Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.26e-0627912311GO:0005096
GeneOntologyMolecularFunctionAMPA glutamate receptor activity

GRIA2 GRIA4

2.24e-0441232GO:0004971
GeneOntologyMolecularFunctionsodium channel activity

GRIA2 SCN4A SCN5A SCN10A

2.95e-04521234GO:0005272
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.03e-0450712311GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.03e-0450712311GO:0030695
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN4A SCN5A SCN10A

5.35e-04261233GO:0005248
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential

SCN5A SCN10A

5.55e-0461232GO:0086006
GeneOntologyBiologicalProcessactivation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

4.22e-1110912111GO:0090630
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

2.06e-0724412111GO:0043547
GeneOntologyBiologicalProcessregulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

4.59e-0633512111GO:0043087
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

TBC1D3E PDCD2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.79e-0549912112GO:0051345
GeneOntologyCellularComponentsodium channel complex

GRIA4 SCN4A SCN5A SCN10A

2.34e-05291224GO:0034706
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN4A SCN5A SCN10A

1.24e-04171223GO:0001518
DomainTBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

5.93e-134912110SM00164
DomainRabGAP-TBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.38e-125312110PF00566
DomainTBC_RABGAP

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

2.04e-125512110PS50086
DomainRab-GTPase-TBC_dom

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

2.04e-125512110IPR000195
DomainNUT

NUTM2A NUTM2G NUTM2B NUTM2F

8.34e-0951214IPR024310
DomainNUT_N

NUTM2A NUTM2G NUTM2B NUTM2F

8.34e-0951214IPR024309
DomainNUT

NUTM2A NUTM2G NUTM2B NUTM2F

8.34e-0951214PF12881
DomainTF_fork_head_CS_2

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

1.75e-08461217IPR030456
DomainTF_fork_head_CS_1

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.04e-08471217IPR018122
DomainFH

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217SM00339
DomainFORK_HEAD_1

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217PS00657
DomainFORK_HEAD_2

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217PS00658
DomainFork_head_dom

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217IPR001766
DomainFORK_HEAD_3

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217PS50039
DomainForkhead

FOXD4L6 FOXI3 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.76e-08491217PF00250
Domain-

ETV3 FOXD4L6 FOXI3 ETV3L FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

1.24e-0521812191.10.10.10
DomainWHTH_DNA-bd_dom

ETV3 FOXD4L6 FOXI3 ETV3L FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

2.84e-052421219IPR011991
DomainNa_channel_asu

SCN4A SCN5A SCN10A

3.08e-05101213IPR001696
DomainNa_trans_assoc

SCN4A SCN5A SCN10A

3.08e-05101213IPR010526
DomainNa_trans_assoc

SCN4A SCN5A SCN10A

3.08e-05101213PF06512
DomainDGCR6

DGCR6 DGCR6L

4.16e-0521212PF07324
DomainGonadal

DGCR6 DGCR6L

4.16e-0521212IPR010849
DomainETV3

ETV3 ETV3L

4.16e-0521212IPR032929
DomainAgo_hook

TNRC6B TNRC6C

1.24e-0431212PF10427
DomainTNRC6_PABC-bd

TNRC6B TNRC6C

1.24e-0431212IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6C

1.24e-0431212IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6C

1.24e-0431212PF16608
DomainChannel_four-helix_dom

CACNA1F SCN4A SCN5A SCN10A

5.08e-04571214IPR027359
Domain-

CACNA1F SCN4A SCN5A SCN10A

5.08e-045712141.20.120.350
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K

1.70e-0999729M46448
PathwayREACTOME_SURFACTANT_METABOLISM

GATA6 ADRA2C DMBT1

2.10e-0423723MM15279
PathwayREACTOME_TGFBR3_EXPRESSION

TCF3 TNRC6B TNRC6C

3.82e-0428723M48253
PathwayREACTOME_SURFACTANT_METABOLISM

GATA6 ADRA2C DMBT1

4.70e-0430723M27566
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN4A SCN5A SCN10A

5.18e-0431723M877
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6C

5.31e-047722M46421
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN4A SCN5A SCN10A

5.70e-0432723M27455
Pubmed

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

9.02e-28111261116863688
Pubmed

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

3.37e-121312667957066
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

3.45e-126126527092474
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3 FOXI1

