Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A SCN8A	1.99e-07	14	77	4	GO:0031402
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN3A SCN8A	2.86e-06	26	77	4	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A SCN8A	2.86e-06	26	77	4	GO:0031420
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN3A SCN8A	4.81e-05	52	77	4	GO:0005272
GeneOntologyMolecularFunction	channel activity	SLC12A6 SCN1A SCN2A SCN3A SCN8A GSDMA GRIN2A KCNIP2 RYR1	1.85e-04	525	77	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC12A6 SCN1A SCN2A SCN3A SCN8A GSDMA GRIN2A KCNIP2 RYR1	1.87e-04	526	77	9	GO:0022803
GeneOntologyMolecularFunction	beta-N-acetylhexosaminidase activity	HEXA HEXB	2.18e-04	6	77	2	GO:0004563
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN1A SCN2A SCN3A SCN8A GRIN2A KCNIP2 RYR1	3.56e-04	343	77	7	GO:0005261
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC12A6 SCN1A SCN2A SCN3A SCN8A GRIN2A KCNIP2 RYR1	4.20e-04	465	77	8	GO:0046873
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	SCN1A SCN2A GRIN2A KCNIP2 RYR1	6.92e-04	182	77	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	SCN1A SCN2A GRIN2A KCNIP2 RYR1	7.27e-04	184	77	5	GO:0022832
GeneOntologyBiologicalProcess	regulation of termination of DNA-templated transcription	ZMPSTE24 SCAF8 WNK1	9.54e-07	6	76	3	GO:0031554
GeneOntologyBiologicalProcess	behavior	HEXA HEXB ZMPSTE24 NPS SCN1A SCN2A SCN3A TLR2 SCN8A CLSTN2 GPR171 GRIN2A MYO15A PMCH	4.03e-06	891	76	14	GO:0007610
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN3A SCN8A	9.17e-06	36	76	4	GO:0086010
GeneOntologyBiologicalProcess	action potential	NPS SCN1A SCN2A SCN3A SCN8A GRIN2A KCNIP2	9.31e-06	201	76	7	GO:0001508
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN1A SCN2A SCN3A SCN8A KCNIP2	1.74e-05	87	76	5	GO:0086001
GeneOntologyBiologicalProcess	sensory perception of mechanical stimulus	HEXA HEXB LRIG2 SCN1A SCN8A GRIN2A MYO15A	2.77e-05	238	76	7	GO:0050954
GeneOntologyBiologicalProcess	adult walking behavior	HEXA ZMPSTE24 SCN1A SCN8A	3.45e-05	50	76	4	GO:0007628
GeneOntologyBiologicalProcess	transmission of nerve impulse	SCN1A SCN2A SCN3A SCN8A PRX	5.87e-05	112	76	5	GO:0019226
GeneOntologyBiologicalProcess	walking behavior	HEXA ZMPSTE24 SCN1A SCN8A	7.10e-05	60	76	4	GO:0090659
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SCAF8 WNK1	8.00e-05	4	76	2	GO:1904594
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN3A SCN8A	8.07e-05	62	76	4	GO:0086002
GeneOntologyBiologicalProcess	locomotory behavior	HEXA HEXB ZMPSTE24 SCN1A SCN8A GRIN2A MYO15A	8.47e-05	284	76	7	GO:0007626
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN3A SCN8A	8.60e-05	63	76	4	GO:0019228
GeneOntologyBiologicalProcess	chloride ion homeostasis	CKB SLC12A6 WNK1	1.04e-04	25	76	3	GO:0055064
GeneOntologyBiologicalProcess	myelination	HEXA HEXB SCN2A TLR2 SCN8A PRX	1.13e-04	206	76	6	GO:0042552
GeneOntologyBiologicalProcess	heart contraction	ZMPSTE24 SCN1A SCN2A SCN3A SCN8A KCNIP2 PMCH	1.14e-04	298	76	7	GO:0060047
GeneOntologyBiologicalProcess	axon ensheathment	HEXA HEXB SCN2A TLR2 SCN8A PRX	1.22e-04	209	76	6	GO:0008366
GeneOntologyBiologicalProcess	ensheathment of neurons	HEXA HEXB SCN2A TLR2 SCN8A PRX	1.22e-04	209	76	6	GO:0007272
GeneOntologyBiologicalProcess	dermatan sulfate catabolic process	HEXA HEXB	1.33e-04	5	76	2	GO:0030209
GeneOntologyBiologicalProcess	heart process	ZMPSTE24 SCN1A SCN2A SCN3A SCN8A KCNIP2 PMCH	1.43e-04	309	76	7	GO:0003015
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	CKB SLC12A6 WNK1	1.47e-04	28	76	3	GO:0055081
GeneOntologyBiologicalProcess	DNA-templated transcription termination	ZMPSTE24 SCAF8 WNK1	2.65e-04	34	76	3	GO:0006353
GeneOntologyBiologicalProcess	ganglioside catabolic process	HEXA HEXB	2.78e-04	7	76	2	GO:0006689
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN1A SCN2A SCN3A SCN8A	3.88e-04	93	76	4	GO:0086003
GeneOntologyBiologicalProcess	RNA export from nucleus	NUP188 THOC2 WNK1 PCID2	4.37e-04	96	76	4	GO:0006405
GeneOntologyBiologicalProcess	dermatan sulfate metabolic process	HEXA HEXB	5.92e-04	10	76	2	GO:0030205
GeneOntologyBiologicalProcess	sensory perception of pain	SCN1A GPR171 GRIN2A PRX	6.14e-04	105	76	4	GO:0019233
GeneOntologyBiologicalProcess	muscle contraction	CALD1 SCN1A SCN2A SCN3A SCN8A KCNIP2 RYR1	6.78e-04	400	76	7	GO:0006936
GeneOntologyBiologicalProcess	nerve development	LRIG2 SCN1A SCN2A SCN8A	7.07e-04	109	76	4	GO:0021675
GeneOntologyBiologicalProcess	regulation of mRNA export from nucleus	THOC2 WNK1	7.21e-04	11	76	2	GO:0010793
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN3A SCN8A	3.90e-07	17	77	4	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN3A SCN8A	3.77e-06	29	77	4	GO:0034706
GeneOntologyCellularComponent	beta-N-acetylhexosaminidase complex	HEXA HEXB	1.34e-05	2	77	2	GO:1905379
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	5.24e-05	20	77	3	GO:0033268
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	1.64e-04	29	77	3	GO:0043194
