Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel activity	ASIC1 CNGB1 SCN1A SCN2A	2.26e-06	52	36	4	GO:0005272
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	ASIC1 CNGB1 SCN1A SCN2A	2.47e-04	171	36	4	GO:0015081
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A	2.84e-04	14	36	2	GO:0031402
GeneOntologyMolecularFunction	S100 protein binding	AGER AHNAK	3.27e-04	15	36	2	GO:0044548
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A	4.23e-04	17	36	2	GO:0099508
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A	9.99e-04	26	36	2	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A	9.99e-04	26	36	2	GO:0031420
GeneOntologyMolecularFunction	channel activity	GJA8 ASIC1 CNGB1 SCN1A SCN2A	2.37e-03	525	36	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GJA8 ASIC1 CNGB1 SCN1A SCN2A	2.39e-03	526	36	5	GO:0022803
GeneOntologyMolecularFunction	gated channel activity	ASIC1 CNGB1 SCN1A SCN2A	2.97e-03	334	36	4	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	ASIC1 CNGB1 SCN1A SCN2A	3.27e-03	343	36	4	GO:0005261
GeneOntologyCellularComponent	cell-cell contact zone	TJP1 CADM4 SCN1A AHNAK SCN2A	6.42e-07	94	37	5	GO:0044291
GeneOntologyCellularComponent	anchoring junction	MCAM HSPG2 GJA8 TJP1 CADM4 SCN1A AHNAK CDH13 SCN2A AKAP12	5.17e-06	976	37	10	GO:0070161
GeneOntologyCellularComponent	T-tubule	SCN1A AHNAK SCN2A AHNAK2	1.13e-05	79	37	4	GO:0030315
GeneOntologyCellularComponent	cell-cell junction	GJA8 TJP1 CADM4 SCN1A AHNAK CDH13 SCN2A	6.86e-05	591	37	7	GO:0005911
GeneOntologyCellularComponent	intercalated disc	TJP1 SCN1A SCN2A	2.36e-04	68	37	3	GO:0014704
GeneOntologyCellularComponent	sarcolemma	SCN1A AHNAK SCN2A AHNAK2	3.45e-04	190	37	4	GO:0042383
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A	4.08e-04	17	37	2	GO:0001518
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A	5.68e-04	20	37	2	GO:0033268
GeneOntologyCellularComponent	costamere	AHNAK AHNAK2	6.89e-04	22	37	2	GO:0043034
GeneOntologyCellularComponent	focal adhesion	MCAM HSPG2 AHNAK CDH13 AKAP12	9.21e-04	431	37	5	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	MCAM HSPG2 AHNAK CDH13 AKAP12	1.04e-03	443	37	5	GO:0030055
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A	1.20e-03	29	37	2	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A	1.20e-03	29	37	2	GO:0034706
GeneOntologyCellularComponent	gap junction	GJA8 TJP1	1.95e-03	37	37	2	GO:0005921
GeneOntologyCellularComponent	plasma membrane protein complex	HSPG2 GJA8 SCN1A AHNAK CDH13 SCN2A	2.36e-03	785	37	6	GO:0098797
GeneOntologyCellularComponent	cell surface	MCAM ASIC1 TJP1 CRLF2 AGER CDH13 DNAI2	2.98e-03	1111	37	7	GO:0009986
GeneOntologyCellularComponent	membrane protein complex	HSPG2 GJA8 SPG7 CNGB1 SCN1A AHNAK CDH13 SCN2A	4.05e-03	1498	37	8	GO:0098796
GeneOntologyCellularComponent	axon	SPG7 CNGB1 AGER SCN1A SCN2A KIF1C	4.42e-03	891	37	6	GO:0030424
HumanPheno	Photosensitive myoclonic seizure	SCN1A SCN2A	7.73e-05	8	9	2	HP:0001327
HumanPheno	Cyanotic episode	SCN1A SCN2A	7.73e-05	8	9	2	HP:0200048
HumanPheno	Limited neck range of motion	SCN1A SCN2A	1.51e-04	11	9	2	HP:0000466
HumanPheno	Epilepsia partialis continua	SCN1A SCN2A	1.81e-04	12	9	2	HP:0012847
HumanPheno	Focal automatism seizure	SCN1A SCN2A	1.81e-04	12	9	2	HP:0032898
HumanPheno	Generalized cerebral atrophy/hypoplasia	SCN1A SCN2A	2.14e-04	13	9	2	HP:0007058
HumanPheno	Aortopulmonary collateral arteries	SCN1A SCN2A	2.88e-04	15	9	2	HP:0031834
HumanPheno	Photosensitive tonic-clonic seizure	SCN1A SCN2A	2.88e-04	15	9	2	HP:0007207
HumanPheno	Facial tics	SCN1A SCN2A	2.88e-04	15	9	2	HP:0011468
HumanPheno	Dysgenesis of the hippocampus	SCN1A SCN2A	3.29e-04	16	9	2	HP:0025101
HumanPheno	Complex febrile seizure	SCN1A SCN2A	3.29e-04	16	9	2	HP:0011172
HumanPheno	Frontal balding	GJA8 SCN1A	3.29e-04	16	9	2	HP:0002292
HumanPheno	Atypical absence status epilepticus	SCN1A SCN2A	3.72e-04	17	9	2	HP:0011151
HumanPheno	Focal motor status epilepticus	SCN1A SCN2A	3.72e-04	17	9	2	HP:0032663
HumanPheno	Focal emotional seizure with laughing	SCN1A SCN2A	3.72e-04	17	9	2	HP:0010821
HumanPheno	Visually-induced seizure	SCN1A SCN2A	4.18e-04	18	9	2	HP:0020216
HumanPheno	Generalized non-convulsive status epilepticus without coma	SCN1A SCN2A	4.18e-04	18	9	2	HP:0032860
HumanPheno	Focal emotional seizure	SCN1A SCN2A	4.18e-04	18	9	2	HP:0025613
