Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NCOA3 ZBTB48 ZNF556 ZNF846 ZBTB43 NPAS3 ZNF521 ZNF317 SKIL ZNF709 ZNF791 ZNF879 ZNF77	1.64e-04	1412	58	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NCOA3 ZBTB48 ZNF556 ZNF846 ZBTB43 NPAS3 ZNF521 ZNF317 SKIL ZNF709 ZNF791 ZNF879 ZNF77	2.27e-04	1459	58	13	GO:0000977
GeneOntologyMolecularFunction	double-stranded telomeric DNA binding	HMBOX1 ZBTB48	2.95e-04	9	58	2	GO:0003691
GeneOntologyBiologicalProcess	symbiont-mediated disruption of host anatomical structure	CSNK2A1 CSNK2B	2.33e-05	3	58	2	GO:0052111
GeneOntologyBiologicalProcess	symbiont-mediated disruption of host cell PML body	CSNK2A1 CSNK2B	2.33e-05	3	58	2	GO:0075342
GeneOntologyBiologicalProcess	symbiont-mediated disruption of host cellular anatomical structure	CSNK2A1 CSNK2B	2.33e-05	3	58	2	GO:0052008
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2B CSNK2A3	8.09e-08	4	58	3	GO:0005956
GeneOntologyCellularComponent	serine palmitoyltransferase complex	ORMDL3 SPTSSA	2.10e-04	8	58	2	GO:0017059
GeneOntologyCellularComponent	PML body	HMBOX1 CSNK2A1 CSNK2B SKIL	4.03e-04	125	58	4	GO:0016605
GeneOntologyCellularComponent	palmitoyltransferase complex	ORMDL3 SPTSSA	4.09e-04	11	58	2	GO:0002178
Domain	zf-C2H2_6	ZBTB48 ZNF556 ZNF846 ZNF521 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	3.09e-07	314	55	9	PF13912
Domain	ZINC_FINGER_C2H2_2	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 TRMT1L ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.32e-05	775	55	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 TRMT1L ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.35e-05	777	55	11	PS00028
Domain	Znf_C2H2-like	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 TRMT1L ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.69e-05	796	55	11	IPR015880
Domain	Znf_C2H2	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 TRMT1L ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.88e-05	805	55	11	IPR007087
Domain	ZnF_C2H2	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 TRMT1L ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.94e-05	808	55	11	SM00355
Domain	-	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	2.51e-05	679	55	10	3.30.160.60
Domain	zf-C2H2	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	2.99e-05	693	55	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	3.03e-05	694	55	10	IPR013087
Domain	KRAB	ZNF556 ZNF846 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	8.25e-05	358	55	7	PS50805
Domain	KRAB	ZNF556 ZNF846 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	8.25e-05	358	55	7	PF01352
Domain	KRAB	ZNF556 ZNF846 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	9.96e-05	369	55	7	SM00349
Domain	KRAB	ZNF556 ZNF846 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	1.01e-04	370	55	7	IPR001909
Domain	Lipase/vitellogenin	LIPG PNLIPRP3	3.77e-04	10	55	2	IPR013818
Domain	TAG_lipase	LIPG PNLIPRP3	3.77e-04	10	55	2	IPR000734
Domain	Lipase_LIPH	LIPG PNLIPRP3	3.77e-04	10	55	2	IPR016272
Domain	Lipase	LIPG PNLIPRP3	3.77e-04	10	55	2	PF00151
Domain	Lipase_N	LIPG PNLIPRP3	3.77e-04	10	55	2	IPR033906
Domain	PLAT	LIPG PNLIPRP3	1.72e-03	21	55	2	PS50095
Domain	-	LIPG PNLIPRP3	1.72e-03	21	55	2	2.60.60.20
Domain	PLAT	LIPG PNLIPRP3	1.72e-03	21	55	2	PF01477
Domain	PLAT/LH2_dom	LIPG PNLIPRP3	1.72e-03	21	55	2	IPR001024
Domain	PAS	NCOA3 NPAS3	2.45e-03	25	55	2	PF00989
Domain	PAS_fold	NCOA3 NPAS3	2.45e-03	25	55	2	IPR013767
Domain	LIPASE_SER	LIPG PNLIPRP3	2.64e-03	26	55	2	PS00120
Domain	DEATH-like_dom	HMBOX1 NLRP9 UNC5D	3.10e-03	99	55	3	IPR011029
Domain	PAS	NCOA3 NPAS3	3.99e-03	32	55	2	SM00091
Domain	PAS	NCOA3 NPAS3	4.50e-03	34	55	2	IPR000014
Domain	PAS	NCOA3 NPAS3	4.50e-03	34	55	2	PS50112