GeneOntologyCellularComponent	cation channel complex	SCN1A SCN2A SCN3A SCN8A KCNIP2 RYR1	2.31e-04	235	77	6	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	SCN1A SCN2A SCN3A SCN8A GRIN2A KCNIP2 RYR1	4.85e-04	378	77	7	GO:0034702
HumanPheno	Focal hemiclonic seizure	SCN1A SCN2A SCN8A GRIN2A	1.14e-05	25	30	4	HP:0006813
HumanPheno	Simple febrile seizure	SCN1A SCN2A SCN3A SCN8A	1.56e-05	27	30	4	HP:0011171
HumanPheno	Focal automatism seizure	SCN1A SCN2A SCN8A	3.91e-05	12	30	3	HP:0032898
HumanPheno	Generalized clonic seizure	SCN1A SCN2A SCN8A GRIN2A	4.01e-05	34	30	4	HP:0011169
HumanPheno	Hyperkinetic movements	SCN1A SCN2A GRIN2A THOC2	7.71e-05	40	30	4	HP:0002487
HumanPheno	Clonic seizure	SCN1A SCN2A SCN3A SCN8A GRIN2A	9.37e-05	81	30	5	HP:0020221
HumanPheno	Focal clonic seizure	SCN1A SCN2A SCN8A GRIN2A	9.37e-05	42	30	4	HP:0002266
HumanPheno	Complex febrile seizure	SCN1A SCN2A SCN8A	9.81e-05	16	30	3	HP:0011172
HumanPheno	Non-convulsive status epilepticus without coma	SCN1A SCN2A GRIN2A	1.96e-04	20	30	3	HP:0032671
HumanPheno	Psychomotor deterioration	HEXA SCN2A SCN8A	1.96e-04	20	30	3	HP:0002361
HumanPheno	Bilateral tonic-clonic seizure with focal onset	SCN1A SCN2A SCN8A GRIN2A	2.18e-04	52	30	4	HP:0007334
HumanPheno	Tibial torsion	SCN1A SCN2A FIBP	3.02e-04	23	30	3	HP:0100694
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	3.32e-04	5	30	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	3.32e-04	5	30	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	3.32e-04	5	30	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	3.32e-04	5	30	2	HP:0032823
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	3.32e-04	5	30	2	HP:0032906
HumanPheno	Intellectual disability, borderline	SCN3A SCN8A GRIN2A	3.89e-04	25	30	3	HP:0006889
HumanPheno	Generalized tonic seizure	SCN1A SCN2A SCN8A GRIN2A	4.86e-04	64	30	4	HP:0010818
HumanPheno	Status epilepticus without prominent motor symptoms	SCN1A SCN2A GRIN2A	4.90e-04	27	30	3	HP:0031475
HumanPheno	Exercise-induced rhabdomyolysis	ACADVL RYR1	4.96e-04	6	30	2	HP:0009045
HumanPheno	Normal interictal EEG	SCN2A SCN8A	4.96e-04	6	30	2	HP:0002372
HumanPheno	Abnormal myelination	HEXB SLC12A6 SCN1A SCN2A SCN3A INTS11 SCN8A GRIN2A NUP188 WNK1 PRX	5.03e-04	622	30	11	HP:0012447
HumanPheno	Decreased sensory nerve conduction velocity	SLC12A6 WNK1 PRX	5.47e-04	28	30	3	HP:0003448
HumanPheno	Focal aware seizure	SCN1A SCN2A GRIN2A	5.47e-04	28	30	3	HP:0002349
HumanPheno	Intrinsic hand muscle atrophy	SLC12A6 PRX RYR1	5.47e-04	28	30	3	HP:0008954
HumanPheno	Epileptic encephalopathy	SCN1A SCN2A SCN3A SCN8A GRIN2A	5.71e-04	119	30	5	HP:0200134
HumanPheno	Abnormal sensory nerve conduction velocity	SLC12A6 WNK1 PRX	6.08e-04	29	30	3	HP:0040132
HumanPheno	Premature skin wrinkling	SLC25A24 LZTR1 ZMPSTE24 SCN1A	6.13e-04	68	30	4	HP:0100678
MousePheno	abnormal posture	HEXB LRIG2 SLC12A6 ZMPSTE24 PSIP1 SCN1A SCN8A RYR1	1.12e-05	243	62	8	MP:0001504
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	4.19e-09	6	78	4	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	4.19e-09	6	78	4	IPR024583
Domain	Na_channel_asu	SCN1A SCN2A SCN3A SCN8A	5.80e-08	10	78	4	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	5.80e-08	10	78	4	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	5.80e-08	10	78	4	PF06512
Domain	Beta_hexosaminidase_sua/sub	HEXA HEXB	1.72e-05	2	78	2	IPR025705
Domain	Glycohydro_20b2	HEXA HEXB	1.72e-05	2	78	2	PF14845
Domain	HEX_eukaryotic_N	HEXA HEXB	1.72e-05	2	78	2	IPR029019
Domain	-	HEXA HEXB	1.72e-05	2	78	2	3.30.379.10
Domain	Chitobiase/Hex_dom_2-like	HEXA HEXB	1.72e-05	2	78	2	IPR029018
Domain	IQ	SCN1A SCN2A SCN3A SCN8A MYO15A	2.23e-05	81	78	5	SM00015
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN8A MYO15A	3.72e-05	90	78	5	IPR000048
Domain	IQ	SCN1A SCN2A SCN3A SCN8A MYO15A	4.35e-05	93	78	5	PS50096
Domain	Glyco_hydro_20	HEXA HEXB	5.15e-05	3	78	2	PF00728
Domain	Glyco_hydro_20_cat	HEXA HEXB	5.15e-05	3	78	2	IPR015883
Domain	Channel_four-helix_dom	SCN1A SCN2A SCN3A SCN8A	9.40e-05	57	78	4	IPR027359
Domain	-	SCN1A SCN2A SCN3A SCN8A	9.40e-05	57	78	4	1.20.120.350
Domain	Ion_trans_dom	SCN1A SCN2A SCN3A SCN8A RYR1	1.15e-04	114	78	5	IPR005821
Domain	Ion_trans	SCN1A SCN2A SCN3A SCN8A RYR1	1.15e-04	114	78	5	PF00520
Domain	EF-hand-dom_pair	SLC25A24 SCN1A SCN3A SCN8A KCNIP2 CALML6 RYR1	1.96e-04	287	78	7	IPR011992
Domain	IQ	SCN1A SCN3A SCN8A MYO15A	2.21e-04	71	78	4	PF00612
Domain	EF-hand_8	KCNIP2 CALML6 RYR1	3.82e-04	34	78	3	PF13833
Domain	Sel1	DELE1 SEL1L2	4.74e-04	8	78	2	PF08238
Domain	SEL1	DELE1 SEL1L2	4.74e-04	8	78	2	SM00671
Domain	Sel1-like	DELE1 SEL1L2	6.08e-04	9	78	2	IPR006597
Domain	EF-hand_7	SLC25A24 KCNIP2 CALML6	5.41e-03	85	78	3	PF13499
Domain	LRRCT	LRIG2 TLR2	7.87e-03	32	78	2	PF01463
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN3A SCN8A	6.84e-06	28	63	4	M45519
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN3A SCN8A	1.04e-05	31	63	4	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN2A SCN3A SCN8A	1.19e-05	32	63	4	M27455
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN1A SCN2A SCN3A SCN8A KCNIP2 RYR1	2.42e-05	130	63	6	M27454
