Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Astrocytoma	CDKN2A BRCA2 MLH1 TSC1	3.75e-06	25	23	4	HP:0009592
HumanPheno	Abnormal astrocyte morphology	CDKN2A BRCA2 MLH1 TSC1	4.55e-05	46	23	4	HP:0100707
HumanPheno	Glioma	CDKN2A BRCA2 MLH1 TSC1	5.39e-05	48	23	4	HP:0009733
HumanPheno	Ependymoma	CDKN2A MLH1 TSC1	7.43e-05	19	23	3	HP:0002888
HumanPheno	Medulloblastoma	CDKN2A BRCA2 MLH1	7.43e-05	19	23	3	HP:0002885
HumanPheno	Glioblastoma multiforme	CDKN2A BRCA2 MLH1	1.53e-04	24	23	3	HP:0012174
HumanPheno	Neoplasm of striated muscle	CDKN2A MLH1 TSC1	1.73e-04	25	23	3	HP:0009728
HumanPheno	Fibroma	CDKN2A BRCA2 LRP1 MLH1 TSC1	1.87e-04	124	23	5	HP:0010614
HumanPheno	Fibrous tissue neoplasm	CDKN2A BRCA2 LRP1 MLH1 TSC1	2.01e-04	126	23	5	HP:0012316
Domain	R3H	YTHDC2 R3HDM2	4.90e-04	9	70	2	SM00393
Domain	Grip	RGPD8 RGPD5	7.45e-04	11	70	2	SM00755
Domain	R3H	YTHDC2 R3HDM2	7.45e-04	11	70	2	PS51061
Domain	R3H	YTHDC2 R3HDM2	7.45e-04	11	70	2	PF01424
Domain	-	YTHDC2 R3HDM2	7.45e-04	11	70	2	3.30.1370.50
Domain	GRIP	RGPD8 RGPD5	7.45e-04	11	70	2	PF01465
Domain	R3H_dom	YTHDC2 R3HDM2	7.45e-04	11	70	2	IPR001374
Domain	Ran_BP1	RGPD8 RGPD5	8.92e-04	12	70	2	PF00638
Domain	GRIP_dom	RGPD8 RGPD5	8.92e-04	12	70	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	8.92e-04	12	70	2	PS50913
Domain	RANBD1	RGPD8 RGPD5	8.92e-04	12	70	2	PS50196
Domain	RanBD	RGPD8 RGPD5	1.05e-03	13	70	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	1.05e-03	13	70	2	IPR000156
Domain	PH_dom-like	IRS4 RGPD8 ARHGEF10 DAPP1 APBB1 TECPR1 RGPD5	1.06e-03	426	70	7	IPR011993
Domain	Ldl_recept_b	LRP1 LRP4	1.22e-03	14	70	2	PF00058
Domain	LDLRB	LRP1 LRP4	1.22e-03	14	70	2	PS51120
Domain	LY	LRP1 LRP4	1.41e-03	15	70	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP4	1.41e-03	15	70	2	IPR000033
Domain	cEGF	LRP1 LRP4	4.25e-03	26	70	2	IPR026823
Domain	cEGF	LRP1 LRP4	4.25e-03	26	70	2	PF12662
Pubmed	Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes.	CDKN2A BRCA2 MLH1	1.55e-07	6	70	3	18481196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SART3 LRIG3 AP5Z1 CCSER2 LARS1 MAML1 LRP4 LCOR NACAD	1.16e-06	529	70	9	14621295
Pubmed	Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.	APBB1 LRP1 ACE	3.49e-06	15	70	3	11436125
Pubmed	Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.	APBB1 LRP1 LRP4	3.49e-06	15	70	3	20205790
Pubmed	Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma.	CDKN2A MLH1	3.99e-06	2	70	2	20815811
Pubmed	Combined methylation of p16 and hMLH1 (CMETH2) discriminates a subpopulation with better prognosis in colorectal cancer patients with microsatellite instability tumors.	CDKN2A MLH1	3.99e-06	2	70	2	25576161
Pubmed	Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.	CDKN2A MLH1	3.99e-06	2	70	2	15083191
Pubmed	Clinical and prognosis value of the CIMP status combined with MLH1 or p16 INK4a methylation in colorectal cancer.	CDKN2A MLH1	3.99e-06	2	70	2	28730335
Pubmed	Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions.	CDKN2A MLH1	3.99e-06	2	70	2	19697618
Pubmed	[Methylation of p16 and hMLH1 genes in esophageal squamous cell carcinoma and reflux esophagitis].	CDKN2A MLH1	3.99e-06	2	70	2	22169643
Pubmed	Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity.	BRCA2 MLH1	3.99e-06	2	70	2	24302565
Pubmed	Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype.	CDKN2A MLH1	3.99e-06	2	70	2	23073540
Pubmed	ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.	CDKN2A BRCA2	3.99e-06	2	70	2	24162189
