Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN-succinyltransferase activity

ALAS1 ALAS2

4.11e-062412GO:0016749
GeneOntologyMolecularFunction5-aminolevulinate synthase activity

ALAS1 ALAS2

4.11e-062412GO:0003870
GeneOntologyMolecularFunctionsuccinyltransferase activity

ALAS1 ALAS2

1.23e-053412GO:0016748
GeneOntologyMolecularFunctionpyridoxal phosphate binding

ALAS1 ALAS2 KYAT1

2.07e-0456413GO:0030170
GeneOntologyMolecularFunctionvitamin B6 binding

ALAS1 ALAS2 KYAT1

2.18e-0457413GO:0070279
GeneOntologyMolecularFunctionN-acyltransferase activity

ALAS1 ALAS2 CREBBP

1.20e-03102413GO:0016410
GeneOntologyCellularComponentnuclear matrix

SFPQ PBRM1 NONO ANP32A

1.61e-04140414GO:0016363
GeneOntologyCellularComponentparaspeckles

SFPQ NONO

1.67e-0410412GO:0042382
GeneOntologyCellularComponentnuclear periphery

SFPQ PBRM1 NONO ANP32A

3.46e-04171414GO:0034399
DomainPreseq_ALAS

ALAS1 ALAS2

4.47e-062402PF09029
Domain4pyrrol_synth_NH2levulA_synth

ALAS1 ALAS2

4.47e-062402IPR010961
Domain5aminolev_synth_preseq

ALAS1 ALAS2

4.47e-062402IPR015118
DomainAminotransferase_I/II

ALAS1 ALAS2 KYAT1

6.06e-0617403IPR004839
DomainAminotran_1_2

ALAS1 ALAS2 KYAT1

6.06e-0617403PF00155
DomainAmyloid_glyco_E2_domain

APLP2 APP

1.34e-053402IPR024329
DomainA4_EXTRA

APLP2 APP

1.34e-053402PS00319
DomainAmyloid_glyco_heparin-bd

APLP2 APP

1.34e-053402IPR015849
DomainAPP_Cu_bd

APLP2 APP

1.34e-053402PF12924
DomainAPP_E2

APLP2 APP

1.34e-053402PF12925
DomainAPP_amyloid

APLP2 APP

1.34e-053402PF10515
DomainA4_INTRA

APLP2 APP

1.34e-053402PS00320
DomainAmyloid_glyco

APLP2 APP

1.34e-053402IPR008155
DomainAmyloid_glyco_extra

APLP2 APP

1.34e-053402IPR008154
DomainNOPS

SFPQ NONO

1.34e-053402PF08075
Domain-

APLP2 APP

1.34e-0534023.90.570.10
DomainNOPS

SFPQ NONO

1.34e-053402IPR012975
Domain-

APLP2 APP

1.34e-0534023.30.1490.140
DomainAPP_amyloid_C

APLP2 APP

1.34e-053402IPR019543
DomainAmyloid_glyco_extracell_CS

APLP2 APP

1.34e-053402IPR019744
DomainAmyloid_glyco_intracell_CS

APLP2 APP

1.34e-053402IPR019745
DomainAmyloid_glyco_Cu-bd

APLP2 APP

1.34e-053402IPR011178
DomainAPP_N

APLP2 APP

1.34e-053402PF02177
DomainA4_EXTRA

APLP2 APP

1.34e-053402SM00006
Domain-

ALAS1 ALAS2 KYAT1

5.68e-05354033.90.1150.10
DomainPyrdxlP-dep_Trfase_major_sub2

ALAS1 ALAS2 KYAT1

6.19e-0536403IPR015422
DomainAA_TRANSFER_CLASS_2

ALAS1 ALAS2

6.67e-056402PS00599
DomainAminotrans_II_pyridoxalP_BS

ALAS1 ALAS2

6.67e-056402IPR001917
Domain-

ALAS1 ALAS2 KYAT1

7.88e-05394033.40.640.10
DomainPyrdxlP-dep_Trfase

ALAS1 ALAS2 KYAT1

9.17e-0541403IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

ALAS1 ALAS2 KYAT1

9.17e-0541403IPR015421
Domain-

APLP2 APP

6.70e-04184024.10.410.10
DomainPrtase_inh_Kunz-CS

APLP2 APP

6.70e-0418402IPR020901
DomainKU

APLP2 APP

6.70e-0418402SM00131
DomainBPTI_KUNITZ_2

APLP2 APP

7.47e-0419402PS50279
DomainKunitz_BPTI

APLP2 APP

7.47e-0419402PF00014
DomainBPTI_KUNITZ_1

APLP2 APP

7.47e-0419402PS00280
DomainEPHD

KMT2C JADE3

1.01e-0322402PS51805
DomainKunitz_BPTI

APLP2 APP

1.10e-0323402IPR002223
DomainBromodomain_CS

PBRM1 CREBBP

1.41e-0326402IPR018359
Domain-

KMT2C RIMS1 JADE3 RNF111 RING1

2.58e-034494053.30.40.10
DomainZnf_RING/FYVE/PHD

KMT2C RIMS1 JADE3 RNF111 RING1

2.84e-03459405IPR013083
DomainBROMODOMAIN_1

PBRM1 CREBBP

