Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytosolic large ribosomal subunit	RPL39P5 RPL39 RPL39L	2.79e-04	59	45	3	GO:0022625
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	4.06e-04	14	45	2	GO:0060091
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	4.06e-04	14	45	2	GO:0097732
GeneOntologyCellularComponent	ribosomal subunit	RPL39P5 RPL39 RPL39L MRPS25	7.96e-04	194	45	4	GO:0044391
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	1.02e-03	22	45	2	GO:0032426
GeneOntologyCellularComponent	large ribosomal subunit	RPL39P5 RPL39 RPL39L	2.09e-03	118	45	3	GO:0015934
GeneOntologyCellularComponent	cytosolic ribosome	RPL39P5 RPL39 RPL39L	2.41e-03	124	45	3	GO:0022626
GeneOntologyCellularComponent	ribosome	RPL39P5 RPL39 RPL39L MRPS25	2.57e-03	267	45	4	GO:0005840
Domain	Ribosomal_L39_CS	RPL39 RPL39L	5.68e-06	2	45	2	IPR020083
Domain	Mediator_Med25	MED25 PTOV1	5.68e-06	2	45	2	IPR021394
Domain	Ribosomal_L39	RPL39 RPL39L	5.68e-06	2	45	2	PF00832
Domain	Ribosomal_L39e_dom	RPL39 RPL39L	5.68e-06	2	45	2	IPR023626
Domain	Ribosomal_L39	RPL39 RPL39L	5.68e-06	2	45	2	IPR000077
Domain	Med25	MED25 PTOV1	5.68e-06	2	45	2	PF11232
Domain	-	RPL39 RPL39L	5.68e-06	2	45	2	1.10.1620.10
Domain	RIBOSOMAL_L39E	RPL39 RPL39L	5.68e-06	2	45	2	PS00051
Domain	ARM-type_fold	USP34 JUP INF2 FMNL2 XPOT INTS1	1.53e-04	339	45	6	IPR016024
Domain	Drf_GBD	INF2 FMNL2	2.02e-04	9	45	2	PF06371
Domain	FH3_dom	INF2 FMNL2	2.02e-04	9	45	2	IPR010472
Domain	GTPase-bd	INF2 FMNL2	2.02e-04	9	45	2	IPR010473
Domain	Drf_FH3	INF2 FMNL2	2.02e-04	9	45	2	PF06367
Domain	Drf_FH3	INF2 FMNL2	2.02e-04	9	45	2	SM01139
Domain	Drf_GBD	INF2 FMNL2	2.02e-04	9	45	2	SM01140
Domain	GBD/FH3_dom	INF2 FMNL2	3.08e-04	11	45	2	IPR014768
Domain	GBD_FH3	INF2 FMNL2	3.08e-04	11	45	2	PS51232
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH11	5.07e-04	14	45	2	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH11	5.07e-04	14	45	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH11	5.07e-04	14	45	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH11	5.07e-04	14	45	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH11	5.07e-04	14	45	2	PF08393
Domain	MT	DNAH3 DNAH11	5.07e-04	14	45	2	PF12777
Domain	AAA_8	DNAH3 DNAH11	5.07e-04	14	45	2	PF12780
Domain	AAA_5	DNAH3 DNAH11	5.07e-04	14	45	2	PF07728
Domain	DHC_fam	DNAH3 DNAH11	5.84e-04	15	45	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DNAH11	5.84e-04	15	45	2	IPR004273
Domain	FH2	INF2 FMNL2	5.84e-04	15	45	2	PS51444
Domain	Dynein_heavy	DNAH3 DNAH11	5.84e-04	15	45	2	PF03028
Domain	FH2_Formin	INF2 FMNL2	5.84e-04	15	45	2	IPR015425
Domain	FH2	INF2 FMNL2	5.84e-04	15	45	2	PF02181
Domain	FH2	INF2 FMNL2	5.84e-04	15	45	2	SM00498
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.79e-06	2	47	2	34910522
Pubmed	PTOV1 antagonizes MED25 in RAR transcriptional activation.	MED25 PTOV1	1.79e-06	2	47	2	21110951