Pathway	REACTOME_MUSCLE_CONTRACTION	CALD1 SCN1A SCN2A SCN3A SCN8A KCNIP2 RYR1	3.24e-05	203	63	7	M5485
Pathway	WP_RETT_SYNDROME	SCN1A SCN2A SCN8A GRIN2A	6.08e-05	48	63	4	M39759
Pathway	KEGG_MEDICUS_REFERENCE_KERATAN_SULFATE_DEGRADATION	HEXA HEXB	1.95e-04	5	63	2	M47609
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A SCN8A	2.34e-11	4	78	4	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A SCN8A	2.34e-11	4	78	4	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A SCN8A	2.34e-11	4	78	4	29578003
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN8A	3.50e-10	6	78	4	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN3A SCN8A	2.92e-09	9	78	4	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A SCN8A	2.92e-09	9	78	4	15746173
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	1.09e-08	3	78	3	12610651
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	1.09e-08	3	78	3	23859570
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	1.09e-08	3	78	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	1.09e-08	3	78	3	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	1.09e-08	3	78	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	1.09e-08	3	78	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	1.09e-08	3	78	3	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	1.09e-08	3	78	3	14973256
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A SCN8A	1.14e-08	12	78	4	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN8A	1.65e-08	13	78	4	15123669
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	4.33e-08	4	78	3	21156207
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	4.33e-08	4	78	3	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	4.33e-08	4	78	3	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A	1.08e-07	5	78	3	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A	1.08e-07	5	78	3	8812438
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A SCN8A	1.08e-07	5	78	3	17724025
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	1.08e-07	5	78	3	24337656
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	3.77e-07	7	78	3	25818041
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	2.35e-06	12	78	3	8169823
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A SCN3A	4.84e-06	15	78	3	9726281
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	4.97e-06	2	78	2	29649454
Pubmed	Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.	HEXA HEXB	4.97e-06	2	78	2	8123671
Pubmed	Activity of lysosomal exoglycosidases in human gliomas.	HEXA HEXB	4.97e-06	2	78	2	16710745
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	4.97e-06	2	78	2	20346423
Pubmed	Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.	HEXA HEXB	4.97e-06	2	78	2	3013851
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	4.97e-06	2	78	2	37901435
Pubmed	Genetic expression of hexokinase and glucose phosphate isomerase in late-stage mouse preimplantation embryos: transcription activities in glucose/phosphate-containing HTF and glucose/phosphate-free P1 media.	HEXA HEXB	4.97e-06	2	78	2	9237263
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	4.97e-06	2	78	2	26410685
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	4.97e-06	2	78	2	10827969
Pubmed	Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.	HEXA HEXB	4.97e-06	2	78	2	6458607
Pubmed	Different expression of beta-N-acetylhexosaminidase in mouse tissues.	HEXA HEXB	4.97e-06	2	78	2	8147878
Pubmed	Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	4.97e-06	2	78	2	8789434
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	4.97e-06	2	78	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	4.97e-06	2	78	2	35348308
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	4.97e-06	2	78	2	11245985
Pubmed	KLKB1 and CLSTN2 are associated with HDL-mediated cholesterol efflux capacity in a genome-wide association study.	CLSTN2 KLKB1	4.97e-06	2	78	2	36812656
Pubmed	Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.	HEXA HEXB	4.97e-06	2	78	2	2965147
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	4.97e-06	2	78	2	15760941
Pubmed	The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.	FRMPD2 GRIN2A	4.97e-06	2	78	2	31196628
Pubmed	The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis.	HEXA HEXB	4.97e-06	2	78	2	1825792
Pubmed	Identification of domains in human beta-hexosaminidase that determine substrate specificity.	HEXA HEXB	4.97e-06	2	78	2	8663217
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	4.97e-06	2	78	2	1317301
Pubmed	Plasma and peripheral leukocyte beta-N-acetylhexosaminidase isoenzymes and disease activity in rheumatoid arthritis.	HEXA HEXB	4.97e-06	2	78	2	12413610
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	4.97e-06	2	78	2	23016767
Pubmed	A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.	HEXA HEXB	4.97e-06	2	78	2	9694901
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	4.97e-06	2	78	2	27153334
Pubmed	GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.	HEXA HEXB	4.97e-06	2	78	2	22789865
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	4.97e-06	2	78	2	33096315
