Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondisaccharide binding

LGALS9C LGALS9B LGALS9

2.22e-067813GO:0048030
GeneOntologyMolecularFunctiongalactoside binding

LGALS9C LGALS9B LGALS9

5.31e-069813GO:0016936
GeneOntologyMolecularFunctionoligosaccharide binding

LGALS9C LGALS9B LGALS9

6.97e-0520813GO:0070492
GeneOntologyBiologicalProcessnegative regulation of natural killer cell degranulation

LGALS9C LGALS9B LGALS9

2.24e-074803GO:0043322
GeneOntologyBiologicalProcessregulation of natural killer cell degranulation

LGALS9C LGALS9B LGALS9

3.10e-068803GO:0043321
GeneOntologyBiologicalProcesspositive regulation of regulatory T cell differentiation

LGALS9C LGALS9B CR1 LGALS9

6.10e-0631804GO:0045591
GeneOntologyBiologicalProcessnegative regulation of regulated secretory pathway

LGALS9C LGALS9B NOTCH1 LGALS9

6.95e-0632804GO:1903306
GeneOntologyBiologicalProcessT cell chemotaxis

LGALS9C LGALS9B PLEC LGALS9

7.88e-0633804GO:0010818
GeneOntologyBiologicalProcessnegative regulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

2.47e-0515803GO:2000562
GeneOntologyBiologicalProcessnegative regulation of natural killer cell activation

LGALS9C LGALS9B LGALS9

2.47e-0515803GO:0032815
GeneOntologyBiologicalProcessnegative regulation of exocytosis

LGALS9C LGALS9B NOTCH1 LGALS9

2.77e-0545804GO:0045920
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

LGALS9C LGALS9B MYPN PALLD PLXNB3 CDH17 CDHR4 LGALS9

2.89e-05313808GO:0098742
GeneOntologyBiologicalProcessnegative regulation of leukocyte degranulation

LGALS9C LGALS9B LGALS9

3.67e-0517803GO:0043301
GeneOntologyBiologicalProcessregulation of regulatory T cell differentiation

LGALS9C LGALS9B CR1 LGALS9

3.89e-0549804GO:0045589
GeneOntologyBiologicalProcessnatural killer cell degranulation

LGALS9C LGALS9B LGALS9

4.40e-0518803GO:0043320
GeneOntologyBiologicalProcesspositive regulation of activation of membrane attack complex

C6 CR1

4.45e-053802GO:0001970
GeneOntologyBiologicalProcessnegative regulation of type II interferon production

LGALS9C LGALS9B CR1 LGALS9

4.56e-0551804GO:0032689
GeneOntologyBiologicalProcessnegative regulation of cell killing

LGALS9C LGALS9B CR1 LGALS9

4.93e-0552804GO:0031342
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

5.21e-0519803GO:0046642
GeneOntologyBiologicalProcesspositive regulation of defense response to bacterium

LGALS9C LGALS9B LGALS9

5.21e-0519803GO:1900426
GeneOntologyBiologicalProcesslymphocyte chemotaxis

LGALS9C LGALS9B PLEC LGALS9

5.32e-0553804GO:0048247
GeneOntologyBiologicalProcessregulatory T cell differentiation

LGALS9C LGALS9B CR1 LGALS9

5.73e-0554804GO:0045066
GeneOntologyBiologicalProcessregulation of T cell chemotaxis

LGALS9C LGALS9B LGALS9

6.11e-0520803GO:0010819
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation

LGALS9C LGALS9B LGALS9

7.11e-0521803GO:0032823
GeneOntologyBiologicalProcesscell chemotaxis

LGALS9C CSF1 LGALS9B TRPM2 PLEC NOTCH1 PLXNB3 LGALS9

8.20e-05363808GO:0060326
GeneOntologyBiologicalProcesspositive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LGALS9C LGALS9B NOTCH1 RNF111 LGALS9

8.50e-05115805GO:0090100
GeneOntologyBiologicalProcessregulation of activation of membrane attack complex

C6 CR1

8.87e-054802GO:0001969
GeneOntologyBiologicalProcessT-helper 17 type immune response

LGALS9C LGALS9B NOTCH1 LGALS9

1.12e-0464804GO:0072538
GeneOntologyBiologicalProcesspositive regulation of cell development

LGALS9C LIMK1 CSF1 MEGF8 LGALS9B GJC2 CR1 NOTCH1 PLXNB3 LGALS9

1.28e-046148010GO:0010720
GeneOntologyBiologicalProcessregulation of defense response to bacterium

