Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 PSEN2 ERVK-7 ERVK-8 ERVK-19 ERVK-25

5.66e-07371666GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 PSEN2 ERVK-7 ERVK-8 ERVK-19 ERVK-25

6.68e-07381666GO:0070001
GeneOntologyMolecularFunctionactin filament binding

TMEM201 MYO7B DBNL MICALL2 AVIL TLN1 TLN2 TAGLN2 MYO18B VCL

2.10e-0522716610GO:0051015
GeneOntologyMolecularFunctioncytoskeletal protein binding

TMEM201 ANK3 MYO7B DBNL ARFGEF2 APOE DYSF CCDC88B KIF24 MAPK8IP3 TAOK2 MICALL2 STARD9 NISCH AVIL TLN1 TLN2 KIF2A TAGLN2 MYO18B CORO7 UNC13A VCL

4.13e-05109916623GO:0008092
GeneOntologyMolecularFunctioncell adhesion molecule binding

COMP ANK3 LAD1 DBNL NECTIN3 LILRB1 NLGN3 NISCH TLN1 TLN2 TNKS1BP1 TAGLN2 CTNND2 CX3CL1 VSIG10L2 VCL

4.15e-0559916616GO:0050839
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-8

8.86e-05111663GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-8

1.92e-04141663GO:0003964
GeneOntologyMolecularFunctionIkappaB kinase activity

CHUK IKBKE

2.05e-0431662GO:0008384
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8

6.72e-04211663GO:0035613
GeneOntologyBiologicalProcesspositive regulation of type I interferon production

MYD88 TICAM1 OAS1 IRF1 CHUK IKBKE TLR3

3.46e-06811627GO:0032481
GeneOntologyBiologicalProcessregulation of type I interferon production

MYD88 TICAM1 OAS1 IRF1 LILRB1 CHUK IKBKE TLR3

1.59e-051411628GO:0032479
GeneOntologyBiologicalProcesstype I interferon production

MYD88 TICAM1 OAS1 IRF1 LILRB1 CHUK IKBKE TLR3

1.95e-051451628GO:0032606
GeneOntologyBiologicalProcessregulation of glutamate receptor signaling pathway

NLGN3 CX3CL1 UNC13A

2.59e-0581623GO:1900449
GeneOntologyBiologicalProcessmacrophage cytokine production

MYD88 PSEN2 TICAM1 LILRB1 TLR3

7.12e-05551625GO:0010934
GeneOntologyBiologicalProcessendolysosomal toll-like receptor signaling pathway

MYD88 TICAM1 OAS1 IRF1 TLR3

7.77e-05561625GO:0140894
GeneOntologyBiologicalProcessviral process

ERVK-6 VPS4A WWP1 OAS1 RCC1 ERVK-7 NECTIN3 APOE TYRO3 GRK2 CLEC4G ERVK-8 ERVK-19

7.93e-0546416213GO:0016032
GeneOntologyBiologicalProcessdefense response to virus

MYD88 TICAM1 OAS1 IRF1 AZI2 LILRB1 CHUK IKBKE PRF1 TLR3 MICA

8.55e-0534216211GO:0051607
GeneOntologyBiologicalProcesstoll-like receptor 3 signaling pathway

TICAM1 OAS1 IRF1 TLR3

9.78e-05311624GO:0034138
GeneOntologyBiologicalProcesstumor necrosis factor production

MYD88 PSEN2 TICAM1 ARFGEF2 OAS1 AZI2 LILRB1 TLR3 CX3CL1

1.10e-042371629GO:0032640
GeneOntologyBiologicalProcesscell-cell adhesion

COMP ANK3 NT5E IRF1 PODXL2 NECTIN3 CCDC88B LILRB1 TAOK2 TYRO3 NLGN3 FAT2 TLN1 CLEC4G ASTN1 TLN2 CTNND2 CX3CL1 MUC4 VSIG10L2 VCL

1.11e-04107716221GO:0098609
GeneOntologyBiologicalProcesspositive regulation of macrophage cytokine production

MYD88 TICAM1 LILRB1 TLR3

1.26e-04331624GO:0060907
GeneOntologyBiologicalProcessnuclear-transcribed mRNA poly(A) tail shortening

TNRC6B TNRC6C TNRC6A TNKS1BP1

1.26e-04331624GO:0000289
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-8

1.28e-04131623GO:0015074
GeneOntologyBiologicalProcesstumor necrosis factor superfamily cytokine production

MYD88 PSEN2 TICAM1 ARFGEF2 OAS1 AZI2 LILRB1 TLR3 CX3CL1

1.33e-042431629GO:0071706
GeneOntologyBiologicalProcesspositive regulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6B TNRC6C TNRC6A

1.62e-04141623GO:0060213
GeneOntologyBiologicalProcesschemical synaptic transmission, postsynaptic

TRPV1 CHRNB2 TMEM25 NLGN3 GRK2 NPFF CX3CL1

1.64e-041471627GO:0099565
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

MYD88 TICAM1 OAS1 IRF1 APOE LILRB1 CHUK TYRO3 IKBKE NFKBIA TLR3 MICA INAVA CX3CL1 MUC4

1.72e-0464316215GO:0002831
GeneOntologyBiologicalProcessdendrite morphogenesis

HECW1 DBNL CHRNB2 TAOK2 NLGN3 ANAPC2 CTNND2 EPHA4

1.75e-041981628GO:0048813
GeneOntologyBiologicalProcessT cell mediated cytotoxicity

LILRB1 CD1B PRF1 MICA MUC4

2.25e-04701625GO:0001913
GeneOntologyBiologicalProcesscell junction organization

PSEN2 ANK3 DBNL NECTIN3 APOE CHRNB2 TAOK2 KY NLGN3 MICALL2 TLN1 ANAPC2 TLN2 INAVA CTNND2 CX3CL1 UNC13A VCL EPHA4

2.39e-0497416219GO:0034330
GeneOntologyBiologicalProcessregulation of innate immune response

MYD88 TICAM1 OAS1 IRF1 APOE LILRB1 CHUK TYRO3 IKBKE NFKBIA TLR3 MICA INAVA

2.39e-0451916213GO:0045088
GeneOntologyBiologicalProcesstoll-like receptor 4 signaling pathway

MYD88 TICAM1 OAS1 CHUK NFKBIA

2.41e-04711625GO:0034142
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6B TNRC6C TNRC6A

2.47e-04161623GO:0060211
GeneOntologyBiologicalProcessmyeloid leukocyte cytokine production

MYD88 PSEN2 TICAM1 LILRB1 TLR3

2.57e-04721625GO:0061082
GeneOntologyBiologicalProcessinterferon-beta production

TICAM1 OAS1 IRF1 LILRB1 TLR3

2.74e-04731625GO:0032608
GeneOntologyBiologicalProcessregulation of interferon-beta production

TICAM1 OAS1 IRF1 LILRB1 TLR3

2.74e-04731625GO:0032648
GeneOntologyBiologicalProcesscanonical NF-kappaB signal transduction

MYD88 TICAM1 IRF1 AZI2 CHUK IKBKE NFKBIA TLR3 INAVA CX3CL1

2.90e-0433016210GO:0007249
GeneOntologyBiologicalProcesssynapse organization

PSEN2 ANK3 DBNL NECTIN3 APOE CHRNB2 TAOK2 KY NLGN3 ANAPC2 TLN2 CTNND2 CX3CL1 UNC13A EPHA4

3.38e-0468516215GO:0050808
GeneOntologyBiologicalProcessinterleukin-6 production

MYD88 PSEN2 TICAM1 AZI2 GRK2 TLR3 INAVA CX3CL1

3.68e-042211628GO:0032635
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

TRPV1 PSEN2 APOE DYSF LILRB1 SHC3 CHRNB2 TMEM25 NLGN3 GRK2 NPFF NISCH ANAPC2 CTNND2 CADPS2 CX3CL1 UNC13A EPHA4

3.90e-0493116218GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

TRPV1 PSEN2 APOE DYSF LILRB1 SHC3 CHRNB2 TMEM25 NLGN3 GRK2 NPFF NISCH ANAPC2 CTNND2 CADPS2 CX3CL1 UNC13A EPHA4

3.90e-0493116218GO:0007268
GeneOntologyBiologicalProcesscell surface toll-like receptor signaling pathway

MYD88 TICAM1 OAS1 CHUK NFKBIA

3.96e-04791625GO:0140895
GeneOntologyBiologicalProcesstrans-synaptic signaling

TRPV1 PSEN2 APOE DYSF LILRB1 SHC3 CHRNB2 TMEM25 NLGN3 GRK2 NPFF NISCH ANAPC2 CTNND2 CADPS2 CX3CL1 UNC13A EPHA4

4.32e-0493916218GO:0099537
GeneOntologyBiologicalProcesspositive regulation of myeloid leukocyte cytokine production involved in immune response

MYD88 TICAM1 LILRB1 TLR3

4.63e-04461624GO:0061081
GeneOntologyBiologicalProcesspositive regulation of interferon-beta production

TICAM1 OAS1 IRF1 TLR3

5.03e-04471624GO:0032728
GeneOntologyBiologicalProcessregulation of synaptic plasticity

PSEN2 APOE LILRB1 NLGN3 ANAPC2 CTNND2 CX3CL1 UNC13A EPHA4

5.29e-042931629GO:0048167
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

MYD88 TICAM1 OAS1 IRF1 CHUK TYRO3 NFKBIA TLR3 INAVA

5.43e-042941629GO:0002221
GeneOntologyBiologicalProcessregulation of macrophage cytokine production

MYD88 TICAM1 LILRB1 TLR3

5.45e-04481624GO:0010935
GeneOntologyBiologicalProcessresponse to interferon-beta

OAS1 IRF1 IKBKE TLR3

5.45e-04481624GO:0035456
GeneOntologyBiologicalProcessresponse to virus

MYD88 TICAM1 OAS1 IRF1 AZI2 LILRB1 CHUK IKBKE PRF1 TLR3 MICA

5.52e-0442516211GO:0009615
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

TRPV1 CHRNB2 TMEM25 NLGN3 GRK2 NPFF CX3CL1

5.62e-041801627GO:0060078
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

TRPV1 CHRNB2 TMEM25 NLGN3 GRK2 NPFF

5.72e-041301626GO:0060079
GeneOntologyBiologicalProcessregulation of canonical NF-kappaB signal transduction

MYD88 TICAM1 AZI2 CHUK IKBKE NFKBIA TLR3 INAVA CX3CL1

5.98e-042981629GO:0043122
GeneOntologyBiologicalProcesspositive regulation of glutamate receptor signaling pathway