Pubmed	Pediatric reference data on activity of urinary N-acetyl-β-D-hexosaminidase and its isoenzymes.	HEXA HEXB	4.97e-06	2	78	2	28846871
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	4.97e-06	2	78	2	24990319
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	4.97e-06	2	78	2	31439038
Pubmed	HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.	CKB SLC12A6	4.97e-06	2	78	2	18566107
Pubmed	I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.	HEXA HEXB	4.97e-06	2	78	2	10591618
Pubmed	Biochemical consequences of mutations causing the GM2 gangliosidoses.	HEXA HEXB	4.97e-06	2	78	2	10571007
Pubmed	Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.	HEXA HEXB	4.97e-06	2	78	2	7550345
Pubmed	Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.	HEXA HEXB	4.97e-06	2	78	2	9417048
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	4.97e-06	2	78	2	17805013
Pubmed	Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology.	HEXA HEXB	4.97e-06	2	78	2	19166507
Pubmed	A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.	DPYSL3 PTGR1	4.97e-06	2	78	2	20804502
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	4.97e-06	2	78	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	4.97e-06	2	78	2	33411788
Pubmed	Physiological substrates for human lysosomal beta -hexosaminidase S.	HEXA HEXB	4.97e-06	2	78	2	11707436
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	4.97e-06	2	78	2	31943325
Pubmed	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.	HEXA HEXB	4.97e-06	2	78	2	8634145
Pubmed	Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.	HEXA HEXB	4.97e-06	2	78	2	8672428
Pubmed	[Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].	HEXA HEXB	4.97e-06	2	78	2	23370522
Pubmed	Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay-Sachs Disease and Sandhoff Disease Mouse Models.	HEXA HEXB	4.97e-06	2	78	2	34201771
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	4.97e-06	2	78	2	15249644
Pubmed	Novel bicistronic lentiviral vectors correct β-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis.	HEXA HEXB	4.97e-06	2	78	2	31682993
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	4.97e-06	2	78	2	27690330
Pubmed	Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.	HEXA HEXB	4.97e-06	2	78	2	8673609
Pubmed	Three novel mutations in Iranian patients with Tay-Sachs disease.	HEXA HEXB	4.97e-06	2	78	2	24518553
Pubmed	Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.	HEXA HEXB	4.97e-06	2	78	2	15953731
Pubmed	Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells.	HEXA HEXB	4.97e-06	2	78	2	21637923
Pubmed	Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.	HEXA HEXB	4.97e-06	2	78	2	2971395
Pubmed	Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology.	HEXA HEXB	4.97e-06	2	78	2	9184660
Pubmed	Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	4.97e-06	2	78	2	9302266
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	4.97e-06	2	78	2	21377452
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	4.97e-06	2	78	2	18601978
Pubmed	Knock-down of HEXA and HEXB genes correlate with the absence of the immunostimulatory function of HSC-derived dendritic cells.	HEXA HEXB	4.97e-06	2	78	2	21997228
Pubmed	Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.	HEXA HEXB	4.97e-06	2	78	2	8896570
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	4.97e-06	2	78	2	23965409
Pubmed	Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.	HEXA HEXB	4.97e-06	2	78	2	16698036
Pubmed	Accumulated α-synuclein affects the progression of GM2 gangliosidoses.	HEXA HEXB	4.97e-06	2	78	2	27453479
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	4.97e-06	2	78	2	19465131
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	4.97e-06	2	78	2	37665666
Pubmed	Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.	HEXA HEXB	4.97e-06	2	78	2	6230359
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	4.97e-06	2	78	2	17881658
Pubmed	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.	HEXA HEXB	4.97e-06	2	78	2	7959736
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	4.97e-06	2	78	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	4.97e-06	2	78	2	23735284
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	LZTR1 RRP1B ACADVL GSDMA NUP188 ATAD2 PCID2	1.00e-05	332	78	7	25693804
Pubmed	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	SLC25A24 RRP1B CCDC81	1.40e-05	21	78	3	25017104
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	1.49e-05	3	78	2	19284629
Interaction	GPR171 interactions	DAZAP1 ACADVL GPR171	5.33e-07	5	77	3	int:GPR171
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	2.96e-06	8	77	3	int:SCN4B
Cytoband	2q24.3	SCN1A SCN2A	3.37e-04	16	78	2	2q24.3
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN3A SCN8A	1.11e-08	9	57	4	1203
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RRP1B CEP192 WNK1 HYDIN RYR1	2.61e-04	181	57	5	694
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 APOB ATAD2 RBM47 KLKB1 SEC14L4	7.39e-07	179	78	6	bf012825e88626e59cd1deebf67c2cd269ce4829
