Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD9	2.72e-04	8	66	2	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD9	4.35e-04	10	66	2	GO:0071141
GeneOntologyCellularComponent	inner dynein arm	DNAH10 DNAH7	4.35e-04	10	66	2	GO:0036156
Domain	Dwarfin	SMAD1 SMAD9	3.19e-04	8	64	2	IPR013790
Domain	DWB	SMAD1 SMAD9	3.19e-04	8	64	2	SM00524
Domain	MH2	SMAD1 SMAD9	3.19e-04	8	64	2	PS51076
Domain	MH1	SMAD1 SMAD9	3.19e-04	8	64	2	PS51075
Domain	-	SMAD1 SMAD9	3.19e-04	8	64	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD9	3.19e-04	8	64	2	IPR013019
Domain	MH2	SMAD1 SMAD9	3.19e-04	8	64	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD9	3.19e-04	8	64	2	IPR001132
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD9	7.46e-04	12	64	2	IPR003619
Domain	DWA	SMAD1 SMAD9	7.46e-04	12	64	2	SM00523
Domain	MH1	SMAD1 SMAD9	7.46e-04	12	64	2	PF03165
Domain	ELM2	TRERF1 MIDEAS	8.80e-04	13	64	2	PF01448
Domain	ELM2	TRERF1 MIDEAS	8.80e-04	13	64	2	PS51156
Domain	ELM2_dom	TRERF1 MIDEAS	8.80e-04	13	64	2	IPR000949
Domain	ELM2	TRERF1 MIDEAS	8.80e-04	13	64	2	SM01189
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH7	1.02e-03	14	64	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH7	1.02e-03	14	64	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH7	1.02e-03	14	64	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH7	1.02e-03	14	64	2	PF08393
Domain	IMPORTIN_B_NT	IPO5 IPO13	1.02e-03	14	64	2	PS50166
Domain	MT	DNAH10 DNAH7	1.02e-03	14	64	2	PF12777
Domain	AAA_8	DNAH10 DNAH7	1.02e-03	14	64	2	PF12780
Domain	HEAT	IPO5 IPO13 RANBP6	1.04e-03	58	64	3	IPR000357
Domain	DHC_fam	DNAH10 DNAH7	1.18e-03	15	64	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH7	1.18e-03	15	64	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH7	1.18e-03	15	64	2	PF03028
Domain	SMAD_dom-like	SMAD1 SMAD9	1.34e-03	16	64	2	IPR017855
Domain	-	SMAD1 SMAD9	1.34e-03	16	64	2	2.60.200.10
Domain	Importin-beta_N	IPO5 IPO13	1.52e-03	17	64	2	IPR001494
Domain	HEAT_REPEAT	IPO5 IPO13 RANBP6	1.78e-03	70	64	3	PS50077
Domain	SANT_dom	TRERF1 MIDEAS	3.56e-03	26	64	2	IPR017884
Domain	HECT	HACE1 HERC1	3.84e-03	27	64	2	PF00632
Domain	HECTc	HACE1 HERC1	3.84e-03	27	64	2	SM00119
Domain	HECT_dom	HACE1 HERC1	3.84e-03	27	64	2	IPR000569
Domain	HECT	HACE1 HERC1	3.84e-03	27	64	2	PS50237
Domain	SANT	TRERF1 MIDEAS	4.13e-03	28	64	2	PS51293
Domain	ARM-type_fold	IPO5 RALGAPA1 RTTN IPO13 RANBP6	6.08e-03	339	64	5	IPR016024
Domain	Myb_DNA-binding	TRERF1 MIDEAS	6.39e-03	35	64	2	PF00249
Pathway	KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY	SMAD1 SMAD9	2.07e-04	7	45	2	M47845
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	FASN ACLY SLC27A3	2.19e-04	37	45	3	M729
Pathway	REACTOME_FATTY_ACID_METABOLISM	FASN DPEP2 ACLY CYP2U1 SLC27A3	2.34e-04	176	45	5	M27854
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	FASN ACLY	2.76e-04	8	45	2	M26991
Pathway	KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY	SMAD1 SMAD9	2.76e-04	8	45	2	M47847
Pathway	KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY	SMAD1 SMAD9	3.54e-04	9	45	2	M47844
Pathway	KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY	SMAD1 SMAD9	3.54e-04	9	45	2	M47822
Pathway	PID_ALK2_PATHWAY	SMAD1 SMAD9	5.38e-04	11	45	2	M203
Pathway	KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY	SMAD1 SMAD9	5.38e-04	11	45	2	M47848
Pathway	WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION	SMAD1 SMAD9	7.60e-04	13	45	2	M39378
Pathway	WP_10Q1121Q1123_COPY_NUMBER_VARIATION_SYNDROME	ERCC5 SMAD1 SMAD9	9.61e-04	61	45	3	M48077
Pathway	WP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC	ACLY OGDH	1.16e-03	16	45	2	M39489
