Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein deglycation	PARK7 FN3K	4.84e-05	2	144	2	GO:0036525
GeneOntologyBiologicalProcess	negative regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.84e-05	2	144	2	GO:1900124
GeneOntologyBiologicalProcess	regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.84e-05	2	144	2	GO:1900123
GeneOntologyBiologicalProcess	nodal receptor complex assembly	LEFTY2 LEFTY1	4.84e-05	2	144	2	GO:0038099
GeneOntologyCellularComponent	microbody lumen	HSPD1 EPHX2 LONP2 GRHPR HSD17B4	3.94e-05	55	145	5	GO:0031907
GeneOntologyCellularComponent	peroxisomal matrix	HSPD1 EPHX2 LONP2 GRHPR HSD17B4	3.94e-05	55	145	5	GO:0005782
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LARP6 PPRC1 RBL2 USP28 TAF1C CCT7 NR1D1 LRP1B RPH3A FN3K EEF1A2 CASK ABLIM1 PTPRD GRHPR MICAL2 SIPA1L1 DDX18 YLPM1 HSD17B4 HECTD1 PADI2 MED13 VCPIP1	1.01e-09	1285	147	24	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CRYBG2 EPPK1 KMT2B EP400 PPRC1 INPPL1 NLRX1 OBSCN EML2 ATP13A2 ITGB4 EML3 NCOR1 FASN ARHGEF40 SHANK2 PTPRS TRIM28 INTS11 GNAZ HECTD1 MED13	1.70e-09	1105	147	22	35748872
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	HSPD1 ACAT2 PARK7 EML2 CCT7 ITGB4 NCCRP1 ARHGEF40 EXD2 SIPA1L1 FLAD1 DDX18 YLPM1 HSD17B12 GNAZ RHOT1	9.54e-08	732	147	16	34732716
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HSPD1 EP400 ACAT2 PARK7 TAF1C CGAS RPS14 CCT7 MACROH2A1 LBR TUFM NCCRP1 FASN ARHGEF40 GRHPR PIK3C2A TRIM28 WDR6 MICAL2 DDX18 INTS11	2.80e-07	1353	147	21	29467282
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MRI1 EPPK1 POGK PARK7 RPS14 LAP3 TUFM NBAS FASN GRHPR TRIM28 INTS11 ALDH4A1 RHOT1 VCPIP1	3.40e-07	704	147	15	29955894
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	B4GALT2 CRYBG2 FMO3 PARK7 ESRRG OBSCN GON4L LENEP ATP13A2 TBX19 LEFTY1 HMCN1 KCNJ10 INTS11 NID1 SHE ALDH4A1 PADI2	4.02e-07	1031	147	18	16710414
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MPP2 USP28 PARK7 MACROH2A1 GABBR2 RPH3A EEF1A2 CASK NCOR1 ABLIM1 PTPRD SHANK2 PTPRS TRIM28 SIPA1L1 KCNJ10 YLPM1	7.43e-07	963	147	17	28671696
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	HSPD1 MRI1 ACAT2 USP28 PARK7 RPS14 CCT7 LBR LAP3 EEF1A2 FASN GRHPR TRIM28 FLAD1 DDX18 HSD17B4	1.07e-06	878	147	16	37223481
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	HSPD1 FYTTD1 PARK7 INPPL1 RPS14 CCT7 LBR TUFM NCOR1 ABLIM1 FASN GRHPR PIK3C2A TRIM28 MICAL2 SIPA1L1 DDX18 HECTD1 MED13	1.43e-06	1247	147	19	27684187
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	HSPD1 ACAT2 PDK2 PARK7 NLRX1 RPS14 DNAJC27 CCT7 LAP3 TUFM FASN ALDH4A1 MRPL34 SARDH HSD17B4 RHOT1	2.12e-06	926	147	16	20877624
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	HSPD1 RPS14 CCT7 LBR TUFM NCOR1 FASN TRIM28 EXD2 HSD17B12	2.25e-06	344	147	10	36282215
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TRMT9B EP400 POGK USP28 DNAH2 CCDC180	5.25e-06	103	147	6	10819331
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HSPD1 PDK2 RPS14 CCT7 MACROH2A1 LBR TUFM CASK NBAS PIK3C2A WDR6 EXD2 FLAD1 DDX18 HSD17B12 ALDH4A1 MRPL34 HSD17B4 RHOT1 VCPIP1	5.33e-06	1496	147	20	32877691
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	HSPD1 LONP2 SMARCAL1 RPS14 CCT7 LBR TUFM FASN WDR6 HSD17B12	5.82e-06	383	147	10	29331416
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	EPHX2 CYP2A6 CYP2A7	6.10e-06	9	147	3	37838304
Pubmed	Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.	DNAH2 LEFTY2 LEFTY1	6.10e-06	9	147	3	10330409
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	HSPD1 MPP2 PDK2 PARK7 CCT7 MACROH2A1 GABBR2 LRP1B RPH3A RYR2 ABLIM1 SHANK2 TRIM28 SIPA1L1 SLC4A10 AK1 VCPIP1	7.01e-06	1139	147	17	36417873
Pubmed	Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration.	ESRRB LEFTY2 LEFTY1	8.69e-06	10	147	3	25536399
Pubmed	The protein interaction landscape of the human CMGC kinase group.	EP400 RBL2 ESRRG ZFP14 MACROH2A1 LBR EEF1A2 CASK SHANK2 WDR6 SIPA1L1 MAPKAPK3 MED13	8.71e-06	695	147	13	23602568
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	HSPD1 ACAT2 PDK2 PARK7 NLRX1 RPS14 DNAJC27 CCT7 LAP3 TUFM FASN ALDH4A1 MRPL34 SARDH HSD17B4 RHOT1	9.93e-06	1047	147	16	18614015
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	HSPD1 MPP2 PARK7 RPS14 CCT7 RPH3A TUFM EEF1A2 CASK ABLIM1 FASN SHANK2 PTPRS TRIM28 MICAL2 SIPA1L1 SLC4A10 GNAZ RHOT1	1.03e-05	1431	147	19	37142655
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	HSPD1 EPPK1 KMT2B RPS14 CCT7 MACROH2A1 LBR TUFM FASN DDX18 HSD17B12 ALDH4A1 HSD17B4	1.11e-05	711	147	13	33022573
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HSPD1 OR1M1 CYP2A6 LARP6 PPRC1 DNAH2 MACROH2A1 TUFM RYR2 EEF1A2 NCOR1 FASN SHANK2 YLPM1 CC2D2A AK1 HSD17B4 POFUT2 MED13	1.15e-05	1442	147	19	35575683
Pubmed	Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.	LEFTY2 LEFTY1 POFUT2	1.19e-05	11	147	3	27297885
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	RPS14 ZFP14 ITGB4 TUFM GREB1L NEK4 TRIM28 INTS11 NID1 HECTD1 BMP15	1.26e-05	513	147	11	25798074
