Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.53e-22	114	128	19	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	3.51e-21	124	128	19	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.52e-20	137	128	19	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 ATG4D USP17L15 USP17L8 USP17L13	8.11e-19	192	128	20	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 NRDC USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 ADAMTS20 USP17L22 ATG4D USP17L15 USP17L8 USP17L13	2.65e-11	654	128	23	GO:0008233
GeneOntologyMolecularFunction	mannosyltransferase activity	DPY19L2 DPY19L1 ALG9	7.50e-04	28	128	3	GO:0000030
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	OPRD1 OPRK1	8.38e-04	7	128	2	GO:0004985
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 TOR1A USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.23e-21	144	128	20	GO:0070646
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.26e-21	125	128	19	GO:0016579
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L7 ATG5 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 USP17L20 USP17L11 USP17L24 TOR1A TRIM49D1 USP17L5 C10orf90 USP17L19 USP17L18 IFIH1 FBXO38 USP17L17 HACE1 USP17L6P USP17L3 ZNRF1 UBR3 USP17L22 ATG4D USP17L15 USP17L8 USP17L13	2.39e-12	1074	128	30	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L7 ATG5 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 USP17L20 USP17L11 USP17L24 TOR1A TRIM49D1 USP17L5 C10orf90 USP17L19 USP17L18 IFIH1 FBXO38 USP17L17 HACE1 USP17L6P USP17L3 ZNRF1 UBR3 USP17L22 USP17L15 USP17L8 USP17L13	2.97e-12	1009	128	29	GO:0070647
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 DPY19L1 USP17L20 USP17L11 TOR1A USP17L5 CYP4F2 USP17L19 ATP8B2 TMCC3 USP17L18 CYP2R1 USP17L17 ALG9 USP17L6P USP17L3 NR3C2 USP17L22 USP17L15 USP17L8 USP17L13	1.31e-08	1293	127	27	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 DPY19L1 USP17L20 USP17L11 TOR1A USP17L5 CYP4F2 USP17L19 ATP8B2 TMCC3 USP17L18 CYP2R1 USP17L17 ALG9 USP17L6P USP17L3 NR3C2 USP17L22 USP17L15 USP17L8 USP17L13	1.44e-08	1299	127	27	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 PSEN2 USP17L1 DPY19L1 USP17L20 USP17L11 TOR1A USP17L5 CYP4F2 USP17L19 ATP8B2 TMCC3 USP17L18 CYP2R1 USP17L17 ALG9 USP17L6P USP17L3 NR3C2 USP17L22 USP17L15 USP17L8 USP17L13	2.25e-08	1327	127	27	GO:0042175
MousePheno	increased trophectoderm apoptosis	USP17L2 USP17L15 USP17L13	1.03e-05	8	81	3	MP:0012119
Domain	HABP4_PAI-RBP1	USP17L7 USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13	2.03e-29	16	125	14	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L7 USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13	2.03e-29	16	125	14	IPR006861
Domain	UCH	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	2.69e-22	71	125	17	PF00443
Domain	USP_2	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	2.69e-22	71	125	17	PS00973
Domain	USP_3	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	3.51e-22	72	125	17	PS50235
Domain	USP_dom	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	3.51e-22	72	125	17	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	3.51e-22	72	125	17	IPR001394
Domain	USP_CS	USP17L7 USP17L21 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	3.89e-21	66	125	16	IPR018200
Domain	USP_1	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13	1.10e-20	70	125	16	PS00972
Domain	Opioid_rcpt	OPRD1 OPRK1	2.64e-04	4	125	2	IPR001418
Domain	Dpy19	DPY19L2 DPY19L1	2.64e-04	4	125	2	PF10034
