Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaryl hydrocarbon receptor binding

ARNT ARNT2

1.80e-06952GO:0017162
GeneOntologyMolecularFunctionprotein heterodimerization activity

ARNT ARNT2

3.81e-0339852GO:0046982
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

ARNT ARNT2

4.17e-0341752GO:0061629
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC46A2 ABCA10

5.43e-0347752GO:0022804
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

ARNT ARNT2

8.00e-0358252GO:0140297
GeneOntologyMolecularFunctiontranscription factor binding

ARNT ARNT2

1.32e-0275352GO:0008134
GeneOntologyCellularComponentaryl hydrocarbon receptor complex

ARNT ARNT2

1.28e-06852GO:0034751
GeneOntologyCellularComponentreceptor complex

ARNT ARNT2

7.29e-0358152GO:0043235
GeneOntologyCellularComponenttranscription regulator complex

ARNT ARNT2

7.66e-0359652GO:0005667
DomainNuc_translocat

ARNT ARNT2

1.60e-06852IPR001067
DomainPAS_3

ARNT ARNT2

1.45e-052352PF08447
DomainPAS_fold_3

ARNT ARNT2

1.45e-052352IPR013655
DomainPAS-assoc_C

ARNT ARNT2

1.58e-052452IPR000700
DomainPAS

ARNT ARNT2

1.72e-052552PF00989
DomainPAS_fold

ARNT ARNT2

1.72e-052552IPR013767
DomainPAC

ARNT ARNT2

1.86e-052652IPR001610
DomainPAC

ARNT ARNT2

1.86e-052652SM00086
DomainPAC

ARNT ARNT2

1.86e-052652PS50113
DomainPAS

ARNT ARNT2

2.83e-053252SM00091
DomainPAS

ARNT ARNT2

3.21e-053452IPR000014
DomainPAS

ARNT ARNT2

3.21e-053452PS50112
Domain-

ARNT ARNT2

3.34e-04109524.10.280.10
DomainHLH

ARNT ARNT2

3.46e-0411152PF00010
DomainHLH

ARNT ARNT2

3.78e-0411652SM00353
DomainBHLH

ARNT ARNT2

3.84e-0411752PS50888
DomainbHLH_dom

ARNT ARNT2

3.91e-0411852IPR011598
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

ARNT ARNT2

6.04e-07542MM16637
PathwayREACTOME_ARYL_HYDROCARBON_RECEPTOR_SIGNALLING

ARNT ARNT2

9.05e-07642M27793
PathwayREACTOME_ARYL_HYDROCARBON_RECEPTOR_SIGNALLING

ARNT ARNT2

1.27e-06742MM15528
PathwayREACTOME_NPAS4_REGULATES_EXPRESSION_OF_TARGET_GENES

ARNT ARNT2

1.39e-052242M46437
PathwayREACTOME_XENOBIOTICS

ARNT ARNT2

1.52e-052342M5372
PathwayREACTOME_XENOBIOTICS

ARNT ARNT2

1.81e-052542MM14846
PathwayREACTOME_ENDOGENOUS_STEROLS

ARNT ARNT2

1.81e-052542M11184
PathwayREACTOME_ENDOGENOUS_STEROLS

ARNT ARNT2

2.11e-052742MM14844
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

ARNT ARNT2

3.38e-053442M39771
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

ARNT ARNT2

3.38e-053442M46422
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

ARNT ARNT2

1.21e-046442M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

ARNT ARNT2

1.29e-046642MM14839
PathwayKEGG_RENAL_CELL_CARCINOMA

ARNT ARNT2

1.45e-047042M13266
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

ARNT ARNT2

3.20e-0410442M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

ARNT ARNT2

3.27e-0410542MM14842
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

ARNT ARNT2

4.12e-0411842M27316
PathwayWP_CIRCADIAN_RHYTHM_GENES

ARNT ARNT2

1.19e-0320142M39605
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

ARNT ARNT2

1.41e-0321942MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

ARNT ARNT2

1.42e-0322042M10320
PathwayKEGG_PATHWAYS_IN_CANCER

ARNT ARNT2

3.08e-0332542M12868
PathwayWP_CANCER_PATHWAYS

ARNT ARNT2

7.38e-0350742M48302
PathwayREACTOME_METABOLISM_OF_LIPIDS

ARNT ARNT2

1.61e-0275742M27451
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ARNT ARNT2

1.65e-0276842MM14851
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ARNT ARNT2

2.85e-02102242MM15436
Pubmed

Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.