2.84e-0337402PS00633
DomainBromodomain

PBRM1 CREBBP

2.99e-0338402PF00439
DomainBROMODOMAIN_2

PBRM1 CREBBP

3.48e-0341402PS50014
DomainBROMO

PBRM1 CREBBP

3.65e-0342402SM00297
DomainBromodomain

PBRM1 CREBBP

3.65e-0342402IPR001487
Domain-

PBRM1 CREBBP

3.65e-03424021.20.920.10
DomainZnf_FYVE_PHD

KMT2C RIMS1 JADE3

3.81e-03147403IPR011011
PathwayWP_HEME_BIOSYNTHESIS

ALAS1 ALAS2

1.89e-049332M39470
PathwayKEGG_MEDICUS_REFERENCE_HEME_BIOSYNTHESIS

ALAS1 ALAS2

1.89e-049332M47606
PathwayWP_HEMESYNTHESIS_DEFECTS_AND_PORPHYRIAS

ALAS1 ALAS2

1.89e-049332M45555
PathwayWP_HEME_BIOSYNTHESIS

ALAS1 ALAS2

1.89e-049332MM15895
PathwayBIOCARTA_SET_PATHWAY

CREBBP ANP32A

2.36e-0410332M3075
PathwayBIOCARTA_AHSP_PATHWAY

ALAS1 ALAS2

4.08e-0413332M19553
PathwayREACTOME_HEME_BIOSYNTHESIS

ALAS1 ALAS2

4.08e-0413332MM14720
PathwayREACTOME_INTERLEUKIN_1_FAMILY_SIGNALING

PTPN23 APP TAB3 MAP3K3

4.17e-04152334M899
PathwayBIOCARTA_SET_PATHWAY

CREBBP ANP32A

4.75e-0414332MM1403
PathwayREACTOME_HEME_BIOSYNTHESIS

ALAS1 ALAS2

4.75e-0414332M27059
PathwayREACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE

ALAS1 AKAP9 CREBBP CNTRL HAUS5

5.87e-04297335M27050
PathwayREACTOME_AURKA_ACTIVATION_BY_TPX2

AKAP9 CNTRL HAUS5

6.24e-0472333M27749
PathwayREACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES

AKAP9 CNTRL HAUS5

8.81e-0481333M748
Pubmed

A human MAP kinase interactome.

LAMA3 PTPN23 KMT2C APLP2 SFPQ CREBBP MAP3K3 CNTRL RNF111

4.45e-0948641920936779
Pubmed

The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation.

SFPQ NONO

1.36e-06241225765647
Pubmed

Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.

APLP2 APP

1.36e-06241219710207
Pubmed

Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism.

SFPQ NONO

1.36e-06241235886974
Pubmed

Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites.

ALAS1 ALAS2

1.36e-0624122780318
Pubmed

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.

APLP2 APP

1.36e-0624127758106
Pubmed

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.

APLP2 APP

1.36e-06241218393365
Pubmed

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.

APLP2 APP

1.36e-06241221459473
Pubmed

Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.

APLP2 APP

1.36e-06241221435241
Pubmed

Interaction of human and mouse Abeta peptides.

APLP2 APP

1.36e-06241215584916
Pubmed

Amyloid precursor protein trafficking, processing, and function.

APLP2 APP

1.36e-06241218650430
Pubmed

SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining.

SFPQ NONO

1.36e-06241227924002
Pubmed

Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro.

APLP2 APP

1.36e-06241216584729
Pubmed

Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.

SFPQ NONO

1.36e-06241215590677
Pubmed

Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome.

ALAS1 ALAS2

1.36e-0624122347585
Pubmed

PSF and p54(nrb)/NonO--multi-functional nuclear proteins.

SFPQ NONO

1.36e-06241212417296
Pubmed

Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes.

ALAS1 ALAS2

1.36e-0624122263504
Pubmed

Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.

SFPQ NONO

1.36e-0624128439294
Pubmed

AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.

APLP2 APP

1.36e-06241219403832
Pubmed

CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5.