Domain	Dpy-19/Dpy-19-like	DPY19L2 DPY19L1	2.64e-04	4	125	2	IPR018732
Domain	ARM-type_fold	SMG1 DOCK11 IFT172 TRRAP NCAPG2 AP1G1 NUP188 NIPBL IPO11	4.65e-04	339	125	9	IPR016024
Domain	FAT	SMG1 TRRAP	6.55e-04	6	125	2	PS51189
Domain	FATC	SMG1 TRRAP	6.55e-04	6	125	2	PS51190
Domain	FATC_dom	SMG1 TRRAP	6.55e-04	6	125	2	IPR003152
Domain	PIK_FAT	SMG1 TRRAP	6.55e-04	6	125	2	IPR014009
Domain	FATC	SMG1 TRRAP	6.55e-04	6	125	2	SM01343
Domain	HEAT_REPEAT	SMG1 NCAPG2 NIPBL IPO11	1.25e-03	70	125	4	PS50077
Domain	zf-C2H2_6	ZNF136 ZNF652 ZBTB47 ZNF626 ZNF92 ZNF85 ZNF90 ZNF844	1.25e-03	314	125	8	PF13912
Pathway	REACTOME_RAS_PROCESSING	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	4.98e-28	45	99	18	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 TRRAP USP17L18 IFIH1 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.68e-18	191	99	20	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 TRRAP USP17L18 IFIH1 USP17L17 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	8.36e-16	221	99	19	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 TRRAP USP17L18 IFIH1 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.35e-15	262	99	20	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 TRRAP USP17L18 IFIH1 USP17L17 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.10e-13	299	99	19	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L7 RAF1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.33e-13	318	99	19	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L7 FBXW10B USP17L21 USP17L4 FBXW10 PCGF2 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 TRRAP GFPT1 USP17L18 IFIH1 FBXL18 USP17L17 ALG9 TTLL4 USP17L6P USP17L3 ADAMTS20 NR3C2 NUP188 USP17L22 USP17L15 USP17L8 USP17L13	1.15e-08	1389	99	30	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 FBXW10 PCGF2 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 TRRAP GFPT1 USP17L18 IFIH1 FBXL18 USP17L17 ALG9 TTLL4 USP17L3 ADAMTS20 NR3C2 NUP188 USP17L22 USP17L15 USP17L8 USP17L13	6.20e-07	1475	99	28	M19806
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.74e-42	21	129	18	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	3.70e-41	22	129	18	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.76e-40	24	129	18	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.41e-39	25	129	18	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	7.80e-39	26	129	18	35816173
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.28e-38	33	129	19	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.90e-38	34	129	19	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.32e-38	35	129	19	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.32e-38	35	129	19	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.33e-37	36	129	19	20147298
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	1.71e-37	29	129	18	32527007
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.73e-37	37	129	19	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	8.38e-32	50	129	18	31806660
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	1.29e-18	10	129	8	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	1.40e-17	12	129	8	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	8.47e-17	14	129	8	11793228
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L7 USP17L21 USP17L4 USP17L2 TRPA1 USP17L12 USP17L1 USP17L20 USP17L11 ZNF280C USP17L5 ARHGAP30 USP17L19 USP17L18 CLCN5 USP17L17 USP17L6P MMRN2 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.90e-16	674	129	23	37196079
