Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongroup III metabotropic glutamate receptor activity

GRM4 GRM7

8.09e-054742GO:0001642
GeneOntologyMolecularFunctioncalcium channel activity

TRPM2 TRPM1 CACHD1 PKD1L3 GRM7

1.17e-04129745GO:0005262
GeneOntologyMolecularFunctionphosphatidylserine flippase activity

ATP8A1 ATP8A2

1.35e-045742GO:0140346
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6B UTY

1.35e-045742GO:0071558
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B4 ATP8A1 ATP8A2

1.50e-0428743GO:0140326
GeneOntologyMolecularFunctiontransporter activity

ATP8B4 ATP8A1 ATP8A2 SLC2A7 TRPM2 MFSD2B TRPM1 CACHD1 PKD1L3 GRM7 SLC25A28 AQP4 MFSD1 GABRA5

2.40e-0412897414GO:0005215
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM2 TRPM1 CACHD1 PKD1L3 GRM7

2.45e-04151745GO:0015085
GeneOntologyMolecularFunctionaminophospholipid flippase activity

ATP8A1 ATP8A2

2.81e-047742GO:0015247
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM4 GRM7

4.80e-049742GO:0098988
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP8A1 ATP8A2

4.80e-049742GO:0090556
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM4 GRM7

4.80e-049742GO:0001640
GeneOntologyMolecularFunctioncalcium-dependent protein binding

NRXN1 MYO5A GRM4 GRM7

4.82e-0498744GO:0048306
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B4 ATP8A1 ATP8A2

8.95e-0451743GO:0140303
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP8A1 ATP8A2

1.20e-0314742GO:0140333
GeneOntologyMolecularFunctiontransmembrane transporter activity

ATP8A1 SLC2A7 TRPM2 MFSD2B TRPM1 CACHD1 PKD1L3 GRM7 SLC25A28 AQP4 MFSD1 GABRA5

1.25e-0311807412GO:0022857
GeneOntologyMolecularFunctionfloppase activity

ATP8A1 ATP8A2

1.57e-0316742GO:0140328
GeneOntologyMolecularFunctioncalmodulin binding

PHKA2 MYO5A GRM4 GRM7 ADCY3

1.64e-03230745GO:0005516
GeneOntologyMolecularFunctioncalcium ion binding

CELSR2 NRXN1 MYO5A UMODL1 TRPM2 PKD1L3 GRM7 CDH10 RASGRP2

1.75e-03749749GO:0005509
GeneOntologyMolecularFunctionflippase activity

ATP8A1 ATP8A2

1.78e-0317742GO:0140327
GeneOntologyMolecularFunctionchannel activity

TRPM2 TRPM1 CACHD1 PKD1L3 GRM7 AQP4 GABRA5

3.29e-03525747GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TRPM2 TRPM1 CACHD1 PKD1L3 GRM7 AQP4 GABRA5

3.32e-03526747GO:0022803
GeneOntologyBiologicalProcessG protein-coupled glutamate receptor signaling pathway

TRPM1 GRM4 GRM7

2.40e-0516743GO:0007216
GeneOntologyBiologicalProcesscerebrospinal fluid secretion

CELSR2 AQP4

7.58e-054742GO:0033326
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

NRXN1 MYO5A NR3C1 GRM4 GRM7

1.13e-04132745GO:0035249
GeneOntologyBiologicalProcesslearning

ATP8A1 NRXN1 GRM4 GRM7 ADCY3 GABRA5

1.14e-04212746GO:0007612
GeneOntologyBiologicalProcesspresynaptic active zone assembly

NRXN1 BSN

1.26e-045742GO:1904071
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP8B4 ATP8A1 ATP8A2

1.45e-0514733GO:1990531
GeneOntologyCellularComponentpresynaptic active zone

NRXN1 BSN GRM4 GRM7 CDH10

1.35e-04141735GO:0048786
GeneOntologyCellularComponentpresynaptic active zone membrane