LAMA3 CREBBP

1.36e-06241216219677
Pubmed

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

APLP2 APP

1.36e-06241221266574
Pubmed

Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.

APLP2 APP

1.36e-06241218535156
Pubmed

The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.

SFPQ NONO

1.36e-06241217965020
Pubmed

Differential distribution of Alzheimer's amyloid precursor protein family variants in human sperm.

APLP2 APP

1.36e-06241217405931
Pubmed

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.

APLP2 APP

1.36e-06241224448592
Pubmed

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.

APLP2 APP

1.36e-06241226658856
Pubmed

Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator.

ALAS1 CREBBP

1.36e-06241212433930
Pubmed

Hippocampal network oscillations in APP/APLP2-deficient mice.

APLP2 APP

1.36e-06241223585881
Pubmed

Generation of conditional null alleles for APP and APLP2.

APLP2 APP

1.36e-06241220140888
Pubmed

Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.

SFPQ NONO

1.36e-06241225605962
Pubmed

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue.

APLP2 APP

1.36e-06241225098278
Pubmed

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.

APLP2 APP

1.36e-0624129461064
Pubmed

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.

APLP2 APP

1.36e-06241230506868
Pubmed

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.

APLP2 APP

1.36e-06241210526140
Pubmed

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

APLP2 APP

1.36e-06241221522131
Pubmed

Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.

APLP2 APP

1.36e-06241215919150
Pubmed

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.

APLP2 APP

1.36e-06241215447675
Pubmed

PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices.

SFPQ NONO

1.36e-06241210858305
Pubmed

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.

APLP2 APP

1.36e-06241226551565
Pubmed

Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments.

APLP2 APP

1.36e-06241222490781
Pubmed

PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression.

SFPQ NONO

1.36e-06241212944487
Pubmed

Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.

APLP2 APP

1.36e-06241232219307
Pubmed

The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase.

ALAS1 ALAS2

1.36e-06241211566198
Pubmed

Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase.

ALAS1 ALAS2

1.36e-06241219917609
Pubmed

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.

APLP2 APP

1.36e-06241215689559
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HIP1R MED12L KMT2C SMG5 JADE3 HAUS5 EFR3A

2.60e-0652941714621295
Pubmed

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

APLP2 APP

4.06e-06341211050115
Pubmed

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

APLP2 APP

4.06e-06341225432317
Pubmed

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

APLP2 APP

4.06e-06341220693289
Pubmed

Differential role of APP and APLPs for neuromuscular synaptic morphology and function.

APLP2 APP

4.06e-06341224998676
Pubmed

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

APLP2 APP

4.06e-06341229018038
Pubmed

P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.

SFPQ NONO

4.06e-06341216148043
Pubmed

Regulation of gene expression by the APP family in the adult cerebral cortex.

APLP2 APP

4.06e-06341234997052
Pubmed

hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.

SFPQ NONO

4.06e-06341219874820
Pubmed

MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2.

APLP2 APP

4.06e-06341222510281
Pubmed

Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.

SFPQ NONO

4.06e-06341218655028
Pubmed

The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.

APLP2 APP

4.06e-06341221445342
Pubmed

PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription.

SFPQ NONO

4.06e-06341216641145
Pubmed

Amyloid precursor proteins are constituents of the presynaptic active zone.

APLP2 APP

4.06e-06341223815291
Pubmed

Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.

SFPQ NONO

4.06e-06341222213094
Pubmed

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

SFPQ NONO

4.06e-06341215790595
Pubmed

Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition.

ALAS1 ALAS2

4.06e-06341216234850
Pubmed

Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference.

APLP2 APP

4.06e-06341216889988
Pubmed

APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival.

APLP2 APP

4.06e-06341232891188
Pubmed

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.

APLP2 APP

4.06e-06341219126676
Pubmed

RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling.

SFPQ NONO

4.06e-06341230445466
Pubmed

APLP2 regulates neuronal stem cell differentiation during cortical development.

APLP2 APP

4.06e-06341223345401
Pubmed

Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein.

APLP2 APP

4.06e-06341215561424
Pubmed

Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.

SFPQ NONO

4.06e-06341225326457
Pubmed

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

APLP2 APP

4.06e-06341229661886
Pubmed

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.

SFPQ NONO

4.06e-06341217639083
Pubmed

Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.

APLP2 APP

4.06e-06341224898256
Pubmed

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response.

SFPQ NONO

4.06e-06341220421735
Pubmed

APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons.

APLP2 APP

4.06e-06341234172567
Pubmed

Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.

SFPQ NONO

4.06e-0634129393982
Pubmed

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.

APLP2 APP

4.06e-06341215677459
Pubmed

The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.