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	2.10e-15	19	129	8	28067227
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	7.37e-10	81	129	8	12838346
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L2 USP17L15 USP17L13	1.99e-07	4	129	3	22984479
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 USP17L17	3.25e-07	119	129	7	28625976
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L7 USP17L4 USP17L1 USP17L3 USP17L8	9.78e-07	48	129	5	16421571
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF92 ZNF85 ZNF90	2.75e-06	8	129	3	2023909
Pubmed	The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.	OPRD1 OPRK1	1.37e-05	2	129	2	16331961
Pubmed	Identification of kappa- and delta-opioid receptor transcripts in immune cells.	OPRD1 OPRK1	1.37e-05	2	129	2	7649271
Pubmed	Role of efficient neurotransmitter release in barrel map development.	ADCY1 RIMS1	1.37e-05	2	129	2	16525048
Pubmed	Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.	OPRD1 OPRK1	1.37e-05	2	129	2	24923251
Pubmed	BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.	BRD4 NIPBL	1.37e-05	2	129	2	29379197
Pubmed	Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.	OPRD1 OPRK1	1.37e-05	2	129	2	8393575
Pubmed	μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice.	OPRD1 OPRK1	1.37e-05	2	129	2	24278116
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	1.37e-05	2	129	2	31400758
Pubmed	Regulations of opioid dependence by opioid receptor types.	OPRD1 OPRK1	1.37e-05	2	129	2	11316510
Pubmed	G-protein-coupled receptor heterodimerization modulates receptor function.	OPRD1 OPRK1	1.37e-05	2	129	2	10385123
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	1.37e-05	2	129	2	37450367
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	1.37e-05	2	129	2	7665159
Pubmed	The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.	OPRD1 OPRK1	1.37e-05	2	129	2	17622222
Pubmed	Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation.	TRPA1 ADCY1	1.37e-05	2	129	2	29270106
Pubmed	The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes.	BRD4 NIPBL	1.37e-05	2	129	2	31320616
Pubmed	Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.	OPRD1 OPRK1	1.37e-05	2	129	2	16712978
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF92 ZNF85 ZNF90	2.69e-05	16	129	3	8467795
Pubmed	A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.	NCOA3 ERH NIPBL	3.91e-05	18	129	3	26674342
Pubmed	Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.	OPRD1 OPRK1	4.09e-05	3	129	2	19032295
Pubmed	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.	OPRD1 OPRK1	4.09e-05	3	129	2	15090050
Pubmed	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.	OPRD1 OPRK1	4.09e-05	3	129	2	10082819
Pubmed	TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.	TEAD1 BRD4	4.09e-05	3	129	2	38374140
Pubmed	Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.	OPRD1 OPRK1	4.09e-05	3	129	2	18338799
Pubmed	Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.	OPRD1 OPRK1	4.09e-05	3	129	2	18537939
Pubmed	Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.	OPRD1 OPRK1	4.09e-05	3	129	2	12603260
Pubmed	Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.	IFIH1 BATF3	4.09e-05	3	129	2	19995959
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF	4.09e-05	3	129	2	31985401
Pubmed	Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.	OPRD1 OPRK1	4.09e-05	3	129	2	17676326