HumanPheno	Postural instability	SPG7 SCN1A SCN2A	4.57e-04	93	9	3	HP:0002172
HumanPheno	Nystagmus	HSPG2 GJA8 SPG7 CNGB1 SCN1A SCN2A KIF1C	5.19e-04	1102	9	7	HP:0000639
HumanPheno	Spastic ataxia	SPG7 KIF1C	5.19e-04	20	9	2	HP:0002497
HumanPheno	Non-convulsive status epilepticus without coma	SCN1A SCN2A	5.19e-04	20	9	2	HP:0032671
HumanPheno	Talipes valgus	SCN1A SCN2A	5.73e-04	21	9	2	HP:0004684
HumanPheno	Abnormal involuntary eye movements	HSPG2 GJA8 SPG7 CNGB1 SCN1A SCN2A KIF1C	5.87e-04	1123	9	7	HP:0012547
HumanPheno	Reflex seizure	SCN1A SCN2A	6.29e-04	22	9	2	HP:0020207
HumanPheno	Tibial torsion	SCN1A SCN2A	6.89e-04	23	9	2	HP:0100694
HumanPheno	Gait ataxia	SPG7 SCN1A SCN2A KIF1C	7.12e-04	263	9	4	HP:0002066
HumanPheno	Focal hemiclonic seizure	SCN1A SCN2A	8.15e-04	25	9	2	HP:0006813
HumanPheno	Simple febrile seizure	SCN1A SCN2A	9.52e-04	27	9	2	HP:0011171
HumanPheno	Limited knee extension	SCN1A SCN2A	9.52e-04	27	9	2	HP:0003066
HumanPheno	Status epilepticus without prominent motor symptoms	SCN1A SCN2A	9.52e-04	27	9	2	HP:0031475
HumanPheno	Focal aware seizure	SCN1A SCN2A	1.02e-03	28	9	2	HP:0002349
HumanPheno	Status epilepticus with prominent motor symptoms	SCN1A SCN2A	1.10e-03	29	9	2	HP:0032658
HumanPheno	Progressive gait ataxia	SCN1A SCN2A	1.18e-03	30	9	2	HP:0007240
HumanPheno	Progressive ataxia	SCN1A SCN2A	1.18e-03	30	9	2	HP:0001329
HumanPheno	Cogwheel rigidity	SCN1A SCN2A	1.34e-03	32	9	2	HP:0002396
HumanPheno	Fasciculations	TSPYL1 SCN1A KIF1C	1.39e-03	136	9	3	HP:0002380
HumanPheno	Obsessive-compulsive trait	SCN1A SCN2A	1.42e-03	33	9	2	HP:0008770
HumanPheno	Generalized clonic seizure	SCN1A SCN2A	1.51e-03	34	9	2	HP:0011169
HumanPheno	Calcaneovalgus deformity	SCN1A SCN2A	1.51e-03	34	9	2	HP:0001848
HumanPheno	Deformed tarsal bones	SCN1A SCN2A	1.60e-03	35	9	2	HP:0008119
HumanPheno	Limitation of knee mobility	SCN1A SCN2A	1.60e-03	35	9	2	HP:0010501
HumanPheno	Limitation of neck motion	SCN1A SCN2A	1.69e-03	36	9	2	HP:0005986
HumanPheno	Disturbance of facial expression	SCN1A SCN2A	1.69e-03	36	9	2	HP:0005324
HumanPheno	Abnormal neck physiology	SCN1A SCN2A	1.69e-03	36	9	2	HP:0025669
MousePheno	abnormal nervous system electrophysiology	DGKG HSPG2 INSYN1 CNGB1 SCN1A SCN2A	3.16e-05	329	27	6	MP:0002272
Domain	Na_trans_cytopl	SCN1A SCN2A	5.39e-05	6	36	2	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A	5.39e-05	6	36	2	IPR024583
Domain	C2-set_2	MCAM CADM4 AGER	6.67e-05	41	36	3	PF08205
Domain	CD80_C2-set	MCAM CADM4 AGER	6.67e-05	41	36	3	IPR013162
Domain	Na_channel_asu	SCN1A SCN2A	1.61e-04	10	36	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A	1.61e-04	10	36	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A	1.61e-04	10	36	2	PF06512
Domain	IGc2	MCAM HSPG2 CADM4 AGER	1.05e-03	235	36	4	SM00408
Domain	Ig_sub2	MCAM HSPG2 CADM4 AGER	1.05e-03	235	36	4	IPR003598
Domain	IG	MCAM HSPG2 MADCAM1 CADM4 AGER	1.20e-03	421	36	5	SM00409
Domain	Ig_sub	MCAM HSPG2 MADCAM1 CADM4 AGER	1.20e-03	421	36	5	IPR003599
Domain	Ion_trans_dom	CNGB1 SCN1A SCN2A	1.37e-03	114	36	3	IPR005821
Domain	Ion_trans	CNGB1 SCN1A SCN2A	1.37e-03	114	36	3	PF00520
Domain	-	MCAM HSPG2 CRLF2 MADCAM1 CADM4 AGER	1.53e-03	663	36	6	2.60.40.10
Domain	Ig-like_fold	MCAM HSPG2 CRLF2 MADCAM1 CADM4 AGER	2.11e-03	706	36	6	IPR013783
Domain	IG_LIKE	MCAM HSPG2 MADCAM1 CADM4 AGER	2.37e-03	491	36	5	PS50835
Domain	PDZ	TJP1 AHNAK AHNAK2	2.51e-03	141	36	3	PF00595
Domain	Ig-like_dom	MCAM HSPG2 MADCAM1 CADM4 AGER	2.63e-03	503	36	5	IPR007110
Domain	PDZ	TJP1 AHNAK AHNAK2	2.87e-03	148	36	3	SM00228
Domain	-	TJP1 AHNAK AHNAK2	2.99e-03	150	36	3	2.30.42.10
Domain	PDZ	TJP1 AHNAK AHNAK2	3.04e-03	151	36	3	PS50106
Domain	PDZ	TJP1 AHNAK AHNAK2	3.10e-03	152	36	3	IPR001478
Domain	V-set	MCAM HSPG2 CADM4	5.29e-03	184	36	3	PF07686
Domain	Channel_four-helix_dom	SCN1A SCN2A	5.39e-03	57	36	2	IPR027359
Domain	-	SCN1A SCN2A	5.39e-03	57	36	2	1.20.120.350
Domain	Ig_I-set	HSPG2 CADM4 AGER	5.78e-03	190	36	3	IPR013098
Domain	ig	MCAM HSPG2 AGER	5.78e-03	190	36	3	PF00047
Domain	Immunoglobulin	MCAM HSPG2 AGER	5.78e-03	190	36	3	IPR013151
Domain	I-set	HSPG2 CADM4 AGER	5.78e-03	190	36	3	PF07679
Domain	Ig_V-set	MCAM HSPG2 CADM4	6.57e-03	199	36	3	IPR013106
Domain	Ig_2	HSPG2 AGER	8.71e-03	73	36	2	PF13895
Domain	IQ	SCN1A SCN2A	1.06e-02	81	36	2	SM00015