1.56e-1116126610208738
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

3.20e-11812658530406
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

7.18e-119126512412011
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

DAND5 FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

2.56e-1024126629992973
Pubmed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

TBC1D3E TBC1D3 TBC1D3H TBC1D3D TNRC6C TBC1D3B TBC1D3G TBC1D3F

2.92e-1074126816625196
Pubmed

A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

7.24e-1013126516884697
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

1.68e-091512657689224
Pubmed

Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

1.68e-0915126522045912
Pubmed

Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

2.44e-091612658861101
Pubmed

Genome-scale study of transcription factor expression in the branching mouse lung.

GATA6 FOXD4L6 TFAP2C FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

5.03e-0967126722711520
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

6.43e-091912659895322
Pubmed

Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

8.55e-0920126512812790
Pubmed

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

1.12e-082112659449667
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

1.44e-0822126517389379
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

2.32e-0824126511820816
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

3.57e-0826126515857913
Pubmed

Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

6.38e-0829126522972626
Pubmed

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

TBC1D3 TBC1D3D TBC1D3F

1.85e-074126312359748
Pubmed

Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.

TBC1D3 TBC1D3D TBC1D3F

1.85e-07412638406013
Pubmed

The Tre2 (USP6) oncogene is a hominoid-specific gene.

TBC1D3 TBC1D3D TBC1D3C

4.62e-075126312604796
Pubmed

Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.

TBC1D3 TBC1D3D TBC1D3F

4.62e-07512638471161
Pubmed

FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

FOXD4L6 FOXD4L5 FOXD4L4

4.62e-075126312234674
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN4A SCN5A SCN10A

3.84e-069126316382098
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4L4 FOXD4L1 FOXD4L3

7.50e-0611126312421752
Pubmed

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

SCN5A SCN10A

1.30e-052126224642470
Pubmed

Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.

TEAD4 TFAP2C

1.30e-052126238789684
Pubmed

TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.

TEAD4 TFAP2C

1.30e-052126237169570
Pubmed

Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders.

GRIA2 GRIA4

1.30e-052126221984433
Pubmed

Fibroblast Growth Factor 23 and Placental Growth Factor in Patients with Psoriasis and their Relation to Disease Severity.

PGF FGF23

1.30e-052126227098624
Pubmed

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

SCN5A SCN10A

1.30e-052126215047701
Pubmed

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

DGCR6 DGCR6L

1.30e-052126222832905
Pubmed

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

SCN4A SCN5A

1.30e-052126230944319
Pubmed

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.

SCN5A SCN10A

1.30e-052126231292628
Pubmed

Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.

DGCR6 DGCR6L

1.30e-052126215821931
Pubmed

Investigation of possible epistatic interactions between GRIA2 and GRIA4 variants on clinical outcomes in patients with major depressive disorder.

GRIA2 GRIA4

1.30e-052126223613500
Pubmed

Genetic analysis of GRIA2 and GRIA4 genes in migraine.

GRIA2 GRIA4

1.30e-052126224512576
Pubmed

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

SCN4A SCN5A

1.30e-052126211834499
Pubmed

Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.

DGCR6 DGCR6L

1.30e-052126211157784
Pubmed

A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.

DGCR6 DGCR6L

1.30e-05212629605865
Pubmed

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.

SCN5A SCN10A

1.30e-052126224998131
Pubmed

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

SCN5A SCN10A

1.30e-052126224360055
Pubmed

Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.

SCN5A SCN10A

1.30e-052126232330377
Pubmed

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia.

GRIA2 GRIA4

3.90e-053126222094384
Pubmed

The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.

GRIA4 ICAM5

3.90e-053126228397107
Pubmed

The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.

NUTM2A NUTM2B

3.90e-053126222456610
Pubmed

Superactivation of AMPA receptors by auxiliary proteins.

GRIA2 GRIA4

3.90e-053126226744192
Pubmed

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder.

GRIA2 GRIA4

3.90e-053126222057216
Pubmed

FGF23, NGAL, and Endostatin: the Predictors of Allograft Function in Renal Transplant Recipients.

FGF23 COL18A1

3.90e-053126229528011
Pubmed

Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients.

GRIA2 GRIA4

3.90e-053126218163426
Pubmed

Diversity of human copy number variation and multicopy genes.

