Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	amyloid-beta binding	FZD6 CACNA1A AGER LRP1 ITM2C LILRB5	1.54e-06	102	70	6	GO:0001540
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXE1 ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 CPHXL VEZF1 ZNF658 IRF8 ZNF799 ZNF658B ZNF840P ZNF443 ZNF441 SPIC	2.32e-05	1412	70	16	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXE1 ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 CPHXL VEZF1 ZNF658 IRF8 ZNF799 ZNF658B ZNF840P ZNF443 ZNF441 SPIC	3.46e-05	1459	70	16	GO:0000977
GeneOntologyMolecularFunction	amide binding	FZD6 CACNA1A AGER LRP1 ITM2C LILRB5	6.29e-04	299	70	6	GO:0033218
GeneOntologyMolecularFunction	peptide binding	FZD6 CACNA1A AGER LRP1 ITM2C LILRB5	8.67e-04	318	70	6	GO:0042277
GeneOntologyCellularComponent	interphotoreceptor matrix	EYS RBP3	1.64e-04	6	70	2	GO:0033165
Domain	KRAB	ZNF8 ZNF133 ZSCAN32 ZNF776 ZNF658 ZNF799 ZNF443 ZNF441	4.10e-05	358	67	8	PS50805
Domain	KRAB	ZNF8 ZNF133 ZSCAN32 ZNF776 ZNF658 ZNF799 ZNF443 ZNF441	5.18e-05	370	67	8	IPR001909
Domain	Groucho_enhance	TLE3 TLE4	1.26e-04	5	67	2	IPR009146
Domain	TLE_N	TLE3 TLE4	1.26e-04	5	67	2	PF03920
Domain	Groucho/TLE_N	TLE3 TLE4	1.26e-04	5	67	2	IPR005617
Domain	-	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	1.44e-04	679	67	10	3.30.160.60
Domain	zf-C2H2	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	1.70e-04	693	67	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	1.72e-04	694	67	10	IPR013087
Domain	KRAB	ZNF8 ZNF133 ZNF776 ZNF658 ZNF799 ZNF443 ZNF441	2.90e-04	358	67	7	PF01352
Domain	KRAB	ZNF8 ZNF133 ZNF776 ZNF658 ZNF799 ZNF443 ZNF441	3.49e-04	369	67	7	SM00349
Domain	EGF_Ca-bd_CS	NELL1 EYS JAG1 LRP1	4.08e-04	97	67	4	IPR018097
Domain	ZINC_FINGER_C2H2_2	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	4.15e-04	775	67	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	4.24e-04	777	67	10	PS00028
Domain	EGF_CA	NELL1 EYS JAG1 LRP1	4.41e-04	99	67	4	PS01187
Domain	ASX_HYDROXYL	NELL1 EYS JAG1 LRP1	4.58e-04	100	67	4	PS00010
Domain	Znf_C2H2-like	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	5.12e-04	796	67	10	IPR015880
Domain	Znf_C2H2	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	5.59e-04	805	67	10	IPR007087
Domain	VDCCAlpha1	CACNA1A CACNA1G	5.60e-04	10	67	2	IPR002077
Domain	EGF-type_Asp/Asn_hydroxyl_site	NELL1 EYS JAG1 LRP1	5.71e-04	106	67	4	IPR000152
Domain	ZnF_C2H2	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	5.76e-04	808	67	10	SM00355
Domain	EGF_CA	NELL1 EYS JAG1 LRP1	9.67e-04	122	67	4	SM00179
Domain	EGF-like_Ca-bd_dom	NELL1 EYS JAG1 LRP1	1.03e-03	124	67	4	IPR001881
Domain	Channel_four-helix_dom	CACNA1A NALCN CACNA1G	1.12e-03	57	67	3	IPR027359
Domain	-	CACNA1A NALCN CACNA1G	1.12e-03	57	67	3	1.20.120.350
Domain	Methyltransf_11	TRMT9B AS3MT	1.47e-03	16	67	2	PF08241
Domain	Integrin_alpha_C_CS	ITGA6 ITGAL	1.47e-03	16	67	2	IPR018184
Domain	Methyltransf_11	TRMT9B AS3MT	1.47e-03	16	67	2	IPR013216
Domain	Integrin_alpha-2	ITGA6 ITGAL	1.87e-03	18	67	2	IPR013649
Domain	Integrin_alpha2	ITGA6 ITGAL	1.87e-03	18	67	2	PF08441
Domain	Integrin_alpha	ITGA6 ITGAL	1.87e-03	18	67	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA6 ITGAL	1.87e-03	18	67	2	PS00242
