Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	D-glucuronate catabolic process to D-xylulose 5-phosphate	XYLB AKR1A1	9.42e-05	5	64	2	GO:0019640
GeneOntologyBiologicalProcess	glucuronate catabolic process	XYLB AKR1A1	9.42e-05	5	64	2	GO:0006064
GeneOntologyBiologicalProcess	xylulose 5-phosphate metabolic process	XYLB AKR1A1	1.41e-04	6	64	2	GO:0051167
GeneOntologyBiologicalProcess	xylulose 5-phosphate biosynthetic process	XYLB AKR1A1	1.41e-04	6	64	2	GO:1901159
Domain	DUF2075	SLFN13 SLFN11	3.35e-05	3	63	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	3.35e-05	3	63	2	PF09848
Domain	-	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	8.45e-05	679	63	10	3.30.160.60
Domain	zf-C2H2	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	1.00e-04	693	63	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	1.01e-04	694	63	10	IPR013087
Domain	KRAB	ZNF845 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551	1.97e-04	358	63	7	PS50805
Domain	KRAB	ZNF845 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551	1.97e-04	358	63	7	PF01352
Domain	AlbA_2	SLFN13 SLFN11	2.33e-04	7	63	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	2.33e-04	7	63	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	2.33e-04	7	63	2	IPR007421
Domain	KRAB	ZNF845 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551	2.37e-04	369	63	7	SM00349
Domain	KRAB	ZNF845 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551	2.41e-04	370	63	7	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	2.49e-04	775	63	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	2.54e-04	777	63	10	PS00028
Domain	Znf_C2H2-like	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	3.08e-04	796	63	10	IPR015880
Domain	Znf_C2H2	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	3.37e-04	805	63	10	IPR007087
Domain	ZnF_C2H2	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	3.47e-04	808	63	10	SM00355
Domain	zf-C2H2_6	ZNF845 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	6.54e-04	314	63	6	PF13912
Domain	TIL	MUC2 OTOG	7.23e-04	12	63	2	PF01826
Domain	C8	MUC2 OTOG	7.23e-04	12	63	2	PF08742
Domain	Septin	SEPTIN5 SEPTIN4	8.53e-04	13	63	2	PF00735
Domain	Unchr_dom_Cys-rich	MUC2 OTOG	8.53e-04	13	63	2	IPR014853
Domain	G_SEPTIN_dom	SEPTIN5 SEPTIN4	8.53e-04	13	63	2	IPR030379
Domain	C8	MUC2 OTOG	8.53e-04	13	63	2	SM00832
Domain	G_SEPTIN	SEPTIN5 SEPTIN4	8.53e-04	13	63	2	PS51719
Domain	TIL_dom	MUC2 OTOG	9.93e-04	14	63	2	IPR002919
Domain	Septin	SEPTIN5 SEPTIN4	9.93e-04	14	63	2	IPR016491
Domain	VWD	MUC2 OTOG	1.30e-03	16	63	2	SM00216
Domain	VWF_type-D	MUC2 OTOG	1.30e-03	16	63	2	IPR001846
Domain	VWFD	MUC2 OTOG	1.30e-03	16	63	2	PS51233
Domain	VWD	MUC2 OTOG	1.30e-03	16	63	2	PF00094
Domain	VWC_out	MUC2 OTOG	1.85e-03	19	63	2	SM00215
Domain	CT	MUC2 OTOG	2.48e-03	22	63	2	SM00041
Domain	Cys_knot_C	MUC2 OTOG	3.20e-03	25	63	2	IPR006207
Domain	CTCK_2	MUC2 OTOG	3.20e-03	25	63	2	PS01225
Domain	ASX_HYDROXYL	EYS CELSR3 MATN2	4.69e-03	100	63	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	EYS CELSR3 MATN2	5.51e-03	106	63	3	IPR000152
