Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainABC_A

ABCA1 ABCA9

3.21e-0412422IPR026082
DomainAAA+_ATPase

ABCA1 MDN1 ABCA9

4.14e-03144423IPR003593
DomainAAA

ABCA1 MDN1 ABCA9

4.14e-03144423SM00382
DomainABC_TRANSPORTER_2

ABCA1 ABCA9

5.22e-0348422PS50893
DomainABC_tran

ABCA1 ABCA9

5.22e-0348422PF00005
DomainABC_TRANSPORTER_1

ABCA1 ABCA9

5.43e-0349422PS00211
DomainABC_transporter-like

ABCA1 ABCA9

5.65e-0350422IPR003439
Domain-

NLRP1 ABCA1 MDN1 MPP4 ABCA9 AK7

6.12e-037464263.40.50.300
DomainZinc_finger_PHD-type_CS

INTS12 SP110

9.39e-0365422IPR019786
DomainP-loop_NTPase

NLRP1 ABCA1 MDN1 MPP4 ABCA9 AK7

1.12e-02848426IPR027417
DomainPrefoldin

HIP1 WTAP

1.14e-0272422IPR009053
DomainPHD

INTS12 SP110

1.23e-0275422PF00628
DomainZnf_PHD-finger

INTS12 SP110

1.36e-0279422IPR019787
Pubmed

Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.

ABCA1 ABCA9

1.78e-05547212532264
Pubmed

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.

HIP1 VAMP7

1.78e-05547234821552
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

TICRR ZC3H11A SUPT20H MDN1 INTS12 SP110 NIPBL ESCO1 WTAP

5.05e-05129447930804502
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

ZC3H11A INTS12 NIPBL

2.19e-048647337253089
Pubmed

Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion.

GOLGA8B VAMP7

2.70e-041847222718342
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

NLRP1 DZIP1 AMOTL2

3.62e-0410247310231032
Pubmed

Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.

OPN4 CCDC136

4.44e-042347226965927
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

NARS1 TICRR MDN1 AMOTL2 ESCO1 DENND4B

4.52e-0473647629676528
Pubmed

Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5.

OPN4 GAP43

5.69e-042647218787067
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

HIP1 ZC3H11A MPHOSPH6 SUPT20H CCDC137 MDN1 INTS12 NIPBL

8.13e-04149747831527615
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

TBC1D10C ZC3H11A MPHOSPH6 CCDC137 MDN1 WTAP

9.40e-0484747635850772
Pubmed

Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.

GATA3 GOLGA8B

9.75e-043447219956733
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

ZC3H11A SP110

9.75e-043447225925205
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

NARS1 ZC3H11A MDN1 NIPBL

1.05e-0333247432786267
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

PDE4B CCDC88A CCDC136

1.13e-0315147317043677
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

AMOTL2 GCC2

1.35e-034047228805822
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA9

1.93e-0414272805
GeneFamilyZinc fingers CCCH-type

ZC3H11B ZC3H11A

1.24e-033527273
CoexpressionGSE21927_SPLEEN_VS_C26GM_TUMOR_MONOCYTE_BALBC_DN

ZFAND3 HIP1 AMOTL2 ESCO1 CCDC136

2.51e-05194475M7573
CoexpressionGSE24634_NAIVE_CD4_TCELL_VS_DAY3_IL4_CONV_TREG_UP

NLRP1 ZFAND3 PDE4B GCC2 WTAP

2.77e-05198475M4586
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

GATA3 ZC3H11A CCDC88A MPHOSPH6 NIPBL GCC2

6.41e-0819947619674e1eaeb51e4196d847cb62aa437c852951d3
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA3 TBC1D10C CCDC88A CCDC180 CCDC136

1.23e-0617847509d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA3 TBC1D10C CCDC136 WTAP

2.44e-051604741cb6f42b68c9e41e8edae0de8f0d8371c4620b04
ToppCellfacs-Liver-Liver_non-hepato/SCs|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA3 TBC1D10C CCDC136 WTAP

2.44e-05160474ebefde92db400cbe68d9ce31545a0308e0afbde1
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GATA3 TBC1D10C GOLGA8B PDE4B

3.46e-0517547406eace2e681980456299167b48bd49bcfea5e940
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GATA3 HIP1 PDE4B GAP43

3.54e-0517647477516048aefbe1f48e825052756df0c310c1c486
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88A SUPT20H ABCA9 ESCO1

3.54e-05176474749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GATA3 HIP1 PDE4B GAP43

3.54e-0517647496779273b94345250cf53ba671203345b43d9e00
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88A NIPBL ABCA9 GCC2

4.03e-05182474f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC88A NIPBL ABCA9 GCC2

4.30e-051854747adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GOLGA8B PDE4B ESCO1 CCDC136

4.77e-0519047491ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellcritical-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ZNF704 AMOTL2 IDI2-AS1 ABCA9

5.07e-051934746be11fef87af04ee7a3cc223882ccd4077caded9
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA1 PDE4B CCDC88A WTAP

5.38e-0519647401cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GATA3 TBC1D10C GOLGA8B GCC2