SFPQ NONO

4.06e-06341211525732
Pubmed

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

APLP2 APP

4.06e-06341216193067
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SLC12A6 MCM5 ALAS2 SFPQ RIMS1 NONO LYST CNTRL CCDC158 RING1

5.03e-061442411035575683
Pubmed

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

SFPQ PBRM1 NONO

5.44e-062941319279220
Pubmed

Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.

MCM5 SFPQ AKAP9

5.44e-062941318239623
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

KMT2C MCM5 SFPQ PBRM1 NONO

6.02e-0622041535785414
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

HIP1R KMT2C MCM5 APLP2 PBRM1 APP NONO PLPP6 DDX10 EFR3A

7.00e-061497411031527615
Pubmed

Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.

APLP2 SFPQ NONO

7.36e-063241331815296
Pubmed

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.

APLP2 APP

8.12e-06441214983046
Pubmed

First identification of ITM2B interactome in the human retina.

APLP2 APP

8.12e-06441234446781
Pubmed

APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo.

APLP2 APP

8.12e-06441228495363
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C CREBBP

8.12e-06441228398509
Pubmed

Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.

SFPQ NONO

8.12e-06441227259250
Pubmed

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.

APLP2 APP

8.12e-06441215208260
Pubmed

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.

APLP2 APP

8.12e-0644128855266
Pubmed

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.

APLP2 APP

8.12e-0644128894693
Pubmed

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.

APLP2 APP

8.12e-06441217556541
Pubmed

Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.

APLP2 APP

8.12e-06441216314516
Pubmed

Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.

SFPQ NONO

8.12e-06441232764370
Pubmed

Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.

APLP2 APP

8.12e-06441234008862
Pubmed

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.

APLP2 APP

8.12e-06441220855613
Pubmed

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.

APLP2 APP

8.12e-0644129461550
Pubmed

The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.

SFPQ NONO

8.12e-0644129756848
Pubmed

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.

APLP2 APP

8.12e-06441210460257
InteractionH3-4 interactions

KMT2C MCM5 SFPQ PBRM1 JADE3 NONO CREBBP ANP32A DDX10 RING1

1.24e-084484010int:H3-4
InteractionERG interactions

KMT2C SFPQ APP NONO CREBBP RNF111 RING1

2.53e-07223407int:ERG
InteractionSOX7 interactions

KMT2C PBRM1 APP CREBBP

2.08e-0582404int:SOX7
InteractionTMOD4 interactions

ALAS1 APP HAUS5

2.55e-0529403int:TMOD4
InteractionTSG101 interactions

HIP1R PTPN23 SFPQ AKAP9 NONO RNF111

2.74e-05303406int:TSG101
InteractionPPARG interactions

KMT2C SFPQ PBRM1 APP CREBBP ANP32A

2.95e-05307406int:PPARG
InteractionLHX3 interactions

KMT2C PBRM1 CREBBP ANP32A RING1

3.13e-05185405int:LHX3
InteractionFOXI1 interactions

KMT2C APP CREBBP RING1

3.28e-0592404int:FOXI1
InteractionTTC23 interactions

MED12L ALAS1 SFPQ APP NONO

5.47e-05208405int:TTC23
InteractionPAX6 interactions

KMT2C PBRM1 APP CREBBP RNF111 RING1

7.85e-05366406int:PAX6
InteractionALAS2 interactions

ALAS1 ALAS2

8.02e-057402int:ALAS2
InteractionETS1 interactions

APLP2 PBRM1 APP CREBBP

9.56e-05121404int:ETS1
InteractionPITX3 interactions

SFPQ NONO

1.07e-048402int:PITX3
InteractionFHL1 interactions

MCM5 APP CREBBP RING1

1.22e-04129404int:FHL1
InteractionORC6 interactions

MCM5 SFPQ APP

1.25e-0449403int:ORC6
InteractionACYP1 interactions

APP NONO

1.37e-049402int:ACYP1
InteractionH2BC3 interactions

KMT2C MCM5 PBRM1 APP CREBBP RING1

1.38e-04406406int:H2BC3
InteractionZNF706 interactions

APP NONO

1.71e-0410402int:ZNF706
CytobandEnsembl 112 genes in cytogenetic band chr15q23

CELF6 ANP32A

1.71e-0368412chr15q23
CytobandEnsembl 112 genes in cytogenetic band chr3p21

PTPN23 ALAS1 PBRM1

2.84e-03316413chr3p21
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SFPQ AKAP9 NONO