TBC1D3E TBC1D3G

3.90e-053126221030649
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN5A

3.90e-053126220038812
Pubmed

Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.

GRIA2 GRIA4

3.90e-053126230692144
Pubmed

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

TNRC6B TNRC6C

3.90e-053126234108231
Pubmed

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.

GRIA2 GRIA4

3.90e-053126229352045
Pubmed

Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

SCN4A SCN5A

3.90e-053126215746172
Pubmed

Developmental clock and mechanism of de novo polarization of the mouse embryo.

TEAD4 TFAP2C

3.90e-053126233303584
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6B TNRC6C

3.90e-053126216880270
Pubmed

Case-control association study of GRIA1, GRIA2 and GRIA4 polymorphisms in bipolar disorder.

GRIA2 GRIA4

3.90e-053126222122651
Pubmed

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

TNRC6B TNRC6C

3.90e-053126231670606
Pubmed

The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.

NUTM2E NUTM2B

3.90e-053126226542179
Pubmed

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.

SCN5A SCN10A

3.90e-053126225998140
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF536 TCF3 RNF44 GATA6 FOXD4L6 TFAP2C ALX4 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

5.70e-057091261122988430
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

FOXD4L4 FOXD4L1 FOXD4L3

6.80e-0522126315233989
Pubmed

A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.

GRIA2 GRIA4

7.78e-054126210688364
Pubmed

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.

GRIA2 GRIA4

7.78e-054126228608780
Pubmed

AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus.

GRIA2 GRIA4

7.78e-05412629221927
Pubmed

Interaction proteomics reveals brain region-specific AMPA receptor complexes.

GRIA2 GRIA4

7.78e-054126225337787
Pubmed

Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.

GRIA2 GRIA4

7.78e-054126217828255
Pubmed

The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.

GRIA2 GRIA4

7.78e-054126224652293
Pubmed

Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family.

GRIA2 GRIA4

7.78e-054126217409242
Pubmed

LARGE, an intellectual disability-associated protein, regulates AMPA-type glutamate receptor trafficking and memory.

GRIA2 GRIA4

7.78e-054126229915039
Pubmed

Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit.

GRIA2 GRIA4

7.78e-054126214561864
Pubmed

Genome-wide association studies of the PR interval in African Americans.

SCN5A SCN10A

7.78e-054126221347284
Pubmed

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.

GRIA2 GRIA4

7.78e-054126210027300
Pubmed

Chromosomal localization of human glutamate receptor genes.

GRIA2 GRIA4

7.78e-05412621319477
Pubmed

AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks.

GRIA2 GRIA4

7.78e-054126212692557
Pubmed

Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.

GRIA2 GRIA4

7.78e-054126212125045
Pubmed

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

TNRC6B TNRC6C

7.78e-054126221063388
Pubmed

Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas.

PGF COL18A1

7.78e-054126220027339
Pubmed

AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+.

GRIA2 GRIA4

7.78e-05412629648857
Pubmed

A census of human transcription factors: function, expression and evolution.

TCF3 GATA6 ETV3 TEAD4 FOXI3 TFAP2C ALX4 FOXD4L4 FOXD4L1 FOXD4L3 SP9 FOXI1

1.19e-049081261219274049
Pubmed

RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.

GRIA2 GRIA4

1.29e-045126236179027
Pubmed

Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16.

DGCR6 DGCR6L

1.29e-045126210395793
Pubmed

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

SCN5A SCN10A

1.29e-045126222706305
Pubmed

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.

GRIA2 GRIA4

1.29e-04512621717158
Pubmed

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.

SCN5A SCN10A

1.29e-045126223463857
Pubmed

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

SCN5A SCN10A

1.29e-045126223872634
Pubmed

Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.

GRIA2 GRIA4

1.29e-045126216129400
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN4A SCN5A

1.29e-045126217724025
Pubmed

Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

GRIA2 GRIA4

1.29e-04512629482932
Pubmed

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.

TNRC6B TNRC6C

1.29e-045126219838187
Pubmed

Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF.

GRIA2 GRIA4

1.29e-045126215797551
Pubmed

Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.