NLGN3 UNC13A

6.04e-0451622GO:1900451
GeneOntologyBiologicalProcesscell surface pattern recognition receptor signaling pathway

MYD88 TICAM1 OAS1 CHUK NFKBIA

6.18e-04871625GO:0002752
GeneOntologyBiologicalProcesstoll-like receptor signaling pathway

MYD88 TICAM1 IRF1 TYRO3 TLR3

6.51e-04881625GO:0002224
GeneOntologyBiologicalProcessI-kappaB phosphorylation

CHUK TLR3 CX3CL1

6.56e-04221623GO:0007252
GeneOntologyBiologicalProcessregulation of postsynapse organization

PSEN2 DBNL NECTIN3 APOE TAOK2 NLGN3 EPHA4

6.61e-041851627GO:0099175
GeneOntologyBiologicalProcesssynaptic signaling

TRPV1 PSEN2 APOE DYSF LILRB1 SHC3 CHRNB2 TMEM25 NLGN3 GRK2 NPFF NISCH ANAPC2 CTNND2 CADPS2 CX3CL1 UNC13A EPHA4

6.78e-0497616218GO:0099536
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

MYD88 TICAM1 OAS1 IRF1 NFKBIA TLR3 INAVA

7.26e-041881627GO:0002753
GeneOntologyBiologicalProcesspositive regulation of cytokine production

MYD88 TICAM1 ARFGEF2 OAS1 IRF1 CCDC88B LILRB1 CHUK GRK2 IKBKE TLR3 INAVA CX3CL1

7.51e-0458616213GO:0001819
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

PSEN2 APOE DYSF LILRB1 CHRNB2 TMEM25 NLGN3 GRK2 NISCH ANAPC2 CTNND2 CX3CL1 UNC13A EPHA4

7.63e-0466316214GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

PSEN2 APOE DYSF LILRB1 CHRNB2 TMEM25 NLGN3 GRK2 NISCH ANAPC2 CTNND2 CX3CL1 UNC13A EPHA4

7.74e-0466416214GO:0099177
GeneOntologyBiologicalProcessregulation of T cell mediated cytotoxicity

LILRB1 CD1B MICA MUC4

7.96e-04531624GO:0001914
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

MYD88 TICAM1 OAS1 IRF1 CHUK TYRO3 NFKBIA TLR3 INAVA

8.28e-043121629GO:0002758
MousePhenoabnormal response to injury

MYD88 NPR1 TRPV1 COMP NT5E TICAM1 IRF1 SIRT7 APOE DYSF CHRNB2 AEBP1 TLR3 BUB1B CORO7 CX3CL1 BBC3 SERPIND1

7.31e-0660712518MP:0005164
MousePhenoabnormal maternal nurturing

APOE FIGN AEBP1 CADPS2 MOCOS EPHA4 HR

4.25e-051051257MP:0001386
MousePhenoincreased susceptibility to Picornaviridae infection

MYD88 TICAM1 PRF1 TLR3

4.73e-05231254MP:0020937
MousePhenoincreased susceptibility to Coronaviridae infection

MYD88 TICAM1 TLR3 MUC4

5.64e-05241254MP:0020949
MousePhenoincreased susceptibility to Riboviria infection

MYD88 TICAM1 OAS1 IKBKE PRF1 TLR3 MUC4

6.81e-051131257MP:0020913
MousePhenoabnormal maternal behavior

APOE FIGN AEBP1 CADPS2 MOCOS EPHA4 HR

7.61e-051151257MP:0008779
MousePhenodecreased tumor necrosis factor secretion

MYD88 TICAM1 AZI2 APOE CCDC88B TLR3 CNPY3

1.29e-041251257MP:0008561
MousePhenoincreased susceptibility to Riboviria infection induced morbidity/mortality

MYD88 TICAM1 PRF1 TLR3 MUC4

1.40e-04561255MP:0031024
MousePhenoincreased susceptibility to viral infection

MYD88 TICAM1 OAS1 IRF1 IKBKE PRF1 TLR3 MUC4

1.55e-041721258MP:0002418
MousePhenoabnormal retina progenitor cell morphology

MYD88 TICAM1 FIGN

1.87e-04131253MP:0006071
MousePhenoabnormal response to infection

MYD88 TICAM1 OAS1 IRF1 APOE TGM6 KDM6B CCDC88B SIGLEC7 IKBKE PRF1 NFKBIA TLR3 CLEC4G INAVA ZKSCAN4 MUC4

2.05e-0471412517MP:0005025
MousePhenoincreased susceptibility to Herpesvirales infection

MYD88 TICAM1 IRF1 PRF1 TLR3

2.10e-04611255MP:0020916
MousePhenoabnormal tumor necrosis factor secretion

MYD88 TRPV1 TICAM1 AZI2 APOE CCDC88B PRF1 TLR3 CNPY3

2.21e-042301259MP:0008556
MousePhenoabnormal NK T cell physiology

MYD88 TICAM1 TLR3

2.36e-04141253MP:0008042
MousePhenoincreased left ventricle developed pressure

TRPV1 BBC3

2.37e-0431252MP:0003823
MousePhenoabnormal response to antigen

MYD88 TICAM1 OAS1 IRF1 APOE TGM6 KDM6B CCDC88B SIGLEC7 IKBKE PRF1 NFKBIA TLR3 CLEC4G INAVA ZKSCAN4 MUC4

2.49e-0472612517MP:0020000
DomainAgo_hook

TNRC6B TNRC6C TNRC6A

6.17e-0731603PF10427
DomainTNRC6_PABC-bd

TNRC6B TNRC6C TNRC6A

6.17e-0731603IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6C TNRC6A

6.17e-0731603IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6C TNRC6A

6.17e-0731603PF16608
DomainVinculin/catenin

TLN1 TLN2 VCL

2.11e-0571603IPR006077
Domain-

TLN1 TLN2

7.29e-05216021.20.1420.10
DomainVBS

TLN1 TLN2

7.29e-0521602PF08913
DomainVinculin-bd_dom

TLN1 TLN2

7.29e-0521602IPR015009
DomainTalin_cent

TLN1 TLN2

7.29e-0521602IPR015224
DomainM_domain

TNRC6C TNRC6A

7.29e-0521602PF12938
DomainGW182_M_dom

TNRC6C TNRC6A

7.29e-0521602IPR026805
DomainTalin_middle

TLN1 TLN2

7.29e-0521602PF09141
DomainC2

HECW1 WWP1 DYSF SYT16 PRF1 CADPS2 UNC13A

1.36e-041311607PF00168
DomainC2

HECW1 WWP1 DYSF SYT16 PRF1 CADPS2 UNC13A

1.80e-041371607SM00239
DomainTalin-1

TLN1 TLN2

2.18e-0431602IPR015710
DomainC2

HECW1 WWP1 DYSF SYT16 PRF1 CADPS2 UNC13A

2.24e-041421607PS50004
DomainILWEQ_dom

TLN1 TLN2

4.33e-0441602IPR002558
DomainILWEQ

TLN1 TLN2

4.33e-0441602SM00307
DomainFERM_f0

TLN1 TLN2

4.33e-0441602PF16511
DomainILWEQ

TLN1 TLN2

4.33e-0441602PD011820
Domain-

TLN1 TLN2

4.33e-04416021.20.1410.10
DomainI_LWEQ

TLN1 TLN2

4.33e-0441602PF01608
DomainI_LWEQ

TLN1 TLN2

4.33e-0441602PS50945
DomainFERM_f0

TLN1 TLN2

4.33e-0441602IPR032425
DomainC2_dom

HECW1 WWP1 DYSF SYT16 PRF1 CADPS2 UNC13A

5.37e-041641607IPR000008
DomainDUF1041

CADPS2 UNC13A

7.17e-0451602SM01145
DomainZF_HIT

ZNHIT6 ZNHIT2

1.07e-0361602PS51083
Domainzf-HIT

ZNHIT6 ZNHIT2

1.07e-0361602PF04438
DomainZnf_HIT

ZNHIT6 ZNHIT2

1.07e-0361602IPR007529
DomainTIR

MYD88 TICAM1 TLR3

1.09e-03241603PS50104
DomainTIR_dom

MYD88 TICAM1 TLR3

1.24e-03251603IPR000157
DomainMunc13_1

CADPS2 UNC13A

1.49e-0371602IPR014770
DomainMHD1

CADPS2 UNC13A

1.49e-0371602PS51258
DomainDUF1041

CADPS2 UNC13A

1.49e-0371602PF06292
DomainCAPS_dom

CADPS2 UNC13A

1.49e-0371602IPR010439
PathwayREACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1

MYD88 TICAM1 CHUK NFKBIA TLR3

1.38e-07171085M583
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION

MYD88 TICAM1 OAS1 CHUK IKBKE NFKBIA

1.65e-07331086M39909
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

MYD88 TICAM1 CHUK NFKBIA TLR3

4.44e-07211085M26978
PathwayKEGG_MEDICUS_REFERENCE_TLR3_NFKB_SIGNALING_PATHWAY

TICAM1 CHUK NFKBIA TLR3

6.60e-07101084M47601
PathwayWP_TLR4_SIGNALING_AND_TOLERANCE

MYD88 TICAM1 CHUK IKBKE NFKBIA

2.05e-06281085M39561
PathwayWP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88

MYD88 TICAM1 CHUK IKBKE TLR3

3.49e-06311085M39573
PathwayREACTOME_DISEASES_OF_IMMUNE_SYSTEM

MYD88 TICAM1 CHUK NFKBIA TLR3

4.11e-06321085M27428
PathwayWP_TOLLLIKE_RECEPTOR_SIGNALING

MYD88 TICAM1 CHUK IKBKE TLR3

4.81e-06331085MM15940
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6C TNRC6A

1.50e-0571083M46421
PathwayPID_TOLL_ENDOGENOUS_PATHWAY

MYD88 TICAM1 CHUK TLR3

3.08e-05241084M264
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

TNRC6B TNRC6C TNRC6A

3.55e-0591083M27810
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

TICAM1 IKBKE TLR3

3.55e-0591083M47451
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAB_C_D_TO_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

TLN1 TLN2 VCL

3.55e-0591083M47725
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

TNRC6B TNRC6C TNRC6A

3.55e-0591083M46436
PathwayBIOCARTA_TOLL_PATHWAY

MYD88 CHUK NFKBIA TLR3

3.64e-05251084M984
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

TNRC6B TNRC6C TNRC6A

5.05e-05101083M48013
PathwayREACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION

TICAM1 IKBKE TLR3

6.90e-05111083M48241
PathwayWP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION

MYD88 OAS1 IKBKE TLR3

8.74e-05311084M39859
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

MYD88 CHUK NFKBIA

1.18e-04131083MM14616
PathwayREACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7

TICAM1 IKBKE TLR3

1.18e-04131083M27884
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

TNRC6B TNRC6C TNRC6A

1.18e-04131083M46434
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

MYD88 TICAM1 CHUK NFKBIA TLR3

1.28e-04641085M27046
PathwayKEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY

MYD88 TICAM1 CHUK IKBKE NFKBIA TLR3

1.30e-041021086M3261
PathwayWP_TOLLLIKE_RECEPTOR_SIGNALING

MYD88 TICAM1 CHUK IKBKE NFKBIA TLR3

1.38e-041031086M39434
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

TNRC6B TNRC6C APOE TNRC6A

1.77e-04371084M29790
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

TNRC6B TNRC6C ANAPC2 TNRC6A

2.65e-04411084M29748
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

TNRC6B TNRC6C TNRC6A

2.75e-04171083M27788
PathwayKEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY

MYD88 CHUK NFKBIA

2.75e-04171083M47912
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING

MYD88 TICAM1 CHUK TLR3

3.19e-04431084M39744
PathwayREACTOME_TOLL_LIKE_RECEPTOR_CASCADES

MYD88 TICAM1 CHUK IKBKE NFKBIA TLR3 CNPY3

3.29e-041701087M7494
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

TNRC6B TNRC6C TNRC6A

3.88e-04191083M48238
PathwayREACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT

TICAM1 CHUK TLR3

3.88e-04191083M27020
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY

TICAM1 IKBKE TLR3

3.88e-04191083M47450
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

TNRC6B TNRC6C APOE TNRC6A

4.51e-04471084M29777
PathwayKEGG_MEDICUS_REFERENCE_TLR1_2_4_NFKB_SIGNALING_PATHWAY

MYD88 CHUK NFKBIA

4.53e-04201083M47563
PathwayBIOCARTA_RHO_PATHWAY

PPP1R12B TLN1 VCL

4.53e-04201083MM1476
PathwayREACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2

A1BG F8 HABP4 TLN1 TAGLN2 VCL

4.86e-041301086MM15455
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING_PATHWAY

MYD88 TICAM1 CHUK TLR3

4.89e-04481084MM15897
PathwayBIOCARTA_NFKB_PATHWAY

MYD88 CHUK NFKBIA

5.26e-04211083MM1444
PathwayBIOCARTA_RHO_PATHWAY

PPP1R12B TLN1 VCL

5.26e-04211083M1001
PathwayBIOCARTA_NFKB_PATHWAY

MYD88 CHUK NFKBIA

5.26e-04211083M15285
PathwayWP_STING_PATHWAY_IN_KAWASAKILIKE_DISEASE_AND_COVID19

CHUK IKBKE NFKBIA

5.26e-04211083M40061
PathwayREACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2

A1BG F8 HABP4 TLN1 TAGLN2 VCL

5.27e-041321086M724
PathwayREACTOME_SIGNALING_BY_TGFBR3

PSEN2 TNRC6B TNRC6C TNRC6A

5.29e-04491084M48250
PathwayWP_APOPTOSIS

IRF1 CHUK PRF1 NFKBIA BBC3

5.69e-04881085M39654
PathwayBIOCARTA_NTHI_PATHWAY

MYD88 CHUK NFKBIA

6.06e-04221083MM1443
PathwayWP_MEASLES_VIRUS_INFECTION

MYD88 OAS1 CHUK IKBKE NFKBIA BBC3

6.17e-041361086M42547
PathwayBIOCARTA_NTHI_PATHWAY

MYD88 CHUK NFKBIA

6.93e-04231083M2821
PathwayBIOCARTA_TOLL_PATHWAY

MYD88 CHUK NFKBIA

7.87e-04241083MM1518
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6A

8.55e-0461082MM15083
PathwayREACTOME_TLR3_MEDIATED_TICAM1_DEPENDENT_PROGRAMMED_CELL_DEATH

TICAM1 TLR3

8.55e-0461082M27883
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

8.55e-0461082M47462
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

TNRC6B NECTIN3 TNRC6C TNRC6A

1.01e-03581084M11980
PathwayWP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY

AZI2 CHUK IKBKE NFKBIA

1.14e-03601084M39583
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

MYD88 PSEN2 CHUK ARHGEF40 IKBKE NFKBIA

1.18e-031541086M27697
PathwayREACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID

CHUK NFKBIA

1.19e-0371082M27463
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_TNF_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

1.19e-0371082M47464
PathwayREACTOME_TGFBR3_EXPRESSION

TNRC6B TNRC6C TNRC6A

1.25e-03281083M48253
PathwayREACTOME_CA2_PATHWAY

TCF7 TNRC6B TNRC6C TNRC6A

1.29e-03621084M27321
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

TLN1 TLN2 VCL

1.53e-03301083M47724
PathwayWP_MIRNA_ROLE_IN_IMMUNE_RESPONSE_IN_SEPSIS

MYD88 IRF1 CHUK NFKBIA

1.54e-03651084M39354
PathwayWP_CANONICAL_NFKB_PATHWAY

CHUK NFKBIA

1.58e-0381082M39783
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_K15_TO_TNF_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

1.58e-0381082M47463
PathwayBIOCARTA_IL1R_PATHWAY

MYD88 CHUK NFKBIA

1.68e-03311083M12095
PathwayWP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY

TICAM1 IKBKE TLR3

1.68e-03311083M39897
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

TNRC6B TNRC6C TNRC6A

1.85e-03321083M48012
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

MYD88 CHUK NFKBIA

1.85e-03321083MM14707
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

TNRC6B TNRC6C TNRC6A

1.85e-03321083M27900
PathwayWP_SIGNAL_TRANSDUCTION_THROUGH_IL1R

MYD88 CHUK NFKBIA

2.02e-03331083M39803
PathwayREACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA

CHUK IKBKE NFKBIA

2.02e-03331083MM14666
PathwayBIOCARTA_INTEGRIN_PATHWAY

PPP1R12B TLN1 VCL

2.02e-03331083MM1426
PathwayWP_MITOCHONDRIAL_IMMUNE_RESPONSE_TO_SARSCOV2

TICAM1 IKBKE TLR3

2.02e-03331083M40066
PathwayWP_ALTERED_GLYCOSYLATION_OF_MUC1_IN_TUMOR_MICROENVIRONMENT

CHUK NFKBIA

2.02e-0391082M39757
PathwayKEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY

TICAM1 IKBKE

2.02e-0391082M47598
PathwayWP_SUPPRESSION_OF_HMGB1MEDIATED_INFLAMMATION_BY_THBD

CHUK NFKBIA

2.02e-0391082M39509
PathwayKEGG_MEDICUS_REFERENCE_NOD_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

2.02e-0391082M47652
PathwayBIOCARTA_RNA_PATHWAY

CHUK NFKBIA

2.02e-0391082MM1382
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_E2_TO_NOD_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

2.02e-0391082M47734
PathwayKEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY

AZI2 CHUK IKBKE NFKBIA

2.13e-03711084M15913
PathwayBIOCARTA_INTEGRIN_PATHWAY

PPP1R12B TLN1 VCL

2.20e-03341083M3342
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

TNRC6B TNRC6C TNRC6A

2.20e-03341083M46422
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

TNRC6B TNRC6C TNRC6A

2.39e-03351083M27190
PathwayKEGG_MEDICUS_REFERENCE_LIGHT_HVEM_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

2.51e-03101082M47599
PathwayBIOCARTA_RNA_PATHWAY

CHUK NFKBIA

2.51e-03101082M10570
PathwayREACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX

TICAM1 TLR3

3.06e-03111082M27885
PathwayKEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_NFKB_SIGNALING_PATHWAY

CHUK NFKBIA

3.06e-03111082M47493
Pubmed

Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.

MYD88 TICAM1 IRF1 CHUK

6.65e-089169419201871
Pubmed

Vinculin and talin: focus on the myocardium.

TLN1 TLN2 VCL

1.13e-073169319952892
Pubmed

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

TLN1 TLN2 VCL

1.13e-073169315494027
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6B TNRC6C TNRC6A

1.13e-073169316880270
Pubmed

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

TNRC6B TNRC6C TNRC6A

1.13e-073169331670606
Pubmed

Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.

TLN1 TLN2 VCL

1.13e-073169327816808
Pubmed

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

TNRC6B TNRC6C TNRC6A

1.13e-073169334108231
Pubmed

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.

MYD88 TICAM1 IKBKE

1.13e-073169330853218
Pubmed

Vinculin controls talin engagement with the actomyosin machinery.

TLN1 TLN2 VCL

1.13e-073169326634421
Pubmed

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

MYD88 TICAM1 PRF1 TLR3

3.72e-0713169420585036
Pubmed

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

MYD88 TICAM1 TLR3

4.49e-074169314625548
Pubmed

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

TNRC6B TNRC6C TNRC6A

4.49e-074169321063388
Pubmed

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.

MYD88 TICAM1 TLR3

4.49e-074169329041928
Pubmed

Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms.

MYD88 TICAM1 TLR3

4.49e-074169325152077
Pubmed

TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

MYD88 TICAM1 TLR3

4.49e-074169320957750
Pubmed

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.

MYD88 TICAM1 TLR3

4.49e-074169319158348
Pubmed

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms.

MYD88 TICAM1 TLR3

4.49e-074169328768728
Pubmed

Activation of IKK/NF-κB provokes renal inflammatory responses in guanylyl cyclase/natriuretic peptide receptor-A gene-knockout mice.

NPR1 CHUK NFKBIA

4.49e-074169322318993
Pubmed

Polyinosinic acid is a ligand for toll-like receptor 3.

MYD88 TICAM1 TLR3

4.49e-074169317573354
Pubmed

Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.

MYD88 TICAM1 TLR3

4.49e-074169326363072
Pubmed

Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.

TICAM1 AZI2 TLR3

4.49e-074169317982077
Pubmed

Vinculin regulates assembly of talin: β3 integrin complexes.

TLN1 TLN2 VCL

4.49e-074169324446374
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX3 WWP1 RTTN LAD1 ARFGEF2 TNRC6C KDM6B DYSF MAPK8IP3 TAOK2 CCDC142 ARHGEF40 NISCH TLN1 HELZ2 NINL TLN2 TNKS1BP1 CEP131 HR

4.86e-0711051692035748872
Pubmed

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

MYD88 TICAM1 IRF1 TLR3

5.19e-0714169430510167
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RBBP8 TTC27 TNRC6B RCC1 BCOR RBM20 BUB1B TNRC6A TNKS1BP1 CEP131 ZKSCAN4 WDR62

1.08e-064181691234709266
Pubmed

MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase.