NRXN1 GRM4 GRM7 CDH10

1.61e-0478734GO:0048787
GeneOntologyCellularComponentGABA-ergic synapse

NRXN1 BSN GRM7 CDH10 GABRA5

2.73e-04164735GO:0098982
GeneOntologyCellularComponentMLL3/4 complex

KDM6B UTY

7.76e-0412732GO:0044666
GeneOntologyCellularComponentsomatodendritic compartment

BMPR2 NRXN1 MYO5A TRPM2 DPYSL5 IREB2 TRPM1 NR3C1 BSN GRM4 GRM7 GABRA5

1.05e-0312287312GO:0036477
GeneOntologyCellularComponentGBAF complex

ACTL6B ACTL6A

1.07e-0314732GO:0140288
GeneOntologyCellularComponentbrahma complex

ACTL6B ACTL6A

1.07e-0314732GO:0035060
GeneOntologyCellularComponentRSC-type complex

ACTL6B ACTL6A

1.23e-0315732GO:0016586
GeneOntologyCellularComponentcell surface

BMPR2 NRXN1 UMODL1 CD48 BSN PKD1L3 CR1 GRM7 NFAM1 AQP4 DCBLD2

1.56e-0311117311GO:0009986
GeneOntologyCellularComponentglutamatergic synapse

ATP8A1 NRXN1 MYO5A DPYSL5 NR3C1 BSN GRM4 GRM7 CDH10

2.11e-03817739GO:0098978
GeneOntologyCellularComponentspecific granule

ATP8B4 ILF2 ATP8A1 TRPM2

2.39e-03160734GO:0042581
GeneOntologyCellularComponentneuronal cell body

BMPR2 NRXN1 MYO5A TRPM2 DPYSL5 IREB2 BSN GRM7 GABRA5

2.44e-03835739GO:0043025
GeneOntologyCellularComponenttertiary granule

ATP8B4 ILF2 TRPM2 CR1

2.61e-03164734GO:0070820
GeneOntologyCellularComponentpresynaptic membrane

NRXN1 GRM4 GRM7 CDH10 GABRA5

2.84e-03277735GO:0042734
GeneOntologyCellularComponentdendrite

BMPR2 MYO5A DPYSL5 TRPM1 NR3C1 BSN GRM4 GRM7 GABRA5

2.93e-03858739GO:0030425
GeneOntologyCellularComponentdendritic tree

BMPR2 MYO5A DPYSL5 TRPM1 NR3C1 BSN GRM4 GRM7 GABRA5

2.97e-03860739GO:0097447
DomainFAM163

FAM163B FAM163A

1.51e-052732PF15069
DomainFAM163

FAM163B FAM163A

1.51e-052732IPR029379
DomainP_typ_ATPase_c

ATP8B4 ATP8A1 ATP8A2

2.02e-0514733IPR032630
DomainP-type_ATPase_N

ATP8B4 ATP8A1 ATP8A2

2.02e-0514733IPR032631
DomainP-type_ATPase_IV

ATP8B4 ATP8A1 ATP8A2

2.02e-0514733IPR006539
DomainPhoLip_ATPase_C

ATP8B4 ATP8A1 ATP8A2

2.02e-0514733PF16212
DomainPhoLip_ATPase_N

ATP8B4 ATP8A1 ATP8A2

2.02e-0514733PF16209
Domain-

ATP8B4 ATP8A1 ATP8A2

2.62e-04327333.40.1110.10
Domain-

ATP8B4 ATP8A1 ATP8A2

2.62e-04327332.70.150.10
DomainEGF

ATRN MALRD1 CELSR2 NRXN1 UMODL1 ZNF578

3.14e-04235736SM00181
DomainATPase_P-typ_cyto_domN

ATP8B4 ATP8A1 ATP8A2

3.43e-0435733IPR023299
DomainP_typ_ATPase

ATP8B4 ATP8A1 ATP8A2

3.73e-0436733IPR001757
DomainATPase_P-typ_P_site

ATP8B4 ATP8A1 ATP8A2

3.73e-0436733IPR018303
DomainATPASE_E1_E2

ATP8B4 ATP8A1 ATP8A2

3.73e-0436733PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B4 ATP8A1 ATP8A2

