Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	2.23e-09	431	82	14	GO:0004984
GeneOntologyMolecularFunction	procollagen galactosyltransferase activity	CERCAM COLGALT2 COLGALT1	2.66e-07	4	82	3	GO:0050211
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GPR83 OR51S1 OR10J5 GPR65 AXL OR5AN1 OR13A1 OR4E2 PLXNA4 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 HTR3B OR2T10 OR2T34 OR5K1 ABCA7 OR4K14	3.91e-07	1353	82	20	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	5.11e-07	884	82	16	GO:0004930
GeneOntologyMolecularFunction	odorant binding	OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR5K2 OR5K1	9.12e-07	127	82	7	GO:0005549
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3 RRN3P2	9.94e-05	4	82	2	GO:0001042
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	CERCAM COLGALT2 COLGALT1	3.04e-04	32	82	3	GO:0035250
GeneOntologyMolecularFunction	galactosyltransferase activity	CERCAM COLGALT2 COLGALT1	3.97e-04	35	82	3	GO:0008378
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	RRN3 RRN3P2	5.89e-04	9	82	2	GO:0001181
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	RRN3 RRN3P2 DHX9	8.36e-04	45	82	3	GO:0043175
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	RRN3 RRN3P2	8.94e-04	11	82	2	GO:0001164
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	RRN3 RRN3P2	1.26e-03	13	82	2	GO:0001163
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	1.09e-09	432	80	14	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	2.80e-09	465	80	14	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	4.79e-09	485	80	14	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	1.27e-08	524	80	14	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	2.18e-08	547	80	14	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	4.72e-08	582	80	14	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 RP1 OR2T10 OR2T34 OR5K1 OR4K14	1.01e-07	722	80	15	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	ADCY10 GPR83 OR51S1 GTF2H2 OR10J5 GPR65 RAPGEF3 OR5AN1 OR13A1 OR4E2 OR14J1 PRKCB OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	2.47e-07	1395	80	20	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 ELMOD3 OR2J1 OR5K2 OR2J2 RP1 OR2T10 OR2T34 OR5K1 PKHD1L1 OR4K14	5.91e-07	1072	80	17	GO:0007600
MousePheno	delayed gastrulation	USP9X DHX9	9.41e-05	4	56	2	MP:0012105
MousePheno	abnormal pancreatic islet morphology	ILDR2 RAPGEF3 SGPP2 WDR13 SEC23B NCOA5	1.08e-04	190	56	6	MP:0005215
MousePheno	abnormal endocrine pancreas morphology	ILDR2 RAPGEF3 SGPP2 WDR13 SEC23B NCOA5	1.11e-04	191	56	6	MP:0009165
Domain	Olfact_rcpt	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	1.88e-09	393	83	14	IPR000725
Domain	7tm_1	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	4.01e-08	677	83	16	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	4.72e-08	685	83	16	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	5.32e-08	691	83	16	PS50262
Domain	GPCR_Rhodpsn	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	5.43e-08	692	83	16	IPR000276