GRIA2 GRIA4

1.93e-046126218922769
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

TNRC6B TNRC6C ANKHD1 GARRE1

2.10e-0480126435803934
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

TCF3 TNRC6B TNRC6C DAZAP1 GARRE1

2.38e-04152126538360978
Pubmed

Molecular constituents of neuronal AMPA receptors.

GRIA2 GRIA4

2.70e-047126215883194
Pubmed

Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells.

GRIA2 GRIA4

2.70e-047126221368048
CytobandEnsembl 112 genes in cytogenetic band chr17q12

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

4.27e-1314912611chr17q12
Cytoband9q21.11

FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3

1.40e-063012649q21.11
Cytoband17q12

TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F

8.36e-0699126517q12
Cytoband10q23.2

NUTM2A NUTM2D

9.89e-0417126210q23.2
GeneFamilySodium voltage-gated channel alpha subunits

SCN4A SCN5A SCN10A

5.89e-0697631203
GeneFamilyGlutamate ionotropic receptor AMPA type subunits

GRIA2 GRIA4

1.04e-0447621200
CoexpressionMORI_MATURE_B_LYMPHOCYTE_UP

DGCR6 FOXD4L6 DGCR6L FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3

6.26e-071061217MM595
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

ZNF536 GATA6 FOXD4L6 SIM2 FOXD4L5 FOXD4L4 ADRA2C FOXD4L1 FOXD4L3 SCN5A

6.43e-0635712110MM828
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

GATA6 FOXD4L6 TEAD4 FOXD4L5 FOXD4L4 FOXD4L1 CELSR3 FOXD4L3

7.83e-062171218MM861
CoexpressionAtlasMesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

SAP25 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ADAMTS1 PCDHA12 PCDHA5 TBC1D3C TBC1D3B COL18A1 TBC1D3G TBC1D3K TBC1D3F

3.50e-1028111414PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05

SAP25 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ADAMTS1 PCDHA12 PCDHA5 TBC1D3C TBC1D3B COL18A1 TBC1D3G TBC1D3K TBC1D3F

3.50e-1028111414PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F

1.32e-09901149PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D EMID1 TBC1D3C TBC1D3B COL18A1 ADRA2C TBC1D3G TBC1D3K TBC1D3F

1.56e-0732011412PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B ADRA2C TBC1D3G TBC1D3K TBC1D3F

2.29e-0721311410PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B ADRA2C TBC1D3G TBC1D3K TBC1D3F

2.29e-0721311410PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasDE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B ADRA2C TBC1D3G TBC1D3K TBC1D3F

7.41e-0724211410PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ETV3 FOXD4L6 ETV3L FOXD4L5 MELTF FOXD4L4 FOXD4L1 FOXD4L3

4.14e-081771268ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 FRMPD1 PGF TMEM132C SCN5A SP9 DMBT1

7.10e-0717612674843af68f013732c28a8b8edad30d5fa0f2b084b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 FRMPD1 PGF TMEM132C MELTF SCN5A SP9

7.10e-07176126795d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ETV3 FOXD4L6 ETV3L FOXD4L4 FOXD4L1 FOXD4L3

8.43e-0616812666dd58fd981750da49afd53796f244e1803cce97f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 FRMPD1 PGF TMEM132C SP9 DMBT1

9.96e-061731266d17e50dc400098374af626803dec1241ec566769
ToppCellwk_20-22-Hematologic-Myeloid-aDC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ETV3 FOXD4L6 ETV3L FOXD4L4 FOXD4L1 FOXD4L3

1.17e-051781266fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 FRMPD1 TMEM132C MELTF SCN5A SP9

1.21e-0517912663b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCelldistal-mesenchymal-Mesothelial-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPHB6 GRIA2 GRIA4 MELTF EPB42 CRB2

2.14e-051981266431bf719ee5cce4c9e8b6b405819b67e98fad3ca
ToppCelldistal-mesenchymal-Mesothelial|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPHB6 GRIA2 GRIA4 MELTF EPB42 CRB2

2.14e-05198126652e3cb45472dd6db31ae533e9ea0c3b550f11496
ToppCellCOVID-19-APC-like-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

GRIA2 PLEKHN1 NTN5 MEIOSIN PADI6

2.96e-0512612659f94291b1db020cc0ebf9c8de4e01bd883295672
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN4A SCN5A SCN10A

5.31e-06101063DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN4A SCN5A SCN10A