Domain	EF-hand_7	DGKG CRACR2A	1.17e-02	85	36	2	PF13499
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A	1.30e-02	90	36	2	IPR000048
Domain	IQ	SCN1A SCN2A	1.38e-02	93	36	2	PS50096
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.10e-06	2	37	2	29649454
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.10e-06	2	37	2	26311622
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	1.10e-06	2	37	2	15007166
Pubmed	Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.	GJA8 TJP1	1.10e-06	2	37	2	21965293
Pubmed	AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.	AHNAK AHNAK2	1.10e-06	2	37	2	20833135
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.10e-06	2	37	2	10827969
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.10e-06	2	37	2	15249644
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.10e-06	2	37	2	19694741
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.10e-06	2	37	2	21377452
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.10e-06	2	37	2	1317301
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.10e-06	2	37	2	33096315
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.10e-06	2	37	2	31439038
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.10e-06	2	37	2	30693367
Pubmed	Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.	SCN1A SCN2A	3.30e-06	3	37	2	19270815
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	3.30e-06	3	37	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	3.30e-06	3	37	2	32185219
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A	3.30e-06	3	37	2	12610651
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	3.30e-06	3	37	2	32005694
Pubmed	Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.	SCN1A SCN2A	3.30e-06	3	37	2	25155934
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	AHNAK AHNAK2	3.30e-06	3	37	2	21940993
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A	3.30e-06	3	37	2	17928448
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A	3.30e-06	3	37	2	23859570
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A	3.30e-06	3	37	2	14973256
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A	3.30e-06	3	37	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A	3.30e-06	3	37	2	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A	3.30e-06	3	37	2	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A	3.30e-06	3	37	2	28518218
Pubmed	AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.	AHNAK AHNAK2	6.60e-06	4	37	2	17185750
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A	6.60e-06	4	37	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A	6.60e-06	4	37	2	35031483
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	SCN1A SCN2A	6.60e-06	4	37	2	26637798
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A	6.60e-06	4	37	2	29578003
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A	6.60e-06	4	37	2	21156207
Pubmed	Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1).	GJA8 TJP1	6.60e-06	4	37	2	12808044
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A	6.60e-06	4	37	2	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A	6.60e-06	4	37	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A	1.10e-05	5	37	2	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A	1.10e-05	5	37	2	8812438
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A	1.10e-05	5	37	2	24337656
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	MCAM HSPG2 AHNAK CDH13 AKAP12	1.25e-05	285	37	5	21423176
Pubmed	Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration.	TJP1 AHNAK AKAP12	1.63e-05	46	37	3	35022314
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A	1.65e-05	6	37	2	23652591
Pubmed	CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.	MCAM TJP1	2.30e-05	7	37	2	28827364
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	AHNAK AHNAK2	2.30e-05	7	37	2	23415230
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A	2.30e-05	7	37	2	25818041
Pubmed	Claudin-4 localization in epithelial ovarian cancer.	MCAM AHNAK AKAP12	2.65e-05	54	37	3	36237976
Pubmed	JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.	GJA8 TJP1	3.95e-05	9	37	2	38095908
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A	3.95e-05	9	37	2	15746173
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A	3.95e-05	9	37	2	16382098