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	HSPD1 KMT2B ZC3H13 OBSCN DNAH2 RPS14 SLC28A3 TUFM EEF1A2 TMCO4 GRHPR ZFR2 SAMD3	1.59e-05	736	147	13	29676528
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	HSPD1 RBL2 RPS14 CCT7 TUFM FASN WDR6 MAPKAPK3 HECTD1 RHOT1	1.65e-05	432	147	10	23455922
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	HSPD1 EPHX2 PDK2 TUFM GRHPR ALDH4A1 SARDH HSD17B4 RHOT1	1.66e-05	343	147	9	28130547
Pubmed	Expression of estrogen-related receptors in ovarian cancer and impact on survival.	ESRRB ESRRG	1.77e-05	2	147	2	34089362
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	1.77e-05	2	147	2	12325023
Pubmed	LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.	LEFTY2 LEFTY1	1.77e-05	2	147	2	32745796
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	1.77e-05	2	147	2	16636685
Pubmed	LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.	LEFTY2 LEFTY1	1.77e-05	2	147	2	20056823
Pubmed	Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.	LEFTY2 LEFTY1	1.77e-05	2	147	2	10053005
Pubmed	Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.	LEFTY2 LEFTY1	1.77e-05	2	147	2	11100524
Pubmed	Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.	LEFTY2 LEFTY1	1.77e-05	2	147	2	24147624
Pubmed	Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels.	EPHX2 ADORA1	1.77e-05	2	147	2	27629787
Pubmed	Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.	LEFTY2 LEFTY1	1.77e-05	2	147	2	20171171
Pubmed	Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.	LEFTY2 LEFTY1	1.77e-05	2	147	2	9496783
Pubmed	A functional role of LEFTY during progesterone therapy for endometrial carcinoma.	LEFTY2 LEFTY1	1.77e-05	2	147	2	29268772
Pubmed	Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.	NR1D1 NCOR1	1.77e-05	2	147	2	20581824
Pubmed	Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1).	NR1D1 NCOR1	1.77e-05	2	147	2	24794873
Pubmed	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	LEFTY2 LEFTY1	1.77e-05	2	147	2	33409963
Pubmed	LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.	LEFTY2 LEFTY1	1.77e-05	2	147	2	29230527
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	1.77e-05	2	147	2	2322567
Pubmed	Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.	LEFTY2 LEFTY1	1.77e-05	2	147	2	17038673
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	1.77e-05	2	147	2	7864805
Pubmed	Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.	ESRRB ESRRG	1.77e-05	2	147	2	10072763
Pubmed	An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells.	ESRRB ESRRG	1.77e-05	2	147	2	19631715
Pubmed	Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan.	CYP2A6 FMO3	1.77e-05	2	147	2	33038907
Pubmed	The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy.	NLRX1 TUFM	1.77e-05	2	147	2	23321557
Pubmed	Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.	LEFTY2 LEFTY1	1.77e-05	2	147	2	29286065
Pubmed	The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.	PTPRD PTPRS	1.77e-05	2	147	2	9566880
Pubmed	Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.	LEFTY2 LEFTY1	1.77e-05	2	147	2	21401636
Pubmed	Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.	LEFTY2 LEFTY1	1.77e-05	2	147	2	15640253
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	HSPD1 EPHX2 PARK7 OBSCN CCT7 LAP3 TUFM FASN PTPRD GRHPR HSD17B12 AK1 ALDH4A1 HSD17B4	1.82e-05	859	147	14	31536960
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	HSPD1 EPPK1 RBL2 RPS14 CCT7 EEF1A2 CASK PIK3C2A TRIM28 WDR6 SLC4A10 HECTD1	1.88e-05	639	147	12	23443559
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	CYP2A6 FMO3 GABBR2 NEK4 LEFTY2 LEFTY1 HSD17B4 BMP15	2.38e-05	275	147	8	20734064
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	HSPD1 MPP2 PARK7 RPS14 CCT7 RPH3A TUFM EEF1A2 ABLIM1 GUCY2D AK1	2.47e-05	552	147	11	36293380
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK1 ITGB4 TUFM NBAS FASN ARHGEF40 HECTD1	2.57e-05	202	147	7	33005030
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2B EP400 ZC3H13 NR1D1 NCOR1 ABLIM1 FASN SH2D4A TRIM28 SIPA1L1 YLPM1 MED13 VCPIP1	2.69e-05	774	147	13	15302935
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EP400 USP28 PARK7 SMARCAL1 DNAJB4 CCT7 MACROH2A1 TUFM NCOR1 FASN TRIM28 DDX18 YLPM1 AK1 MED13	2.78e-05	1014	147	15	32416067
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	COL12A1 RPS14 MACROH2A1 TUFM JARID2 TRIM28 CCDC180	2.83e-05	205	147	7	27976729
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	HSPD1 EPPK1 ITGB4 TUFM NCOR1	2.97e-05	84	147	5	25670202
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	HSPD1 EPPK1 PARK7 RPS14 CCT7 MACROH2A1 TUFM FASN DDX18 HSD17B4	2.97e-05	463	147	10	34901782
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	HSPD1 RPS14 CCT7 LBR TUFM FASN TRIM28 WDR6 EXD2 HSD17B12 RHOT1	3.06e-05	565	147	11	33567341
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	HSPD1 EPPK1 EP400 RPS14 CCT7 MACROH2A1 LBR TUFM ABLIM1 FASN TRIM28 EXD2 DDX18 YLPM1 HSD17B4	3.11e-05	1024	147	15	24711643
