Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopolyphosphatase activity	NUDT11 NUDT10	8.83e-05	5	60	2	GO:0000298
GeneOntologyMolecularFunction	bis(5'-adenosyl)-hexaphosphatase activity	NUDT11 NUDT10	8.83e-05	5	60	2	GO:0034431
GeneOntologyMolecularFunction	diphosphoinositol-polyphosphate diphosphatase activity	NUDT11 NUDT10	8.83e-05	5	60	2	GO:0008486
GeneOntologyMolecularFunction	bis(5'-adenosyl)-pentaphosphatase activity	NUDT11 NUDT10	1.32e-04	6	60	2	GO:0034432
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	OPRD1 OPRL1	1.85e-04	7	60	2	GO:0004985
GeneOntologyBiologicalProcess	regulation of locomotor rhythm	ZFHX3 OPRL1	4.81e-05	4	59	2	GO:1904059
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) metabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901910
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901911
GeneOntologyBiologicalProcess	diadenosine pentaphosphate catabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901907
GeneOntologyBiologicalProcess	diadenosine pentaphosphate metabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901906
GeneOntologyBiologicalProcess	diadenosine hexaphosphate catabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901909
GeneOntologyBiologicalProcess	diadenosine hexaphosphate metabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:1901908
GeneOntologyBiologicalProcess	diphosphoinositol polyphosphate metabolic process	NUDT11 NUDT10	8.00e-05	5	59	2	GO:0071543
GeneOntologyBiologicalProcess	diadenosine polyphosphate catabolic process	NUDT11 NUDT10	1.20e-04	6	59	2	GO:0015961
GeneOntologyBiologicalProcess	defense response to protozoan	GBP6 GBP4 ENPP1	1.89e-04	39	59	3	GO:0042832
GeneOntologyBiologicalProcess	cellular response to interferon-beta	GBP6 GBP4 PYHIN1	2.19e-04	41	59	3	GO:0035458
GeneOntologyBiologicalProcess	response to protozoan	GBP6 GBP4 ENPP1	2.36e-04	42	59	3	GO:0001562
GeneOntologyBiologicalProcess	diadenosine polyphosphate metabolic process	NUDT11 NUDT10	2.86e-04	9	59	2	GO:0015959
GeneOntologyBiologicalProcess	response to interferon-beta	GBP6 GBP4 PYHIN1	3.51e-04	48	59	3	GO:0035456
GeneOntologyCellularComponent	host cell part	GBP6 GBP4	1.21e-04	6	60	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP6 GBP4	1.21e-04	6	60	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP6 GBP4	1.21e-04	6	60	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP6 GBP4	1.21e-04	6	60	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP6 GBP4	1.21e-04	6	60	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP6 GBP4	1.21e-04	6	60	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP6 GBP4	1.21e-04	6	60	2	GO:0030430