ARNT ARNT2

1.65e-0825217023418
Pubmed

Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.

ARNT ARNT2

1.65e-0825215466261
Pubmed

Expression of Arnt and Arnt2 mRNA in developing murine tissues.

ARNT ARNT2

4.96e-0835212502753
Pubmed

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.

ARNT ARNT2

4.96e-0835236343253
Pubmed

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).

ARNT ARNT2

4.96e-083528657146
Pubmed

Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.

ARNT ARNT2

4.96e-0835218096572
Pubmed

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

ARNT ARNT2

1.65e-075529545558
Pubmed

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development.

ARNT ARNT2

2.48e-0765211025203
Pubmed

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.

ARNT ARNT2

2.48e-076528927054
Pubmed

Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.

ARNT ARNT2

2.48e-0765217826745
Pubmed

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

ARNT ARNT2

3.47e-0775227782878
Pubmed

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.

ARNT ARNT2

3.47e-0775214701734
Pubmed

MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

ARNT ARNT2

3.47e-0775227472814
Pubmed

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.

ARNT ARNT2

4.63e-0785211782478
Pubmed

HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature.

ARNT ARNT2

7.44e-07105216824955
Pubmed

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.

ARNT ARNT2

9.09e-07115211381139
Pubmed

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

ARNT ARNT2

3.14e-06205220495570
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

ARNT ARNT2

3.53e-05665223275444
Pubmed

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.

ARNT ARNT2

7.82e-05985218557763
Pubmed

Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.

