc3d57379f1ed6
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PRUNE2 MRC1 IFI30 LY75

9.02e-051616545925ee646aa040550e3f8a164a13c8a5c0353319
ToppCellfacs-Heart-LV-24m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 MRC1 IFI30 TENM2

9.24e-051626545dfdb4e227e5d7d72dbe8fe032791fddb0be064d
ToppCellfacs-Heart-LV-24m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 MRC1 IFI30 TENM2

9.24e-051626547f26135b884144473bbccaf3881c8cf2ba4fa05a
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PXDN ZNF266 ARVCF ARHGEF10

9.46e-051636546c4d4c55fc8a731acca13c1ba7287f238a9d81e0
ToppCellPND01-03-samps-Myeloid-Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PRUNE2 MRC1 IFI30 LY75

9.69e-0516465449733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell390C-Lymphocytic-ILC-ILC-2|390C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 COL24A1 PLCG1 LDLR

1.06e-041686542781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCelldroplet-Marrow-BM-30m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPY NCAN DDX3Y CACNA1H

1.09e-041696548e7a30eb546fc6fa184ebb76f54b74b278005a84
ToppCellClub_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

PXDN SULT2B1 NTF3 GRAMD2B

1.09e-0416965403b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

JAG2 NTF3 DLK2 ITGA6

1.11e-041706540cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

JAG2 NTF3 DLK2 ITGA6

1.11e-041706542d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBXW10B PRSS12 ITGA6 TENM2

1.14e-04171654121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCellAdult-Epithelial-basal_cell-D231|Adult / Lineage, Cell type, age group and donor

JAG2 NTF3 GRAMD2B DLK2

1.22e-04174654a4f98afe7d1cc2617f6f7bc8092c41df57474b30
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPY AKAP13 LARS2 TASOR

1.24e-041756541ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 MRC1 RBM4 LY75

1.27e-04176654450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM23 PRSS12 GPAM PEX5L

1.30e-0417765459cf56c385c324f0844f20003d2b5049a2791e45
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 PPY NCAN DDX3Y

1.30e-041776541dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCellfacs-Lung-EPCAM-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 ADAM23 GRAMD2B LY75

1.30e-04177654d445167dae956e641386f84ab3ae9f47c089e09a
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 PPY NCAN DDX3Y

1.30e-04177654426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCellCOPD-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

JAG2 NTF3 JAG1 DLK2

1.33e-04178654441d1dba720141891b11f404744c59834d80e6c5
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULT2B1 PRSS12 NTF3 GRAMD2B

1.33e-04178654fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_proximal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SULT2B1 NTF3 GRAMD2B DLK2

1.33e-041786549534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCellfacs-Lung-EPCAM-24m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 ADAM23 IFI30 LY75

1.36e-0417965451872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 ADAM23 IFI30 LY75

1.36e-041796541b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCellCOVID-19-Heart-VSMC|Heart / Disease (COVID-19 only), tissue and cell type

PRUNE2 NTF3 JAG1 CACNA1H

1.36e-04179654a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCellwk_15-18-Epithelial-Proximal_epithelial-basal_late|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

JAG2 SULT2B1 GRAMD2B DLK2

1.39e-04180654255097d8eb244a32eb2ecd0e7e48e1a20bafb5cd
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 DDX31 LY75 CRAMP1

1.45e-0418265457f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCellAdult-Epithelial-basal_cell|Adult / Lineage, Cell type, age group and donor

JAG2 NTF3 GRAMD2B DLK2

1.48e-0418365400a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCellBasal|World / shred by cell class for mouse tongue

JAG2 MTHFD1 DLK2 ITGA6

1.48e-04183654c6729a207526ff4aa48176207b9353176f631fea
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

THBS1 TDRD9 ADAM23 TENM2

1.48e-041836542902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBXW10 ADAM23 PRSS12 BRPF1

1.48e-04183654dc9602bed3136db91faeffef177006246dc92743
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 SULT2B1 CACNA1H PEX5L

1.51e-041846543e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SULT2B1 PRSS12 DLK2 TENM2

1.51e-0418465425ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 SULT2B1 CACNA1H PEX5L

1.51e-041846541e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 NTF3 JAG1 ITGA6

1.54e-04185654efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 NTF3 JAG1 ITGA6

1.54e-04185654642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR6 KMT5B DDX3Y LARS2