Pubmed	Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.	HSPG2 TJP1	3.95e-05	9	37	2	18816447
Pubmed	Common variants associated with general and MMR vaccine-related febrile seizures.	SCN1A SCN2A	4.93e-05	10	37	2	25344690
Pubmed	Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.	SCN1A SCN2A	4.93e-05	10	37	2	20602612
Pubmed	Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.	INHBB SCN1A SCN2A	6.03e-05	71	37	3	8751373
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A	7.22e-05	12	37	2	8169823
Pubmed	Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.	HSPG2 TJP1	7.22e-05	12	37	2	22072575
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A	7.22e-05	12	37	2	30175250
Pubmed	PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity.	HSPG2 TJP1	8.53e-05	13	37	2	37936982
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A	8.53e-05	13	37	2	15123669
Pubmed	Deletion of astroglial connexins weakens the blood-brain barrier.	HSPG2 TJP1	9.94e-05	14	37	2	22472609
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A	1.15e-04	15	37	2	9726281
Pubmed	N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis.	GJA8 TJP1	1.15e-04	15	37	2	28552735
Pubmed	Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.	GJA8 TJP1	1.15e-04	15	37	2	30562487
Pubmed	Ontogeny of stromal organizer cells during lymph node development.	HSPG2 MADCAM1	1.31e-04	16	37	2	20237296
Pubmed	The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis.	HSPG2 TJP1	1.31e-04	16	37	2	21350012
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	HSPG2 TJP1	1.31e-04	16	37	2	11564885
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	MCAM TJP1 AHNAK AHNAK2	1.56e-04	256	37	4	33397691
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	HSPG2 CDYL AHNAK AHNAK2	2.79e-04	298	37	4	30737378
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	MCAM TJP1 AHNAK AKAP12 AHNAK2	3.23e-04	568	37	5	37774976
Pubmed	Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.	MEA1 SKOR2	3.52e-04	26	37	2	35165395
Pubmed	GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression.	TJP1 CDH13	3.52e-04	26	37	2	38281222
Pubmed	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	RNF150 AHNAK	3.80e-04	27	37	2	23144326
Pubmed	ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus.	TJP1 AKAP12	4.09e-04	28	37	2	33046507
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	MCAM HSPG2 CDH13	5.07e-04	146	37	3	27068509
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TJP1 AHNAK AKAP12 AHNAK2	5.69e-04	360	37	4	33111431
Pubmed	Lung epithelial branching program antagonizes alveolar differentiation.	HSPG2 TJP1	5.69e-04	33	37	2	24058167
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	SCN1A CDH13	7.56e-04	38	37	2	22952603
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	MCAM PLEKHA6 CADM4 AKAP12	1.02e-03	421	37	4	36976175
Interaction	CLDN4 interactions	MCAM GJA8 TJP1 AHNAK AKAP12	2.01e-07	74	36	5	int:CLDN4
Cytoband	2q24.3	SCN1A SCN2A	7.53e-05	16	37	2	2q24.3
GeneFamily	Immunoglobulin like domain containing	MCAM HSPG2 MADCAM1 CADM4 AGER	1.51e-05	193	30	5	594
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MCAM CADM4 AGER	3.91e-05	40	30	3	592
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A	9.51e-05	9	30	2	1203
GeneFamily	PDZ domain containing	TJP1 AHNAK AHNAK2	2.00e-03	152	30	3	1220
Coexpression	LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES	MCAM DGKG TJP1 CDH13 AKAP12	2.54e-06	155	37	5	M39246
Coexpression	LAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES	PITPNC1 TJP1 CDH13 AKAP12	4.13e-05	137	37	4	M39241
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	PLEKHA6 PITPNC1 ASIC1 CNGB1 CDH13 SCN2A	4.40e-05	465	37	6	M39066
CoexpressionAtlas	dev gonad_e11.5_M_ReproVasc_Flk_k-means-cluster#3_top-relative-expression-ranked_500	MCAM HSPG2 PITPNC1 TJP1 MADCAM1	3.76e-05	226	36	5	gudmap_dev gonad_e11.5_M_ReproVasc_Flk_k3_500
CoexpressionAtlas	dev gonad_e11.5_M_ReproVasc_Flk_top-relative-expression-ranked_500	MCAM HSPG2 PITPNC1 TJP1 MADCAM1 KIF1C	6.29e-05	414	36	6	gudmap_dev gonad_e11.5_M_ReproVasc_Flk_500
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_500	MCAM HSPG2 PITPNC1 TJP1 MADCAM1 KIF1C	6.37e-05	415	36	6	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_500