LGALS9C LGALS9B LGALS9

1.37e-0426803GO:1900424
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

1.72e-0428803GO:2000561
GeneOntologyBiologicalProcesschemotaxis

LGALS9C CSF1 MEGF8 LGALS9B TRPM2 PLEC NOTCH1 PLXNB3 LGALS9

1.74e-04517809GO:0006935
GeneOntologyBiologicalProcesstaxis

LGALS9C CSF1 MEGF8 LGALS9B TRPM2 PLEC NOTCH1 PLXNB3 LGALS9

1.79e-04519809GO:0042330
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

2.12e-0430803GO:0035739
GeneOntologyBiologicalProcessactivation of membrane attack complex

C6 CR1

2.21e-046802GO:0001905
GeneOntologyBiologicalProcessregulation of lymphocyte chemotaxis

LGALS9C LGALS9B LGALS9

2.34e-0431803GO:1901623
GeneOntologyBiologicalProcessT cell migration

LGALS9C LGALS9B PLEC LGALS9

2.78e-0481804GO:0072678
GeneOntologyBiologicalProcessnegative regulation of lymphocyte mediated immunity

LGALS9C LGALS9B CR1 LGALS9

3.06e-0483804GO:0002707
GeneOntologyBiologicalProcessregulation of somitogenesis

DMRT2 NOTCH1

3.08e-047802GO:0014807
GeneOntologyBiologicalProcessregulation of chemotaxis

LGALS9C CSF1 MEGF8 LGALS9B NOTCH1 LGALS9

3.57e-04242806GO:0050920
GeneOntologyBiologicalProcessregulation of T cell differentiation in thymus

LGALS9C LGALS9B LGALS9

3.97e-0437803GO:0033081
GeneOntologyBiologicalProcessnatural killer cell differentiation

LGALS9C LGALS9B LGALS9

4.30e-0438803GO:0001779
GeneOntologyBiologicalProcessnegative regulation of natural killer cell mediated cytotoxicity

LGALS9C LGALS9B LGALS9

5.01e-0440803GO:0045953
GeneOntologyBiologicalProcessnegative regulation of CD4-positive, alpha-beta T cell activation

LGALS9C LGALS9B LGALS9

5.01e-0440803GO:2000515
GeneOntologyBiologicalProcessmononuclear cell migration

LGALS9C CSF1 LGALS9B TRPM2 PLEC LGALS9

5.01e-04258806GO:0071674
GeneOntologyBiologicalProcesspositive regulation of complement activation

C6 CR1

5.25e-049802GO:0045917
GeneOntologyBiologicalProcessnegative regulation of leukocyte mediated immunity

LGALS9C LGALS9B CR1 LGALS9

5.32e-0496804GO:0002704
GeneOntologyBiologicalProcessnegative regulation of natural killer cell mediated immunity

LGALS9C LGALS9B LGALS9

5.39e-0441803GO:0002716
GeneOntologyBiologicalProcesspositive regulation of T cell migration

LGALS9C LGALS9B LGALS9

5.39e-0441803GO:2000406
GeneOntologyBiologicalProcessnatural killer cell activation involved in immune response

LGALS9C LGALS9B LGALS9

5.78e-0442803GO:0002323
GeneOntologyBiologicalProcesspositive regulation of macrophage activation

LGALS9C LGALS9B LGALS9

5.78e-0442803GO:0043032
GeneOntologyBiologicalProcessleukocyte chemotaxis

LGALS9C CSF1 LGALS9B TRPM2 PLEC LGALS9

6.00e-04267806GO:0030595
GeneOntologyBiologicalProcesspositive regulation of SMAD protein signal transduction

LGALS9C LGALS9B LGALS9

6.20e-0443803GO:0060391
GeneOntologyBiologicalProcesspositive regulation of mononuclear cell migration

LGALS9C CSF1 LGALS9B LGALS9

7.19e-04104804GO:0071677
GeneOntologyBiologicalProcesspositive regulation of oxidoreductase activity

LGALS9C LGALS9B LGALS9

7.56e-0446803GO:0051353
GeneOntologyBiologicalProcessnegative regulation of T cell proliferation

LGALS9C LGALS9B CR1 LGALS9

8.00e-04107804GO:0042130
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

MYPN PALLD PLXNB3 CDH17 CDHR4

8.05e-04187805GO:0007156
GeneOntologyBiologicalProcessnegative regulation of leukocyte mediated cytotoxicity

LGALS9C LGALS9B LGALS9

8.06e-0447803GO:0001911
GeneOntologyBiologicalProcessregulation of T-helper 17 type immune response

LGALS9C LGALS9B LGALS9

8.06e-0447803GO:2000316
GeneOntologyBiologicalProcesspositive regulation of interleukin-10 production

LGALS9C LGALS9B LGALS9

8.57e-0448803GO:0032733
GeneOntologyBiologicalProcesspositive regulation of lymphocyte migration

LGALS9C LGALS9B LGALS9

9.10e-0449803GO:2000403
GeneOntologyBiologicalProcesspositive regulation of intracellular estrogen receptor signaling pathway