Domain	LAM_G_DOMAIN	EYS CELSR3	7.28e-03	38	63	2	PS50025
Domain	Laminin_G_2	EYS CELSR3	8.04e-03	40	63	2	PF02210
Domain	EGF_CA	EYS CELSR3 MATN2	8.12e-03	122	63	3	SM00179
Domain	EGF_3	EYS CELSR3 MATN2 OTOG	8.15e-03	235	63	4	PS50026
Domain	EGF-like_Ca-bd_dom	EYS CELSR3 MATN2	8.49e-03	124	63	3	IPR001881
Domain	VWF_dom	MUC2 OTOG	8.84e-03	42	63	2	IPR001007
Domain	EGF	EYS CELSR3 MATN2	8.87e-03	126	63	3	PF00008
Domain	LamG	EYS CELSR3	9.67e-03	44	63	2	SM00282
Domain	EGF-like_dom	EYS CELSR3 MATN2 OTOG	9.93e-03	249	63	4	IPR000742
Pathway	REACTOME_FORMATION_OF_XYLULOSE_5_PHOSPHATE	XYLB AKR1A1	1.04e-04	5	46	2	M27544
Pathway	REACTOME_FORMATION_OF_XYLULOSE_5_PHOSPHATE	XYLB AKR1A1	1.04e-04	5	46	2	MM15263
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	3.44e-06	2	65	2	37833372
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	3.44e-06	2	65	2	29563550
Pubmed	The novel human platelet septin SEPT8 is an interaction partner of SEPT4.	SEPTIN5 SEPTIN4	1.03e-05	3	65	2	15116257
Pubmed	Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.	MET AOPEP	1.03e-05	3	65	2	28077801
Pubmed	Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.	SEPTIN5 SEPTIN4	1.03e-05	3	65	2	15214843
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	1.03e-05	3	65	2	38875319
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ANKRD44 SEPTIN5 AOPEP EHMT1 RNF213 G2E3 XYLB FBXO21 RECK PLEKHM1 HNRNPU BICD1	1.78e-05	1489	65	12	28611215
Pubmed	SEPT5_v2 is a parkin-binding protein.	SEPTIN5 SEPTIN4	2.06e-05	4	65	2	14559152
Pubmed	Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.	SEPTIN5 SEPTIN4	3.43e-05	5	65	2	17296554
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	3.43e-05	5	65	2	18355440
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	3.43e-05	5	65	2	29528433
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	3.43e-05	5	65	2	24089532
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN13 SLFN11	5.13e-05	6	65	2	9846487
Pubmed	The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification.	NR5A1 SMAD9	5.13e-05	6	65	2	22723422
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	TES CELSR3	7.18e-05	7	65	2	17937400
Pubmed	Differential localization of septins in the mouse brain.	SEPTIN5 SEPTIN4	7.18e-05	7	65	2	11064363
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN13 SLFN11	7.18e-05	7	65	2	15351786
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN13 SLFN11	9.56e-05	8	65	2	19619625
Pubmed	Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.	SEPTIN5 SEPTIN4	1.23e-04	9	65	2	18809578
Pubmed	The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.	SEPTIN5 SEPTIN4	1.53e-04	10	65	2	11739749
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	EHMT1 NR5A1	2.24e-04	12	65	2	28949961
Pubmed	USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.	SLFN13 KDM7A SLFN11	3.53e-04	73	65	3	30224337
Pubmed	Localization of septin proteins in the mouse cochlea.	SEPTIN5 SEPTIN4	4.06e-04	16	65	2	22575789