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN PLOD3 SHANK2 DOK4 CDK12 CASKIN1 AOC2 RTTN OSBPL5 TIGD3 HERC1 MFSD12	1.19e-06	1105	67	12	35748872
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	IPO5 FASN PLOD3 ACLY LARP1 OGDH	1.45e-06	182	67	6	31067453
Pubmed	Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate.	FAM20B SMAD1 SMAD9	1.48e-06	12	67	3	37298583
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	IPO5 GTF3C2 SMAD1 SMAD9	2.30e-06	48	67	4	27703004
Pubmed	meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes.	SHANK2 HACE1	3.66e-06	2	67	2	32616021
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 GTF3C2 CDK12 CASKIN1 FAM20B OSBPL5 IPO13 LARP1	8.07e-06	529	67	8	14621295
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD9	1.10e-05	3	67	2	31127639
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD9	1.10e-05	3	67	2	22897816
Pubmed	Amplification of USP13 drives ovarian cancer metabolism.	ACLY OGDH	1.10e-05	3	67	2	27892457
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD9	1.10e-05	3	67	2	30953749
Pubmed	The lipogenesis pathway as a cancer target.	FASN ACLY	1.10e-05	3	67	2	21726077
Pubmed	BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions.	FASN ACLY	1.10e-05	3	67	2	37801083
Pubmed	Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.	ACLY OGDH	1.10e-05	3	67	2	27582470
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD9	1.10e-05	3	67	2	21381028
Pubmed	Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin.	FASN ACLY	1.10e-05	3	67	2	21281598
Pubmed	MADR1, a MAD-related protein that functions in BMP2 signaling pathways.	SMAD1 SMAD9	1.10e-05	3	67	2	8653785
Pubmed	BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.	FASN ACLY	1.10e-05	3	67	2	37377173
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD9	1.10e-05	3	67	2	24023003
Pubmed	Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.	SHANK2 CASKIN1	1.10e-05	3	67	2	31727973
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD9	1.10e-05	3	67	2	27848974
Pubmed	KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.	SMAD1 SMAD9	2.19e-05	4	67	2	25536014
Pubmed	Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.	SMAD1 SMAD9	2.19e-05	4	67	2	28401685
Pubmed	A crucial role of a high mobility group protein HMGA2 in cardiogenesis.	SMAD1 SMAD9	2.19e-05	4	67	2	18425117
Pubmed	Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.	SMAD1 SMAD9	2.19e-05	4	67	2	23993924
Pubmed	Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.	SMAD1 SMAD9	2.19e-05	4	67	2	19244313
Pubmed	Signal transduction of bone morphogenetic protein receptors.	SMAD1 SMAD9	2.19e-05	4	67	2	14687659
Pubmed	Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.	SMAD1 SMAD9	2.19e-05	4	67	2	17967875
Pubmed	Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.	SMAD1 SMAD9	2.19e-05	4	67	2	25755279
Pubmed	Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.	SMAD1 SMAD9	2.19e-05	4	67	2	34719843
Pubmed	Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.	SMAD1 SMAD9	2.19e-05	4	67	2	22452883
Pubmed	Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.	FASN ACLY OGDH	2.67e-05	30	67	3	31693883
Pubmed	Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.	SMAD1 SMAD9	3.64e-05	5	67	2	27188281
Pubmed	The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.	SMAD1 SMAD9	3.64e-05	5	67	2	21246655
Pubmed	Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.	SMAD1 SMAD9	3.64e-05	5	67	2	18775991
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	FASN ACLY	3.64e-05	5	67	2	37163372