4.05e-0437733IPR008250
DomainE1-E2_ATPase

ATP8B4 ATP8A1 ATP8A2

4.05e-0437733PF00122
DomainGPCR_3_mtglu_rcpt

GRM4 GRM7

4.16e-048732IPR000162
DomainNCD3G

GRM4 GRM7

1.14e-0313732PF07562
DomainGPCR_3_9-Cys_dom

GRM4 GRM7

1.14e-0313732IPR011500
DomainGPCR_3_CS

GRM4 GRM7

1.33e-0314732IPR017979
DomainEGF

ATRN MALRD1 CELSR2 NRXN1

1.50e-03126734PF00008
DomainActin_CS

ACTL6B ACTL6A

1.75e-0316732IPR004001
DomainACTINS_2

ACTL6B ACTL6A

1.97e-0317732PS00432
Domain-

ATP8B4 ATP8A1 ATP8A2

2.01e-03647333.40.50.1000
DomainEGF_3

ATRN MALRD1 CELSR2 NRXN1 UMODL1

2.27e-03235735PS50026
DomainEGF-like_dom

ATRN MALRD1 CELSR2 NRXN1 UMODL1

2.91e-03249735IPR000742
DomainGPCR_3

GRM4 GRM7

3.02e-0321732IPR000337
DomainEGF_1

ATRN MALRD1 CELSR2 NRXN1 UMODL1

3.22e-03255735PS00022
Domain7tm_3

GRM4 GRM7

3.31e-0322732PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM4 GRM7

3.31e-0322732PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM4 GRM7

3.31e-0322732PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM4 GRM7

3.31e-0322732PS00979
DomainG_PROTEIN_RECEP_F3_4

GRM4 GRM7

3.31e-0322732PS50259
DomainGPCR_3_C

GRM4 GRM7

3.31e-0322732IPR017978
DomainEGF-like_CS

ATRN MALRD1 CELSR2 NRXN1 UMODL1

3.56e-03261735IPR013032
DomainHAD-like_dom

ATP8B4 ATP8A1 ATP8A2

3.66e-0379733IPR023214
DomainEGF_2

ATRN MALRD1 CELSR2 NRXN1 UMODL1

3.79e-03265735PS01186
DomainJmjC

KDM6B UTY

3.93e-0324732PF02373
DomainTNFR

CELSR2 LTBR

4.61e-0326732SM00208
DomainEGF_LAM_2

ATRN CELSR2

6.11e-0330732PS50027
DomainEGF_LAM_1

ATRN CELSR2

6.11e-0330732PS01248
Domain-

CELSR2 NRXN1 NBEAL1

6.13e-03957332.60.120.200
DomainActin

ACTL6B ACTL6A

6.51e-0331732IPR004000
DomainActin

ACTL6B ACTL6A

6.51e-0331732PF00022
DomainACTIN

ACTL6B ACTL6A

6.51e-0331732SM00268
DomainJMJC

KDM6B UTY

6.93e-0332732PS51184
DomainJmjC_dom

KDM6B UTY

6.93e-0332732IPR003347
DomainASX_HYDROXYL

CELSR2 NRXN1 UMODL1

7.06e-03100733PS00010
DomainJmjC

KDM6B UTY

7.36e-0333732SM00558
DomainTNFR/NGFR_Cys_rich_reg

CELSR2 LTBR

7.36e-0333732IPR001368
DomainGPS

CELSR2 PKD1L3

7.80e-0334732SM00303
Pubmed

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.

ATP8B4 ATP8A1 ATP8A2

3.35e-07775320947505
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP8B4 ATP8A1 ATP8A2

2.71e-061375311015572
Pubmed

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.

ACTL6B ACTL6A

4.59e-06275219561591
Pubmed

In with the TRP channels: intracellular functions for TRPM1 and TRPM2.

TRPM2 TRPM1

4.59e-06275219887679
Pubmed

Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.

GRM4 GRM7

4.59e-06275219351574
Pubmed

Unknown genes, Cebelin and Cebelin-like, predominantly expressed in mouse brain.

FAM163B FAM163A

4.59e-06275230294689
Pubmed

Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.

ACTL6B ACTL6A

4.59e-06275210380635
Pubmed

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.

NRXN1 GRM4 GABRA5

6.41e-061775327779093
Pubmed

Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.

ACTL6B ACTL6A NR3C1

1.07e-05207539128241
Pubmed

Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.

ACTL6B ACTL6A

1.37e-05375212437990
Pubmed

Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.

GRM4 GRM7

1.37e-05375233068816
Pubmed

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.

ACTL6B ACTL6A

1.37e-05375227226355
Pubmed

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.

NRXN1 BSN

1.37e-05375234320240
Pubmed

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.

GRM4 GRM7

1.37e-0537529473604
Pubmed

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.

ATP8A1 ATP8A2

1.37e-05375225595798
Pubmed

Actin-related proteins.

ACTL6B ACTL6A

2.75e-05475210611965
Pubmed

GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation.

NRXN1 BSN

2.75e-05475222457515
Pubmed

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.

TRPM1 BSN

2.75e-05475219966281
Pubmed

Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.

TRPM2 PKD1L3

2.75e-05475227196058
Pubmed

Distribution of group-III metabotropic glutamate receptors in the retina.

GRM4 GRM7

2.75e-05475217311335
Pubmed

Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.

NRXN1 GRM7 GABRA5

4.15e-053175319736351
Pubmed

Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

TRPM2 TRPM1

4.57e-05575216857711
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM2 TRPM1 PKD1L3

5.02e-053375319834762
Pubmed

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.

ATRN MYO5A ATP8A2 TRPM1

6.69e-0510075426073538
Pubmed

Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.

GRM4 GRM7

6.84e-05675216144832
Pubmed

Supervillin associates with androgen receptor and modulates its transcriptional activity.

SVIL NR3C1

6.84e-05675211792840
Pubmed

Isolation and regional assignment of human chromosome 12p cDNAs.

LTBR DDX11

6.84e-0567528530100
Pubmed

Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants.

MYO5A ATP8A2

6.84e-0567521150661
Pubmed

HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.

GRM4 GRM7 GABRA5

7.70e-053875325613138
Pubmed

CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.

ATP8B4 ATP8A1

9.57e-05775220961850
Pubmed

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.

GRM4 GRM7

9.57e-0577529920659
Pubmed

Mature B cells and mesenchymal stem cells control emergency myelopoiesis.

LTBR NR3C1

9.57e-05775236717247
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

FAM163B BMPR2 ATP8A1 MYO5A BSN GRM7

1.07e-0434775617114649
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM2 TRPM1 PKD1L3

1.20e-044475319322198
Pubmed

Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.

NRXN1 BSN

1.64e-04975221356198
Pubmed

Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

SLC25A28 CDH10

1.64e-04975223279374
Pubmed

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.

KDM6B UTY

1.64e-04975222949634
Pubmed

Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.

GRM4 GRM7 GABRA5

1.97e-045275319328558
Pubmed

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

GRM4 GRM7

2.04e-04107529069281
Pubmed

The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.

GRM4 GRM7

2.04e-041075217156446
Pubmed

The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.

ATP8A1 ATP8A2

2.04e-041075215919184
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ILF2 CELSR2 NRXN1 MYO5A SVIL BSN GRM4 CDH10 RASAL1

2.26e-0496375928671696
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

BMPR2 NRXN1 ATP8A2 AQP4 ADCY3 GABRA5

2.46e-0440575638187761
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM2 TRPM1

2.99e-041275219850157
Pubmed

Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.