Domain	VWC_out	NELL1 JAG1	2.08e-03	19	67	2	SM00215
Domain	Int_alpha_beta-p	ITGA6 ITGAL	2.08e-03	19	67	2	IPR013519
Domain	Int_alpha	ITGA6 ITGAL	2.08e-03	19	67	2	SM00191
Domain	Prefoldin	DSP TLE3 TLE4	2.21e-03	72	67	3	IPR009053
Domain	Growth_fac_rcpt_	NELL1 EYS JAG1 LRP1	2.39e-03	156	67	4	IPR009030
Domain	EGF-like_CS	NELL1 EYS JAG1 LRP1 ADAM17	2.45e-03	261	67	5	IPR013032
Domain	FG_GAP	ITGA6 ITGAL	2.80e-03	22	67	2	PS51470
Domain	FG-GAP	ITGA6 ITGAL	3.33e-03	24	67	2	PF01839
Domain	FG-GAP	ITGA6 ITGAL	3.33e-03	24	67	2	IPR013517
Domain	Integrin_dom	ITGA6 ITGAL	3.61e-03	25	67	2	IPR032695
Domain	EGF_CA	NELL1 JAG1 LRP1	3.65e-03	86	67	3	PF07645
Domain	hEGF	EYS JAG1	4.51e-03	28	67	2	PF12661
Domain	zf-C2H2_6	ZNF8 ZNF133 ZNF658 ZNF799 ZNF443	5.37e-03	314	67	5	PF13912
Domain	-	PLXNC1 TLE3 CORO1C TLE4 MIOS	6.85e-03	333	67	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PLXNC1 TLE3 CORO1C TLE4 MIOS	7.02e-03	335	67	5	IPR015943
Domain	Ion_trans_dom	CACNA1A NALCN CACNA1G	7.99e-03	114	67	3	IPR005821
Domain	Ion_trans	CACNA1A NALCN CACNA1G	7.99e-03	114	67	3	PF00520
Domain	VWC	NELL1 JAG1	8.20e-03	38	67	2	SM00214
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	TLE3 TLE4 JAG1	1.39e-06	11	72	3	15499562
Pubmed	Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.	LRP1 ADAM17	4.23e-06	2	72	2	20610799
Pubmed	Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.	TLE3 TLE4	4.23e-06	2	72	2	25446531
Pubmed	TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.	TLE3 TLE4	4.23e-06	2	72	2	36801171
Pubmed	Jagged-1 juxtamembrane region: biochemical characterization and cleavage by ADAM17 (TACE) catalytic domain.	JAG1 ADAM17	4.23e-06	2	72	2	23416080
Pubmed	Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event.	JAG1 ADAM17	4.23e-06	2	72	2	20819075
Pubmed	1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.	AGER LRP1	4.23e-06	2	72	2	26820600
Pubmed	Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.	CACNA1A CACNA1G	4.23e-06	2	72	2	20547676
Pubmed	Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.	DSP ITGA6	4.23e-06	2	72	2	33502623
Pubmed	Decreased plasma levels of soluble low density lipoprotein receptor-related protein-1 (sLRP) and the soluble form of the receptor for advanced glycation end products (sRAGE) in the clinical diagnosis of Alzheimer's disease.	AGER LRP1	4.23e-06	2	72	2	23228658
Pubmed	Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3.	SP3 ITGA6	1.27e-05	3	72	2	17652716
Pubmed	Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance.	JAG1 ADAM17	1.27e-05	3	72	2	31506332
Pubmed	RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8.	AGER LRP1	1.27e-05	3	72	2	19539695
Pubmed	Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.	DSP AGER	1.27e-05	3	72	2	37660597
Pubmed	Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.	TLE3 TLE4	1.27e-05	3	72	2	30045946
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	JPH1 ZNF8 SETD5 ATAD5 BTBD18 CAPRIN2 INTS11 OBSL1 LRP1 ITM2C ADAM17	1.78e-05	1116	72	11	31753913
Pubmed	Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.	JAG1 ITGA6	2.53e-05	4	72	2	20940224