Domain	Glyco_trans_25	CERCAM COLGALT2 COLGALT1	8.46e-08	3	83	3	IPR002654
Domain	Glyco_transf_25	CERCAM COLGALT2 COLGALT1	8.46e-08	3	83	3	PF01755
Domain	GPCR_Rhodpsn_7TM	GPR83 OR51S1 OR10J5 GPR65 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	2.27e-07	670	83	15	IPR017452
Domain	ER_TARGET	CERCAM COLGALT2 COLGALT1	1.19e-03	47	83	3	PS00014
Domain	NPIP	NPIPB13 NPIPB5	1.72e-03	14	83	2	IPR009443
Domain	Cyclophilin-type_PPIase_CS	PPIE PPIF	3.18e-03	19	83	2	IPR020892
Domain	Cyclophilin-type_PPIase	PPIE PPIF	3.88e-03	21	83	2	IPR024936
Domain	DEP	PIKFYVE RAPGEF3	4.25e-03	22	83	2	PF00610
Domain	Cyclophilin-like_dom	PPIE PPIF	4.25e-03	22	83	2	IPR029000
Domain	DEP	PIKFYVE RAPGEF3	4.25e-03	22	83	2	PS50186
Domain	CSA_PPIASE_2	PPIE PPIF	4.25e-03	22	83	2	PS50072
Domain	Cupredoxin	HEPHL1 PKHD1L1	4.25e-03	22	83	2	IPR008972
Domain	Pro_isomerase	PPIE PPIF	4.25e-03	22	83	2	PF00160
Domain	-	PPIE PPIF	4.25e-03	22	83	2	2.40.100.10
Domain	DEP	PIKFYVE RAPGEF3	4.25e-03	22	83	2	SM00049
Domain	Cyclophilin-type_PPIase_dom	PPIE PPIF	4.25e-03	22	83	2	IPR002130
Domain	CSA_PPIASE_1	PPIE PPIF	4.25e-03	22	83	2	PS00170
Domain	DEP_dom	PIKFYVE RAPGEF3	4.65e-03	23	83	2	IPR000591
Domain	Metal_Hydrolase	CAD ADA2	5.05e-03	24	83	2	IPR032466
Domain	GroES-like	ZDHHC6 ABCA7	5.05e-03	24	83	2	IPR011032
Domain	HECT	HACE1 HERC2	6.37e-03	27	83	2	PF00632
Domain	HECTc	HACE1 HERC2	6.37e-03	27	83	2	SM00119
Domain	HECT_dom	HACE1 HERC2	6.37e-03	27	83	2	IPR000569
Domain	IPT	PLXNA4 PKHD1L1	6.37e-03	27	83	2	SM00429
Domain	HECT	HACE1 HERC2	6.37e-03	27	83	2	PS50237
Domain	Nucleotide-diphossugar_trans	CERCAM COLGALT2 COLGALT1	7.08e-03	88	83	3	IPR029044
Domain	TIG	PLXNA4 PKHD1L1	8.35e-03	31	83	2	PF01833
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	4.87e-09	417	65	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	1.97e-08	389	65	13	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR10J5 OR14J1 OR2J1 OR5K2 OR2J2 OR5K1	7.90e-07	70	65	6	MM14984
Pathway	REACTOME_SENSORY_PERCEPTION	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	9.06e-07	636	65	14	M41834
Pathway	REACTOME_SENSORY_PERCEPTION	OR10J5 OR14J1 OR2J1 OR5K2 OR2J2 OR5K1	2.36e-04	190	65	6	MM15687
Pubmed	The human olfactory receptor gene family.	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR2T10 OR2T34 OR5K1 OR4K14	6.70e-11	541	86	14	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR5K1	8.45e-10	340	86	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR5K1	8.45e-10	340	86	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR5K1	9.26e-10	343	86	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51S1 OR10J5 OR5AN1 OR13A1 OR4E2 OR14J1 OR13G1 OR2J1 OR5K2 OR2J2 OR5K1	1.01e-09	346	86	11	14611657
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR14J1 OR2J1 OR2J2	4.10e-06	13	86	3	14506126
Pubmed	Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.	RRN3 RRN3P2	6.04e-06	2	86	2	12015311
Pubmed	Collagen glycosylation.	COLGALT2 COLGALT1	6.04e-06	2	86	2	30822656