KMT2D SRARP

9.56e-0412802GO:0033148
GeneOntologyBiologicalProcesscell-cell adhesion mediated by cadherin

ADAM19 NOTCH1 CDH17

9.66e-0450803GO:0044331
GeneOntologyBiologicalProcessnegative regulation of innate immune response

LGALS9C LGALS9B CR1 LGALS9

1.01e-03114804GO:0045824
GeneOntologyBiologicalProcesslymphocyte migration

LGALS9C LGALS9B PLEC LGALS9

1.08e-03116804GO:0072676
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell activation

LGALS9C LGALS9B LGALS9

1.08e-0352803GO:0046636
GeneOntologyBiologicalProcessregulation of alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

1.14e-0353803GO:0046640
MousePhenoabnormal brain wave pattern

PER2 TRPM2 SCN10A CHRM3 RAI1

6.52e-0664585MP:0004994
MousePhenoenhanced humoral immune response

LGALS9C LGALS9B LGALS9

4.42e-0517583MP:0020155
MousePhenoincreased T-helper 1 cell number

LGALS9C LGALS9B LGALS9

6.27e-0519583MP:0008086
MousePhenoincreased spleen germinal center size

LGALS9C LGALS9B LGALS9

1.13e-0423583MP:0008483
MousePhenoabnormal lymph node germinal center morphology

LGALS9C LGALS9B LGALS9

1.13e-0423583MP:0008522
MousePhenoabnormal T-helper 1 cell number

LGALS9C LGALS9B LGALS9

1.29e-0424583MP:0008085
MousePhenoabnormal lymph node secondary follicle morphology

LGALS9C LGALS9B LGALS9

1.46e-0425583MP:0002346
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.50e-0512783PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.50e-0512783IPR027970
DomainGal-bind_lectin