5.31e-06101063DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN4A SCN5A SCN10A

9.68e-06121063DOID:0060170 (implicated_via_orthology)
DiseaseBrugada ECG Pattern

SCN5A SCN10A

7.63e-0541062C1721096
Diseaseproline measurement, amino acid measurement

DGCR6 DGCR6L

1.27e-0451062EFO_0005134, EFO_0009773
DiseaseEndometrial Stromal Sarcoma

NUTM2A NUTM2B

1.27e-0451062C0206630
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

1.90e-0461062C0334488
Diseaseelectrocardiography, PR interval

SCN5A SCN10A

2.65e-0471062EFO_0004327, EFO_0004462
Diseaseresponse to platinum based chemotherapy, response to antineoplastic agent

ZNF536 FOXI1

2.65e-0471062EFO_0004647, GO_0097327
Diseasesupraventricular ectopy

SCN5A SCN10A

4.53e-0491062EFO_0009277
DiseaseBrugada Syndrome 1

SCN5A SCN10A

9.72e-04131062C4551804
Diseaseresponse to atorvastatin, myopathy

ZNF536 GARRE1

9.72e-04131062EFO_0004145, EFO_0010124
DiseaseT wave morphology measurement

SCN5A SCN10A

1.13e-03141062EFO_0008398
DiseaseP wave duration

SCN5A SCN10A

1.30e-03151062EFO_0005094
Diseasecentral nervous system disease (implicated_via_orthology)

GRIA2 GRIA4

1.48e-03161062DOID:331 (implicated_via_orthology)
DiseaseRomano-Ward Syndrome

SCN5A SCN10A

1.48e-03161062C0035828
DiseaseBrugada syndrome

SCN5A SCN10A

2.10e-03191062MONDO_0015263
Diseasecortical thickness

VWA5B2 MON2 DAND5 ZNF536 CTTNBP2 TNRC6B ALX4 ETV3L COL18A1 ABCC10 CRB2

2.22e-03111310611EFO_0004840
DiseaseCCL4 measurement

TBC1D3 TBC1D3F

2.33e-03201062EFO_0004751
Diseasesex interaction measurement, COVID-19

ZNF536 PGF

2.57e-03211062EFO_0008343, MONDO_0100096
Diseasecerebellar cortex volume measurement

SIM2 VSIG10L2

2.57e-03211062EFO_0010291
DiseaseATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)

GATA6 SCN5A

2.82e-03221062C1843687
Diseaseglioblastoma (is_implicated_in)

PGF DMBT1

3.35e-03241062DOID:3068 (is_implicated_in)
DiseaseBrugada Syndrome (disorder)