Pubmed	A neuroprotective phase precedes striatal degeneration upon nucleolar stress.	RRN3 RRN3P2	6.04e-06	2	86	2	23764776
Pubmed	Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.	COLGALT2 COLGALT1	6.04e-06	2	86	2	19075007
Pubmed	Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.	RRN3 RRN3P2	6.04e-06	2	86	2	31110473
Pubmed	Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.	RRN3 RRN3P2	6.04e-06	2	86	2	38745938
Pubmed	DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.	RRN3 RRN3P2	6.04e-06	2	86	2	23393135
Pubmed	Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter.	RRN3 RRN3P2	6.04e-06	2	86	2	8413268
Pubmed	Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.	RRN3 RRN3P2	6.04e-06	2	86	2	30918302
Pubmed	Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.	RRN3 RRN3P2	6.04e-06	2	86	2	24273493
Pubmed	Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.	RRN3 RRN3P2	6.04e-06	2	86	2	27257073
Pubmed	ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.	RRN3 RRN3P2	6.04e-06	2	86	2	12620228
Pubmed	TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.	RRN3 RRN3P2	1.81e-05	3	86	2	19217408
Pubmed	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.	RRN3 RRN3P2	1.81e-05	3	86	2	34880223
Pubmed	Implausibility of the vibrational theory of olfaction.	OR5AN1 OR4E2	1.81e-05	3	86	2	25901328
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner.	HCN3 NCOA5	1.81e-05	3	86	2	37733590
Pubmed	Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.	RRN3 RRN3P2	3.61e-05	4	86	2	24297901
Pubmed	Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.	RRN3 RRN3P2	3.61e-05	4	86	2	28360124
Pubmed	Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.	RRN3 RRN3P2	6.01e-05	5	86	2	18559419
Pubmed	The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.	RRN3 RRN3P2	6.01e-05	5	86	2	15805466
Pubmed	Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.	RRN3 RRN3P2	6.01e-05	5	86	2	21228155
Pubmed	Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.	RRN3 RRN3P2	6.01e-05	5	86	2	19036968
Pubmed	CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR.	HACE1 DHX9	9.01e-05	6	86	2	36038948
Pubmed	Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.	ADAMTS19 USP9X	9.01e-05	6	86	2	19508998
Pubmed	Nuclear actin and myosin I are required for RNA polymerase I transcription.	RRN3 RRN3P2	1.26e-04	7	86	2	15558034
Pubmed	A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.	RRN3 RRN3P2	1.26e-04	7	86	2	28715449
Pubmed	Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction.	HCN3 PRKCB	1.26e-04	7	86	2	29436516
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GPR83 RELCH HCN3 CERCAM	1.28e-04	103	86	4	10819331
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	CAD USP9X CNOT1 DYNC1H1 DHX9	1.33e-04	197	86	5	31620119
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CAD HEATR6 HERC2 CNOT1 DHX9	1.50e-04	202	86	5	33005030
