Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	iodide transmembrane transporter activity	SLC5A5 SLC5A6	1.01e-04	5	64	2	GO:0015111
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	MCM8 ATRX N6AMT1 POLA2 ENDOG SLX1A	1.91e-04	262	64	6	GO:0140097
GeneOntologyMolecularFunction	organophosphate:phosphate antiporter activity	SLC37A1 SLC25A25	2.10e-04	7	64	2	GO:0015315
Domain	Na/solute_symporter_CS	SLC5A5 SLC5A6	2.71e-04	8	59	2	IPR018212
Domain	NA_SOLUT_SYMP_1	SLC5A5 SLC5A6	5.30e-04	11	59	2	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A5 SLC5A6	6.34e-04	12	59	2	PS00457
Domain	SSF	SLC5A5 SLC5A6	6.34e-04	12	59	2	PF00474
Domain	Na/solute_symporter	SLC5A5 SLC5A6	6.34e-04	12	59	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A5 SLC5A6	6.34e-04	12	59	2	PS50283
Domain	UBA-like	TNRC6B DHX57 NXF1	1.09e-03	64	59	3	IPR009060
Pubmed	Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).	SREBF1 FBXW7	3.77e-06	2	68	2	16054087
Pubmed	Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus.	SLC5A6 HLCS	3.77e-06	2	68	2	17904341
Pubmed	Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells.	SREBF1 FBXW7	3.77e-06	2	68	2	25893295
Pubmed	FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation.	SREBF1 FBXW7	3.77e-06	2	68	2	33537812
Pubmed	Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.	SREBF1 FBXW7	3.77e-06	2	68	2	22710480
Pubmed	B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance.	CD19 TXNRD2	1.13e-05	3	68	2	17937622
Pubmed	The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth.	SREBF1 FBXW7	1.13e-05	3	68	2	27579997
Pubmed	Fbw7 dimerization determines the specificity and robustness of substrate degradation.	SREBF1 FBXW7	1.13e-05	3	68	2	24298052
Pubmed	Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.	SREBF1 FBXW7	1.13e-05	3	68	2	32301540
Pubmed	Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth.	SREBF1 FBXW7	1.13e-05	3	68	2	26759235
Pubmed	A phosphorylation cascade controls the degradation of active SREBP1.	SREBF1 FBXW7	1.13e-05	3	68	2	19126544
Pubmed	E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells.	CD19 FBXW7	2.25e-05	4	68	2	32005754
Pubmed	BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.	MIB1 FBXW7	2.25e-05	4	68	2	30044990
Pubmed	Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.	SREBF1 FBXW7	3.75e-05	5	68	2	21911492
Pubmed	Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.	SREBF1 FBXW7	3.75e-05	5	68	2	16825193
Pubmed	F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.	CD19 FBXW7	3.75e-05	5	68	2	25555218
Pubmed	An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis.	SREBF1 FBXW7	5.62e-05	6	68	2	23823476
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NOLC1 CELSR3 MIB1 AKNA SCAF11 KCNT1 CAPN10	7.87e-05	529	68	7	14621295