Pubmed	Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.	SMAD1 SMAD9	3.64e-05	5	67	2	26735394
Pubmed	Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.	SMAD1 SMAD9	3.64e-05	5	67	2	38703029
Pubmed	FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.	SMAD1 SMAD9	3.64e-05	5	67	2	23559326
Pubmed	Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.	SMAD1 SMAD9	3.64e-05	5	67	2	15743817
Pubmed	Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.	SMAD1 SMAD9	3.64e-05	5	67	2	11121043
Pubmed	Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.	SMAD1 SMAD9	3.64e-05	5	67	2	20651281
Pubmed	Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation.	SMAD1 SMAD9	3.64e-05	5	67	2	19918795
Pubmed	Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals.	SMAD1 SMAD9	3.64e-05	5	67	2	38175868
Pubmed	Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.	SMAD1 SMAD9	3.64e-05	5	67	2	10583507
Pubmed	B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling.	SMAD1 SMAD9	3.64e-05	5	67	2	15542835
Pubmed	The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.	SMAD1 SMAD9	3.64e-05	5	67	2	33393086
Pubmed	Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.	SMAD1 SMAD9	3.64e-05	5	67	2	38300806
Pubmed	Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.	SMAD1 SMAD9	3.64e-05	5	67	2	16813523
Pubmed	PEG3 controls lipogenesis through ACLY.	FASN ACLY	3.64e-05	5	67	2	34048454
Pubmed	Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.	SMAD1 SMAD9	3.64e-05	5	67	2	25141865
Pubmed	The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta.	SMAD1 SMAD9	3.64e-05	5	67	2	29253505
Pubmed	Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.	SMAD1 SMAD9	3.64e-05	5	67	2	27612439
Pubmed	Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.	SMAD1 SMAD9	3.64e-05	5	67	2	27890611
Pubmed	Requirement of Oct3/4 function for germ cell specification.	SMAD1 SMAD9	3.64e-05	5	67	2	18395706
Pubmed	The dynamic interactome of human Aha1 upon Y223 phosphorylation.	FASN GTF3C2 ACLY AGL	3.66e-05	96	67	4	26693507
Pubmed	The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.	FASN ACLY SLC27A3	5.07e-05	37	67	3	35863637
Pubmed	Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans.	LIG1 ERCC5	5.46e-05	6	67	2	18709642
Pubmed	Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development.	SMAD1 SMAD9	5.46e-05	6	67	2	20522595
Pubmed	Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.	SMAD1 SMAD9	5.46e-05	6	67	2	9256479
Pubmed	Quantitative analysis of signaling responses during mouse primordial germ cell specification.	SMAD1 SMAD9	5.46e-05	6	67	2	34184730
Pubmed	Smad7 is required for the development and function of the heart.	SMAD1 SMAD9	5.46e-05	6	67	2	18952608
Pubmed	Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.	SMAD1 SMAD9	5.46e-05	6	67	2	21518886
Pubmed	Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.	SMAD1 SMAD9	5.46e-05	6	67	2	27250101
Pubmed	ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.	SMAD1 SMAD9	5.46e-05	6	67	2	20042635
Pubmed	PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling.	SMAD1 SMAD9	5.46e-05	6	67	2	25470749
Pubmed	BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.	SMAD1 SMAD9	5.46e-05	6	67	2	33436697
Pubmed	BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst.	SMAD1 SMAD9	5.46e-05	6	67	2	20837004
Pubmed	Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.	SMAD1 SMAD9	5.46e-05	6	67	2	11850197
Pubmed	Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade.	SMAD1 SMAD9	5.46e-05	6	67	2	15188429
Pubmed	Lack of the bone morphogenetic protein BMP6 induces massive iron overload.	SMAD1 SMAD9	5.46e-05	6	67	2	19252488