Pubmed	Diversity of oligosaccharide structures on the envelope glycoprotein gp 120 of human immunodeficiency virus 1 from the lymphoblastoid cell line H9. Presence of complex-type oligosaccharides with bisecting N-acetylglucosamine residues.	COLGALT2 COLGALT1	1.68e-04	8	86	2	2341393
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	CAD AP2A2 CNOT1	1.80e-04	44	86	3	26471122
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	SLC12A6 CAD USP9X CNOT1 DYNC1H1 SEC23B DHX9	2.02e-04	484	86	7	31995728
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SLC12A6 ILDR2 PHLDB1 CAD AP2A2 USP9X PLXNA4 PRKCB CNOT1 DYNC1H1 RHOT1 DHX9	2.06e-04	1431	86	12	37142655
Pubmed	aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.	AP2A2 PRKCB	2.15e-04	9	86	2	17203073
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	CAD HACE1 CNOT1 DYNC1H1 DHX9	2.27e-04	221	86	5	29991511
Pubmed	Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.	USP9X PRKCB	2.68e-04	10	86	2	26936881
Pubmed	Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.	RRN3 RRN3P2	3.93e-04	12	86	2	15989966
Pubmed	Collagen XIV is important for growth and structural integrity of the myocardium.	COLGALT2 COLGALT1	3.93e-04	12	86	2	22906538
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	AP2A2 AXL USP9X	4.97e-04	62	86	3	31340145
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	CAD AP2A2 USP9X CNOT1 DYNC1H1	5.30e-04	266	86	5	19380743
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	USP9X HERC2	5.39e-04	14	86	2	27626314
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	CAD DYNC1H1 DHX9	5.45e-04	64	86	3	22865885
Pubmed	Defining the membrane proteome of NK cells.	SLC37A1 CAD USP9X OAS2 HERC2 COLGALT1 CNOT1 DYNC1H1 RHOT1 DHX9	6.16e-04	1168	86	10	19946888
Pubmed	Proteomic analysis of an interactome for long-form AMPA receptor subunits.	CAD DHX9	6.21e-04	15	86	2	20131911
Pubmed	Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.	PPIE PPIF	6.21e-04	15	86	2	20676357
Pubmed	IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.	USP9X DYNC1H1	6.21e-04	15	86	2	18303054
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CAD AP2A2 USP9X HCN3 HECTD4 PRKCB HERC2 CNOT1 DYNC1H1	6.31e-04	963	86	9	28671696
Pubmed	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.	AP2A2 PRKCB	7.09e-04	16	86	2	16055064
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	HERC2 DYNC1H1 SEC23B	9.01e-04	76	86	3	27542412
Pubmed	Rrn3 becomes inactivated in the process of ribosomal DNA transcription.	GTF2H2 RRN3	1.01e-03	19	86	2	12646563
Pubmed	HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion.	AP2A2 HACE1	1.01e-03	19	86	2	26343856
Pubmed	Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types.	GPR65 HTR3B	1.01e-03	19	86	2	36973009
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	USP9X HERC2 ABCA7	1.20e-03	84	86	3	15203218
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	RELCH CAD DYNC1H1	1.20e-03	84	86	3	29563501
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	HERC2 NCOA5	1.23e-03	21	86	2	37422473