MYD88 TICAM1 TLR3

1.12e-065169318057004
Pubmed

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.

MYD88 CHUK NFKBIA

1.12e-065169316365431
Pubmed

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

MYD88 TICAM1 TLR3

1.12e-065169325756897
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

1.12e-065169312629516
Pubmed

Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.

MYD88 TRPV1 TLR3

1.12e-065169324698267
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF133 SESTD1 ANK3 USP11 ARFGEF2 TTC27 ZNF202 APOE KDM6B MAPK8IP3 CHUK CYRIA KANSL2 NISCH NABP2 ASTN1 TLN2 USP54 CTNND2 CADPS2 TARBP1

1.27e-0612851692135914814
Pubmed

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.

MYD88 TICAM1 TLR3

2.23e-066169317190817
Pubmed

The TLR4-TRIF pathway protects against H5N1 influenza virus infection.

MYD88 TICAM1 TLR3

2.23e-066169322031950
Pubmed

Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity.

MYD88 TICAM1 TLR3

2.23e-066169322124111
Pubmed

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

TLN1 TLN2 VCL

2.23e-066169322925892
Pubmed

All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.

CHUK IKBKE NFKBIA

2.23e-06616939914500
Pubmed

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

MYD88 TICAM1 IRF1

2.23e-066169330046112
Pubmed

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

MYD88 TICAM1 TLR3

2.23e-066169324572365
Pubmed

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

MYD88 TICAM1 TLR3

2.23e-066169316625202
Pubmed

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.

MYD88 TICAM1 TLR3

2.23e-066169316301743
Pubmed

NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.

AZI2 IKBKE TLR3

2.23e-066169317142768
Pubmed

UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

MYD88 TICAM1 TLR3

2.23e-066169320865117
Pubmed

The role of hyaluronan degradation products as innate alloimmune agonists.

MYD88 TICAM1 TLR3

2.23e-066169317049055
Pubmed

NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.

CHUK IKBKE NFKBIA

2.23e-066169311959143
Pubmed

A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.

MYD88 TICAM1 TLR3

2.23e-066169328564605
Pubmed

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

MYD88 IRF1 TLR3

2.23e-066169328970238
Pubmed

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

MYD88 TICAM1 IRF1 TLR3

2.45e-0620169432150572
Pubmed

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.

MYD88 TICAM1 TLR3

3.89e-067169319995952
Pubmed

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

TICAM1 IKBKE TLR3

3.89e-067169312692549
Pubmed

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

MYD88 TICAM1 TLR3

3.89e-067169325964372
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

TNRC6B TNRC6C TNRC6A

3.89e-067169319383768
Pubmed

Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

TLN1 TLN2 VCL

3.89e-067169323266827
Pubmed

Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response.

MYD88 TICAM1 TLR3

3.89e-067169325937283
Pubmed

RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.

MYD88 TICAM1 TLR3

3.89e-067169323408632
Pubmed

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.

MYD88 TICAM1 TLR3

3.89e-067169322072781
Pubmed

Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.

MYD88 TICAM1 PRF1

3.89e-067169319009526
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

TNRC6B TNRC6C TNRC6A

3.89e-067169319470757
Pubmed

Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.

MYD88 TICAM1 TLR3

3.89e-067169316142239
Pubmed

Kinesin family member 2A gates nociception.

TRPV1 AVIL KIF2A

3.89e-067169337851573
Pubmed

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.

MYD88 TICAM1 PRF1

3.89e-067169319406986
Pubmed

NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA.

MYD88 TICAM1 TLR3

3.89e-067169322184724
Pubmed

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.

MYD88 TICAM1 TLR3

3.89e-067169322123964
Pubmed

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

MYD88 TICAM1 IKBKE

3.89e-067169316286919
Pubmed

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.

MYD88 TICAM1 TLR3

3.89e-067169316272328
Pubmed

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.

MYD88 TICAM1 TLR3

3.89e-067169327716849
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

TNRC6B AZI2 TNRC6C CHUK GRK2 BUB1B TNRC6A TAGLN2 USP54 CORO7

4.39e-063221691039098523
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

TOR1AIP2 PPP1R12B NOL6 TTC27 TNRC6B URB2 TNRC6C RAB18 IQCC PROSER3 NINL UQCC1 CEP131 USP54 MOCOS

4.63e-067541691533060197
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SESTD1 ANK3 HECW1 PDE1B WDR7 TNRC6B BCOR MAPK8IP3 TAOK2 NLGN3 NISCH TLN2 CEP131 KIF2A CTNND2 UNC13A EPHA4

5.14e-069631691728671696
Pubmed

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.

MYD88 TICAM1 PRF1 TLR3

5.30e-0624169434526512
Pubmed

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

MYD88 TICAM1 OAS1 IRF1 IKBKE TLR3

5.70e-0691169620588308
Pubmed

Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation.

MYD88 TICAM1 TLR3

6.20e-068169318981140
Pubmed

Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.

MYD88 TICAM1 TLR3

6.20e-068169318322244
Pubmed

The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.

MYD88 TICAM1 TLR3

6.20e-068169321998457
Pubmed

CD103+ Conventional Dendritic Cells Are Critical for TLR7/9-Dependent Host Defense against Histoplasma capsulatum, an Endemic Fungal Pathogen of Humans.

MYD88 TICAM1 TLR3

6.20e-068169327459510
Pubmed

Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.

MYD88 TICAM1 TLR3

6.20e-068169323349877
Pubmed

Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

MYD88 TICAM1 TLR3

6.20e-068169325050810
Pubmed

Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant.

MYD88 TICAM1 TLR3

6.20e-068169327328989
Pubmed

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.

AZI2 CHUK IKBKE

6.20e-068169317568778
Pubmed

β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages.

TLN1 TLN2 VCL

6.20e-068169322017400
Pubmed

A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.

MYD88 TICAM1 TLR3

9.27e-069169319017982
Pubmed

Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies.

MYD88 PRF1 TLR3

9.27e-069169319120481
Pubmed

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.

MYD88 TICAM1 NFKBIA

9.27e-069169312872135
Pubmed

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

MYD88 TICAM1 TLR3

9.27e-069169316210631
Pubmed

Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.

CHUK IKBKE NFKBIA

9.27e-069169320449947
Pubmed

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.

MYD88 TICAM1 TLR3

9.27e-069169330923196
Pubmed

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

MYD88 TICAM1 TLR3

9.27e-069169312855817
Pubmed

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.

MYD88 TICAM1 IKBKE

9.27e-069169318256672
Pubmed

Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production.

MYD88 TICAM1 TLR3

1.32e-0510169331852751
Pubmed

Assembly of the cochlear gap junction macromolecular complex requires connexin 26.

TLN1 TLN2 VCL

1.32e-0510169324590285
Pubmed

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.

MYD88 TICAM1 TLR3

1.32e-0510169317992263
Pubmed

Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.

MYD88 IRF1 TLR3

1.32e-0510169328894449
Pubmed

Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.

MYD88 TICAM1 TLR3

1.32e-0510169320124105
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

NPR1 PPP1R12B TTC27 KIF24 KANSL2 ZNHIT6 MICALL2 TLN1 ANAPC2 BUB1B TLN2 TNKS1BP1 CEP131 TAGLN2 ATL2 ZNHIT2 VCL WDR62

1.45e-0511551691820360068
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

HECW1 TNRC6B TNRC6C MLC1 TLN1 HELZ2 TLN2 TNKS1BP1

1.55e-05225169812168954
Pubmed

DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway.

MYD88 TICAM1 TLR3

1.81e-0511169324391503
Pubmed

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

MYD88 TICAM1 TLR3

1.81e-0511169320975040
Pubmed

The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.

MYD88 TICAM1 TLR3

1.81e-0511169323962979
Pubmed

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

MYD88 TICAM1 APOE

1.81e-0511169320037584
Pubmed

MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.

MYD88 TICAM1 IRF1

1.81e-0511169322896628
Pubmed

Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.

MYD88 TICAM1 TLR3

1.81e-0511169323843525
InteractionIQCC interactions

TNRC6B TNRC6C IQCC PROSER3 NINL

5.96e-08141625int:IQCC
InteractionTBKBP1 interactions

TNRC6B AZI2 TNRC6C DPPA3 IKBKE TNRC6A CTNND2

3.70e-06801627int:TBKBP1
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B TNRC6C TNRC6A CNPY3

9.03e-0625974775
GeneFamilyZinc fingers HIT-type

ZNHIT6 ZNHIT2

4.21e-04697283
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

HECW1 PRF1 CADPS2

9.40e-0436973823
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF24 STARD9 KIF2A

1.92e-0346973622
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7B TLN1 TLN2

2.44e-03509731293
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

MYD88 TICAM1

2.86e-03159721296
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

SESTD1 ANK3 FAT2 DENND2C TNKS1BP1 INAVA TTC22 MUC4 EPHA4

1.53e-081711649adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell390C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FAT2 SIGLEC7 MLC1 ARHGAP31 PRF1 TLN1 ZNHIT2

3.28e-06170164781341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

ANK3 PPP1R12B DYSF RBM20 CTNND2 MYO18B EPHA4

6.36e-0618816476d249fe92d51a19da19ec14bb2262d394255d577
ToppCell10x_3'_v3-spleen_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYO7B IRF1 KDM6B CYRIA PRF1 TLN1 NFKBIA

6.59e-0618916470fe8901e10c619c93b7788792da1706a32102c6e
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VPS4A DEPP1 OAS1 DYSF ARHGAP31 CTNND2 CX3CL1

7.06e-061911647a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 USP11 WWP1 TNRC6C HABP4 TNRC6A KIF2A

7.06e-061911647696921a4f160b6b55698652488ed781e855e5e51
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPR1 DEPP1 OAS1 DYSF ARHGAP31 CTNND2 CX3CL1

7.30e-061921647c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

COMP ZC2HC1C CCDC142 ADAMTS12 IKBKE SERPIND1

7.34e-06126164683f3540683b3b175b10af059ab8898c46eaccc13
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)|Cerebellum / BrainAtlas - Mouse McCarroll V32

COMP ZC2HC1C CCDC142 ADAMTS12 IKBKE SERPIND1

7.34e-0612616466d5075d659dac7b96e6857f8485a7d2c4105d685
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

COMP ZC2HC1C CCDC142 ADAMTS12 IKBKE SERPIND1

7.34e-061261646fd0001a0f3a0a4421f96fd21813c21cf6f01d40e
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