Pubmed	Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences.	EPHB3 TYRO3	3.99e-06	2	70	2	7784069
Pubmed	Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location.	CDKN2A MLH1	3.99e-06	2	70	2	18161865
Pubmed	The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1).	BRCA2 MLH1	3.99e-06	2	70	2	32040686
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CCSER2 APBB1 OLFM1 DYNC1H1 RGPD5	4.55e-06	120	70	5	31413325
Pubmed	Gene Promoter Methylation in Endometrial Carcinogenesis.	CDKN2A MLH1	1.20e-05	3	70	2	30430425
Pubmed	Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma.	CDKN2A BRCA2	1.20e-05	3	70	2	12556369
Pubmed	Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma.	CDKN2A MLH1	1.20e-05	3	70	2	23244153
Pubmed	Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.	CDKN2A TSC1	1.20e-05	3	70	2	22064482
Pubmed	Phosphorylation of LRP1 regulates the interaction with Fe65.	APBB1 LRP1	1.20e-05	3	70	2	21968187
Pubmed	Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas.	CDKN2A TSC1	1.20e-05	3	70	2	16909113
Pubmed	Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.	CDKN2A MLH1	1.20e-05	3	70	2	17276933
Pubmed	High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans.	CDKN2A MLH1	1.20e-05	3	70	2	28748002
Pubmed	EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.	CDKN2A MLH1	1.20e-05	3	70	2	21538028
Pubmed	A study of the frequency of methylation of gene promoter regions in colorectal cancer in the Taiwanese population.	CDKN2A MLH1	1.20e-05	3	70	2	23640413
Pubmed	EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.	CDKN2A MLH1	1.20e-05	3	70	2	20978327
Pubmed	Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.	CDKN2A MLH1	1.20e-05	3	70	2	21747645
Pubmed	Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.	APBB1 LRP1	1.20e-05	3	70	2	21650223
Pubmed	Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families.	CDKN2A BRCA2	1.20e-05	3	70	2	20195775
Pubmed	Aberrant DNA methylation of P16, MGMT, hMLH1 and hMSH2 genes in combination with the MTHFR C677T genetic polymorphism in gastric cancer.	CDKN2A MLH1	1.20e-05	3	70	2	23803092
Pubmed	Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype.	CDKN2A MLH1	1.20e-05	3	70	2	21849808
Pubmed	Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells.	LARS1 TSC1	1.20e-05	3	70	2	34325132
Pubmed	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.	CDKN2A TSC1	1.20e-05	3	70	2	29133867
Pubmed	Association between p16, hMLH1 and E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods in Kashmiris with gastric tumors.	CDKN2A MLH1	1.20e-05	3	70	2	22502664
Pubmed	Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer's disease in the Chinese population: a meta-analysis of case-control studies.	LRP1 ACE	1.20e-05	3	70	2	25730041
Pubmed	Large-scale genotyping identifies 41 new loci associated with breast cancer risk.	CDKN2A CCDC88C BRCA2 EMID1	1.73e-05	76	70	4	23535729
Pubmed	Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs.	CDKN2A MLH1	2.39e-05	4	70	2	24400091
Pubmed	Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.	CDKN2A MLH1	2.39e-05	4	70	2	18177869
Pubmed	Can a phenotype for recessive inheritance in breast cancer be defined?	CDKN2A BRCA2	2.39e-05	4	70	2	20549370
Pubmed	Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma.	CDKN2A MLH1	2.39e-05	4	70	2	18199718
Pubmed	Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation.	BRCA2 MLH1	2.39e-05	4	70	2	35205366