ACTL6B ACTL6A

3.52e-041375211726552
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

ACTL6B ACTL6A KDM6B

3.82e-046575326655900
Pubmed

Pigmentation-related genes and their implication in malignant melanoma susceptibility.

ATRN MYO5A

4.11e-041475219320733
Pubmed

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.

ACTL6B ACTL6A

4.11e-041475236289231
Pubmed

The biochemical anatomy of cortical inhibitory synapses.

NRXN1 GABRA5

4.11e-041475222768092
Pubmed

A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.

ACTL6B ACTL6A

4.11e-041475230510198
Pubmed

Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

ACTL6B ACTL6A

4.73e-041575223785148
Pubmed

An essential switch in subunit composition of a chromatin remodeling complex during neural development.

ACTL6B ACTL6A

4.73e-041575217640523
Pubmed

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.

ACTL6B ACTL6A

4.73e-041575211263494
Pubmed

Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.

ACTL6B ACTL6A

4.73e-041575211175787
Pubmed

PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.

ACTL6B ACTL6A

4.73e-041575215985610
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

NRXN1 NR3C1 GRM4 GRM7 GABRA5

4.87e-0430075519086053
Pubmed

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

MYO5A C3orf38 ATP8A2

5.16e-047275325917818
Pubmed

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

KDM6B UTY

5.40e-041675235212626
Pubmed

Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells.

KDM6B ADCY3

6.11e-041775232986815
Pubmed

Identification of a polymorphic, neuron-specific chromatin remodeling complex.

ACTL6B ACTL6A

6.11e-041775212368262
Pubmed

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.

ACTL6B ACTL6A

6.11e-041775211078522
Pubmed

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.

ACSL3 AIFM2

6.11e-041775214741744
Pubmed

BAF complexes facilitate decatenation of DNA by topoisomerase IIα.

ACTL6B ACTL6A

6.87e-041875223698369
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

GRM4 GRM7 GABRA5

7.28e-048175322723691
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ACSL3 CELSR2 NRXN1 MYO5A ACTL6B BSN AQP4 RASAL1 GABRA5

7.59e-04113975936417873
Pubmed

Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.

ACTL6B ACTL6A

7.66e-041975216932743
Pubmed

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

ACTL6B ACTL6A

7.66e-041975225066234
Pubmed

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.

ACTL6B ACTL6A

7.66e-041975212110891
Pubmed

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.

ACTL6B ACTL6A

7.66e-041975218809673
Pubmed

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

MYO5A FARP2

9.38e-042175225340873
Pubmed

Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.

UMODL1 ADCY3

9.38e-042175220692344
Pubmed

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

ATP8A1 MYO5A BSN CBR1

9.73e-0420275433601422
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ILF2 ATP8A1 MYO5A SVIL DPYSL5 ACTL6B BSN CBR1 AQP4 RASAL1

9.81e-041431751037142655
Pubmed

BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex.

ACTL6B ACTL6A

1.13e-032375233602870
Pubmed

Diversity and specialization of mammalian SWI/SNF complexes.

ACTL6B ACTL6A

1.13e-03237528804307
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRM4 GRM7

1.23e-032475235746896
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM2 TRPM1

1.23e-032475233884443
Pubmed

Genetic determinants influencing human serum metabolome among African Americans.

THEM4 UGT1A6

1.23e-032475224625756
Pubmed

SWI/SNF chromatin remodeling and cancer.

ACTL6B ACTL6A

1.23e-032475211790558
Pubmed

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

ACTL6B ACTL6A

1.23e-032475210078207
Pubmed

The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.

ACTL6B ACTL6A

1.23e-032475212215535
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ATRN BMPR2 THEM4 MYO5A NUP210 TRPM2 DPYSL5 LTBR ADCY3 FARP2

1.32e-031489751028611215
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM2 TRPM1

1.33e-032575216382100
Pubmed

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

ACTL6B ACTL6A

1.44e-032675210778858
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ATRN NRXN1 ADCY3

1.54e-031057539628581
Pubmed

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

ACTL6B ACTL6A

1.56e-032775229374058
Pubmed

Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.

ACTL6A CBR1

1.56e-032775221320693
Pubmed

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

ACTL6B RASGRP2

1.56e-032775223359859
Pubmed

An introduction to TRP channels.

TRPM2 TRPM1

1.56e-032775216460286
Pubmed

mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.

ACTL6B ACTL6A

1.67e-032875227611684
Pubmed

REST repression of neuronal genes requires components of the hSWI.SNF complex.

ACTL6B ACTL6A

1.67e-032875212192000
Pubmed

The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.