Pubmed	MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.	HSPD1 PARK7 CCT7 LBR TUFM FASN TRIM28 DDX18	3.23e-05	287	147	8	36180891
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	HSPD1 MACROH2A1 LBR TUFM ABLIM1 FASN TRIM28 FLAD1 HECTD1 RHOT1 VCPIP1	3.36e-05	571	147	11	37167062
Pubmed	PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.	HSPD1 RPS14 CCT7 LBR TUFM FASN TRIM28 HSD17B4	3.47e-05	290	147	8	32929329
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HSPD1 COL12A1 EPPK1 PARK7 RPS14 DNAJB4 CCT7 LBR NCOR1 FASN ARHGEF40 WDR6 MAPKAPK3 HSD17B12 MRPL34 HECTD1 POFUT2	3.67e-05	1297	147	17	33545068
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	HSPD1 NLRX1 OBSCN LAP3 TUFM GRHPR ALDH4A1 HSD17B4 RHOT1	3.85e-05	382	147	9	29222160
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	FYTTD1 USP28 PARK7 SMARCAL1 CCT7 ATP13A2 ITGB4 CASK GREB1L EXD2 FLAD1 INTS11 HSD17B4 RHOT1	4.07e-05	925	147	14	28986522
Pubmed	Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF.	HSPD1 RPS14 LBR TUFM HSD17B12	4.15e-05	90	147	5	30459231
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	HSPD1 RPS14 CCT7 MACROH2A1 LBR TUFM CASK FASN WDR6 HSD17B12	4.32e-05	484	147	10	31995728
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	HSPD1 EP400 ZC3H13 CGAS RPS14 MACROH2A1 LBR LAP3 TUFM EEF1A2 NCOR1 FASN TRIM28 DDX18 HSD17B12 ALDH4A1 HSD17B4	4.48e-05	1318	147	17	30463901
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	HSPD1 EPPK1 DNAJB4 LAP3 EEF1A2 FASN	4.81e-05	152	147	6	16009940
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	5.31e-05	3	147	2	31645370
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	5.31e-05	3	147	2	11960914
Pubmed	Nodal and lefty signaling regulates the growth of pancreatic cells.	LEFTY2 LEFTY1	5.31e-05	3	147	2	18393305
Pubmed	Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.	LEFTY2 LEFTY1	5.31e-05	3	147	2	32065356
Pubmed	Role of asymmetric signals in left-right patterning in the mouse.	LEFTY2 LEFTY1	5.31e-05	3	147	2	11471154
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	5.31e-05	3	147	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	5.31e-05	3	147	2	8188299
Pubmed	Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.	LEFTY2 LEFTY1	5.31e-05	3	147	2	16141390
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRS	5.31e-05	3	147	2	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRS	5.31e-05	3	147	2	20139422
Pubmed	IFT46 plays an essential role in cilia development.	LEFTY2 LEFTY1	5.31e-05	3	147	2	25722189
Pubmed	Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.	LEFTY2 LEFTY1	5.31e-05	3	147	2	10886363
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	5.31e-05	3	147	2	8250953
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRS	5.31e-05	3	147	2	33656439
Pubmed	Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.	LEFTY2 LEFTY1	5.31e-05	3	147	2	37097539
Pubmed	Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.	ESRRB ESRRG	5.31e-05	3	147	2	29888756
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	5.31e-05	3	147	2	2703500
Pubmed	Adenosine A2A receptor and vascular response: role of soluble epoxide hydrolase, adenosine A1 receptor and angiotensin-II.	EPHX2 ADORA1	5.31e-05	3	147	2	33511551
Pubmed	The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins.	RPH3A CASK	5.31e-05	3	147	2	11377421
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	5.31e-05	3	147	2	22217847
Pubmed	Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.	LEFTY2 LEFTY1	5.31e-05	3	147	2	26316705
Pubmed	Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.	ESRRB ESRRG	5.31e-05	3	147	2	15598686
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	5.31e-05	3	147	2	22890016
Cytoband	1q42.1	LBR LEFTY2 LEFTY1	6.93e-06	12	147	3	1q42.1
GeneFamily	Fibronectin type III domain containing	COL12A1 OBSCN ITGB4 PTPRD PTPRS LRIT1	3.42e-04	160	105	6	555
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ANKRD42 SLC7A14 NCOR1 SH2D4A TRIM28 YLPM1	6.57e-04	181	105	6	694
GeneFamily	Sterile alpha motif domain containing	INPPL1 SAMD7 SHANK2 SAMD3	1.72e-03	88	105	4	760
GeneFamily	PDZ domain containing	MPP2 PDZD7 CASK SHANK2 SIPA1L1	1.93e-03	152	105	5	1220
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN PTPRD HMCN1 PTPRS LRIT1	2.48e-03	161	105	5	593
GeneFamily	Helix-turn-helix CENPB type domain containing	TIGD7 POGK	2.50e-03	13	105	2	533
GeneFamily	Nuclear hormone receptors	ESRRB ESRRG NR1D1	2.89e-03	49	105	3	71
GeneFamily	Olfactory receptors, family 52	OR52P1 OR52R1 OR52M1	2.89e-03	49	105	3	165
GeneFamily	Chaperonins	HSPD1 CCT7	3.34e-03	15	105	2	587
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	EP400 GON4L NCOR1	3.61e-03	53	105	3	532
GeneFamily	Parkinson disease associated genes	PARK7 ATP13A2	3.80e-03	16	105	2	672
GeneFamily	T-boxes	TBX19 TBX20	4.81e-03	18	105	2	766
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRS	6.53e-03	21	105	2	813