LGALS9C LGALS9B LGALS9

3.08e-0515783PF00337
DomainGal-bind_lectin

LGALS9C LGALS9B LGALS9

3.08e-0515783SM00908
DomainGALECTIN

LGALS9C LGALS9B LGALS9

3.08e-0515783PS51304
DomainGalectin_CRD

LGALS9C LGALS9B LGALS9

3.08e-0515783IPR001079
DomainGLECT

LGALS9C LGALS9B LGALS9

3.08e-0515783SM00276
DomainEFG_II

EFL1 GFM2

1.71e-045782PF14492
DomainEFG_III-V

EFL1 GFM2

2.55e-046782IPR009022
DomainEFG_C

EFL1 GFM2

2.55e-046782SM00838
DomainEFG_C

EFL1 GFM2

2.55e-046782PF00679
Domain-

EFL1 GFM2

3.57e-0477823.30.70.240
DomainEFG_V

EFL1 GFM2

3.57e-047782IPR000640
DomainG_TR_1

EFL1 GFM2

1.30e-0313782PS00301
DomainEFTu-like_2

EFL1 GFM2

2.52e-0318782IPR004161
DomainGTP_EFTU_D2

EFL1 GFM2

2.52e-0318782PF03144
DomainG_TR_2

EFL1 GFM2

2.52e-0318782PS51722
DomainCONNEXINS_1

GJC2 GJA10

2.81e-0319782PS00407
DomainTF_GTP-bd_dom

EFL1 GFM2

2.81e-0319782IPR000795
DomainEGF_3

ADAM19 MEGF8 C6 F9 NOTCH1

3.03e-03235785PS50026
DomainCONNEXINS_2

GJC2 GJA10

3.12e-0320782PS00408
DomainConnexin

GJC2 GJA10

3.12e-0320782IPR000500
DomainConnexin_CCC

GJC2 GJA10

3.12e-0320782IPR019570
DomainConnexin_N

GJC2 GJA10

3.12e-0320782IPR013092
DomainConnexin

GJC2 GJA10

3.12e-0320782PF00029
DomainConnexin_CCC

GJC2 GJA10

3.12e-0320782SM01089
DomainConnexin_CS

GJC2 GJA10

3.12e-0320782IPR017990
DomainCNX

GJC2 GJA10

3.12e-0320782SM00037
Domain-

EFL1 GFM2

3.43e-03217823.30.230.10
DomainEPHD

KMT2D RAI1

3.77e-0322782PS51805
DomainRibosomal_S5_D2-typ_fold_subgr

EFL1 GFM2

3.77e-0322782IPR014721
DomainEGF-like_dom

ADAM19 MEGF8 C6 F9 NOTCH1

3.87e-03249785IPR000742
DomainPAS_fold_3

PER2 NPAS4

4.12e-0323782IPR013655
DomainPAS_3

PER2 NPAS4

4.12e-0323782PF08447
DomainEGF_1

ADAM19 MEGF8 C6 F9 NOTCH1

4.28e-03255785PS00022
DomainNUDIX_BOX

TRPM2 NUDT17

4.48e-0324782PS00893
DomainPAS-assoc_C

PER2 NPAS4

4.48e-0324782IPR000700
DomainEGF-like_CS

ADAM19 MEGF8 C6 F9 NOTCH1

4.72e-03261785IPR013032
DomainEGF_2

ADAM19 MEGF8 C6 F9 NOTCH1

5.04e-03265785PS01186
DomainNUDIX

TRPM2 NUDT17

5.24e-0326782PS51462
DomainPAC

PER2 NPAS4

5.24e-0326782PS50113
DomainTransl_B-barrel

EFL1 GFM2

5.65e-0327782IPR009000
Domain-

TRPM2 NUDT17

6.07e-03287823.90.79.10
DomainNUDIX_hydrolase_dom-like

TRPM2 NUDT17

6.07e-0328782IPR015797
DomainNUDIX_hydrolase_dom

TRPM2 NUDT17

6.50e-0329782IPR000086
Domain-

LGALS9C LGALS9B LGALS9

7.36e-03957832.60.120.200
DomainEGF_Ca-bd_CS

MEGF8 F9 NOTCH1

7.80e-0397783IPR018097
DomainPSI

MEGF8 PLXNB3

7.87e-0332782PF01437
DomainPlexin_repeat

MEGF8 PLXNB3

7.87e-0332782IPR002165
DomainPAS

PER2 NPAS4

7.87e-0332782SM00091
DomainEGF_CA

MEGF8 F9 NOTCH1

8.25e-0399783PS01187
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

4.29e-10682420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

4.29e-10682425930072
Pubmed

Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.

LGALS9C LGALS9B LGALS9

1.26e-08382329458010
Pubmed

Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.

LGALS9C LGALS9B LGALS9

1.26e-08382319776007
Pubmed

Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.

LGALS9C LGALS9B LGALS9

1.26e-08382326582205
Pubmed

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

LGALS9C LGALS9B LGALS9

1.26e-0838239153289
Pubmed

Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.

LGALS9C LGALS9B LGALS9

1.26e-08382333316546
Pubmed

Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.

LGALS9C LGALS9B LGALS9

1.26e-08382318974023
Pubmed

Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.

LGALS9C LGALS9B LGALS9

1.26e-0838239038233
Pubmed

Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.

LGALS9C LGALS9B LGALS9

1.26e-08382323144904
Pubmed

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.

LGALS9C LGALS9B LGALS9

1.26e-08382329651447
Pubmed

Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.

LGALS9C LGALS9B LGALS9

1.26e-08382328704475
Pubmed

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.

LGALS9C LGALS9B LGALS9

1.26e-08382321146220
Pubmed

Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

LGALS9C LGALS9B LGALS9

1.26e-08382323836896
Pubmed

Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.

LGALS9C LGALS9B LGALS9

1.26e-0838237890611
Pubmed

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.

LGALS9C LGALS9B LGALS9

1.26e-08382322341088
Pubmed

Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.

LGALS9C LGALS9B LGALS9

1.26e-08382328990062
Pubmed

Galectin-9 Is a Novel Regulator of Epithelial Restitution.

LGALS9C LGALS9B LGALS9

1.26e-08382332380082
Pubmed

Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.

LGALS9C LGALS9B LGALS9

1.26e-08382323667648
Pubmed

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.

LGALS9C LGALS9B LGALS9

1.26e-08382318579572
Pubmed

Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.

LGALS9C LGALS9B LGALS9

1.26e-08382328877989
Pubmed

Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.

LGALS9C LGALS9B LGALS9

1.26e-08382319800850
Pubmed

The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.

LGALS9C LGALS9B LGALS9

1.26e-08382338987795
Pubmed

Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.

LGALS9C LGALS9B LGALS9

1.26e-08382316990264
Pubmed

Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.

LGALS9C LGALS9B LGALS9

1.26e-08382318005988
Pubmed

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

LGALS9C LGALS9B LGALS9

1.26e-08382323585851
Pubmed

Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

LGALS9C LGALS9B LGALS9

1.26e-08382324477688
Pubmed

A unique role for galectin-9 in angiogenesis and inflammatory arthritis.

LGALS9C LGALS9B LGALS9

1.26e-08382329433546
Pubmed

Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.

LGALS9C LGALS9B LGALS9

1.26e-08382337105392
Pubmed

Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.

LGALS9C LGALS9B LGALS9

1.26e-08382336479526
Pubmed

Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.

LGALS9C LGALS9B LGALS9

1.26e-08382323242525
Pubmed

Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.

LGALS9C LGALS9B LGALS9

1.26e-08382319851072
Pubmed

The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.

LGALS9C LGALS9B LGALS9

1.26e-08382333923930
Pubmed

Alarmin function of galectin-9 in murine respiratory tularemia.

LGALS9C LGALS9B LGALS9

1.26e-08382325898318
Pubmed

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.