RASAL1 GABRA5

1.79e-032975218077674
Cytoband2p23.3

DPYSL5 MFSD2B ADCY3

1.94e-04687532p23.3
GeneFamilyATPase phospholipid transporting

ATP8B4 ATP8A1 ATP8A2

9.96e-06155231210
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM4 GRM7

2.25e-048522281
GeneFamilyPHD finger proteins|Lysine demethylases

KDM6B UTY

2.15e-0324522485
GeneFamilyTransient receptor potential cation channels

TRPM2 TRPM1

2.92e-0328522249
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

AIFM2 BMPR2 LNX2 ATP8A1 WASHC4 CELSR2 NUP210 DPYSL5 EXOSC1 TRPM1 ACTL6A NR3C1 PHYHIPL RASAL1

4.60e-069837214Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWA5B2 NRXN1 ATP8A2 SLC2A7 BSN PHYHIPL

2.92e-071597567747cef94c55144fddcd024a7495318357f1351b
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWA5B2 NRXN1 ATP8A2 ACTL6B BSN PHYHIPL

7.79e-07188756c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

MALRD1 ATP8A1 CELSR2 NBEAL1 CACHD1 AQP4

8.54e-07191756d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

9.08e-07193756a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

9.64e-07195756148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

9.64e-07195756ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWA5B2 FAM163B ATP8A2 BSN GRM7 GABRA5

1.12e-062007562f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

1.12e-06200756179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWA5B2 FAM163B ATP8A2 BSN GRM7 GABRA5

1.12e-06200756bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

1.12e-06200756ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWA5B2 FAM163B ATP8A2 BSN GRM7 GABRA5

1.12e-06200756dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 NFAM1 MFSD1

1.12e-0620075646f9c28b24e39acdf0481a02b6eb86ecdd83c504
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B GABRA5

7.77e-06161755bb9cb42882aaa4a1ecf9b480c0e7ac302f2c0d5d
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM163B ATP8B4 ATP8A1 NR3C1 BSN

1.10e-051737555d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM163B ATP8B4 ATP8A1 NR3C1 BSN

1.13e-051747559eab43885496b8586f8ec5b4bcb1fd5b209218e5
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP8B4 MYO5A UGT1A6 CD48 NFAM1

1.26e-05178755aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

LNX2 MALRD1 ATP8A1 CELSR2 AQP4

1.30e-05179755cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellwk_15-18-Epithelial-PNS-KCNIP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B BSN

1.30e-05179755e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MALRD1 TRPM1 AQP4 AWAT2

1.30e-0585754786258a945fd9c67d473fc66d4b6c147cb9dfd86
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MALRD1 TRPM1 AQP4 AWAT2

1.30e-05857547bb9cd33f2131ac0d3aa6b13b0ffa2ee8cbff8c6
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MALRD1 TRPM1 AQP4 AWAT2

1.30e-0585754d004ba0fbef8b4d07b5b26e6b935c793d52431e0
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

VWA5B2 NRXN1 ATP8A2 BSN PHYHIPL

1.41e-0518275557bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.52e-05185755ab5704b96f1d368911308797d10c7c52766ab134
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATRN ATP8B4 MYO5A TRPM2 CR1

1.52e-051857558207f9eff113eed429e961748c6b17d672a13b33
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWA5B2 NRXN1 ATP8A2 BSN PHYHIPL

1.56e-05186755b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellwk_15-18-Epithelial-PNS-PCP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B PHYHIPL

1.69e-0518975522c927d2691b867fbdee1fbee042a6d3f7eadd7d
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.69e-051897552586f4088721c5debec86c2b211b739fd33713eb
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA5B2 FAM163B NRXN1 ACTL6B PKD1L3

1.73e-0519075540d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA5B2 FAM163B NRXN1 ACTL6B PKD1L3

1.73e-05190755f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.73e-05190755f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellControl-Myeloid-Transitioning_MDM|Control / group, cell type (main and fine annotations)

ACSL3 ATP8B4 TRPM2 NFAM1 MFSD1

1.73e-05190755d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA5B2 FAM163B NRXN1 ACTL6B PKD1L3

1.73e-05190755a9a705455019e28d655636de73b07540798f82e6
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.77e-0519175524d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LNX2 MALRD1 ATP8A1 CELSR2 AQP4

1.82e-0519275529f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.87e-0519375531c0978ba78c9516d498aec0798902e57555e557
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.87e-0519375564d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCellwk_15-18-Epithelial-PNS|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B PHYHIPL

1.87e-05193755ca65f8f93058ad50d89e69e06c10deeb46dbfc87
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.91e-05194755f09675cd472200363c458952f00d2e41990800ee
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|367C / Donor, Lineage, Cell class and subclass (all cells)

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.91e-05194755e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 NFAM1 MFSD1

1.91e-05194755800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B4 MYO5A TRPM2 PKD1L3 MFSD1

1.91e-05194755c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.96e-05195755c172c5599379c29123340621a36bfb1fc90c2115
ToppCell11.5-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

VWA5B2 NRXN1 RHBDL1 ACTL6B PHYHIPL

1.96e-05195755eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP8B4 MYO5A TRPM2 CR1 MFSD1

1.96e-05195755312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCellfacs-Brain_Non-Myeloid-Cortex|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSL3 ATRN NRXN1 PHYHIPL AQP4

2.01e-05196755256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAM163A CELSR2 NRXN1 BSN PHYHIPL

2.01e-051967554bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

ATP8B4 UMODL1 TRPM2 NFAM1 UTY

2.01e-0519675516b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.01e-05196755a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.01e-051967557026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 MYO5A TRPM2 NFAM1 MFSD1