CoexpressionAtlas	dev gonad_e11.5_M_ReproVasc_Flk_k-means-cluster#4_top-relative-expression-ranked_1000	MCAM HSPG2 PITPNC1 TJP1 MADCAM1 KIF1C	2.05e-04	514	36	6	gudmap_dev gonad_e11.5_M_ReproVasc_Flk_k4_1000
CoexpressionAtlas	BM Top 100 - midbrain	KANK4 SCN1A SCN2A	2.36e-04	71	36	3	BM Top 100 - midbrain
CoexpressionAtlas	BM Top 100 - dorsal root ganglia	KANK4 AKAP12 AHNAK2	2.36e-04	71	36	3	BM Top 100 - dorsal root ganglia
CoexpressionAtlas	kidney_adult_Podocyte_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	TJP1 CADM4 AHNAK KIF1C	2.98e-04	191	36	4	gudmap_kidney_adult_Podocyte_MafB_k1_1000
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	MCAM HSPG2 PITPNC1 TJP1 MADCAM1 KIF1C	3.58e-04	570	36	6	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k3_1000
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#2_top-relative-expression-ranked_1000	TMEM119 PLEKHA6 AHNAK SCN2A AHNAK2	3.73e-04	369	36	5	gudmap_kidney_adult_RenalCapsule_k2_1000
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_top-relative-expression-ranked_1000	MCAM HSPG2 PITPNC1 TJP1 MADCAM1 SCN2A KIF1C	4.24e-04	831	36	7	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_1000
CoexpressionAtlas	Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5	HSPG2 TJP1 MADCAM1	4.75e-04	90	36	3	GSM777032_100
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ZNF821 ZSCAN2 CDH13 AKAP12	3.50e-07	177	37	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	facs-Aorta-Heart-18m-Endothelial-aortic_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANK4 PITPNC1 TJP1 AHNAK CDH13	5.38e-07	193	37	5	7b7fecd332d3c99b8810bd7e14ab33aab46f2ffd
ToppCell	facs-Aorta-Heart-18m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANK4 PITPNC1 TJP1 AHNAK CDH13	5.38e-07	193	37	5	7170cbaef0ba1b65cab89c5d4ce525e6c04e4418
ToppCell	facs-Aorta-Heart-18m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANK4 PITPNC1 TJP1 AHNAK CDH13	5.38e-07	193	37	5	348a89bbf5fe7f7c875300c9ec3cb245c37e1308
ToppCell	ASK428-Endothelial-Endothelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	MCAM HSPG2 INHBB TJP1 CDH13	5.80e-07	196	37	5	b1a81eddb91fb462360692b7b0a3ba4a947eac40
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DGKG ASIC1 SCN1A CDH13 SCN2A	6.25e-07	199	37	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM HSPG2 PITPNC1 INHBB AKAP12	6.25e-07	199	37	5	6fb81388c5045e81c3849a7136bdff3f953f044e
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM DGKG RNF150 CDH13 AKAP12	6.41e-07	200	37	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM HSPG2 PITPNC1 INHBB AKAP12	6.41e-07	200	37	5	a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DGKG ASIC1 SCN1A SCN2A	8.19e-06	155	37	4	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	HSPG2 ASIC1 AGER AHNAK	9.28e-06	160	37	4	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	MCAM DGKG CDH13 AKAP12	9.51e-06	161	37	4	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	MCAM DGKG CDH13 AKAP12	1.10e-05	167	37	4	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RNF150 CRLF2 MADCAM1 DNAI2	1.21e-05	171	37	4	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 CADM4 AGER AHNAK2	1.41e-05	178	37	4	a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 CADM4 AGER AHNAK2	1.41e-05	178	37	4	b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell	COPD-Stromal-SMC\|World / Disease state, Lineage and Cell class	MCAM DGKG CDH13 AKAP12	1.44e-05	179	37	4	b2709537ec1b46457ab85261f4cdd354e60a8b29
ToppCell	Endothelial-A-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	MCAM HSPG2 CDH13 AHNAK2	1.44e-05	179	37	4	138fd6ba6bdbd0ad01c574168addf720b67a0fea
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	MCAM DGKG CDH13 AKAP12	1.48e-05	180	37	4	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKG CDYL SCN1A SCN2A	1.48e-05	180	37	4	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DGKG AHNAK SCN2A AKAP12	1.51e-05	181	37	4	beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM TJP1 CDH13 AKAP12	1.61e-05	184	37	4	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KANK4 HSPG2 AGER AHNAK	1.61e-05	184	37	4	c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KANK4 HSPG2 AGER AHNAK	1.61e-05	184	37	4	1ed558a88215b248431c524ea16f13d9022ae98c