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF	4.09e-05	3	129	2	20139422
Pubmed	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.	OPRD1 OPRK1	4.09e-05	3	129	2	26692286
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	4.09e-05	3	129	2	25703008
Pubmed	Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.	OPRD1 OPRK1	4.09e-05	3	129	2	17374034
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF	4.09e-05	3	129	2	9784606
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF	4.09e-05	3	129	2	33656439
Pubmed	Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.	OPRD1 OPRK1	4.09e-05	3	129	2	34685631
Pubmed	Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.	RAF1 IFIH1	4.09e-05	3	129	2	16575407
Pubmed	Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.	OPRD1 OPRK1	4.09e-05	3	129	2	11504820
Pubmed	No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.	OPRD1 OPRK1	4.09e-05	3	129	2	15178356
Pubmed	Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.	OPRD1 OPRK1	4.09e-05	3	129	2	12431223
Pubmed	The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.	OPRD1 OPRK1	4.09e-05	3	129	2	28049031
Pubmed	Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.	OPRD1 OPRK1	4.09e-05	3	129	2	26946441
Pubmed	Nociception increases during opioid infusion in opioid receptor triple knock-out mice.	OPRD1 OPRK1	4.09e-05	3	129	2	17544222
Pubmed	Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.	OPRD1 OPRK1	4.09e-05	3	129	2	14745298
Pubmed	Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.	OPRD1 OPRK1	4.09e-05	3	129	2	8114680
Pubmed	Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.	OPRD1 OPRK1	4.09e-05	3	129	2	22752269
Pubmed	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.	OPRD1 OPRK1	4.09e-05	3	129	2	11032994
Pubmed	Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.	OPRD1 OPRK1	4.09e-05	3	129	2	25855262
Pubmed	Opioid receptors: from binding sites to visible molecules in vivo.	OPRD1 OPRK1	4.09e-05	3	129	2	18718480
Pubmed	Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.	OPRD1 OPRK1	4.09e-05	3	129	2	24874714
Pubmed	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.	OPRD1 OPRK1	4.09e-05	3	129	2	11826143
Pubmed	Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.	OPRD1 OPRK1	4.09e-05	3	129	2	18213616
Pubmed	Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.	OPRD1 OPRK1	4.09e-05	3	129	2	33555255
Pubmed	Enhanced humoral response in kappa-opioid receptor knockout mice.	OPRD1 OPRK1	4.09e-05	3	129	2	12507774
Pubmed	Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.	OPRD1 OPRK1	4.09e-05	3	129	2	14975676
Pubmed	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.	OPRD1 OPRK1	4.09e-05	3	129	2	11069979
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXW10B FBXW10 FBXO38 FBXL18	8.00e-05	61	129	4	15520277
Pubmed	Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.	PDE8B NR3C2	8.15e-05	4	129	2	22494929
Pubmed	Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).	AP1S1 AP1G1	8.15e-05	4	129	2	9653655
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRD1 OPRK1	8.15e-05	4	129	2	8941707
Pubmed	Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.	OPRD1 OPRK1	8.15e-05	4	129	2	12413885
Pubmed	Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.	OPRD1 OPRK1	8.15e-05	4	129	2	9502813
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 TRRAP USP17L18 USP17L17 NUP188 NIPBL IPO11	2.71e-06	318	118	11	int:FLT3