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CACNB1 HAP1 SREBF1 TNRC6B SCAF11 MBD6 NXF1	1.86e-04	608	68	7	16713569
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	CDH22 ENC1 MYO1F RBM5 NXF1	2.36e-04	283	68	5	18854154
Pubmed	Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.	SPN TNFRSF10A	2.90e-04	13	68	2	25980612
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	CELSR3 MIB1 TFRC	3.13e-04	67	68	3	21875946
Pubmed	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.	NOLC1 ATRX	4.44e-04	16	68	2	25416818
Pubmed	Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.	SREBF1 FBXW7	4.44e-04	16	68	2	29472293
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	SLC5A5 SLC5A6 SNTA1	6.08e-04	84	68	3	15123239
Pubmed	Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.	SREBF1 FBXW7	7.00e-04	20	68	2	24912190
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	MAPK15 KLHL25 ENC1 SREBF1 FBXW7	8.18e-04	372	68	5	22939624
Pubmed	Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.	SLC5A5 ATRX	1.10e-03	25	68	2	23563309
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CACNB1 KCNB1 ATRX SAFB2	1.11e-03	231	68	4	16452087
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	SLC5A5 SLC5A6 TFRC	1.16e-03	105	68	3	30280653
Pubmed	The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.	SREBF1 TXNRD2	1.28e-03	27	68	2	26469385
Pubmed	Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.	MIB1 POLA2	1.38e-03	28	68	2	34232536
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRNP1 KLHL25 CELSR3 SREBF1 AKNA TXNRD2 MBD6 ENDOG	1.39e-03	1105	68	8	35748872
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	NOLC1 SAFB2 RBM5 SCAF11	1.50e-03	251	68	4	31076518
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	ATRX TFRC	1.80e-03	32	68	2	19538749
Pubmed	Human transcription factor protein interaction networks.	NOLC1 IRF2BP2 ATRX TNRC6B SCAF11 MBD6 NXF1 TFRC FBXW7	1.81e-03	1429	68	9	35140242
Pubmed	Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.	HLCS TXNRD2	1.91e-03	33	68	2	10704284
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH22 ENC1 TXNRD2 SLC25A25 PDE11A	5.73e-06	167	68	5	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH22 ENC1 TXNRD2 SLC25A25 PDE11A	5.73e-06	167	68	5	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH22 ENC1 TXNRD2 SLC25A25 PDE11A	5.73e-06	167	68	5	5e3588eee73693a996bb4846427cf0038ceafbca
Disease	Malignant Glioma	SLC5A5 ATRX TFRC FBXW7	1.37e-05	70	61	4	C0555198
Disease	mixed gliomas	SLC5A5 ATRX TFRC FBXW7	1.37e-05	70	61	4	C0259783
Disease	Glioma	SLC5A5 ATRX TFRC FBXW7	3.24e-05	87	61	4	C0017638
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	MCM8 TNRC6B	1.87e-04	10	61	2	EFO_1000650, HP_0000131
Disease	Common variable immunodeficiency	IRF2BP2 CD19	3.23e-04	13	61	2	cv:C0009447
Disease	Common Variable Immunodeficiency	IRF2BP2 CD19	4.34e-04	15	61	2	C0009447