GeneOntologyCellularComponent	actin filament	CORO1A ACTL8 MYO9B GJB6	8.22e-04	146	60	4	GO:0005884
GeneOntologyCellularComponent	host cellular component	GBP6 GBP4	8.30e-04	15	60	2	GO:0018995
GeneOntologyCellularComponent	actin cytoskeleton	CORO1A ACTL8 BAIAP2L1 MYO9B GJB6 OPHN1 AFAP1L1	1.27e-03	576	60	7	GO:0015629
Domain	ZINC_FINGER_C2H2_2	DUSP12 ZNF141 ZNF286B RBM5 ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.32e-05	775	55	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF141 TUT4 ZNF286B RBM5 ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.35e-05	777	55	11	PS00028
Domain	Znf_C2H2	DUSP12 ZNF141 ZNF286B RBM5 ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.88e-05	805	55	11	IPR007087
Domain	Opioid_rcpt	OPRD1 OPRL1	5.09e-05	4	55	2	IPR001418
Domain	Znf_C2H2-like	ZNF141 ZNF286B RBM5 ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	9.57e-05	796	55	10	IPR015880
Domain	ZnF_C2H2	ZNF141 ZNF286B RBM5 ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.08e-04	808	55	10	SM00355
Domain	-	ZNF141 ZNF286B ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.50e-04	679	55	9	3.30.160.60
Domain	zf-C2H2	ZNF141 ZNF286B ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.74e-04	693	55	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF141 ZNF286B ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.76e-04	694	55	9	IPR013087
Domain	GBP_C	GBP6 GBP4	3.77e-04	10	55	2	PF02841
Domain	G_GB1_RHD3_dom	GBP6 GBP4	4.60e-04	11	55	2	IPR030386
Domain	Guanylate-bd_C	GBP6 GBP4	4.60e-04	11	55	2	IPR003191
Domain	GBP	GBP6 GBP4	4.60e-04	11	55	2	PF02263
Domain	Guanylate-bd_N	GBP6 GBP4	4.60e-04	11	55	2	IPR015894
Domain	G_GB1_RHD3	GBP6 GBP4	4.60e-04	11	55	2	PS51715
Domain	NUDIX_hydrolase_CS	NUDT11 NUDT10	5.51e-04	12	55	2	IPR020084
Domain	I-BAR_dom	BAIAP2L1 OPHN1	6.50e-04	13	55	2	IPR013606
Domain	NUDIX_BOX	NUDT11 NUDT10	2.25e-03	24	55	2	PS00893
Domain	NUDIX	NUDT11 NUDT10	2.25e-03	24	55	2	PF00293
Domain	NUDIX	NUDT11 NUDT10	2.64e-03	26	55	2	PS51462
Domain	-	NUDT11 NUDT10	3.06e-03	28	55	2	3.90.79.10
Domain	NUDIX_hydrolase_dom-like	NUDT11 NUDT10	3.06e-03	28	55	2	IPR015797
Domain	NUDIX_hydrolase_dom	NUDT11 NUDT10	3.29e-03	29	55	2	IPR000086
Domain	KRAB	ZNF141 ZNF221 ZNF471 ZNF583 ZNF404	3.99e-03	358	55	5	PS50805
Domain	KRAB	ZNF141 ZNF221 ZNF471 ZNF583 ZNF404	3.99e-03	358	55	5	PF01352
Domain	KRAB	ZNF141 ZNF221 ZNF471 ZNF583 ZNF404	4.54e-03	369	55	5	SM00349
Domain	KRAB	ZNF141 ZNF221 ZNF471 ZNF583 ZNF404	4.59e-03	370	55	5	IPR001909
Domain	zf-C4	AR NR2F2	8.11e-03	46	55	2	PF00105
Domain	Znf_hrmn_rcpt	AR NR2F2	8.11e-03	46	55	2	IPR001628
Domain	NUCLEAR_REC_DBD_2	AR NR2F2	8.11e-03	46	55	2	PS51030