Cytoband	4p16.1	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	8.25e-20	79	129	13	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	7.97e-14	222	129	13	chr4p16
Cytoband	8p23.1	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.23e-06	154	129	6	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.55e-05	234	129	6	chr8p23
Cytoband	11p15.2	TEAD1 CYP2R1	8.03e-04	15	129	2	11p15.2
GeneFamily	Opioid receptors	OPRD1 OPRK1	1.15e-04	4	80	2	245
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	1.04e-03	11	80	2	559
Coexpression	MADAN_DPPA4_TARGETS	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	5.31e-25	86	125	18	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	8.92e-23	112	125	18	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 SLFN12 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	2.19e-21	160	125	19	MM1155
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L7 NCOA3 FBXW10B USP17L21 USP17L4 FBXW10 PCGF2 USP17L2 USP17L12 USP17L1 NRDC USP17L20 USP17L11 USP17L5 USP17L19 GFPT1 ZBED5 USP17L18 USP17L17 ALG9 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	6.19e-12	1072	125	26	MM1031
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 AOX1 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 ZNRF1 USP17L22 USP17L15 USP17L8 USP17L13	3.36e-11	647	125	20	MM981
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 GLRX3 USP17L20 USP17L11 AOX1 USP17L5 USP17L19 USP17L18 IFIH1 USP17L17 USP17L6P USP17L3 ZNRF1 ZNF85 USP17L22 USP17L15 USP17L8 USP17L13	1.64e-08	1226	125	23	MM979
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L7 TMIGD1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L19 EPG5 USP17L18 USP17L17 USP17L6P USP17L3 RIMS1 USP17L22 USP17L15 USP17L8 USP17L13	2.33e-07	1198	125	21	MM1062
Coexpression	GSE25123_WT_VS_PPARG_KO_MACROPHAGE_IL4_STIM_UP	USP17L2 IFT172 ZNF652 PTPRF CYP2R1 GUCA1B KLHL4	5.06e-05	200	125	7	M7954
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.27e-05	188	121	6	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.27e-05	188	121	6	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.31e-05	189	121	6	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.35e-05	190	121	6	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.43e-05	192	121	6	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	PSEN2 AXL TMCC3 RASGEF1B MMRN2 IPO11	1.51e-05	194	121	6	4199900d16623eca02d674d5ada7f0989e47955e
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.51e-05	194	121	6	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSEN2 SLC18A2 RASGEF1B MMRN2 IPO11 KLHL4	1.56e-05	195	121	6	df644b4c3ddccd34614ece5a2378000e6bc0fa10
Drug	cyclamate	OPRD1 OPRK1 CLCN5 TAS1R1	1.07e-05	28	113	4	CID000007533
Drug	SNC80	TRPA1 OPRD1 OPRK1 SLC18A2	1.63e-05	31	113	4	CID000123924
Drug	erinacine E	OPRD1 OPRK1	2.44e-05	2	113	2	CID005317180
Drug	Dynorphin (1-11)	OPRD1 OPRK1	2.44e-05	2	113	2	CID003086114
Drug	(-)-EKC	OPRD1 OPRK1	2.44e-05	2	113	2	CID000042800
Drug	2-aminooxazole	OPRD1 OPRK1	2.44e-05	2	113	2	CID000558521
Drug	MR-1353	OPRD1 OPRK1	2.44e-05	2	113	2	CID000197198
Drug	trefentanil	OPRD1 OPRK1	2.44e-05	2	113	2	CID000060727
Drug	TRK-820	TRPA1 OPRD1 OPRK1	4.16e-05	14	113	3	CID006445230
Drug	I06-1317	OPRD1 OPRK1 TAS1R1	4.16e-05	14	113	3	CID003081923
Drug	Tyr-w-mif-1	AOX1 OPRD1 OPRK1	5.19e-05	15	113	3	CID000132632
Drug	Iopanoic acid [96-83-3]; Up 200; 7uM; PC3; HT_HG-U133A	GLRX3 TBC1D9 IFIH1 AP1S1 CLCN5 PDE8B INVS	5.81e-05	197	113	7	6348_UP
Drug	TRK 820	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:C111212