Pubmed	BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.	SMAD1 SMAD9	5.46e-05	6	67	2	28576771
Pubmed	BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells.	SMAD1 SMAD9	5.46e-05	6	67	2	19269967
Pubmed	SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.	SMAD1 SMAD9	5.46e-05	6	67	2	18069690
Pubmed	The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification.	SMAD1 SMAD9	5.46e-05	6	67	2	22723422
Pubmed	Development of bat flight: morphologic and molecular evolution of bat wing digits.	SMAD1 SMAD9	5.46e-05	6	67	2	16618938
Pubmed	Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.	SMAD1 SMAD9	7.63e-05	7	67	2	15376321
Pubmed	BMPER-induced BMP signaling promotes coronary artery remodeling.	SMAD1 SMAD9	7.63e-05	7	67	2	24373957
Pubmed	Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.	SMAD1 SMAD9	7.63e-05	7	67	2	15009097
Pubmed	Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.	SMAD1 SMAD9	7.63e-05	7	67	2	20807528
Pubmed	Emergence of dorsal-ventral polarity in ESC-derived retinal tissue.	SMAD1 SMAD9	7.63e-05	7	67	2	27633992
Pubmed	Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.	SMAD1 SMAD9	7.63e-05	7	67	2	18322278
Pubmed	Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis.	SMAD1 SMAD9	7.63e-05	7	67	2	19782070
Pubmed	Noggin is required for early development of murine upper incisors.	SMAD1 SMAD9	7.63e-05	7	67	2	22302143
Pubmed	Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13.	IPO5 IPO13	7.63e-05	7	67	2	15964792
Pubmed	Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge.	SMAD1 SMAD9	7.63e-05	7	67	2	18003744
Pubmed	Negative regulation of BMP/Smad signaling by Tob in osteoblasts.	SMAD1 SMAD9	7.63e-05	7	67	2	11163184
Pubmed	Role of smad- and wnt-dependent pathways in embryonic cardiac development.	SMAD1 SMAD9	7.63e-05	7	67	2	16522160
Pubmed	Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.	SMAD1 SMAD9	7.63e-05	7	67	2	25758226
Pubmed	Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2.	SMAD1 SMAD9	7.63e-05	7	67	2	23680673
Pubmed	Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.	SMAD1 SMAD9	7.63e-05	7	67	2	19116164
Pubmed	Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.	SMAD1 SMAD9	7.63e-05	7	67	2	29151265
Pubmed	Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.	SMAD1 SMAD9	7.63e-05	7	67	2	16624858
Pubmed	HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.	SMAD1 SMAD9	7.63e-05	7	67	2	24269886
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	IPO5 LIG1 AAMP FASN PDE4D GLRX3 ACLY AGL LARP1 RANBP6 HERC1	9.85e-05	1455	67	11	22863883
Pubmed	A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.	SMAD1 SMAD9	1.02e-04	8	67	2	19211612
Pubmed	Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.	SMAD1 SMAD9	1.02e-04	8	67	2	10647776
Pubmed	Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.	SMAD1 SMAD9	1.02e-04	8	67	2	29126155
Pubmed	SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.	SMAD1 SMAD9	1.02e-04	8	67	2	30446626
Pubmed	Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation.	SMAD1 SMAD9	1.02e-04	8	67	2	36116371
Pubmed	Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.	IPO5 IPO13	1.02e-04	8	67	2	36690276
GeneFamily	SMAD family	SMAD1 SMAD9	1.46e-04	8	42	2	750
GeneFamily	Dyneins, axonemal	DNAH10 DNAH7	7.01e-04	17	42	2	536
GeneFamily	Armadillo repeat containing\|Importins	IPO5 IPO13	7.87e-04	18	42	2	596
GeneFamily	Ankyrin repeat domain containing	SHANK2 CASKIN1 ANKEF1 HACE1	2.35e-03	242	42	4	403
GeneFamily	Cyclins\|F-boxes other	FBH1 FBXO42	3.70e-03	39	42	2	560