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 OBSCN ARHGEF40	6.68e-03	66	105	3	722
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHX2 SMARCAL1 CGAS USP43 DNAJB4 EML3 ALDH4A1 VCPIP1	1.37e-07	177	147	8	164ffbbf798defa3728197deb1a14b661490e525
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG LRP1B ABLIM1 SHANK2 HMCN1 KCNJ10	1.84e-07	184	147	8	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	TRMT9B ESRRB ESRRG LRP1B ABLIM1 HMCN1 KCNJ10 ARNT2	2.17e-07	188	147	8	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	EPHX2 USP28 DYNLT2 P2RY11 TXNL4B KLHL42 SARDH	2.07e-06	177	147	7	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESRRB PDZD7 LRP1B NCCRP1 SH2D4A KCNJ10 AK1	3.32e-06	190	147	7	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESRRB PDZD7 LRP1B NCCRP1 SH2D4A KCNJ10 AK1	3.32e-06	190	147	7	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG CASK ABLIM1 KCNJ10 PADI2 CHAC1	4.07e-06	196	147	7	1bfc3c85ce9501f52a912e53cbded7de74572b9d
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG CASK ABLIM1 KCNJ10 PADI2 CHAC1	4.07e-06	196	147	7	e02301642243df483fd066d978317c113c04692b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RYR2 LEFTY2 LEFTY1 PTPRD HMCN1 PTPRS NID1	4.21e-06	197	147	7	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	OBSCN GABBR2 RYR2 EEF1A2 ABLIM1 FASN GNAZ	4.65e-06	200	147	7	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	OBSCN GABBR2 RYR2 EEF1A2 ABLIM1 FASN GNAZ	4.65e-06	200	147	7	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	GABBR2 RPH3A RYR2 GREB1L SLC4A10 SAMD3	1.71e-05	163	147	6	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG USP43 HMCN1 KCNJ10	2.39e-05	173	147	6	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FMO3 RYR2 LEFTY1 PTPRD HMCN1 PTPRS	2.72e-05	177	147	6	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FMO3 RYR2 LEFTY1 PTPRD HMCN1 PTPRS	2.72e-05	177	147	6	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_naive-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HSPD1 EPHX2 RBL2 RPS14 ABLIM1 DDX18	2.72e-05	177	147	6	db6de487ef7976b444afadbf3ac60b3259925566
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPRC1 DNAH2 SLC28A3 SAMD7 C22orf23 CCDC180	2.81e-05	178	147	6	6178706db4a855d72abc156537604d575624df56
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPRC1 DNAH2 SLC28A3 SAMD7 C22orf23 CCDC180	2.81e-05	178	147	6	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ARHGAP40 LRP1B PTPRD SHANK2	2.81e-05	178	147	6	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK2 OBSCN LENEP RYR2 EEF1A2 AK1	3.08e-05	181	147	6	09a574a3257e25c8b05a2ab20623a6b07331411a
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK2 OBSCN LENEP RYR2 EEF1A2 AK1	3.08e-05	181	147	6	ac4142aa93706b7067f63d2d38e2456859e60768
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK2 OBSCN RYR2 FN3K EEF1A2 AK1	3.18e-05	182	147	6	c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK2 OBSCN RYR2 FN3K EEF1A2 AK1	3.18e-05	182	147	6	c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN LRP1B RYR2 PTPRD HMCN1	3.38e-05	184	147	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN LRP1B RYR2 PTPRD HMCN1	3.38e-05	184	147	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN LRP1B RYR2 PTPRD HMCN1	3.38e-05	184	147	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FMO3 ARHGAP40 RASGRF1 SH2D4A CCDC180	3.52e-05	112	147	5	456278fb92dd41820fde8cf27c68fec45e15f972
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG LRP1B KCNJ10 PADI2	3.70e-05	187	147	6	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHX2 ESRRB ESRRG LRP1B ARNT2 PADI2	3.70e-05	187	147	6	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 ESRRG RPH3A RYR2 EEF1A2 SAMD3	3.70e-05	187	147	6	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRMT9B ESRRB ESRRG LRP1B KCNJ10 ARNT2	3.81e-05	188	147	6	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG LRP1B HMCN1 KCNJ10 ARNT2	3.93e-05	189	147	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG LRP1B ABLIM1 ARNT2	4.04e-05	190	147	6	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG LRP1B ABLIM1 ARNT2	4.04e-05	190	147	6	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRMT9B ITGB4 ABLIM1 HMCN1 SHE GNAZ	4.04e-05	190	147	6	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG LRP1B ABLIM1 SHANK2 ARNT2	4.04e-05	190	147	6	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG LRP1B ABLIM1 SHANK2 ARNT2	4.16e-05	191	147	6	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ESRRB ESRRG LRP1B ABLIM1 ARNT2	4.16e-05	191	147	6	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	USP28 ESRRG OBSCN RYR2 GREB1L ABLIM1	4.16e-05	191	147	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ARHGAP40 XDH PTPRD SHANK2	4.16e-05	191	147	6	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 TRMT9B ESRRB ESRRG ABLIM1 ARNT2	4.16e-05	191	147	6	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 TRMT9B ESRRB ESRRG ABLIM1 ARNT2	4.16e-05	191	147	6	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG LRP1B