Pubmed	Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity.	RPL39 RPL39L	1.79e-06	2	47	2	34428590
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.79e-06	2	47	2	11687802
Pubmed	Human transcription factor protein interaction networks.	LENG8 JUP KAT2B RPL39 LDB1 RBBP5 WDR33 MRPS25 LRRC49 XPOT DDX10	2.41e-06	1429	47	11	35140242
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	5.36e-06	3	47	2	30801007
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.07e-05	4	47	2	18849963
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.78e-05	5	47	2	24920589
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH3 DNAH11	3.74e-05	7	47	2	9256245
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	4.98e-05	8	47	2	21165971
Pubmed	Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.	MED25 LENG8 INTS1	5.47e-05	54	47	3	16239144
Pubmed	Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.	USP34 JUP RPL39	7.50e-05	60	47	3	26472337
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	KAT2B RBBP5	9.75e-05	11	47	2	24051374
Pubmed	Complex transcription and splicing of odorant receptor genes.	OR2H1 OR2H2	9.75e-05	11	47	2	12637542
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	9.75e-05	11	47	2	31776257
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	9.75e-05	11	47	2	31448880
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	USP34 JUP LDB1 WDR33	1.04e-04	180	47	4	35198878
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR2H1 OR2H2	1.38e-04	13	47	2	14506126
Pubmed	Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects.	JUP XIRP2	1.61e-04	14	47	2	17766470
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	INF2 FMNL2	1.61e-04	14	47	2	26272686
Pubmed	MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.	MED25 PTOV1	1.61e-04	14	47	2	17641689
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DNAH11	1.61e-04	14	47	2	9373155
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KAT2B RBBP5	2.40e-04	17	47	2	26180087
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	2.40e-04	17	47	2	20856818
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DNAH3 ZNF484 XIRP2 DNAH11	2.79e-04	233	47	4	37704626
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	LDB1 TBCE C2CD2L	4.51e-04	110	47	3	27889896
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PLXNA4 DNAH3 JUP FMNL2 RBBP5 INTS1	4.52e-04	736	47	6	29676528
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	LENG8 LDB1 RBBP5 WDR33	4.74e-04	268	47	4	33640491
Pubmed	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	PLXNA4 FMNL2	7.59e-04	30	47	2	19401682
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 RECK INTS1 MTNR1A	9.40e-04	322	47	4	26514267
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	RBBP5 WDR33 INTS1	1.03e-03	146	47	3	23892456