2.06e-0519775510190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellwk_08-11-Epithelial-PNS|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B PHYHIPL

2.06e-05197755ce3f9feb6935f0e9daf13673b0a0d6e92817e187
ToppCellnucseq-Immune-Immune_Myeloid-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.06e-051977556f41c8f815851968849428ec92c16745bd01a3fb
ToppCellnucseq-Immune-Immune_Myeloid-IM-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.06e-05197755304044ace926943b8eb588f686ecbe5d1689a809
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.11e-051987556a4161680b46b2c12353a693c403b5a4bb3da03f
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.11e-051987550b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 MYO5A TRPM2 NFAM1 MFSD1

2.16e-05199755f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 MYO5A TRPM2 NFAM1 MFSD1

2.16e-051997555ceeed92f831d068ff4bb3994f420002338330e7
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 TRPM2 CR1 NFAM1 MFSD1

2.21e-05200755f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 MYO5A TRPM2 CR1 MFSD1

2.21e-0520075578d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A TRPM2 CR1 NFAM1 MFSD1

2.21e-05200755c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8B4 SVIL TRPM2 NFAM1

1.03e-041447541efa434e577d1f87e02df01667782f414d63bd60
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8B4 SVIL TRPM2 NFAM1

1.03e-04144754c0c5f254a960ba5e5f1354599d54e77360e6c2ac
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Lymphocytic-B_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH8 FAM163A CD48 RASAL1

1.17e-04149754a6e192bf9bcf3b219e618c465bc451f7c86f49f1
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LNX2 PGPEP1 ADCY3 GABRA5

1.33e-0415475416fdafb5c64d2db321554f87129a962d113f1668
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 CD48 KDM6B NFAM1

1.50e-04159754cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2|TCGA-Mesothelium / Sample_Type by Project: Shred V9

ATP8A1 CACHD1 PKD1L3 ADCY3

1.54e-04160754d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8B4 THEM4 TRPM2 NFAM1

1.54e-041607545d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 ACTL6B GRM4 RFX3

1.73e-041657544b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 ATP8A2 CD48 DDX11

1.73e-04165754475905d608fac628960188ae4a18010b8097417e
ToppCellfacs-Aorta-Heart-24m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR46 CD48 GEMIN6 NFAM1

1.81e-04167754b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVIL TRPM2 KDM6B NFAM1

1.90e-04169754a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

NRXN1 DPYSL5 ACTL6B BSN

1.90e-041697549c4e83fe8225d16173a103bf5a57b17d623be923
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWA5B2 FAM163A NRXN1 CDH10

1.90e-0416975496a2aec9acf8a6f966973c035e5ade456cf47772
ToppCellfacs-GAT-Fat-18m-Myeloid-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 CD48 KDM6B NFAM1

1.90e-041697547a7416fcbffcf57d19b477d9da091e04e3499524
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SVIL TRPM2 KDM6B NFAM1

1.90e-04169754e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCellfacs-GAT-Fat-18m-Myeloid|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 CD48 KDM6B NFAM1

1.90e-041697540e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWA5B2 NRXN1 ATP8A2 CDH10

1.90e-04169754b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellfacs-GAT-Fat-18m-Myeloid-myeloid_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 CD48 KDM6B NFAM1

1.90e-041697549bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CELSR2 PLPP2 UGT1A6 RHBDL1

1.90e-04169754d59c8cd0719ed0947d42da9e7e5da72ff58ecc0d
ToppCellTCGA-Brain|World / Sample_Type by Project: Shred V9

NRXN1 DPYSL5 AQP4 CDH10

1.94e-04170754f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCelldroplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSL3 PLPP2 CD48 NFAM1

1.94e-04170754545c755b057871b7a22221a049a63a61713dad1d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NRXN1 RHBDL1 ACTL6B GRM4

1.94e-0417075498d13dbd76a826e47d55553f9d11f71c043b573e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAM163A MUC19 CACHD1 RASAL1

1.98e-04171754fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 FAM163A ACTL6B AQP4

2.07e-0417375430fa8c14c8a1f546f380132c0c28a61e6a2f9fc4
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MALRD1 ATP8A1 CELSR2 AQP4

2.07e-04173754b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ATP8A1 ATP8A2 NR3C1 DDX11

2.21e-04176754437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN ATP8B4 SVIL NFAM1

2.26e-04177754065bebd22031f143e90a407f952b444a3f8818c7
ToppCellfacs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 NUP210 CD48 NFAM1

2.26e-041777547bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FAM163B FAM163A ATP8A1 NRXN1

2.26e-0417775415a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCellwk_15-18-Epithelial-PNS-COL20A1+_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 PHYHIPL GABRA5

2.26e-04177754b8cc6a7abf83a9844a5293b6cc4b19135b51fd53
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FAM163A NRXN1 DPYSL5 ACTL6B

2.26e-041777548c78f7de091f16e86e326a73c9f1429e0232821f
ToppCellfacs-Marrow-Granulocytes-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN ATP8B4 SVIL NFAM1