LGALS9C LGALS9B LGALS9

1.26e-08382331937306
Pubmed

Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.

LGALS9C LGALS9B LGALS9

1.26e-08382321426359
Pubmed

Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.

LGALS9C LGALS9B LGALS9

1.26e-08382331969388
Pubmed

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.

LGALS9C LGALS9B LGALS9

1.26e-08382318282810
Pubmed

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.

LGALS9C LGALS9B LGALS9

1.26e-08382335241678
Pubmed

Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.

LGALS9C LGALS9B LGALS9

1.26e-08382324083426
Pubmed

Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.

LGALS9C LGALS9B LGALS9

1.26e-08382337279535
Pubmed

The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.

LGALS9C LGALS9B LGALS9

1.26e-08382325931247
Pubmed

Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.

LGALS9C LGALS9B LGALS9

1.26e-08382322627368
Pubmed

Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.

LGALS9C LGALS9B LGALS9

1.26e-08382333153471
Pubmed

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

LGALS9C LGALS9B LGALS9

1.26e-08382322052881
Pubmed

Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.

LGALS9C LGALS9B LGALS9

1.26e-08382317560833
Pubmed

Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.

LGALS9C LGALS9B LGALS9

1.26e-08382335643073
Pubmed

Galectin-9 functionally impairs natural killer cells in humans and mice.

LGALS9C LGALS9B LGALS9

1.26e-08382323408620
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FAM193B TNRC18 KMT2D PER2 MEGF8 TRAPPC12 PLA2G4B UBR4 SEC16A PLEC RALGAPA2 MED13 NOTCH1 ARHGAP33 RAI1

4.21e-081105821535748872
Pubmed

SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.

LGALS9C LGALS9B LGALS9

5.04e-08482338686388
Pubmed

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.

LGALS9C LGALS9B LGALS9

5.04e-08482322677125
Pubmed

Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.

LGALS9C LGALS9B LGALS9

5.04e-08482319234217
Pubmed

Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.

LGALS9C LGALS9B LGALS9

5.04e-08482335715604
Pubmed

Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

LGALS9C LGALS9B LGALS9

5.04e-08482319017954
Pubmed

Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.

LGALS9C LGALS9B LGALS9

5.04e-08482333963043
Pubmed

Galectin-9: A novel promoter of atherosclerosis progression.

LGALS9C LGALS9B LGALS9

5.04e-08482336459823
Pubmed

Newly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts.

LGALS9C LGALS9B LGALS9

5.04e-08482333107565
Pubmed

Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.

LGALS9C LGALS9B LGALS9

5.04e-08482329611821
Pubmed

Lipopolysaccharide mediates time-dependent macrophage M1/M2 polarization through the Tim-3/Galectin-9 signalling pathway.

LGALS9C LGALS9B LGALS9

5.04e-08482330763585
Pubmed

Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.

LGALS9C LGALS9B LGALS9

5.04e-08482333727589
Pubmed

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells.

LGALS9C LGALS9B LGALS9

5.04e-08482319362679
Pubmed

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.

LGALS9C LGALS9B LGALS9

5.04e-08482325578313
Pubmed

Intestinal Lamina Propria CD4+ T Cells Promote Bactericidal Activity of Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica Serovar Typhimurium Infection.

LGALS9C LGALS9B LGALS9

5.04e-08482329844236
Pubmed

Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.

LGALS9C LGALS9B LGALS9

5.04e-08482320463811
Pubmed

Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.

LGALS9C LGALS9B LGALS9

5.04e-08482332855403
Pubmed

Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate-recognition domain.

LGALS9C LGALS9B LGALS9

5.04e-08482323657851
Pubmed

[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].

LGALS9C LGALS9B LGALS9

5.04e-08482318826117
Pubmed

The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis.

LGALS9C LGALS9B LGALS9

5.04e-08482324333756
Pubmed

The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.

LGALS9C LGALS9B LGALS9

5.04e-08482338853593
Pubmed

Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.

LGALS9C LGALS9B LGALS9

5.04e-08482324958847
Pubmed

Galectin-9 binds IgM-BCR to regulate B cell signaling.

LGALS9C LGALS9B LGALS9

5.04e-08482330120235
Pubmed

[Expression of Galectin-9 and Tim-3 in lungs of mice with asthma].

LGALS9C LGALS9B LGALS9

5.04e-08482321575348
Pubmed

Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts.

LGALS9C LGALS9B LGALS9

5.04e-08482318346632
Pubmed

Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge.

LGALS9C LGALS9B LGALS9

5.04e-08482311839756
Pubmed

Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.

LGALS9C LGALS9B LGALS9

5.04e-08482319670381
Pubmed

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

LGALS9C LGALS9B LGALS9

5.04e-08482325450716
Pubmed

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

LGALS9C LGALS9B LGALS9

5.04e-08482316286920
Pubmed

Galectin-9 regulates the threshold of B cell activation and autoimmunity.