Pubmed	Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.	ITGA6 ITGAL	2.53e-05	4	72	2	24982892
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1A CACNA1G	2.53e-05	4	72	2	31800012
Pubmed	TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.	TLE3 TLE4	2.53e-05	4	72	2	8645603
Pubmed	Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.	TLE3 TLE4	2.53e-05	4	72	2	11290324
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1A CACNA1G	2.53e-05	4	72	2	21788606
Pubmed	Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.	CACNA1A CACNA1G	2.53e-05	4	72	2	15175395
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF8 DSP N4BP2 TLE3 TLE4 LRP1 CRTC1	2.59e-05	418	72	7	34709266
Pubmed	Specification of dopaminergic subsets involves interplay of En1 and Pitx3.	TLE3 TLE4 AS3MT	3.67e-05	31	72	3	23863478
Pubmed	Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.	TLE3 TLE4	4.21e-05	5	72	2	1303260
Pubmed	Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures.	TLE3 TLE4	4.21e-05	5	72	2	8989517
Pubmed	HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway.	AGER LRP1	4.21e-05	5	72	2	27563375
Pubmed	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.	TLE3 TLE4	4.21e-05	5	72	2	8365415
Pubmed	Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.	FOXE1 TLE3	4.21e-05	5	72	2	10748198
Pubmed	Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid.	AGER LRP1	4.21e-05	5	72	2	11240025
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPDC1 NUP155 DSP ATAD5 TLE3 CORO1C INTS11 MIOS ITGA6 USP46	5.88e-05	1049	72	10	27880917
Pubmed	Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.	IRF8 ADAM17	6.31e-05	6	72	2	22610140
Pubmed	Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development.	TLE3 TLE4	6.31e-05	6	72	2	8892234
Pubmed	Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.	TLE3 TLE4	6.31e-05	6	72	2	8573724
Pubmed	A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.	TLE3 TLE4	8.82e-05	7	72	2	24024827
Pubmed	Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.	DSP ITGA6	8.82e-05	7	72	2	18292208
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	CACNA1A NELL1 LRP1 CRMP1	1.08e-04	118	72	4	21078624
Pubmed	A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development.	TLE3 TLE4	1.17e-04	8	72	2	10512199
Pubmed	The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.	TLE3 TLE4	1.17e-04	8	72	2	16002402
Pubmed	Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.	TLE3 TLE4	1.17e-04	8	72	2	20735826
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	TLE3 TLE4	1.17e-04	8	72	2	28296634
Pubmed	Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.	JAG1 CAPRIN2	1.17e-04	8	72	2	26177727
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	TLE4 JAG1 RBP3	1.21e-04	46	72	3	21779340
Pubmed	The L1 adhesion molecule is a cellular ligand for VLA-5.	ITGA6 ITGAL	1.51e-04	9	72	2	8557754
Pubmed	A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.	PTPDC1 CRTC1	1.51e-04	9	72	2	24121790
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1G	1.51e-04	9	72	2	16382099
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DSP ITGA6	1.51e-04	9	72	2	12482924