Domain	Bromodomain	ZMYND11 BRWD1	5.59e-03	38	55	2	PF00439
Domain	BROMODOMAIN_2	ZMYND11 BRWD1	6.49e-03	41	55	2	PS50014
Domain	BROMO	ZMYND11 BRWD1	6.80e-03	42	55	2	SM00297
Domain	Bromodomain	ZMYND11 BRWD1	6.80e-03	42	55	2	IPR001487
Domain	-	ZMYND11 BRWD1	6.80e-03	42	55	2	1.20.920.10
Domain	WW	DMD PLEKHA7	8.46e-03	47	55	2	PF00397
Domain	WW	DMD PLEKHA7	8.81e-03	48	55	2	SM00456
Pathway	KEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT	CSNK2A1 CSNK2B CSNK2A3	7.94e-06	13	44	3	M47763
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	CSNK2A1 CSNK2B	2.63e-04	8	44	2	M27100
Pathway	REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES	CSNK2A1 CSNK2B	2.63e-04	8	44	2	MM14895
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	CSNK2A1 CSNK2B	3.38e-04	9	44	2	MM14792
Pathway	REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES	CSNK2A1 CSNK2B	5.14e-04	11	44	2	M27182
Pathway	REACTOME_RECEPTOR_MEDIATED_MITOPHAGY	CSNK2A1 CSNK2B	5.14e-04	11	44	2	M27789
Pathway	WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION	EPHB2 CMKLR1	6.16e-04	12	44	2	M45559
Pathway	KEGG_MEDICUS_REFERENCE_BLOCKING_UBIQUITINATION_OF_H2AK119_BY_CK2	CSNK2A1 CSNK2B	6.16e-04	12	44	2	M47943
Pathway	REACTOME_RECEPTOR_MEDIATED_MITOPHAGY	CSNK2A1 CSNK2B	6.16e-04	12	44	2	MM15525
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	CSNK2A1 CSNK2B	1.11e-03	16	44	2	M48235
Pathway	PID_DNA_PK_PATHWAY	CSNK2A1 CSNK2B	1.11e-03	16	44	2	M42
Pathway	PID_NFKAPPAB_ATYPICAL_PATHWAY	CSNK2A1 CSNK2B	1.26e-03	17	44	2	M26
Pathway	WP_BREAST_CANCER_PATHWAY	NCOA3 CSNK2A1 CSNK2B CSNK2A3	1.32e-03	154	44	4	M39739
Pathway	REACTOME_SIGNAL_TRANSDUCTION_BY_L1	CSNK2A1 CSNK2B	1.57e-03	19	44	2	MM15113
Pathway	REACTOME_SIGNAL_TRANSDUCTION_BY_L1	CSNK2A1 CSNK2B	1.93e-03	21	44	2	M878
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A1 CSNK2B CSNK2A3	4.40e-09	3	58	3	11092945
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A1 CSNK2B CSNK2A3	4.40e-09	3	58	3	12102635
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A1 CSNK2B CSNK2A3	1.53e-07	7	58	3	11239457
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A1 CSNK2B CSNK2A3	2.45e-07	8	58	3	12393879
Pubmed	Expression of casein kinase 2 during mouse embryogenesis.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	8184654
Pubmed	Direct regulation of microtubule dynamics by protein kinase CK2.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	14634006
Pubmed	The interaction of CK2alpha and CK2beta, the subunits of protein kinase CK2, requires CK2beta in a preformed conformation and is enthalpically driven.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	18824508
Pubmed	Characterization of the oligomeric states of the CK2 α2β2 holoenzyme in solution.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	28572157
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	2.73e-06	2	58	2	14646071
Pubmed	Examination of transcript amounts and activity of protein kinase CK2 in muscle lysates of different types of human muscle pathologies.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	18553059
Pubmed	Casein kinase II phosphorylates the C-terminal region of Lif1 to promote the Lif1-Xrs2 interaction needed for non-homologous end joining.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	29778533
Pubmed	Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	30655572
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	2.73e-06	2	58	2	1577469
Pubmed	Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation.	CSNK2B CSNK2A3	2.73e-06	2	58	2	7942276
Pubmed	Recombinant human casein kinase II. A study with the complete set of subunits (alpha, alpha' and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	8119294