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 INHBB CDH13	1.64e-05	185	37	4	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKG CDYL SCN1A SCN2A	1.64e-05	185	37	4	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	facs-Trachea-nan-24m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNC1 INHBB CNGB1 CDH13	1.64e-05	185	37	4	dec60254204014083ff3b4aec0cc75410950a486
ToppCell	facs-Trachea-nan-24m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNC1 INHBB CNGB1 CDH13	1.64e-05	185	37	4	201465dc0d7aa0336a36d37805cae1155a5adfe1
ToppCell	facs-Trachea-nan-24m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNC1 INHBB CNGB1 CDH13	1.64e-05	185	37	4	334f006c3ef33338ff8d649309d3f448733a3a99
ToppCell	COPD-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	MCAM DGKG TJP1 AKAP12	1.68e-05	186	37	4	8adfd2d1fda4e8aecc95192ea627bf7ed5214b8d
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-VSMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MCAM DGKG CDH13 AKAP12	1.68e-05	186	37	4	c7885fd6dc7dc8fffc96f0112c51a365cf8a8f80
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	MCAM DGKG CDH13 AKAP12	1.71e-05	187	37	4	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKG CDYL SCN1A SCN2A	1.71e-05	187	37	4	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM PITPNC1 TJP1 AKAP12	1.71e-05	187	37	4	52ffd4be374e329ac8d321063f061b826d252956
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	MCAM HSPG2 PITPNC1 INHBB	1.71e-05	187	37	4	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	IPF-Stromal-SMC\|World / Disease state, Lineage and Cell class	MCAM DGKG CDH13 AKAP12	1.75e-05	188	37	4	b66264e8f8d536ed2beec31e6746c687718f239b
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.75e-05	188	37	4	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	IPF-Stromal-SMC\|IPF / Disease state, Lineage and Cell class	MCAM DGKG CDH13 AKAP12	1.75e-05	188	37	4	e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCell	droplet-Lung-LUNG-30m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM PITPNC1 TJP1 AKAP12	1.79e-05	189	37	4	25db316f66cee53774bb2b286cc457b37353356c
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 CDH13 AKAP12	1.79e-05	189	37	4	37ce47abd6f96df04d35a4a6189d007bef5ccc94
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 CDH13 AKAP12	1.79e-05	189	37	4	b55324cb365a827d071952709bbf0e8ef8c313de
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 CDH13 AKAP12	1.79e-05	189	37	4	62e46d59d3b89d4566b595c704d8b02f1ea9060b
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.82e-05	190	37	4	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.82e-05	190	37	4	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM PITPNC1 TJP1 AKAP12	1.82e-05	190	37	4	e64b191f928935484e2c993d7f8af0572a617a3a
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 AHNAK CDH13	1.82e-05	190	37	4	b7fc451e160e31dc898b122de844b501f587db67
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 AHNAK CDH13	1.82e-05	190	37	4	83cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 AHNAK CDH13	1.82e-05	190	37	4	5f440d4b334d66d419c03bd828f7d93f16c1ce67
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PITPNC1 INHBB TJP1 AKAP12	1.86e-05	191	37	4	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM DGKG CADM4 AKAP12	1.86e-05	191	37	4	6e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM PITPNC1 INHBB CDH13	1.86e-05	191	37	4	79b399496bd7322a1d53c43378f48695fd09a5d9
ToppCell	facs-Trachea-24m-Endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM PITPNC1 INHBB CDH13	1.86e-05	191	37	4	9c6d5d045781c6506ae80e318427ef1e0d87f45c
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 TJP1 MADCAM1 CDH13	1.86e-05	191	37	4	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	droplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM DGKG CADM4 AKAP12	1.86e-05	191	37	4	3ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM PITPNC1 INHBB CDH13	1.86e-05	191	37	4	1b1e943709d0c3283a980c7c965ef1f110506a29
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM DGKG CADM4 AKAP12	1.86e-05	191	37	4	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 AHNAK CDH13	1.90e-05	192	37	4	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MCAM PITPNC1 INHBB AKAP12	1.90e-05	192	37	4	c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	MCAM INHBB CDH13 AKAP12	1.90e-05	192	37	4	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	facs-BAT-Fat-3m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.94e-05	193	37	4	e340064cd146deac03f2d0fd43e2e218bb6057c9