Pubmed	Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.	JAG1 ADAM17	1.51e-04	9	72	2	15574878
Pubmed	Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.	AGER LRP1	1.88e-04	10	72	2	26005850
Pubmed	Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.	TLE3 TLE4	1.88e-04	10	72	2	30571765
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DSP ITGA6	2.30e-04	11	72	2	12802069
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	DSP CACNA1G	2.30e-04	11	72	2	27766308
Pubmed	Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.	TLE3 TLE4	2.30e-04	11	72	2	28800615
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SP3 IBTK CPHXL VEZF1 PLXNC1 TLE3 IRF8 SPIC	2.64e-04	808	72	8	20412781
Pubmed	Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.	AGER LRP1	2.75e-04	12	72	2	22027013
Pubmed	TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.	PLXNC1 TSPYL5	2.75e-04	12	72	2	23518928
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TLE3 TLE4	2.75e-04	12	72	2	11266540
Pubmed	The DNA sequence and analysis of human chromosome 6.	IBTK EYS TMEM217 DSP AGER MAPK13 AGPAT4-IT1	3.05e-04	622	72	7	14574404
Pubmed	Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.	TLE3 TLE4	3.25e-04	13	72	2	22735158
Pubmed	Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.	FZD6 AGER	3.78e-04	14	72	2	38569553
Pubmed	Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.	TRMT9B KLHL25	3.78e-04	14	72	2	17903295
Pubmed	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.	TLE3 TLE4	3.78e-04	14	72	2	17202186
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	IBTK NUP155 ATAD5 N4BP2	4.28e-04	169	72	4	31462741
Pubmed	Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.	TLE3 TLE4	4.36e-04	15	72	2	9291577
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF8 ZNF776 ZNF799 ZNF441	5.54e-04	181	72	4	37372979
Pubmed	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	TMEM217 AGER JAG1	5.79e-04	78	72	3	19204726
Pubmed	TCF and Groucho-related genes influence pituitary growth and development.	TLE3 TLE4	6.33e-04	18	72	2	12907761
Pubmed	Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.	TLE3 TLE4	6.33e-04	18	72	2	33658226
Pubmed	Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.	TLE3 TLE4	6.33e-04	18	72	2	11731482
Pubmed	Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.	DSP ITGA6	7.06e-04	19	72	2	18166659
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	TLE3 TLE4	7.84e-04	20	72	2	11859196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IBTK NUP155 MRC2 CAPRIN2 CRTC1 CACNA1G	8.05e-04	529	72	6	14621295
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	NUP155 VEZF1 ZNF658 DSP MRC2 LRP1 ITGA6 ADAM17 RNF111	8.28e-04	1203	72	9	29180619
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	DSP MRC2 JAG1 LRP1	1.03e-03	214	72	4	22199357
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	IBTK KLHL25	1.04e-03	23	72	2	33130828
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	LRP1 ITGA6	1.13e-03	24	72	2	17452356
Pubmed	Expression of Groucho/TLE proteins during pancreas development.	TLE3 TLE4	1.13e-03	24	72	2	18778483
