Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenosine deaminase activity	ZBP1 ADA2	2.86e-04	13	39	2	GO:0004000
GeneOntologyMolecularFunction	double-stranded RNA binding	ZBP1 AGO3 DHX30	4.74e-04	78	39	3	GO:0003725
GeneOntologyMolecularFunction	chromatin binding	NCOA2 CHD1 SATB2 ATRX USP51 ATXN7 DHX30	5.05e-04	739	39	7	GO:0003682
GeneOntologyBiologicalProcess	post-embryonic forelimb morphogenesis	VPS54 ATRX	9.38e-06	3	37	2	GO:0035128
GeneOntologyBiologicalProcess	post-embryonic limb morphogenesis	VPS54 ATRX	3.12e-05	5	37	2	GO:0035127
GeneOntologyBiologicalProcess	post-embryonic appendage morphogenesis	VPS54 ATRX	3.12e-05	5	37	2	GO:0035120
GeneOntologyBiologicalProcess	post-embryonic animal morphogenesis	VPS54 ATRX	1.40e-04	10	37	2	GO:0009886
GeneOntologyCellularComponent	keratohyalin granule	FLG FLG2	3.21e-05	5	38	2	GO:0036457
Domain	Filaggrin	FLG FLG2	4.25e-06	2	39	2	IPR003303
Domain	dsrm	DROSHA DHX30	7.88e-04	20	39	2	PF00035
Domain	DS_RBD	DROSHA DHX30	8.70e-04	21	39	2	PS50137
Domain	Helicase_C	CHD1 ATRX DHX30	1.44e-03	107	39	3	PF00271
Domain	HELICc	CHD1 ATRX DHX30	1.44e-03	107	39	3	SM00490
Domain	S100_CABP	FLG FLG2	1.44e-03	27	39	2	PS00303
Domain	S_100	FLG FLG2	1.44e-03	27	39	2	PF01023
Domain	Helicase_C	CHD1 ATRX DHX30	1.48e-03	108	39	3	IPR001650
Domain	HELICASE_CTER	CHD1 ATRX DHX30	1.52e-03	109	39	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD1 ATRX DHX30	1.52e-03	109	39	3	PS51192
Domain	DEXDc	CHD1 ATRX DHX30	1.52e-03	109	39	3	SM00487
Domain	S100_Ca-bd_sub	FLG FLG2	1.55e-03	28	39	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG FLG2	1.55e-03	28	39	2	IPR001751
Domain	S_100	FLG FLG2	1.55e-03	28	39	2	SM01394
Domain	Helicase_ATP-bd	CHD1 ATRX DHX30	1.56e-03	110	39	3	IPR014001
Domain	SNF2_N	CHD1 ATRX	2.03e-03	32	39	2	PF00176
Domain	SNF2_N	CHD1 ATRX	2.03e-03	32	39	2	IPR000330
Domain	DNA/RNA_helicase_DEAH_CS	CHD1 DHX30	2.42e-03	35	39	2	IPR002464
Domain	LAM_G_DOMAIN	CNTNAP4 FAT3	2.85e-03	38	39	2	PS50025
Domain	DEAH_ATP_HELICASE	CHD1 DHX30	2.85e-03	38	39	2	PS00690
Domain	Laminin_G_2	CNTNAP4 FAT3	3.15e-03	40	39	2	PF02210
Domain	LamG	CNTNAP4 FAT3	3.80e-03	44	39	2	SM00282
Domain	-	CFAP61 TXNRD2	6.09e-03	56	39	2	3.50.50.60
Domain	FAD/NAD-binding_dom	CFAP61 TXNRD2	6.31e-03	57	39	2	IPR023753
Domain	Laminin_G	CNTNAP4 FAT3	6.52e-03	58	39	2	IPR001791
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	1.29e-06	2	40	2	24813994
Pubmed	Human transcription factor protein interaction networks.	ZNF512B NCOA2 FLG SATB2 ZNF319 FLG2 AGO3 ATRX ATXN7 DHX30	3.65e-06	1429	40	10	35140242
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	3.87e-06	3	40	2	23403047
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	3.87e-06	3	40	2	28928464
Pubmed	The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.	CNTNAP4 TIAM1	3.87e-06	3	40	2	23395182
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	3.87e-06	3	40	2	32437351
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF512B CHD1 ATRX ATXN7 DHX30	5.56e-06	222	40	5	37071664
Pubmed	Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.	SATB2 CCSER2	7.73e-06	4	40	2	36795749
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF512B NCOA2 GPSM2 VPS54 TIAM1 ATRX DROSHA DHX30 CEP63	1.21e-05	1285	40	9	35914814
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	1.93e-05	6	40	2	27304082
Pubmed	Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.	CHD1 TIAM1	2.70e-05	7	40	2	22044751
Pubmed	ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain.	SATB2 ATRX	4.62e-05	9	40	2	25395668
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	DAB1 SEMA3D SATB2 ATRX DHX30	5.50e-05	358	40	5	32460013
Pubmed	Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs.	NCOA2 TXNRD2	7.05e-05	11	40	2	12612084