Domain	NUCLEAR_REC_DBD_1	AR NR2F2	8.11e-03	46	55	2	PS00031
Domain	ZnF_C4	AR NR2F2	8.11e-03	46	55	2	SM00399
Domain	-	AR NR2F2	8.46e-03	47	55	2	1.10.565.10
Domain	HOLI	AR NR2F2	8.81e-03	48	55	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	AR NR2F2	8.81e-03	48	55	2	IPR000536
Domain	Hormone_recep	AR NR2F2	8.81e-03	48	55	2	PF00104
Pathway	REACTOME_RAC1_GTPASE_CYCLE	BAIAP2L1 MYO9B DOCK7 CYFIP2 OPHN1	1.63e-04	175	42	5	MM15599
Pathway	REACTOME_RAC1_GTPASE_CYCLE	BAIAP2L1 MYO9B DOCK7 CYFIP2 OPHN1	2.06e-04	184	42	5	M41809
Pathway	PID_HNF3A_PATHWAY	PRDM15 AR NR2F2	2.99e-04	44	42	3	M285
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT10	3.84e-04	10	42	2	MM14709
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT10	3.84e-04	10	42	2	M27051
Pubmed	An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.	NUDT11 NUDT10	2.93e-06	2	60	2	12105228
Pubmed	AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells.	ZFHX3 AR	2.93e-06	2	60	2	34953044
Pubmed	Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.	NUDT11 NUDT10	2.93e-06	2	60	2	12689335
Pubmed	The chicken ovalbumin upstream promoter-transcription factor II negatively regulates the transactivation of androgen receptor in prostate cancer cells.	AR NR2F2	2.93e-06	2	60	2	23145053
Pubmed	Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor.	OPRD1 OPRL1	2.93e-06	2	60	2	9155012
Pubmed	Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases.	MANF LAMB2	2.93e-06	2	60	2	26940092
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	GBP6 GBP4 PYHIN1	6.35e-06	21	60	3	19158679
Pubmed	The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.	AR OPHN1	8.77e-06	3	60	2	12932438
Pubmed	Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.	NUDT11 NUDT10	8.77e-06	3	60	2	12121577
Pubmed	Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome.	MANF LAMB2	8.77e-06	3	60	2	31235574
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRD1 OPRL1	1.75e-05	4	60	2	8941707
Pubmed	Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.	NUDT11 NUDT10	1.75e-05	4	60	2	12370170
Pubmed	PC-1 works in conjunction with E3 ligase CHIP to regulate androgen receptor stability and activity.	ENPP1 AR	1.75e-05	4	60	2	27835608
Pubmed	Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.	OPRD1 OPRL1	1.75e-05	4	60	2	11430857
Pubmed	Hereditary Ataxia Overview	PNKP ZFHX3 TDP2 OPHN1	2.00e-05	92	60	4	20301317
Pubmed	Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.	NUDT11 NUDT10	2.92e-05	5	60	2	18264098
Pubmed	Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells.	MANF LAMB2	8.14e-05	8	60	2	11487633
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP6 GBP4	8.14e-05	8	60	2	16689661
