Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF14 ZNF133 ZNF668 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441

1.67e-0914596321GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF14 ZNF133 ZNF668 ZNF530 ZNF391 ZNF358 ZNF689 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441

6.09e-0914126320GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF14 ZNF668 ZNF660 ZNF530 ZNF358 ZNF689 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF251 ZNF768 ZNF568 ZFP62

1.89e-0712446317GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF14 ZNF668 ZNF660 ZNF530 ZNF358 ZNF689 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF251 ZNF768 ZNF568 ZFP62

2.56e-0712716317GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF14 ZNF668 ZNF358 ZNF521 E4F1 ZNF580 ZNF225 ZFP62

3.63e-04560638GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF14 ZNF668 ZNF358 ZNF521 E4F1 ZNF580 ZNF225 ZFP62

3.90e-04566638GO:0001216
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

PRDM9 KMT2B

4.34e-0410632GO:0140999
DomainZINC_FINGER_C2H2_2

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF593 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

1.67e-187756425PS50157
DomainZINC_FINGER_C2H2_1

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF593 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

1.77e-187776425PS00028
Domainzf-C2H2

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

1.94e-186936424PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

2.01e-186946424IPR013087
DomainZnf_C2H2-like

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF593 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

3.15e-187966425IPR015880
DomainZnf_C2H2

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF593 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

4.11e-188056425IPR007087
DomainZnF_C2H2

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF593 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441 ZNF687

4.49e-188086425SM00355
Domain-

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441

1.96e-1767964233.30.160.60
Domainzf-C2H2_6

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF256 ZKSCAN8 ZNF521 E4F1 ZNF225 ZNF442 ZNF251 ZNF568 ZFP62

3.00e-163146417PF13912
DomainKRAB

ZNF14 ZNF133 PRDM9 ZNF530 ZNF689 ZNF256 ZKSCAN8 ZNF534 ZNF225 ZNF442 ZNF251 ZNF568 ZNF441

2.07e-103586413PF01352
DomainKRAB

ZNF14 ZNF133 PRDM9 ZNF530 ZNF689 ZNF256 ZKSCAN8 ZNF534 ZNF225 ZNF442 ZNF251 ZNF568 ZNF441

3.00e-103696413SM00349
DomainKRAB

ZNF14 ZNF133 PRDM9 ZNF530 ZNF689 ZNF256 ZKSCAN8 ZNF534 ZNF225 ZNF442 ZNF251 ZNF568 ZNF441

3.10e-103706413IPR001909
DomainKRAB

ZNF14 ZNF133 ZNF530 ZNF689 ZNF256 ZKSCAN8 ZNF534 ZNF225 ZNF442 ZNF251 ZNF568 ZNF441

2.75e-093586412PS50805
DomainFRG2

FRG2 FRG2C

3.46e-053642PF15315
DomainFRG2

FRG2 FRG2C

3.46e-053642IPR026245
DomainArfGap

ACAP2 AGAP2

4.42e-0329642SM00105
DomainArfGap

ACAP2 AGAP2

4.42e-0329642PF01412
DomainARFGAP

ACAP2 AGAP2

4.42e-0329642PS50115
DomainArfGAP

ACAP2 AGAP2

4.42e-0329642IPR001164
DomainCNMP_BINDING_1

PRKG2 KCNH4

5.37e-0332642PS00888
DomainCNMP_BINDING_2

PRKG2 KCNH4

5.37e-0332642PS00889
DomaincNMP

PRKG2 KCNH4

6.04e-0334642SM00100
DomaincNMP_binding

PRKG2 KCNH4

6.04e-0334642PF00027
DomaincNMP-bd_dom

PRKG2 KCNH4

6.39e-0335642IPR000595
DomainCNMP_BINDING_3

PRKG2 KCNH4

6.39e-0335642PS50042
DomaincNMP-bd-like

PRKG2 KCNH4

7.51e-0338642IPR018490
DomainPH

SPTBN5 TIAM1 ACAP2 AGAP2

7.88e-03229644PF00169
DomainSET

PRDM9 KMT2B

8.70e-0341642PF00856
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF14 ZNF133 ZNF668 KMT2B ZNF660 ZNF530 ZNF689 ZNF256 ZKSCAN8 ZNF521 ZNF225 ZNF442 ZNF568 ZNF441

5.03e-0513874414M734
Pubmed

The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells.