Pubmed	RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.	DAB1 SATB2	8.45e-05	12	40	2	29581187
Pubmed	Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.	DAB1 SATB2	1.16e-04	14	40	2	21460838
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	DAB1 NCOA2 SATB2	1.17e-04	82	40	3	31073041
Pubmed	Genetic variants associated with disordered eating.	DAB1 FLG FLG2	1.21e-04	83	40	3	23568457
Pubmed	Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus.	SATB2 CEP164	1.53e-04	16	40	2	34815315
Pubmed	Control of neuronal morphology by the atypical cadherin Fat3.	DAB1 FAT3	1.53e-04	16	40	2	21903076
Pubmed	Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.	AGO3 DROSHA	1.53e-04	16	40	2	20102707
Pubmed	Stalled replication forks within heterochromatin require ATRX for protection.	SATB2 ATRX	1.53e-04	16	40	2	27171262
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZNF512B CHD1 SCD5 TIAM1 ATRX NBR1 DHX30 CCSER2	2.48e-04	1487	40	8	33957083
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG FLG2	2.67e-04	21	40	2	19601998
Pubmed	Sidekick 2 directs formation of a retinal circuit that detects differential motion.	DAB1 SATB2	3.21e-04	23	40	2	26287463
Pubmed	Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.	GPSM2 TIAM1	3.50e-04	24	40	2	30814219
Pubmed	Centrosome anchoring regulates progenitor properties and cortical formation.	SATB2 CEP164	3.80e-04	25	40	2	32238932
Pubmed	Proteomic characterization of the human centrosome by protein correlation profiling.	CEP164 CEP63	4.12e-04	26	40	2	14654843
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DAB1 DHX30 CCSER2	4.35e-04	128	40	3	30995482
Pubmed	The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.	DAB1 SATB2	4.78e-04	28	40	2	18794345
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF512B FLG SATB2 FLG2 DHX30	6.23e-04	605	40	5	28977666
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF512B NCOA2 SATB2 FLG2	7.00e-04	351	40	4	38297188
Pubmed	NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.	FLG2 DROSHA DHX30	7.60e-04	155	40	3	33838681
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	ATRX SWT1	8.83e-04	38	40	2	28218735
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	SATB2 CEP63	8.83e-04	38	40	2	34059773
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	ANKRD30A TIAM1 CEP164	9.93e-04	170	40	3	23314748
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2	4.49e-05	7	27	2	1350
Coexpression	GSE22886_CD8_VS_CD4_NAIVE_TCELL_DN	DAB1 POMT2 NCOA2 TIAM1 ATXN7	1.18e-05	196	40	5	M4404
Coexpression	DESCARTES_FETAL_HEART_SATB2_LRRC7_POSITIVE_CELLS	DAB1 SATB2 SCD5 FAT3	2.84e-05	115	40	4	M40201
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	NCOA2 CACNB2 CHD1 ATRX USP51 SOWAHC SWT1 CEP164 FAT3 CCSER2 CEP63	2.52e-07	831	40	11	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000	NCOA2 CNTNAP4 HRC ZBP1 GPSM2 SATB2 TXNRD2 ATRX USP51 FAT3	9.93e-06	979	40	10	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	DAB1 NCOA2 ZBP1 GPSM2 CHD1 TXNRD2 ATRX SWT1 FAT3 DHX30	1.98e-05	1060	40	10	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500	DAB1 NCOA2 ZBP1 GPSM2 CHD1 CFAP61 TXNRD2 ATRX SWT1 FAT3 DHX30	4.20e-05	1414	40	11	facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	GPSM2 CACNB2 CHD1 SATB2 CFAP61 AGO3 ATRX SOWAHC SWT1 DHX30	8.16e-05	1252	40	10	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1	NCOA2 CACNB2 ZNF226 ATRX SOWAHC SWT1 CEP164 DHX30	8.66e-05	780	40	8	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 TIAM1 FAT3	5.69e-07	180	40	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 TIAM1 FAT3	5.69e-07	180	40	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	DAB1 SEMA3D CACNB2 SLC20A2 FAT3	7.06e-07	188	40	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.07e-05	181	40	4	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.45e-05	189	40	4	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.45e-05	189	40	4	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.50e-05	190	40	4	841cd55861b43578d704418b9bc0af2e8b88323a