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	2.73e-06	2	58	2	12860116
Pubmed	Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	22506723
Pubmed	Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	16806200
Pubmed	Transcriptional coordination of the genes encoding catalytic (CK2alpha) and regulatory (CK2beta) subunits of human protein kinase CK2.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	11827174
Pubmed	Consequences of CK2 signaling to the nuclear matrix.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	11827176
Pubmed	Characterization of CK2 holoenzyme variants with regard to crystallization.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	11827171
Pubmed	Response of cancer cells to molecular interruption of the CK2 signal.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	11827168
Pubmed	Active form of the protein kinase CK2 α2β2 holoenzyme is a strong complex with symmetric architecture.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	24175891
Pubmed	Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	11574463
Pubmed	Protein kinase CK2 contributes to placental development: physiological and pathological implications.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	31832700
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	2.73e-06	2	58	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	2.73e-06	2	58	2	8420794
Pubmed	[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma].	CSNK2A1 CSNK2B	2.73e-06	2	58	2	18062282
Pubmed	Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders.	CSNK2A1 CSNK2B	2.73e-06	2	58	2	36833176
Pubmed	HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	17391060
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	8.19e-06	3	58	2	15684395
Pubmed	Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10381337
Pubmed	The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	7491787
Pubmed	Biochemical characterization of casein kinase II as a protein kinase responsible for stimulation of HIV-1 protease in vitro.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10964683
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	8.19e-06	3	58	2	2174700
Pubmed	Biochemical characterization of recombinant HIV-1 reverse transcriptase (rRT) as a glycyrrhizin-binding protein and the CK-II-mediated stimulation of rRT activity potently inhibited by glycyrrhetinic acid derivative.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	9881639
Pubmed	Protein kinase CK2 regulates CDC25B phosphatase activity.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	12527891
Pubmed	Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	35871297
Pubmed	Heat-shock protein 90 complexes in resting and thrombin-activated platelets.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	12220519
Pubmed	Casein kinase II (CK-II)-mediated stimulation of HIV-1 reverse transcriptase activity and characterization of selective inhibitors in vitro.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10549869
Pubmed	Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	8548340
Pubmed	The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	16225457
Pubmed	Phosphorylation by casein kinase 2 regulates Nap1 localization and function.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	18086883
Pubmed	The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	8107101
Pubmed	Adiponectin receptor 1 interacts with both subunits of protein kinase CK2.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	21750988
Pubmed	Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	31779225
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A1 CSNK2A3	8.19e-06	3	58	2	1766873