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	AXL USP9X	1.23e-03	21	86	2	29416926
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	CERCAM COLGALT1	1.23e-03	21	86	2	23097496
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	CAD HECTD4 DYNC1H1 DHX9	1.29e-03	190	86	4	15161933
Pubmed	A proteomic analysis of human bile.	IGHA1 APOH	1.35e-03	22	86	2	15084671
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	USP9X SEC23B	1.35e-03	22	86	2	35120648
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	USP9X DENND6B PIGV CNOT1 DYNC1H1	1.42e-03	332	86	5	37433992
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	GTF2H2 RRN3	1.48e-03	23	86	2	12393749
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	SNX14 SPARC AP2A2 AXL TMEM175 RHOT1	1.51e-03	499	86	6	22810586
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	DYNC1H1 DHX9	1.61e-03	24	86	2	33705438
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	HACE1 HECTD4 HERC2	1.71e-03	95	86	3	29643511
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	COLGALT2 COLGALT1	1.75e-03	25	86	2	2283726
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HACE1 HERC2	1.89e-03	26	86	2	26949039
Pubmed	No death without life: vital functions of apoptotic effectors.	CASP12 PPIF	1.89e-03	26	86	2	18309324
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	COLGALT2 COLGALT1	1.89e-03	26	86	2	8218172
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	CAD AP2A2 COLGALT1 DYNC1H1 SEC23B RHOT1 DHX9	2.15e-03	725	86	7	27025967
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	CAD DYNC1H1 DHX9	2.22e-03	104	86	3	36055981
Cytoband	15q13	SLC12A6 HERC2	1.24e-04	9	86	2	15q13
Cytoband	16p11.2	NPIPB13 NPIPB12 RRN3P2 PRKCB	4.72e-04	191	86	4	16p11.2
Cytoband	1q25	COLGALT2 DHX9	1.09e-03	26	86	2	1q25
Cytoband	3q11.2	OR5K2 OR5K1	1.09e-03	26	86	2	3q11.2
Cytoband	1q44	OR13G1 OR2T10 OR2T34	1.19e-03	110	86	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR13G1 OR2T10 OR2T34	1.83e-03	128	86	3	chr1q44
Cytoband	22q13.33	SELENOO DENND6B	2.33e-03	38	86	2	22q13.33
GeneFamily	Collagen beta(1-O)galactosyltransferases	COLGALT2 COLGALT1	1.19e-05	2	63	2	439
GeneFamily	Olfactory receptors, family 2	OR2J1 OR2J2 OR2T10 OR2T34	6.49e-04	113	63	4	149
GeneFamily	Cyclophilin peptidylprolyl isomerases	PPIE PPIF	1.97e-03	19	63	2	909
GeneFamily	Olfactory receptors, family 13	OR13A1 OR13G1	2.88e-03	23	63	2	162
GeneFamily	Selenoproteins	SELENOO TXNRD2	3.40e-03	25	63	2	890
Coexpression	GSE31082_DP_VS_CD8_SP_THYMOCYTE_DN	GPR83 CAD AXL HCN3 OAS2 RP1 TXNRD2	3.18e-06	200	82	7	M5068
Disease	diet measurement, HOMA-B	PCNX2 PLXNA4	1.20e-03	19	80	2	EFO_0004469, EFO_0008111
Disease	Osteogenesis imperfecta	PHLDB1 SPARC	1.47e-03	21	80	2	cv:C0029434
Disease	Arthrogryposis	VPS8 DYNC1H1	1.47e-03	21	80	2	C0003886

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRHHIQQFPFCLMSV	ELMOD3	241	Q96FG2
MISPVLILFSSFLCH	APOH	1	P02749
FCAQTFLLSPLHMTK	TBC1D32	236	Q96NH3
VGSTPLIGHFFTICM	HTR3B	296	O95264