2.26e-04177754eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCellfacs-Diaphragm-Limb_Muscle-18m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 NUP210 NFAM1 RASGRP2

2.31e-0417875440bd605b801d9ae76cffc8f62836092fc2b06812
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAM163B LNX2 OR1Q1 CDH10

2.31e-04178754a48739a588f361b4bc69405d7e256c11f61cf43c
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 NRXN1 TRPM2 ACTL6B

2.31e-0417875430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN1 ATP8A2 PGPEP1 GRM7

2.46e-04181754c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellfacs-Aorta-Heart-3m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B4 NUP210 CD48 NFAM1

2.52e-04182754df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCellwk_15-18-Epithelial-PNS-SST+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NRXN1 DPYSL5 ACTL6B PHYHIPL

2.52e-04182754a7e77aaaddabf78c7784f72b3431703fc5ee4a8c
ToppCellwk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

VWA5B2 NRXN1 ACTL6B CDH10

2.57e-041837548820cfed27b292bc0bc9cde4005219ed41900552
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ATP8B4 CD48 NFAM1 RASGRP2

2.57e-04183754aed12b743334f3813db0c70d4fe7df90e0673f54
Drugglutamate

TRPM2 IREB2 PGPEP1 ACTL6B TRPM1 ACTL6A NR3C1 BSN PKD1L3 GRM4 GRM7 AQP4 ADCY3 GABRA5

2.25e-069627414CID000000611
Drugbaclofen

DPYSL5 BSN PKD1L3 GRM4 GRM7 ADCY3 GABRA5

2.93e-06191747CID000002284
DrugDE gel

ACTL6B ACTL6A BSN GRM4 GRM7 GABRA5

7.20e-06143746CID000008146
DrugFm 4-64

MYO5A RHBDL1 ACTL6B ACTL6A BSN

1.12e-0590745CID002733635
Diseaseneural cell adhesion molecule l1-like protein measurement

DCBLD2 DDX11

6.01e-055732EFO_0020595
Diseasesevere acute respiratory syndrome, COVID-19

MALRD1 NRXN1 ATP8A2 NUP210 TRPM2 TRPM1 GRM7

1.20e-04447737EFO_0000694, MONDO_0100096
Diseasealcohol use disorder (implicated_via_orthology)

RHBDL1 ACTL6B ACTL6A KDM6B UTY

1.25e-04195735DOID:1574 (implicated_via_orthology)
DiseaseLDL cholesterol change measurement

CELSR2 PKD1L3

1.26e-047732EFO_0007804
DiseaseBipolar Disorder

NRXN1 TRPM2 NR3C1 GRM4 GRM7 ADCY3 GABRA5

1.79e-04477737C0005586
Diseasegrip strength measurement

C3orf38 PGPEP1 PKD1L3 GRM7 ADCY3 DDX11

2.33e-04350736EFO_0006941
Diseasebiliverdin measurement

UGT1A6 GRM4

3.92e-0412732EFO_0021033
DiseaseAutistic Disorder

NRXN1 AQP4 CDH10 GABRA5 FARP2

4.79e-04261735C0004352
Diseasecigarettes per day measurement

FAM163B FAM163A IREB2 GRM4 GRM7 ADCY3

7.61e-04438736EFO_0006525
Diseasenicotine dependence

FAM163B IREB2 CDH10

9.67e-0478733EFO_0003768
Diseaseperipheral neuropathy, response to docetaxel trihydrate

ATP8A2 TRPM2

1.00e-0319732EFO_0003100, GO_1902519
DiseaseMalaria

LTBR CR1

1.11e-0320732C0024530
Diseasetestosterone measurement

NRXN1 MYO5A C3orf38 UGT1A6 TRPM2 TSC22D2 NR3C1 KDM6B SPIN3 FARP2

1.14e-0312757310EFO_0004908
DiseaseAutism Spectrum Disorders

NRXN1 CDH10 GABRA5

1.24e-0385733C1510586
Diseaseobsolete Mendelian syndromes with cleft lip/palate

SVIL GRM7

1.48e-0323732MONDO_0015335
Diseaseuveitis (biomarker_via_orthology)

NR3C1 AQP4

1.75e-0325732DOID:13141 (biomarker_via_orthology)
Diseasesusceptibility to pneumonia measurement