COMP ZC2HC1C CCDC142 ADAMTS12 IKBKE SERPIND1

7.34e-061261646f20424f9baf3c4059cd6b701761e7595400fc47c
ToppCellMild/Remission-B_memory-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 KDM6B CYRIA NFKBIA TAGLN2 CORO7 BBC3

8.08e-0619516473c51f005d8546c570752f5f0ce6b8ac242d3c54b
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RANBP6 DDO SIRT7 TLR3 USP54 GALNT6 ATL2

9.53e-06200164761bae10c8b12196d9cee766897971b81cb897191
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAD1 APOE FIGN ARHGAP31 INAVA TAGLN2

1.29e-051391646a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCellIIH-CD8-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

TRPV1 TCF7 F8 TNKS1BP1 USP54 WDR62

1.70e-0514616467fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYT16 AVIL CEP131 MYO18B RUNDC1 TARBP1

2.30e-05154164616fdafb5c64d2db321554f87129a962d113f1668
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPV1 WDR7 TICAM1 MICA STRC MOCOS

2.48e-051561646d411116d54add2d4fe649a97ac54cb94c085312f
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TCF7 WDR7 USP11 ZC2HC1C TYRO3 AVIL

2.66e-0515816466d2709b387945c015faa223c20d22b52a4082140
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-T_entry|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TCF7 RANBP6 TNRC6C BCOR LCT CD1B

3.06e-051621646a27750117e7f16a0bd07cc5f58a56becb39e800b
ToppCellLPS-IL1RA-Unknown-Endothelial-Monocytes-Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

URB2 SIRT7 TMEM25 HABP4 DENND2C SERPIND1

3.17e-0516316466b11a3ada8725670d0489f404c8c2175ad3904e9
ToppCelldroplet-Liver-Hepatocytes-21m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG PSEN2 NT5E DEPP1 HAAO SERPIND1

3.28e-051641646c9866a289e120be4066e66275c3beb97ba67cca4
ToppCelldroplet-Liver-Hepatocytes-21m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG PSEN2 NT5E DEPP1 HAAO SERPIND1

3.51e-0516616464b63ecedf21285974f0d188979fcdced27bf9ef9
ToppCellCV-Mild-3|Mild / Virus stimulation, Condition and Cluster

ZNF133 SESTD1 PNMT PODXL2 DYSF KANSL2

3.51e-0516616465599f90fc0e15a3670b03187085eba91228390a2
ToppCelldroplet-Liver-Hepatocytes-21m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG PSEN2 NT5E DEPP1 HAAO SERPIND1

3.51e-051661646d6d29b0dc1ef471b1227495f349963ab37f22ec4
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1B APOE CHRNB2 CYRIA MYO18B TMEM26

3.75e-051681646e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR1 ECHDC1 RANBP6 KANSL2 MICALL2 MVD

4.42e-0517316464968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NOL6 FAT2 MICALL2 MUC4 CLUH MVD

4.56e-051741646207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPR1 DEPP1 DYSF F8 ARHGAP31 TMEM26

4.86e-0517616460b3491451be02c18a16cdb875645be47eb867a7f
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PSEN2 LAD1 CD1B CYRIA CLEC4G KIF2A

5.02e-051771646ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOE DYSF DPPA3 CYRIA CLEC4G TMEM26

5.02e-05177164626bad614560609d318bfc9c235a698bca4e1c22c
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DEPP1 URB2 F8 TYRO3 ARHGAP31 ZKSCAN4

5.02e-05177164616197068260fc062bf8b730a51a199887ea580b9
ToppCellSevere-B_memory-3|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 ANK3 NT5E NFKBIA BBC3 EPHA4

5.51e-05180164690b812c5450359b1745b413421b71e291c97086a
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KDM6B LILRB1 CYRIA SIGLEC7 NFKBIA CLEC4G

5.86e-051821646c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCellHSPCs-Ery/Mk_prog.|HSPCs / Lineage and Cell class

APOE KDM6B NFKBIA TAGLN2 GALNT6 BBC3

6.04e-05183164659cfb02143b6b54dfca7560562e064948f0340ca
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 ANK3 WWP1 TNRC6C HABP4 TNRC6A

6.04e-051831646f2ef110bf29b1a8276ef216238363e542db262c1
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

ANK3 PPP1R12B RBM20 CTNND2 MYO18B VCL

6.22e-051841646ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

ANK3 SHC3 USP54 CADPS2 ATL2 MUC4

6.41e-051851646673f0c688ae6984bc8027df2da335787924f4137
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK3 PPP1R12B RBM20 CTNND2 MYO18B VCL

6.41e-0518516466baccb26f999145e51b91d94315bf8d4655bef31
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM6B TLN1 INAVA TAGLN2 CX3CL1 HR

6.61e-051861646bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPR1 DEPP1 DYSF ARHGAP31 CTNND2 CX3CL1

7.01e-05188164673f6ec915934154f435a376cb274b058ff7c5f35
ToppCellHSPCs-Ery/Mk_prog.|World / Lineage and Cell class

APOE KDM6B NFKBIA TAGLN2 GALNT6 BBC3

7.01e-0518816465390089213cd6ee90dcdfd3c3f5b6765376cccf2
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NT5E RTTN KIF24 IQCC PROSER3 WDR62

7.43e-051901646250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellnormal_Lymph_Node-Myeloid_cells-Activated_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

PSEN2 LAD1 DEPP1 CD1B CYRIA MYO18B

7.43e-05190164615978ddd37b521343f88b62dad1643077fc22b2b
ToppCell(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells|World / Stress and Cell class

NPR1 DEPP1 KDM6B F8 ARHGAP31 NFKBIA

7.43e-051901646ff083168d609957d00888f31b3488d6d56c902b4
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAD1 PODXL2 SYT16 NLGN3 ASTN1 INAVA

7.43e-0519016469b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell10x3'2.3-week_17-19-Hematopoietic-MK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TTC27 TLN1 DENND2C KIF2A TAGLN2 VCL

7.43e-05190164664060e4b56ac9989e659c2d5d2a6b6edeba4d8d4
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAD1 PODXL2 SYT16 NLGN3 ASTN1 INAVA

7.43e-051901646d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 HECW1 MYO7B NINL TLN2 BICC1

7.65e-0519116463c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 HECW1 MYO7B NINL TLN2 BICC1

7.65e-0519116461c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 ANK3 TNRC6C HABP4 TNRC6A KIF2A

7.65e-051911646d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

ANK3 PPP1R12B DYSF RBM20 CTNND2 MYO18B

7.65e-0519116465d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

MYD88 OAS1 IRF1 NFKBIA HELZ2 CX3CL1

7.65e-0519116462da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCell10x5'v1-week_14-16-Hematopoietic-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TTC27 TLN1 DENND2C KIF2A TAGLN2 VCL

7.65e-0519116467edc22e7e70697fb22690699efb352577162709b
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COMP HECW1 ADAMTS12 AEBP1 TLN2 BICC1

7.87e-05192164667e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANK3 PPP1R12B RBM20 CTNND2 MYO18B VCL

8.10e-051931646dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPR1 DEPP1 DYSF ARHGAP31 CTNND2 CX3CL1

8.10e-05193164602f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPR1 DEPP1 DYSF ARHGAP31 CTNND2 CX3CL1

8.10e-0519316465122b1ffba42de190061be34ecdc6176f84e56a3
ToppCelllymphoid-NK_cell-NK_cell|World / Lineage, cell class and subclass

IRF1 SIGLEC7 MLC1 PRF1 CORO7 MVD

8.33e-0519416467f5adc18e632109694446b8eb1543cbae62dccbe
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

ANK3 PPP1R12B RBM20 OTOGL MYO18B EPHA4

8.33e-05194164689812fb164065041357bb37a3c2d87028ec3de4e
ToppCell10x3'2.3-week_14-16-Hematopoietic-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TTC27 TLN1 DENND2C KIF2A TAGLN2 VCL

8.33e-051941646216cba1a04b1a24b080322bc950e7fa2dade5ff1
ToppCelllymphoid-NK_cell|World / Lineage, cell class and subclass

IRF1 SIGLEC7 MLC1 PRF1 CORO7 MVD

8.33e-0519416464bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCellMild/Remission-B_memory-0|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 KDM6B CYRIA NFKBIA CORO7 BBC3

8.33e-0519416464866093b50cdf895f06b60684cc3aaa9769aa4dc
ToppCellT/NK_cells-CD56bright_NK_cell|T/NK_cells / Lineage and Cell class

IRF1 SIGLEC7 PRF1 TLN1 NFKBIA TAGLN2

8.57e-051951646d2c8f5c114b1864b509fad449aa4492dfc61113c
ToppCell(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells|(0)_Normal/No_Treatment / Stress and Cell class

NPR1 DEPP1 APOE F8 AEBP1 ARHGAP31

8.57e-051951646e8ab3122f81cb22920becd6611cbd9f00db19d50
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type|TCGA-Adrenal / Sample_Type by Project: Shred V9

RCC1 LENG9 NLGN3 TLR3 MICA MOCOS

8.57e-051951646c3280bb6219e2eff5e24ef45aa2d76479a562122
ToppCell10x3'2.3-week_12-13-Hematopoietic-MK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TTC27 TLN1 DENND2C KIF2A TAGLN2 VCL

8.57e-0519516461e794839a251fbc6e6ce419b4c457ead35a04735
ToppCell3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-|blood / Manually curated celltypes from each tissue

TCF7 IRF1 KDM6B NFKBIA TAGLN2 MVD

8.57e-0519516461470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_4|COVID-19_Severe / Disease condition and Cell class

TICAM1 OAS1 IRF1 KDM6B NFKBIA HELZ2

8.57e-051951646787ea9f38ad8e2a836222ca97f4d927f7e79517d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR1 DYSF F8 ARHGAP31 TMEM26 CX3CL1

8.82e-051961646d323f7dc41380446e5967c69832bea88351a9331
ToppCell10x3'2.3-week_12-13-Hematopoietic-MK-early_MK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TTC27 TLN1 DENND2C KIF2A TAGLN2 VCL

8.82e-051961646fc541e328aed28e84d5b3835169c60da0d64cddc
ToppCell10x5'-Liver-Lymphocytic_NK-NK_CD16|Liver / Manually curated celltypes from each tissue

IRF1 SIGLEC7 MLC1 PRF1 MVD VCL

8.82e-051961646e6d4853ccefbcd45a019cee595811f0474dcc036
ToppCelllymphoid-NK_cell|lymphoid / Lineage, cell class and subclass

IRF1 SIGLEC7 MLC1 PRF1 CORO7 MVD

8.82e-0519616460c7fb03ef782256f61624afc5c1bfaed9f1005fb
ToppCelllymphoid-NK_cell-NK_cell|lymphoid / Lineage, cell class and subclass