2.98e-03181293694
GeneFamilyRNA binding motif containing

CELF6 SFPQ NONO

4.70e-03213293725
GeneFamilyPHD finger proteins

KMT2C JADE3

9.12e-039029288
CoexpressionHARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_28DY_POSITIVE

MED12L SLC12A6 TMEM170B MCM5 APLP2 ALAS1 SFPQ APP PPM1J JADE3 LYST MAP3K3

2.86e-0712504112M41099
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C APLP2 RIMS1 LYST MAP3K3

1.03e-06198415d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA3 WNT10A APLP2 APP NONO

1.03e-0619841522559b161e67b49fe8028bfaf861e069063599f5
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA3 APLP2 PBRM1 APP NONO

1.06e-061994158d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell367C-Lymphocytic-ILC-ILC-2|367C / Donor, Lineage, Cell class and subclass (all cells)

HIP1R KYAT1 CNTRL HAUS5

1.91e-051734140451450605521fecb27a958628870d268adfb023
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFPQ AKAP9 LYST CNTRL

2.14e-0517841401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

MED12L RIMS1 APP PPM1J

2.49e-051854143091870a5bf8ecb963e560b47c8502bae367416c
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L WNT10A APP PPM1J

2.54e-051864140096a61b1841784c913752b4f3639200446cc02c
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L WNT10A APP PPM1J

2.54e-051864149e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L WNT10A APP PPM1J

2.54e-051864146345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

HIP1R ALAS2 SFPQ JADE3

2.82e-051914141ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

KLHL11 PBRM1 AKAP9 EFR3A

2.94e-05193414abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellmild-pDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MED12L WNT10A APP PPM1J

3.18e-0519741415230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP2 PBRM1 APP NONO

3.24e-051984142f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCellBronchial_Biopsy|World / Tissue, Lineage and Cell class of Lung Cells from 10X

LAMA3 WNT10A AKAP9 APP

3.24e-05198414f5b7013045b61fc56894f80092f799770dde1c8f
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP2 PBRM1 APP NONO

3.24e-05198414f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TMEM170B APLP2 APP LYST

3.37e-052004149e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell(54)_pDC|World / shred on Cell_type and subtype

MED12L TMEM170B APP PPM1J

3.58e-05203414b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma-2|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PBRM1 JADE3 LYST

1.70e-0411741394f511dbf639b164c4b096195db312ecee3ee176
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

MCM5 SFPQ NONO

2.65e-041364133e13dc0634f3b05e9f9e6c3193f843f62e603b78
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4|Hippocampus / BrainAtlas - Mouse McCarroll V32

MCM5 SFPQ NONO

2.65e-041364130185486c39700dd2f72d79be6d283494dd8379c9
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM5 NONO KYAT1

3.74e-041534135ac4b97d35c1029a5fc625239f92e35136c4d832
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

APP PPM1J JADE3

3.96e-0415641319472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRS2 KYAT1 DDX10

3.96e-041564137ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELF6 RIMS1 CNTRL

4.03e-04157413f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellControl-B_naive-12|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MRS2 KYAT1 DDX10

4.03e-041574134803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCellControl-B_naive-12|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MRS2 KYAT1 DDX10

4.11e-0415841341318f864770370ce77ed3fa4a84f76c0c22c482
ToppCellsevere_COVID-19-pDC|World / disease group, cell group and cell class (v2)

MED12L WNT10A PPM1J

4.18e-04159413e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

MED12L WNT10A PPM1J

4.18e-04159413ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 LYST CREBBP

4.42e-0416241393bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 RIMS1 LYST

4.42e-04162413373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALAS2 LYST TAB3

4.58e-04164413f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L WNT10A PPM1J

4.66e-04165413e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCellInt-URO-Myeloid-tDC|Int-URO / Disease, Lineage and Cell Type

MED12L APP PPM1J

4.66e-041654139803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

TMEM170B APP PPM1J

4.91e-04168413dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALAS1 PPM1J HAUS5

4.91e-04168413260c768468dff51888f7a68e5424bb174dbaa759
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALAS1 PPM1J HAUS5

4.91e-0416841318d7719a76620d5e5698f9ffd08b4ad4cb7c13f8
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL11 ALAS2 TAB3

5.08e-0417041337c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MCM5 PBRM1 RING1

5.08e-041704130f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL11 ALAS2 TAB3

5.08e-04170413b180ec9a1b79025a180c8559c27c31272410dea8
ToppCell3'_v3-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue

MED12L ALAS1 TAB3

5.08e-041704134dedf482cd4521b3f87d2b5ae80f7a3ea8686a15
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MCM5 KYAT1 CNTRL

5.08e-0417041332917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCellICU-SEP-Myeloid-pDC|ICU-SEP / Disease, Lineage and Cell Type