NTNG2 ARNT2

1.29e-041265216284245
InteractionNPAS4 interactions

ARNT ARNT2

4.43e-07642int:NPAS4
InteractionSIM1 interactions

ARNT ARNT2

8.27e-07842int:SIM1
InteractionNPAS3 interactions

ARNT ARNT2

1.06e-06942int:NPAS3
InteractionNR6A1 interactions

ARNT ARNT2

8.14e-062442int:NR6A1
InteractionSIM2 interactions

ARNT ARNT2

8.85e-062542int:SIM2
InteractionNPAS2 interactions

ARNT ARNT2

2.54e-054242int:NPAS2
InteractionTFEB interactions

ARNT ARNT2

3.91e-055242int:TFEB
InteractionLDB2 interactions

ARNT ARNT2

4.53e-055642int:LDB2
InteractionNR4A3 interactions

ARNT ARNT2

6.90e-056942int:NR4A3
InteractionTFAP2D interactions

ARNT ARNT2

1.15e-048942int:TFAP2D
InteractionARNT2 interactions

ARNT ARNT2

1.51e-0410242int:ARNT2
InteractionAHR interactions

ARNT ARNT2

2.53e-0413242int:AHR
InteractionTACC3 interactions

ARNT ARNT2

3.18e-0414842int:TACC3
InteractionTCF12 interactions

ARNT ARNT2

3.18e-0414842int:TCF12
InteractionEPAS1 interactions

ARNT ARNT2

4.35e-0417342int:EPAS1
InteractionTEAD1 interactions

ARNT ARNT2

4.50e-0417642int:TEAD1
InteractionCALML3 interactions

ARNT ARNT2

7.66e-0423042int:CALML3
InteractionNPAS1 interactions

ARNT ARNT2

8.69e-0424542int:NPAS1
InteractionARNT interactions

ARNT ARNT2

9.41e-0425542int:ARNT
InteractionTCF7L2 interactions

ARNT ARNT2

1.17e-0328542int:TCF7L2
InteractionNCOR1 interactions

ARNT ARNT2

1.90e-0336342int:NCOR1
InteractionSIN3A interactions

ARNT ARNT2

2.07e-0338042int:SIN3A
InteractionWWTR1 interactions

ARNT ARNT2

2.55e-0342242int:WWTR1
InteractionABT1 interactions

ARNT ARNT2

2.56e-0342342int:ABT1
InteractionHIF1A interactions

ARNT ARNT2

2.78e-0344142int:HIF1A
InteractionNDN interactions

ARNT ARNT2

2.94e-0345342int:NDN
InteractionCREBBP interactions

ARNT ARNT2

5.09e-0359942int:CREBBP
InteractionTRIM37 interactions

NTNG2 ARNT2

5.61e-0363042int:TRIM37
GeneFamilyBasic helix-loop-helix proteins

ARNT ARNT2

3.62e-0411052420
CoexpressionGSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN

ARNT NTNG2

5.15e-0419052M8457
CoexpressionGSE11864_UNTREATED_VS_CSF1_PAM3CYS_IN_MAC_UP

NTNG2 SLC46A2

5.59e-0419852M3129
CoexpressionGSE36527_CD62L_HIGH_VS_CD62L_LOW_TREG_CD69_NEG_KLRG1_NEG_UP

ARNT SLC46A2

5.71e-0420052M9023
CoexpressionKYNG_DNA_DAMAGE_UP

ARNT ARNT2

5.99e-0420552M3961
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTNG2 ARNT2 ABCA10

5.09e-071685317d46f993dc4ae22b8087808582aba77f5c61892
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

SLC46A2 ARNT2

8.11e-0512952b0c3cbab552e1d540e6b03a691dd245f81715e0b
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ARNT2 ABCA10

8.75e-05134523b67c02b430b6d58467f36e606c478d3eea0063f
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARNT NTNG2

1.20e-0415752c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCellAT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

SLC46A2 ARNT2

1.67e-04185523b3268e3f99121124e33086cac88479808d31630
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARNT2 ABCA10

1.72e-0418852eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARNT2 ABCA10

1.72e-0418852bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

ARNT2 ABCA10

1.72e-0418852df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARNT2 ABCA10

1.74e-0418952975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARNT2 ABCA10

1.74e-0418952977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARNT2 ABCA10

1.76e-0419052e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCelltumor_Lung-Epithelial_cells-tS1|tumor_Lung / Location, Cell class and cell subclass

SLC46A2 ARNT2

1.89e-04197528336e6647604e4bdd1596ea554c22203d13782e9
ToppCelltumor_Lung-Epithelial_cells-tS1|Epithelial_cells / Location, Cell class and cell subclass

SLC46A2 ARNT2

1.89e-04197527190143468939cf26c069d125a5e88e4bf026299
Drug11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol

ARNT ARNT2

1.39e-06952ctd:C541120
Drug2-acetamidoacrylate

ARNT ARNT2

2.12e-061152CID000079482
Drug1,3-dinitropyrene

ARNT ARNT2

4.05e-061552CID000053230
Drug2-nitrofluoranthene

ARNT ARNT2

5.89e-061852CID000025760
DrugHAHs

ARNT ARNT2

6.59e-061952CID003035605
Drug6-nitrochrysene

ARNT ARNT2

8.90e-062252CID000024121
Drughexachlorodibenzo-p-dioxin

ARNT ARNT2

1.06e-052452CID000038251
Drug1-aminopyrene

ARNT ARNT2

1.16e-052552CID000015352
Drug3-nitrofluoranthene

ARNT ARNT2

1.25e-052652CID000013462
DrugPeCDD

ARNT ARNT2

1.35e-052752CID000038439
DrugMCDF

ARNT ARNT2

1.46e-052852CID000114900
DrugAGN 193109

ARNT ARNT2

1.79e-053152CID000177238
DrugTCDF

ARNT ARNT2

2.16e-053452CID000039929
Drugp-dioxin

ARNT ARNT2

2.56e-053752CID000078968
DrugAC1L3U0V

ARNT ARNT2

3.00e-054052CID000122124
Drug2d3z

ARNT ARNT2

3.15e-054152CID009543495
Drugtirapazamine

ARNT ARNT2

3.98e-054652CID000033776
DrugRI-331

ARNT ARNT2

4.15e-054752CID000160754
DrugDB04724

ARNT ARNT2

4.33e-054852CID005288688
Drugbis(hexamethylene)triamine

ARNT ARNT2

5.91e-055652CID000008924
Drugdibenzofurans

ARNT ARNT2

8.23e-056652CID000000568
DrugDMEs

ARNT ARNT2

9.53e-057152CID003038361
DrugCoCl2

ARNT ARNT2

1.06e-047552CID003015678
Drug3'-dCTP

ARNT ARNT2

1.53e-049052CID000153054
DrugAC1L9FY1

ARNT ARNT2

1.93e-0410152CID000444218
Drugbutylbenzyl phthalate

ARNT ARNT2

2.21e-0410852ctd:C027561
Drugalpha-naphthoflavone

ARNT ARNT2

2.64e-0411852CID000011790
DrugTBHQ

ARNT ARNT2

3.76e-0414152CID000016043
Drugcobalt(II) chloride

ARNT ARNT2

4.03e-0414652CID000024288
Drugmepyramine

ARNT ARNT2

4.49e-0415452CID000004992
DrugNSC-683864

ARNT ARNT2

5.27e-0416752CID000148191
Drugm189

ARNT ARNT2

5.98e-0417852CID000022230
DrugAC1NDZBW

ARNT ARNT2

6.60e-0418752CID004634040
Drugsulforaphane

ARNT ARNT2

6.74e-0418952CID000005350
Drugpropofol

ARNT ARNT2

6.89e-0419152CID000004943
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; PC3; HT_HG-U133A

ARNT ARNT2

7.32e-04197524654_UP
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Up 200; 21uM; PC3; HT_HG-U133A

ARNT ARNT2

7.32e-04197524078_UP
Drug1,1-dimethylbiguanide hydrochloride; Down 200; 1000uM; MCF7; HG-U133A

ARNT ARNT2

7.47e-04199524_DN
Drugbeta-naphthoflavone

ARNT ARNT2

7.55e-0420052CID000002361
DrugAR E

ARNT ARNT2

9.96e-0423052CID004369394
Drug3-methylcholanthrene

ARNT ARNT2

1.00e-0323152CID000001674
Drugcyanide

ARNT ARNT2

1.21e-0325452CID000000768
Drugchromium

ARNT ARNT2

2.15e-0333952CID000023976
Drugdeferoxamine

ARNT ARNT2

2.20e-0334352CID000002973
Drugdioxin

ARNT ARNT2

2.25e-0334752CID000015625
Drugarsenite

ARNT ARNT2

2.25e-0334752CID000000544
Drugbenzo(a)pyrene

ARNT ARNT2

2.39e-0335852CID000002336
Drugcobalt-60

ARNT ARNT2

2.83e-0339052CID000061492
Drugo,p'-DDT

ARNT ARNT2

3.76e-0345152ctd:C016340
Drugafimoxifene

ARNT ARNT2

4.23e-0347952ctd:C016601
DrugNSC-364372

ARNT ARNT2

4.32e-0348452CID000435143
Drugoxygen

ARNT ARNT2

4.59e-0349952CID000000977
DiseaseHDL cholesterol change measurement

NTNG2 ABCA10

6.33e-062452EFO_0007805
DiseaseColorectal Neoplasms

ARNT ABCA10

8.62e-0427752C0009404
Diseasecorneal resistance factor

ARNT2 ABCA10

2.26e-0345152EFO_0010067
DiseaseColorectal Carcinoma

ARNT ABCA10

5.39e-0370252C0009402
Diseasetestosterone measurement

ARNT NTNG2

1.71e-02127552EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
SSMRMCMGSRRSFIC

ARNT

251

P27540
VCDRMAMMVSGTLRC

ABCA10

1406

Q8WWZ4
SMRMCMGSRRSFICR

ARNT2

226

Q9HBZ2
CMEAFGMSARRARDM

NTNG2

171

Q96CW9
FSRCFRDTTMIMIGM

SLC46A2

341

Q9BY10