SCN5A SCN10A

3.35e-03241062C1142166

Protein segments in the cluster

PeptideGeneStartEntry
PSWLGNNGAASPVPA

ALX4

306

Q9H161
WQILHPSAPNGGGVL

EPB42

346

P16452
FGLGSALNWPQALPS

AQP2

26

P41181
AGPSAAGGGNQWLSP

LINC00588

131

Q9Y4M8
QAWPGRQSQEGAGLP

TFAP2C

101

Q92754
GGRSIINGNWAVDPP

ADAMTSL4

531

Q6UY14
AFPGWAGQSPGARAA

ALDH16A1

576

Q8IZ83
WPDPAQAQGLGTQLG

BAIAP3

756

O94812
ASVWGNLAGLNTLGP

CELF1

211

Q92879
VANASGASWGPPRGQ

ADRA2C

31

P18825
LWNGSGPQGLATAAA

ETV3

496

P41162
LGEPNAQHPVWGSQG

B3GALT4

111

O96024
FLPPGNSSIWGGLQG

ABCA13

516

Q86UQ4
NWDAGFGGPGASSNP

CPA2

256

P48052
AALGLGGPWQLPAAQ

DGCR6

196

Q14129
QAPGQPGASQWGSRV

DAZAP1

196

Q96EP5
GAQWSPQDPALQGVG

ADAMTS1

226

Q9UHI8
GRWPGPNGGITNFDN

CACNA1F

301

O60840
GQPLQLGTGWLTQGG

ABCC10

1231

Q5T3U5
GPSGWGAILLVNCNP

PADI6

151

Q6TGC4
GNPSTSQAWLGLLAG

PLD3

101

Q8IV08
AANQTWALGPGALPP

DAND5

36

Q8N907
PAAAANPYLWLNGPG

FOXI3

46

A8MTJ6
PSNLWGGQGLLGVSI

GORASP2

86

Q9H8Y8
FSLQAILGNPAGWPV

SLC2A7

186

Q6PXP3
WLGTLFQNPQHGEPG

MST1L

541

Q2TV78
LLAADSQPWGGPFRG

CRB2

751

Q5IJ48
QPGLQVARWGGVALP

FOXD4L4

56

Q8WXT5
QPGLQVARWGGVALP

FOXD4L3

56

Q6VB84
ESQLGNLGIPPGWFS

CARMIL3

931

Q8ND23
NAGDCLANPAVPWGQ

GRIA2

326

P42262
GNAGDCLANPAAPWG

GRIA4

326

P48058
AWLGAAGLPGPQALA

PDCD2

36

Q16342
WRAPPGALNIGLSSN

ICAM5

781

Q9UMF0
SSLLGGAPPWGSLQD

COL18A1

221

P39060
GGIAGIFNWAVAIPP

SLC25A20

216

O43772
SLGPPGSWTLEGLQA

MSLNL

226

Q96KJ4
ILQSQGDSLGPGWPL

MON2

891

Q7Z3U7
AGILRAGPGGPDQQW

PCDHA5

811

Q9Y5H7
LFLGPPQIDVWSGTG

MEIOSIN

341

C9JSJ3
GWLLGSCAASPQTGP

PTGDR2

371

Q9Y5Y4
GSPLAWLSAGSGNVN

GPR3

6

P46089
APGVAGPGGNLSSWE

GATA6

96

Q92908
WNAPTQDGGAPVLGY

IGSF22

721

Q8N9C0
GLWALVNNAGVGLPS

SDR9C7

101

Q8NEX9
VNNAGVGLPSGPNEW

SDR9C7

106

Q8NEX9
PGATPNAGWEGNVRA

GCNT7

326

Q6ZNI0
VGAWPAATPGLNQPA

CTTNBP2

636

Q8WZ74
GWARGQPAAAPQPGL

GLUD1

31

P00367
TASRQGGAPPAWGQQ

FRMPD1

726

Q5SYB0
PNASPLLGSSWGGLI

FGF23

26

Q9GZV9
QAVGAGLSPLGQWPG

GARRE1

766

O15063
QARPPSAAGPAGWAA

C19orf67

341

A6NJJ6
AALGLGGPWQSPAAQ

DGCR6L

196

Q9BY27
DLQGPGAPPAQAWAA

FIZ1

251

Q96SL8
QPGLQVARWGGVALP

FOXD4L1

56

Q9NU39
NASGQGGPGSQIPWR

ENAM

296

Q9NRM1
QWRVLGAGGAGPAPA

EML3

866

Q32P44
GLQDQVGAWGLPGPT

EMID1

191

Q96A84
GPPVQWADVAGQGAL

FIGNL2

386

A6NMB9
GLGGSDLGWLPIPSQ

FOXI1

101

Q12951
LWAALGQRAPGGSPG

CELSR3

2276

Q9NYQ7
LAEGIPANPGNWISG

ETV3L

6

Q6ZN32
PANPGNWISGLAFPD

ETV3L

11

Q6ZN32