Pubmed	Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.	CACNA1C ZFHX3	1.05e-04	9	60	2	21042317
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	CACNA1C NUDT11 SIGLEC6 NUDT10 ADAMTS8 LONRF3 OPHN1	1.58e-04	674	60	7	37196079
Pubmed	Multiple newly identified loci associated with prostate cancer susceptibility.	NUDT11 NUDT10	1.59e-04	11	60	2	18264097
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP6 GBP4	1.59e-04	11	60	2	18025219
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHISA9 CACNA1C TUT4 THOP1 APBB2 RBM5 ZFHX3 PRDM15 AR OPRL1	2.15e-04	1489	60	10	28611215
Pubmed	Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.	AR NR2F2	2.26e-04	13	60	2	9115274
Pubmed	A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.	BAIAP2L1 NR2F2	2.63e-04	14	60	2	22829776
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	OPRD1 OPRL1	2.63e-04	14	60	2	15086532
Pubmed	Validation of genome-wide prostate cancer associations in men of African descent.	NUDT11 NUDT10	3.03e-04	15	60	2	21071540
Pubmed	Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control.	MFAP2 NR2F2	3.91e-04	17	60	2	33706013
Pubmed	The expression pattern of nuclear receptors during cerebellar development.	AR NR2F2	3.91e-04	17	60	2	17205580
Pubmed	A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.	GBP6 GBP4	4.91e-04	19	60	2	21551061
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF221 ZNF404	5.45e-04	20	60	2	12743021
Pubmed	Nuclear receptors in Leydig cell gene expression and function.	AR NR2F2	6.61e-04	22	60	2	20375256
Pubmed	A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.	AR NR2F2	6.61e-04	22	60	2	23975195
Pubmed	GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.	AR NR2F2	7.88e-04	24	60	2	32497091
Pubmed	Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.	AR NR2F2	7.88e-04	24	60	2	28818950
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	MYO9B CSNK1G3 NUDT10 MANF RBM5 LAMB2 PRDM15 OPRL1	1.11e-03	1215	60	8	15146197
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	AR OPRD1 OPRL1	1.43e-03	128	60	3	19058789
Pubmed	The DNA sequence and biology of human chromosome 19.	PNKP THOP1 ZNF221 ZNF471	1.48e-03	284	60	4	15057824
Pubmed	Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions.	AR NR2F2	1.49e-03	33	60	2	36922518
Pubmed	CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.	NUDT11 NUDT10	1.58e-03	34	60	2	31201419
Cytoband	Ensembl 112 genes in cytogenetic band chrXq13	FAM236D FAM236A FAM236B FAM236C	7.16e-05	165	61	4	chrXq13
Cytoband	Ensembl 112 genes in cytogenetic band chrXq12	AR OPHN1	5.53e-04	26	61	2	chrXq12