LGALS9C LGALS9B LGALS9

5.04e-08482334369876
Pubmed

Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.

LGALS9C LGALS9B LGALS9

5.04e-08482333203936
Pubmed

Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency.

LGALS9C LGALS9B LGALS9

5.04e-08482322021615
Pubmed

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.

LGALS9C LGALS9B LGALS9

1.26e-07582329242193
Pubmed

Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and alleviates pregnancy loss.

LGALS9C LGALS9B LGALS9

1.26e-07582328951537
Pubmed

Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner.

LGALS9C LGALS9B LGALS9

1.26e-07582334847625
Pubmed

Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.

LGALS9C LGALS9B LGALS9

1.26e-07582322469568
Pubmed

Astrocyte galectin-9 potentiates microglial TNF secretion.

LGALS9C LGALS9B LGALS9

1.26e-07582325158758
Pubmed

C/EBPzeta (CHOP/Gadd153) is a negative regulator of LPS-induced IL-6 expression in B cells.

LGALS9C LGALS9B LGALS9

1.26e-07582319782405
Pubmed

Embryonic implantation in galectin 1/galectin 3 double mutant mice.

LGALS9C LGALS9B LGALS9

1.26e-0758239566950
Pubmed

Feto-maternal immune regulation by TIM-3/galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy.

LGALS9C LGALS9B LGALS9

1.26e-07582326278059
Pubmed

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.

LGALS9C LGALS9B LGALS9

1.26e-07582337352334
Pubmed

Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.

LGALS9C LGALS9B LGALS9

1.26e-07582333664349
Pubmed

The glucose transporter 2 regulates CD8+ T cell function via environment sensing.

LGALS9C LGALS9B LGALS9

1.26e-07582337884694
Pubmed

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.

LGALS9C LGALS9B LGALS9

1.26e-07582321385853
Pubmed

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

LGALS9C LGALS9B LGALS9

2.51e-07682328394331
Pubmed

Tim3 binding to galectin-9 stimulates antimicrobial immunity.

LGALS9C LGALS9B LGALS9

2.51e-07682320937702
Pubmed

Galectins in mouse embryogenesis.

LGALS9C LGALS9B LGALS9

2.51e-0768238674632
Pubmed

Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

LGALS9C LGALS9B LGALS9

2.51e-07682323296703
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

2.94e-072482432212159
Pubmed

Role of galectin-1 in the developing mouse olfactory system.

LGALS9C LGALS9B LGALS9

4.39e-0778238873770
Pubmed

Mammalian galectins bind galactoseβ1-4fucose disaccharide, a unique structural component of protostomial N-type glycoproteins.

LGALS9C LGALS9B LGALS9

7.01e-07882323751344
Pubmed

Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer.

LGALS9C LGALS9B LGALS9

7.01e-07882331661141
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

8.76e-058822chr9q12
Cytoband13q12.3

BRCA2 KATNAL1

7.11e-042282213q12.3
Cytoband9p13.1

SPATA31A1 SPATA31A3

8.48e-04248229p13.1
Cytoband9q34.3

AJM1 SEC16A NOTCH1

9.28e-041068239q34.3
GeneFamilyGalectins

LGALS9C LGALS9B LGALS9

9.39e-0615513629
GeneFamilyGap junction proteins

GJC2 GJA10

1.74e-0322512314
GeneFamilyNudix hydrolase family

TRPM2 NUDT17

2.07e-0324512667
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC18 KMT2D

2.25e-0325512775
GeneFamilyComplement system|Sushi domain containing

C6 CR1

4.62e-0336512492
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GLTP GJC2 TEX52 PLXNB3 SEC14L5

5.50e-06137825ca8fdbe66a854e6283b22179ec9359ea9e86cd8e
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GLTP GJC2 TEX52 PLXNB3 SEC14L5

5.90e-06139825789edd3c98e7c5c1cc402c780fded9a9dfd1dfb8
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GLTP GJC2 TEX52 PLXNB3 SEC14L5

8.55e-06150825b30f52b94ce772632a1f2f5e0837db876cf92651
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GLTP GJC2 TEX52 PLXNB3 SEC14L5

8.55e-0615082505b9a9cbc5a95cdaf45d5f173e132acd4da9aa8a
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SCN10A RBAKDN TEX52 SEC14L5

1.07e-0574824a53f2e1f1044f3745a1eff5ba6275c8f1fbf3ae0
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SCN10A RBAKDN TEX52 SEC14L5

1.07e-0574824ae547cb8bbd780b19d9c6b555c27dad932dcc753
ToppCellwk_15-18-Hematologic-Myeloid-Basophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

EFL1 TRPM2 RALGAPA2 CR1 NOTCH1

2.54e-051888253638d85452de15a060146628fbbad9d2a36feb13
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLA2G4B GJC2 TEX52 SEC14L5