TIAM1 ACAP2

1.06e-05366230212824
Pubmed

FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients.

FRG2 FRG2C

1.06e-05366215520407
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

ZNF689 ZKSCAN8 EPB41L5 RPL3 ZNF768

1.18e-0515566534921745
Pubmed

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

FAM47A ZFP62

3.53e-05566217924679
Pubmed

Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.

ZNF14 ZNF133

5.29e-0566627649249
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF668 KMT2B UBN1 C16orf87 FIZ1 ZKSCAN8 E4F1 RPL3 ZNF768 ZNF687

1.56e-041294661030804502
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2B UBN1 SUGP2 PCNX1 WNK1 ZDHHC8 ABCA7 SDHA ZNF687

2.33e-04110566935748872
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF358 ZKSCAN8 ZNF521 E4F1 ZNF580 ZNF593 ZNF687

3.90e-0470966722988430
Pubmed

Docking motif-guided mapping of the interactome of protein phosphatase-1.

DDX31 UBN1 WNK1

4.83e-048066319389623
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TBC1D10C ZNF521 LUZP1

5.77e-048566315449545
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SULF2 PCNX1 ALPK1 WNK1

8.98e-0422566412168954
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

TIAM1 ZDHHC8 LUZP1 AGAP2

9.90e-0423166416452087
Pubmed

Functional genomics identifies therapeutic targets for MYC-driven cancer.

SULF2 ALPK1 WNK1

1.01e-0310366322623531
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KMT2B SUGP2 WNK1