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	TRERF1 MIDEAS	6.73e-03	53	42	2	532
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERCC5 OSBPL5 RANBP6 NEB FANCM DTHD1	2.35e-07	172	67	6	f3c16a62eba1ed190318beee131c71c5150b266a
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 NME5 DTHD1 BAIAP3 DNAH7	8.98e-06	186	67	5	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	multiciliated\|World / shred by cell class for bronchial biopsy	DNAH10 NME5 DTHD1 BAIAP3 DNAH7	9.45e-06	188	67	5	6833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 BAIAP3 DNAH7	9.70e-06	189	67	5	b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	SHANK2 DNAH10 NME5 DTHD1 DNAH7	1.05e-05	192	67	5	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 BAIAP3 DNAH7	1.07e-05	193	67	5	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	SHANK2 DNAH10 NME5 DTHD1 DNAH7	1.10e-05	194	67	5	958e648138676d46698090b4046cb484083ae449
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	PDE4D SHANK2 DNAH10 DTHD1 DNAH7	1.13e-05	195	67	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	PDE4D SHANK2 DNAH10 DTHD1 DNAH7	1.13e-05	195	67	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 ANKEF1 DTHD1 DNAH7	8.56e-05	154	67	4	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 ANKEF1 DTHD1 DNAH7	8.56e-05	154	67	4	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 ANKEF1 DTHD1 DNAH7	8.77e-05	155	67	4	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 ANKEF1 DTHD1 DNAH7	8.77e-05	155	67	4	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 DPEP2 DTHD1 TLR8	9.68e-05	159	67	4	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY75 CYB561A3 GRM8 SLC27A3	9.92e-05	160	67	4	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-B\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PLOD3 DPEP2 LY75 CYB561A3	9.92e-05	160	67	4	694bf1f1952bd8ab444819f533da24fa2b73f701
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIG1 DPEP2 RTTN LY75	1.20e-04	168	67	4	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYT16 DNAH10 DTHD1 DNAH7	1.22e-04	169	67	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRERF1 LIG1 DOK4 CASKIN1	1.22e-04	169	67	4	f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DTHD1 BAIAP3 DNAH7	1.22e-04	169	67	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHANK2 DNAH10 CASKIN1 BAIAP3	1.46e-04	177	67	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	Ciliated_cells-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.53e-04	179	67	4	0e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DTHD1 BAIAP3 DNAH7	1.53e-04	179	67	4	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DTHD1 BAIAP3 DNAH7	1.56e-04	180	67	4	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	DNAH10 DTHD1 BAIAP3 DNAH7	1.63e-04	182	67	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.63e-04	182	67	4	f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.63e-04	182	67	4	975f6275777fc578eba528e50f69891c66ec44ad
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.70e-04	184	67	4	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	DNAH10 DTHD1 BAIAP3 DNAH7	1.73e-04	185	67	4	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	Ciliated_cells-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	NME5 DTHD1 BAIAP3 DNAH7	1.73e-04	185	67	4	4fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SHANK2 DNAH10 BAIAP3 DNAH7	1.73e-04	185	67	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Ciliated_cells-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 NME5 DTHD1 DNAH7	1.77e-04	186	67	4	f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 DTHD1 BAIAP3 DNAH7	1.77e-04	186	67	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	Ciliated_cells-B-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.81e-04	187	67	4	2b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DNAH10 NME5 DTHD1 DNAH7	1.81e-04	187	67	4	9e10ed56090d82589bc457788282f664b70ace4b