ABLIM1 KCNJ10 ARNT2	4.29e-05	192	147	6	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ARHGAP40 XDH PTPRD SHANK2	4.41e-05	193	147	6	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP1B ITGB4 ADORA1 ABLIM1 HMCN1 SHE	4.41e-05	193	147	6	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	USP28 ESRRG OBSCN RYR2 GREB1L ABLIM1	4.54e-05	194	147	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ARHGAP40 XDH PTPRD SHANK2	4.67e-05	195	147	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAJB4 RYR2 PTPRD HMCN1 PTPRS NID1	4.95e-05	197	147	6	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	COL12A1 LARP6 LRP1B PTPRD PTPRS NID1	4.95e-05	197	147	6	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK1 LARP6 RASGRF1 SLC7A14 PTPRD KCNJ10	4.95e-05	197	147	6	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	COL12A1 LARP6 LRP1B PTPRD PTPRS NID1	4.95e-05	197	147	6	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	COL12A1 LARP6 LRP1B PTPRD PTPRS NID1	4.95e-05	197	147	6	5b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ESRRG XDH SLC28A3 ITGB4 SHANK2 PADI2	5.38e-05	200	147	6	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FMO3 RYR2 PTPRD HMCN1 PTPRS NID1	5.38e-05	200	147	6	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FMO3 RYR2 PTPRD HMCN1 PTPRS NID1	5.38e-05	200	147	6	a510deaada669e690329183e18df02870bd204b3
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP40 ESRRG XDH SLC28A3 SHANK2 PADI2	5.38e-05	200	147	6	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FMO3 RYR2 PTPRD HMCN1 PTPRS NID1	5.38e-05	200	147	6	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ADORA1 C22orf23 MICAL2 SAMD3	1.32e-04	148	147	5	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ADORA1 C22orf23 MICAL2 SAMD3	1.32e-04	148	147	5	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 ADORA1 C22orf23 MICAL2 SAMD3	1.32e-04	148	147	5	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	HSPD1 LRP1B TUFM ZFR2 CCDC180	1.50e-04	152	147	5	bffbbdf1047c59e5241c99dc10b36cfe2071aa48
ToppCell	VE-CD8-memory_CD4\|VE / Condition, Cell_class and T cell subcluster	USP43 GREB1L FASN HMCN1 SAMD3	1.50e-04	152	147	5	9401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EP400 DNAJC27 SLC28A3 JARID2 CC2D2A	1.74e-04	157	147	5	d8e283414a770f05d71f0455d0822e9a9660b115
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EP400 DNAJC27 SLC28A3 JARID2 CC2D2A	1.74e-04	157	147	5	165e98bf944572cafbc06ef43c9eab7bd6bea1c2
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POGK USP43 P2RY11 GUCY2D ASIC4	1.79e-04	158	147	5	2ae863ccef201414b82a2ecf7cf1bbb1b0ce4a3c
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GABBR2 RPH3A RYR2 GREB1L SLC4A10	1.85e-04	159	147	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ESRRG LRP1B RYR2 HMCN1	1.90e-04	160	147	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ESRRG LRP1B RYR2 HMCN1	1.90e-04	160	147	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACAT2 ESRRB ESRRG LRP1B HMCN1	1.96e-04	161	147	5	4bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ARHGAP40 GREB1L SHANK2	2.01e-04	162	147	5	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 FMO3 TBX19 MICAL2 SAMD3	2.07e-04	163	147	5	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 FMO3 TBX19 MICAL2 SAMD3	2.07e-04	163	147	5	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	droplet-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD42 XDH NR1D1 MEFV HMCN1	2.25e-04	166	147	5	e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ENTPD4 LAP3 GRHPR SARDH	2.25e-04	166	147	5	8ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCell	droplet-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD42 XDH NR1D1 MEFV HMCN1	2.25e-04	166	147	5	3ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRF1 DNAH2 GABBR2 RPH3A SLC4A10	2.32e-04	167	147	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 COL12A1 SLC28A3 ARHGEF40 MICAL2	2.32e-04	167	147	5	805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 COL12A1 SLC28A3 ARHGEF40 MICAL2	2.32e-04	167	147	5	31cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 COL12A1 SLC28A3 ARHGEF40 MICAL2	2.32e-04	167	147	5	3acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	OBSCN DYNLT2 PDZD7 TBX19 TRNAU1AP	2.38e-04	168	147	5	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBL2 ABLIM1 WDR6 SARDH PADI2	2.38e-04	168	147	5	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	B4GALT2 DOCK1 FN3K PTPRS CC2D2A	2.38e-04	168	147	5	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP40 ARHGEF40 GUCY2D AK1 ASIC4	2.38e-04	168	147	5	a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FASN P2RY11 MICAL2 NID1 ASIC4	2.58e-04	171	147	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ENTPD4 LAP3 GRHPR SARDH	2.58e-04	171	147	5	48fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGB4 LEFTY1 HMCN1 ARNT2 SHE	2.58e-04	171	147	5	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	droplet-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XDH SLC28A3 ITGB4 SH2D4A SARDH	2.58e-04	171	147	5	92ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCell	droplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 ENTPD4 LAP3 GRHPR SARDH	2.58e-04	171	147	5	05fcc72df50a380a913821b5781d9621df37d328