1.04e-031046639205841
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

TBC1D10C DDX31 KMT2B SUGP2 RPL3 LUZP1 ZNF687

1.11e-0384766735850772
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

UBN1 WNK1 ACAP2 ZNF768 LUZP1 ZNF687

1.41e-0364566625281560
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

ZNF668 SULF2 EPB41L5 RPL3 ZFP62 SDHA

1.52e-0365566635819319
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

ZNF660 ZNF530 ZNF256 EPB41L5 ZNF225 ZNF568 KCNH4

1.72e-0391566732393512
Pubmed

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

EPB41L5 ZNF568

1.80e-033366215755804
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

ZKSCAN8 EPB41L5 ACAP2 RPL3 ZNF568 ADPGK USP19

1.83e-0392566728986522
InteractionFGF13 interactions

DDX31 ZNF358 ZKSCAN8 EPB41L5 RPL3 ZNF768 ZFP62

7.84e-08117637int:FGF13
InteractionANOS1 interactions

ZNF668 DDX31 ZKSCAN8 RPL3 ZNF768 ZFP62

5.60e-06143636int:ANOS1
InteractionNOTCH2 interactions

ZNF668 SULF2 ZNF358 ZNF689 FIZ1 ZKSCAN8 E4F1 ZNF768 ZNF687

6.31e-06423639int:NOTCH2
InteractionFGFBP1 interactions

DDX31 SUGP2 ZKSCAN8 EPB41L5 RPL3 ZNF768 ZFP62

1.52e-05257637int:FGFBP1
InteractionZNF467 interactions

ZNF668 DDX31 ZNF689 ZKSCAN8 ZNF768 ZFP62

2.02e-05179636int:ZNF467
InteractionZNF346 interactions

ZNF668 DDX31 SUGP2 ZKSCAN8 EPB41L5 RPL3 ZNF768 ZFP62

2.20e-05377638int:ZNF346
InteractionSRSF6 interactions

ZNF668 DDX31 ZNF358 ZNF689 ZKSCAN8 EPB41L5 RPL3 ZNF768 ZFP62

2.50e-05503639int:SRSF6
InteractionAPOBEC3C interactions

ZNF668 DDX31 ZNF689 ZKSCAN8 ZNF768 ZFP62

2.58e-05187636int:APOBEC3C
InteractionRNF151 interactions

ZNF668 DDX31 ZNF689 EPB41L5 RPL3

4.13e-05123635int:RNF151
InteractionZNF668 interactions

ZNF668 DDX31 SUGP2 ZKSCAN8 RPL3 ZFP62

7.42e-05226636int:ZNF668
InteractionMAGEB2 interactions

ZNF668 DDX31 ZNF689 ZKSCAN8 EPB41L5 RPL3 ZNF768

1.06e-04349637int:MAGEB2
InteractionDGCR8 interactions

ZNF668 DDX31 ZNF689 EPB41L5 RPL3 ZFP62

1.08e-04242636int:DGCR8
InteractionLTBP2 interactions

ZNF358 E4F1 ZNF251 ZNF768

1.45e-0485634int:LTBP2
InteractionNPM3 interactions

ZNF668 DDX31 EPB41L5 RPL3 ZNF768 ZFP62

1.67e-04262636int:NPM3
InteractionNEIL1 interactions

ZNF668 DDX31 EPB41L5 RPL3 ZNF768 ZFP62

2.21e-04276636int:NEIL1
InteractionH1-7 interactions

ZNF668 DDX31 EPB41L5 E4F1 ZFP62

2.42e-04179635int:H1-7
InteractionPRKRA interactions

ZNF668 DDX31 ZKSCAN8 EPB41L5 RPL3 ZNF768 ZFP62

2.45e-04400637int:PRKRA
CytobandEnsembl 112 genes in cytogenetic band chr19q13

SRRM5 KMT2B ZNF530 FIZ1 ZNF256 ZNF534 ZNF580 ZNF225 ZNF568

5.10e-051192669chr19q13
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ZNF14 SUGP2 ZNF358 ZNF442 ABCA7 ZNF441

1.01e-03797666chr19p13
Cytoband3q22.1

COL6A6 ASTE1

1.69e-03426623q22.1
Cytoband16p11.2

ZNF668 ZNF689 ZNF768

2.68e-0319166316p11.2
Cytoband4q25

CYP2U1 ALPK1

4.24e-03676624q25
Cytoband19p13.2

ZNF358 ZNF442 ZNF441

4.45e-0322966319p13.2
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF14 ZNF133 ZNF668 PRDM9 ZNF660 ZNF530 ZNF391 ZNF358 ZNF689 FIZ1 ZNF256 ZKSCAN8 ZNF521 ZNF534 E4F1 ZNF580 ZNF225 ZNF442 ZNF251 ZNF768 ZNF568 ZFP62 ZNF441

5.12e-20718482328
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ACAP2 AGAP2

9.15e-04174821291
GeneFamilyArfGAPs

ACAP2 AGAP2

3.46e-0333482395
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

PRDM9 KMT2B

3.67e-0334482487
Diseaseselenium measurement

ZNF14 ZNF521

1.59e-0329602EFO_0006331
Diseasebody surface area

UBN1 E4F1 PRKG2 WNK1 RPL3 LUZP1

1.93e-03643606EFO_0022196
Diseaseblood barium measurement

SULF2 TIAM1

2.19e-0334602EFO_0021528
Diseaseresponse to efavirenz, virologic response measurement

TIAM1 LGI1

6.25e-0358602EFO_0006904, EFO_0006906
Diseaseatrial fibrillation

SULF2 ZNF689 E4F1 ALPK1

6.89e-03371604EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
HGRSKSRASDLTRIH