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB GPR171 RBM47 RYR1 SNX13	1.19e-05	169	78	5	46f0f0de9a0894c454f93032e7a7a800f47c8276
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SCN3A GPX3 KLKB1 HYDIN	1.19e-05	169	78	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	DPYSL3 BMX CALD1 SCN3A PMCH	1.30e-05	172	78	5	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Pvalb_(Non-anterior_nuclei)\|Thalamus / BrainAtlas - Mouse McCarroll V32	GSDMA HS6ST3 SEC14L4 ALPK2	1.67e-05	87	78	4	fd0df79b02f96463a6bad90dcd019c59c8e3eb0e
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	FRMPD2 CCDC81 CLSTN2 SEC14L4 HYDIN	1.70e-05	182	78	5	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SCN2A APOB MYO15A HYDIN	1.80e-05	184	78	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SCN2A APOB MYO15A HYDIN	1.80e-05	184	78	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A SCN2A APOB MYO15A HYDIN	1.80e-05	184	78	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A SCN8A GSDMA CLSTN2 KCNIP2	1.84e-05	185	78	5	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CKB ZMPSTE24 SCN2A WNK1 HS6ST3	2.10e-05	190	78	5	223587b5df037794a2cee234babf87d12bf48ac8
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_reg\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSIP1 DUSP16 AAK1 GPR171 PMCH	2.26e-05	193	78	5	2a06bb3d6bbe544a26dc42d94a10f60acfd3600b
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_reg-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSIP1 DUSP16 AAK1 GPR171 PMCH	2.26e-05	193	78	5	b4f8afd871fdf9418b92ff419c8ba9739b6093ca
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN2A SCN3A CLSTN2 GRIN2A HS6ST3	2.37e-05	195	78	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A GRIN2A	2.55e-05	198	78	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A GRIN2A	2.55e-05	198	78	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A GRIN2A	2.55e-05	198	78	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SCN2A SCN3A SCN8A AAK1 GRIN2A	2.68e-05	200	78	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKB ACADVL PTGR1 GPX3 RBM47	2.68e-05	200	78	5	4bbb35d43d238fdd173fe2557cb31d2b56f767b5
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MROH2A GSDMA ALPK2	4.38e-05	39	78	3	8b5d15f979a92799a9e77f1b501d3c4fa4e8695a
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MROH2A GSDMA ALPK2	4.38e-05	39	78	3	a24eb4c26344c5c97bbf39a1adc56ee34013dc4f
ToppCell	T_cells-Treg_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SLC12A6 SEL1L2 SEC14L4 PMCH	1.01e-04	138	78	4	35880e23ef317862891b54ac6a2265ca03b1d12a
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A2 MROH2A PIWIL4 MYO15A	1.10e-04	141	78	4	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A2 MROH2A PIWIL4 MYO15A	1.10e-04	141	78	4	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A2 MROH2A PIWIL4 MYO15A	1.13e-04	142	78	4	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SCN2A SCN3A APOB HS6ST3	1.26e-04	146	78	4	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LZTR1 SCN1A FAM83G C1orf141	1.40e-04	150	78	4	6f7087a051a2f05c5611ff65a945c01736d5ec2b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SCN1A SCN2A INTS11 WNK1	1.43e-04	151	78	4	f41c6558a5874b6464c157027fdf202257c60e5b
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	DUSP16 FAM83G GSDMA PMCH	1.51e-04	153	78	4	cda759ab83a271974651fe4faa21ed4f7ecbb3ae
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZMPSTE24 SCN2A SEL1L2 WNK1	1.51e-04	153	78	4	79c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Fos_(iSPN,_IEG+)\|Striatum / BrainAtlas - Mouse McCarroll V32	NPS SLC25A2 GPR171	1.52e-04	59	78	3	a72de8cda377c87fa9a6fbda72735d850650f9f4
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Fos_(iSPN,_IEG+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	NPS SLC25A2 GPR171	1.52e-04	59	78	3	3ab024fa7a927177da0dc764cee46dabdd008040
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCN1A SCN2A SCN3A KCNIP2	1.59e-04	155	78	4	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Serpinb1a_(Serpinb1a)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NPS PIWIL4 APOB	1.60e-04	60	78	3	48adafeec1810bce5f118fa63d4a8ee7ab9ca0f7
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Serpinb1a_(Serpinb1a)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NPS PIWIL4 APOB	1.60e-04	60	78	3	a83afb89dbfc2e1cdfce57320d89c980bd8fb820
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 APOB KLKB1 RYR1	1.67e-04	157	78	4	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 APOB KLKB1 RYR1	1.67e-04	157	78	4	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 APOB KLKB1 RYR1	1.67e-04	157	78	4	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB DUSP16 GPX3 RYR1	1.83e-04	161	78	4	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB SLC12A6 BMX ALPK2	1.88e-04	162	78	4	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	droplet-Kidney-nan-21m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB HEXA HEXB TLR2	1.97e-04	164	78	4	d4cdcd61e8c28b3fb912cef8837cc1a49678a729