1.54e-04185654a2cae8c657e4f4d121476798e424876f7e247973
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MTMR4 ADAM23 IFI30 LY75

1.54e-0418565419fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR6 KMT5B DDX3Y LARS2

1.54e-04185654d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|metastatic_Brain / Location, Cell class and cell subclass

MRC1 THBS1 IFI30 LYAR

1.57e-041866549270e04c61b743874424a5935537b62e7d89c461
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

PRUNE2 THBS1 JAG1 CACNA1H

1.60e-04187654464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SULT2B1 GRAMD2B CDC20B DLK2

1.60e-04187654f6ea69360dca9839ddaaaaca26a7dbb570d23262
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PRUNE2 JAG1 SDCBP2

1.64e-04188654ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 AKAP13 TENM2 LDLR

1.64e-04188654a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 THBS1 CACNA1H LDLR

1.67e-041896542aebea7a6c2f83112d7c504b742f2c04b92e459a
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 THBS1 PPY IFI30

1.67e-04189654e4b2f00cb3675a4d94e8807d6ff99cc55f9ed233
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 NTF3 DLK2 LDLR

1.67e-041896541cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

ADAM23 JAG1 DLK2 ITGA6

1.67e-04189654aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCelldroplet-Bladder-nan-24m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG1 DDX3Y SDCBP2 LDLR

1.71e-04190654725657faf90b8ef0a286a3fd64ed18ab600aa2df
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

THBS1 TDRD9 TENM2 LDLR

1.71e-041906543729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NTF3 JAG1 CACNA1H TENM2

1.71e-0419065473d94fbae92029745989a8712eed8b99fd84c193
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 MTHFD1 GRAMD2B LDLR

1.74e-04191654f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

JAG2 NTF3 DLK2 TENM2

1.74e-04191654a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THBS1 LARS2 TENM2

1.74e-041916542f733d510a4862565a817f59829d8387d7ea26d9
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

PXDN NTF3 JAG1 CACNA1H

1.74e-04191654fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 THBS1 LARS2 TENM2

1.74e-041916548691eba35793e4e90f93d50c2145847ee51289f7
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PRUNE2 JAG1 SDCBP2

1.74e-04191654b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD2B IFI30 LARS2 BRWD1

1.78e-041926542de242d81dc085ae734eb7d1f091af9a542e0866
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRUNE2 PXDN ARVCF PRSS12

1.78e-041926548899d81306770adda893b5e146df1253971754c5
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PXDN ADAM23 NTF3

1.78e-041926542bfac6b3956265205ca47d06888851ed68b65999
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRUNE2 PXDN ARVCF PRSS12

1.78e-041926545fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD2B IFI30 LARS2 BRWD1

1.78e-04192654ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MRC1 THBS1 PPY IFI30

1.78e-04192654e24a8856ef01ccf69a5e968bd409f9b84befa91e
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PXDN ADAM23 NTF3

1.78e-04192654d525f7f088a53110912600a7c9f6d33b9270d534
ToppCellwk_08-11-Epithelial-Proximal_epithelial-basal_intermediate_|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

JAG2 SULT2B1 GRAMD2B DLK2

1.81e-0419365483d2dd823808a2b5ca1a6889eefb541ec042b24c
ToppCelldroplet-Bladder-nan-24m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG1 ITGA6 SDCBP2 LDLR

1.81e-041936549d7bc71c4ae871aad057d3beb6e06c929ae17203
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RGPD2 THBS1 IFI30 AKAP13

1.81e-041936549fd2bc726bddf414f3de1c7a5ffd9317d3c98e29
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PXDN ADAM23 NTF3

1.85e-04194654c8b9551b93a5aed62154b487db90130604a6125c
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PXDN ITGA6 PLCG1 LARS2

1.85e-04194654f159ef8541d75a4e98468947f231bb463bec922c
ToppCellEC-Arteriolar_ECs|World / Lineage and Cell class

JAG2 PRUNE2 JAG1 SDCBP2

1.85e-0419465438f0c52de252101d4bc8633af80002061635e487
ToppCellRA|World / Chamber and Cluster_Paper

PRUNE2 COL24A1 THBS1 LDLR

1.85e-0419465408f0afbb68a63150fbe107a5337299081c3f69e4
ToppCelldroplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 DLK2 ITGA6 SDCBP2