Cytoband	Xq12	AR OPHN1	5.53e-04	26	61	2	Xq12
Cytoband	1p22.2	GBP6 GBP4	6.42e-04	28	61	2	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	MANF RBM5 LAMB2 USP19	8.44e-04	316	61	4	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PNKP SIGLEC6 ZNF221 ZNF471 ZNF583 ZNF541 ZNF404	1.01e-03	1192	61	7	chr19q13
Cytoband	Xq13.2	FAM236A FAM236B	1.38e-03	41	61	2	Xq13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF141 ZNF286B ZFHX3 ZNF221 ZNF471 PRDM15 ZNF583 ZNF541 ZNF404	1.35e-05	718	38	9	28
GeneFamily	Opioid receptors	OPRD1 OPRL1	2.57e-05	4	38	2	245
GeneFamily	Nudix hydrolase family	NUDT11 NUDT10	1.15e-03	24	38	2	667
GeneFamily	Nuclear hormone receptors	AR NR2F2	4.75e-03	49	38	2	71
GeneFamily	Ubiquitin specific peptidases	USP9Y USP19	6.17e-03	56	38	2	366
Coexpression	GSE28726_NAIVE_CD4_TCELL_VS_NAIVE_NKTCELL_DN	CORO1A MYO9B SIGLEC6 GCA USP19 CYFIP2	5.33e-06	200	58	6	M8311
Coexpression	GSE22886_IGM_MEMORY_BCELL_VS_BM_PLASMA_CELL_UP	PMS2P5 CORO1A RBM5 GCA TDP2 OPHN1	5.33e-06	200	58	6	M4456
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1C NUDT11 ACTL8 ZFHX3 NR2F2	2.49e-06	160	60	5	29c9b4770d0e73d59cffc7937b179484c76b6dcc
Drug	diadenosine 5',5''''-P1,P6-hexaphosphate	NUDT11 NUDT10	6.16e-06	2	57	2	ctd:C070070
Drug	adenosine 5'-tetraphosphate	NUDT11 NUDT10	6.16e-06	2	57	2	ctd:C017991
Drug	adenosine 5'-pentaphosphate	NUDT11 NUDT10	6.16e-06	2	57	2	ctd:C048567
Drug	Fluvastatin sodium salt [93957-55-2]; Up 200; 9.2uM; HL60; HT_HG-U133A	LAMB2 ZFHX3 ADAMTS8 NR2F2 CYFIP2 OPRL1	1.04e-05	199	57	6	3032_UP
Drug	NSC11411	OPRD1 OPRL1	1.84e-05	3	57	2	CID000408117
Drug	Ro 64-6198	OPRD1 OPRL1	1.84e-05	3	57	2	CID009844019
Drug	Adrenorphin	THOP1 OPRD1 OPRL1	3.29e-05	25	57	3	CID000122176
Drug	P(1),P(5)-di(adenosine-5'-)pentaphosphate	NUDT11 NUDT10	3.68e-05	4	57	2	ctd:C012275
Drug	Phe-Gly-Gly-Phe	OPRD1 OPRL1	3.68e-05	4	57	2	CID003327925
Drug	atipamezole	AR OPRD1 OPRL1	4.17e-05	27	57	3	CID000071310
Drug	AC1L2FKQ	OPRD1 OPRL1	6.13e-05	5	57	2	CID000020114
Drug	Tyr-tic-phe-phe-OH	OPRD1 OPRL1	6.13e-05	5	57	2	CID003035452
Drug	ICI 197067	OPRD1 OPRL1	6.13e-05	5	57	2	CID003081077
Drug	metkephamid acetate	OPRD1 OPRL1	6.13e-05	5	57	2	CID005464183
Drug	R-84760	OPRD1 OPRL1	6.13e-05	5	57	2	CID000133035
Drug	DALECK	OPRD1 OPRL1	6.13e-05	5	57	2	CID015942760
Drug	GPA 1657	OPRD1 OPRL1	6.13e-05	5	57	2	CID000030503
Drug	CTK3E6448	OPRD1 OPRL1	6.13e-05	5	57	2	CID014774638
Drug	RLH-033	OPRD1 OPRL1	6.13e-05	5	57	2	CID000190867
Drug	mirfentanil	OPRD1 OPRL1	6.13e-05	5	57	2	CID000060697
Drug	BRL 52537	OPRD1 OPRL1	6.13e-05	5	57	2	CID005244802
Drug	AC1L1TDW	OPRD1 OPRL1	6.13e-05	5	57	2	CID000060509
Drug	Mr2097	OPRD1 OPRL1	6.13e-05	5	57	2	CID005745592