Drug	Oxycodone	OPRD1 OPRK1	7.30e-05	3	113	2	DB00497
Drug	Hydromorphone	OPRD1 OPRK1	7.30e-05	3	113	2	DB00327
Drug	Codeine	OPRD1 OPRK1	7.30e-05	3	113	2	DB00318
Drug	Carfentanil	OPRD1 OPRK1	7.30e-05	3	113	2	DB01535
Drug	Morphine	OPRD1 OPRK1	7.30e-05	3	113	2	DB00295
Drug	Hydrocodone	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:D006853
Drug	3-Methylfentanyl	OPRD1 OPRK1	7.30e-05	3	113	2	DB01571
Drug	Heroin	OPRD1 OPRK1	7.30e-05	3	113	2	DB01452
Drug	3-Methylthiofentanyl	OPRD1 OPRK1	7.30e-05	3	113	2	DB01439
Drug	morphine-7,8-oxide	OPRD1 OPRK1	7.30e-05	3	113	2	CID005491901
Drug	Levorphanol	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:D007981
Drug	Levallorphan	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:D007977
Drug	NSC11411	OPRD1 OPRK1	7.30e-05	3	113	2	CID000408117
Drug	Buprenorphine	OPRD1 OPRK1	7.30e-05	3	113	2	DB00921
Drug	Levorphanol	OPRD1 OPRK1	7.30e-05	3	113	2	DB00854
Drug	Remifentanil	OPRD1 OPRK1	7.30e-05	3	113	2	DB00899
Drug	Nalbuphine	OPRD1 OPRK1	7.30e-05	3	113	2	DB00844
Drug	Fentanyl	OPRD1 OPRK1	7.30e-05	3	113	2	DB00813
Drug	Sufentanil	OPRD1 OPRK1	7.30e-05	3	113	2	DB00708
Drug	Ro 64-6198	OPRD1 OPRK1	7.30e-05	3	113	2	CID009844019
Drug	Propoxyphene	OPRD1 OPRK1	7.30e-05	3	113	2	DB00647
Drug	Butorphanol	OPRD1 OPRK1	7.30e-05	3	113	2	DB00611
Drug	Butorphanol	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:D002077
Drug	cyclorphan	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:C084603
Drug	up hit	OPRD1 OPRK1	7.30e-05	3	113	2	CID000129713
Drug	Alvimopan	OPRD1 OPRK1	7.30e-05	3	113	2	DB06274
Drug	dextrallorphan	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:C044130
Drug	14-phenylpropoxymetopon	OPRD1 OPRK1	7.30e-05	3	113	2	ctd:C478565
Drug	NSC612112	OPRD1 OPRK1	7.30e-05	3	113	2	CID000356432
Drug	indolin-3-one	OPRD1 OPRK1	7.30e-05	3	113	2	CID000230915
Drug	naloxazine	OPRD1 OPRK1	7.30e-05	3	113	2	CID003081567
Drug	fentanyl isothiocyanate	ADCY1 OPRD1 OPRK1	7.69e-05	17	113	3	CID000084008
Drug	acesulfame-K	OPRD1 OPRK1 TAS1R1	1.28e-04	20	113	3	CID000036573
Drug	Dynorphins	OPRD1 OPRK1	1.46e-04	4	113	2	ctd:D004399
Drug	AC1L5BQM	OPRD1 OPRK1	1.46e-04	4	113	2	CID000174892
Drug	Diprenorphine	OPRD1 OPRK1	1.46e-04	4	113	2	DB01548
Drug	3B-b	OPRD1 OPRK1	1.46e-04	4	113	2	CID000533975
Drug	picenadol	OPRD1 OPRK1	1.46e-04	4	113	2	CID000053076
Drug	sulforhodamine B acid chloride	OPRD1 OPRK1	1.46e-04	4	113	2	CID000065223
Drug	Menthol	TRPA1 OPRK1	1.46e-04	4	113	2	DB00825
Drug	Naltrexone	OPRD1 OPRK1	1.46e-04	4	113	2	DB00704
Drug	Methadyl Acetate	OPRD1 OPRK1	1.46e-04	4	113	2	ctd:D008692
Drug	7-hydroxymitragynine	OPRD1 OPRK1	1.46e-04	4	113	2	ctd:C482678
Drug	dulcin	OPRD1 OPRK1 TAS1R1	1.48e-04	21	113	3	CID000009013
Drug	saccharin	ADCY1 OPRD1 OPRK1 TAS1R1	1.50e-04	54	113	4	CID000005143
Drug	beta-CNA	ADCY1 OPRD1 OPRK1	1.96e-04	23	113	3	CID005486190
Drug	AC1L4LFZ	OPRD1 OPRK1 SLC18A2	2.23e-04	24	113	3	CID000187741
Drug	Dihydromorphine	OPRD1 OPRK1	2.42e-04	5	113	2	DB01565
Drug	metkephamid acetate	OPRD1 OPRK1	2.42e-04	5	113	2	CID005464183
Drug	R-84760	OPRD1 OPRK1	2.42e-04	5	113	2	CID000133035
Drug	Naloxone	OPRD1 OPRK1	2.42e-04	5	113	2	DB01183
Drug	DALECK	OPRD1 OPRK1	2.42e-04	5	113	2	CID015942760
Drug	GPA 1657	OPRD1 OPRK1	2.42e-04	5	113	2	CID000030503
Drug	RLH-033	OPRD1 OPRK1	2.42e-04	5	113	2	CID000190867
Drug	Mr2097	OPRD1 OPRK1	2.42e-04	5	113	2	CID005745592
Drug	K 185	OPRD1 OPRK1	2.42e-04	5	113	2	CID005311198
Drug	AC1L2FKQ	OPRD1 OPRK1	2.42e-04	5	113	2	CID000020114