Pubmed	Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype.	CDKN2A MLH1	2.39e-05	4	70	2	17671701
Pubmed	Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.	BRCA2 MLH1	2.39e-05	4	70	2	19383374
Pubmed	Contribution of CDKN2A/P16 ( INK4A ), P14 (ARF), CDK4 and BRCA1/2 germline mutations in individuals with suspected genetic predisposition to uveal melanoma.	CDKN2A BRCA2	2.39e-05	4	70	2	20842456
Pubmed	Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.	CDKN2A MLH1	2.39e-05	4	70	2	16619216
Pubmed	BRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma.	CDKN2A BRCA2	2.39e-05	4	70	2	17624602
Pubmed	The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.	APBB1 LRP1	2.39e-05	4	70	2	12888553
Pubmed	BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.	CDKN2A BRCA2	2.39e-05	4	70	2	25356972
Pubmed	Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.	CDKN2A MLH1	2.39e-05	4	70	2	23804521
Pubmed	Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.	CDKN2A MLH1	2.39e-05	4	70	2	21375764
Pubmed	Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing.	APBB1 LRP1	2.39e-05	4	70	2	20568118
Pubmed	Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.	APBB1 LRP1	2.39e-05	4	70	2	24284412
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	2.39e-05	4	70	2	9480752
Pubmed	Promoter methylation profile in gallbladder cancer.	CDKN2A MLH1	3.98e-05	5	70	2	16699861
Pubmed	mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.	CDKN2A TSC1	3.98e-05	5	70	2	25584893
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP4	3.98e-05	5	70	2	19047013
Pubmed	Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.	SART3 APBB1	3.98e-05	5	70	2	25342469
Pubmed	Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.	CDKN2A TSC1	3.98e-05	5	70	2	31896747
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	WDR3 LENG8 CCDC88C BRCA2 CEP95 MAML1 TSC1 ACE DYNC1H1	5.25e-05	853	70	9	28718761
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDKN2A CCDC88C VPS13D IRS4 ARHGEF10 CEP95 SYDE2 CCSER2 APBB1	5.65e-05	861	70	9	36931259
Pubmed	[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas].	CDKN2A BRCA2	5.96e-05	6	70	2	19548527
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	APBB1 LRP1	5.96e-05	6	70	2	9837937
Pubmed	CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.	CDKN2A BRCA2	5.96e-05	6	70	2	19258476
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	LRP1 MMP17	5.96e-05	6	70	2	14645246
Pubmed	Ductal pancreatic cancer in humans and mice.	CDKN2A BRCA2	5.96e-05	6	70	2	16869739
Pubmed	An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.	TYRO3 LRP1	5.96e-05	6	70	2	24509082
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	TYRO3 EXOC6 FARSA DYNC1H1	7.66e-05	111	70	4	21163940
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD5	8.33e-05	7	70	2	15710750
Pubmed	Consortium analysis of 7 candidate SNPs for ovarian cancer.	CDKN2A BRCA2	8.33e-05	7	70	2	18431743
Pubmed	Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.	CDKN2A BRCA2	8.33e-05	7	70	2	21987080
Pubmed	ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy.	LRP1 ACE	1.11e-04	8	70	2	20381197
Pubmed	APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.	LRP1 LRP4	1.42e-04	9	70	2	23986861
Pubmed	Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.	CDKN2A BRCA2	1.78e-04	10	70	2	37592023
Pubmed	Genome-wide association analysis identifies susceptibility loci for migraine without aura.	LRP1 MMP17	1.78e-04	10	70	2	22683712