IRF1 SIGLEC7 MLC1 PRF1 CORO7 MVD

8.82e-0519616465e6238fe131e349013c60a73c99f84a6be7955ef
ToppCellsevere-dn_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SESTD1 TCF7 PPP1R12B LCT IKBKE KIF2A

8.82e-05196164614baf176bce5750ef50d6838b748caf68c151e05
ToppCellControl-Myeloid-TRAM3|Control / Disease group,lineage and cell class (2021.01.30)

MYD88 OAS1 LILRB1 TLN1 NFKBIA HELZ2

9.06e-051971646733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCellControl-B_memory-3|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 ANK3 NT5E CORO7 BBC3 EPHA4

9.06e-051971646b86385c6c1d52ef4e3d855004d77afab61556978
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MYD88 OAS1 LILRB1 TLN1 NFKBIA HELZ2

9.06e-0519716464416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

OAS1 IRF1 KDM6B GRK2 NFKBIA HELZ2

9.06e-0519716465c33454b10023decd2f5ccda9229b6512659711e
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYD88 OAS1 LILRB1 TLN1 NFKBIA HELZ2

9.06e-0519716460f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYD88 OAS1 LILRB1 TLN1 NFKBIA HELZ2

9.06e-051971646aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCellcontrol-Myeloid-Neutrophils_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

OAS1 IRF1 DYSF NFKBIA HELZ2 TAGLN2

9.06e-0519716468819db1550bf14566c6d33d97f7f83419e867ace
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYD88 OAS1 LILRB1 TLN1 NFKBIA HELZ2

9.06e-051971646e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCellMild/Remission-B_memory-3|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 NFKBIA TAGLN2 CORO7 BBC3 EPHA4

9.32e-05198164644906dbf99ddd53335e2d32082ff7e77d91baaeb
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

IRF1 KDM6B LILRB1 GRK2 TLN1 NFKBIA

9.32e-05198164661ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS1 IRF1 KDM6B GRK2 NFKBIA HELZ2

9.32e-05198164644417089b62056269cac38d3134ff209c05b7007
ToppCellsevere-dn_T|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SESTD1 TCF7 PPP1R12B LCT AEBP1 IKBKE

9.32e-051981646d4f2213af45ada47e6c62675f468ce05692db507
ToppCellnormal_Lymph_Node-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

IRF1 CYRIA SIGLEC7 MLC1 PRF1 NFKBIA

9.32e-05198164675e94298bf03d755fef46df685437d0d29fdbca9
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS1 IRF1 KDM6B GRK2 NFKBIA HELZ2

9.32e-05198164628ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCF7 ANK3 USP11 TNRC6B TNRC6C PRF1

9.32e-051981646a3bd099ef0e606c2da690a6fcf6f79e9360c9c9f
ToppCellMild/Remission-B_memory-3|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TCF7 ANK3 NFKBIA CORO7 BBC3 EPHA4

9.58e-051991646493d043beef70b60338cc199db82592cdc6e635d
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IRF1 KDM6B PRF1 NFKBIA TAGLN2 VCL

9.58e-0519916460902b08e3386e64d7347c186d9ce5b67f2deaabb
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

COMP HECW1 DEPP1 ADAMTS12 AEBP1 BICC1

9.85e-052001646ca777a7d001848f6d01c613ff2bda7e4f3e20521
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRPV1 KIF24 ADAMTS12 NLGN3 USP54 BICC1

9.85e-05200164629054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCellSigmoid-T_cell-Tfh|T_cell / Region, Cell class and subclass

TCF7 ZC2HC1C URB2 HELZ2 TNKS1BP1 ZKSCAN4

9.85e-052001646dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Bdnf_(Deep_layer_pyramidal_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KIF24 CCDC142 AVIL CLEC4G

1.22e-0469164424a480394630385ee51b1dfe1123480107a11403
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Bdnf_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KIF24 CCDC142 AVIL CLEC4G

1.22e-046916441ab1d92e03a31bb1fe87f055d407a81c4d1d81b8
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)|Thalamus / BrainAtlas - Mouse McCarroll V32

MYO7B DEPP1 DYSF DENND2C MOCOS

1.81e-04142164558bfff3284ae21150e4619511bd58622c16c5dde
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--|Thalamus / BrainAtlas - Mouse McCarroll V32

MYO7B DEPP1 DYSF DENND2C MOCOS

1.81e-0414216455fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-|Thalamus / BrainAtlas - Mouse McCarroll V32

MYO7B DEPP1 DYSF DENND2C MOCOS

1.81e-04142164516f9945e835c3506b12d904778560d065a50f059
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

RBM20 TAOK2 ARSD ARHGAP31 PRRT3

1.81e-041421645ae495c8dd733f0fde66bddc281606543f21c0d4b
Drugbeta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; HL60; HT_HG-U133A

TRPV1 ANK3 LAD1 ARFGEF2 ZNF202 RCC1 TAOK2 HABP4 HAAO EPHA4

1.71e-06198163102164_DN
DrugChlormezanone [80-77-3]; Up 200; 14.6uM; MCF7; HT_HG-U133A

NT5E OAS1 NECTIN3 APOE ADAMTS12 GRK2 AEBP1 HAAO TLN2 MUC4

1.79e-06199163105697_UP
Drugcadmium selenide

MYD88 IRF1 CHUK NFKBIA TLR3

4.16e-06341635ctd:C058667
DrugButylparaben [94-26-8]; Up 200; 20.6uM; PC3; HT_HG-U133A

NPR1 OAS1 DDO APOE LILRB1 ARHGEF40 IQCC TLN2 MUC4

1.19e-0519516394647_UP
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A

TCF7 NT5E OAS1 RCC1 DYSF HABP4 IKBKE BBC3 HR

1.19e-0519516394399_DN
DrugFullerenes

MYD88 IRF1 CHUK NFKBIA TLR3

1.21e-05421635ctd:D037741
Drugzinc sulfide

MYD88 IRF1 CHUK NFKBIA TLR3

3.18e-05511635ctd:C031238
DrugTosyllysine Chloromethyl Ketone

IRF1 PRF1 NFKBIA CX3CL1

3.91e-05271634ctd:D014107
Drug2-stearoylglycerol

NT5E APOE

5.09e-0521632CID000079075
DrugAC1Q4UMG

NPR1 TYRO3 RAB18 PRF1

6.00e-05301634CID000093587
Drugcamalexin

NPR1 RAB18 ILVBL MOCOS

6.85e-05311634CID000636970
DrugLY 294002; Down 200; 10uM; PC3; HT_HG-U133A

PSEN2 LAD1 ZNF202 RCC1 PODXL2 URB2 ARHGEF40 IKBKE

7.81e-0519316384460_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A

TCF7 NT5E ZC2HC1C APOE CHRNB2 ADAMTS12 IQCC HR

7.81e-0519316384380_DN
DrugPramoxine hydrochloride [637-58-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

OAS1 RCC1 MAPK8IP3 MLC1 IQCC HAAO CTNND2 ATL2

7.81e-0519316383811_UP
DrugOxyphenbutazone [129-20-4]; Up 200; 12.4uM; PC3; HT_HG-U133A

OAS1 ZC2HC1C KDM6B TAOK2 ARSD MUC4 MVD WDR62

8.10e-0519416384506_UP
DrugSpiramycin [8025-81-8]; Up 200; 4.8uM; MCF7; HT_HG-U133A

HECW1 LILRB1 CHRNB2 SIGLEC7 AEBP1 IQCC VCL HR

8.10e-0519416383938_UP
Drugpoly I

MYD88 NT5E TICAM1 OAS1 IRF1 KY IKBKE TLR3 ZNHIT2

8.28e-052501639CID000000797
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A

TNRC6B RCC1 APOE DYSF CTNND2 ATL2 MVD HR

8.40e-0519516383163_DN
DrugTiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A

ANK3 IRF1 RCC1 MAPK8IP3 HABP4 IKBKE BBC3 HR

8.40e-0519516384686_DN
DrugOxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

TCF7 PSEN2 RCC1 HABP4 TLN1 KIF2A CTNND2 ZKSCAN4

8.40e-0519516386770_DN
DrugHesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A

ZNF133 TNRC6B ZNF202 DDO APOE KDM6B TLN1 BBC3

8.70e-0519616385350_UP
DrugGraveoline [485-61-0]; Down 200; 14.4uM; PC3; HT_HG-U133A

CHRNB2 MAPK8IP3 GRK2 MLC1 PRF1 CTNND2 CADPS2 ATL2

8.70e-0519616383716_DN
DrugHymecromone [90-33-5]; Up 200; 22.8uM; PC3; HT_HG-U133A

TCF7 KDM6B MAPK8IP3 TAOK2 GRK2 PRF1 MUC4 MVD

8.70e-0519616384623_UP
Drugdaunorubicin HCl; Up 200; 1uM; PC3; HT_HG-U133A

ZC2HC1C APOE KDM6B GRK2 PRF1 NFKBIA WDR62 EPHA4

8.70e-0519616387511_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

TNRC6B SIGLEC7 TLN1 TLR3 HAAO ASTN1 ATL2 WDR62

8.70e-0519616382301_UP
DrugMethylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

ARFGEF2 TNRC6B PODXL2 APOE GRK2 ATL2 BBC3 HR

8.70e-0519616383183_DN
DrugPiretanide [55837-27-9]; Up 200; 11uM; PC3; HT_HG-U133A

HECW1 ZC2HC1C CHRNB2 TAOK2 ARSD HAAO TTC22 WDR62

8.70e-0519616384490_UP
DrugGelsemine [509-15-9]; Up 200; 12.4uM; MCF7; HT_HG-U133A

NPR1 ZC2HC1C NECTIN3 APOE MAPK8IP3 GRK2 IQCC PRF1

9.01e-0519716382817_UP
DrugSulfachloropyridazine [80-32-0]; Up 200; 14uM; HL60; HT_HG-U133A

ARFGEF2 PODXL2 CHRNB2 TAOK2 PRF1 AVIL NINL CADPS2

9.01e-0519716382191_UP
DrugCitalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A

PODXL2 CHRNB2 IQCC HAAO ASTN1 TLN2 CTNND2 WDR62

9.01e-0519716384555_UP
DrugTocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PSEN2 RCC1 NECTIN3 GRK2 IKBKE TLN2 ATL2 BBC3

9.01e-0519716383256_DN
DrugPhthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A

COMP OAS1 APOE MAPK8IP3 SIGLEC7 AVIL TLN2 MUC4

9.01e-0519716385249_UP
DrugChlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; HL60; HT_HG-U133A