ToppCell	21-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	1.81e-04	187	67	4	1a2178a195d078d1963947b327c6d0d4f2f48341
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	1.81e-04	187	67	4	e61992de4f98eeea08b43213850769d923f8db48
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.84e-04	188	67	4	da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCell	COPD-Lymphoid-NK\|COPD / Disease state, Lineage and Cell class	TRERF1 PDE4D OSBPL5 DTHD1	1.84e-04	188	67	4	c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCell	21-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	1.84e-04	188	67	4	803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCell	367C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.84e-04	188	67	4	82c006f43c93f4a867953a446864f02b44536a23
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.88e-04	189	67	4	57ab947b81dbd9d3e896be89e28c4a62cf720837
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH10 NME5 DTHD1 DNAH7	1.88e-04	189	67	4	ebc16b8eab84167d74446783d7e802acedc6b9c6
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DNAH10 NME5 DTHD1 DNAH7	1.88e-04	189	67	4	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	Multiciliated\|World / shred by cell class for nasal brushing	DNAH10 DTHD1 BAIAP3 DNAH7	1.88e-04	189	67	4	34b110aef839376228c5a403a6b5047a945f472b
ToppCell	Control-Epithelial-Ciliated\|Control / Disease state, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	1.88e-04	189	67	4	c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCell	Ciliated\|World / shred by cell class for parenchyma	DNAH10 NME5 DTHD1 DNAH7	1.88e-04	189	67	4	711181ca3b9102fb155168b646b0a9b09ff215b2
ToppCell	Ciliated_cells-A\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.92e-04	190	67	4	cd87731aaa7d252424f79cfce9f7931457f17bdf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 PDE4D IMMP2L GRM8	1.92e-04	190	67	4	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DNAH10 NME5 DTHD1 DNAH7	1.92e-04	190	67	4	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	Epithelial_cells-Ciliated_cells-A\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.92e-04	190	67	4	549d813a8f23b175875e53347928941f143e236c
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DNAH10 NME5 DTHD1 DNAH7	1.92e-04	190	67	4	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	Ciliated_cells-B\|World / lung cells shred on cell class, cell subclass, sample id	DNAH10 DTHD1 BAIAP3 DNAH7	1.92e-04	190	67	4	7031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCell	Healthy_Control-Epithelial-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	DNAH10 NME5 DTHD1 C16orf89	1.96e-04	191	67	4	15b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 BAIAP3 DNAH7	1.96e-04	191	67	4	683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	DNAH10 NME5 BAIAP3 DNAH7	1.96e-04	191	67	4	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	Healthy_Control-Epithelial-Epithelial-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	DNAH10 NME5 DTHD1 C16orf89	1.96e-04	191	67	4	28caedb2e448e0c7f494100d714fa7cdcf150691