Drug	remifentanil	CACNA1C OPRD1 OPRL1	7.01e-05	32	57	3	CID000060814
Drug	AC1L2TFU	OPRD1 OPRL1	9.18e-05	6	57	2	CID000128241
Drug	Etorphine	OPRD1 OPRL1	9.18e-05	6	57	2	DB01497
Drug	TEAF	PNKP LAMB2	9.18e-05	6	57	2	CID010219518
Drug	NIH10236	OPRD1 OPRL1	9.18e-05	6	57	2	CID006439828
Drug	DuP 747	OPRD1 OPRL1	9.18e-05	6	57	2	CID000132447
Drug	AC1L2OET	OPRD1 OPRL1	9.18e-05	6	57	2	CID000125331
Drug	AC1L3OP4	OPRD1 OPRL1	9.18e-05	6	57	2	CID000092720
Drug	beta-methyl-2',6'-dimethyltyrosine	OPRD1 OPRL1	9.18e-05	6	57	2	CID000189865
Drug	NSC612111	OPRD1 OPRL1	9.18e-05	6	57	2	CID000163346
Drug	AC1L1FBI	OPRD1 OPRL1	9.18e-05	6	57	2	CID000053641
Drug	KT-90	OPRD1 OPRL1	9.18e-05	6	57	2	CID005492465
Drug	RX8008M	OPRD1 OPRL1	9.18e-05	6	57	2	CID000162443
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; PC3; HT_HG-U133A	UBE2J1 NUDT11 APBB2 NR2F2 CYFIP2	1.25e-04	194	57	5	5854_DN
Drug	beta-FNA	THOP1 OPRD1 OPRL1	1.28e-04	39	57	3	CID005137129
Drug	Ctop	THOP1 OPRD1 OPRL1	1.28e-04	39	57	3	CID000002884
Drug	Tyr-ala-phe-gly	OPRD1 OPRL1	1.28e-04	7	57	2	CID005487532
Drug	GR89696	OPRD1 OPRL1	1.28e-04	7	57	2	CID000003505
Drug	EET-HO	OPRD1 OPRL1	1.28e-04	7	57	2	CID000135928
Drug	MET-CAMO	OPRD1 OPRL1	1.28e-04	7	57	2	CID006450159
Drug	AC1L2YDY	OPRD1 OPRL1	1.28e-04	7	57	2	CID000130992
Drug	phenylmorphan	OPRD1 OPRL1	1.28e-04	7	57	2	CID000146306
Drug	AC1Q6ZKG	OPRD1 OPRL1	1.28e-04	7	57	2	CID000031785
Drug	AC1L9PCU	OPRD1 OPRL1	1.28e-04	7	57	2	CID000451042
Drug	N-cyclopropylmethylnorazidomorphine	OPRD1 OPRL1	1.28e-04	7	57	2	CID005489191
Drug	beta-naltrexamine	OPRD1 OPRL1	1.28e-04	7	57	2	CID005486948
Drug	ICI-199,441	OPRD1 OPRL1	1.28e-04	7	57	2	CID003082717
Drug	NDTMB	OPRD1 OPRL1	1.28e-04	7	57	2	CID000134748
Drug	2-mercaptoacetate	OPRD1 OPRL1	1.28e-04	7	57	2	ctd:C017487
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A	CORO1A MYO9B APBB2 AR SECTM1	1.31e-04	196	57	5	1708_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	TUT4 MYO9B SIGLEC6 AR SECTM1	1.40e-04	199	57	5	3860_DN
Drug	AC1Q1ZY1	OPRD1 OPRL1	1.71e-04	8	57	2	CID000065964
Drug	ICI 204448	OPRD1 OPRL1	1.71e-04	8	57	2	CID000003683
Drug	phenazocine	OPRD1 OPRL1	1.71e-04	8	57	2	CID000014706
Drug	metazocine	OPRD1 OPRL1	1.71e-04	8	57	2	CID000062518
Drug	AC1L1B1Q	OPRD1 OPRL1	1.71e-04	8	57	2	CID000001246
Drug	AC1L2Y8M	OPRD1 OPRL1	1.71e-04	8	57	2	CID000130908
Drug	DIPPA	OPRD1 OPRL1	1.71e-04	8	57	2	CID000127914
Drug	14-methoxymetopon	OPRD1 OPRL1	1.71e-04	8	57	2	CID005486940
Drug	KT-89	OPRD1 OPRL1	1.71e-04	8	57	2	CID005748450
Drug	binaltorphimine	OPRD1 OPRL1	1.71e-04	8	57	2	CID005484197
Drug	N-methyl nalorphine	OPRD1 OPRL1	1.71e-04	8	57	2	CID005748235