KDM6B LILRB1 MAPK8IP3 MICALL2 IKBKE TLN1 NABP2 ILVBL

9.34e-0519816381272_DN
DrugMefexamide hydrochloride [3413-64-7]; Down 200; 12.6uM; HL60; HG-U133A

ZNF133 TNRC6B RCC1 AZI2 LILRB1 HAAO ZNHIT2 BBC3

9.34e-0519816381438_DN
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; PC3; HT_HG-U133A

NPR1 OAS1 MAPK8IP3 BBC3 UNC13A MVD VCL WDR62

9.34e-0519816385102_UP
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; PC3; HT_HG-U133A

PPP1R12B DEPP1 MAPK8IP3 TAOK2 PRF1 ATL2 WDR62 EPHA4

9.34e-0519816386622_DN
DrugBenzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; HL60; HT_HG-U133A

TRPV1 APOE AVIL TLN2 KIF2A TTC22 SERPIND1 WDR62

9.67e-0519916386155_UP
Drugnordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A

TCF7 ARFGEF2 RCC1 KDM6B MAPK8IP3 HABP4 GRK2 CTNND2

9.67e-0519916381648_DN
DrugMeclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; PC3; HT_HG-U133A

HECW1 OAS1 KDM6B LILRB1 IQCC TTC22 MUC4 UNC13A

1.00e-0420016384646_UP
DrugPoly I-C

MYD88 TICAM1 OAS1 PRF1 NFKBIA TLR3

1.10e-041051636ctd:D011070
DiseaseALZHEIMER DISEASE 4

PSEN2 APOE

2.78e-0521562606889
DiseaseALZHEIMER DISEASE 4

PSEN2 APOE

2.78e-0521562C1847200
DiseaseAlzheimer disease 4

PSEN2 APOE

2.78e-0521562cv:C1847200
DiseaseSchizophrenia

A1BG PSEN2 ANK3 DDO APOE LILRB1 CHRNB2 ADAMTS12 MLC1 TLR3 ERVK-8 KIF2A CTNND2 ZKSCAN4 CADPS2

7.37e-0588315615C0036341
Diseaseautism spectrum disorder (implicated_via_orthology)

CHRNB2 TAOK2 NLGN3 CTNND2 CADPS2 MOCOS

1.63e-041521566DOID:0060041 (implicated_via_orthology)
DiseasePrimary microcephaly

RBBP8 RTTN WDR62

2.07e-04221563C0431350
DiseaseHerpetic Acute Necrotizing Encephalitis

TICAM1 TLR3

2.75e-0451562C0001338
DiseaseHerpetic meningoencephalitis

TICAM1 TLR3

4.11e-0461562C0019385
Diseaseentorhinal cortical volume

CNPY3 EPHA4

4.11e-0461562EFO_0005092
Diseaseasthma, cardiovascular disease

PNMT RANBP6 IRF1

5.30e-04301563EFO_0000319, MONDO_0004979
DiseasePrimary familial dilated cardiomyopathy

PSEN2 RBM20 VCL

5.30e-04301563cv:C0340427
DiseaseEarly-onset autosomal dominant Alzheimer disease

PSEN2 APOE

5.73e-0471562cv:CN043596
DiseaseHerpes encephalitis

TICAM1 TLR3

5.73e-0471562C0276226
DiseaseSevere Congenital Microcephaly

BUB1B KIF2A WDR62

5.84e-04311563C3853041
DiseaseMalignant neoplasm of breast

MAGEA4 TICAM1 PPP1R12B DEPP1 ARFGEF2 DDO DYSF TMEM25 OTOGL NISCH NFKBIA UQCC1 USP54 ZNHIT2 NLRP8

5.98e-04107415615C0006142
DiseaseMicrolissencephaly

BUB1B KIF2A WDR62

7.04e-04331563C1956147
DiseaseAlzheimer disease

PSEN2 APOE

7.62e-0481562cv:C0002395
DiseaseEmbryonal Rhabdomyosarcoma

BCOR BUB1B

7.62e-0481562C0206656
DiseasePrimary dilated cardiomyopathy

PSEN2 RBM20 VCL

7.69e-04341563cv:C0007193
DiseaseCoronavirus infectious disease (implicated_via_orthology)

MYD88 MUC4

9.76e-0491562DOID:0080599 (implicated_via_orthology)
DiseaseThrombophilia

F8 SERPIND1

9.76e-0491562C0398623
Diseasechronic fatigue syndrome (is_marker_for)

PRF1 CX3CL1

1.22e-03101562DOID:8544 (is_marker_for)
Diseasecolitis (biomarker_via_orthology)

LCT CHUK TLR3

1.43e-03421563DOID:0060180 (biomarker_via_orthology)
Diseaseprimary immunodeficiency disease (is_implicated_in)

MYD88 OAS1 TLR3

1.43e-03421563DOID:612 (is_implicated_in)
DiseaseGM3 ganglioside measurement

APOE CTNND2

1.48e-03111562EFO_0021451
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

TNRC6B TLN2

1.48e-03111562EFO_0004471, EFO_0009131
Diseaseplatelet measurement

RTTN IRF1 DDO KDM6B HABP4 MICA GALNT6

1.49e-033151567EFO_0005036
Diseasedilated cardiomyopathy (is_implicated_in)

APOE RBM20 VCL

1.53e-03431563DOID:12930 (is_implicated_in)
DiseaseFamilial dilated cardiomyopathy

PSEN2 RBM20 VCL

1.64e-03441563C0340427
DiseaseCardiomyopathy

PSEN2 RBM20 VCL

1.98e-03471563cv:C0878544
Diseaseplasma beta-amyloid 1-42 measurement

ANK3 APOE

2.08e-03131562EFO_0005660
Diseaserostral anterior cingulate cortex volume measurement

CYRIA EPHA4

2.08e-03131562EFO_0010327
DiseaseMalformations of Cortical Development

KIF2A WDR62

2.42e-03141562C1955869
DiseaseCortical Dysplasia

KIF2A WDR62

2.42e-03141562C0431380
Diseaseimmature platelet count

RTTN DDO CYRIA TAGLN2

2.46e-031061564EFO_0803544
DiseaseGerm Cell Cancer

DPPA3 BUB1B

2.79e-03151562C0740345
DiseaseEmbryonal Neoplasm

DPPA3 BUB1B

2.79e-03151562C0027654
DiseaseNeoplasms, Germ Cell and Embryonal

DPPA3 BUB1B

2.79e-03151562C0027658
DiseaseGerm cell tumor

DPPA3 BUB1B

2.79e-03151562C0205851
DiseaseNeoplasms, Embryonal and Mixed

DPPA3 BUB1B

2.79e-03151562C0205852
DiseaseCancer, Embryonal

DPPA3 BUB1B

2.79e-03151562C0751364
DiseaseCancer, Embryonal and Mixed

DPPA3 BUB1B

2.79e-03151562C0751365
DiseaseMultiple congenital anomalies

CHUK HAAO

3.59e-03171562C0000772
Diseasecaudal anterior cingulate cortex volume measurement

HECW1 FAT2

3.59e-03171562EFO_0010289
Diseasekeratinocyte carcinoma

TICAM1 CCDC88B CYRIA MICA

3.62e-031181564EFO_0010176
Diseasealcohol use disorder (implicated_via_orthology)

KDM6B CHRNB2 KCNU1 UNC13A HR

3.87e-031951565DOID:1574 (implicated_via_orthology)
Diseasenephrotic syndrome (is_marker_for)