Drug	Tyr-tic-phe-phe-OH	OPRD1 OPRK1	2.42e-04	5	113	2	CID003035452
Drug	ICI 197067	OPRD1 OPRK1	2.42e-04	5	113	2	CID003081077
Drug	oxymorphamine	OPRD1 OPRK1	2.42e-04	5	113	2	CID000134844
Drug	mirfentanil	OPRD1 OPRK1	2.42e-04	5	113	2	CID000060697
Drug	Sc 39566	OPRD1 OPRK1	2.42e-04	5	113	2	CID000130018
Drug	BRL 52537	OPRD1 OPRK1	2.42e-04	5	113	2	CID005244802
Drug	AC1L1TDW	OPRD1 OPRK1	2.42e-04	5	113	2	CID000060509
Drug	Aconitine	RAF1 TRPA1 OPRD1	2.53e-04	25	113	3	ctd:D000157
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	4.49e-34	46	122	19	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13	4.63e-30	69	122	19	DOID:1682 (implicated_via_orthology)
Disease	Congenital muscular hypertrophy-cerebral syndrome	BRD4 NIPBL	1.68e-04	5	122	2	C1802395
Disease	Cornelia de Lange Syndrome 3	BRD4 NIPBL	1.68e-04	5	122	2	C1853099
Disease	Cornelia de Lange Syndrome 1	BRD4 NIPBL	1.68e-04	5	122	2	C4551851
Disease	psoriasis, coronary artery disease	COQ10A IFIH1	1.68e-04	5	122	2	EFO_0000676, EFO_0001645
Disease	De Lange syndrome	BRD4 NIPBL	2.52e-04	6	122	2	cv:C0270972
Disease	Cornelia De Lange Syndrome	BRD4 NIPBL	4.67e-04	8	122	2	C0270972
Disease	Nephronophthisis	IFT172 INVS	5.99e-04	9	122	2	cv:C0687120
Disease	Polycystic Kidney, Autosomal Dominant	BRD4 ALG9	5.99e-04	9	122	2	C0085413
Disease	Congenital Heart Defects	TRRAP BRD4 NIPBL	8.07e-04	44	122	3	C0018798
Disease	Cardiomyopathy, Dilated	RAF1 PSEN2 NR3C2	1.04e-03	48	122	3	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	RAF1 PSEN2 NR3C2	1.17e-03	50	122	3	C1449563
Disease	Modic type vertebral endplate changes	OPRK1 PTPRD	1.28e-03	13	122	2	HP_0030775
Disease	Withdrawal Symptoms	ADCY1 OPRD1 OPRK1	1.80e-03	58	122	3	C0087169
Disease	Drug Withdrawal Symptoms	ADCY1 OPRD1 OPRK1	1.80e-03	58	122	3	C0086189
Disease	Substance Withdrawal Syndrome	ADCY1 OPRD1 OPRK1	1.80e-03	58	122	3	C0038587
Disease	FEV change measurement, response to bronchodilator	SYCP2L NWD1 UBR3	1.80e-03	58	122	3	EFO_0005921, GO_0097366
Disease	Rolandic epilepsy	DPY19L2 NR3C2	1.96e-03	16	122	2	Orphanet_1945
Disease	neuritic plaque measurement	CYP4F2 C10orf90 RNF150 HACE1 BATF3 RIMS1	3.36e-03	349	122	6	EFO_0006798
Disease	Ovarian Serous Adenocarcinoma	RAF1 TRRAP	4.05e-03	23	122	2	C1335177

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPVKNRAEFMCHMKP	EPG5	521	Q9HCE0
RAEFMCHMKPSERKP	EPG5	526	Q9HCE0
ACKLMGERKFHRIIM	CXorf58	146	Q96LI9
CDIIKHPMDMSTIKS	BRD4	391	O60885
RLHLMPFKDRATSMC	ABCA12	2376	Q86UK0
VCKKFGLHVSRMMLA	ALG9	161	Q9H6U8
MVGKYERCLMAFKHP	FBXW10	601	Q5XX13
MQVVLARKPKMCSFL	AP1S1	36	P61966
LMSFRPIKMDAQEHK	CRYBB1	136	P53674
ELVMDMFKRLKVPVH	ADPRM	91	Q3LIE5
PSKDAIEAHFMSCMK	ATG5	116	Q9H1Y0
KEHEKMCPLLLCPMN	BATF3	96	Q9NR55
NPRCKEMKVTKYHVM	ADAMTS20	416	P59510
IRMACEDKFTKMIPR	AOX1	1311	Q06278
KMFCMKKRTPAEART	ATP8B2	381	P98198
MCKLAEQMPRLLGHK	NWD1	351	Q149M9
MSLHDCLMKALKVRG	RAF1	76	P04049
MCERSPDMLAHFRKL	AP1G1	201	O43747
MVGKYERCLMAFKHP	FBXW10B	601	O95170
RPALMDDRKHKICSM	PATL1	551	Q86TB9
IMPMDIKGIARTCSH	NSUN3	286	Q9H649
HYPMLMSKKICCLMV	OR2AK2	146	Q8NG84
VMRAVVKSPIMCHEK	NR3C2	176	P08235
RLKKLTHAAPCMLFM	GLRX3	136	O76003
DCQKVKVMYRMAHKP	MMRN2	91	Q9H8L6
YKDCMLMSHLEEPKV	IPO11	891	Q9UI26
KPLHYMTIMNKKVCV	OR4K17	131	Q8NGC6
LIKRMMIKCADVANP	PDE8B	771	O95263
GVCKMYEEHLKRMNP	ERH	31	P84090
LECPELMSRFMHIIK	HACE1	506	Q8IYU2
LMSRFMHIIKAQPFK	HACE1	511	Q8IYU2
LFSKIRPQLMVKHAM	NIPBL	2011	Q6KC79
LKLFLTPHMCVMASL	DPY19L1	471	Q2PZI1
EKMVMCRVKVPHTFA	PRKD3	261	O94806