MED12L APP PPM1J

5.17e-0417141372c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L MCM5 HAUS5

5.17e-04171413bf475a69db04d4a886e442704955c6a96ff0de46
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 WNT10A RIMS1

5.26e-04172413bd73fd3520064d430a153cfdd5c2858b6c184c59
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

WNT10A APP DDX10

5.26e-041724130657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

MED12L APP PPM1J

5.26e-04172413dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 WNT10A RIMS1

5.26e-0417241347ee78ed3ba6516dad8f12dbf70bca5ed1c60aff
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HIP1R APLP2 LYST

5.35e-04173413694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

HIP1R LYST CNTRL

5.35e-04173413d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 WNT10A RIMS1

5.44e-04174413583955b4db442ba0583e2312af242f050547f9d6
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MED12L WNT10A APP

5.44e-04174413ab654e87c7eab7f33adc61be7a86da5c4d88008d
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

MED12L TMEM170B APP

5.44e-04174413ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MED12L WNT10A APP

5.44e-041744132453419842fd22d066631615403393bfe4449bb8
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MED12L WNT10A APP

5.44e-04174413d9bccff5258c4277bdd1edbd87e17c327ec125e8
ToppCellmild_COVID-19-pDC|mild_COVID-19 / disease group, cell group and cell class (v2)

MED12L APP PPM1J

5.53e-04175413b87f279a7519710146c49d6acccb0adedc195965
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L WNT10A APP

5.53e-041754136d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

WNT10A APP PPM1J

5.53e-0417541397fe431f224b592b3076632d101e19136c138dcc
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L WNT10A APP

5.53e-041754136839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L WNT10A APP

5.53e-041754139d6135e183179968555670abec39dff9da2c3219
ToppCellwk_20-22-Hematologic_Lymphocytic-B-Pro-B/Pre-B_transition|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MRS2 KYAT1 RNF111

5.53e-04175413f86d2d212f8314b2410d5d84ef092b0b38607ea4
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

WNT10A APP PPM1J

5.62e-0417641359a9c262c252b7d220a025837922d98e9d6b0a24
ToppCellControl-Myeloid-pDC|Control / Disease group,lineage and cell class （2021.01.30）

MED12L WNT10A APP

5.62e-04176413baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCellBAL-Control-Lymphocyte-B|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L JADE3 HAUS5

5.62e-041764137c1ecec45b5fe5e73cbce0fadca726ffd10c0316
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WNT10A APP PPM1J

5.72e-041774139e65b39fd797b6ce204b6480415810d1923acee5
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|myeloid / Lineage, cell class and subclass

WNT10A APP PPM1J

5.81e-04178413f75591988bbbeba073b66329a3437cb9b02f7648
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

MED12L APP PPM1J

5.81e-04178413072b346c6bbd63f00efaceda486400a669b3ec48
ToppCellCOPD-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

MED12L WNT10A APP

5.91e-0417941329b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCellnormal_Lung-B_lymphocytes|normal_Lung / Location, Cell class and cell subclass

WNT10A ALAS2 PPM1J

5.91e-041794135b89193486100b6754c1c5eca3105ea955805eae
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____fenestrated_capillary_endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL11 ZBTB48 HAUS5

6.00e-0418041379c5725f02e038d0187f4a1e1591f2492538aa57
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5|Hippocampus / BrainAtlas - Mouse McCarroll V32

MCM5 SFPQ NONO

6.00e-0418041344988c34861df359a68376500c42a64fbcc4b431
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

MED12L APP PPM1J

6.20e-0418241397e0eee10905f2cf2bebb09e474629fc224f4397
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA3 RIMS1 LYST

6.20e-04182413a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-pDC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WNT10A APP PPM1J

6.20e-0418241302c0824373a0ecebc922d4ca848ace9d570722c4
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ALAS1 TAB3 RNF111

6.30e-04183413807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MED12L APP PPM1J

6.30e-04183413df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5|Striatum / BrainAtlas - Mouse McCarroll V32

MCM5 SFPQ NONO

6.30e-04183413f20b0d71f857ac35868fd80531050ad8b6091716
ToppCellnormal_Lung-B_lymphocytes-GrB-secreting_B_cells|normal_Lung / Location, Cell class and cell subclass

WNT10A APP PPM1J

6.30e-04183413c930b957d16f9b0904b6c424acd914532e5cc137
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MED12L APP PPM1J

6.30e-041834133b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellLeuk-UTI-Other-RBC|Leuk-UTI / Disease, Lineage and Cell Type