APOE NFKBIA

4.02e-03181562DOID:1184 (is_marker_for)
Diseasetriacylglycerol 56:3 measurement

APOE SYT16

4.02e-03181562EFO_0010430
Diseaseacne

PCNX3 PPP1R12B IRF1 INAVA

4.44e-031251564EFO_0003894
Diseaseneuroimaging measurement

ANK3 TNRC6B APOE DYSF MAPK8IP3 TAOK2 CYRIA PROSER3 TNRC6A NINL UQCC1 TLN2 EPHA4

4.56e-03106915613EFO_0004346
Diseasedocosahexaenoic acid measurement

APOE MICA CTNND2 EPHA4

4.70e-031271564EFO_0007761
Diseaselate-onset Alzheimers disease

SESTD1 ANK3 APOE DYSF CYRIA CTNND2

4.71e-032921566EFO_1001870

Protein segments in the cluster

PeptideGeneStartEntry
RQSNEEGPGEWLTLD

UNC13A

86

Q9UPW8
GAQRDSGLVSQQLPW

URB2

826

Q14146
NELQAGPWNTGRSLE

BUB1B

306

O60566
QAAPGVRGEEEQWAR

BBC3

121

Q9BXH1
LQSWTDNERSIPNDG

AZI2

316

Q9H6S1
GALEPAQQLSSLEGW

LINC00479

16

Q96M42
LQWNAGSGGLPENET

ARSD

116

P51689
IIQWNGPESNSGERL

AVIL

171

O75366
NNEFGTIIDWAPRGQ

ERVK-19

256

O71037
NNEFGTIIDWAPRGQ

ERVK-8

256

Q902F8
QVLQWLSGPGEEQLA

ARHGEF40

791

Q8TER5
LAGQPLQERAQAWGE

APOE

216

P02649
DSDSRPGQELLVAWN

ANAPC2

11

Q9UJX6
QGELVPEAWGLRQEG

CCDC88B

631

A6NC98
GPGVGWENSAETLQE

CCDC88B

1436

A6NC98
ENIQWSIDPGADLSQ

RBBP8

651

Q99708
QGSSEGLRQNVDVWL

HAAO

216

P46952
VNGAKWNPRTGTIND

AEBP1

846

Q8IUX7
DWLFGESQEKQPSQR

DEPP1

106

Q9NTK1
VRNPDQRNTDEDKWG

COMP

331

P49747
ERGQSQLSNPTDDSW

ARFGEF2

1521

Q9Y6D5
GNTIEIQGDDAPSLW

CRYBB1

161

P53674
AQPGGTGEEQWERSR

CCDC142

21

Q17RM4
PWERGDGQDVSARQA

NPR1

291

P16066
QGTQLGDILPNANWT

CD1B

246

P29016
ERWEQQVSAADGKPG

BCOR

1216

Q6W2J9
SESDNWRDRNGIGPG

BICC1

811

Q9H694
SGWENSPLQDDRKIQ

CTNND2

691

Q9UQB3
EGSQLDASDWLNPAQ

ASTN1

431

O14525
DLGGKQWQDSSTQPE

ADAMTS12

1061

P58397
NRLEWRGEGEAPQSL

GRK2

586

P25098
QLGTGQDEDAWSPVE

RCC1

376

P18754
QTPGLWESENQNKGV

RAB18

171

Q9NP72
SEVGPLLQGTNSQWE

RBM20

306

Q5T481
LEQSEWQPTNVDGKG

IRF1

241

P10914
KAGDRVANPEQGLWN

IQCC

71

Q4KMZ1
GGETAQSADPQWEQL

SERPIND1

31

P05546
LSHDTQQWGDVLPDG

MICA

246

Q29983
NQNGWSGDSAPVELI

A1BG

286

P04217
EGQAAEAQSRIPWDS

PODXL2

361

Q9NZ53
NRTEGLLGVWNNNPE

MUC4

4831

Q99102
QPTEGEREIWNQISA

CYRIA

26

Q9H0Q0
SGLVNGRKNESEPWQ

FIGN

96

Q5HY92
NLWISRTQESGDQDP

LAD1

476

O00515
WRQPNEGSSSQEEEG

MAGEA4

81

P43358
AGVNLSGWRPNEDDA

MAPK8IP3

711

Q9UPT6
TPRIWTDLGNNLQGN

NLRP8

801

Q86W28
NERDLLGTVWGGPAN

ECHDC1

281

Q9NTX5
ESTNGAGPWQDELAA

HECW1

761

Q76N89
NWDPQQRGGPVDLTL

CHUK

281

O15111
SFGNWGQDNELLEPL

KY

571

Q8NBH2
IAGAQRRENGPLEWS

IKBKE

246

Q14164
QPSDENWDLTGTRQI

KDM6B

1251

O15054
LEWSSPQNTGGRQDI

EPHA4

346

P54764
EPVLSAEAWLQGANG

CORO7

836

P57737
EQQGWNDSRGPEGML

HABP4

126

Q5JVS0
VEGEGPQNGERKVNW

HR

76

O43593
ARVWAPGDAGQQKES

HR

696

O43593
LQEGQEDGPAGWRAN

MICALL2

576

Q8IY33
ANQPGWRGELQEEGA

PCNX3

551

Q9H6A9
TPEIQRGDWGQQELL

FAT2

4036

Q9NYQ8
EWTLAGTGQEAQAAP

LENG9

196

Q96B70
QWRQPSLDVEVGDPN

PDE1B

461

Q01064
GPLRLQVWDQDSGRD

PRF1

476

P14222
LEGSGQWPQDAEAVQ

NOL6

741

Q9H6R4
WGQGPEKQVAERQQS

KIF24

861

Q5T7B8
TQADPTGRLLDAWQG

MYD88

66

Q99836
LPQTLQDVGGWENET

LCT

1496

P09848
WLNGREEDVGQPRLQ

MVD

66

P53602
RGSEPWKQQLTEDGD

NFKBIA

61

P25963
PQEDALTGSRVWNNS

MOCOS

531

Q96EN8
QGTEGAIKWNEANRP

F8

1546

P00451
ENSGDPWLKGRNSQN

KCNU1

246

A8MYU2
GDPKGWRQLAQEAEA

OAS1

311

P00973
SGLDPNGEQVVWQAS

PDF

191

Q9HBH1
DLDRIQASQWPGVNG

MED26

551

O95402
NNEFGTIIDWAPRGQ

ERVK-7

1016

P63135
TRQKGDWNLSPDAEN

DDO

236

Q99489
PNQIDDLETQWGVGS

KIF2A

571

O00139
DLETQWGVGSSPQRD

KIF2A

576

O00139
SWNGDQDAGPLLVEN

NLGN3

686

Q9NZ94
NQQDGQLEDSPGLWP

GMPPA

201

Q96IJ6
GNDAGWTQISREQVP

ILVBL

546

A1L0T0
RTSGPSEWQLQQEAA

DMRTC2

281

Q8IXT2
NNEFGTIIDWAPRGQ

ERVK-25

256

P61570
NNEFGTIIDWAPRGQ

ERVK-6

256

Q69384
WELAQDQLIRNSGSG

GALNT6

581

Q8NCL4
GPSQAGAEENDWVRL

CNPY3

31

Q9BT09
KDSQSWIGGNNEPLT

ATL2

121

Q8NHH9
PGTEGRLAGQWVEQE

ZNHIT6

86

Q9NWK9
PVDGWQNETSSGNLE

ANK3

4196

Q12955
QAEASRPQWGTQGDF

CADPS2

401

Q86UW7
SQWEGRANGISNPEK

DENND2C

26

Q68D51
DGSPNWDGNSEEILG

ITIH6

1036

Q6UXX5
GEQEPITVDQTWRGD

KANSL2

151

Q9H9L4
TQPQGVLSRNDWRAG

KRBOX1

76

C9JBD0
NNEFGTLIDWAPRGQ

HERVK_113

256

Q902F9
VSWEASRTPQGQLQG

HELZ2

1971

Q9BYK8
EKGATWNVLDDQPRG

CEP131

121

Q9UPN4
EEVFENQTRLPGGQW

DYSF

951

O75923
GPEAARLEWRAQGQA

INAVA

31

Q3KP66
GWTGPLDSQELLQQE

PRRT3

126

Q5FWE3
EQGGEASPQRTWEQQ

DBNL

226

Q9UJU6
WDPSENARIGNQDTK

DPPA3

141

Q6W0C5
DQPRTAGEIWNGGID

OTOGL

1871

Q3ZCN5
GDRPWLRGEDQSEQE

RUNDC1

156

Q96C34
QRPRGDGQDWDAASS

RTTN

321

Q86VV8
SPIQIDGAGRTWQDS

TOR1AIP2

326

Q8NFQ8
RNDLDPRVLSNTGWG

TNRC6C

436

Q9HCJ0
GPSQRDWQNESKEGL

TMEM26

336

Q6ZUK4
GLPDKDRSGVNSWQV

SYT16

376

Q17RD7
QPGRENFQNWLKDGT

TAGLN2

46

P37802
GLQWRSSPAADAQEE

LILRB1

516

Q8NHL6
GDTFGEDWQQTPLRQ

SHC3

386

Q92529
EDWQQTPLRQGSSDI

SHC3

391

Q92529
SQGNLTESWADDNPR

SIGLEC7

406

Q9Y286
PQERSIVGQEEAGTW

TAOK2

856

Q9UL54
LEQAQGSKGDRAWVP

PROSER3

296

Q2NL68
ERGTLGQPLNWEAAT

SIRT7

241

Q9NRC8
SPTDEDTQGPNRLWN

STARD9

3346

Q9P2P6
GREPSQWQSRTENGG

STARD9

4046

Q9P2P6
WGLQEQLQDTARGPE

NINL

691

Q9Y2I6
NEWLSPRAGEGLNSQ

NPFF

86

O15130
RNLIDEDGTNHWPEG

RANBP6

126

O60518
ESPEQQGRSTAWGLQ

STRC

1741

Q7RTU9
PGSEQLRAQWGIGDS

SESTD1

291

Q86VW0
GEWDIVALPGRRNEN

CHRNB2

201

P17787
SPIDERNNGTITWEN

NT5E

396

P21589
QVPGGSQELVQLWND

ANHX

86

E9PGG2
NQGEPNDAWGRENCV

CLEC4G

251

Q6UXB4
PGQTRDWNEELQTTR

CLUH

351

O75153
NRQELGRWLQEEPGA

PNMT

106

P11086
WENSTEVPREAGDGQ

ZNF497

41

Q6ZNH5
NEIGQELTGQEWRGL

TLR3

441

O15455
TTWNTNVGIINEDPG

TRPV1

751

Q8NER1
VGAIPANALDDGQWS

TLN1

2376

Q9Y490
WNQRGSQAPEDKTQE

TICAM1

696

Q8IUC6
NISVWDDVGNLIQPG

NABP2

51

Q9BQ15
PDGALGQRDQSSWQN

TNKS1BP1

1036

Q9C0C2
GGPARASQGREVQWQ

NISCH

1456

Q9Y2I1
QRWIDNPTVDDRGVG

VCL

501

P18206
QGPEDGENTAQWRSQ

PSEN2

36

P49810
EVWTRDPANQSTQGA

ARHGAP31

716

Q2M1Z3
DNGTTPGAEGWRQLL

TMEM201

261

Q5SNT2
QGQGDRALSRTSQWP

UQCC1

31

Q9NVA1
EWKNPESQRGLSGTQ

WDR46

81

O15213
NWPRELKDGNGQESL

TCF7

361

P36402
GGQSRDSDQAPEDRW

MYO18B

496

Q8IUG5
REDETWGRSQQNSGP

ZC2HC1C

301

Q53FD0
LDSEGQEPALRSWGN

WDR62

1271

O43379
DQEKQQQASEGRPWS

ZNF133

126

P52736
QQASEGRPWSDQAEG

ZNF133

131

P52736
QGRTESQWENTEAPV

ZKSCAN4

471

Q969J2
WNRGAGPQLLEELDN

ZNHIT2

131

Q9UHR6
PANAADDGQWSQGLI

TLN2

2381

Q9Y4G6
PGDWSQQDIGTNLVE

TARBP1

1406

Q13395
TTQWEDPRTQGLQNE

WWP1

481

Q9H0M0
GFPTEAERQQWKQEG

TTC27

11

Q6P3X3
LGWLDEQQQPLGGSS

VSIG10L2

446

P0DP72
AQWSQAQLSDGELGR

TTC22

481

Q5TAA0
QGDSSGRLNIWNISD

WDR7

346

Q9Y4E6
ELQSWVRGQRPESGE

ZNF202

101

O95125
PGLDSQWRQIENGES

USP11

76

P51784
GWQVLDATPQEESEG

TGM6

351

O95932
TDLDPRVLSNSGWGQ

TNRC6A

711

Q8NDV7
GTRANLTGWDPQKDL

TYRO3

376

Q06418
LSSGWGELEPQIDGQ

TMEM25

21

Q86YD3
GELEPQIDGQTWAER

TMEM25

26

Q86YD3
ALLQAWGGQPEALSE

ZFTA

321

C9JLR9
TDLDPRVLSNTGWGQ

TNRC6B

611

Q9UPQ9
WQSLETGQNQSDPVG

TNRC6B

1746

Q9UPQ9
PEENAPSEGQRVWGQ

CX3CL1

236

P78423
QQSSLEGGDRPLSWE

USP54

1186

Q70EL1
NNDGTLVLGATNIPW

VPS4A

261

Q9UN37
QGASWDTQNGPQERL

MLC1

336

Q15049
GLLASENWTLGQNDR

MYO7B

1536

Q6PIF6
AGEGQQPWGRSLDEE

PPP1R12B

701

O60237
RLDGQWPDGLLASDN

NECTIN3

306

Q9NQS3