RKFMSHVIRTLKMEC	LRRC37B	816	Q96QE4
ILIMRLKMFLTPHMC	DPY19L2	551	Q6NUT2
LKMFLTPHMCVMASL	DPY19L2	556	Q6NUT2
TEICMPVKKKHRARM	RASGEF1B	271	Q0VAM2
CQKLLMEAMKYHLLP	KLHL4	396	Q9C0H6
QAHKLAMKCMRPEDV	IFT172	956	Q9UG01
MMSVDRYIAVCHPVK	OPRD1	141	P41143
EAMLKCVVRDMAKPA	RIMS1	51	Q86UR5
LRCPAAMTVMHLAKF	PCGF2	166	P35227
VLKDCPKMMFIHATR	FBXO38	941	Q6PIJ6
PKMMFIHATRCRVLK	FBXO38	946	Q6PIJ6
QLMSVMISKHDCLFP	ARHGAP24	316	Q8N264
RCEPFTMKMLKDIKE	ERVK-5	306	Q9HDB9
KHIRSGDPMILSCLM	GLG1	516	Q92896
LMHCRKMFKAEIPFS	ADCY1	511	Q08828
QCPKMRRHAFELKML	DOCK11	231	Q5JSL3
KAPMSLVMFRFAIEH	DNAH3	2401	Q8TD57
FADRPCLPLFMKMTK	CYP2R1	106	Q6VVX0
MKDRMSKVPCYLIVL	COL6A5	536	A8TX70
FAHKTLAMDVMKPRR	CLCN5	646	P51795
MVKPHMVKAVCTDGK	COQ10A	151	Q96MF6
ALCRNIPHMKGKSAM	FASTKD1	786	Q53R41
MMVHKGLDLPCLKIR	IFIH1	971	Q9BYX4
NMIIRCMVPEHFEKT	GJE1	156	A6NN92
AHLPFLTMCMKESLR	CYP4F2	376	P78329
VMLTKLREMGREKCH	PTPRF	1736	P10586
VMLTKLREMGREKCH	PTPRD	1741	P23468
FAKMPSAMCSKIHVA	ARHGAP30	946	Q7Z6I6
TDVMKHTPLFRACEM	INVS	386	Q9Y283
RCLKRMHIKAMPEDA	PHF20L1	126	A8MW92
MMSVDRYIAVCHPVK	OPRK1	151	P41145
DHRTCPMCKMNILKA	RNF150	311	Q9ULK6
HYCDLLRKMNMPFVK	SPATA48	31	A4D263
PFIDEAKRLRAMHMK	SOX21	56	Q9Y651
TIAKFVSPMMKSRCH	TMCC3	431	Q9ULS5
PVIMIIMRDHTYAKC	GFPT1	606	Q06210
YMPALSDMLKHCKRL	FBXL18	576	Q96ME1
KKFVMECPSGTLFMH	GUCA1B	26	Q9UMX6
MREKHTALMKPIVFA	SMG1	2006	Q96Q15
KSHTFNCRMLMKTPH	NCOA3	191	Q9Y6Q9
KPLHYMAIMSNKVCK	OR6C68	126	A6NDL8
SLMMHLIFCKDFEIP	OR7D2	161	Q96RA2
LLMIRADSCLHKPMY	OR8S1	46	Q8NH09
MAMVKNFVAKRHIPF	APOL5	256	Q9BWW9
VFKDDRCKIPLFMLM	NCAPG2	661	Q86XI2
FKPKERCISEKEMHM	C10orf90	636	Q96M02
FHCTSPRKMAFAKMD	ATG4D	376	Q86TL0
MFTVDAMKKACLPGH	USP17L3	166	A6NCW0
PIEMAVKEKISMFCH	CTPS2	221	Q9NRF8
KRHEMVDKTPVMCSH	ZNF92	66	Q03936
PECMKVLLDFCMLHS	TRPA1	631	O75762
EAFSCIPSMRRHMIK	ZNF136	371	P52737
IMKLCMKDKDPHSET	TMIGD1	246	Q6UXZ0
PLEYKHLKMCIRVEM	TOR1A	271	O14656
ECQAFMAHTMPKLKA	TAS1R1	366	Q7RTX1
MFTVDAMKKACLPGH	USP17L4	166	A6NCW7
RKKFPLSEGMCHLMK	SYCP2L	201	Q5T4T6
LVKYFDKPVCMMARI	TBC1D9	1226	Q6ZT07
MFTVDAMKKACLPGH	USP17L18	166	D6R9N7
MFTVDAMKKACLPGH	USP17L5	166	A8MUK1
AVCMKEFDHPNVMRL	AXL	586	P30530
MFTVDAMKKACLPGH	USP17L21	166	D6R901
MFTVDAMKKACLPGH	USP17L13	166	C9JLJ4
VMHMEEPCFDFLRTK	NRDC	941	O43847
CVMFVLKEMLPSYHK	NUP188	706	Q5SRE5
KHVIMLFVPVTLCMI	PSEN2	86	P49810
KSIRKMPVHHFCMEK	SLFN12	266	Q8IYM2
MFTVDAMKKACLPGH	USP17L19	166	D6RCP7
MFTVDAMKKACLPGH	USP17L1	166	Q7RTZ2
RKHMVAHTKDMPFTC	ZBTB47	536	Q9UFB7
KMHTRMRPYKCKTVE	ZNF844	356	Q08AG5
KRNEMIAKPSVMCSH	ZNF626	66	Q68DY1
MAARISDPKLFVKHM	TOPAZ1	1641	Q8N9V7
MFTVDAMKKACLPGH	USP17L12	166	C9JPN9
LLIKPCAKDVVMRMF	ZBED5	216	Q49AG3
KRHEMIAKSPVMCFH	ZNF90	66	Q03938
MMPQPLRKDHFTCIV	UBR3	1546	Q6ZT12
MFTVDAMKKACLPGH	USP17L24	166	Q0WX57
LRGTYAELMKMCHKP	TRIM49D1	226	C9J1S8
AELMKMCHKPDVELL	TRIM49D1	231	C9J1S8
AHCFINMKSPMVRKY	TRAPPC8	546	Q9Y2L5
MFTVDAMKKACLPGH	USP17L7	166	P0C7H9
MFTVDAMKKACLPGH	USP17L8	166	P0C7I0
KRHEIMVAKPTVMCS	ZNF85	66	Q03923
MKHCCPDMITKFLGV	ZNF280C	256	Q8ND82
MFTVDAMKKACLPGH	USP17L6P	166	Q6QN14
SPMCEYMINFIHKLK	TEAD1	356	P28347
MFTVDAMKKACLPGH	USP17L22	166	D6RA61
KHMVAHTKDMPFTCE	ZNF652	346	Q9Y2D9
KCRMAPEHVTAQKMK	TTLL4	966	Q14679
AILMDHNCPIKTKMY	SLC18A2	481	Q05940
MFTVDAMKKACLPGH	USP17L15	166	C9J2P7
MFTVDAMKKACLPGH	USP17L17	166	D6RBQ6
RMFMSFLKHKDARPL	TRRAP	1586	Q9Y4A5
MPKSSLAKHMASCRL	SNRNP48	66	Q6IEG0
EMEMHFIMCLSKPRL	ZNRF1	156	Q8ND25
MFTVDAMKKACLPGH	USP17L2	166	Q6R6M4
MFTVDAMKKACLPGH	USP17L20	166	D6RJB6
LIHMEMGKSCIKIPR	ZFYVE16	1246	Q7Z3T8
MFTVDAMKKACLPGH	USP17L11	166	C9JVI0
GAIVCKLDMHKKMFR	NAA30	266	Q147X3