HQMLVRCAAIIGLTF	ADCY10	826	Q96PN6
LFRCFRPVLTHMQTL	DENND6B	251	Q8NEG7
FLVFMSHSILNGICG	CASP12	166	Q6UXS9
FPHFCLGRGLIDMVR	ABCA7	1691	Q8IZY2
ASRNPTFMGLALHCI	AP2A2	121	O94973
SMIHVGLVFRLVFCG	OR5K2	156	Q8NHB8
ILFGPLASFCQEMQH	ADAMTS19	571	Q8TE59
SVCGFRFHHQPMIIS	NPIPB12	491	F8W0I5
SPAFHQALLSFCRMS	RELCH	486	Q9P260
HTALIMRLTFCGPNT	OR13G1	156	Q8NGZ3
MRLTFCGPNTIDHFF	OR13G1	161	Q8NGZ3
TCGAHLMVVSLFFIP	OR2J1	241	Q9GZK6
APVHSSMFRFLGVLL	HERC2	4526	O95714
SVHTRVNQPGMLCSF	DCAF4L1	166	Q3SXM0
IFNVAIPRFHMACPT	FBXO3	391	Q9UK99
IPRFHMACPTFRVSI	FBXO3	396	Q9UK99
SMQHIPALFSAFCGL	PCNX2	1026	A6NKB5
VVMFGKQPCLFHRRS	PLXNA4	986	Q9HCM2
FKQHFMDSRIPCLIV	RHOT1	511	Q8IXI2
MHAAINFSIPLCGKR	OR14J1	156	Q9UGF5
PASACLLQMVFIHVF	OR51S1	101	Q8NGJ8
CSAHIMVVTLFFGPC	OR4K14	241	Q8NGD5
QIHRSCTVNIMFGTP	NCOA5	261	Q9HCD5
MFCHVFRIGPSSPSN	HACE1	326	Q8IYU2
TPFSVMIACSIRELH	HEATR6	506	Q6AI08
LSVCGFRFHHQPMII	NPIPB5	611	A8MRT5
PFLTQLHSCFQTMDR	PRKCB	401	P05771
TISPSGCGIQMFFHL	OR2T34	96	Q8NGX1
TCGAHLMVVSLFFIP	OR2J2	241	O76002
NFTCRGLVAHMPLFA	HCN3	416	Q9P1Z3
RVFPPVRACMFSSHL	HECTD4	1946	Q9Y4D8
CGARIHPIVNEMFSS	OAS2	691	P29728
MATFFSLPHAICQKL	GPR83	196	Q9NYM4
GSNVIRHFFCDMPQL	OR5AN1	171	Q8NGI8
SMIHVGLVFRLVFCG	OR5K1	156	Q8NHB7
PIAMSFPFCRSHEIQ	OR2T10	161	Q8NGZ9
QTKTLMFFEGCPQHL	PIKFYVE	821	Q9Y2I7
AAMGIVCFLFLIEHP	SLC37A1	231	P57057
FSCMVGHEALPLAFT	IGHA1	311	P01876
ICFTPRGIMQFRFAH	ADA2	136	Q9NZK5
AFMQPDHAGIFRVFC	HEPHL1	686	Q6MZM0
LQPHACFRLFLTMEI	DYNC1H1	4116	Q14204
TTGMFPQEFIICFHK	HSPB11	41	Q9Y547
RGCFAVPMVHSTFLI	COLGALT1	226	Q8NBJ5
RTGCFPVPMVHSTFL	COLGALT2	226	Q8IYK4
GCFRVPMVHSTFLAS	CERCAM	206	Q5T4B2
PTMFQHGRTSEFLLR	CAPN6	471	Q9Y6Q1
GSSFHRIIPQFMCQG	PPIE	186	Q9UNP9
HFPVCMLGNRTLSSR	SLC12A6	371	Q9UHW9
RPHASIMFCTVGVLL	DHX9	481	Q08211
LSVCGFRFHHQPMII	NPIPB13	616	A6NJU9
MLRLDFCGPNVIIHF	OR13A1	181	Q8NGR1
RFCMNFLHTSLLVVG	RP1	2031	P56715
AVLHVTAMFNLPFCG	OR10J5	156	Q8NHC4
TVFLRPCLSMIASHF	RRN3	141	Q9NYV6
ECSLIRMGFPQHTIA	GTF2H2C;	246	Q6P1K8
TRCCMGHRPLLFFIT	USP9X	1341	Q93008
LCSEAMFHLGVPTTR	SELENOO	201	Q9BVL4
TMVVAGIFLLIRFHP	MT-ND5	251	P03915
HPVRSIFCPLMSFRQ	WDR13	406	Q9H1Z4
NPMLAFCRGDVVHFL	VPS8	366	Q8N3P4
KGSTFHRVIPSFMCQ	PPIF	91	P30405
HRVIPSFMCQAGDFT	PPIF	96	P30405
LITFGRMVQVHELSC	SEC23B	166	Q15437
VGICATTFVPMLHRF	SGPP2	381	Q8IWX5
HLNPAVTFAMCFLAR	AQP3	81	Q92482
REHGEPFIQACMTFL	CNOT1	606	A5YKK6
LFGGLCMHVQVLTRF	PIGV	391	Q9NUD9
APLGCIHAAFIFVMT	ZDHHC6	151	Q9H6R6
FLLTHRVFMPSAQLC	RAPGEF3	421	O95398
GIFHLMQIAVPCAFL	TMEM175	446	Q9BSA9
SAHFMVVALFFGPCI	OR4E2	241	Q8NGC2
VLSLLENVFTPMFCH	SNX14	446	Q9Y5W7
ECSLIRMGFPQHTIA	GTF2H2	246	Q13888
VAMLFQPTVLRCHFS	ILDR2	31	Q71H61
RAPLIPMEHCTTRFF	SPARC	256	P09486
MCSHFTQDFLPVQGI	ZNF721	1	Q8TF20
EFDHPNVMRLIGVCF	AXL	591	P30530
GIMVLPRQTCGLFTH	NDST2	476	P52849
PAVTMLGFGFLCHSQ	TMEM88	56	Q6PEY1
VHFMNFDRPNCVALG	PKHD1L1	2741	Q86WI1
MLCLGQSTFLRFNHP	PHLDB1	121	Q86UU1
TVFLRPCLSMIASHF	RRN3P2	141	A6NIE6
VLCFTPFHVMLLIRC	GPR65	236	Q8IYL9
CFGQFILTPHIMTRA	CAD	2161	P27708
HIMLTFSLRPFGCGI	ZBTB9	401	Q96C00
SYAQVMRTVGIHPTC	TXNRD2	486	Q9NNW7
FGEVLFRESVPMHTC	ZSWIM4	531	Q9H7M6