AIFM2 MALRD1 ADCY3

1.81e-0397733EFO_0008410
Diseasexanthurenate measurement

UGT1A6 GRM7

2.35e-0329732EFO_0010551

Protein segments in the cluster

PeptideGeneStartEntry
IGRIMVSNVTSTGFH

UMODL1

706

Q5DID0
VVGGLGVTMVHGNLT

AQP4

141

P55087
ALGTGIAGISTSVMT

nan

406

Q9N2K0
GNTMLGVGHVVTTSI

ACTL6B

316

O94805
GVGHVVTTSIGMCDI

ACTL6B

321

O94805
VGVIGASGSSVSIMV

GRM4

151

Q14833
GLSGNTMLGVSHVVT

ACTL6A

316

O96019
STQLSSGHTVAVMGI

CACHD1

796

Q5VU97
SMIKSAHIGVGISGQ

ATP8B4

821

Q8TF62
GHVMLSVEGTGLQAS

CELSR2

1671

Q9HCU4
VSMIQTAHVGVGISG

ATP8A1

806

Q9Y2Q0
VGMIQTAHVGVGISG

ATP8A2

826

Q9NTI2
MAVSGSRDGTVIIHT

NBEAL1

2506

Q6ZS30
MQVVTQDGTGALHTT

RASAL1

636

O95294
VVGTDSHITMVNGLG

IREB2

276

P48200
TVTVKGVMTTGSDIG

NUP210

496

Q8TEM1
NTLMAVVGGLSHSSI

RASGRP2

241

Q7LDG7
GSGVVNIVMTITSAV

SLC2A7

326

Q6PXP3
LHTAVIVSGTMLVFG

ATRN

556

O75882
VTSTGNMLSHVGHTI

KDM6B

1356

O15054
IVAVNGLSTVGMSHS

LNX2

651

Q8N448
HTVVVQMGEGTAGTV

BSN

1861

Q9UPA5
MGGFVHSTVQTILTV

OR4Q2

151

P0C623
AGVTMTSIQSAGVLV

MUC19

3041

Q7Z5P9
SPQLVVHVGVSGMAT

PGPEP1

66

Q9NXJ5
VHVGVSGMATTVTLE

PGPEP1

71

Q9NXJ5
TVTTHMVAGAVAGIL

SLC25A28

71

Q96A46
AGHTTLGITLMIGGI

MFSD1

206

Q9H3U5
GTLMGATVHGLIVSG

MFSD2B

191

A6NFX1
HLMGQTVGTENISTS

GABRA5

226

P31644
MSAISVHGVSTSGGQ

NR3C1

316

P04150
LGVVVAHSESGIQMV

EXOSC1

151

Q9Y3B2
GIGHAMVTISVDGIL

NRXN1

381

Q9ULB1
TITHGLMAGVTITAT

PLPP2

51

O43688
TITGMHSVEVSGSQL

DDX11

401

Q96FC9
HIVVISSVMGLQGVI

RDH8

136

Q9NYR8
THMNGATVGSLQVLI

MALRD1

1181

Q5VYJ5
LTHKGTGNMVIVVIG

AWAT2

171

Q6E213
VNGMVHVITDIQVGS

CR1

561

P17927
VNGMVHVITDIQVGS

CR1

1011

P17927
MGGLSGTTTVNITLT

CDH10

246

Q9Y6N8
MTAGTVVITGGILAT

FAM163B

1

P0C2L3
LVMVGVAGTVHRGNT

C3orf38

231

Q5JPI3
GTMTTGHNVADLVVI

ILF2

111

Q12905
VVTVTMNGVAGRNHS

BMPR2

801

Q13873
HTVLHGDTVTGVTIM

MTFMT

161

Q96DP5
KTGVDMRVGVHTGTV

ADCY3

406

O60266
MSSGIHVALVTGGNK

CBR1

1

P16152
VGVIGASGSSVSIMV

GRM7

151

Q14831
MTAGTVVITGGILAT

FAM163A

1

Q96GL9
ITGIITTGSTMVEHN

DCBLD2

361

Q96PD2
LAVSHMGVLVFQGTT

FARP2

246

O94887
SVTGIMGHAVQTVET

GEMIN6

56

Q8WXD5
IQGHLVHMTVVSGSN

CD48

26

P09326
TKAALVGGTTMIIGH

DPYSL5

86

Q9BPU6
TSIGGIIHVDQIVQM

PHKA2

1156

P46019
TLMIHTEGAVVISGA

OR1Q1

196

Q15612
SVGTVAEITGHQLMS

PHYHIPL

341

Q96FC7
LTHVGHTILGMNTVQ

UTY

1066

O14607
VGGMHETVLTVTGKS

SVIL

1281

O95425
TGGSVVVVVASMQGA

TSC22D2

221

O75157
MGSQVSVESGALHVV

AIFM2

1

Q9BRQ8
VVSSHSMVGTGGIQM

RFX3

106

P48380
GGQSVTHTGLPIMAS

NFAM1

41

Q8NET5
SAVTVVGLLMGISHQ

PKD1L3

1626

Q7Z443
AHLAGAVVGVSMGLT

RHBDL1

376

O75783
GVMISHSNIIAGITG

ACSL3

296

O95573
LTVPSSVVMGDNGHT

C11orf40

76

Q8WZ69
STGQGNTEVIHTGML

ZNF578

76

Q96N58
IHGGAIATMIDATVG

THEM4

151

Q5T1C6
TGAGHGSVSVTMIKR

SPIN3

16

Q5JUX0
ITGGSHTGVMKQVGE

TRPM2

206

O94759
VLGVGHTGGITSMLV

WDR46

461

O15213
NGIHVTGGSMTITGN

LTBR

346

P36941
GHASSVSSLVIVSGM

TRPM1

1571

Q7Z4N2
TGIIAAAGTMTVTLH

VWA5B2

121

Q8N398
SIRTHGTGIMNTTVN

WASHC4

826

Q2M389
SGEHGIVVFSLGSMV

UGT1A6

296

P19224
VSGMLEHETIQGVSG

MYO5A

1626

Q9Y4I1