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A MROH2A SCN3A WNK1	1.97e-04	164	78	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A MROH2A SCN3A WNK1	1.97e-04	164	78	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A MROH2A SCN3A WNK1	1.97e-04	164	78	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A MROH2A SCN3A WNK1	1.97e-04	164	78	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	droplet-Kidney-nan-21m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB HEXA HEXB TLR2	2.01e-04	165	78	4	9852a4cb680af39c92c7d2d5e5fa8dc04e6602aa
ToppCell	droplet-Kidney-nan-21m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB HEXA HEXB TLR2	2.01e-04	165	78	4	c629ed33ff14834c32cc1a91116fb079f7aaa94d
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CALD1 SCN3A AAK1 CLSTN2	2.06e-04	166	78	4	26f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DUSP16 FAM83G CLSTN2 ATAD2	2.16e-04	168	78	4	187b98664843a304406f086ea696adbf32283d07
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC12A6 NIM1K GPR171 ATAD2	2.21e-04	169	78	4	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CKB GPR171 RBM47 RYR1	2.21e-04	169	78	4	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(Neuron.Slc17a6.Nts)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC25A2 GPR171 ALPK2	2.22e-04	67	78	3	bc06a697f47b60c43e238f8c6803a1b061f22550
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(Neuron.Slc17a6.Nts)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC25A2 GPR171 ALPK2	2.22e-04	67	78	3	50acd69659f6d827868dc48bfb00af8634a8b4c7
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cbln2_(Neuron.Slc17a6.Rora.Cbln2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MROH2A GSDMA SEC14L4	2.22e-04	67	78	3	5202166895fd109ad0d7584fc35c74814a59ce2b
ToppCell	facs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM83G MYO15A SEC14L4 HYDIN	2.26e-04	170	78	4	82ccba6ec53f6ca0d19949a1277434c565af2983
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM83G MYO15A SEC14L4 HYDIN	2.26e-04	170	78	4	ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CCDC81 WNK1 KLKB1	2.36e-04	172	78	4	bc1b889ac5e07b8324ae5837eca911f9c865e959
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CCDC81 WNK1 KLKB1	2.36e-04	172	78	4	ba70b6110b70afb1870e8dcaf58c507b8c7d918e
ToppCell	Ionocyte-iono-2\|World / Class top	HEXA HEXB SCN3A GSDMA	2.41e-04	173	78	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RRP1B SCN1A SCN8A HS6ST3	2.63e-04	177	78	4	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	facs-Lung-EPCAM-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB GPR171 RBM47 RYR1	2.63e-04	177	78	4	e73e2b6a72630bb56ac2af1cdeedc8f0f828f390
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN3A GPX3 PCDH8	2.63e-04	177	78	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN3A GPX3 PCDH8	2.63e-04	177	78	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSIP1 AAK1 GPR171 PMCH	2.69e-04	178	78	4	90dedb3cef9b01907b9f8eec64218d6d2072be1f
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSIP1 AAK1 GPR171 PMCH	2.69e-04	178	78	4	d6312286bf6cc5b107ccd7adb583d9667d4e1d21
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENOX1 SCN3A GSDMA CLSTN2	2.69e-04	178	78	4	30ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CALD1 SCN3A GRIN2A HS6ST3	2.75e-04	179	78	4	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CALD1 PSIP1 ATAD2	2.75e-04	179	78	4	ff678e2f33c914e3dd0f338ada25f506c3e3c980
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCN1A SCN2A SCN3A HS6ST3	2.75e-04	179	78	4	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMX ACADVL WDR20 ATAD2	2.81e-04	180	78	4	baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMX ACADVL WDR20 ATAD2	2.81e-04	180	78	4	2d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CKB ENOX1 CCDC81 ALPK2	2.81e-04	180	78	4	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMX ACADVL WDR20 ATAD2	2.81e-04	180	78	4	0f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell	HSPCs-Mono_prog.\|HSPCs / Lineage and Cell class	HEXA TLR2 GPX3 RBM47	2.87e-04	181	78	4	a188f0d22426d8723ba394d94d20431afa6722a7
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	ENOX1 FRMPD2 CCDC81 HYDIN	2.93e-04	182	78	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	DPYSL3 SCN2A SCN3A SCN8A	2.93e-04	182	78	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPYSL3 CALD1 GRIN2A PRX	2.93e-04	182	78	4	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ENOX1 TLL2 DUSP16 TLR2	2.93e-04	182	78	4	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC25A24 RP2 RYR1 PMCH	2.99e-04	183	78	4	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNIP2 HS6ST3 PCDH8 HYDIN	3.05e-04	184	78	4	30fddbc9696476d4d7f08e53f84ea994a4ed873a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNIP2 HS6ST3 PCDH8 HYDIN	3.05e-04	184	78	4	96926efa220f03d0787322c9519bb9e8f64f74d0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CALD1 SCN3A GRIN2A HS6ST3	3.11e-04	185	78	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CALD1 SCN3A GRIN2A HS6ST3	3.11e-04	185	78	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A GPX3 PIWIL4 PCDH8	3.18e-04	186	78	4	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	facs-Lung-EPCAM-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A GPR171 RBM47 SEC14L4	3.18e-04	186	78	4	7c4eb769574f9f32753cea1cc38c711dabba88b9