Pubmed	Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.	CDKN2A BRCA2 MLH1	1.90e-04	55	70	3	19536092
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	LENG8 IRS4 CCSER2 APBB1 YTHDC2	1.93e-04	263	70	5	34702444
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	BRCA2 MLH1 TSC1	2.11e-04	57	70	3	23788249
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP4	2.17e-04	11	70	2	24639464
Pubmed	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	LRP1 ACE	2.17e-04	11	70	2	19105203
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	SART3 WDR3 FARSA IRS4 DYNC1H1	2.25e-04	272	70	5	25315684
Pubmed	Genetically engineered mouse models of brain cancer and the promise of preclinical testing.	CDKN2A BRCA2	2.60e-04	12	70	2	19076778
Pubmed	Mouse models in tumor suppression.	CDKN2A BRCA2	2.60e-04	12	70	2	9917000
Pubmed	Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.	BRCA2 MLH1	2.60e-04	12	70	2	16391231
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SART3 WDR3 LENG8 IRS4 CCSER2 YTHDC2	2.62e-04	440	70	6	34244565
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	CDKN2A BRCA2 MLH1	2.84e-04	63	70	3	19351817
Pubmed	Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.	FARSA LARS1	3.07e-04	13	70	2	11829477
Pubmed	A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.	BRCA2 MLH1	3.07e-04	13	70	2	30760716
Pubmed	Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.	LRP1 LRP4	3.07e-04	13	70	2	16207730
Pubmed	DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.	CDKN2A MLH1	3.58e-04	14	70	2	20338046
Pubmed	Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.	SART3 FARSA DYNC1H1	3.88e-04	70	70	3	35008187
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	CDKN2A BRCA2 TSC1	4.05e-04	71	70	3	28319113
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	CCDC88C MYO15A	4.12e-04	15	70	2	36260679
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	BRCA2 MLH1	4.71e-04	16	70	2	27760317
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SART3 LENG8 IRS4 LARS1 APBB1 MLH1 TSC1 YTHDC2	5.69e-04	934	70	8	33916271
Pubmed	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).	GYS1 LRP1 ACE	5.74e-04	80	70	3	19420105
Pubmed	A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.	BRCA2 MLH1	5.98e-04	18	70	2	32845237
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	CDKN2A BRCA2 MLH1	6.62e-04	84	70	3	19237606
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	CDKN2A WDR3 LENG8 FARSA IRS4 LARS1 YTHDC2	6.70e-04	731	70	7	29298432
Cytoband	17q23.3	CEP95 ACE	9.70e-04	30	70	2	17q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	MIGA2 NOXA1 OLFM1 TSC1	1.57e-03	325	70	4	chr9q34
Cytoband	11q12.2	TKFC CNTF	1.64e-03	39	70	2	11q12.2
Cytoband	10q11.22	PTPN20 GPRIN2	1.81e-03	41	70	2	10q11.22
Cytoband	12q13.3	LRP1 R3HDM2	2.78e-03	51	70	2	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	FAM170B PTPN20 GPRIN2	3.02e-03	188	70	3	chr10q11
GeneFamily	Low density lipoprotein receptors	LRP1 LRP4	3.48e-04	13	39	2	634
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000_k-means-cluster#4	TYRO3 CCDC88C IRS4 EMID1 OLFM1	2.24e-05	104	69	5	Facebase_RNAseq_e10.5_Olfactory Pit_1000_K4
Disease	Adult only	BRCA2 MLH1	7.13e-05	6	65	2	C3842001
Disease	ficolin-1 measurement	APBB1 OLFM1	7.13e-05	6	65	2	EFO_0008134
Disease	pre-malignant neoplasm (implicated_via_orthology)	CDKN2A ACE	1.70e-04	9	65	2	DOID:0060071 (implicated_via_orthology)
Disease	Pancreatic carcinoma, familial	CDKN2A BRCA2	1.70e-04	9	65	2	C2931038