Disease	non-alcoholic fatty liver disease	AKNA KANK4 TMC4 ALPK2	5.55e-04	182	61	4	EFO_0003095
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MCM8 TNRC6B	6.30e-04	18	61	2	EFO_1000649, HP_0000131
Disease	muscular atrophy (biomarker_via_orthology)	ENDOG TFRC	1.65e-03	29	61	2	DOID:767 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EARRGHAQLGGWNGI	ARSF	351	P54793
LGRNKNELEGWGRGV	CACNB1	581	Q02641
EGAGQRSGWGTRVSV	ALPK2	1181	Q86TB3
TKGRQVGSGGDGERW	ACBD5	421	Q5T8D3
KLAVERGWAINVGGG	HDAC11	126	Q96DB2
TERGSCGRKGSGWVQ	ADAM11	576	O75078
LAERWNLKGVAGSGG	CAPN10	181	Q9HC96
AGSGGQQDRPGRWEH	CAPN10	191	Q9HC96
AKRGAAGDWGERANQ	NOLC1	646	Q14978
EGKGPVRGRVQSFWG	LY6G6F	161	Q5SQ64
WAGVAKGVGTQRIIG	DDI1	286	Q8WTU0
LKWGTRGGFNGQMER	MBD6	891	Q96DN6
GGRISGSVAWRVARG	NGLY1	456	Q96IV0
QSWKRGRGGGNFSGK	MCM8	16	Q9UJA3
GRGGGNFSGKWRERE	MCM8	21	Q9UJA3
SRGGKRNGVVDAWAG	SPN	291	P16150
NGGNFGRKEKNGWRT	GPBP1	61	Q86WP2
GRKEKNGWRTHGRNG	GPBP1	66	Q86WP2
GDWNRGGGVRVASVQ	MAPK15	471	Q8TD08
TREVKGPWGSRAGTG	KCNT1	1046	Q5JUK3
RQTEGKGRGGNVWLS	HLCS	501	P50747
WKYGEGNRRSGRGGS	NXF1	31	Q9UBU9
SKGSWGFNVRGLRGR	OR51T1	311	Q8NGJ9
SWAGGSRGDGNLQRR	PDE11A	101	Q9HCR9
RAGSEQKGWGRVGQI	PDZK1P1	136	A8MUH7
LQAMGWREGSGLGRK	RBM5	751	P52756
WREGSGLGRKCQGIT	RBM5	756	P52756
WGKQDGGEGHVGTVR	MIB1	26	Q86YT6
VQVAVGARGEARGAW	NTN3	466	O00634
VVTCLGNWFGKGRRG	SLC37A1	176	P57057
KVWNSRSRGGGEGNV	ATRX	1956	P46100
GRGLNVGARAWDKGE	CSGALNACT2	346	Q8N6G5
WRGALGASGGRFVEA	KCNB1	626	Q14721
GGRGSENGVSKDVWV	KLHL25	346	Q9H0H3
KGVRVLGGDRSLWQG	CCER2	186	I3L3R5
LGRAQRWAAGLGGTA	CD19	361	P15391
GGGGNRKASSRIWDD	DHX57	46	Q6P158
RATGRGTGKAAGIWK	HAP1	116	P54257
GAQLRAGWVRGAAVG	TMEM132E-DT	101	A2RUQ5
GGSGGVVWRIRASNT	FBXW7	666	Q969H0
AARDGKRGVGSAGWP	AKNA	1196	Q7Z591
TRGAGGFLWGSDRKT	KANK4	516	Q5T7N3
QDGALGAGRVKRGWV	CDH22	51	Q9UJ99
GGRGSENGVSKDVWV	ENC1	346	O14682
GELWATGSKGQGERA	CELSR3	206	Q9NYQ7
VAGWGSQRSGGRLSR	AZU1	151	P20160
KNFGSGWVSNRGRGR	SCAF11	1061	Q99590
RKRAAQLGGGCGWRT	FAM87A	31	P0C7U9
GAGKSRGSGEQDWVN	IRF2BP2	286	Q7Z5L9
AGGWAAALDSRKGGE	GGT2P	551	P36268
LKGRGRLFWGGSVQG	MIA	76	Q16674
RAGAGSGAGGERWQR	SNTA1	16	Q13424
GSAKVGGLGRVWAVA	SLC5A6	221	Q9Y289
ASGAGLGAVVEGWRR	ENDOG	11	Q14249
SWSGRGGAGNISLKV	POLA2	181	Q14181
GAQRDAWGPGAAKSG	TFRC	406	P02786
VGRWLAGRAGGLQQD	SREBF1	641	P36956
NFGAWAPRKGAARVG	PAK6-AS1	36	Q8N910
EGGARSLWRGNGINV	SLC25A25	236	Q6KCM7
GLWVGLARGGQRSAE	SLC5A5	31	Q92911
WRGKGVRAQQRGGSG	SOGA3	196	Q5TF21
AWTLKRIGGQFGAGT	TMC4	146	Q7Z404
GGRNRRALGEANGVW	TMEM214	31	Q6NUQ4
DEKGRVGSGSGRNLW	SAFB2	396	Q14151
KVWGSSAGRIEPRGG	TNFRSF10A	36	O00220
RWRTQAVAGGVRGAA	TXNRD2	16	Q9NNW7
RVQQHNGGRKKGGAW	SLX1A	41	Q9BQ83
NGGRKKGGAWRTSGR	SLX1A	46	Q9BQ83
QRWRQGASGIAGLAG	TRNP1	71	Q6NT89
DRKTGSVGSWGAARG	TNRC6B	416	Q9UPQ9
GGVGWRGRADGARQQ	TUSC1	46	Q2TAM9
KGKGAAGGSWQQRGR	ZAR1	31	Q86SH2
QFRVKKEGWGGGGTR	MYO1F	876	O00160
HGIEAAWAGGRNGRE	N6AMT1	136	Q9Y5N5