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DAB1 SEMA3D CACNB2 FAT3	2.55e-05	191	40	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.60e-05	192	40	4	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.60e-05	192	40	4	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.60e-05	192	40	4	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.60e-05	192	40	4	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.66e-05	193	40	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 SEMA3D CACNB2 FAT3	2.71e-05	194	40	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SEMA3D CACNB2 TIAM1 FAT3	2.82e-05	196	40	4	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	DAB1 SATB2 SCD5 FAT3	2.94e-05	198	40	4	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	SEMA3D ATRX FAT3 CCSER2	3.00e-05	199	40	4	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	DAB1 SATB2 ATRX FAT3	3.00e-05	199	40	4	058373b4ac3cec2108cb24265628ff0a50646e33
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	NCOA2 CACNB2 SCD5 ATRX SLC20A2	2.15e-05	193	40	5	2852_UP
Drug	0198306-0000 [212631-61-3]; Down 200; 10uM; MCF7; HT_HG-U133A	POMT2 TIAM1 SOWAHC SLC39A9 CCSER2	2.26e-05	195	40	5	7099_DN
Drug	Oxamniquine [21738-42-1]; Down 200; 14.4uM; HL60; HT_HG-U133A	NCOA2 VPS54 AGO3 DHX30 CCSER2	2.31e-05	196	40	5	2924_DN
Drug	Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A	NCOA2 SCD5 TIAM1 SOWAHC SLC39A9	2.31e-05	196	40	5	2628_DN
Disease	brain disease (implicated_via_orthology)	TIAM1 DROSHA	2.54e-05	6	39	2	DOID:936 (implicated_via_orthology)
Disease	colorectal adenoma	DAB1 FAT3	8.76e-04	33	39	2	EFO_0005406
Disease	sphingolipid measurement	ANKRD30A CNTNAP4	1.29e-03	40	39	2	EFO_0004622
Disease	major depressive episode	CACNB2 SATB2	1.77e-03	47	39	2	EFO_0007634

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEDFAVHICHRHSHY	CFAP61	166	Q8NHU2
AEHYAVTCGFHHIHE	ANKRD30A	241	Q9BXX3
FTVDEHRHHFHARGE	CNTNAP4	286	Q9C0A0
RQGYHHEHSVDSSGH	FLG	3121	P20930
YHLVDKEHDSAEGSH	AGO3	816	Q9H9G7
GKHQYLHRHRHHESE	DHX30	631	Q7L2E3
SDRHLTQYHDHHKDR	CHD1	1546	O14646
TQYHDHHKDRHQGDS	CHD1	1551	O14646
KEDYSHDHVDHYASH	CACNB2	571	Q08289
HYASHRDHNHRDETH	CACNB2	581	Q08289
HRHSEHIHTQAGSHY	FLG2	1286	Q5D862
QTGDTTRHAHYHHGK	FLG2	1471	Q5D862
HDYAKALEYHHHDLT	GPSM2	76	P81274
EESVEKLDCHYSGHH	ATXN7	501	O15265
DHYHHHGKSDLSRGS	CCSER2	611	Q9H7U1
EHIVGYHEHDSLLDH	ATRX	2246	P46100
HHHAVHEISYIAKDI	DAB1	106	O75553
HGQHRHDGIKTEHYK	CEP63	561	Q96MT8
HETIAHFHFHVHVRD	FAT3	1841	Q8TDW7
GHEDTGHSLHDYKEA	ADA2	326	Q9NZK5
ENGRHTHTYTHRHTH	FAM27E3	96	Q08E93
HTRSDGHVYHTVHKD	SLC20A2	336	Q08357
EHSHDHTQLHAYIGV	SLC39A9	96	Q9NUM3
KHYDDHRHRDHSHGR	DROSHA	226	Q9NRR4
HKETSRNLHSHYHEA	POMT2	416	Q9UKY4
RQKSYDHSRHHHGSS	NBR1	866	Q14596
YEEESRHHHSERMQH	SATB2	556	Q9UPW6
HRAHHKYSETDADPH	SCD5	131	Q86SK9
YKLSHALEDGGDHHH	SOWAHC	426	Q53LP3
DEVVSSEHHHHILRH	HRC	166	P23327
FQDEYKTEVPHHHHH	HRC	406	P23327
KRKHHYDHQESNDSH	SWT1	301	Q5T5J6
PTHDHHYIRTDISEH	SEMA3D	221	O95025
HRVHQKSYHVAGYEH	CEP164	816	Q9UPV0
HEGESVSYAKRHHHE	NCOA2	311	Q15596
HAETKQHHLAVDLYH	USP51	266	Q70EK9
HKAAEGSHYVDEASH	ZBP1	406	Q9H171
SQHVEHEFYGEKHAS	TIAM1	6	Q13009
HHDGHRVHKSEKSYR	ZNF226	211	Q9NYT6
SKAGHDYHVRSEHTA	ZNF512B	641	Q96KM6
SHLVRHMYAHSGEHH	ZNF319	271	Q9P2F9
VARHGQEHVEVYHAH	TXNRD2	416	Q9NNW7
RHFDHITKDYHDHIA	VPS54	841	Q9P1Q0
SYHHCFRKHERTHTG	ZNF14	151	P17017