Pubmed	Interactions between the subunits of casein kinase II.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	7768894
Pubmed	Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2').	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10984616
Pubmed	CK2 phosphorylates AP-2α and increases its transcriptional activity.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	21777522
Pubmed	Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	8349691
Pubmed	Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	25788269
Pubmed	Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10512750
Pubmed	Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	11861906
Pubmed	Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	9571630
Pubmed	Casein kinase 2 binds to and phosphorylates BRCA1.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10403822
Pubmed	Structural consequences of phosphorylation of two serine residues in the cytoplasmic domain of HIV-1 VpU.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	18186541
Pubmed	Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	9188720
Pubmed	The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	12470599
Pubmed	Biochemical characterization of HIV-1 Rev as a potent activator of casein kinase II in vitro.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	9654140
Pubmed	Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	1541298
Pubmed	Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	11827178
Pubmed	Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	11827177
Pubmed	Protein kinase CK2: signaling and tumorigenesis in the mammary gland.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	11827167
Pubmed	HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	11827166
Pubmed	A New Role Discovered for a Well-Known Clock Protein.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	26562283
Pubmed	The role of protein kinase CK2 in the regulation of the insulin production of pancreatic islets.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	20849816
Pubmed	Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	22562247
Pubmed	The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	31941600
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A1 CSNK2A3	8.19e-06	3	58	2	20625391
Pubmed	Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity.	CSNK2A1 CSNK2B	8.19e-06	3	58	2	10944435
Pubmed	Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	27920254
Pubmed	The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	23816881
Pubmed	Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	9185604
Pubmed	CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	19542537
Pubmed	Cdk9 phosphorylates p53 on serine 392 independently of CKII.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	16741955
Pubmed	Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	20664522
Pubmed	Bovine prion protein as a modulator of protein kinase CK2.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	11062072
Pubmed	KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	19011756
Pubmed	Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	7794916
Pubmed	Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	28031292
Pubmed	Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': implications for pathological roles of CK2 in promoting cancer cell survival.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	23599180
Pubmed	Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	10398585
Pubmed	Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	12902976
Pubmed	Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	11378439
Pubmed	Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	19039329