1.85e-0419465437803f4abf1aa1ad771c9cd293933003d7101e70
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 NTF3 DLK2 TENM2

1.88e-041956546c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARVCF AKAP13 LYAR LARS2

1.92e-04196654c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37|World / Primary Cells by Cluster

COL24A1 TDRD9 NTF3 TENM2

1.96e-0419765400d756bc0231e1b3b88430214338c1059cb11106
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 NTF3 JAG1 CACNA1H

1.96e-04197654bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
Drug6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; MCF7; HT_HG-U133A

ADAM23 TTLL4 ITGA6 AKAP13 CACNA1H PLCG1

2.04e-051966564833_UP
DrugKetoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A

THBS1 ARVCF JAG1 AKAP13 CACNA1H PLCG1

2.10e-051976564751_DN
DrugFK-506; Up 200; 1uM; MCF7; HG-U133A

TTLL4 GRAMD2B CACNA1H PLCG1 LDLR BRWD1

2.10e-05197656284_UP
DrugSalbutamol [18559-94-9]; Down 200; 16.8uM; MCF7; HT_HG-U133A

JAG2 ARVCF ITGA6 AKAP13 CACNA1H ANKMY1

2.10e-051976562306_DN
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; PC3; HG-U133A

MTMR4 SULT2B1 ARVCF DLK2 SRBD1 LDLR

2.10e-051976561925_UP
DrugTicarcillin sodium [4697-14-7]; Up 200; 9.4uM; HL60; HT_HG-U133A

PRUNE2 THBS1 LATS1 GRAMD2B DDX3Y PLCG1

2.16e-051986566146_UP
DiseaseSchizophrenia

JAG2 THBS1 ARVCF MTHFD1 NTF3 JAG1 NCAN BRD1 LARS2

1.16e-04883649C0036341
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTMR6 MTMR4

1.65e-049642DOID:0111225 (implicated_via_orthology)
Diseasetetralogy of Fallot (is_implicated_in)

MTHFD1 JAG1

3.56e-0413642DOID:6419 (is_implicated_in)
DiseaseBipolar Disorder

ARHGEF10 MTHFD1 NCAN PLCG1 BRD1 LARS2

5.87e-04477646C0005586
Diseaselipoprotein measurement, phospholipid measurement

NCAN GPAM LDLR

8.47e-0485643EFO_0004639, EFO_0004732
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MTMR6 MTMR4

1.24e-0324642DOID:10595 (implicated_via_orthology)
DiseaseCarcinoma, Pancreatic Ductal

JAG2 JAG1

1.24e-0324642C0887833
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

NCAN PLCG1 LDLR BRWD1

1.35e-03220644EFO_0004529, EFO_0008317
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

NCAN LDLR

1.46e-0326642OBA_2045191
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

NCAN GPAM PLCG1 LDLR

1.46e-03225644EFO_0008317, EFO_0010351
Diseaseomega-3 polyunsaturated fatty acid measurement

NCAN LDLR BRWD1

2.17e-03118643EFO_0010119
Diseasecysteine-rich with EGF-like domain protein 1 measurement