Drug	AC1LBBLW	OPRD1 OPRL1	1.71e-04	8	57	2	CID000579851
Drug	dioxadrol	OPRD1 OPRL1	1.71e-04	8	57	2	CID000066269
Drug	Oxymorphone hydrazone	OPRD1 OPRL1	1.71e-04	8	57	2	CID009577748
Drug	Tyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone	OPRD1 OPRL1	1.71e-04	8	57	2	CID005492572
Drug	methyl (E)-4-[[(4R,4aR,7R,7aR,12bS)-3-(cyclopropylmethyl)-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]amino]-4-oxobut-2-enoate	THOP1 OPRD1 OPRL1	1.71e-04	43	57	3	CID016072169
Drug	Dam K	OPRD1 OPRL1	2.19e-04	9	57	2	CID005487344
Drug	AC1LD4H9	OPRD1 OPRL1	2.19e-04	9	57	2	CID000611919
Drug	M 285	OPRD1 OPRL1	2.19e-04	9	57	2	CID000020435
Drug	AC1Q7A0V	OPRD1 OPRL1	2.19e-04	9	57	2	CID000001250
Drug	Adenosine Monophosphate	NUDT11 NUDT10	2.19e-04	9	57	2	ctd:D000249
Drug	meptazinol	OPRD1 OPRL1	2.19e-04	9	57	2	CID000041049
Drug	MRZ 2549	OPRD1 OPRL1	2.19e-04	9	57	2	CID000134837
Drug	Syndyphalin	OPRD1 OPRL1	2.19e-04	9	57	2	CID000174117
Drug	profadol	OPRD1 OPRL1	2.74e-04	10	57	2	CID000009882
Drug	AC1LCF1O	OPRD1 OPRL1	2.74e-04	10	57	2	CID000627285
Drug	normetazocine	OPRD1 OPRL1	2.74e-04	10	57	2	CID000001208
Drug	me fit	OPRD1 OPRL1	2.74e-04	10	57	2	CID000127921
Drug	Bd 737	OPRD1 OPRL1	2.74e-04	10	57	2	CID000131252
Drug	Naloxone-6-hydrazone	OPRD1 OPRL1	2.74e-04	10	57	2	CID009576788
Drug	guanidinium-phosphate	ENPP1 AR	3.34e-04	11	57	2	CID000160593
Drug	PD117302	OPRD1 OPRL1	3.34e-04	11	57	2	CID000122115
Drug	Trimu-5	OPRD1 OPRL1	3.34e-04	11	57	2	CID005487273
Drug	AC1MI02C	OPRD1 OPRL1	3.34e-04	11	57	2	CID003035838
Drug	Wy-16,225	OPRD1 OPRL1	3.34e-04	11	57	2	CID000040841
Drug	O-desmethyltramadol	OPRD1 OPRL1	3.34e-04	11	57	2	CID000130829
Drug	AC1MICD4	OPRD1 OPRL1	3.34e-04	11	57	2	CID003021990
Drug	AC1LCENG	OPRD1 OPRL1	3.34e-04	11	57	2	CID000626667
Drug	lofexidine	OPRD1 OPRL1	3.34e-04	11	57	2	CID000030667
Drug	AC1L1I4J	OPRD1 OPRL1	3.34e-04	11	57	2	CID000004419
Drug	Deltorphin Ii	AR OPRD1 OPRL1	3.37e-04	54	57	3	CID000123795
Drug	Factrel	THOP1 ACTL8 AR OPRD1 OPRL1	3.74e-04	246	57	5	CID000036523
Drug	cyclazocine	OPRD1 OPRL1	4.00e-04	12	57	2	CID000019143
Drug	tilidine	OPRD1 OPRL1	4.00e-04	12	57	2	CID000030131
Drug	Tedam	OPRD1 OPRL1	4.00e-04	12	57	2	CID000124900
Drug	Tedapge	OPRD1 OPRL1	4.00e-04	12	57	2	CID000146381
Disease	Cardiac Arrhythmia	CACNA1C SGO1 OPRL1	1.37e-05	25	55	3	C0003811
Disease	Malignant tumor of prostate	ZFHX3 AR	1.22e-04	9	55	2	cv:C0376358
Disease	Neoplasm of the genitourinary tract	ZFHX3 AR	9.17e-04	24	55	2	cv:C0042065
Disease	Prostatic Neoplasms	NAGK LAMB2 ZFHX3 ADAMTS8 AR PYHIN1	9.83e-04	616	55	6	C0033578
Disease	Malignant neoplasm of prostate	NAGK LAMB2 ZFHX3 ADAMTS8 AR PYHIN1	9.83e-04	616	55	6	C0376358