3.12e-05978247b17dc28454949a23701ab127300a29a8899d7d6
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLA2G4B GJC2 TEX52 SEC14L5

3.12e-05978244b74b3c5b9590a8215b7370b37e9723e9f040b9c
DiseaseMalignant neoplasm of breast

KMT2D CSF1 PER2 BRCA2 TRAPPC12 UBR4 SRARP RB1CC1 OLA1 NUDT17 NOTCH1

7.23e-0510747411C0006142
DiseaseWilliams Syndrome

MLXIPL LIMK1

1.72e-048742C0175702
DiseasePancreatic carcinoma, familial

BRCA2 PALLD

2.21e-049742C2931038
Diseaseelectrocardiography

SRARP SCN10A PROB1 PLEC ZFC3H1 PALLD CDH17

3.69e-04530747EFO_0004327
Diseaseage of onset of multiple sclerosis

PER2 CDH17

4.03e-0412742OBA_2001029
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

RFX7 MED13

8.24e-0417742DOID:0060307 (is_implicated_in)
Diseasepulmonary non-tuberculous mycobacterial infection

TRPM2 CHRM3

1.03e-0319742MONDO_0018469
Diseaseresponse to xenobiotic stimulus

UBR4 KCTD8 FBXL17 CHRM3

1.15e-03182744GO_0009410
DiseaseBREAST CANCER

BRCA2 RB1CC1

1.26e-0321742114480
DiseaseHeart valve disease

C6 NOTCH1

1.94e-0326742C0018824
DiseaseMammary Carcinoma, Human

KMT2D CSF1 BRCA2 RB1CC1 NUDT17 NOTCH1

2.06e-03525746C4704874
DiseaseMammary Neoplasms, Human

KMT2D CSF1 BRCA2 RB1CC1 NUDT17 NOTCH1

2.06e-03525746C1257931
DiseaseMalignant tumor of breast

BRCA2 RB1CC1

2.09e-0327742cv:C0006142
DiseaseBreast neoplasm

BRCA2 RB1CC1

2.09e-0327742cv:C1458155
DiseaseFamilial cancer of breast

BRCA2 RB1CC1

2.09e-0327742cv:C0346153
DiseaseMammary Neoplasms

KMT2D CSF1 BRCA2 RB1CC1 NUDT17 NOTCH1

2.10e-03527746C1458155
Diseaseobesity (implicated_via_orthology)