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 TJP1 AKAP12	1.94e-05	193	37	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	MCAM KANK4 HSPG2 TMEM119	1.94e-05	193	37	4	b6f5a85210e60798205eaf5884cdb540f549d08a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	MCAM KANK4 HSPG2 TMEM119	1.94e-05	193	37	4	e1de67ddada87229f5db0ec193a6da8745a86a64
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TMEM119 INHBB TJP1	1.94e-05	193	37	4	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 INHBB MADCAM1 AKAP12	1.94e-05	193	37	4	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 TJP1 AKAP12	1.94e-05	193	37	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	facs-BAT-Fat-3m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.94e-05	193	37	4	a211b386fd0fb9da9937361d29d90925a72c9715
ToppCell	facs-BAT-Fat-3m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TJP1 CDH13 AKAP12	1.94e-05	193	37	4	3086c33f4d6fab66966818737f95ae4d6b2615b0
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	MCAM DGKG CDH13 AKAP12	1.94e-05	193	37	4	9104b572d9c3c99080e4b7455993fbb944bf117d
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 TJP1 AKAP12	1.94e-05	193	37	4	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	356C-Endothelial_cells-Endothelial-A_(Artery)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MCAM HSPG2 INHBB TJP1	1.98e-05	194	37	4	2e5b195e02dcd5e9432b9a98b22e0478e65b9ba2
ToppCell	(5)_Epithelial_cells-(5)_Epi_basal\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	KANK4 RNF150 INHBB AKAP12	1.98e-05	194	37	4	b887b2ff19b76bd93c67f9a24762efae816efd45
ToppCell	356C-Endothelial_cells-Endothelial-A_(Artery)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MCAM HSPG2 INHBB TJP1	1.98e-05	194	37	4	b6b5b0ab506b05a005ba8a05a3c7f4c725ba9200
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|World / Lineage and Cell class	HSPG2 TMEM119 AHNAK AHNAK2	1.98e-05	194	37	4	c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	MCAM DGKG RNF150 CDH13	1.98e-05	194	37	4	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 INHBB AKAP12	2.02e-05	195	37	4	f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCell	droplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCAM PITPNC1 TJP1 AKAP12	2.02e-05	195	37	4	27d1f228103ff5d8941aa8a8d15726cd09298a30
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	HSPG2 PITPNC1 INHBB AKAP12	2.02e-05	195	37	4	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Mesenchymal_cells-Stromal_fibro.\|World / Lineage and Cell class	KANK4 HSPG2 AHNAK AKAP12	2.02e-05	195	37	4	69723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 INHBB AKAP12	2.02e-05	195	37	4	ea1b00805391dca8be0883b635768b296369919a
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 INHBB AKAP12	2.02e-05	195	37	4	126f46dd15dddcf5701144718bb8ba1ce84b2d1d
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM PITPNC1 TJP1 CDH13	2.02e-05	195	37	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	droplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCAM HSPG2 INHBB AKAP12	2.02e-05	195	37	4	85df110f753f58ab017018c54ee454edb4428e29
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DGKG ASIC1 SCN1A SCN2A	2.06e-05	196	37	4	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 PITPNC1 INHBB CDH13	2.06e-05	196	37	4	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	MCAM DGKG HSPG2 AKAP12	2.06e-05	196	37	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 RNF150 AGER AHNAK	2.06e-05	196	37	4	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSPG2 RNF150 AGER AHNAK	2.06e-05	196	37	4	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	TMEM119 AHNAK CDH13 AHNAK2	2.06e-05	196	37	4	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	Epithelial-Epithelial-A_(AT1)\|Epithelial / shred on cell class and cell subclass (v4)	HSPG2 TJP1 AGER AHNAK	2.06e-05	196	37	4	41b21a18125cc95bc8adde3369e4abd029cf137d