ADPGK

366

Q9BRR6
RSGKSSLIHRFLTGS

AGAP2

416

Q99490
HRSLGVHFSKVRSLT

ACAP2

441

Q15057
TSSKGRRHHRILGLL

ASTE1

246

Q2TB18
HLKGRFAAGHTLTLR

ABCA7

2011

Q8IZY2
KAAFGLTTVHRRLHG

ALPK1

356

Q96QP1
LLKIHSAAGRHRAFS

OR10W1

216

Q8NGF6
LSGRHGSTFRELHLL

KATNB1

636

Q9BVA0
HRTASAHKSGRRRTG

PCNX1

551

Q96RV3
HLRFRSSRSGRLSLH

FAM214B

486

Q7L5A3
HTLLSKGFRGASPHR

CT83

96

Q5H943
RSRTVLHRLTGHFGR

KCNH4

171

Q9UQ05
RGHARLRHLSFSGMS

KMT2B

2446

Q9UMN6
SHFHVSTRTRGDGRK

PCDHB15

176

Q9Y5E8
RSLHLGHVAKSFGLR

DDX31

736

Q9H8H2
HRKTSGLVSLHSRRG

PRKG2

106

Q13237
GRGFSNKSHLLRHQR

PRDM9

726

Q9NQV7
SHSTLRHFGLGKLSL

CYP2U1

181

Q7Z449
HRGSSRACTGRSKRH

FRG2C

146

A6NGY1
ACTGHSKRHRSRALG

FRG2

151

Q64ET8
KSSHRSGFIRLGSRF

EPB41L5

331

Q9HCM4
SHSDHIRRGRGRPKS

C16orf87

91

Q6PH81
SLRGLRAHQRSHSSG

CACNA1I

2076

Q9P0X4
SSKGRHERTKFRGHG

LUZP1

366

Q86V48
FSSRSSLGRHLKRQH

FIZ1

116

Q96SL8
HLRLEHSKTRRGSSL

FAM47A

336

Q5JRC9
GASFRTKGSLIRHHR

E4F1

226

Q66K89
GSRRKTAAHGRRGHT

COL6A6

1546

A6NMZ7
SALKSHRTRGHGRGD

RXFP3

186

Q9NSD7
TGHSLLHTLYGRSLR

SDHA

196

P31040
HGSLGFLPRKRSSRH

RPL3

11

P39023
RHSKRKTAGGLHGRR

OVCH1

911

Q7RTY7
CERLRGRHGRKHTFS

SPTBN5

3596

Q9NRC6
GRHGRKHTFSLRLTS

SPTBN5

3601

Q9NRC6
KRLGSLRLSLHSFRH

C10orf105

91

Q8TEF2
SHAAGITGSRHRTRL

USP19

66

O94966
GFLSPSSVRRHKRTH

ZNF441

316

Q8N8Z8
RAGLRKHSRTHSSVR

ZNF668

556

Q96K58
RASLSIHKRGHTGER

ZNF568

626

Q3ZCX4
LGRKHTSRSLRLSHK

TIAM1

21

Q13009
RLSHKTRRTRHASSG

TIAM1

31

Q13009
RSGSQKRTHSRVRSH

SRRM5

291

B3KS81
TRGKTFHGLLTRARG

TBC1D10C

411

Q8IV04
ICRRGFLSSSSLHGH

ZNF521

206

Q96K83
SSSLIRHRRSHTGER

ZNF256

531

Q9Y2P7
QTLLSSGTRLKHHGR

SUGP2

701

Q8IX01
KAFSRSSGLISHHRV

ZNF660

141

Q6AZW8
GKGFCRSSTLLQHHR

ZNF768

491

Q9H5H4
GNSRLARHRKIHTGG

ZNF534

406

Q76KX8
SSLRAAGHHSLFRRI

PHOSPHO1

131

Q8TCT1
MGRSRRTGAHRAHSL

ZNF593

1

O00488
FSRRSGLYVHRKLHT

ZNF225

241

Q9UK10
CGRGFSLKSHLSRHR

ZNF133

611

P52736
FTRSRFLRGHEKTHT

ZNF442

581

Q9H7R0
AFRRSGSLAIHRSTH

ZNF689

381

Q96CS4
GKTFGLNSHLRLHRR

ZNF251

271

Q9BRH9
LFKESRRGHGHLTSI

UBN1

571

Q9NPG3
FSSRTLISHKRVHLG

ZFP62

711

Q8NB50
SRHRFISHKKRRGVG

ZNF687

1151

Q8N1G0
RSLSLKASSRRGGDH

ZDHHC8

431

Q9ULC8
SSGFLRHRKAHGRTR

ZNF530

251

Q6P9A1
QSSGLFRHRRAHTKT

ZNF530

446

Q6P9A1
GKSFSQSSGLLRHRR

ZNF530

581

Q6P9A1
GRHEGRTTKRHYRKS

WNK1

1091

Q9H4A3
GKAFKRSSHLSRHRA

ZNF580

126

Q9UK33
GSSAFLSHHRLKGRF

SULF2

21

Q8IWU5
ECGKTFRRSSHLIGH

ZKSCAN8

466

Q15776
LSSFRRHKRTHSGEK

ZNF14

291

P17017
RRSSGLSQHRRTHSG

ZNF358

161

Q9NW07
GKAFSRSTHLSLHQR

ZNF391

171

Q9UJN7
SRHTFRGLKSLIHLS

LGI1

131

O95970