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	LENG8 WDR33 INTS1 DDX10	1.16e-03	341	47	4	32971831
Pubmed	Functional proteomics mapping of a human signaling pathway.	SECISBP2 JUP LDB1 ZNF484 FMNL2	1.19e-03	591	47	5	15231748
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	STRC STRCP1	1.22e-03	38	47	2	38346162
Interaction	RPL39L interactions	RPL39 CCNDBP1 RPL39L	9.68e-08	5	44	3	int:RPL39L
Cytoband	15q15.3	STRC STRCP1	3.03e-04	25	47	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STRC CCNDBP1 STRCP1	4.70e-04	147	47	3	chr15q15
GeneFamily	Dyneins, axonemal	DNAH3 DNAH11	4.32e-04	17	33	2	536
GeneFamily	L ribosomal proteins	RPL39 RPL39L	3.90e-03	51	33	2	729
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.27e-06	2	45	2	DOID:0110471 (implicated_via_orthology)
Disease	proprotein convertase subtilisin/kexin type 9 measurement	TDRD15 DDX10	5.15e-04	22	45	2	EFO_0009312
Disease	urate measurement, bone density	PLXNA4 THAP9 MRPS25 DNAH11 DDX10	2.44e-03	619	45	5	EFO_0003923, EFO_0004531
Disease	unipolar depression, sex interaction measurement	JUP DNAH11	2.77e-03	51	45	2	EFO_0003761, EFO_0008343

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVNMKQKPVWNDLNP	DNAH11	2191	Q96DT5
KLNLTMNVQLVNLWP	CDHR4	321	A6H8M9
KQKQNRPIPQWIRMK	RPL39P5	16	Q59GN2
NIPVLDIKKCQPEMW	RECK	396	O95980
QWEQLNNKNLSMPLL	SERPIND1	41	P05546
VPQMLVNLWGPKKTI	OR2H2	76	O95918
SKIMPKTLNPQWREQ	MCTP1	506	Q6DN14
KTCLFQKWQRMVAPP	LDB1	271	Q86U70
LAVQKLEMWLQNPKL	INTS1	366	Q8N201
NSLNQKPNKKILMWL	KAT2B	501	Q92831
KPNKKILMWLVGLQN	KAT2B	506	Q92831
EPAKPKKGQQLWNRM	LENG8	211	Q96PV6
NCLPLRFWVNMIKNP	PLXNA4	1741	Q9HCM2
EINMKNEALQKLWPQ	LRRC49	641	Q8IUZ0
TEQWPQKLIMQLIPQ	MED25	441	Q71SY5
VKLLNQPNQWPLVKA	JUP	486	P14923
RVNPPTLRMKKLNWQ	INF2	556	Q27J81
PMQKLQDLVNRTPWK	RBBP5	241	Q15291
WPQKLIMQLIPQQLL	PTOV1	136	Q86YD1
KQLQPWQPSRKVDIM	GAL3ST3	351	Q96A11
VAELDNPMQQKWTKP	C2CD2L	311	O14523
MKLQPVPWFIGKIIQ	DNAH3	1681	Q8TD57
WVACQQMPQIPRDNK	CCNDBP1	156	O95273
KPQCWNAMTQKPQLI	C17orf80	481	Q9BSJ5
MPVFNWVALKPNQIN	FMNL2	626	Q96PY5
QATQMLKLQNLVIPW	IL2RG	141	P31785
VIAIKMKQPCQWQSI	MARCHF11	221	A6NNE9
MSQQKQQSWKPPNVP	LCE6A	1	A0A183
LVQQWPQMQKSAIKD	DDX10	696	Q13206
KTVNQKMPWNIVLLL	SLC13A2	411	Q13183
VPQMLVNLWGPKKTI	OR2H1	76	Q9GZK4
IWNPQPSQMNRIKIR	FAM83G	436	A6ND36
NIPQIQYKNPWVQIM	MRPS25	51	P82663
QQLLPPNQVKIWFMD	TDRD15	311	B5MCY1
KQKQNRPIPQWIQMK	RPL39L	16	Q96EH5
KQKQNRPIPQWIRMK	RPL39	16	P62891
NNMSEIQKQPKWGPV	SECISBP2	231	Q96T21
QAQFLWKKMQVPTNL	STRC	1166	Q7RTU9
KKNINLQPMWQLLPV	XIRP2	2026	A4UGR9
PKQWVAVCMQGQKVL	ZNF174	131	Q15697
IKSMPLKQQLQWDPS	THAP9	281	Q9H5L6
WELKTQQPLMLKNQL	TBCE	431	Q15813
WLQAQMLNPQPEKTF	XPOT	86	O43592
KALNWKPQLSMPQKS	ZNF484	811	Q5JVG2
QQAQFLWKKMQVPTN	STRCP1	1166	A6NGW2
WPMQILIKCPNQIVR	USP34	2356	Q70CQ2
IWQKTLTVLNPMKPV	YIPF7	126	Q8N8F6
PAQFQQAWMQNKVPI	WDR33	501	Q9C0J8
VKWKPSPLMTNNNVV	MTNR1A	331	P48039