ALAS2 APP PPM1J

6.50e-041854135b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

MED12L APP PPM1J

6.50e-041854137fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellLeuk-UTI-Other|Leuk-UTI / Disease, Lineage and Cell Type

ALAS2 APP PPM1J

6.50e-04185413895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCellICU-NoSEP-Myeloid-pDC|ICU-NoSEP / Disease, Lineage and Cell Type

WNT10A APP PPM1J

6.50e-041854137564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

WNT10A APP PPM1J

6.60e-04186413916f2aeea4989ba7a29e071e348a51010f010223
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|Dendritic_cell / Lineage, cell class and subclass

WNT10A APP PPM1J

6.60e-04186413858134580a09ed8a5eb6d6413d8ca9265904dfc1
ToppCellcontrol-Myeloid-pDC|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

WNT10A APP PPM1J

6.60e-04186413fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCellcontrol-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

WNT10A APP PPM1J

6.60e-04186413fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCellhealthy_donor-Lymphocytic-Dendritic-pDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

WNT10A APP PPM1J

6.60e-0418641345f66619e45d590c7365a51782d4ac46b7d31fde
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

PBRM1 JADE3 CREBBP

6.60e-0418641303db813598b67b1e08f759758a1c2023396921fa
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HIP1R JADE3 MAP3K3

6.60e-04186413055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

HIP1R LAMA3 ZMAT1

6.71e-04187413db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM5 LYST CNTRL

6.71e-0418741314c239af77116d28d511dea754b6150d20488080
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

MED12L APP PPM1J

6.71e-04187413aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCelldroplet-Marrow-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM5 ALAS1 APP

6.81e-041884131526e271411e381eae7a342003002276f83f47a3
ToppCellmyeloid-pDC|myeloid / Lineage and Cell class

WNT10A APP PPM1J

6.81e-04188413a2dc4bbeca2bdc00c51825dd65a699c54c72f241
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L SFPQ ANP32A

6.92e-041894136dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L SFPQ ANP32A

6.92e-041894133ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCellInt-URO-Myeloid-pDC|Int-URO / Disease, Lineage and Cell Type

WNT10A APP PPM1J

6.92e-0418941337aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L SFPQ ANP32A

6.92e-04189413875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCellfacs-Brain_Myeloid-Striatum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L SFPQ ANP32A

6.92e-0418941397ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFPQ PBRM1 AKAP9

7.02e-04190413d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
Drug2-amino-3-ketoadipate

ALAS1 ALAS2

3.16e-062412CID000440714
Drugpregnanedione

ALAS1 ALAS2

3.16e-062412CID000135006
DrugN-benzyloxycarbonyl-valyl-leucyl-leucinal

APLP2 APP

3.16e-062412ctd:C495708
Drugphenserine

APLP2 APP IL21

5.15e-0619413CID000192706
DrugN-methylprotoporphyrin

ALAS1 ALAS2 APP

7.05e-0621413CID000119311
Drugallylisopropylacetamide

ALAS1 ALAS2 PBRM1

1.92e-0529413CID000009297
DrugIsoxicam [34552-84-6]; Up 200; 12uM; HL60; HT_HG-U133A

SFPQ AKAP9 APP JADE3 HAUS5

2.81e-051994151862_UP
DrugMercuric Chloride

LAMA3 SLC12A6 KLHL11 APP ZBTB48 MRS2 CREBBP KYAT1 TAB3 MAP3K3

2.88e-0511554110ctd:D008627
Drug2,3,5-trichlorophenyl methyl sulfone

ALAS1 ALAS2

3.15e-055412CID000128553
Drugthioacetamide-S-oxide

ALAS1 ALAS2

4.72e-056412CID000100800
DrugAC1L3BQY

ALAS1 ALAS2

4.72e-056412CID000137957
DrugZectran

ALAS1 ALAS2

4.72e-056412CID000009414
Drug3-methylcholanthrene

APLP2 ALAS1 ALAS2 PBRM1 APP

5.73e-05231415CID000001674
Drugheptacarboxylic porphyrin

ALAS1 ALAS2

6.61e-057412CID000168414
Drugharderoporphyrin

ALAS1 ALAS2

8.80e-058412CID003081462
Drugtiagabine

ALAS1 KYAT1

8.80e-058412ctd:C059205
DrugAC1L4P5P

ALAS1 ALAS2

8.80e-058412CID000161295
Drugcobalt mesoporphyrin

ALAS1 ALAS2

1.13e-049412CID000161350
DrugPyridoxal Phosphate

ALAS1 ALAS2 KYAT1

1.19e-0453413DB00114
DiseaseAlzheimer's disease 1 (implicated_via_orthology)