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DGKG ASIC1 SCN1A SCN2A	2.06e-05	196	37	4	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 INHBB TJP1 AKAP12	2.10e-05	197	37	4	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM DGKG CDH13 AKAP12	2.10e-05	197	37	4	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM KANK4 RNF150 CDH13	2.10e-05	197	37	4	f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM DGKG CDH13 AKAP12	2.10e-05	197	37	4	bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell	mLN-T_cell-Th1\|T_cell / Region, Cell class and subclass	MCAM TSPYL1 AHNAK CDH13	2.10e-05	197	37	4	5e39a49dddef04469ff2b615d755ddf6a926e58e
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 INHBB TJP1 AKAP12	2.10e-05	197	37	4	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	(2)_Fibroblasts-(24)_Fibro-5\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	HSPG2 TMEM119 AHNAK CDH13	2.10e-05	197	37	4	83a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MCAM DGKG CDH13 AKAP12	2.14e-05	198	37	4	705118a5db366b43ffd3389c60e4cb392ad3f2e6
ToppCell	distal-3-Endothelial-Bronchial_Vessel_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HSPG2 CDYL CADM4 AHNAK2	2.14e-05	198	37	4	f701d06e3d7fd2192afae3698c5ec3c355e96da3
Computational	Genes upregulated in subsets of cells of a given type within various tumors	MCAM HSPG2 CDH13	1.57e-04	50	23	3	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_1
Disease	spleen volume	PLEKHA6 TJP1 KIF1C	1.99e-05	43	36	3	EFO_0600047
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	3.03e-05	7	36	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	3.03e-05	7	36	2	C0751057
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	5.18e-05	9	36	2	C3502809
Disease	Febrile Convulsions	SCN1A SCN2A	5.18e-05	9	36	2	C0009952
Disease	cutaneous melanoma, hair color	SPG7 AHNAK AKAP12	6.00e-05	62	36	3	EFO_0000389, EFO_0003924
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A	6.47e-05	10	36	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A	6.47e-05	10	36	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A	9.48e-05	12	36	2	DOID:0060170 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	SKOR2 KIF1C	9.48e-05	12	36	2	DOID:863 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.12e-04	13	36	2	C0751122
Disease	chronic kidney disease (is_implicated_in)	AGER AKAP12	1.30e-04	14	36	2	DOID:784 (is_implicated_in)
Disease	MMR-related febrile seizures	SCN1A SCN2A	1.50e-04	15	36	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	1.72e-04	16	36	2	C0393706
Disease	childhood aggressive behaviour measurement	INHBB SCN1A CDH13	1.76e-04	89	36	3	EFO_0007663
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.19e-04	18	36	2	HP_0002373
Disease	carotid artery disease (is_marker_for)	HSPG2 AGER	2.44e-04	19	36	2	DOID:3407 (is_marker_for)
Disease	brain ischemia (biomarker_via_orthology)	TJP1 AGER AKAP12	2.64e-04	102	36	3	DOID:2316 (biomarker_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	3.29e-04	22	36	2	DOID:2030 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	CDYL SCN1A SCN2A	1.03e-03	163	36	3	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELAPVPEEGGVEQLQ	C16orf86	221	Q6ZW13
DDGQEETPEIIEQIP	AKAP12	136	Q02952
TEEATPVQEVEGGVP	AKAP12	1016	Q02952
PVQEVEGGVPDIEEQ	AKAP12	1021	Q02952
VDIEGPDVNIEGPEG	AHNAK	2546	Q09666
GPQVDIDVPDVGVQG	AHNAK	3001	Q09666
VQIVDDEGNVLPPGE	ACSM5	401	Q6NUN0
EEEEVSDQGVQGQIP	CRACR2A	496	Q9BSW2
EGPVPLEVIVIDQND	CDH13	226	P55290
QPSPEEDQVVEEGEE	DNAI2	576	Q9GZS0
EEVQLVVEPEGGAVA	AGER	236	Q15109
VPEETGQDPALEVEQ	HSPG2	1111	P98160
GEQEVEEEEVGLPPE	INSYN1	206	Q2T9L4
AQALGPEVQEEEEEP	MADCAM1	161	Q13477
QELAVVPVFVDPGEE	INHBB	256	P09529
QPDGEVVVTLEPCEG	KIF1C	551	O43896
GAEQESGPEEPLVVQ	CRLF2	301	Q9HC73
EVIPREEVENGDQVP	DGKG	561	P49619
DPVEQGQEDTVAPEV	CDYL	221	Q9Y232
VGAQEVEGEGPPAEE	GJA8	326	P48165
NPVVEVREQAVEGGE	CADM4	126	Q8NFZ8
ELVQEGAEPPEGVVK	KANK4	226	Q5T7N3
GEAEQPAPELVEVEV	MCAM	26	P43121
VVQDTDPIPQEGDVI	RNF150	381	Q9ULK6
DPEQEEVELAPVGDG	MEA1	76	Q16626
EETEETQQPPLGGEE	SPG7	776	Q9UQ90
TVDIGAPVEEQPVVE	SCN1A	1156	P35498
QVDVELLEGPVPEGA	AHNAK2	3536	Q8IVF2
EEEEVGGVQPVSIQA	ASIC1	6	P78348
PGGQVEPDLVLEEVE	CNGB1	296	Q14028
VVPIGEGDSVDVPQD	PLEKHA6	966	Q9Y2H5
VQEAVLQEDGPESEP	ZSCAN2	41	Q7Z7L9
PGDSEIEEGEIVQPE	SCAF1	386	Q9H7N4
EVEEQPPEGEEIEVA	TSPYL1	191	Q9H0U9
VDIGAPAEGEQPEVE	SCN2A	1146	Q99250
GEGVEVVQNEPFEDP	PITPNC1	36	Q9UKF7
EQEVDVEGHKPPEGE	SKOR2	741	Q2VWA4
IIIPQGAIPEGVEQE	TJP1	1656	Q07157
TEQPVGGNEVVEHEV	ZNF821	91	O75541
DQEVQGHGVPVETPE	TMEM119	216	Q4V9L6