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	JPH1 FZD6 PLXNC1 JAG1 ITGA6 MAPK13	1.17e-03	569	72	6	30639242
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ITGA6 ADAM17	1.23e-03	25	72	2	17170699
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	DSP CORO1C	1.23e-03	25	72	2	30309841
Pubmed	Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin.	FZD6 JAG1	1.23e-03	25	72	2	30220568
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MRC2 OBSL1 CRTC1	1.26e-03	102	72	3	9734811
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	JPH1 NELL1 ZNF133 DSP CORO1C OBSL1 LRP1 CRMP1 RNF111	1.31e-03	1285	72	9	35914814
Pubmed	A dual role for Ikk alpha in tooth development.	FZD6 JAG1	1.33e-03	26	72	2	14960276
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA6 ITGAL	1.43e-03	27	72	2	31541017
Pubmed	Genomic architecture of Shh-dependent cochlear morphogenesis.	DSP JAG1	1.54e-03	28	72	2	31488567
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	JAG1 LRP1	1.89e-03	31	72	2	32546759
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	IBTK NUP155	1.89e-03	31	72	2	23086144
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	JAG1 ITGA6	1.89e-03	31	72	2	22274697
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	EYS DSP RBP3	2.01e-03	120	72	3	21697133
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	PLXNC1 MRC2 JAG1 LRP1 ITGA6 ADAM17 ITGAL LILRB5	9.78e-06	394	49	8	471
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF8 ZNF133 ZSCAN32 SP3 ZNF776 VEZF1 ZNF658 ZNF799 ZNF443 ZNF441	1.85e-05	718	49	10	28
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA6 ITGAL	1.07e-03	18	49	2	1160
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1G	2.24e-03	26	49	2	253
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	IBTK KLHL25 BTBD18	5.72e-03	134	49	3	861
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_UP	ZSCAN32 SETD5 MRC2 JAG1 LILRB5 ZNF443	1.14e-05	200	66	6	M5003
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXE1 FZD6 TICRR DSP ITGA6	7.95e-06	171	71	5	121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATAD5 N4BP2 ZNF385C ITGAL RNF111	8.41e-06	173	71	5	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATAD5 N4BP2 ZNF385C ITGAL RNF111	8.41e-06	173	71	5	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	IRF8 TSPYL5 ITM2C USP46 ZNF385C	1.02e-05	180	71	5	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FZD6 TRMT9B NALCN DSP ITGA6	1.32e-05	190	71	5	103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FZD6 TRMT9B NALCN DSP ITGA6	1.36e-05	191	71	5	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	FZD6 DSP AGER JAG1 CRMP1	1.65e-05	199	71	5	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
Disease	thiamine measurement	NELL1 N4BP2 CRTC1	1.52e-06	10	70	3	EFO_0010540
Disease	renal fibrosis (is_marker_for)	AGER ADAM17	3.32e-05	4	70	2	DOID:0050855 (is_marker_for)
Disease	migraine disorder	TRMT9B CACNA1A NELL1 MRC2 LRP1 TSPYL5	2.06e-04	357	70	6	MONDO_0005277
Disease	Alzheimer's disease (biomarker_via_orthology)	AGER LRP1 ADAM17	3.59e-04	58	70	3	DOID:10652 (biomarker_via_orthology)
Disease	Adenocarcinoma Of Esophagus	NELL1 CRTC1	4.96e-04	14	70	2	C0279628