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SCN2A SCN3A SCN8A PMCH	3.18e-04	186	78	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB PTGR1 GPX3 ATAD2	3.24e-04	187	78	4	a7f1656a33b8f88acf655ba609e3858354fff565
ToppCell	(2)_5-FU-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)\|(2)_5-FU / Stress and Cell class	DPYSL3 CALD1 PTGR1 GPX3	3.24e-04	187	78	4	6bbf0f7fe203274dae8d582652f35cd3187c0065
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPYSL3 CALD1 SCN3A CLSTN2	3.31e-04	188	78	4	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SCN2A SCN3A CLSTN2 PCDH8	3.31e-04	188	78	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PSIP1 AAK1 GPR171 PMCH	3.31e-04	188	78	4	e5c480b9a030536578f1cc91fb61738f752525b3
ToppCell	(1)_T_CD4_reg\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DUSP16 AAK1 WNK1 PMCH	3.38e-04	189	78	4	28f28672fd260bb2a8d64152737a7242347c3174
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CALD1 GPX3 SCN8A CLSTN2	3.38e-04	189	78	4	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DPYSL3 CALD1 GPX3 CLSTN2	3.38e-04	189	78	4	d531399749409d614adca13d181830c6e3287508
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKB ENOX1 SCN2A WNK1	3.38e-04	189	78	4	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CALD1 GPX3 CLSTN2 ALPK2	3.38e-04	189	78	4	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CALD1 SCN8A CLSTN2	3.38e-04	189	78	4	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CALD1 GPX3 SCN8A CLSTN2	3.44e-04	190	78	4	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	normal_Lung-Fibroblasts-Undetermined\|normal_Lung / Location, Cell class and cell subclass	DPYSL3 CALD1 GPX3 SEL1L2	3.44e-04	190	78	4	30d4658bcc6796f0cdf54cc029f4bb904b13ef66
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SCN2A SCN8A AAK1 GRIN2A	3.44e-04	190	78	4	416de85d8841dac883faa6f5339b2fb461a09e82
Drug	hydroxyachillin	HEXA HEXB RP2	3.85e-07	5	78	3	CID000099114
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN8A	7.68e-07	6	78	3	ctd:C475726
Drug	leucodin	HEXA HEXB RP2	1.34e-06	7	78	3	CID000167683
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN8A	2.14e-06	8	78	3	ctd:C489827
Drug	AC1L1ICP	SLC12A6 APOB GRIN2A	4.56e-06	10	78	3	CID000004520
Drug	nicotinoylprocaine	CKB HEXA HEXB	8.32e-06	12	78	3	CID000159667
Drug	Tetrodotoxin	SCN2A SCN3A SCN8A GRIN2A	1.06e-05	40	78	4	ctd:D013779
Drug	PNP-GlcNAc-6-SO4	HEXA HEXB	1.16e-05	2	78	2	CID000133365
Drug	Zonisamide	SCN1A SCN2A SCN3A	2.54e-05	17	78	3	DB00909
Drug	PNP-(GlcNAc)5	HEXA HEXB	3.47e-05	3	78	2	CID003081071
Drug	farnesane	HEXA HEXB	3.47e-05	3	78	2	CID000019773
Drug	Primidone [125-33-7]; Up 200; 18.4uM; PC3; HT_HG-U133A	ENOX1 CALD1 TLL2 AAK1 PMCH SNX13	5.95e-05	197	78	6	6723_UP
Drug	methionine methyl ester	HEXA HEXB	6.92e-05	4	78	2	CID000064684
Drug	ADSN deriv.	HEXA HEXB	6.92e-05	4	78	2	CID006451109
Drug	inositol nicotinate	HEXA APOB	6.92e-05	4	78	2	CID000003720
Drug	NP-009007	HEXA HEXB	6.92e-05	4	78	2	CID011390848
Drug	rabdosiin	HEXA HEXB	6.92e-05	4	78	2	CID000471121
Drug	diglycolamine	HEXA HEXB	6.92e-05	4	78	2	CID000013578
Drug	AC1NT0TY	HEXA HEXB	6.92e-05	4	78	2	CID005321775
Drug	triphenylacetic acid	HEXA HEXB	6.92e-05	4	78	2	CID000068992
Drug	CHBZ	HEXA HEXB	6.92e-05	4	78	2	CID000054550
Drug	APETx2 protein, Anthopleura elegantissima	SCN2A SCN8A	6.92e-05	4	78	2	ctd:C501880
Drug	oxyphyllol A	HEXA HEXB	6.92e-05	4	78	2	CID000637451
Drug	malathion monoacid	HEXA HEXB	6.92e-05	4	78	2	CID003032927
Drug	T0702	HEXA HEXB RYR1	8.43e-05	25	78	3	CID000005908
Drug	l 3000	ZDHHC2 HEXA HEXB	1.07e-04	27	78	3	CID000102475
Drug	gemfibrozil	CKB HEXA HEXB ZMPSTE24 WDR20 APOB	1.15e-04	222	78	6	CID000003463
Drug	myricanol	HEXA HEXB	1.15e-04	5	78	2	CID000161779
Drug	myricanone	HEXA HEXB	1.15e-04	5	78	2	CID000161748
Drug	AC1Q6SGD	ZDHHC2 HEXA	1.15e-04	5	78	2	CID000016775
Drug	4-ethylguaiacol	HEXA RYR1	1.15e-04	5	78	2	CID000062465
Drug	AC1L9A0M	PRPF3 TLR2 CLSTN2 RP2	1.22e-04	74	78	4	CID000440822
Drug	cyfluthrin	SCN2A SCN3A HYDIN	1.33e-04	29	78	3	ctd:C052570
Drug	fenpropathrin	SCN2A SCN3A	1.72e-04	6	78	2	ctd:C044267
Drug	tetra-N-acetylchitotetraose	HEXA HEXB	1.72e-04	6	78	2	CID003081988
Drug	cyclic oxamide	HEXA HEXB	1.72e-04	6	78	2	CID000468476
Drug	X1207	HEXA HEXB	1.72e-04	6	78	2	CID000084718
Drug	dihexyl ether	HEXA WDR20	1.72e-04	6	78	2	CID000008198
Drug	psoralidin	HEXA HEXB	1.72e-04	6	78	2	CID005281806
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	8.89e-09	10	77	4	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	8.89e-09	10	77	4	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	2.09e-08	12	77	4	DOID:0060170 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SLC12A6 SCN1A SCN2A SCN3A SCN8A GRIN2A	4.44e-06	163	77	6	DOID:1826 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	2.01e-05	3	77	2	cv:C5575231