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FASN P2RY11 MICAL2 NID1 ASIC4	2.58e-04	171	147	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPD1 EPHX2 LAP3 GRHPR HSD17B4	2.66e-04	172	147	5	feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPD1 EPHX2 LAP3 GRHPR HSD17B4	2.66e-04	172	147	5	9adfb4a65669cc536343616637058d0a4728013f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPD1 EPHX2 LAP3 GRHPR HSD17B4	2.66e-04	172	147	5	8aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP28 NR1D1 CFAP65 ARHGEF40 MAPKAPK3	2.66e-04	172	147	5	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	droplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CFAP65 LEFTY1 PTPRS PADI2	2.73e-04	173	147	5	8fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRB ESRRG CASK ABLIM1 ARNT2	2.73e-04	173	147	5	7a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCell	droplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CFAP65 LEFTY1 PTPRS PADI2	2.73e-04	173	147	5	f663571aaae2365660a8b526c355f4bd1a124a74
ToppCell	AT1-AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 COL12A1 ABLIM1 MICAL2 ARNT2	2.88e-04	175	147	5	9a95ab5c361ebaa8747983c5a0d69025682a19ad
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO3 RASGRF1 INPPL1 ESRRG GABBR2	2.88e-04	175	147	5	0992de1c7bffcb6890584357a7a0a8955927da6c
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 OBSCN LEFTY1 PTPRS PADI2	2.95e-04	176	147	5	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 OBSCN LEFTY1 PTPRS PADI2	2.95e-04	176	147	5	31b5459a978d5cdde0af03a77401e0464d8c95ba
Drug	3-Acetamidocoumarin [779-30-6]; Up 200; 19.6uM; MCF7; HT_HG-U133A	LONP2 PDK2 RPS14 GON4L ITGB4 SIPA1L1 AK1 ALDH4A1 PADI2	4.59e-06	195	145	9	7361_UP
Drug	radicicol; Down 200; 0.1uM; SKMEL5; HG-U133A	RASGRF1 ABLIM1 SH2D4A TRNAU1AP MICAL2 AK1 NID1 ALDH4A1 POFUT2	4.98e-06	197	145	9	493_DN
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; HL60; HT_HG-U133A	CRYBG2 EML2 GABBR2 ATP13A2 ABLIM1 SH2D4A YLPM1 NID1 SARDH	5.19e-06	198	145	9	2492_UP
Drug	Quinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A	MPP2 TRMT9B TAF1C RPS14 GON4L ENTPD4 TBX19 SH2D4A YLPM1	5.19e-06	198	145	9	6019_DN
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; MCF7; HT_HG-U133A	DOCK1 MPP2 PDK2 RPS14 NR1D1 EML3 TBX19 NCOR1 AK1	5.41e-06	199	145	9	5496_DN
Drug	fullerene C60	B4GALT2 FMO3 LARP6 RASGRF1 PPRC1 INPPL1 NLRX1 XDH SLC28A3 CCT7 PDZD7 NR1D1 ATP13A2 EEF1A2 ADORA1 NCOR1 TRIM28 WDR6 MAPKAPK3 OTOP1 KLHL42 ARHGAP25 ALDH4A1 ASIC4 MED13	8.47e-06	1498	145	25	ctd:C069837
Drug	hydroxyl radicals	EPHX2 CYP2A6 CYP2A7 FMO3 PDK2 USP28 INPPL1 XDH LBR LRP1B ENTPD4 LAP3 TUFM EEF1A2 FASN PTPRD PTPRS FLAD1 AK1 ALDH4A1 SARDH HSD17B4 PADI2	1.32e-05	1341	145	23	CID000000961
Drug	mono-(2-ethylhexyl)phthalate	EPHX2 COL12A1 FMO3 GABBR2 ITGB4 RPH3A ADORA1 JARID2 NCOR1 FASN PTPRD WDR6 MAPKAPK3 SLC4A10 HSD17B4	2.07e-05	658	145	15	ctd:C016599
Drug	MCDF	PPRC1 ESRRB ESRRG ARNT2	2.87e-05	28	145	4	CID000114900
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	LONP2 NLRX1 RPS14 XDH EML2 ENTPD4 EML3 YLPM1	3.41e-05	193	145	8	1657_UP
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	EPHX2 CRYBG2 ITGB4 ARHGEF40 PTPRS MICAL2 ALDH4A1 CHAC1	3.81e-05	196	145	8	6785_UP
Drug	phenformin hydrochloride; Up 200; 10uM; MCF7; HG-U133A	PDK2 ZC3H13 NLRX1 ITGB4 GREB1L ABLIM1 YLPM1 ALDH4A1	3.95e-05	197	145	8	21_UP
Drug	Azathioprine [446-86-6]; Up 200; 14.4uM; MCF7; HT_HG-U133A	CRYBG2 KMT2B NR1D1 ENTPD4 PTPRD AK1 CHAC1 VCPIP1	3.95e-05	197	145	8	1528_UP
Drug	Nitrocaramiphen hydrochloride; Up 200; 10.8uM; MCF7; HT_HG-U133A	MPP2 LONP2 XDH ITGB4 RYR2 TBX19 SH2D4A VCPIP1	3.95e-05	197	145	8	7464_UP
Drug	Promethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	MPP2 LARP6 EML2 GABBR2 ENTPD4 RYR2 ALDH4A1 CHAC1	3.95e-05	197	145	8	5317_UP
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	LONP2 PDK2 GON4L RYR2 TBX19 NCOR1 MICAL2 ALDH4A1	3.95e-05	197	145	8	3308_DN
Drug	N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide	ESRRB ESRRG	4.03e-05	2	145	2	ctd:C501618
Drug	Betahistine mesylate [54856-23-4]; Up 200; 17.2uM; HL60; HT_HG-U133A	CRYBG2 EML2 GABBR2 ATP13A2 ADORA1 ABLIM1 SIPA1L1 ALDH4A1	4.09e-05	198	145	8	2472_UP
Disease	azoospermia (implicated_via_orthology)	ESRRB ESRRG PTPRD PTPRS	7.39e-06	27	138	4	DOID:14227 (implicated_via_orthology)
Disease	Nicotine dependence	CYP2A6 GABBR2	1.29e-04	4	138	2	cv:C0028043
Disease	Tobacco addiction, susceptibility to	CYP2A6 GABBR2	1.29e-04	4	138	2	cv:C1861063
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO	CYP2A6 GABBR2	1.29e-04	4	138	2	188890
Disease	Hypertrophic Cardiomyopathy	HSPD1 OBSCN RYR2 FASN	1.49e-04	57	138	4	C0007194
Disease	retinal layer thickness measurement	ADORA1 NBAS PTPRD PIK3C2A	1.82e-04	60	138	4	EFO_0600002