ToppCell	Healthy_Control-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	DNAH10 NME5 DTHD1 C16orf89	1.96e-04	191	67	4	fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	DNAH10 NME5 BAIAP3 DNAH7	1.96e-04	191	67	4	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	multiciliated\|World / shred by cell class for turbinate	DNAH10 NME5 DTHD1 DNAH7	2.00e-04	192	67	4	0f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	DNAH10 NME5 DTHD1 DNAH7	2.00e-04	192	67	4	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.00e-04	192	67	4	1b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	2.00e-04	192	67	4	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DNAH10 NME5 DTHD1 DNAH7	2.04e-04	193	67	4	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	Bronchial_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	DNAH10 NME5 DTHD1 DNAH7	2.04e-04	193	67	4	3e693ac4c92576e3f2c9efdd3f1d96d3d336e260
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FASN DOK4 SLC27A3 C16orf89	2.04e-04	193	67	4	ba484fa1f290a92ae02475a4c468b4ac840c133e
ToppCell	15-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	2.04e-04	193	67	4	aa3acc7571405169efb656d214f3a8cbf988362e
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRERF1 PDE4D OSBPL5 DTHD1	2.08e-04	194	67	4	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 PDE4D IMMP2L GRM8	2.08e-04	194	67	4	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 PDE4D IMMP2L GRM8	2.08e-04	194	67	4	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 IMMP2L GRM8 DNAH7	2.08e-04	194	67	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SHANK2 IMMP2L DNAH7	2.08e-04	194	67	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.08e-04	194	67	4	a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell	cellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	d8bf15aa7cdbc5f29b58e1e6cff76c257f0ea12e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	93b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SHANK2 IMMP2L DNAH7	2.12e-04	195	67	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DTHD1 BAIAP3 DNAH7	2.12e-04	195	67	4	79dc031258579ea328181dda33710dd897f1064a
ToppCell	NS-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	34e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	0e763f36786515698b593e5c93f6a56619c1242d
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SHANK2 DNAH10 DTHD1 DNAH7	2.12e-04	195	67	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	3e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 DTHD1 BAIAP3 DNAH7	2.12e-04	195	67	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 DTHD1 BAIAP3 DNAH7	2.12e-04	195	67	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	581b04220587e1d5198b1abd6965965ace7803e7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LIG1 MYO19 RTTN SLBP	2.12e-04	195	67	4	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	cellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH10 NME5 DTHD1 DNAH7	2.12e-04	195	67	4	e7f069f557a59ee7b502ff82ad4c9f47fa619ba8
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LIG1 MYO19 RTTN SLBP	2.12e-04	195	67	4	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	COVID-19-Epithelial-Ciliated_cells\|Epithelial / Condition, Lineage and Cell class	DNAH10 NME5 DTHD1 DNAH7	2.16e-04	196	67	4	de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 NME5 DTHD1 DNAH7	2.16e-04	196	67	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHANK2 DNAH10 DTHD1 DNAH7	2.20e-04	197	67	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH10 NME5 DTHD1 DNAH7	2.20e-04	197	67	4	e453d085182364ca347cbcc9dc995c62c3353016
Disease	primary ciliary dyskinesia (is_implicated_in)	NME5 DNAH7	6.48e-05	6	62	2	DOID:9562 (is_implicated_in)