Disease	Rheumatoid Arthritis	AGER TLE3 IRF8 ITGA6	7.91e-04	174	70	4	C0003873
Disease	esophageal adenocarcinoma	PTPDC1 CRTC1	8.28e-04	18	70	2	EFO_0000478
Disease	taurocholate measurement	NELL1 ZNF799	1.03e-03	20	70	2	EFO_0010538
Disease	birth weight, parental genotype effect measurement	KLHL25 JAG1 CAPRIN2 ADAM17	1.14e-03	192	70	4	EFO_0004344, EFO_0005939
Disease	cortical thickness	TRMT9B NELL1 SETD5 PLXNC1 CORO1C JAG1 LRP1 AS3MT CRMP1	1.23e-03	1113	70	9	EFO_0004840
Disease	RS-10-hydroxywarfarin measurement	NALCN ITM2C ZNF441	1.66e-03	98	70	3	EFO_0803330
Disease	Carcinoma, Ovarian Epithelial	ATAD5 AGER	2.31e-03	30	70	2	C4721610

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGEGRSEKGHLYCPT	ZNF385C	211	Q66K41
HVSYSPVIRKAGGSG	CACNA1A	2296	O00555
TGPTGVGKTAAVYAC	ATAD5	1131	Q96QE3
YHPGGGSACSSVKVR	AGPAT4-IT1	86	Q9H0P7
TGRIDKSYPTVCGHT	CORO1C	66	Q9ULV4
GVPNKVGTCVSEGSY	AGER	136	Q15109
LGTGCPVTNVTAKGY	OOSP3	56	A0A2R8YFM6
GTYSCAVGTARAGPV	OBSL1	1696	O75147
VEGRPSVKYGCGNSQ	EYS	2206	Q5T1H1
PGYCVQGTVGHKILS	INTS11	351	Q5TA45
FLSQKGQVYTCGHGP	IBTK	191	Q9P2D0
CYSAGHIPDGNTSKL	LRRC53	826	A6NM62
YAPRGGDPHSCKAVT	LRP1	3011	Q07954
NKRHGYGCTVFPDGS	JPH1	311	Q9HDC5
CHPQGSTAGVVYRAG	PLXNC1	156	O60486
YGGKLVGQATTTCPE	IRF8	211	Q02556
GGPEKTITYHGCVAQ	OR2W5P	86	A6NFC9
YSSGKGCNGRVVPTD	DDHD2	71	O94830
VSPTHVGSGAYGSVC	MAPK13	26	O15264
YTIQGNSHGKPCTIP	MRC2	176	Q9UBG0
TLGPVSRSHGGQYRC	LILRB5	281	O75023
SQGPGGKVVTCAHRY	ITGA6	121	P23229
QCKTHGVGSPGSVRQ	PTPDC1	526	A2A3K4
TVQGHSCTCKPGYVG	NELL1	496	Q92832
CVTGPEIVYSGKHNG	NUP155	651	O75694
QHRSKRGGSVGGVCY	ITM2C	46	Q9NQX7
GCRTPTYHLTETGKN	BTBD18	521	B2RXH4
CPRHLKTSGGQGYKF	FZD6	161	O60353
VGPTGSGKSTCYRVL	DNAH1	1861	Q9P2D7
SAIGCKVYVTGGRGS	KLHL25	336	Q9H0H3
GRTVGSGKVYPTVHT	CACNA1G	581	O43497
VDKHGRQADSCPYGT	CRTC1	121	Q6UUV9
SSCRAVHLPSGGQYK	CRYGS	81	P22914
VRRASSKGGGGYTCQ	DSP	161	P15924
GPTKRCQVIYNGGIT	AS3MT	266	Q9HBK9
QQCYKRGGTSGGPRA	CAPRIN2	921	Q6IMN6
HRPKSSNCYGSGSGQ	LCE4A	71	Q5TA78
SGHCPYSTAQKAVGK	CRMP1	331	Q14194
QSSYLVTGTEKHPGC	CPHXL	206	A0A1W2PPM1
RHTGKGYQKPLSTCG	OR5B17	226	Q8NGF7
VRYISSNVCGPHGKC	JAG1	591	P78504
ATTTGYQPAGCTGAR	FOXE1	256	O00358
GTTQRHGCRGLPYAT	SETD5	46	Q9C0A6
GTGHCLPVTLRGSNY	ITGAL	76	P20701
HVKGNSSCYGVLPTE	SPIC	46	Q8N5J4
AYVGSPRANSHGGVC	ADAM17	351	P78536
RTHTGEKPYGCQQCG	ZNF441	551	Q8N8Z8
HSTPGKSRGQTYICQ	TICRR	1631	Q7Z2Z1
NVHEGPCGISYKTFS	XPNPEP1	496	Q9NQW7
VRSHEGGITKPYTCS	VEZF1	221	Q14119
HTGERPYQCGQCGKS	ZSCAN32	571	Q9NX65
HCTGGQVSGIPYIIS	RBP3	171	P10745
GKSISYSCSAVPHQG	MIOS	741	Q9NXC5
GASQGTIERCTYPHK	RNF111	896	Q6ZNA4
SNPTRHVYTGGKGCV	TLE4	496	Q04727
PGCGKVYGKTSHLRA	SP3	626	Q02447
NLGIGHTRYATTGKC	PPAT	86	Q06203
KGTHTGERPYQCTTC	ZNF840P	596	A6NDX5
SSLNCYIRVGAGHKP	ZNF799	116	Q96GE5
GYAPHVRSCKPNTDG	RXFP1	381	Q9HBX9
NPTRHVYTGGKGCVK	TLE3	496	Q04726
NGCGRSYKSPLIGHQ	ZNF658	471	Q5TYW1
THTGEKPYVCGVCGR	ZNF133	431	P52736
GSGPNRGHYITIVKS	USP46	306	P62068
SSLNCYIRVGAGHKP	ZNF443	116	Q9Y2A4
RTHTGEKPYTCSVCG	ZNF8	361	P17098
QCGSKRSHSVGYEPA	TRMT9B	206	Q9P272
HLGNGSCTEITPKYR	TMEM217	36	Q8N7C4
KEYGCGPSGQVVSRS	TSPYL5	311	Q86VY4
NGCGRSYKSPLIGHQ	ZNF658B	231	Q4V348
LQGGKTHYICGESTI	ZNF776	201	Q68DI1
GTFTYHCVVNDTKPG	NALCN	201	Q8IZF0
GKPYLSVITGRGNHS	N4BP2	1721	Q86UW6