Disease	R-6-hydroxywarfarin measurement	DNAH2 SLC28A3 LRP1B PTPRD SHANK2	2.03e-04	114	138	5	EFO_0803327
Disease	response to TNF antagonist, joint damage measurement	DOCK1 MPP2 GABBR2	2.13e-04	25	138	3	EFO_0004653, EFO_0005413
Disease	forced expiratory volume, response to bronchodilator	MPP2 CYP2A6 CYP2A7 EPPK1 ESRRG LRP1B PTPRD SHANK2 ARNT2	2.57e-04	445	138	9	EFO_0004314, GO_0097366
Disease	severe acute respiratory syndrome, COVID-19	TRMT9B LRP1B CASK JARID2 ABLIM1 PTPRD ARNT2 SLC4A10 ADGRF3	2.66e-04	447	138	9	EFO_0000694, MONDO_0100096
Disease	cerebral infarction (implicated_via_orthology)	EPHX2 ADORA1	3.22e-04	6	138	2	DOID:3526 (implicated_via_orthology)
Disease	Middle Cerebral Artery Embolus	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0751845
Disease	Embolic Infarction, Middle Cerebral Artery	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0751847
Disease	Left Middle Cerebral Artery Infarction	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0751846
Disease	Right Middle Cerebral Artery Infarction	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0751849
Disease	Thrombotic Infarction, Middle Cerebral Artery	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0751848
Disease	Middle Cerebral Artery Occlusion	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0740391
Disease	Infarction, Middle Cerebral Artery	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0740392
Disease	Middle Cerebral Artery Thrombosis	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0740376
Disease	Middle Cerebral Artery Syndrome	HSPD1 XDH ADORA1	5.39e-04	34	138	3	C0238281
Disease	PR interval	CRYBG2 USP28 OBSCN RYR2 ARHGEF40 MICAL2 SIPA1L1 SAMD3 TBX20	5.56e-04	495	138	9	EFO_0004462
Disease	longitudinal BMI measurement	DOCK1 MPP2 SLC28A3 PTPRD	6.04e-04	82	138	4	EFO_0005937
Disease	resting heart rate	EPPK1 ARHGEF40 MICAL2 KLHL42 TBX20	6.94e-04	149	138	5	EFO_0004351
Disease	Nephroblastoma	MPP2 NBAS	9.53e-04	10	138	2	Orphanet_654
Disease	beta-nerve growth factor measurement	RPH3A TBX19 FASN	1.01e-03	42	138	3	EFO_0008035
Disease	autistic disorder (is_implicated_in)	HSPD1 JARID2 SHANK2	1.01e-03	42	138	3	DOID:12849 (is_implicated_in)
Disease	smoking status measurement	EPHX2 CYP2A6 ESRRG DNAJB4 DNAJC27 SLC28A3 PDZD7 GABBR2 RPH3A RYR2 PTPRD SLC4A10 HSD17B12 CC2D2A	1.11e-03	1160	138	14	EFO_0006527
Disease	lung adenocarcinoma	TRMT9B EPHX2 CYP2A6 DNAJB4 MICAL2	1.39e-03	174	138	5	EFO_0000571
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	1.39e-03	12	138	2	EFO_0007794
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	CYP2A6 GABBR2	1.39e-03	12	138	2	C1861063
Disease	salicylurate measurement	RYR2 ABLIM1	1.64e-03	13	138	2	EFO_0010532
Disease	Modic type vertebral endplate changes	MPP2 PTPRD	1.64e-03	13	138	2	HP_0030775
Disease	Congestive heart failure	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C0018802
Disease	Heart failure	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C0018801
Disease	Left-Sided Heart Failure	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C0023212
Disease	Heart Failure, Right-Sided	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C0235527
Disease	Heart Decompensation	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C1961112
Disease	Myocardial Failure	EPHX2 XDH FASN TBX20	1.80e-03	110	138	4	C1959583
Disease	inherited metabolic disorder (is_implicated_in)	FMO3 TBX19	2.19e-03	15	138	2	DOID:655 (is_implicated_in)
Disease	body weight	DOCK1 MPP2 RASGRF1 PARK7 ESRRG DNAJB4 GON4L SLC28A3 LRP1B RPH3A NBAS NCOR1 FASN HSD17B12	2.40e-03	1261	138	14	EFO_0004338
Disease	hypertension (is_implicated_in)	EPHX2 FMO3 INPPL1 XDH	2.55e-03	121	138	4	DOID:10763 (is_implicated_in)
Disease	response to radiation, Urinary retention	LRP1B PTPRS	2.82e-03	17	138	2	GO_0009314, HP_0000016
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B MED13	2.82e-03	17	138	2	DOID:0060307 (is_implicated_in)
Disease	Cannabis use, age at onset	SLC28A3 RYR2	3.52e-03	19	138	2	EFO_0004847, EFO_0007585
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	3.52e-03	19	138	2	EFO_0007872
Disease	exercise test	RYR2 PTPRD	3.90e-03	20	138	2	EFO_0004328
Disease	susceptibility to mononucleosis measurement	DNAH2 RYR2 PTPRD	4.19e-03	69	138	3	EFO_0008403
Disease	Profound Mental Retardation	GON4L FASN SHANK2 SLC4A10	4.19e-03	139	138	4	C0020796
Disease	Mental Retardation, Psychosocial	GON4L FASN SHANK2 SLC4A10	4.19e-03	139	138	4	C0025363
Disease	Mental deficiency	GON4L FASN SHANK2 SLC4A10	4.19e-03	139	138	4	C0917816
Disease	cardiomyopathy (implicated_via_orthology)	XDH RPH3A TBX20	4.54e-03	71	138	3	DOID:0050700 (implicated_via_orthology)
Disease	cigarettes per day measurement	EPHX2 CYP2A6 CYP2A7 DNAJC27 PTPRD SIPA1L1 HSD17B12	4.65e-03	438	138	7	EFO_0006525

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGMAEQSKRPRLEVG	EP400	511	Q96L91
LTGMKISRPDIRIGR	B4GALT2	291	O60909
TPGLVLVISIMAGDR	ADGRF3	681	Q8IZF5