Disease	Idiopathic pulmonary hypertension	SMAD1 SMAD9	1.55e-04	9	62	2	C0152171
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD9	3.34e-04	13	62	2	DOID:0050787 (implicated_via_orthology)
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	SMAD1 SMAD9	3.89e-04	14	62	2	C1150929
Disease	mean corpuscular hemoglobin concentration	CDK12 DPEP2 RTTN ASCC2 LARP1 NEB LY75 MIDEAS SMAD1	4.77e-04	1105	62	9	EFO_0004528
Disease	Idiopathic pulmonary arterial hypertension	SMAD1 SMAD9	5.11e-04	16	62	2	C3203102
Disease	Familial primary pulmonary hypertension	SMAD1 SMAD9	5.79e-04	17	62	2	C0340543
Disease	Tourette syndrome, schizophrenia	DNAH10 MYO19	6.50e-04	18	62	2	EFO_0004895, MONDO_0005090
Disease	hip circumference	RALGAPA1 FASN SHANK2 DNAH10 ANKEF1	7.26e-04	338	62	5	EFO_0005093
Disease	Autistic Disorder	SHANK2 CSMD3 IMMP2L GRM8	2.23e-03	261	62	4	C0004352
Disease	amino acid measurement	IPO5 LIG1 PDE4D LARP1 DNAH7 C16orf89	2.97e-03	678	62	6	EFO_0005134
Disease	myositis	PDE4D DOK4	3.06e-03	39	62	2	EFO_0000783
Disease	bipolar I disorder	SHANK2 MYO19 IMMP2L	3.29e-03	141	62	3	EFO_0009963
Disease	autistic disorder (is_implicated_in)	SHANK2 GRM8	3.54e-03	42	62	2	DOID:12849 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDLPHWQDCHELWSK	CDK12	1031	Q9NYV4
QPGFWKLPHAWIHTD	C16orf89	126	Q6UX73
EPLLCEKNHWWSHPL	CSMD3	1046	Q7Z407
DLEWMEWHPRAPVLL	AAMP	176	Q13685
HIQELWVRLAWPDPA	BAIAP3	746	O94812
LDWLLALPHDKFWCQ	ASCC2	66	Q9H1I8
PNPLWALRLHDWSVE	ANKEF1	321	Q9NU02
VWAARVNKHKPWLEP	CLSTN1	26	O94985
ATHILWPPERWQKLE	IMMP2L	146	Q96T52
LISLHPFNPWNWGKL	C8orf76	156	Q96K31
VFKPVAAPWNPEHWL	AOC2	541	O75106
LHPDLWQIFDNPVDW	PLOD3	526	O60568
PWAWQPLKVENEEHG	FBXO42	321	Q6P3S6
DWLPEHKPANLAVWL	CASKIN1	536	Q8WXD9
WQPEIKPEPAWHDQD	LARP1	306	Q6PKG0
LQWHLPEGAAFSWLP	MYO19	251	Q96H55
KSLLVVHFWAPWAPQ	GLRX3	31	O76003
LSLSEWRLWQDHPLP	FANCM	731	Q8IYD8
PPVKLKWLEHLNSSW	HERC1	6	Q15751
PLWETWADLVHPDAQ	PDE4D	681	Q08499
PADPLIWLADWLLKN	NME5	181	P56597
VFKPLELLWHSLDEW	HACE1	356	Q8IYU2
WSDHKPLNFLNWDPD	LY75	291	O60449
EVLPHWLSWLPLHED	IPO5	991	O00410
LIPIIKLEWHSPWAV	GRM8	571	O00222
EKILHIKHWLDSPWP	OGDH	576	Q02218
LWSVHRDPAIWEKPE	CYP2U1	446	Q7Z449
RPVIWWAPDVQHLSD	GASK1A	366	Q9UFP1
HLWREIISDPLFIPW	FBH1	241	Q8NFZ0
AQPPIELLRQWLDHW	DNAH7	2056	Q8WXX0
KDPVEALWDNLLHWL	DTHD1	671	Q6ZMT9
PHKADLVWQPWEDLE	MIDEAS	746	Q6PJG2
TEIPIHWTAKLPAKW	DPEP2	446	Q9H4A9
SWVGPKLPWKLLHAA	CYB561A3	71	Q8NBI2
SPLIKWDHSLAWDVP	FASN	831	P49327
IPDHWLDPSAVWEVK	LIG1	831	P18858
WVPWSKLVPEYIHAP	DNAH10	2406	Q8IVF4
PQAWHFSWQLLQPDK	IPO13	56	O94829
TAQPLLLWKHWLREP	MFSD12	261	Q6NUT3
LWDIHNPRVKLVSWP	DOK4	166	Q8TEW6
WKPQLFHLDPITQEW	OSBPL5	691	Q9H0X9
FLLGSQHKLLPWWLP	NUTM2D	691	Q5VT03
EAHLVPVLHSLWPWI	RTTN	1946	Q86VV8
LPFWTWLDKILELVH	STAT2	551	P52630
QIKLWKVALHFWDPP	SLBP	186	Q14493
SQWPNWASDDRKLPH	SYT16	121	Q17RD7
LPHEDLPFWLVRWLL	LMF2	161	Q9BU23
WLKLDNTIGPHWDLF	SEL1L2	656	Q5TEA6
LEPLLKFSEWWHEAQ	ERCC5	886	P28715
IWDVFLWDHVLPPKE	MPTX1	91	A8MV57
NVDEVLPHWLSWLPL	RANBP6	996	O60518
LPHWLSWLPLHEDKE	RANBP6	1001	O60518
WRWPDLQSHHELKPL	SMAD9	96	O15198
VWRWPDLQSHHELKP	SMAD1	91	Q15797
KPVHLWTKPDVADWL	SHANK2	1781	Q9UPX8
PDTDWARLLQDHPWL	ACLY	36	P53396
HPDLGIPWLEWLAQF	TIGD3	236	Q6B0B8
ILQWPDNPKAEGLFW	TLR8	1001	Q9NR97
IRWLVSFWLEPKPHT	RALGAPA1	306	Q6GYQ0
HLWPQLRWLPADLAF	SLC27A3	21	Q5K4L6
LWAVDKAGPAWIPHL	STPG3	366	Q8N7X2
VTLWLPDVWPLQKHR	FAM20B	221	O75063
FVQRHAPWKLNWESP	MARS2	486	Q96GW9
IPLAWKWHLLSELEA	GTF3C2	331	Q8WUA4
SLHPFNPWNWGKLAE	ZHX1-C8orf76	126	Q96EF9
KATLVWKPWPELENH	TRERF1	806	Q96PN7
WKPWPELENHDLQQR	TRERF1	811	Q96PN7
SPHLKPAWVLDRALW	AGL	241	P35573
AHWKWTPDRPDFLQA	NEB	5556	P20929