PLWGFPSLGQSQGAL

C1orf159

211

Q96HA4
APGNAWFGQGSGPIA

DMBT1

151

Q9UGM3
RQLWLTGAGEGPAPN

PNMA1

306

Q8ND90
AGILRAGPGGPDQQW

PCDHA12

816

Q9UN75
LANVQGPGLTDWLFP

EPPIN

16

O95925
QAPLVWQAPGALCGG

NUTM2A

226

Q8IVF1
QAPLVWQAPGALCGG

NUTM2B

226

A6NNL0
VSQGNAGPWPQGAHG

NUTM2D

221

Q5VT03
QAPLVWQAPGALCGG

NUTM2E

226

B1AL46
SGEQSLAWGLGGPSQ

NUTM2F

721

A1L443
SGEQSLAWGLGGPSQ

NUTM2G

706

Q5VZR2
GVAQGWGPISLNNGL

RTP5

301

Q14D33
GHWNGQQAPPDAGFP

SAP25

61

Q8TEE9
NGNPTGTLGAWGNLL

TNRC6C

141

Q9HCJ0
NSVWGLSPGNPATGN

TNRC6C

246

Q9HCJ0
PQLGGPEASGGLVQW

PLEKHN1

596

Q494U1
PSWCGGLVQGNPNGS

TEX14

176

Q8IWB6
AGWDGLLNPILNSGP

SCN4A

1536

P35499
GSPAGWDVPVGALIQ

MELTF

481

P08582
VSEGAGPWGQPNYLL

TMEM132C

586

Q8N3T6
KWLGLCQPNNPGSGV

FER1L5

266

A0AVI2
GPPALILSAAWASGG

NTN5

86

Q8WTR8
QPGLQVARWGGVALP

FOXD4L5

56

Q5VV16
QPGLQVARWGGVALP

FOXD4L6

56

Q3SYB3
HVAGAPPGTGQDNWL

EPHB6

76

O15197
AQPAWLGFLGPVLQA

HEPH

91

Q9BQS7
LKWAGGANPALAPVL

SMG1

3261

Q96Q15
QLASWPNRGGAPGAP

RNF26

296

Q9BY78
AGWDGLLSPILNTGP

SCN5A

1711

Q14524
CGQLGNWRASPPASA

SIM2

401

Q14190
VPVQLQGGAPWGFTL

SHROOM4

11

Q9ULL8
SSWLGLQQPVAGGGQ

SYAP1

6

Q96A49
PALAQGGPQGSWRFL

TBC1D3L

436

B9A6J9
SPGSWLEVQNPAGGL

SP9

186

P0CG40
QVPANQGWGDGPLSS

ANKHD1

2221

Q8IWZ3
GGPLFNGLHNPDPAW

ANKHD1

2491

Q8IWZ3
PALAQGGPQGSWRFL

TBC1D3B

436

A6NDS4
PALAQGGPQGSWRFL

TBC1D3H

436

P0C7X1
QGLAGTSQWPRAGAP

TCF3

361

P15923
PALAQGGPQGSWRFL

TBC1D3F

436

A6NER0
AVPPQQWALSAGNGS

PGF

21

P49763
AGWDGLLSPILNTGP

SCN10A

1661

Q9Y5Y9
AGLSGGLSQPAGWQS

STT3B

56

Q8TCJ2
GQLWGSPGLEGPLAS

RNF44

31

Q7L0R7
PALAQGGPQGSWRFL

TBC1D3E

436

A0A087X179
RPAVSGFWQGALPGQ

TEAD4

156

Q15561
SGNNPTSGLWINGDP

USP38

956

Q8NB14
GPEPWLGSVQGQRSL

ZNF862

61

O60290
PGIDFRGGPASQQWT

ZNF536

846

O15090
SAPQWPIIAFGGLAG

TMEM19

251

Q96HH6
SLPWALLGPGVGQGD

VWA5B2

1106

Q8N398
PALAQGGPQGSWRFL

TBC1D3D

436

A0A087WVF3
SWPGGAPAASLQFQG

VSIG10L

516

Q86VR7
GGTPPAQLLWLGPQQ

VSIG10L2

526

P0DP72
PALAQGGPQGSWRFL

TBC1D3G

436

Q6DHY5
PALAQGGPQGSWRFL

TBC1D3

436

Q8IZP1
PAAQLGPRGAAGYSW

VPS37C

246

A5D8V6
LQLGQGWGPDARGVP

PSPN

16

O60542
PALAQGGPQGSWRFL

TBC1D3K

436

A0A087X1G2
QWAPTAAGPGGGAER

TYSND1

86

Q2T9J0
PALAQGGPQGSWRFL

TBC1D3I

436

A0A087WXS9
PALAQGGPQGSWRFL

TBC1D3C

436

Q6IPX1
GPQRSALLQAWGGQP

ZFTA

316

C9JLR9
PALNLFGGSTGLGQW

TNRC6B

1761

Q9UPQ9
WQPQSPRPGAGLGAA

FAM53A

86

Q6NSI3
DQQGLSLWGAPQKPG

MYO3B

1231

Q8WXR4