Pubmed	Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	20719947
Pubmed	Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	30279146
Pubmed	Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	15218032
Pubmed	Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	23058914
Pubmed	p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	21968188
Pubmed	Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	15723517
Pubmed	Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	14645218
Pubmed	A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	19299560
Pubmed	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	32385263
Pubmed	CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	8943850
Pubmed	Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	15225637
Pubmed	The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	7689229
Pubmed	Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	9092824
Pubmed	Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.	CSNK2A1 CSNK2B	1.64e-05	4	58	2	10799509
Interaction	CFAP97 interactions	BCAP31 CSNK2A1 CSNK2B TRMT1L CSNK2A3	3.55e-07	57	52	5	int:CFAP97
Interaction	EFCAB14 interactions	CSNK2A1 CSNK2B CSNK2A3	1.92e-06	10	52	3	int:EFCAB14
Interaction	LYST interactions	CSNK2A1 CSNK2B ZNF521 CSNK2A3	1.05e-05	53	52	4	int:LYST
Interaction	MAPK14 interactions	NCOA3 BCAP31 LIPG CSNK2A1 CSNK2B FASTKD5 TRMT1L	3.24e-05	353	52	7	int:MAPK14
Interaction	GPATCH2L interactions	ZBTB48 CSNK2A1 CSNK2B CSNK2A3	3.56e-05	72	52	4	int:GPATCH2L
Interaction	MRPS24 interactions	ZBTB48 ZNF556 FASTKD5 SARDH TUFM ARMC8	7.50e-05	276	52	6	int:MRPS24
Interaction	ANKRD36 interactions	HMBOX1 CSNK2A1 CSNK2A3	7.62e-05	32	52	3	int:ANKRD36
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF556 ZNF846 ZNF317 ZNF709 ZNF791 ZNF77	5.05e-04	797	58	6	chr19p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB48 ZNF556 ZNF846 ZBTB43 ZNF521 ZNF317 ZNF709 ZNF791 ZNF879 ZNF77	2.05e-06	718	39	10	28
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPG PNLIPRP3	1.02e-03	22	39	2	464
GeneFamily	Olfactory receptors, family 13	OR13C7 OR13C6P	1.11e-03	23	39	2	162
ToppCell	Sepsis-Int-URO-Others-RBC\|Int-URO / Disease, condition lineage and cell class	GDF7 ZNF521 CMKLR1 ZNF709 WDR62	5.46e-06	198	57	5	29203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCell	Sepsis-Int-URO-Others\|Int-URO / Disease, condition lineage and cell class	GDF7 ZNF521 CMKLR1 ZNF709 WDR62	5.46e-06	198	57	5	67f721ea8e60042317ba12efd584f56b07cfb29d
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG ZBTB43 UNC5D SHISA6	7.11e-05	173	57	4	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG ZBTB43 UNC5D SHISA6	7.11e-05	173	57	4	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PCLO HHAT WDR62 CFAP65	7.44e-05	175	57	4	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PCLO HHAT WDR62 CFAP65	7.44e-05	175	57	4	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG DMD SHISA6 SEMA4C	8.29e-05	180	57	4	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG DMD SHISA6 SEMA4C	8.29e-05	180	57	4	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	DPYSL3 PCLO NPAS3 UNC5D	8.66e-05	182	57	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPAS3 ADAMTS20 SHISA6 PNLIPRP3	8.84e-05	183	57	4	7961e05c6e9964da159059c6bfb4f7e7e14308c2
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO ADAMTS20 DMD UNC5D	9.03e-05	184	57	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO ADAMTS20 DMD UNC5D	9.03e-05	184	57	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO ADAMTS20 DMD UNC5D	9.03e-05	184	57	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PCLO NAV1 ADAMTS20 UNC5D	9.41e-05	186	57	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	CV-Severe-3\|Severe / Virus stimulation, Condition and Cluster	CMKLR1 SARDH SKIL SEMA4C	9.61e-05	187	57	4	68cb43a73945f5e252530da25613f6b3f484b4d5