BRPF1 BRD1

2.20e-0332642EFO_0021870
Diseaseserum alanine aminotransferase measurement

THBS1 PPY NCAN IFI30 GPAM ZNF251 BRWD1

2.71e-03869647EFO_0004735
Diseasesevere acute respiratory syndrome, COVID-19

COL24A1 PXDN ZNF732 ADAM23 TENM2

2.86e-03447645EFO_0000694, MONDO_0100096
Diseasephospholipid measurement

NCAN GPAM LDLR

3.53e-03140643EFO_0004639
Diseaseliver fat measurement

NCAN GPAM

3.95e-0343642EFO_0010821

Protein segments in the cluster

PeptideGeneStartEntry
FKKTDDDRWGHVVCA

BRD1

281

O95696
GWFCVEDDGNHIKKE

ARHGEF10

861

O15013
GKDGDRWIQCSKHDV

ADAM23

641

O75077
CFGGKKAKEEWFHQG

ARVCF

616

O00192
SGHEGAVKCLFFDQW

FBXW10

571

Q5XX13
DWEKGKLEGADHSCT

AKAP13

1156

Q12802
LNWKHCKGISSDGTA

FAM200A

201

Q8TCP9
GKEGHWSKECPIDRS

RBM4

166

Q9BWF3
SGHEGAVKCLFFDQW

FBXW10B

571

O95170
KSSWGEHNCGHKEDA

PRSS12

361

P56730
DFGLCTGFRWTHDSK

LATS1

846

O95835
DWISFGHKFSERCGQ

MTMR6

371

Q9Y217
DDGWKGKTCHSREFQ

JAG2

701

Q9Y219
EKAFKCLTSGEWARH

KMT5B

151

Q4FZB7
KWDDVKFHGDRNTKG

PEX5L

176

Q8IYB4
SNETWKKVECEHGFG

LY75

1641

O60449
DWSFCDGRLRGHEKF

ITGA6

171

P23229
DCFKGKRWGAQKSHA

DDX31

666

Q9H8H2
VKNGCRGIDDKHWNS

NTF3

201

P20783
SDWLDFGHKFGDRCG

MTMR4

441

Q9NYA4
GKRHKEDTLAFSEWG

PPY

66

P01298
TEWDLKRHAEDCGKT

ATMIN

176

O43313
GRWEFKCQHGEEECK

IFI30

111

P13284
WQEGGRCKQSAKDAH

CRAMP1

426

Q96RY5
AWTEFHKKDCGDLVA

ANKMY1

911

Q9P2S6
KDCRHTVWKGSAFAA

BRWD1

116

Q9NSI6
CGKDFWGDDYKNHVK

LYAR

36

Q9NX58
VWKGCKDGVRDESFH

CDC20B

191

Q86Y33
SGWAGKFCDKDEHIC

DLK2

81

Q6UY11
REASKGFHDKDSSGW

DDX3Y

46

O15523
SENWICFHSKVFGKD

GRAMD2B

146

Q96HH9
AKGERWGQASCRAEH

CACNA1H

2246

O95180
TCDKTDWLDGKHVVF

PPIE

251

Q9UNP9
KDGNDKLCWVSAREH

RXYLT1

291

Q9Y2B1
DAVKCTHWAEGGKGA

MTHFD1

781

P11586
GWKGKTCHSRDSQCD

JAG1

696

P78504
GKHEKKTWFESRDFC

MRC1

666

P22897
AFLRKGVCGDWKNHF

SULT2B1

271

O00204
WKGHGDGQSESEKEA

PRUNE2

1316

Q8WUY3
DEHGCSWRSGAKVEQ

LARS2

221

Q15031
LADNHWAKTCEGEGR

BMT2

81

Q1RMZ1
KSLVCGKHWSDGASQ

TDRD9

1021

Q8NDG6
WTACDFADGERKVEH

RGPD2

1421

P0DJD1
RCKHTSEEWGECGFR

GPAM

26

Q9HCL2
CEKDTEGCDRGWHKF

NCAN

1081

O14594
KDGKCECREGWNGEH

TENM2

781

Q9NT68
WGGTCKKEENDDDFT

SRBD1

161

Q8N5C6
DGRDCAGWSSHKAHQ

SDCBP2

156

Q9H190
GHTSGIKKALWCSED

STRAP

141

Q9Y3F4
CSNFHSEIWEKETKG

TASOR

1521

Q9UK61
KGGAFKQTDDGRWAH

BRPF1

336

P55201
YCGKTTSRKAWNEDH

AATF

71

Q9NY61
LSDDCKIQDGSWHKA

COL24A1

1661

Q17RW2
QECDKRFKQDGGWSH

THBS1

426

P07996
GAGCESWDKRKSSFH

SPATA31D1

1121

Q6ZQQ2
VDAGGESHANNTKWK

PXDN

1416

Q92626
SNEKWFHGKLGAGRD

PLCG1

546

P19174
AKHAWCGGNFLEVTE

VAMP7

16

P51809
NECGKAFWEKSHLTR

ZNF33A

331

Q06730
RWTVHTGEKSFGCNE

ZNF251

556

Q9BRH9
EECGKAFGWSTDLNK

ZNF732

421

B4DXR9
SHFKISKRNDDWLGC

TTLL4

626

Q14679
EECGKAFTWSAGLHK

ZNF486

381

Q96H40
APWGGSHTCQKDEKA

UNC79

841

Q9P2D8
RTHNGESLHEWKECG

ZNF266

176

Q14584
HSSWRCDGGPDCKDK

LDLR

211

P01130