SEC16A MED13 NOTCH1 PLXNB3

2.12e-03215744DOID:9970 (implicated_via_orthology)
DiseaseBreast Carcinoma

KMT2D CSF1 BRCA2 RB1CC1 NUDT17 NOTCH1

2.32e-03538746C0678222

Protein segments in the cluster

PeptideGeneStartEntry
QLTFPTEQAAPPVCP

C9orf129

171

Q5T035
PPAPNCIVSQDFSRP

ADAM19

841

Q9H013
QPPCPNAVDCFVSRP

GJA10

191

Q969M2
LPSCPPFIPLNFEAT

EFL1

601

Q7Z2Z2
FPPFPSGRNCFPKQT

MACROH2A2

311

Q9P0M6
VPPGECFIQFLSEPT

CHRM3

216

P20309
PCERSVARPAEPAPF

AJM1

31

C9J069
PPITNIFPLPERFCE

ADGRL2

456

O95490
FCFPFDVEREPPSPA

DENND1C

51

Q8IV53
TPINEFSPACAPRTF

CDHR4

436

A6H8M9
VPAPDPTTAAFDCFP

RAI1

716

Q7Z5J4
AVCPLQTPPPDAFIR

RBAKDN

91

A6NC62
VPGNPFEEPTCINPF

RBSN

706

Q9H1K0
NFPFCTIDPNESRVP

OLA1

51

Q9NTK5
VLQPLFPTCFPPESG

SLC7A8

146

Q9UHI5
QSFCPSEVQPFLRVP

RB1CC1

586

Q8TDY2
LAPEFCPEAAPEFRP

DGKK

161

Q5KSL6
PCAPSPFPEVVELNV

KCTD8

36

Q6ZWB6
NPPVDPVSRSPKCFN

NOTCH1

1226

P46531
APEIRCPIPAFPDSV

IRAK2

96

O43187
PPFCPFAALEERPRV

NUDT17

66

P0C025
PFFPCSRQPCPHVVD

GJC2

241

Q5T442
TVPFSQPVCFPPRPR

LGALS9C

161

Q6DKI2
TVPFSQPVCFPPRPR

LGALS9B

161

Q3B8N2
TVPFSQPVCFPPRPR

LGALS9

161

O00182
TSQSSCPAVPFPAPV

PER2

836

O15055
QPEFPSRTSIPRQPC

PER2

946

O15055
PVIDSPDCVPFRDPA

PLXNB3

91

Q9ULL4
PVDAFTPLRIACTPP

PDZD7

721

Q9H5P4
EPAVPFPCGRVSVSQ

F9

171

P00740
PFAKVTVCFPPDPTA

MEGF8

2696

Q7Z7M0
RFCQEQGIPFPPISP

PLA2G4B

656

P0C869
QPSPVEPRGPFYFCR

RALGAPA2

1591

Q2PPJ7
VFSPTAAFPVPDVFP

PALLD

806

Q8WX93
TDCQIFTLTPPPAPR

ODAPH

41

Q17RF5
PVFTAFCAPLEPRPR

NPAS4

186

Q8IUM7
QVPTPGFFSPAPREC

ARHGAP33

1026

O14559
VPPSSPATQVCFEEP

CHFR

161

Q96EP1
QRPPRSTCQSFEPPE

CSF1

251

P09603
PVEPPSKDFCNFLPT

DMRT2

291

Q9Y5R5
PPVSPICTFVSPAAQ

BRCA2

3281

P51587
PCTAPLVAFQPCIPS

C6

116

P13671
SSVPVCEQIFCPSPP

CR1

411

P17927
SSVPVCEQIFCPSPP

CR1

861

P17927
CKTPEQFPFASPTIP

CR1

1396

P17927
TPAAPFPAQASECPV

FAM193B

281

Q96PV7
VPPQPAAPRSRDCFF

FBXL17

41

Q9UF56
DPCPPFLQTAVSPES

GGT6

336

Q6P531
PPFFDCLGSPVFTPI

GLTP

31

Q9NZD2
PVPPSKSFPLFNRCV

SLC44A3

166

Q8N4M1
NPPTCPSPVTVFEVQ

CDH17

336

Q12864
RFPTCPQIPVFLGSE

SEC14L5

26

O43304
KPPFQPRSVQEAPCS

C3orf86

46

P0DN24
IFPQPPPAETVTNCA

MOCS3

226

O95396
KEVLPFAFPDCSPPQ

CFAP221

531

Q4G0U5
PPDFPVSCQDEPFRD

KATNAL1

81

Q9BW62
GFFCTLAPSVQPVPR

TMEM178B

266

H3BS89
PEPVFFCTIEPPSLS

GFM2

486

Q969S9
SFPVSPLCPQEVPEA

SRARP

121

Q8NEQ6
VAPTDPRQFCVPSQF

SAMD7

36

Q7Z3H4
GPECQPFISSTPQFR

SPATA31A7

476

Q8IWB4
CFVLVPQSDIPTPSP

MED13

281

Q9UHV7
RSPPFECRIPSEVPS

PROB1

371

E7EW31
SPQETVPEFPCTFLP

MLXIPL

556

Q9NP71
VCVPPQEAFPNDPRV

TASOR

951

Q9UK61
PPPFLFCPLSSQRTE

TEPP

21

Q6URK8
GPECQPFISSTPQFR

SPATA31A3

476

Q5VYP0
PAFTSCPAPEPFAEL

TNRC18

2401

O15417
PFIQSCDPVPNEFPG

ZNF804B

1061

A4D1E1
VPVSPSFSDPACPVE

RNF111

526

Q6ZNA4
SFSDPACPVERPPQV

RNF111

531

Q6ZNA4
GPECQPFISSTPQFR

SPATA31A1

476

Q5TZJ5
VAPTTCPLQPVTDPF

SEC16A

41

O15027
CPLQPVTDPFAFSRQ

SEC16A

46

O15027
GPECQPFISSTPQFR

SPATA31A5

476

Q5VU36
PVPVCTIFSQRAPPA

TRAPPC12

156

Q8WVT3
FFSRSCPFPQPKAEP

SCN10A

931

Q9Y5Y9
LYPNCPVTRFPVPNE

TRPM2

1246

O94759
VCRLPATFPTQPDRP

TEX52

101

A6NCN8
VPPSPVECRNPFAFT

RFX7

916

Q2KHR2
AAVPSVCFLVPPPNQ

PLEC

986

Q15149
FPTPACQPYLQDVPR

PRR29

131

P0C7W0
ILDPSQAPRPFNEPC

ZNF746

411

Q6NUN9
CPEAPEPSFLREVPS

SMIM45

6

A0A590UK83
PPEEFPSASVSNICP

UBR4

2436

Q5T4S7
SPAPSPVQPPFFSEC

ZFC3H1

541

O60293
CPSSADTPVPLPFFV

HECTD3

556

Q5T447
SAEAFCPSPVTPRFQ

KMT2D

2431

O14686
CPPNCPPSFFPITVR

LIMK1

571

P53667
QFQPRCVSPIPVSPT

MYPN

806

Q86TC9