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A	2.54e-05	22	77	3	DOID:2030 (implicated_via_orthology)
Disease	Bipolar Disorder	SLC12A6 DAZAP1 TLL2 SCN2A TLR2 SCN8A GRIN2A PMCH	3.49e-05	477	77	8	C0005586
Disease	Epilepsy, Cryptogenic	SCN1A SCN2A SCN8A GRIN2A	6.42e-05	82	77	4	C0086237
Disease	Awakening Epilepsy	SCN1A SCN2A SCN8A GRIN2A	6.42e-05	82	77	4	C0751111
Disease	Aura	SCN1A SCN2A SCN8A GRIN2A	6.42e-05	82	77	4	C0236018
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	1.00e-04	6	77	2	C0220669
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	1.40e-04	7	77	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	1.40e-04	7	77	2	C0751057
Disease	Epilepsy	SCN1A SCN2A SCN8A GRIN2A	1.94e-04	109	77	4	C0014544
Disease	Febrile Convulsions	SCN1A SCN2A	2.39e-04	9	77	2	C0009952
Disease	Myoclonic Epilepsy	HEXB SCN1A	2.39e-04	9	77	2	C0014550
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	2.39e-04	9	77	2	C3502809
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	5.15e-04	13	77	2	C0751122
Disease	MMR-related febrile seizures	SCN1A SCN2A	6.90e-04	15	77	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	7.88e-04	16	77	2	C0393706
Disease	type 1 diabetes mellitus (is_marker_for)	TLR2 GPX3 APOB	8.95e-04	72	77	3	DOID:9744 (is_marker_for)
Disease	syndrome (implicated_via_orthology)	ZDHHC2 SCAF8	1.00e-03	18	77	2	DOID:225 (implicated_via_orthology)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	1.00e-03	18	77	2	HP_0002373
Disease	coagulation factor measurement	ENOX1 PCID2	1.24e-03	20	77	2	EFO_0004634
Disease	response to xenobiotic stimulus	ANKRD31 ENOX1 ZNF175 SCN1A	1.33e-03	182	77	4	GO_0009410
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ANKRD31 APOB SNX13	1.50e-03	86	77	3	EFO_0008595, EFO_0020945
Disease	sleep duration, low density lipoprotein cholesterol measurement	ANKRD31 APOB SNX13	1.76e-03	91	77	3	EFO_0004611, EFO_0005271
Disease	Neurodevelopmental Disorders	SCN1A SCN2A SCN8A	1.87e-03	93	77	3	C1535926
Disease	cholesterol to total lipids in small LDL percentage	ANKRD31 APOB	2.26e-03	27	77	2	EFO_0022241
Disease	cholesterol to total lipids in medium LDL percentage	ANKRD31 APOB	2.26e-03	27	77	2	EFO_0022238
Disease	Colorectal Carcinoma	ZDHHC2 FRMPD2 TLR2 APOB CLSTN2 GRIN2A WNK1	2.38e-03	702	77	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAQTGKFERMFSAGK	C1orf141	341	Q5JVX7
MKKFFDSRREQGGSG	AAK1	1	Q2M2I8
KGFKGNCSMTFIDQF	ALPK2	2101	Q86TB3
RQKGKEGAFMVRNSS	BMX	311	P51813
KGMTTVDDFFQGTKA	DPYSL3	81	Q14195
AGFVSQSRGQEKSKM	GPX3	16	P22352
TGNFGFKNMLDTRVE	GSDMA	76	Q96QA5
QGDKRVAFFMRKGAD	ATAD2	486	Q6PL18
SSEMIFKFDGRQGAK	CLSTN2	351	Q9H4D0
SMAKDVDRDNKGFFN	CALML6	76	Q8TD86
IMKDKTTNQSRGFGF	DAZAP1	41	Q96EP5
SAADKMKNRGFAFVE	RBM47	186	A0AV96
FRNGVGTGMKKTSFQ	NPS	71	P0C0P6
VDFGKNVMKEFLGEN	IPPK	56	Q9H8X2
SMFEKTKFGQGTSRE	ANKRD31	1816	Q8N7Z5
CRDKMFVFSGQSGAK	LZTR1	236	Q8N653
AVDKKGEANFFTSQM	INTS11	111	Q5TA45
QKGGNMKEVFTRFCT	CKB	241	P12277
AFFEQQGMDKPARSK	MYO15A	456	Q9UKN7
KVSGDTSFRLMKQFN	PCDH8	56	O95206
ENVGKGKEAFSMTFG	FAM214A	416	Q32MH5
SNVGCMEFKKEFGRN	GPR171	161	O14626
SFFQKMDRNKDGVVT	KCNIP2	231	Q9NS61
DKSNQLFFGKVGRQM	MIGA2	366	Q7L4E1
GFSTVSKKGEMLNTF	NIM1K	216	Q8IY84
KNMAFFGLTEFQRKT	HS6ST3	346	Q8IZP7
VGRKAMFDSDFKQAE	PCID2	216	Q5JVF3
SEMLFFGNAIEGKSN	APOB	2841	P04114
TNMGKVGFEFKVLTD	HYDIN	1411	Q4G0P3
RKNFEAMFKGILQSG	CASP5	11	P51878
RSISMKQNVEFTFKG	CCDC81	136	Q6ZN84
ANGLGFSFVQMEKES	FRMPD2	1086	Q68DX3
FDFGGNIIMFSTDKQ	EIF3I	101	Q13347
KQFKRRSCQMEFGES	DUSP16	621	Q9BY84
GKTEDTFFMSNKPQR	CEP192	686	Q8TEP8
YKGVDMRGVNFNVSK	KLKB1	116	P03952
EKHGFNQQTLGFFMK	ZMPSTE24	151	O75844
KIQDFMRQKGFGTDF	HEXB	366	P07686
ASRGQKAKSMEGFQD	SLC12A6	1056	Q9UHW9
GVSFNKKLMDRFDFG	SCAF8	256	Q9UPN6
FGVFLKTKMGEQQSA	SEC14L4	316	Q9UDX3
DFQKAMDSQKQFSGP	RYR1	4091	P21817
MFKQEFTGVGATLEK	ENOX1	616	Q8TC92
DMVFNTFRLGKGFQK	PMCH	36	P20382
IAFNFLGTENMKSGD	DELE1	246	Q14154
GTAKDRSFGEMKFKQ	PRPF3	636	O43395
QGFSFNKMFTEKATE	PRIMPOL	226	Q96LW4
EFSNTVIGQMKKFGR	PTGR1	221	Q14914
FFSQMETNKEAVRVG	MROH2A	391	A6NES4
KGALAQKFMFVDGDR	FAM83G	251	A6ND36
RGKLGVFSEMEANFK	FIBP	266	O43427
QDFMRKKGFGEDFKQ	HEXA	336	P06865
KGKGDFARKMDTFVN	SNX13	691	Q9Y5W8
FGLNRNMTAEFKKTD	RRP1B	686	Q14684
KNFTDEGDQLFKMGI	SEL1L2	101	Q5TEA6
GSTFMERGVKNKQDF	PIWIL4	66	Q7Z3Z4
GGKEMNEIKTQFTTR	WDR20	6	Q8TBZ3
KKFGGQDIFMTEEQK	SCN3A	1476	Q9NY46
GFCQQFVRKVAGMDK	SLC25A2	86	Q9BXI2
KKFGGQDIFMTEEQK	SCN1A	1491	P35498
KSFAVGMFKGQLTTD	ACADVL	71	P49748
FMDRKKGFTEVKSQN	CALD1	481	Q05682
KGFTEVKSQNGEFMT	CALD1	486	Q05682
QVTNSMFGASRKKFV	CNOT2	16	Q9NZN8
NKFKNMFLVGEGDSV	PSIP1	421	O75475
GKSFMKEFQSDGSKQ	THOC2	456	Q8NI27
ATKAEQAEGMEFGFK	PRX	786	Q9BXM0
KKFGGQDIFMTEEQK	SCN2A	1481	Q99250
NEIFNGTKMFVSESK	RP2	316	O75695
MKFVSDGSINKAGFA	TLL2	556	Q9Y6L7
TKMFKEQGFGSRQTN	NUP188	236	Q5SRE5
KKKFGGQDIFMTEEQ	SCN8A	1471	Q9UQD0
DKNGFSLGFSKNMRQ	ZDHHC2	256	Q9UIJ5
SLGFSKNMRQVFGDE	ZDHHC2	261	Q9UIJ5
NRKMVTFKFDLDGDN	WNK1	1141	Q9H4A3
VGNMDTFTKIQRKDF	TLR2	156	O60603
GSKSDKMNIFGGFRQ	SLC25A24	226	Q6NUK1
SFQKDMVGEFTRDGS	ZNF175	116	Q9Y473
TFNDMKNVPEAFKGT	WBP2	31	Q969T9
MQRNGISKLKDGAFF	LRIG2	246	O94898
NRSFQGKESIFGDNM	GRIN2A	946	Q12879