Pubmed	Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.	MET NR5A1	4.59e-04	17	65	2	35568059
Pubmed	Genetic determinants of P wave duration and PR segment.	MET XYLB	4.59e-04	17	65	2	24850809
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ISLR2 CELSR3 EHMT1 G2E3 CACNA1G KDM7A	4.65e-04	529	65	6	14621295
Pubmed	Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme.	MET SMAD9	7.06e-04	21	65	2	22282599
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ISLR2 TES EHMT1 RNF213 ZNF740 XYLB SLFN11 ZNF574	1.10e-03	1116	65	8	31753913
Pubmed	Quality control by DNA repair.	GTF2H3 SMUG1	1.26e-03	28	65	2	10583946
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	COPA MATN2 POF1B HNRNPU	1.68e-03	271	65	4	26816005
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF845 FCGRT ZNF233 ZNF470 ZNF761 ZNF551 ZNF574	1.47e-03	1192	65	7	chr19q13
Cytoband	17q22	SEPTIN4 CACNA1G	1.80e-03	44	65	2	17q22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF845 ZBTB17 ZNF740 ZNF233 ZNF470 ZNF761 ZNF317 ZNF443 ZNF551 ZNF574	1.02e-05	718	46	10	28
GeneFamily	Schlafen family	SLFN13 SLFN11	1.32e-04	7	46	2	1110
GeneFamily	Septins	SEPTIN5 SEPTIN4	4.85e-04	13	46	2	732
GeneFamily	Calcium voltage-gated channel subunits	CACNA1G CACNG4	1.98e-03	26	46	2	253
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	ANKRD44 ZNF845 TES SEPTIN5 FCGRT AOPEP RNF213 CACNA1G XYLB RECK SMAD9	7.67e-06	744	61	11	Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	ANKRD44 ZNF845 ZBTB17 FCGRT AOPEP MATN2 RAPGEF4 RNF213 CACNA1G SMAD9	3.82e-05	726	61	10	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#3	ZNF845 ZBTB17 RAPGEF4 RNF213 CACNA1G SMAD9	6.18e-05	238	61	6	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000	ANKRD44 ZNF845 ZBTB17 FCGRT RAPGEF4 RNF213 CACNA1G CACNG4 KDM7A RECK SMAD9	9.01e-05	973	61	11	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#2	ANKRD44 ZNF845 SEPTIN5 FCGRT AOPEP RNF213 CACNA1G RECK SMAD9	9.90e-05	655	61	9	Facebase_RNAseq_e9.5_Olfactory Placode_2500_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1	ANKRD44 SEPTIN5 FCGRT AOPEP RNF213 CACNA1G	1.12e-04	265	61	6	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000_k-means-cluster#2	ANKRD44 ZNF845 FCGRT AOPEP RNF213 CACNA1G	1.82e-04	290	61	6	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000_K2
Drug	Kanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; PC3; HT_HG-U133A	TNFRSF25 CELSR3 PIM2 KDM7A XYLB CAPN15 BICD1	1.33e-06	200	63	7	4625_DN
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	MET ZBTB17 CELSR3 EHMT1 CACNG4 HNRNPU	1.47e-05	191	63	6	5234_DN
Drug	Fenbendazole [43210-67-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A	MET TNFRSF25 GTF2H3 COPA HNRNPU ZNF574	1.47e-05	191	63	6	3888_DN
Drug	Iodixanol [92339-11-2]; Down 200; 2.6uM; MCF7; HT_HG-U133A	PIM2 EHMT1 CACNG4 FBXO21 ZNF574 BICD1	1.61e-05	194	63	6	4848_DN
Drug	staurosporine; Down 200; 0.01uM; MCF7; HG-U133A	TES COPA EHMT1 CACNG4 MUC2 BICD1	1.70e-05	196	63	6	425_DN