Disease	Benign tumor of pancreas	CDKN2A BRCA2	3.67e-04	13	65	2	C0347284
Disease	leukemia (is_implicated_in)	CDKN2A ACE	3.67e-04	13	65	2	DOID:1240 (is_implicated_in)
Disease	skin melanoma (is_implicated_in)	CDKN2A BRCA2	4.27e-04	14	65	2	DOID:8923 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TSC1 ACE	5.62e-04	16	65	2	DOID:0110861 (implicated_via_orthology)
Disease	lung cancer (is_implicated_in)	IRS4 MLH1 ACE	5.91e-04	74	65	3	DOID:1324 (is_implicated_in)
Disease	Pancreatic carcinoma	CDKN2A BRCA2	7.98e-04	19	65	2	C0235974
Disease	chronic myeloid leukemia (is_marker_for)	CDKN2A ACE	1.62e-03	27	65	2	DOID:8552 (is_marker_for)
Disease	Cerebral Hemorrhage	ACE CNTF	1.74e-03	28	65	2	C2937358
Disease	Neoplasm of uncertain or unknown behavior of ovary	BRCA2 MLH1	1.87e-03	29	65	2	C0496920
Disease	Ovarian Carcinoma	BRCA2 MLH1	2.00e-03	30	65	2	C0029925
Disease	Breast Cancer, Familial	BRCA2 MLH1	2.00e-03	30	65	2	C0346153
Disease	colorectal cancer	ARHGEF10 LRP1 MLH1 OLFM1 NACAD DCAF12	2.13e-03	604	65	6	MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPDAAIWLGDSLGSM	ARHGEF10	1261	O15013
YRSMPTSTWADGLEG	CTXN3	56	Q4LDR2
AGDSWRSMYETPSLE	ACE	821	P12821
GMRNSAASDEDSSWA	APBB1	211	O00213
REMSPSDSLSLAWDH	AP5Z1	91	O43299
MSAAASPASERGWKS	C3orf70	1	A6NLC5
RSSMWDQGDILESGS	ATP10B	681	O94823
EAADSAGNSPVMWAA	ANKRD63	111	C9JTQ0
RPWSSTDSDGSVRSM	R3HDM2	326	Q9Y2K5
GLWTEAASSLREAMS	NOXA1	136	Q86UR1
AASSLREAMSKWPEG	NOXA1	141	Q86UR1
PLSGSDRAWMWSASD	RGPD5	1121	Q99666
PLSGSDRAWMWSASD	RGPD8	1121	O14715
TSEEWMSDLDDLLGS	MAML1	1001	Q92585
SLDASSSMSVAPWAG	IRAK2	536	O43187
DSPQMTAPSLDDDGW	LRIG3	791	Q6UXM1
FGNSWDSDEDMSTRP	MYO15A	2321	Q9UKN7
WDASLPRIEAASMSG	LRP1	1406	Q07954
LQMSSLESSGADPDW	LENG8	531	Q96PV6
DASTDLAMRSWPSEL	CCDC88C	1501	Q9P219
RKSMLDAGPDSWGSD	LCOR	301	Q96JN0
TSGSRFGSWMTDPLA	OLFM1	241	Q99784
DPDSMEWDGESSLSA	PLK5	126	Q496M5
EADSDVASASSPFWM	EPHB3	136	P54753
LWDARGMEESLTTSD	MIGA2	156	Q7L4E1
RAASAGSYSEWSMTP	IL22RA2	136	Q969J5
ADYDWTMSEPDGRAS	EXOC6	616	Q8TAG9
RGMRDWSSSPSSESS	FAM170B	66	A6NMN3
EEPSESGSDPSMWTA	PTPN20	71	Q4JDL3
LSPSDSSDGTYMWDE	CCSER2	501	Q9H7U1
GSDMAALPAWRATSG	GASK1A	176	Q9UFP1
GSSMEPSADWLATAA	CDKN2A	6	P42771
PAADVWTSMEAASGE	FCAMR	386	Q8WWV6
SESLGAEVDPDMSWS	BRCA2	181	P51587
AEVDPDMSWSSSLAT	BRCA2	186	P51587
SENSGSDWDSAPETM	C6orf47	36	O95873
AWISDTMAVSGSRDG	DCAF12	191	Q5T6F0
DSADGMPVASTDQWS	CNTF	51	P26441
MSTQDPSDLWSRSDG	DAPP1	11	Q9UN19
GSLPSMDSGSLWEED	FAM131C	261	Q96AQ9
LSSEMLGPSWDGDEA	CEP95	161	Q96GE4
TDSTSDGRPAWMRTL	DYNC1H1	4366	Q14204
ASAELESGAMPWSLL	GDF9	36	O60383
EASSASLEPMWSGST	EMID1	106	Q96A84
LAPEDETSNSAWMLG	GPRIN2	176	O60269
TLSMSSLPGLEDWED	GYS1	6	P13807
AMASSAESSPGEYEW	SART3	71	Q15020
DDSDLEGRTSFMWAA	INVS	316	Q9Y283
PGAMWLSTATGSRSD	IRS4	51	O14654
WTLDPESADMFDNGS	FOXD2	201	O60548
MDGWSGDRARAAAPT	SYDE2	126	Q5VT97
ELSPEMISSGSWRDR	FARSA	191	Q9Y285
DTSPLLDPNSWSDTM	SAMD7	411	Q7Z3H4
PSTLDDAMRWSDGAS	MMP17	476	Q9ULZ9
EMVANWDSLRSGPAS	LARS1	776	Q9P2J5
AMLALDSPESGWTEE	MLH1	586	P40692
AGPFSSRWETTMGEA	TSC1	1056	Q92574
MSPADALVWAGTAAT	SLC26A1	466	Q9H2B4
TSRGLPTDRYMWSDA	TECPR1	836	Q7Z6L1
MEENPTLESEAWGSS	TMC4	1	Q7Z404
AADSDGWDSAPSDLR	PHF23	71	Q9BUL5
PMSSEELPLASSWRS	YTHDC2	1181	Q9H6S0
ALEGGWESSLPASRM	TMEM221	241	A6NGB7
MEPSSWSGSESPAEN	TEAD1	1	P28347
DGALWSMSLSPDQRG	WDR3	496	Q9UNX4
TSLPAWSAAMDAGLE	TKFC	466	Q3LXA3
SEFPELWMDSAAGSA	PRR23C	161	Q6ZRP0
LSSSNASVAWMPGAD	TYRO3	236	Q06418
AASRSWLSMDAPELG	RNF39	61	Q9H2S5
ESAKSEDWMGSSVDP	VPS13D	2831	Q5THJ4
TDWGNTPRIEASSMD	LRP4	571	O75096
TPWAAQEDADSTLGM	NACAD	1011	O15069