APLP2 APP

3.75e-057402DOID:0080348 (implicated_via_orthology)
DiseaseMiT family translocation renal cell carcinoma

SFPQ NONO

3.75e-057402C4518356
DiseaseBipolar Disorder

HIP1R SLC12A6 RIMS1 PBRM1 APP

4.46e-04477405C0005586
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C PBRM1

4.85e-0424402C0345905
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C PBRM1

4.85e-0424402C3805278
DiseaseCholangiocarcinoma

KMT2C PBRM1

5.70e-0426402C0206698
DiseaseSezary Syndrome

KMT2C CREBBP

6.16e-0427402C0036920
Diseaselung small cell carcinoma (is_implicated_in)

LAMA3 PBRM1

6.62e-0428402DOID:5409 (is_implicated_in)
DiseaseCarcinoma, Transitional Cell

KMT2C CREBBP

1.42e-0341402C0007138
Diseaseoral microbiome measurement

KMT2C APLP2

1.49e-0342402EFO_0801229
DiseaseEndogenous depression

APP CREBBP

1.79e-0346402C0011573
DiseasePeripheral Nervous System Diseases

SLC12A6 LYST

2.45e-0354402C4721453

Protein segments in the cluster

PeptideGeneStartEntry
ELLRQAHMRQMERQR

AKAP9

1606

Q99996
AHMRQMERQREDQEQ

AKAP9

1611

Q99996
HERARRLMKELNQMQ

CNTRL

2116

Q7Z7A1
THMARVEAMLNDRRR

APP

456

P05067
QHRLQQAQLMRRRMA

CREBBP

1856

Q92793
MEMGRRIHLELRNRT

ANP32A

1

P39687
RERALRRMQQMAGHL

CELF6

216

Q96J87
RQLVLEVMHNLMDRH

EFR3A

476

Q14156
LPQLVRRMRQQRKHM

PTPN23

1421

Q9H3S7
HLARVEAMLNDRRRM

APLP2

456

Q06481
QEHMFEVLERARRMN

PBRM1

841

Q86U86
EHQVMLMRQDLMRRQ

NONO

306

Q15233
LMRQDLMRRQEELRR

NONO

311

Q15233
RQRALQQRMEMEQHG

KMT2C

3421

Q8NEZ4
ARQMMHEALQLRLNL

MED12L

1511

Q86YW9
AEAQRMMRELRNRNF

LAMA3

1971

Q16787
VLQLMLRRGEIQHRM

MCM5

711

P33992
RRQHQRNVKLMRQML

ALAS1

501

P13196
INLDSHRNVMMRLNL

MRS2

326

Q9HD23
MRRQQHTLRDPMQRL

HAUS5

136

O94927
QRNVKHMRQLLMDRG

ALAS2

451

P22557
EEQQMRMHARVSRAR

RIMS1

371

Q86UR5
MEMGRRIHSELRNRA

ANP32C

1

O43423
DAVRRIEDMMNQARH

HIP1R

796

O75146
RQMQEIHRHALNMRR

KLHL11

686

Q9NVR0
GQDRHMIRMRQLIDI

IL21

31

Q9HBE4
RSVANDELHVMMQRR

LYST

2611

Q99698
SILALHGRQQQMRRM

DDX10

341

Q13206
HLRRELDNRNMEVQR

CCDC158

416

Q5M9N0
LLNMRPDQSNVRRMH

SLC12A6

1071

Q9UHW9
MFMHLRQDLERVRNL

JADE3

471

Q92613
IEEGLRMQAMHRAQR

RING1

141

Q06587
RMQAMHRAQRVRRPI

RING1

146

Q06587
MNDLVALQMNRRHRM

MAP3K3

11

Q99759
QFRMAQEEARRNRLM

SMG5

811

Q9UPR3
QEEARRNRLMRDMAQ

SMG5

816

Q9UPR3
EVNGMEHDLMQRRLR

TAB3

546

Q8N5C8
LMFVMLQRHRQGRVI

TMEM170B

56

Q5T4T1
QAMQRCRDHMIRSLQ

KYAT1

311

Q16773
QLMDEQMARERRGHQ

PPM1J

241

Q5JR12
LRRMEELHNQEMQKR

SFPQ

546

P23246
QETFRRRMELRVHMV

ZBTB48

356

P10074
HPHEVMQRMEVQRRR

RNF111

746

Q6ZNA4
VQRRRMMQHPTRAHE

RNF111

756

Q6ZNA4
LVRRRRPAHNQMDMF

PLPP6

186

Q8IY26
RMRLHNNRVGRQAVM

WNT10A

241

Q9GZT5
RNREMVDVRPRHRML

ZMAT1

426

Q5H9K5