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	DPYSL3 NPAS3 ZNF521 DMD	9.61e-05	187	57	4	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	LV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	EPHB2 DPYSL3 AASS ZNF521	1.00e-04	189	57	4	3922135d1f6fc768d71ba3b465585fead6ea68a8
Drug	Isoxicam [34552-84-6]; Up 200; 12uM; PC3; HT_HG-U133A	EPHB2 NCOA3 DPYSL3 ZBTB43 TRMT1L WDR62	8.56e-06	196	56	6	1820_UP
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; PC3; HT_HG-U133A	DPYSL3 AASS SKIL ARMC8 SEMA4C BRWD1	8.81e-06	197	56	6	7149_UP
Disease	insulin sensitivity measurement	SHISA6 ARMC8	8.11e-04	23	54	2	EFO_0004471
Disease	intellectual disability (is_implicated_in)	DMD WDR62	1.38e-03	30	54	2	DOID:1059 (is_implicated_in)
Disease	Adult T-Cell Lymphoma/Leukemia	CSNK2A1 CSNK2B	1.48e-03	31	54	2	C0023493
Disease	Squamous cell carcinoma	NCOA3 CSNK2A1 CSNK2B	1.54e-03	124	54	3	C0007137
Disease	macrophage inflammatory protein 1a measurement	DPYSL3 CSNK2B	1.57e-03	32	54	2	EFO_0008218
Disease	phosphatidylcholine 38:2 measurement	SCGB2A1 LIPG	1.88e-03	35	54	2	EFO_0010384
Disease	language measurement	NCOA3 HHAT ZNF521	1.92e-03	134	54	3	EFO_0007797
Disease	myocardial infarction (biomarker_via_orthology)	CSNK2A1 CSNK2B CSNK2A3	3.17e-03	160	54	3	DOID:5844 (biomarker_via_orthology)
Disease	Gastrointestinal Stromal Sarcoma	HHAT DMD	3.37e-03	47	54	2	C3179349

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPRMQYHALSLAMHG	ALG1	46	Q9BT22
DVHTHFQMPYKGMTT	DPYSL3	71	Q14195
HTPFMHIGMAHNYRN	AASS	176	Q9UDR5
VAKGHKMHYPMVEYC	DMD	3346	P11532
KYHVMAPALSFHMSP	ADAMTS20	426	P59510
KKFPQMTSYHRMLLH	R3HDM2	191	Q9Y2K5
VSNSHLHMPMYFFLG	OR13C6P	51	Q8NH95
VSNSHLHMPMYFFLG	OR13C7	51	P0DN81
PTMGHFADRFHFKNM	PNLIPRP3	321	Q17RR3
ALIHFQGVGYNPHMM	CFAP65	1396	Q6ZU64
PGAMEHFHMKLFRAQ	BCAP31	86	P51572
KMSPTRYHANSMGQR	HMBOX1	131	Q6NT76
LQHYTSGHMTPGMKI	EPHB2	581	P29323
IQMNGKTMHYIFPHA	PCLO	4481	Q9Y6V0
GMPFRVYHYQMKIHV	LIPG	341	Q9Y5X9
RHKPFVSHFMPVMFS	TUFM	366	P49411
QGLRLHSPMYMFLQH	OR11L1	51	Q8NGX0
MYLRPNSSHFMGTDK	OR5B12	256	Q96R08
MAHLMYMHAIYSSIP	HHAT	261	Q5VTY9
YMGHSHVKLQLAAMF	ARMC8	606	Q8IUR7
YCHSMGIMHRDVKPH	CSNK2A3	146	Q8NEV1
LETMLGGPQYVKHHM	FASTKD5	566	Q7L8L6
MHIGPLYPHAFKTVM	HEATR5B	2011	Q9P2D3
TGFPHMLFMVHPEYR	CSNK2B	161	P67870
TAFPGTMYQHIKMHR	BRWD1	166	Q9NSI6
YCHSMGIMHRDVKPH	CSNK2A1	146	P68400
HNMGMYIFLHTVKGT	ORMDL3	56	Q8N138
HHPMGMLYRYKVQVE	NUP210L	476	Q5VU65
FGSAIIMYMAPKSRH	OR2A1;	251	Q8NGT9
IDRHLHTPMYFFLSM	OR10J6P	51	Q8NGY7
RAHYSHTMPMRSPSK	NAV1	351	Q8NEY1
DHASSYHMKPLRMAR	SZT2	3116	Q5T011
YNIHRHSIKGMNMPK	TRMT1L	636	Q7Z2T5
GMFAPQTFVMHSHRS	SKIL	296	P12757
FRNGSVVPHHFMMSL	GDF7	81	Q7Z4P5
VVPHHFMMSLYRSLA	GDF7	86	Q7Z4P5
FAHQGNPAVYSMVHM	NCOA3	1381	Q9Y6Q9
HVDRRSMPSMGYMTH	PLEKHA7	626	Q6IQ23
LDRYRMSKMHSHPSA	SHISA6	436	Q6ZSJ9
MLYHHVHRLNMSGPF	NPAS3	871	Q8IXF0
ILRNMGPHHSMKTEY	SEMA4C	191	Q9C0C4
TMSYPMRSVQHRHFR	SGSH	371	P51688
TGYVFMPQHIMAILH	SPTSSA	51	Q969W0
MAGVKVPLVAMHHAY	SARDH	281	Q9UL12
HSQMDPVGYSRHMVV	CMKLR1	206	Q99788
GKLAMQKHYFMLRHP	NLRP9	276	Q7RTR0
HYTRPMYSKPSIMAH	ZBTB43	226	O43298
RVHMVSHTGEMPYKC	ZBTB48	366	P10074
FRYPSSLRAHMRMHT	ZNF77	361	Q15935
SLRAHMRMHTGEKPY	ZNF77	366	Q15935
IYPTSFQGHMRMHTG	ZNF791	506	Q3KP31
FQGHMRMHTGEKPYK	ZNF791	511	Q3KP31
NMHMRTHTGEKPYAC	ZNF846	466	Q147U1
HRTLKNFGLMMHTVY	SCGB2A1	71	O75556
REHMQTHLGPVKHYM	ZNF521	946	Q96K83
VHMIMHAGGRPYECK	ZNF556	276	Q9HAH1
HSFSTMHPRNKMPYI	UNC5D	516	Q6UXZ4
FRGHMRMHTGEKPYK	ZNF709	211	Q8N972
ISLPSYRRHMIMHTG	ZNF709	346	Q8N972
YRRHMIMHTGNGPYK	ZNF709	351	Q8N972
VAFSPNMKHIVSMGY	WDR62	161	O43379
RITKYMSRVHGMHPK	ZMYND11	36	Q15326
SLMTHMRIHTGEKPY	ZNF879	526	B4DU55
RPHLTQHMSMYDGRK	ZNF317	206	Q96PQ6