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	CCNJL MET TNFRSF25 PIM2 CAPN15 BICD1	1.91e-05	200	63	6	3418_UP
Disease	Premature ovarian failure	NR5A1 POF1B	8.48e-05	7	60	2	cv:C0085215
Disease	lysophosphatidylethanolamine 18:0 measurement	LIPC MATN2	4.20e-04	15	60	2	EFO_0010367
Disease	Glioblastoma	MET TES RECK	5.66e-04	79	60	3	C0017636
Disease	ischemia (biomarker_via_orthology)	LIPC MUC2	6.09e-04	18	60	2	DOID:326 (biomarker_via_orthology)
Disease	Giant Cell Glioblastoma	MET TES RECK	6.77e-04	84	60	3	C0334588
Disease	Ovarian Failure, Premature	NR5A1 POF1B	8.33e-04	21	60	2	C0085215
Disease	Glioblastoma Multiforme	MET TES RECK	1.52e-03	111	60	3	C1621958

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGHQHCQKYSVPLCI	CAPZA3	51	Q96KX2
AQLYHHVCLCNNETP	BICD1	516	Q96G01
SHCQLCPAARHLAVY	CCNJL	51	Q8IV13
NFRHVGVCSHMEYPC	AOPEP	371	Q8N6M6
LQLYHNPFHCGCGLV	ISLR2	176	Q6UXK2
GHHTNCREYCQAIFR	RECK	156	O95980
CQRYYHRGHVDPAND	MCOLN1	166	Q9GZU1
NRHPKAYLHVQCDCT	CAPN15	991	O75808
HHQPFYNVLVEDGSC	FBXO21	546	O94952
DIDLYHCPNCAVLHG	KDM7A	76	Q6ZMT4
EHNCAHFCINIPGSY	MATN2	246	O00339
QHLCYCGVTFHGICQ	EYS	456	Q5T1H1
HHYCCIVQHAGLAQP	FCGRT	271	P55899
SCIQHYHDNCLPTIF	PDCL2	151	Q8N4E4
FCGPNEIDHYFCDVH	OR4S2	166	Q8NH73
CHCRLHGHLYTPGQE	MUC2	351	Q02817
PHVLCHNCAVEFNFG	HNRNPU	446	Q00839
QPGCHFLELYRHIAQ	LIPC	251	P11150
KCGRTPLHYAAANCH	ANKRD44	436	Q8N8A2
EVLQCQPQHYHCYHQ	POF1B	21	Q8WVV4
SYHFPCGLQRECIFQ	G2E3	101	Q7L622
FYHADCHLEPVRCQA	CACNA1G	556	O43497
CIEGIYKGHCFRINH	CACNG4	71	Q9UBN1
RGHYNNVSCAVFHPR	COPA	246	P53621
FEELEYHEPVCRQHC	MARF1	966	Q9Y4F3
YHEPVCRQHCSNKDF	MARF1	971	Q9Y4F3
HCHGQGKYPCLQVFV	KCNMB3	116	Q9NPA1
RFYLRQPQHSDCCEH	LCE7A	66	P0DV60
NGQCHCKEFHYRPRG	CELSR3	2056	Q9NYQ7
HCEAHRILYVCENQP	SLFN13	621	Q68D06
FYGNVSRFINHHCEP	EHMT1	1191	Q9H9B1
VCEAPRQHQLYHCQR	FAM166A	166	Q6J272
CDIHCEANQEYEHPR	OTOG	2736	Q6ZRI0
NNVRCLQHFYGPNHE	MET	381	P08581
QHVYHCDLCTQRGFI	PLEKHM1	986	Q9Y4G2
KFHPNLLHQICLCGY	RAPGEF4	46	Q8WZA2
LCHYPHCGDKFQQLL	NR5A1	406	Q13285
PCYVKNHAVVCQGCH	TES	351	Q9UGI8
NRVHCCLYFISPFGH	SEPTIN4	251	O43236
NRVHCCLYFISPFGH	SEPTIN5	151	Q99719
QAPVCGFPCNHRHLF	SPATA31A6	1236	Q5VVP1
RCFFGQVVAAIQHCH	PIM2	141	Q9P1W9
HLPRRLYCGHTFCQA	RNF224	36	P0DH78
HCEAHRILYVCENQP	SLFN11	621	Q7Z7L1
RFRHFCYQEAHGPQE	PGBD1	46	Q96JS3
NCNYQHGFHPATVCK	SMAD9	361	O15198
ECHPYLAQNELIAHC	AKR1A1	186	P14550
HPDTCANNCIFYKNH	CCDC15	896	Q0P6D6
HCRLHTGEKPYQCNE	ZNF845	541	Q96IR2
DLGCLVLHCPHQSFY	PIGV	136	Q9NUD9
ECLQHFLFHCGVINP	RNF213	2196	Q63HN8
CNCGRHHIHYVIPYD	TMEM240	51	Q5SV17
NLACHRRCHTGENPY	ZNF761	256	Q86XN6
FRECGYCNINPHHSK	nan	106	Q96MF0
YVPLCCFHQDSRAHL	TMEM39A	196	Q9NV64
LVHAQHFPYRCQECG	ZNF574	571	Q6ZN55
LEGHIFCNPVDSQHY	XYLB	316	O75191
HQRVHSGERPYQCCE	ZNF551	381	Q7Z340
HQRCHTGEKPYECNV	ZNF470	611	Q6ECI4
HRFACNTCPYVHNIT	POLR3K	21	Q9Y2Y1
FYCQPCLDCGALHRH	TNFRSF25	136	Q93038
RNLCGQPEVFFHHCF	SMUG1	146	Q53HV7
FRAHQCQYVHPCVHV	USP41	6	Q3LFD5
HSGEKPYVCIHCQRQ	ZBTB17	496	Q13105
PYACQQCGKAFHHLG	ZNF443	336	Q9Y2A4
LPRHQCFHIGEKCYR	ZNF233	301	A6NK53
HSGEKPYQCERCHQC	ZNF740	151	Q8NDX6
ERPYECHDCGKAFQH	ZNF317	331	Q96PQ6
PVHVDYRAACFCHRN	GTF2H3	246	Q13889