GVGTPRMERKRSISA	ARHGEF40	1071	Q8TER5
RFGDVIPMSLARRVK	CYP2A6	361	P11509
AVVGPDMKRRSSGRE	ABLIM1	576	O14639
KMVVTPRRAAVAIAG	ADORA1	116	P30542
SAKAGVIFPVGRMLR	MACROH2A1	16	O75367
SGPRRAEILAKTMVG	ALDH4A1	136	P30038
ISKGANPVEIRRGVM	HSPD1	131	P10809
AAERSVTLKSGRIPM	CCDC180	81	Q9P1Z9
EAGVKLGMRSIPIAT	CCNQ	36	Q8N1B3
VIMKRKRGGSPAVTL	CGAS	296	Q8N884
IMLRSGVDPSVTDKR	ANKRD42	116	Q8N9B4
ITTMRKRFRNGLGPV	ARNT2	256	Q9HBZ2
MPSRKFADGEVVRGR	LBR	1	Q14739
MIRTGETPTKKRGIL	RBL2	1091	Q08999
RKGMTGRPTRTLIEF	LAP3	496	P28838
LREMRGSITFKIVPS	CASK	556	O14936
QMEVVTKGTGFRRRP	C22orf23	6	Q9BZE7
AVLRSPGMTVAEKLR	P2RY11	231	Q96G91
DRSLKPMQTRVVGRL	FMO3	491	P31513
AMTGEITLRGLVLPV	LONP2	766	Q86WA8
MIVSIKEGGRTRPQV	LEFTY1	326	O75610
RPGIVRGMDLNTKIA	LRP1B	531	Q9NZR2
TGQAISPGMKRRIRL	MAPKAPK3	246	Q16644
MGPGIRRRRVLTKDG	KCNJ10	21	P78508
RDTGLRVPVIKMGTG	LENEP	21	Q9Y5L5
RKVRDGPRVTAVIMV	GUCY2D	231	Q02846
SIPVGISLGLLKREM	INTS11	451	Q5TA45
PGRSLRIKVISMGNA	DNAJC27	11	Q9NZQ0
GPETMTQRLLKRGET	AK1	121	P00568
TIRPAFGTLVGKARM	CFAP65	511	Q6ZU64
ENRTIGATMVRLVKP	BMP15	86	O95972
KNRMEPGGLRRTRVT	NCCRP1	251	Q6ZVX7
GVVDIPFRSKGMSRL	EXD2	286	Q9NVH0
GEPRVGKTSLIMSLV	RHOT1	11	Q8IXI2
RGMVELVPASDTLRK	PIK3C2A	1181	O00443
MRRAGIKVTVAGLAG	PARK7	26	Q99497
RGIRASSPMGRVILI	PDZD7	56	Q9H5P4
SAIMPGSEKIRRLVE	NEK4	766	P51957
TGKIERLPLEGNTMR	NID1	951	P14543
RKMQTADGLPVGVLR	LARP6	456	Q9BRS8
FSRVRMKTPTVRGVL	KMT2B	2321	Q9UMN6
GKMRPRSLEVTISTG	MEFV	236	O15553
LRGIMESPIVRSLAK	MPP2	36	Q14168
GKEISMVRIPNRGSA	ASIC4	381	Q96FT7
REDLRRGLVMVKPGS	TUFM	331	P49411
IKVVPRVFGRMVGKS	NLRX1	556	Q86UT6
RRTGAVPKQRGMLIL	POGK	456	Q9P215
IGVAAVVRGSLLMLP	OR52P1	146	Q8NH57
PLSGGRRMTKVVRDF	PADI2	436	Q9Y2J8
IVKLRFMPRNGTGVL	DDX18	241	Q9NVP1
GTGVLILSPTRELAM	DDX18	251	Q9NVP1
KSGRGHMLIIRVPSV	GREB1L	951	Q9C091
TPMLRSGNLKGRDVV	ITGB4	776	P16144
DGVTAVPKTLGLLRM	NBAS	291	A2RRP1
GRAGPSEARMVRSVK	LRIT1	421	Q9P2V4
IKMSDRGGGVPLRKI	PDK2	286	Q15119
PVLTDSMGRVRILSG	HMCN1	2236	Q96RW7
IVMVPLRKSRGGQFL	PTPRS	1156	Q13332
MVAEGPVRSLTVLGL	OBSCN	1856	Q5VST9
PSVVIKLGTIVMLRG	OR52R1	141	Q8NGF1
VGMSRDAVRFGRIPK	NR1D1	196	P20393
RGGVRASVPQKLAEM	OTOP1	46	Q7RTM1
VLMSRTGPALVLGRV	ATP13A2	976	Q9NQ11
VNDIVKPGMRRRIIG	DNAJB4	281	Q9UDY4
KAVESMPRGVVVTLR	HECTD1	846	Q9ULT8
PEGATTRLMKGEITL	EPHX2	46	P34913
SKGEITPELLGVMRR	GNAZ	116	P19086
EEPKTRLLSMTVRRG	CC2D2A	66	Q9P2K1
KLTSGLRRPFGVAVM	DOCK1	316	Q14185
MRPRARKIGVLITDG	COL12A1	1296	Q99715
RFGDVIPMSLARRVK	CYP2A7	361	P20853
MGSPLRFDGRVVLVT	HSD17B4	1	P51659
RVETGILRPGMVVTF	EEF1A2	266	Q05639
VGMLKEGVRLDRVRG	ESRRG	191	P62508
HRGSDKMPGRVVTLL	CHAC1	71	Q9BUX1
GPMARAKARVVSATL	CRYBG2	6	Q8N1P7
LMKVFVTRRIPAEGR	GRHPR	6	Q9UBQ7
VRTTRKGEMPVSAGL	GON4L	1936	Q3T8J9
LVLPGMVERSKGAIL	HSD17B12	171	Q53GQ0
TASLPMIVSIKEGGR	LEFTY2	321	O00292
MIVSIKEGGRTRPQV	LEFTY2	326	O00292
LMPLTKEVAKGSIGR	GABBR2	61	O75899
VEDGSVKMFLRGRPV	EML2	16	O95834
LEGISVKMFLRGRPI	EML3	211	Q32P44
VGMLKEGVRLDRVRG	ESRRB	166	O95718
KRVMGLVPAKGLATS	FASN	1611	P49327
GIPELLRRVLEGMKG	FLAD1	256	Q8NFF5
RIGGRLLMRIGDKEV	DNAH2	3461	Q9P225
PFLGRIEIMGSAKRI	RYR2	4131	Q92736
ERRVVFIGKIPGRMT	PPRC1	1541	Q5VV67
FIGKIPGRMTRSELK	PPRC1	1546	Q5VV67
MKQERRVSGIGKPVL	MICAL2	736	O94851
GPQLKVVERTRTATM	PTPRD	131	P23468
GAGVTSAKKMREVRP	JARID2	316	Q92833
ILVAIMKVPSAGGRK	OR1M1	221	Q8NGA1
RAVMGLATPEARLKT	OR52M1	226	Q8NGK5
MSVKIIRNRLTGIPA	TRNAU1AP	31	Q9NX07
LERVIPMKRAGTTGS	RPH3A	516	Q9Y2J0
MDAILKAVGIRTKPG	TMCO4	511	Q5TGY1
QDTIIPKGIERGSMR	SAMD7	431	Q7Z3H4
LKERMEGRPLRTTVF	LIPI	311	Q6XZB0
VPSLEGAVRKIRSLM	POFUT2	306	Q9Y2G5
QTLEIRRKMIGSRTP	SAMD3	311	Q8N6K7
HPRVLTVGDRTGVKM	TAF1C	396	Q15572
LTPGDRVMLIGTTSR	IQCA1L	661	A6NCM1
IVRKRTAGILDMGGV	ENTPD4	261	Q9Y227
GIPTEALVKGSISRM	NCOR1	1176	O75376
TMEVKVGRLRGRAVP	EPPK1	2521	P58107
ALRSTGLVRVPRPMK	FN3K	61	Q9H479
VAKRVILLSGTPAMS	SMARCAL1	571	Q9NZC9
RSGMKIGRIEDVTPI	RPS14	121	P62263
TSTPGVPKMGVRARI	SIPA1L1	66	O43166
IRGSMKVRVPTERLG	INPPL1	866	O15357
VIAEAVRTTLGPRGM	CCT7	31	Q99832
VRTTLGPRGMDKLIV	CCT7	36	Q99832
RAMKVRGAPAIALVG	MRI1	41	Q9BV20
GTGTTLDPMRLQKIR	SWSAP1	51	Q6NVH7
IVIGGLTSMAPSRKR	SLC28A3	571	Q9HAS3
PVSRLLTDGIMRVGS	MED13	1406	Q9UHV7
VPMSEKGKITRGRLG	RASGRF1	466	Q13972
SAVGRMAGVKVPLVA	SARDH	276	Q9UL12
FLGIPRGTMRRQKSI	SHANK2	836	Q9UPX8
ILRTKPVESMLEGTG	SLC7A14	26	Q8TBB6
AARKTTGIRKGISPM	FYTTD1	106	Q96QD9
LVRGVKGRSISMKAP	USP43	786	Q70EL4
RVLKGVMRVGILAKG	ZFR2	651	Q9UPR6
MEGILRVPGSQARVK	ARHGAP40	306	Q5TG30
LRTGVKIGEMPLTDS	ACAT2	131	Q9BWD1
IRSKVEDPAVIMRGT	ARHGAP25	321	P42331
PKFLGIREQRVTGLM	SLC4A10	901	Q6U841
MPGSFLIRVSERIKG	SH2D4A	366	Q9H788
IAKVTSGMRVLFKPG	XDH	431	P47989
STPAGVQVILRRMLK	MRPL34	71	Q9BQ48
LLMKGPRRGVKESVI	USP28	931	Q96RU2
LIRIAPGVVTMRDGR	VCPIP1	1081	Q96JH7
LAGLRIVPDGSMVIL	WDR6	616	Q9NNW5
ITAVKDMPVRSGGLL	YLPM1	731	P49750
IRAIKEMARVLVPGG	TRMT9B	121	Q9P272
IITKSGRRMFPTIRV	TBX20	121	Q9UMR3
ERKEPGMVVREGTRR	ZFP14	61	Q9HCL3
RGAMRGKLIVQSPID	TXNL4B	121	Q9NX01
NGRRMFPVLKISVTG	TBX19	66	O60806
QMITEIRRRGSKDPL	SHE	236	Q5VZ18
MPLVGAEKRKRTTGA	TIGD7	61	Q6NT04
FTPGAVMLRVGISKK	ZC3H13	1521	Q5T200
GEVSGLMRKVPRVSL	TRIM28	476	Q13263
MEKRGRGVKSSPIQT	DYNLT2	1	Q8IZS6
LKQRLREARMTGTPV	KLHL42	181	Q9P2K6
REARMTGTPVLVALG	KLHL42	186	Q9P2K6