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ADAMTS8 AR NR2F2	1.00e-03	105	55	3	DOID:9352 (implicated_via_orthology)
Disease	Subfertility, Female	AR NR2F2	1.25e-03	28	55	2	C0341869
Disease	Sterility, Postpartum	AR NR2F2	1.25e-03	28	55	2	C0038279
Disease	Female sterility	AR NR2F2	1.25e-03	28	55	2	C0917730
Disease	Female infertility	AR NR2F2	1.25e-03	28	55	2	C0021361
Disease	glycoprotein measurement	CORO1A DOCK7 ZFHX3	1.44e-03	119	55	3	EFO_0004555

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDKDTRILKCHVFRC	APBB2	516	Q92870
KSLFKEDCDRRCLFQ	ACTL8	186	Q9H568
DRCKLFCRARGRSEF	ADAMTS8	621	Q9UP79
CCVKLRALTDFFRKR	GCA	181	P28676
KCEIARFYKLHERRC	CORO1A	331	P31146
RDFDKCRFAGFCRKI	NAGK	206	Q9UJ70
FKKRAACLCFRSERE	NUDT10	16	Q8NFP7
CEGCKSFFKRSVRRN	NR2F2	96	P24468
CFERKRTKFIACDFL	IQCK	156	Q8N0W5
CVRRKTESIDKRFCF	OPHN1	321	O60890
SIDSCCRDRYFRRKE	KCNV1	146	Q6PIU1
RSRFQRALACFTKCF	FAM236A	56	A0A1B0GUQ0
IKKKRACFPFAFCRD	PMS2P5	71	A8MQ11
KKCFLCDSRRPFSAR	LAMB2	86	P55268
RECIRHFFRKRKCFV	GBP4	236	Q96PP9
RECIRRFFPKRKCFV	GBP6	221	Q6ZN66
KFRCGEKRLTRSLCA	ENPP1	151	P22413
FKKRAACLCFRSERE	NUDT11	16	Q96G61
CASRNDCTIDKFRRK	AR	596	P10275
FCSEVKRLCHAERRK	CYFIP2	136	Q96F07
MDETKCCCFFKRRKR	CSNK1G3	426	Q9Y6M4
CCCFFKRRKRKTIQR	CSNK1G3	431	Q9Y6M4
RKRLKCFRCGADKFD	RBM5	196	P52756
IKFCREARGKENRLC	MANF	61	P55145
LDENFKRCFRQLCRK	OPRD1	321	P41143
GCKEALLEEKRRFCF	BAIAP2L1	181	Q9UHR4
RFCRRKCRAAVKSNV	CACNA1C	511	Q13936
LRLCFKDFTKRCEDA	DOCK7	2061	Q96N67
RSRFQRALACFTKCF	FAM236B	56	A0A1B0GV22
CYLLLKVCFRRSKRA	GJB6	211	O95452
CEKGDKLRLFCFRLR	PYHIN1	366	Q6K0P9
RSRFQRALACFIKCF	FAM236C	56	P0DP71
RSRFQRALACFIKCF	FAM236D	56	A0A1B0GTK5
EVLYKCRKCRRSLFR	DUSP12	216	Q9UNI6
RFCELCGDRKLFQVR	PPP4R1L	166	Q9P1A2
ELLRADLCRDKFSKC	MFAP2	146	P55001
FKACFRKFCCASALR	OPRL1	326	P41146
FSTDKKLLLCIRCFR	RNF207	166	Q6ZRF8
CEICGRKFFRVDVLR	PRDM15	931	P57071
EFVSRFPDCRKCKLE	SGO1	541	Q5FBB7
FLCVCFIFRVKTRRK	SIGLEC6	361	O43699
TCGFRFCCTFKKRRL	SHISA9	101	B4DS77
RKKKDFSCADRLFAL	PNKP	301	Q96T60
CRICAFLLRKKRFGQ	AFAP1L1	221	Q8TED9
FCFTASRIDICLRKR	USP19	361	O94966
CRCSQQRREKKFFLL	SECTM1	171	Q8WVN6
AKFSDGEKCRREAFR	PHTF1	251	Q9UMS5
CKLRFDRIFFRAAAE	TDP2	311	O95551
ERRALAKKSQDFCCE	UBE2J1	136	Q9Y385
FERFFKAVNCRERKL	USP9Y	741	O00507
KCEECGKAFRRSTDR	ZNF141	396	Q15928
ECKECDKAFNRSDRL	ZNF404	496	Q494X3
CFECGKAFRRKLSLI	ZNF471	601	Q9BX82
KCDICGKSFRVRSRL	ZNF221	311	Q9UK13
RILFECRECKKTFTE	ZNF286B	296	P0CG31
TRRKVEEAFNCRCKE	THOP1	236	P52888
RFREILDLVCKRCFD	TUT4	946	Q5TAX3
ECKDCRKSFRQRAHL	ZNF583	521	Q96ND8
CRECERVFDKIKSRN	ZNF541	1291	Q9H0D2
RRCPFCRALFKAKTA	ZFHX3	2711	Q15911
TFCKLCLERGRAADR	LONRF3	176	Q496Y0
RCIRSNAEKKELCFD	MYO9B	851	Q13459