5.49e-0519747459b1fb93a39dcf8c994d2b7dc2906dae74c57527
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D231|Adult / Lineage, Cell type, age group and donor

ABCA1 PDE4B CCDC88A MPHOSPH6

5.60e-0519847479a415e19cedde13a88f5043d71557363f102322
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GATA3 TBC1D10C GOLGA8B GCC2

5.60e-051984747df4608e2d841c405565ad9c4f4fa8d8ae3a2be5
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

ZC3H11A CCDC88A NIPBL GCC2

5.60e-0519847476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

ZNF704 CCDC88A NIPBL GCC2

5.71e-0519947418a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

GATA3 ZC3H11A NIPBL GCC2

5.71e-0519947453ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

GATA3 CCDC88A NIPBL GCC2

5.71e-05199474a2f7d0cabf35b80fe239fae34a77bf9344d5d743
Drugdihydrosqualene

NLRP1 ABCA1

3.82e-062452CID005366021
DiseaseHodgkin Disease

GATA3 GAP43

4.93e-0422442C0019829
Diseasecorneal resistance factor

ZC3H11B HIP1 ABCA9 DCAF4 DENND4B

5.42e-04451445EFO_0010067
DiseaseDNA methylation

NLRP1 ABCA1 HIP1 MDN1 GAP43

2.84e-03656445GO_0006306

Protein segments in the cluster

PeptideGeneStartEntry
MRSRQEMKNPISNKK

CCDC137

71

Q6PK04
SSKREALEKTMRNKM

AMOTL2

366

Q9Y2J4
LSCMERKKVQIRSMD

DCAF4

151

Q8WV16
RCLEMNCRKKLMRKD

ABCA9

1221

Q8IUA7
SQKDTSMKDMRKVLR

ABCA1

116

O95477
MIRMNKEKLEECTRR

CCDC180

1531

Q9P1Z9
RKMCRKLLDMTFSSK

ADAMTS13

1251

Q76LX8
RCTRQMKRMAQKTQK

INTS12

211

Q96CB8
RKRMRKMCLTFMKES

MDN1

4061

Q9NU22
MKMKLFQTICRQLRS

MGME1

1

Q9BQP7
LRRNVESLKCASMKM

CCDC88A

706

Q3V6T2
MNLTKKQRQTLRKMV

PDE4B

496

Q07343
ACTCLMQQMKRKEKL

NLRP1

526

Q9C000
STMPLCERVKMNKRK

NIPBL

1061

Q6KC79
KPSNMRCMKQSRKNA

MPP4

546

Q96JB8
NMRKQKTLCDVILMV

KLHL7

36

Q8IXQ5
NKDMKVAMRRLCSRL

OR4F15

291

Q8NGB8
QRLQSECKMAKIMLL

OPN4

286

Q9UHM6
IQTRNRKMSSKSKKC

GATA3

361

P23771
IGILMQKCRNKVMKN

GGH

36

Q92820
KQMMLIQKAKSRCTE

GCC2

36

Q8IWJ2
NRCNRKTAKQMLMTT

IDI2-AS1

121

Q9NZ38
RTKQEMKVAQRMAQK

DENND4B

741

O75064
SMMRRKKIASRMIEC

ESCO1

776

Q5FWF5
SQTGKKLMAKCRMLI

WTAP

151

Q15007
QRMRKMSQEVCTLKE

GOLGA8B

246

A8MQT2
KRLKTQMAEVRCMKT

TRIM37

676

O94972
NMSKILKARSMVTRC

NARS1

241

O43776
MLCCMRRTKQVEKND

GAP43

1

P17677
KTRLSKNLLRMKFMQ

MPHOSPH6

6

Q99547
SMCQLAKDQRKMLLV

HIP1

611

O00291
SEVMMRVQKARTKCA

SP110

406

Q9HB58
ECKRRKKMISTQQLM

DZIP1

176

Q86YF9
KCNRNKQSKLLMEQM

CCDC136

671

Q96JN2
TPVRQKMNTMCRSLK

TICRR

566

Q7Z2Z1
KMNTMCRSLKMLNVA

TICRR

571

Q7Z2Z1
KKMRNLLNSRCGIRM

TMPRSS11F

176

Q6ZWK6
KTMSRRYKKVKMQCR

TBC1D10C

76

Q8IV04
VKRCETMREKHMQKQ

ZC3H11A

556

O75152
KQKMNTRPMKRCFKR

SUPT20H

226

Q8NEM7
RNLARAMCMKNLKLT

VAMP7

176

P51809
VKRCEIMRETRMQKQ

ZC3H11B

556

A0A1B0GTU1
IPRKRKNSMKVMFKC

ZNF704

181

Q6ZNC4
MKMVKLDRKVGRSCQ

ZFAND3

206

Q9H8U3
KMRMQRIKVCEKRPS

WFDC10B

26

Q8IUB3
LQNSSMMKKTLKCIR

TPCN2

196

Q8NHX9
QRMRKMSQEVCSLKK

GOLGA8CP

246

A6NN73
IRFMKEKLKSMPCRN

AK7

461

Q96M32